TASHIRO Kunio 田代邦雄

Researcher Number	90002154
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2003 – 2004: 北海道医療大学, 心理科学部, 教授 2002: 北海道大学, 大学院・医学研究科, 教授 2000: Hokkaido Univ., Grad.School of Med., Professor, 大学院・医学研究科, 教授 1994 – 1999: 北海道大学, 医学部, 教授 1993 – 1994: HOKKAIDO UNIVERSITY HOSPITAL PROFESSOR, 医学部・附属病院, 教授 … More 1989 – 1992: 北海道大学, 医学部附属病院, 教授 1991: 北海道大学, 医学部, 教授 1988: 北海道大学, 医学部付属病院, 教授 Less
Review Section/Research Field	Principal Investigator Neurology Except Principal Investigator Neurology / Experimental pathology / 公衆衛生学
Keywords	Principal Investigator 多発性硬化症 / HLA / multiple sclerosis / Macrophage Inflammatory Protein (MIP) / RANTES / Proteolipid Protein / 脱髄 / SCA1 / SCA2 / SCA6 … More / 遺伝子 / Myoglobin / CA-III / human leukocyte antigen / attack-related severity / 急性横断性脊髄症 / 神経疫学 / 神経症候学 / 磁気共鳴画像 / オリゴクローナルバンド / 抗カルジオリピン抗体 / オリゴクロ-ナルバンド / 末梢神経 / acute transverse myelopathy / neuroepidemiology / neurosymptomatology / magnetic resonance imaging / oligoclonal band / anticardiolipin antibody / T細胞受容体 / βケモカイン / MIP-1α / MIP-1β / Macrophage inflammatory protein(MIP) / Proteolipid protein / Human leukocyte antigen / T cell / T cell subset / Chemokines / 接着因子 / Multiple Sclerosis / T Cell Receptor / beta -Chemokine / MIP-1 alpha / MIP-1 beta / 脊髄小脳変性症 / ジョセフ病 / CAGリピート / 遺伝子異常 / 遺伝子座 / triplet repeat病 / Spinocerebellar ataxia / Machado-Joseph disease / CAG repeat / Gene mutation / Gene locus / 神経筋疾患 / 筋酵素 / Carbonid anhydrase III / モノクローナル抗体 / 心筋梗塞 / 炭酸脱水水素酵素アイソザイムIII型 / 心筋障害 / Carbonid anhydrase / 炭酸脱水水素アイソザイム1型 / モノクローナク抗体 / ELISA / 測定方法 / 筋疾患マーカー / Garbonic anhydrase III / NEUROMUSCULAR DISEASES / MUSCLE ENZYME / CARBONIC ANHYDRASE-III / MONOCLONALANTIBODY / MYOCARDIAL INFARCTION / MYOGLOBIN / 疫学調査 / 有病率 / 疾患感受性遺伝子 / 多発生硬化症 / 遺伝子多型 / TRAIL / CTLA-4 / 視神経脊髄型 / osteopontin / ケモカイン / 髄液 / サイトカイン / MBP反応性T細胞 / 免疫 / 中枢神経 / epidemiological research / prevalence / susceptibility gene … More Except Principal Investigator 危険要因 / ライフスタイル / パーキンソン病 / 筋萎縮性側索硬化症 / 運動ニューロン疾患 / 疫学 / 遺伝子 / 脊髄小脳変性症 / spinocerebellar ataxia / glycation / oxidative stress / ALS / motor neuron / 分子生物学 / 時間分解顕微蛍光法 / ピコ秒パルスレ-ザ- / ヘキサゴナル相 / ジアシルグリセロ-ル / リポソ-ム / 蛍光寿命 / パ-キンソン病 / ケ-ス・コントロ-ル研究 / ケース・コントロール研究 / 老年痴呆 / ケース・コントロール法 / 素因遺伝子 / 環境・遺伝交互作用 / 遺伝的素因 / 遺伝子環境相関 / 神経変性疾患 / 発生率 / 趨勢変動 / ゴンペルツ分析 / 競合死因 / 遺伝子性脊髄小脳変性症 / 連鎖解析 / CAG反復配列 / 創始者効果 / 診断基準 / 電離放射線 / 原爆実験 / 神経筋症患 / 遺伝子変異 / 遺伝子治療 / ウイルスベクター / 神経筋疾患 / 第17染色体 / cDNA / 反復経頭蓋磁気刺激 / 中枢神経疾患 / うつ症状 / 8の字コイル / 大うつ病 / 前前頭野 / Choline acetyltransferase / 外的因子 / ポリオウイルス / 水銀 / ChAT / MOTOR NEURON DISEASE / AMYOTROPHIC LATERAL SCLEROSIS / CHOLINE ACETYLTRANSFERASE / EXTERNAL FACTORS / POLIO VIRUS / MERCURY / 痙性対麻痺 / 遺伝子異常 / 遺伝子座 / spastic paraplegia / gene mutation / gene locus / advanced glycation end products(AGE) / AGE / advanced glycation end products (AGES) / 発症機序 / 神経難病 / 多系統萎縮症 / spinocerebellar degeneration / molecular mechanism / neurodegenerative disorder / 最終糖化産物 / 脊髄運動ニューロン / カルボキシメチルリジン / 運動ニューロン / ユビキチン・プロテアソーム系 / 脊髄器官培養 / Amyotrophic lateral sclerosis / Advanced glycation end product / Spinal motor neuron / Carboxymethyl lysine / 脳卒中登録 / 血管性痴呆 / 予防 / 地域保健 / 高血圧 / 老人 / 脳卒中登録予防 / 地域医療ケア / コホ-ト研究 / 画像診断 / コホート研究 / Stroke Registry / Vascular Dementias / Epidemiology / Risk Factor / Prevention / Regional Health Care / Hypertention / Senile Less

