Saito Yoshiro 斎藤芳郎

… Alternative Names

Researcher Number	70357060
Other IDs	https://orcid.org/0000-0002-0559-5889
External Links
Affiliation (Current)	2022: 東北大学, 薬学研究科, 教授
Affiliation (based on the past Project Information) *help	2021: 東北大学, 薬学研究科(研究院), 教授 2017 – 2021: 東北大学, 薬学研究科, 教授 2017: 同志社大学, 生命医科学部, 教授 2013 – 2016: 同志社大学, 生命医科学部, 准教授 2009: 独立行政法人産業技術総合研究所, ヒューマンストレスシグナル研究センター, 研究員 2007: National Institute of Advanced Industrial Science and Technology, ヒューマンストレスシグナル研究センター, 研究員 2004 – 2007: 独立行政法人産業技術総合研究所, ヒューマンストレスシグナル研究センター, 研究員
Review Section/Research Field	Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields / Biological pharmacy / Food science / Medical pharmacy / Complex systems / Transformative Research Areas, Section (III) Except Principal Investigator Eating habits, studies on eating habits / Eating habits / Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator セレン / 酸化ストレス / 膵β細胞 / セレノプロテイン / 糖尿病 / セレノプロテインP / インスリン分泌 / パーキンソン病 / 活性酸素種 / アポトーシス … More Except Principal Investigator 酸化ストレス / ビタミンE / コレステロール / 機能性食品 / 酸化ストレスマーカー / ヒドロキシリノール酸 / ヒドロキシコレステロール / タンパク質酸化修飾 / 酸化DJ-1 / コエンザイムQ / 酸化修飾DJ-1 / トコフェロール / 脂質酸化物 / トコフェリルキノン / グルタチオン / リノール酸 / 抗酸化物質 / オキシステロール / 神経細胞死 / アルツハイマー病 / 小胞体ストレス / 脂肪滴 / 24S-ヒドロキシコレステロール / ACAT1 / 膜破綻 / CaMKII / phospho-CaMKII / 膜の流動性 / 神経変性疾患 / 食品 / 脂質 / 脳神経疾患 / 生体分子 / シグナル伝達 / 疲労 / 微量元素 / ミネラル / 亜鉛 / メンタルヘルス / フリッカー / 学生 / 食生活 / メンタル / 栄養素 Less

超硫黄分子とセレンのクロストークによるシグナル伝達制御Principal Investigator
- Principal Investigator
  
  斎藤芳郎
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Tohoku University
Creation of "disease metallomics" to understand the relationship between fluctuations of heavy metals/trace elements and diseasesPrincipal Investigator
- Principal Investigator
  
  斎藤芳郎
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Tohoku University
Regulatory mechanism of selenoprotein P expression and its deterioration mechanism of glucose metabolismPrincipal Investigator
- Principal Investigator
  
  斎藤芳郎
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Tohoku University
Elucidation of a dynamics control mechanism of seleniumPrincipal Investigator
- Principal Investigator
  
  斎藤芳郎
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tohoku University
Omics analysis for the establishment of "reductive stress," a biological disorder caused by excessive antioxidant and reductive environmentPrincipal Investigator
- Principal Investigator
  
  Saito Yoshiro
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Tohoku University
Fatigue assessment and analysis of trace element deficiency and eating habits survey for prevention of mental health disorder of university students
- Principal Investigator
  
  亀尾聡美
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Koshien University
Molecular mechanisms of disorder of pancreatic beta cells induced by excess selenoprotein PPrincipal Investigator
- Principal Investigator
  
  Saito Yoshiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Food science
- Research Institution
  Tohoku University
Mechanism of inhibition of oxysterol-induced Alzheimer's disease by vitamin E
- Principal Investigator
  
  Noguchi Noriko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  Doshisha University
Selenium-transport mechanism of selenoprotein PPrincipal Investigator
- Principal Investigator
  
  Saito Yoshiro
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Food science
- Research Institution
  Doshisha University
Development of diagnosis and treatment of Parkinson disease at early stage using novel biomarker oxidized DJ-1Principal Investigator
- Principal Investigator
  
  Yoshiro Saito
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Doshisha University
The study on functional food using oxidative stress marker, hydroxyoctadecadienoic acid and 7-hydroxycholesterol
- Principal Investigator
  
  YOSHIDA Yasukazu
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  National Institute of Advanced Industrial Science and Technology
培養神経細胞および幼若ラット脳を用いたドーパミン神経障害メカニズムの探究Principal Investigator
- Principal Investigator
  
  斎藤芳郎
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Advanced Industrial Science and Technology
酸化血清中に存在する細胞傷害因子の探索-新規酸化ストレスマーカーの同定を目指してPrincipal Investigator
- Principal Investigator
  
  斎藤芳郎
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Advanced Industrial Science and Technology

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2009 2008 2007 2006

All Journal Article Presentation Book Patent

[Book] Vitamin E: Chemistry and Nutritional Benefits2019
- Author(s)
  Yoshiro Saito and Yasukazu Yoshida
- Total Pages
  269
- Publisher
  Royal Society of Chemistry
- Data Source
  KAKENHI-PROJECT-16K00882
[Book] レドックス疾患学　セレノプロテインPによるレドックス制御と2型糖尿病2018
- Author(s)
  斎藤芳郎、野口範子、御簾博文、篁俊成
- Total Pages
  6
- Publisher
  羊土社
- ISBN
  9784758103695
- Data Source
  KAKENHI-PROJECT-17H03821
[Book] Vitamin E: Chemistry and Nutritional Benefits.2018
- Author(s)
  Yoshiro Saito and Yasukazu Yoshida
- Total Pages
  12
- Publisher
  Royal Society of Chemistry
- ISBN
  9781788016216
- Data Source
  KAKENHI-PROJECT-17H03821
[Book] レドックス疾患学2018
- Author(s)
  斎藤芳郎、野口範子、御簾博文、篁俊成
- Total Pages
  7
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-16K00882
[Book] 別冊「医学のあゆみ」レドックスUPDATE ストレス制御の臨床医学・健康科学2015
- Author(s)
  斎藤芳郎、野口範子
- Total Pages
  360
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-25670084
[Book] パーキンソン病と酸化ストレス　酸化ストレスの医学、第2版2014
- Author(s)
  斎藤芳郎、野口範子
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-25670084
[Book] ストレスの科学と健康2008
- Author(s)
  斎藤芳郎
- Total Pages
  8
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-18790081
[Book] 蛋白質の翻訳後修飾と疾患プロテオミクス2006
- Author(s)
  斎藤芳郎, 絹見朋也, 二木鋭雄
- Total Pages
  6
- Publisher
  抗酸化蛋白質DJ-1の酸化修飾による機能制御
- Data Source
  KAKENHI-PROJECT-18790081
[Journal Article] Lipid peroxidation products as a mediator of toxicity and adaptive response-The regulatory role of selenoprotein and vitamin E2021
- Author(s)
  Saito Yoshiro
- Journal Title
  
