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Nagai Yoshitaka  永井 義隆

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NAGAI Yoshitaka  永井 義隆

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Researcher Number 60335354
Other IDs
Affiliation (Current) 2023: 近畿大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2020 – 2023: 近畿大学, 医学部, 教授
2016 – 2021: 大阪大学, 医学系研究科, 寄附講座教授
2017: 大阪大学, 医学(系)研究科(研究院), 教授
2016: 大阪大学, 医学(系)研究科(研究院), 寄附講座教授
2016: 大阪大学, 医学系研究科, 教授 … More
2016: 大阪大学, 医学部, 教授
2016: 大阪大学, 大学院医学系研究科, 教授
2015: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 疾病研究第四部, 客員研究員
2015: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 客員研究員
2015: 大阪大学, 大学院医学系研究科神経難病認知症探索治療学寄附講座, 教授
2014: 独立行政法人国立精神, 神経医療研究センター・疾病研究第4部, 室長
2013 – 2014: 独立行政法人国立精神・神経医療研究センター, 神経研究所 疾病研究第4部, 室長
2009 – 2014: National Center of Neurology and Psychiatry, 神経研究所疾病研究第四部, 室長
2013: 独立行政法人国立精神・神経医療研究センター, 神経研究所, 室長
2012: (独)国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 室長
2012: 独立行政法人国立精神, 神経医療センター, 疾病研究第4部.室長
2009 – 2012: National Center of Neurology and Psychiatry, 神経研究所・疾病研究第四部, 室長
2008: National Center of Neurology and Psychiatry, 神経研究所・疾病研究第四部, 室長
2008: National Center of Neurology and Psychiatry, 神経研究所疾病研究第四部, 室長
2007: Osaka University, 医学糸研究科, 准教授
2007: Osaka University, 医学系研究科, 准教授
2002 – 2006: 大阪大学, 医学系研究科, 助手 Less
Review Section/Research Field
Principal Investigator
Biological Sciences / Neurology / Basic Section 52020:Neurology-related / Transformative Research Areas, Section (III) / General internal medicine and related fields / Neurology / Science and Engineering
Except Principal Investigator
Neurology / Basic Section 52020:Neurology-related / Basic Section 51030:Pathophysiologic neuroscience-related … More / Medium-sized Section 52:General internal medicine and related fields / Human genetics / Nerve anatomy/Neuropathology / Laboratory animal science / Structural biochemistry Less
Keywords
Principal Investigator
脳神経疾患 / 神経科学 / 蛋白質 / ポリグルタミン病 / 神経変性疾患 / 遺伝子 / アミロイド / ショウジョウバエ / 分子治療 / RNA … More / 神経機能障害 / 分子シャペロン / 治療 / タンパク質 / 痴呆 / 認知症 / Polyglutamine diseases / Neurodegenerative diseases / Neurological diseases / Protein / Neuroscience / Gene / シナプス / 分子デザイン / 蛋白質分解 / 治療薬 / ストレス / スクリーニング / 遺伝学 / 遺伝子治療 / 非膜性オルガネラ / 液-液相分離 / RNA翻訳 / RAN翻訳 / ＲＮＡ / エクソソーム / 質量分析顕微鏡 / 質量顕微鏡 / 分析科学 / 脂質 / Neuronal dysfunction / Drosophila / Amyloid / Molecular therapy / マーモセット / 霊長類 / 疾患モデル / イメージング / ２光子レーザー顕微鏡 / RNA結合蛋白質 / リピートRNA / ALS / ペプチド / 凝集 / プリオン / 感染 / QBP1 / オリゴマー / βシート / 遣伝子 / トランスポーター / ショウジョウバェ / トランスポゾン / 核酸 / 転写 / 発現制御 / 筋ジストロフィー / ボリグルタミン病 / 伝播性 / 高分子構造・物性 … More
Except Principal Investigator
パーキンソン病 / 神経変性疾患 / αシヌクレイン / 筋萎縮性側索硬化症 / 前頭側頭葉変性症 / TDP-43 / シヌクレイノパチー / 局所翻訳 / mRNA / ショウジョウバエ / 神経変性 / マイクロRNA / SNP / 多系統萎縮症 / α-シヌクレイン / エンドソーム / 小胞輸送 / プリオン仮説 / ポリグルタミン病 / 認知症 / レビ-小体型認知症 / 血液バイオマーカー / 酸化型　DJ-1 / 神経軸索 / プロテオスタシス / 細胞内小器官相互作用 / 蛋白質品質管理 / 蛋白質の品質管理機構 / 凝集 / 伝播 / 神経遺伝 / 疾患モデル / 遺伝子改変 / TETシステム / トランスジェニック / マーモセット / 異常蛋白伝播 / コンディショナルノックアウトマウス / 異常タンパク凝集 / ESCRT / アクチン / DNAJC13 / メンブレントラフィック / ショウジョウバエモデル / アルファシヌクレイン / カテプシンD / レトロマー / VPS35 / PARK17 / リボソーム蛋白質mRNA / リボソーム蛋白質 / 軸索輸送 / 神経突起輸送 / α‐シヌクレイン / 多重重複変異 / RNAi / RNA代謝 / 筋委縮性側索硬化症 / 細胞死 / 酸化ストレス / ストレス顆粒 / 前頭側頭型認知症 / 神経科学 / 細胞間伝播 / オリゴデンドログリア / 神経細胞 / エンドサイトーシス / セルトラリン / ダイナミン / エキソソーム / 異常凝集タンパク / 神経突起 / RNA / アミロイド / コンフォメーション伝播 / バイオマーカー / ポルグルタミン病 Less