Investigation of clinical and immunological heterogeneity of multiple sclerosis, and its moleculogenetical backgroundPrincipal Investigator
- Principal Investigator
  
  TASHIRO Kunio
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Health Sciences University of Hokkaido
  Hokkaido University
Causative gene mutation and molecular mechanism in spinooerebellar degeneration
- Principal Investigator
  
  SASAKI Hidenao
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  HOKKAIDO UNIVERSITY
The Association of AGEs (Advanced Glycation End product) and oxoaldehydes with spinal motor neuronal death
- Principal Investigator
  
  KIKUCHI Seiji
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  HOKKAIDO UNIVERSITY
反復経頭蓋磁気刺激法の臨床応用への安全性の検討
- Principal Investigator
  
  眞野行生
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Hokkaido University
Glycation and AGEs in motor neurons - synergism with oxidative stress -
- Principal Investigator
  
  KIKUCHI Seiji
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  HOKKAIDO UNIVERSITY
神経・筋症患の遺伝子治療に関する基礎的研究
- Principal Investigator
  
  MORIWAKA Fumio
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Hokkaido University
Molecular genetic studies of dominantly inherited spastic paraplegia
- Principal Investigator
  
  SASAKI Hidenao
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Neurology
- Research Institution
  Hokkaido University
遺伝子・環境交互作用の分析によるパーキンソン病の易羅病性の解明
- Principal Investigator
  
  近藤喜代太郎
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
THE DIAGNOSTIC STRATEGIES AND THE CLINICAL APPLICATION OF CARBONIC ANHYDRASE-III IN THE NEUROMUSCULAR DISEASESPrincipal Investigator
- Principal Investigator
  
  TASHIRO Kunio
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  HOKKAIDO UNIVERSITY
遺伝子・環境交互作用の分析によるパーキンソン病の易罹病性の解明
- Principal Investigator
  
  近藤喜代太郎
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
遺伝性脊髄小脳変性症における三塩基反復配列の探索
- Principal Investigator
  
  WAKISAKA Akemi
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Hokkaido University
MOLECULAR GENETIC STUDY OF HEREDITARY SPINOCEREBELLAR ATAXIAPrincipal Investigator
- Principal Investigator
  