  Archives of Biochemistry and Biophysics
  
  Volume: 703 Pages: 108840-108840
- DOI
  10.1016/j.abb.2021.108840
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-20H05491
[Journal Article] Point mutation bias in SARS-CoV-2 variants results in increased ability to stimulate inflammatory responses2020
- Author(s)
  Kosuge Masato、Furusawa-Nishii Emi、Ito Koyu、Saito Yoshiro、Ogasawara Kouetsu
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Pages: 17766-17766
- DOI
  10.1038/s41598-020-74843-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K24138, KAKENHI-PLANNED-16H06497, KAKENHI-PUBLICLY-20H05491
[Journal Article] Circulating Concentrations of Insulin Resistance-Associated Hepatokines, Selenoprotein P and Leukocyte Cell-Derived Chemotaxin 2, during an Oral Glucose Tolerance Test in Humans2019
- Author(s)
  Mohri K, Misu H, Takayama H, Ishii KA, Kikuchi A, Lan F, Enyama Y, Takeshita Y, Saito Y, Kaneko S,Takamura T.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 42 Issue: 3 Pages: 373-378
- DOI
  10.1248/bpb.b18-00549
- NAID
  130007607371
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09739, KAKENHI-PROJECT-16K09740, KAKENHI-PROJECT-18K08507, KAKENHI-PROJECT-18K19560, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-19K08975, KAKENHI-PROJECT-17H04199, KAKENHI-PROJECT-17K09822, KAKENHI-PROJECT-17H03821
[Journal Article] Response by Kikuchi et al Regarding Article, “Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension: A Possible Novel Therapeutic Target”2019
- Author(s)
  Kikuchi N, Satoh K, Saito Y, Shimokawa H.
- Journal Title
  
  Circulation
  
  Volume: 139 Pages: 724-725
- DOI
  10.1161/circulationaha.118.038479
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08094, KAKENHI-PROJECT-19H03647, KAKENHI-PROJECT-17H03821
[Journal Article] Tocopherol suppresses 24(S)-hydroxycholesterol-induced cell death via inhibition of CaMKII phosphorylation2018
- Author(s)
  Kimura Yuki、Asa Minori、Urano Yasuomi、Saito Yoshiro、Nishikawa Kiyotaka、Noguchi Noriko
- Journal Title
  
  Biochimie
  
  Volume: 153 Pages: 203-209
- DOI
  10.1016/j.biochi.2018.07.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08254, KAKENHI-PROJECT-17H03821
[Journal Article] Hydrogen Peroxide-Reducing Factor Released by PC12D Cells Increases Cell Tolerance against Oxidative Stress2018
- Author(s)
  Asami Muraishi, Emi Haneta, Yoshiro Saito, Yutaka Hitomi, Mamoru Sano, Noriko Noguchi
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 41 Issue: 5 Pages: 777-785
- DOI
  10.1248/bpb.b18-00016
- NAID
  130006730719
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K14226, KAKENHI-PUBLICLY-18H04274, KAKENHI-PROJECT-16H04124, KAKENHI-PROJECT-17H03821
[Journal Article] Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population2018
- Author(s)
  Oo SM, Misu H, Saito Y, Tanaka M, Kato S, Kita Y, Takayama H, Takeshita Y, Kanamori T, Nagano T, Nakagen M, Urabe T, Matsuyama N, Kaneko S, Takamura T.
- Journal Title
  
  Sci Rep
  
  Volume: 8 Pages: 16727-16727
- DOI
  10.1038/s41598-018-35067-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09739, KAKENHI-PROJECT-16K09740, KAKENHI-PROJECT-18K19560, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-17H04199, KAKENHI-PROJECT-17H03821
[Journal Article] Pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy.2018
- Author(s)
  Shimasaki K, Watanabe-Takahashi M, Umeda M, Funamoto S, Saito Y, Noguchi N, Kumagai K, Hanada K, Tsukahara F, Maru Y, Shibata N, Naito M, Nishikawa K.
- Journal Title
  
  Genes Cells
  
  Volume: 23 Pages: 22-34
- DOI
  10.1111/gtc.12544
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07044, KAKENHI-PLANNED-15H05930, KAKENHI-PROJECT-17H03805, KAKENHI-PROJECT-15K08480, KAKENHI-ORGANIZER-17H06413, KAKENHI-PROJECT-17H03821
[Journal Article] PARK7 modulates autophagic proteolysis through binding to the N-terminally arginylated form of the molecular chaperone HSPA52018
- Author(s)
  Lee Dae-Hee、Kim Daeho、Kim Sung Tae、Jeong Soyeon、Kim Jung Lim、Shim Sang Mi、Heo Ah Jung、Song Xinxin、Guo Zong Sheng、Bartlett David L.、Oh Sang Cheul、Lee Junho、Saito Yoshiro、Kim Bo Yeon、Kwon Yong Tae、Lee Yong J.
- Journal Title
  
  Autophagy
  
  Volume: 14 Pages: 1870-1885
- DOI
  10.1080/15548627.2018.1491212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03821
[Journal Article] Tocopherol suppresses 24(S)-hydroxycholesterol-induced cell death via inhibition of CaMKII phosphorylation.2018
- Author(s)
  Yuki Kimura, Minori Asa, Yasuomi Urano, Yoshiro Saito, Kiyotaka Nishikawa, Noriko Noguchi
- Journal Title
  
  Biochimie
  
  Volume: 153 Pages: 203-209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K00882
[Journal Article] Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension2018
- Author(s)
  Kikuchi N, Satoh K, Kurosawa R, Yaoita N, Elias-Al-Mamun M, Siddique MAH, Omura J, Satoh T, Nogi M, Sunamura S, Miyata S, Saito Y, Hoshikawa Y, Okada Y, Shimokawa H.
- Journal Title
  
  Circulation
  
  Volume: 138 Pages: 600-623
- DOI
  10.1161/circulationaha.117.033113
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08094, KAKENHI-PROJECT-16K00039, KAKENHI-PROJECT-17K15982, KAKENHI-PROJECT-17H03821
[Journal Article] Diagnosis of Parkinson’s disease and the level of oxidized DJ-1 protein2018
- Author(s)
  Yamagishi Y, Saigoh K, Saito Y, Ogawa I, Mitsui Y, Hamada Y, Samukawa M, Suzuki H, Kuwahara M, Hirano M, Noguchi N, Kusunoki S.
- Journal Title
  
  Neuroscience Research
  
  Volume: なし Pages: 58-62
- DOI
  10.1016/j.neures.2017.06.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09705, KAKENHI-PROJECT-17H03821
[Journal Article] Distribution of oxidized DJ-1 in Parkinson’s disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin2018
- Author(s)
  Mita Yuichiro、Kataoka Yuto、Saito Yoshiro、Kashi Takuma、Hayashi Kojiro、Iwasaki Asa、Imanishi Takanori、Miyasaka Tomohiro、Noguchi Noriko
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Pages: 12056-12056
- DOI
  10.1038/s41598-018-30561-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-16K18707, KAKENHI-PROJECT-17H03821
[Journal Article] Comparison of Human Selenoprotein P Determinants in Serum between Our Original Methods and Commercially Available Kits2018
- Author(s)
  Saito Yoshiro、Misu Hirofumi、Takayama Hiroaki、Takashima Shin-ichiro、Usui Soichiro、Takamura Masayuki、Kaneko Shuichi、Takamura Toshinari、Noguchi Noriko
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 41 Issue: 5 Pages: 828-832
- DOI
  10.1248/bpb.b18-00046
- NAID
  130006730702
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19560, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-17H04199, KAKENHI-PROJECT-16K09425, KAKENHI-PROJECT-17H03821
[Journal Article] 6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based unconventional secretory pathway2018
- Author(s)
  Urano Yasuomi、Mori Chinatsu、Fuji Ayano、Konno Keito、Yamamoto Takayuki、Yashirogi Shohei、Ando Mayu、Saito Yoshiro、Noguchi Noriko
- Journal Title
  