  • Research Projects

    (45 results)

  • Research Products

    (863 results)

  • Co-Researchers

    (46 People)

  •  The Blood Diagnostic Markers in Dementia with Lewy Bodies

    • Principal Investigator
      西郷 和真
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Kindai University

  •  Genomic Medical Research as a basis for for Parkinson's Disease

    • Principal Investigator
      佐竹 渉
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      The University of Tokyo

  •  Elucidation of regulation mechanisms of LLPS leading to pathological protein aggregation in neurodegenerative diseasesPrincipal Investigator

    • Principal Investigator
      永井 義隆
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Kindai University

  •  Elucidation of the pathogenesis and development of the treatment strategy of ALS/FTLD focusing on the local translation in neuronal axons

    • Principal Investigator
      長野 清一
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Osaka University

  •  Elucidation of molecular mechanisms of repeat-associated non-AUG translation and its role in neurodegenerative diseasesPrincipal Investigator

    • Principal Investigator
      永井 義隆
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      Kindai University

  •  Exploration of master genes for disease transmission in synucleinopathies

    • Principal Investigator
      Sugie Atsushi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Niigata University

  •  Studies on nuclear protein homeostasis in neurodegenerative diseases

    • Principal Investigator
      津田 浩史
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      Osaka University

  •  Elucidation of mechanisms of prionoid conversion of alpha-synuclein by imaging mass spectrometryPrincipal Investigator

    • Principal Investigator
      Nagai Yoshitaka
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      General internal medicine and related fields
    • Research Institution
      Osaka University

  •  RNA結合タンパク質による異常RNA蓄積に対するリボスターシス維持機構の解明Principal Investigator

    • Principal Investigator
      永井 義隆
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University

  •  パーキンソン病の包括的ゲノム解析による遺伝背景解明と応用

    • Principal Investigator
      佐竹 渉
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Human genetics
    • Research Institution
      The University of Tokyo
      Kobe University

  •  Investigation of ALS/FTLD pathogenesis based on translational deterioration due to ribosome dysfunction in axons

    • Principal Investigator
      NAGANO Seiichi
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Osaka University

  •  Investigation of the role of exosome-mediated maintenance of proteostasis in neurodegenerative diseases.Principal Investigator

    • Principal Investigator
      Nagai Yoshitaka
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Osaka University

  •  Establishment and pathological analyses of transgenic marmoset models of polyglutamine diseasesPrincipal Investigator

    • Principal Investigator
      NAGAI Yoshitaka
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry

  •  Zeroing in on aberrant membrane trafficking in molecular pathogenesis of Parkinson's disease

    • Principal Investigator
      Hasegawa Takafumi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Tohoku University

  •  Generation of transgenic monkey with tetracyclin-inducible gene expression system for neurodegenerative disease model.

    • Principal Investigator
      TOMIOKA Ikuo
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Laboratory animal science
      Nerve anatomy/Neuropathology
    • Research Institution
      Shinshu University

  •  Effects of microRNA on the risk of sporadic Parkinson disease associated with NACP-Rep1 polymorphic site

    • Principal Investigator
      Mizuno Hideya
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Mukogawa Women's University

  •  シナプス発達障害仮説に基づいた神経変性疾患における機能障害発現メカニズムの解明Principal Investigator

    • Principal Investigator
      永井 義隆
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      National Center of Neurology and Psychiatry

  •  Pathogenesis of TDP-43 proteinopathy based on the transport defect of target mRNA

    • Principal Investigator
      Nagano Seiichi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry

  •  Research toward the development of a novel treatment for Parkinson disease by a moderate gene silencing with RNA interference.