  TASHIRO Kunio
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  HOKKAIDO UNIVERSITY
遺伝子・環境交互作用の分析によるパーキンソン病の易罹病性の解明
- Principal Investigator
  
  近藤喜代太郎
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
パーキンソン病の危険要因に関する分析疫学的研究
- Principal Investigator
  
  近藤喜代太郎
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
Research in the pathogenesis of multiple sclerosis. Analysis of characteristics of T cell receptor.Principal Investigator
- Principal Investigator
  
  TASHIRO Kumio
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  HOKKAIDO UNIVERSITY
パーキンソン病の危険要因に関する分析疫学的研究
- Principal Investigator
  
  近藤喜代太郎
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
RESEARCH IN THE PATHOGENESIS OF MOTOR NEURON DISEASES.ANALYSIS OF CHOLINE ACETYLTRANSFERASE GENE EXPRESSION IN SPINAL MOTOR NEURON.
- Principal Investigator
  
  MORIWAKA Fumio
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  HOKKAIDO UNIVERSITY
時間分解顕微蛍光法によるトランスミッタ-放出機構の解析
- Principal Investigator
  
  石俊輝雄
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
パ-キンソン病の危険要因に関する分析疫学的研究
- Principal Investigator
  
  KONDO Kiyotaro
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
Symptomatological and epidemiological studies on multiple sclerosis in HokkaidoPrincipal Investigator
- Principal Investigator
  
  TASHIRO Kunio
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Hokkaido University
Prevention of Vascular Dementias with Stroke Registry
- Principal Investigator
  
  KONDO Kiyotaro
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  公衆衛生学
- Research Institution
  Hokkaido University

All 2005 2004 2003 2002

All Journal Article Book

[Book] AGEs研究の最前線2004
- Author(s)
  田代淳
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] CSF pleocytosis and expansion of spinal lesions in Japanese MS : A special reference to the new diagnostic criteria2005
- Author(s)
  Fukazawa T, Kikuchi S, Tashiro K, et al.
- Journal Title
  
  Journal of Neurology 252(Published online March 6,1-)
- Data Source
  KAKENHI-PROJECT-14370201
[Journal Article] Interferon beta-1b is effective in Japanese RRMS patients, A randomized, multicenter study.2005
- Author(s)
  Saida T, Tashiro K., et al.
- Journal Title
  
  Neurology 64
  
  Pages: 621-629
- Data Source
  KAKENHI-PROJECT-14370201
[Journal Article] Ibudilast, a non-selective phosphodiesterase inhibitor, regulates Th1/Th2 balance and NKT cell subset in MS2004
- Author(s)
  Feng J, Fukaura H, Kikuchi S, Tashiro k, et al.
- Journal Title
  
  Multiple Sclerosis 10
  
  Pages: 494-498
- Data Source
  KAKENHI-PROJECT-14370201
[Journal Article] Attack-related severity : Akey factor in understanding the spectrum of idiopathic inflammatory demyelinating disorders2004
- Author(s)
  Fukazawa T, Kikuchi S, Niino M, Tashiro K., et al.
- Journal Title
  
  Journal of the Neurological Sciences 225
  
  Pages: 71-78
- Data Source
  KAKENHI-PROJECT-14370201
[Journal Article] 日本における多発性硬化症疫学調査の意義2004
- Author(s)
  田代邦雄
- Journal Title
  
  神経内科 61
  
  Pages: 411-414
- Data Source
  KAKENHI-PROJECT-14370201
[Journal Article] Platelet-activating factor acethylhydrolase gene polymorphism and its activity in Japanese patients with multiple sclerosis2004
- Author(s)
  Osoegawa M, Niino M, Kikuchi S, Tashiro K, et al.
- Journal Title
  
  Journal of Neuroimmunology 150
  
  Pages: 150-156
- Data Source
  KAKENHI-PROJECT-14370201
[Journal Article] Brefeldin A-induced neurotoxicity in cultured.spinal cord neurons.2003
- Author(s)
  Kikuchi S, Shinpo K, Tsuji S, Yabe I, Niino M, Tashiro K
- Journal Title
  