  Autophagy
  
  Volume: 14 Pages: 1943-1958
- DOI
  10.1080/15548627.2018.1493043
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08254, KAKENHI-PROJECT-17H03821
[Journal Article] Selenoprotein P-neutralizing antibody improves insulin secretion and glucose intolerance in mouse models for type 2 diabetes2017
- Author(s)
  Mita Yuichiro、Nakayama Kaho、Inari Shogo、Nishito Yukina、Yoshioka Yuya、Sakai Naoko、Sotani Kanade、Nagamura Takahiro、Kuzuhara Yuki、Inagaki Kumi、Iwasaki Miki、Misu Hirofumi、Ikegawa Masaya、Takamura Toshinari、Noguchi Noriko、Saito Yoshiro
- Journal Title
  
  Nature Communications
  
  Volume: 8 Pages: 1658-1658
- DOI
  10.1038/s41467-017-01863-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09740, KAKENHI-PROJECT-16K18707, KAKENHI-PROJECT-17H04199, KAKENHI-PROJECT-17H03821
[Journal Article] Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of ROS and AMPK in muscle2017
- Author(s)
  H Misu, H Takayama, Y Saito, Y Mita, A Kikuchi, K Ishii, K Chikamoto, T Kanamori, N Tajima, F Lan, Y Takeshita, M Honda, M Tanaka, S Kato, N Matsuyama, Y Yoshioka, Iwayama K, Tokuyama K, Akazawa N, Maeda S, Takekoshi K, Matsugo S, Noguchi N, S Kaneko, T Takamura.
- Journal Title
  
  Nat Med
  
  Volume: 23 Pages: 508-516
- DOI
  10.1038/nm.4295
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26461328, KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-16K15426, KAKENHI-PROJECT-16K09739, KAKENHI-PROJECT-16K09740, KAKENHI-PROJECT-25292078, KAKENHI-PROJECT-17H04199
[Journal Article] Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47phox2017
- Author(s)
  Bharatwaj Sowrirajan, Yoshiro Saito, Deepak Poudyal, Qian Chen, Hongyan Sui, Suk See DeRavin, Hiromi Imamichi, Toyotaka Sato, Douglas B. Kuhns, Noriko Noguchi, Harry L. Malech, H. Clifford Lane and Tomozumi Imamichi
- Journal Title
  
  Sci Rep
  
  Volume: 7 Pages: 43441-43441
- DOI
  10.1038/srep43441
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25292078, KAKENHI-PROJECT-17K15688
[Journal Article] Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes2017
- Author(s)
  Tajima-Shirasaki N, Ishii KA, Takayama H, Shirasaki T, Iwama H, Chikamoto K, Saito Y, Iwasaki Y, Teraguchi A, Lan F, Kikuchi A, Takeshita Y, Murao K, Matsugo S, Kaneko S, Misu H, Takamura T.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Pages: 10791-10800
- DOI
  10.1074/jbc.m116.747006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09739, KAKENHI-PROJECT-16K09740, KAKENHI-PROJECT-16K21058, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-17H04199, KAKENHI-PROJECT-17H03821
[Journal Article] Effect of vitamin E on 24(S)-hydroxycholesterol-induced necroptosis-like cell death and apoptosis.2017
- Author(s)
  Takaya Nakazawa, Yuta Miyanoki, Yasuomi Urano, Madoka Uehara, Yoshiro Saito, Noriko Noguchi
- Journal Title
  
  J. Steroid Biochem. Mol. Biol.
  
  Volume: 169 Pages: 69-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K00882
[Journal Article] Development of a sol particle homogeneous immunoassay for measuring full-length selenoprotein P in human serum.2016
- Author(s)
  M. Tanaka, Y. Saito, H. Misu, S. Kato, Y. Kita, Y. Takeshita, T. Kanamori, T. Nagano, M. Nakagen, T. Urabe, T. Takamura, S. Kaneko, K. Takahashi and N. Matsuyama.
- Journal Title
  
  Journal of Clinical Laboratory Analysis
  
  Volume: 30 Pages: 114-122
- DOI
  10.1002/jcla.21824
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461334, KAKENHI-PROJECT-25292078, KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-16K09740
[Journal Article] Oxidized Lipoprotein as a Major Vessel Cell Proliferator in Oxidized Human Serum.2016
- Author(s)
  Yoshiro Saito, and Noriko Noguchi
- Journal Title
  
  PLoS ONE
  
  Volume: 11
- DOI
  10.1371/journal.pone.0160530
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25292078
[Journal Article] セレンの生物学―セレノプロテインの機能と疾患2016
- Author(s)
  斎藤芳郎
- Journal Title
  
  細胞工学
  
  Volume: 35 Pages: 240-246
- NAID
  40020761203
- Data Source
  KAKENHI-PROJECT-25292078
[Journal Article] Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson’s disease patients.2016
- Author(s)
  Y. Saito, Y. Akazawa-Ogawa, A. Matsumura, K. Saigoh, S. Itoh, K. Sutou, M. Kobayashi, Y. Mita, M. Shichiri, S. Hisahara, Y. Hara, H. Fujimura, H. Takamatsu, Y. Hagihara, Y. Yoshida, T. Hamakubo, S. Kusunoki, S. Shimohama, N. Noguchi
- Journal Title
  
  Scientific Reports
  
  Volume: 29 Pages: 30793-30793
- DOI
  10.1038/srep30793
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24108007, KAKENHI-PROJECT-16K18707, KAKENHI-PROJECT-25292078
[Journal Article] New aspects of 24(S)-hydroxycholesterol in modulating neuronal cell death.2015
- Author(s)
  Noriko Noguchi, Yasuomi Urano, Wakako Takabe, Yoshiro Saito
- Journal Title
  
  Free Radical Biology & Medicine
  
  Volume: 87 Pages: 366-372
- DOI
  10.1016/j.freeradbiomed.2015.06.036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670084, KAKENHI-PROJECT-26850089
[Journal Article] 24(S)-Hydroxycholesterol induces RIPK1-dependent but MLKL-independent cell death in the absence of caspase-8.2015
- Author(s)
  Vo DK, Urano Y, Takabe W, Saito Y, Noguchi N.
- Journal Title
  
  Steloids
  
  Volume: 印刷中 Pages: 230-237
- DOI
  10.1016/j.steroids.2015.02.007
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25830041, KAKENHI-PROJECT-25670084, KAKENHI-PROJECT-26850089
[Journal Article] Enhancement of lipid peroxidation and its amelioration by vitamin E in a subject with mutations in the SBP2 gene.2015
- Author(s)
  Shioji Ishiwatari, Minako Takahashi, Chie Yasuda, Maho Nakagawa, Tatsuya Kon, Yoshiro Saito, Noriko Noguchi, and Shoko Matsukuma
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 307 Pages: 2172-2182
- DOI
  10.1007/s00403-015-1605-8
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25670084, KAKENHI-PROJECT-25292078
[Journal Article] 7-Hydroxycholestrol as a possible biomarker of cellular lipid peroxidation: Difference between cellular and plasma lipid peroxidation.2014
- Author(s)
  Yoshiro Saito and Noriko Noguchi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25292078
[Journal Article] LECT2 Functions as a Hepatokine That Links Obesity to Skeletal Muscle Insulin Resistance.2014
- Author(s)
  Fei Lan, H Misu, K Chikamoto, H Takayam, A Kikuchi, K Mohri, N Takata, H Hayashi, N Matsuzawa-Nagata, Y Takeshita, H Noda, Y Matsumoto, T Ota, T Nagano, M Nakagen, K Miyamoto, K Takatsuki, T Seo, K Iwayama, K Tokuyama, S Matsugo, H Tang, Y Saito, S Yamagoe, S Kaneko, T Takamura
- Journal Title
  
  Diabetes
  
  Volume: 63 Pages: 1649-1664
- DOI
  10.2337/db13-0728
- NAID
  120005440333
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J03079, KAKENHI-PROJECT-23590275, KAKENHI-PROJECT-23591301, KAKENHI-PROJECT-25282017, KAKENHI-PROJECT-25292078, KAKENHI-PROJECT-25461334, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-26670229
[Journal Article] Oxidized DJ-1 as a possible biomarker of Parkinson’s disease.2014
- Author(s)
  Yoshiro Saito
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: -
- NAID
  130004466748
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670084
[Journal Article] Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis byinducing VEGF resistance in vascular endothelial cells.2014
- Author(s)
  Ishikura K, Misu H, Kumazaki M, Takayama H, Matsuzawa-Nagata N, Tajima N, Chikamoto K, Lan F, Ando H, Ota T, Sakurai M, Takeshita Y, Kato K, Fujimura A, Miyamoto K, Saito Y, Kameo S, Okamoto Y, Takuwa Y, Takahashi K, Kidoya H, Takakura N, Kaneko S, Takamura T
- Journal Title
  
  Diabetologia.
  
  Volume: 57 Pages: 1968-1976
- DOI
  10.1007/s00125-014-3306-9
- NAID
  120005463349
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22112005, KAKENHI-PROJECT-24390051, KAKENHI-PUBLICLY-25116711, KAKENHI-PUBLICLY-25122710, KAKENHI-PROJECT-25282017, KAKENHI-PROJECT-25292078, KAKENHI-PROJECT-25461334, KAKENHI-PROJECT-25670162, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-26461329
[Journal Article] Diverse functions of 24(S)-hydroxycholesterol in the brain.2014
- Author(s)
  Noriko Noguchi, Yoshiro Saito, and Yasuomi Urano
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 446 Pages: 692-696
- DOI
  10.1016/j.bbrc.2014.02.010
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25292078, KAKENHI-PROJECT-25830041
[Journal Article] Immunostaining of oxidized DJ-1 in human and mouse brain.2014
- Author(s)
  Saito, Y., T. Miyasaka, H. Hatsuta, K. Takahashi-Niki, K. Hayashi, Y. Mita, O. Kusano-Arai, H. Iwanari, H. Ariga, T. Hamakubo, Y. Yoshida, E. Niki, S. Murayama, Y. Ihara and N. Noguchi
- Journal Title
  
  Journal of Neuropathology and Experimental Neurology
  
  Volume: 73 Pages: 714-28
- DOI
  10.1097/nen.0000000000000087
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-24108007, KAKENHI-PROJECT-24790773, KAKENHI-PROJECT-25220205, KAKENHI-PROJECT-25670084
[Journal Article] Induction of apoptosis and necroptosis by 24(S)-hydroxycholesterol is dependent on activity of acyl-CoA:cholesterol acyltransferase 12014
- Author(s)
  K Yamanaka, Y Urano, W Takebe, Y Saito, N Noguchi
- Journal Title
  
  Cell Death & Disease
  
  Volume: Vol. 5
- DOI
  10.1038/cddis.2013.524
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-12J03567, KAKENHI-PROJECT-25670084, KAKENHI-PROJECT-25830041
[Journal Article] Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death.2014
- Author(s)
  Akishi Okabe, Yasuomi Urano, Sayoko Itoh, Naoto Suda, Rina Kotani, Yuki Nishimura, Yoshiro Saito, and Noriko Noguchi
- Journal Title
  
  Redox Biology
  
  Volume: 2 Pages: 28-35
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670084
[Journal Article] The significance of oxidized DJ-1 protein (oxDJ-1) as a biomarker for Parkinson’s disease.2014
- Author(s)
  Ikuko Ogawa, Yoshiro Saito, Kazumasa Saigoh, Yoshie Hosoi, Yoshiyuki Mitsui, Noriko Noguchi, and Susumu Kusunoki
- Journal Title
  
  Brain and Nerve
  
  Volume: 66 Pages: 471-477
- NAID
  40020069623
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670084
[Journal Article] パーキンソン病におけるバイオマーカーの現状―マイケルＪフォックス財団の取り組み2013
- Author(s)
  斎藤芳郎
- Journal Title
  
  ファルマシア
  
  Volume: 49 Pages: 870-872
- NAID
  110009995817
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670084
[Journal Article] Metformin Suppresses Expression of the Selenoprotein P gene via an AMPK-FoxO3a Pathway in H4IIEC3 Hepatocytes.2013
- Author(s)
  Hiroaki Takayama, Hirofumi Misu, Hisakazu Iwama, Keita Chikamoto, Yoshiro Saito, Koji Murao, Atsushi Teraguchi, Fei Lan, Akihiro Kikuchi, Reina Saito, Natsumi Tajima, Takayoshi Shirasaki, Seiichi Matsugo, Ken-ichi Miyamoto, Shuichi Kaneko, and Toshinari Takamura
- Journal Title
  
  Journal of Biological Chemistry,
  
  Volume: 289 Pages: 335-345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25292078
[Journal Article] Characterization of cellular uptake and distribution of coenzyme Q10 and vitamin E in PC12 cells.2009
- Author(s)
  斎藤芳郎, 福原明子, 西尾敬子, 早川三恵子, 小川陽子, 坂本Hirokazu, 藤井健志, 吉田康一, 二木鋭雄
- Journal Title
  
  Journal of Nutritional Biochemistry vol.20
  
  Pages: 350-357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300256
[Journal Article] Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients2009
- Author(s)
  斎藤芳郎, 濱窪隆雄, 吉田康一, 小川陽子(以下省略10人), 二木鋭雄
- Journal Title
  
  Nuroscience Letters vol463
  
  Pages: 1-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300256
[Journal Article] Gamma-tocopheryl quinine, not alpha-tocopheryl quinine, induces adaptive response through up-regulation of cellular glutathione and cysteine anailability via activation ATF4.2008
- Author(s)
  小川陽子, 斎藤芳郎, 西尾敬子, 吉田康一, 芦田均, 二木鋭雄
- Journal Title
  
  Free Radical Resarch vol.42
  
  Pages: 674-687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300256
[Journal Article] Cytotoxic effects of various stressors on PC12 cells : Involvement of oxidative stress and effect of antioxidants2007
- Author(s)
  Rosaria Piga, Yoshiro Saito*, Yasukazu Yoshida, Etsuo Niki
- Journal Title
  
  NeuroToxicology 28
  
  Pages: 67-67
- Data Source
  KAKENHI-PROJECT-18790081
[Journal Article] Protective effects of 15-deoxy-prostaglandin J2 against glutamate-induced2007
- Author(s)
  Y Saito, K Nishio, et. al.
- Journal Title
  
  J Neurochemistry 102
  
  Pages: 1625-1634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790081
[Journal Article] Levels of Lipid Peroxidation in Human Plasma and Erythrocytes2007
- Author(s)
  Y Yoshida, Y Saito, et. al.
- Journal Title
  