  J Neurosci Res 71
  
  Pages: 591-599
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] Glycation -a sweet tempter for neuronal death2003
- Author(s)
  Kikuchi S, Shinpo K, Takeuchi M, Yamagishi S, Makita Z, Sasaki N, Tashiro K
- Journal Title
  
  Brain Research Reviews 41
  
  Pages: 306-323
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] Effect of proteasome inhibitor on cultured mesencephalic dopaminergic neurons2003
- Author(s)
  Kikkuchi S, Shinpo K, Tsuji S, Masayoshi T, Yamagishi S, Makita Z, Niino M, Yabe I, Tashiro K
- Journal Title
  
  Brain Res 964
  
  Pages: 228-236
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] Prostaglandin E1 protects cultured spinal neurons against the effects of nitiric oxide toxicity2002
- Author(s)
  Kikuchi S, Shinpo K, Niino M, Tsuji S, Iwabuchi K, Onoe K, Tashiro K
- Journal Title
  
  Neuropharmachology 42
  
  Pages: 714-723
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] Detection of N^E-(carboxymethyl) lysine (CML) and non-CML advanced glycation end-products in the anterior horn of amyotrophic lateral sclerosis spinal cord2002
- Author(s)
  Kikuchi S, Shinpo K, Ogata A, Tsuji S, Takeuchi M, Makita Z, Tashiro K
- Journal Title
  
  ALS and other motor neuron disorders 3
  
  Pages: 63-66
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] Progress in the field of neurology in the last 100 years : Triplet repeat disease.2002
- Author(s)
  Tashiro K
- Journal Title
  
  Nippon Natka Gakkai Zasshi 91
  
  Pages: 2263-2267
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370202
[Journal Article] Effect of Geranylgeranylaceton on Cellular Damage Induced by Proteasome Inhibition in Culutured Spinal Neurons2002
- Author(s)
  Kikuchi S, Shinpo K, Takeuchi M, Tsuji S, Yabe I, Niino M, Tashiro K
- Journal Title
  
  Journal of Neuroscience Research 69
  
  Pages: 373-381
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] 新しい遺伝子異常・トリプレットリピート病2002
- Author(s)
  田代邦雄
- Journal Title
  
  日本内科学会雑誌内科-100年のあゆみ(神経) 特集
  
  Pages: 2263-2267
- NAID
  10010929451
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370202

1. MORIWAKA Fumio (30142722)

# of Collaborated Projects: 11 results

# of Collaborated Products: 0 results
2. KONDO Kiyotaro (80018366)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
3. 志渡晃一 (20206098)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
4. KIKUCHI Seiji (10271660)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
5. WAKISAKA Akemi (90113646)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. SASAKI Hidenao (80281806)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. 新野峰久 (80180561)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 羽田明 (00244541)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. YABE Ichiro (60372273)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TANAKA Heizou (70047215)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NAGAI Masashi (90124403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. THOGI Hideo (90155490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 石俊輝雄 (60001872)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 荒磯恒久 (30151145)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 西平順 (30189302)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 高桑雄一 (40113740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 池田仁 (20232192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 吉木敬 (60220612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 眞野行生 (20145882)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 辻貞俊 (30117171)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 中馬孝容 (70281805)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 松浦亨 (90271676)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. HIBI Nozomi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. TSUKADA Hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. SUZUKI Kazuo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 杉村巌

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TASHIRO Kunio 田代 邦雄

Research Projects

Research Products

Co-Researchers

Investigation of clinical and immunological heterogeneity of multiple sclerosis, and its moleculogenetical backgroundPrincipal Investigator

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THE DIAGNOSTIC STRATEGIES AND THE CLINICAL APPLICATION OF CARBONIC ANHYDRASE-III IN THE NEUROMUSCULAR DISEASESPrincipal Investigator

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MOLECULAR GENETIC STUDY OF HEREDITARY SPINOCEREBELLAR ATAXIAPrincipal Investigator

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Research in the pathogenesis of multiple sclerosis. Analysis of characteristics of T cell receptor.Principal Investigator

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Principal Investigator

TASHIRO Kunio 田代邦雄