  Lipids 42
  
  Pages: 439-449
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790081
[Journal Article] Cholesterol is more susceptible to oxidation than linolates in cultured cells under oxidative stress induced by selenium deficiebcy and free radicals.2007
- Author(s)
  斎藤芳郎, 吉田康一, 二木鋭雄
- Journal Title
  
  FEBS Letters vol.581
  
  Pages: 4349-4354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300256
[Journal Article] Cholesterol is more susceptible to oxidation than linoleates in cultured cells under oxidativestress induced by selenium deficiency and free radicals2007
- Author(s)
  Saito Y, Yoshida Y, and Niki E
- Journal Title
  
  FEBS Lett 581
  
  Pages: 4349-4354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300256
[Journal Article] Molecular mechanisms of 6-hydroxydopamine-induced cytotoxicity in PC12 cells- INVOLVEMENT OF HYDROGEN PEROXIDE-DEPENDENT AND -INDEPENDENT ACTION2007
- Author(s)
  Yoshiro Saito*, Keiko Nishio, Yoko Ogawa, Tomoya Kinumi, Yasukazu Yoshida, Yoshinori Masuo, Etsuo Niki
- Journal Title
  
  Free Radical Biology and Medicine 42
  
  Pages: 675-675
- Data Source
  KAKENHI-PROJECT-18790081
[Journal Article] Cholesterol is more susceptible to oxidation than linoleates in cultured2007
- Author(s)
  Y Saito, Y Yoshida, E Niki
- Journal Title
  
  FEBS Letters 581
  
  Pages: 4349-4354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790081
[Journal Article] 酸化ストレスから体を守るミネラル"セレン"2006
- Author(s)
  斎藤芳郎
- Journal Title
  
  バイオサイエンスとインダストリー 64
  
  Pages: 159-159
- NAID
  10017315830
- Data Source
  KAKENHI-PROJECT-18790081
[Journal Article] Turning point in apoptosis/necrosis induced by hydrogen peroxide2006
- Author(s)
  Yoshiro Saito*, Keiko Nishio, Yoko Ogawa, Junko Kimata, Tomoya Kinumi, Yasukazu Yoshida, Noriko Noguchi, Etsuo Niki
- Journal Title
  
  Free Radical Research 40
  
  Pages: 619-619
- Data Source
  KAKENHI-PROJECT-18790081
[Patent] セレノプロテインPを標的としたグリオブラストーマ治療薬2020
- Inventor(s)
  斎藤芳郎、杉浦あかり、外山喬士
- Industrial Property Rights Holder
  斎藤芳郎、杉浦あかり、外山喬士
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-171561
- Filing Date
  2020
- Data Source
  KAKENHI-PUBLICLY-20H05491
[Patent] セレノプロテインPの発現抑制剤およびその利用2017
- Inventor(s)
  斎藤芳郎、三田雄一郎、野口範子、内田理沙、安原小百合、横大路将
- Industrial Property Rights Holder
  斎藤芳郎、三田雄一郎、野口範子、内田理沙、安原小百合、横大路将
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K00882
[Patent] DJー１タンパク質産生促進用組成物2017
- Inventor(s)
  斎藤芳郎、野口範子、安藤万由
- Industrial Property Rights Holder
  斎藤芳郎、野口範子、安藤万由
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K00882
[Patent] DJー１タンパク質産生促進用組成物2017
- Inventor(s)
  斎藤芳郎、野口範子、安藤万由
- Industrial Property Rights Holder
  斎藤芳郎、野口範子、安藤万由
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K00882
[Patent] ２型糖尿病患者の治療薬選択の補助方法、治療薬の効果予測方法及び検査方法2014
- Inventor(s)
  御簾博文、金子周一、竹下有美枝、篁俊成、田中睦、斎藤芳郎
- Industrial Property Rights Holder
  御簾博文、金子周一、竹下有美枝、篁俊成、田中睦、斎藤芳郎
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-184499
- Filing Date
  2014-09-10
- Data Source
  KAKENHI-PROJECT-25292078
[Patent] ２型糖尿病の治療及び／又は予防薬2014
- Inventor(s)
  斎藤芳郎、吉岡佑弥、中山華穂、西藤有希奈、三田雄一郎、野口範子
- Industrial Property Rights Holder
  斎藤芳郎、吉岡佑弥、中山華穂、西藤有希奈、三田雄一郎、野口範子
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-165695
- Filing Date
  2014-08-18
- Data Source
  KAKENHI-PROJECT-25292078
[Patent] ２型糖尿病の治療及び／又は予防薬2013
- Inventor(s)
  斎藤芳郎、吉岡佑弥、中山華穂、西藤有希奈、三田雄一郎、野口範子
- Industrial Property Rights Holder
  斎藤芳郎、吉岡佑弥、中山華穂、西藤有希奈、三田雄一郎、野口範子
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-175612
- Filing Date
  2013-08-27
- Data Source
  KAKENHI-PROJECT-25292078
[Patent] 含硫アミノ酸残基が酸化された酸化型ポリペプチドに対する抗体2009
- Inventor(s)
  吉田康一, 斎藤芳郎, 小川陽子, 二木鋭雄, 七里元督, 浜窪隆雄, 望月康弘, 岩成宏子, 絹見直樹
- Industrial Property Rights Holder
  独立行政法人産業技術総合研究所、東京大学、株式会社ペルセウスプロテオミクス
- Industrial Property Number
  2009-028042
- Filing Date
  2009-02-10
- Data Source
  KAKENHI-PROJECT-19300256
[Patent] 含硫アミノ酸残基が酸化された酸化型ポリペプチドの製浩方法2006
- Inventor(s)
  斎藤芳郎, 絹見朋也, 西尾敬子, 小川陽子, 吉田康一, 二木鋭雄
- Industrial Property Rights Holder
  斎藤芳郎, 絹見朋也, 西尾敬子, 小川陽子, 吉田康一, 二木鋭雄
- Industrial Property Number
  2006-153039
- Filing Date
  2006-06-01
- Data Source
  KAKENHI-PROJECT-18790081
[Presentation] 抗酸化因子セレノプロテインＰの機能と疾患－両刃の剣としての必須微量元素セレン2021
- Author(s)
  斎藤芳郎
- Organizer
  日本農芸化学会2021大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05491
[Presentation] Janus Face of Antioxidative Selenoprotein P: Friend or Foe?2021
- Author(s)
  Yoshiro Saito
- Organizer
  Virtual 2021 Annual Meeting and ToxExpo
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H05491
[Presentation] レドックス制御因子セレノプロテインＰの発現制御と疾患2021
- Author(s)
  斎藤芳郎
- Organizer
  第1回レドックスR&D戦略委員会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05491
[Presentation] セレノプロテインＰを介した新規セレン輸送メカニズム2020
- Author(s)
  斎藤芳郎
- Organizer
  第７３回日本酸化ストレス学会／第２０回日本NO学会　合同学術集会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05491
[Presentation] 生命半金属セレンのダイナミクス制御機構の解明2020
- Author(s)
  斎藤芳郎
- Organizer
  フォーラム2020衛生薬学・環境トキシコロジー
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05491
[Presentation] セレンー硫黄代謝の接点およびクロストーク：生体内における識別とその制御2020
- Author(s)
  斎藤芳郎
- Organizer
  第47回　日本毒性学会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05491
[Presentation] 血漿セレン含有タンパク質セレノプロテインＰを標的とした生活習慣病の予防・治療法の開発2020
- Author(s)
  斎藤芳郎
- Organizer
  第61回　日本生化学会中国・四国支部例会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05491
[Presentation] 生体内レドックス制御因子セレノプロテインＰの機能と疾患2019
- Author(s)
  斎藤芳郎
- Organizer
  平成30年度文部科学省私立大学研究ブランディング事業・研究成果報告会・シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H03821
[Presentation] 脂質が誘導する小胞体ストレスとビタミンE2019
- Author(s)
  木村勇輝、浦野泰臣、斎藤芳郎、野口範子
- Organizer
  第30回ビタミンＥ研究会
- Data Source
  KAKENHI-PROJECT-16K00882
[Presentation] セレノプロテインPのレドックス制御機能と疾患―膵β細胞における二面性2018
- Author(s)
  斎藤芳郎
- Organizer
  第１５回　レドックス・ライフイノベーションシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H03821
[Presentation] 生活習慣病と抗酸化タンパク質セレノプロテインP：ホメオスタシスにおける活性酸素の功罪2018
- Author(s)
  斎藤芳郎
- Organizer
  第26回日本運動生理学大会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03821
[Presentation] Selenoprotein P as a significant regulator of Pancreatic beta cell function2018
- Author(s)
  Yoshiro Saito
- Organizer
  2018 Fall International Convention of The Pharmaceutical Society of Korea
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03821
[Presentation] ２型糖尿病の治療に新たな知見ー世界初　インスリン産生とインスリン抵抗性の両方を改善する物質を発見2018
- Author(s)
  斎藤芳郎
- Organizer
  第２回　同志社メディアセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17H03821
[Presentation] 膵β細胞モデルMIN6におけるセレン代謝とビタミンEの添加効果2018
- Author(s)
  斎藤芳郎、中尾昌平、稲荷尚吾、三田雄一郎、野口範子
- Organizer
  第２９回ビタミンE研究会
- Data Source
  KAKENHI-PROJECT-16K00882
[Presentation] Selenoprotein P as a significant redox regulator in vivo: implication of its excess and diabetes2018
- Author(s)
  Yoshiro Saito
- Organizer
  第91回日本生化学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03821
[Presentation] 血漿セレン含有タンパク質セレノプロテインＰ研究の新展開ーセレン代謝と疾患2018
- Author(s)
  斎藤芳郎
- Organizer
  メタルバイオサイエンス研究会2018
- Invited
- Data Source
  KAKENHI-PROJECT-17H03821
[Presentation] セレノプロテインＰのセレン運搬作用と膵β細胞のレドックス制御2018
- Author(s)
  斎藤芳郎
- Organizer
  日本薬学会　第128年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03821
[Presentation] 血漿セレン含有タンパク質セレノプロテインＰによる膵β細胞障害および中和抗体による抑制：糖尿病モデル動物への効果2018
- Author(s)
  斎藤芳郎、三田雄一郎、稲荷尚吾、長村尭浩、北原那美、御簾博文、篁俊成、野口範子
- Organizer
  第71回日本酸化ストレス学会・第18回日本NO学会合同学術集会
- Data Source
  KAKENHI-PROJECT-17H03821
[Presentation] Selenoprotein P as a regulator of pancreatic beta cell function: Improving effects of neutralizing antibody.2018
- Author(s)
  Yoshiro Saito, Yuichiro Mita, Shogo Inari, Takahiro Nagamura, Hirofumi Misu, Toshinari Takamura, and Noriko Noguchi
- Organizer
  19th SFRRI Biennial Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03821
[Presentation] 血漿セレン含有タンパク質セレノプロテインＰの機能と疾患ーレドックスバランスと膵β細胞の機能2017
- Author(s)
  斎藤芳郎
- Organizer
  第90回　日本生化学会・第40回　日本分子生物学会年会（ConBio2017）
- Invited
- Data Source
  KAKENHI-PROJECT-17H03821
[Presentation] 血漿セレン含有タンパク質セレノプロテインＰの膵β細胞における二面性2017
- Author(s)
  斎藤芳郎
- Organizer
  第28回　日本微量元素学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03821
[Presentation] 内在性long non-coding RNAによる新規Selenoprotein P翻訳制御メカニズム2016
- Author(s)
  三田雄一郎、斎藤芳郎、内田理沙、安原小百合、野口範子
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] セレノプロテインPの阻害抗体による糖尿病治療効果の解析―インスリン抵抗性および分泌能を改善する抗体医薬の開発2016
- Author(s)
  三田雄一郎、中山華穂、稲荷尚吾、西藤有希奈、吉岡佑弥、曽谷奏、高部稚子、御簾博文、篁俊成、高橋和彦、野口範子、斎藤芳郎
- Organizer
  日本糖尿病学会
- Place of Presentation
  国立京都国際会館（京都）
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] Selenoprotein P-neutralizing antibody ameliorates glucose intolerance and insulin resistance, insulin secretion2016
- Author(s)
  Shogo Inari, Yuichiro Mita, Kaho Nakayama, Wakako Takabe, Noriko Noguchi, and Yoshiro Saito
- Organizer
  SFRBM’s 23th Annual Meeting
- Place of Presentation
  San Francisco (USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] セレノプロテインＰによる膵β細胞死に対するビタミンＥの効果2016
- Author(s)
  斎藤芳郎、稲荷尚吾、三田雄一郎、高部稚子、御簾博文、篁俊成、野口範子
- Organizer
  第27回ビタミンＥ研究会
- Place of Presentation
  アルファあなぶきホール（高松）
- Year and Date
  2016-01-08
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] Jurkat細胞のSelenoprotein P取り込みに関与するApoER2の同定2016
- Author(s)
  堺菜穂子、三田雄一郎、吉岡佑弥、野口範子、斎藤芳郎
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] セレノプロテインＰと糖代謝ー膵β細胞の機能調節について2016
- Author(s)
  斎藤芳郎
- Organizer
  Metabolism Scientific Forum
- Place of Presentation
  ステーションコンファレンス東京（東京）
- Invited
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] 糖尿病関連タンパク質selenoprotein Pの翻訳を抑制する内在性long non-coding RNAの作用2016
- Author(s)
  内田理沙、三田雄一郎、安原小百合、斎藤芳郎、野口範子
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] 膵β細胞モデルMIN6がセレノプロテインPを産生する意義2016
- Author(s)
  中尾昌平、三田雄一郎、野口範子、斎藤芳郎
- Organizer
  日本生化学会
- Place of Presentation
  仙台国際センター（仙台）
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] Increased Selenoprotein P as a Therapeutic Target of Type 2 Diabetes2016
- Author(s)
  斎藤芳郎
- Organizer
  International Selenium Conference
- Place of Presentation
  Guangzhou (China)
- Year and Date
  2016-10-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] Selenoprotein Pの中和抗体によるインスリン抵抗性及び分泌能の改善2016
- Author(s)
  三田雄一郎、中山華穂、稲荷尚吾、西藤有希奈、吉岡佑弥、高部稚子、御簾博文、篁　俊成、野口範子、斎藤芳郎
- Organizer
  日本酸化ストレス学会
- Place of Presentation
  仙台国際センター（仙台）
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] セレン含有タンパク質が低下したSBP2変異患者におけるビタミンEの投与および投与中止に伴う変化2015
- Author(s)
  斎藤芳郎、七里元督、濱島崇、萩原義之、吉田康一、野口範子
- Organizer
  第26回ビタミンＥ研究会
- Place of Presentation
  東京
- Year and Date
  2015-01-10
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] Distribution of oxidized DJ-1 in human and mouse brain - Effects of aging process2015
- Author(s)
  Yoshiro SAITO, Yuichiro MITA, Kojiro HAYASHI, Takuma KASHI, Yuto KATAOKA, Asa IWASAKI, and Noriko NOGUCHI
- Organizer
  SFRBM 2015: SFRBM's 22nd Annual Meeting
- Place of Presentation
  Westin Boston Waterfront （ボストン）
- Year and Date
  2015-11-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25670084
[Presentation] 血漿セレン含有タンパク質セレノプロテインＰを標的とした２型糖尿病の抗体医薬の開発2015
- Author(s)
  斎藤芳郎、中山華穂、三田雄一郎、野口範子
- Organizer
  第67回日本ビタミン学会
- Place of Presentation
  奈良県新公会堂（奈良）
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] セレノプロテインPの発現・分泌に与える過酸化水素および抗酸化物質の影響2015
- Author(s)
  三田雄一郎、斎藤芳郎、野口範子
- Organizer
  第26回ビタミンＥ研究会
- Place of Presentation
  東京
- Year and Date
  2015-01-09
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] SBP2変異によるセレン含有タンパク質欠乏患者におけるコレステロールの酸化―細胞膜と血漿リポタンパク質の酸化反応の違い2015
- Author(s)
  斎藤芳郎、七里元督、濱島　崇、萩原義久、吉田康一、野口範子
- Organizer
  第57回　日本脂質生化学会
- Place of Presentation
  一橋大学一橋講堂（東京）
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] パーキンソン病モデルマウス脳内における酸化DJ-1の分布2015
- Author(s)
  橿　拓磨、片岡佑斗、林宏次朗、三田雄一郎、斎藤芳郎、野口範子
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学大会・合同大会（BMB2015）
- Place of Presentation
  神戸ポートアイランド（神戸）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25670084
[Presentation] 血漿セレン含有タンパク質セレノプロテインＰのレドックス制御機能ー2型糖尿病の治療標的として2015
- Author(s)
  斎藤芳郎
- Organizer
  第10回レドックス・ライフイノベーション第170委員会
- Place of Presentation
  慶応義塾大学先端生命科学研究所メタボロームキャンパスレクチャーホール（鶴岡）
- Year and Date
  2015-08-20
- Invited
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] 膵臓β細胞モデルMIN6は過剰なSelenoprotein Pにより障害を受ける2015
- Author(s)
  稲荷尚吾、高部稚子、三田雄一郎、御簾博文、篁俊成、野口範子、斎藤芳郎
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学大会・合同大会
- Place of Presentation
  神戸ポートアイランド（神戸）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] 各臓器における酸化DJ-1の分布と加齢に伴う変化2015
- Author(s)
  三田雄一郎、岩崎安紗、橿　拓磨、片岡佑斗、斎藤芳郎、野口範子
- Organizer
  第68回日本酸化ストレス学会
- Place of Presentation
  かごしま県民交流センター（鹿児島）
- Year and Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-25670084
[Presentation] パーキンソン病関連分子DJ-1のシステイン酸化体の検出法開発から早期診断への応用展開2015
- Author(s)
  斎藤芳郎
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  あわぎんホール(徳島市)
- Year and Date
  2015-06-24
- Invited
- Data Source
  KAKENHI-PROJECT-25670084
[Presentation] 血漿セレノプロテインＰによるセレン代謝制御と2型糖尿病2014
- Author(s)
  斎藤芳郎、吉岡佑弥、三田雄一郎、御簾博文、田中睦、篁俊成、野口範子
- Organizer
  第25回日本微量元素学会
- Place of Presentation
  岡山
- Year and Date
  2014-07-03
- Invited
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] Immunostaining of oxidized DJ-1 in human and mouse brain.2014
- Author(s)
  Yoshiro SAITO, Tomohiro MIYASAKA, Hiroyuki HATSUTA, Kazuko TAKAHASHI-NIKI, Hiroyoshi ARIGA, Shigeo MURAYAMA, Yasuo IHARA, Noriko NOGUCHI.
- Organizer
  Neuroscience 2014
- Place of Presentation
  ワシントンDC
- Year and Date
  2014-11-17
- Data Source
  KAKENHI-PROJECT-25670084
[Presentation] パーキンソン病関連タンパク質DJ-1の酸化による高分子化に関する研究2014
- Author(s)
  小林茉佑香、斎藤芳郎、菊地愛、村松香奈、野口範子
- Organizer
  第67回日本酸化ストレス学会
- Place of Presentation
  京都
- Year and Date
  2014-09-04
- Data Source
  KAKENHI-PROJECT-25670084
[Presentation] Enhancement of Oxidative Stress and Its Amelioration by Vitamin E in a Subject with Mutations in the Selenocysteine Insertion Sequence-Binding Protein 2 (SBP2) Gene.2014
- Author(s)
  Yoshiro Saito, Mototada Shichiri, Takashi Hamajima, and Noriko Noguch
- Organizer
  SFRBM’s 21th Annual Meeting
- Place of Presentation
  シアトル
- Year and Date
  2014-11-21
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] SBP2変異によるセレン含有蛋白質に対するビタミンEの効果―投与および投与中止に伴う脂質酸化物の変化2014
- Author(s)
  斎藤芳郎、七里元督、濱島崇、萩原義之、吉田康一、野口範子
- Organizer
  第17回Vitamin E Update Forum
- Place of Presentation
  東京
- Year and Date
  2014-08-06
- Invited
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] 酸化DJ-1特異的抗体を用いたマウスおよびヒト脳切片の免疫染色2014
- Author(s)
  斎藤芳郎、宮坂知宏、初田裕幸、仁木加寿子、有賀寛芳、村山繁雄、井原康夫、野口範子
- Organizer
  第37回日本神経科学会Neuroscience 2014
- Place of Presentation
  京都
- Year and Date
  2014-09-12
- Data Source
  KAKENHI-PROJECT-25670084
[Presentation] 脂肪肝患者におけるヘパトカインセレノプロテインＰ血中濃度と臓器別インスリン感受性の関連2014
- Author(s)
  加藤健一郎、御簾博文、田中睦、斎藤芳郎、竹下有美枝、金子周一、篁俊成
- Organizer
  第57回日本糖尿病学会
- Place of Presentation
  大阪
- Year and Date
  2014-05-23
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] 糖尿病関連タンパク質Selenoprotein Pの発現制御機構の解析2014
- Author(s)
  三田雄一郎、斎藤芳郎、野口範子
- Organizer
  第67回日本酸化ストレス学会
- Place of Presentation
  京都
- Year and Date
  2014-09-04
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] パーキンソン病関連分子DJ-1の細胞外分泌に及ぼすビタミンEの効果2014
- Author(s)
  斎藤芳郎、山本貴之、浦野泰臣、野口範子
- Organizer
  第25回ビタミンE研究会
- Place of Presentation
  米子
- Data Source
  KAKENHI-PROJECT-25670084
[Presentation] 血中の酸化型DJ-1異常高値の臨床的意義2014
- Author(s)
  西郷和真、斎藤芳郎、小川郁子、細井幸恵、三井良之、花田一志、上田昌美、石井一成、野口範子、楠進
- Organizer
  第67回日本酸化ストレス学会
- Place of Presentation
  京都
- Year and Date
  2014-09-04
- Data Source
  KAKENHI-PROJECT-25670084
[Presentation] セレノプロテインＰは分解経路・非分解経路を介して細胞内へセレンを供給する2014
- Author(s)
  吉岡佑弥、三田雄一郎、西藤有希奈、野口範子、斎藤芳郎
- Organizer
  第87回日本生化学会
- Place of Presentation
  京都
- Year and Date
  2014-10-18
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] PDの診断マーカーである血中oxDJ-1の異常高値を示したDLBの4例2014
- Author(s)
  西郷和真、斎藤芳郎、小川郁子、細井幸恵、三井良之、花田一志、上田昌美、石井一成、野口範子、楠進
- Organizer
  第33回日本認知症学会
- Place of Presentation
  横浜
- Year and Date
  2014-12-01
- Data Source
  KAKENHI-PROJECT-25670084
[Presentation] パーキンソン病モデルマウス脳内におけるDJ-1の酸化2014
- Author(s)
  橿拓磨、斎藤芳郎、林宏次朗、三田雄一郎、片岡佑斗、野口範子
- Organizer
  第67回日本酸化ストレス学会
- Place of Presentation
  京都
- Year and Date
  2014-09-04
- Data Source
  KAKENHI-PROJECT-25670084
[Presentation] 抗酸化ヘパトカインセレノプロテインPはVEGFを介して糖尿病性血管新生障害に寄与する2014
- Author(s)
  御簾博文、石倉和秀、斎藤芳郎、金子周一、篁　俊成
- Organizer
  第67回日本酸化ストレス学会
- Place of Presentation
  京都
- Year and Date
  2014-09-05
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] Study of selenium supply mechanism of selenoprotein P using 75Se and immunological methods2013
- Author(s)
  Yoshiro Saito, Yuuya Yoshioka, Yuichiro Mita, Kaho Nakayama, Yukina Nishito, Kazuhiko Takahashi, Noriko Noguchi
- Organizer
  10th International Symposium on Selenium in Biology and Medicine
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] セレン欠乏に伴う酸化ストレス障害に対するビタミンEの効果-SBP2遺伝子異常に対する治療への応用2013
- Author(s)
  斎藤芳郎、七里元督、濱島　崇、萩原義久、吉田康一、野口範子
- Organizer
  第65回ビタミン学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] 7-hydroxycholestrol as a possible biomarker of cellular lipid peroxidation- difference between cellular and plasma lipid peroxidation2013
- Author(s)
  Yoshiro Saito, Noriko Noguchi
- Organizer
  3rd ENOR Symposium Oxysterols: Markers and Pathways
- Place of Presentation
  Swansea, UK
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] パーキンソン病関連分子DJ-1の酸化に伴う高分子化およびシステインの役割に関する研究2013
- Author(s)
  小林茉佑香、村松香奈、斎藤芳郎、野口範子
- Organizer
  第66回日本酸化ストレス学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25670084
[Presentation] Oxidation of DJ-1 in the brain of Parkinson disease patients-possible biomarker for diagnosis of Parkinson disease at early stage2013
- Author(s)
  Yoshiro Saito, Tomohiro Miyasaka, Takao Hamakubo, Etsuo Niki, and Noriko Noguchi
- Organizer
  Neuro2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25670084
[Presentation] 細胞内および脳内における酸化DJ-1の分布に関する研究2013
- Author(s)
  林宏次朗、斎藤芳郎、宮坂知宏、仁木加寿子、有賀寛芳、野口範子
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25670084
[Presentation] 新規糖尿病バイオマーカーを標的とする２型糖尿病治療薬2013
- Author(s)
  斎藤芳郎
- Organizer
  イノベーション・ジャパン2013
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] SBP2遺伝子異常に伴う酸化ストレスに対するビタミンEの効果- コレステロール酸化物による脂質酸化の評価2013
- Author(s)
  斎藤芳郎、七里元督、濱島　崇、萩原義久、吉田康一、野口範子
- Organizer
  第16回Vitamin E Update Forum
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] 75Seおよび免疫学的手法を用いたセレノプロテインＰのセレン運搬機構の解析2013
- Author(s)
  吉岡佑弥、西藤有希奈、三田雄一郎、高橋和彦、野口範子、斎藤芳郎
- Organizer
  第86回日本生化学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] 酸化DJ-1とパーキンソン病(2)臨床検体の測定2009
- Author(s)
  小川陽子, 斎藤芳郎, 吉田康一, 二木鋭雄
- Organizer
  第62回日本酸化ストレス学会学術総会
- Year and Date
  2009-06-11
- Data Source
  KAKENHI-PROJECT-19300256
[Presentation] 酸化DJ-1とパーキンソン病(1)抗体作成とELISA開発2009
- Author(s)
  斎藤芳郎, 小川陽子, 吉田康一, 二木鋭雄
- Organizer
  第62回日本酸化ストレス学会学術総会
- Year and Date
  2009-06-11
- Data Source
  KAKENHI-PROJECT-19300256
[Presentation] Adaptive Response Induced by Lipid Oxidation Products: Novel Meaning of Oxidative Stress2008
- Author(s)
  斎藤芳郎
- Organizer
  6th International Workshop on the Molecular Biology of Stress Responses
- Place of Presentation
  バンコク、タイ
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-18790081

1. NOGUCHI Noriko (40198578)

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18. ISHII Kiyoaki

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Saito Yoshiro 斎藤 芳郎

Yoshiro Saito 斎藤 芳郎

SAITO Yoshiro 斎藤 芳郎

斎藤 芳郎 サイトウ ヨシロウ

Research Projects

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Co-Researchers

超硫黄分子とセレンのクロストークによるシグナル伝達制御Principal Investigator

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Creation of "disease metallomics" to understand the relationship between fluctuations of heavy metals/trace elements and diseasesPrincipal Investigator

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Regulatory mechanism of selenoprotein P expression and its deterioration mechanism of glucose metabolismPrincipal Investigator

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Elucidation of a dynamics control mechanism of seleniumPrincipal Investigator

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Omics analysis for the establishment of "reductive stress," a biological disorder caused by excessive antioxidant and reductive environmentPrincipal Investigator

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Fatigue assessment and analysis of trace element deficiency and eating habits survey for prevention of mental health disorder of university students

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Molecular mechanisms of disorder of pancreatic beta cells induced by excess selenoprotein PPrincipal Investigator

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Mechanism of inhibition of oxysterol-induced Alzheimer's disease by vitamin E

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Selenium-transport mechanism of selenoprotein PPrincipal Investigator

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Development of diagnosis and treatment of Parkinson disease at early stage using novel biomarker oxidized DJ-1Principal Investigator

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The study on functional food using oxidative stress marker, hydroxyoctadecadienoic acid and 7-hydroxycholesterol

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培養神経細胞および幼若ラット脳を用いたドーパミン神経障害メカニズムの探究Principal Investigator

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酸化血清中に存在する細胞傷害因子の探索-新規酸化ストレスマーカーの同定を目指してPrincipal Investigator

Saito Yoshiro 斎藤芳郎

Yoshiro Saito 斎藤芳郎

SAITO Yoshiro 斎藤芳郎

斎藤芳郎サイトウヨシロウ

[Book] レドックス疾患学　セレノプロテインPによるレドックス制御と2型糖尿病2018

[Book] 別冊「医学のあゆみ」レドックスUPDATE ストレス制御の臨床医学・健康科学2015

[Book] パーキンソン病と酸化ストレス　酸化ストレスの医学、第2版2014