    • Principal Investigator
      HOHJOH HIROHIKO
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry

  •  A gain of toxic function hypothesis via accumulated RNA-binding protein and repeat RNA in the pathogenesis of ALS and its validation in vivoPrincipal Investigator

    • Principal Investigator
      NAGAI Yoshitaka
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      独立行政法人国立精神・神経医療研究センター

  •  神経変性疾患におけるシナプス機能異常に着目した神経機能障害メカニズムの解明Principal Investigator

    • Principal Investigator
      永井 義隆
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      National Center of Neurology and Psychiatry

  •  Therapeutic strategy for the polyglutamine diseases by selective degradation of expanded polyglutamine proteins using polyglutamine-binding pepetidesPrincipal Investigator

    • Principal Investigator
      NAGAI Yoshitaka
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry

  •  Analysis of molecular mechanisms behind the prion hypothesis in synucleinopathy

    • Principal Investigator
      HASEGAWA Takafumi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Tohoku University

  •  The effects of a SNP in 3'UTR on the microRNA-mediated regulation of aipha-Synuclein gene

    • Principal Investigator
      MIZUNO Hideya
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Mukogawa Women's University

  •  Investigation of effect of TDP-43 aggregation on translational control

    • Principal Investigator
      HIGASHI Shinji
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurology
    • Research Institution
      公益財団法人東京都医学総合研究所
      Tokyo Metropolitan Organization for Medical Research

  •  アミロイド性タンパク質凝集体の細胞間・個体間の伝播・感染メカニズムの解明Principal Investigator

    • Principal Investigator
      永井 義隆
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      National Center of Neurology and Psychiatry

  •  Elucidation of the neuronal toxicity mechanism by TDP-43 based on dysfunction of the nucleocytoplasmic shuttling

    • Principal Investigator
      NAGANO Seiichi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry

  •  Development of a drug for the polyglutamine diseases by molecular design of chemical analogues of the aggregation inhibitor peptide QBP1Principal Investigator

    • Principal Investigator
      NAGAI Yoshitaka
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry

  •  神経変性疾患におけるタンパク質分解経路間のクロストークの個体レベルでの統合的理解Principal Investigator

    • Principal Investigator
      永井 義隆
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      National Center of Neurology and Psychiatry

  •  Demonstration of the abnormal conformational transition of amyloid proteins and it's application as an early diagnostic tool

    • Principal Investigator
      POPIEL HELENA Akiko
    • Project Period (FY)
      2009 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
    • Research Field
      Structural biochemistry
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry

  •  ポリグルタミン病における可逆性神経機能障害の分子メカニズムの解明Principal Investigator

    • Principal Investigator
      永井 義隆
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      National Center of Neurology and Psychiatry

  •  SLC7ファミリーが関わる神経変性疾患ポリグルタミン病の病態解明と治療法開発Principal Investigator

    • Principal Investigator
      永井 義隆
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      National Center of Neurology and Psychiatry

  •  ミスフォールディング病に対する内在性分子シャペロン発現誘導による治療法開発Principal Investigator

    • Principal Investigator
      永井 義隆
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      National Center of Neurology and Psychiatry

  •  Molecular therapy for the polyglutamine diseases targeting the toxic β-sheet conformers and oligomersPrincipal Investigator

    • Principal Investigator
      NAGAI Yoshitaka
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry

  •  福山型筋ジストロフィーのレトロトランスポゾンによるmRNA転写障害解明と治療開発Principal Investigator

    • Principal Investigator
      永井 義隆
    • Project Period (FY)
      2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Osaka University

  •  ポリグルタミン病に対する凝集阻害低分子による治療法開発Principal Investigator

    • Principal Investigator
      永井 義隆
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University

  •  アミロイド性蛋白質のコンフォメーション変移とその伝播性の解明Principal Investigator

    • Principal Investigator
      永井 義隆
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      Osaka University

  •  ポリグルタミン病に対する凝集阻害ペプチドの遺伝子治療と凝集阻害薬のスクリーニングPrincipal Investigator

    • Principal Investigator
      永井 義隆
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University

  •  ポリグルタミンタンパク質のアミロイド形成機構の解明とその阻害薬のスクリーニングPrincipal Investigator

    • Principal Investigator
      永井 義隆
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University

  •  Screening for modifier genes of polyglutamine-induced neuronal dysfunction using a Drosophila polyglutamine disease model.Principal Investigator

    • Principal Investigator
      NAGAI Yoshitaka
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Osaka University

  •  ポリグルタミン病に対する分子治療の試みと治療薬のハイスループットスクリーニングPrincipal Investigator

    • Principal Investigator
      永井 義隆
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University

  •  ポリグルタミン病に対する分子治療法の確立と治療薬のハイスループットスクリーニングPrincipal Investigator

    • Principal Investigator
      永井 義隆
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University

  •  ポリグルタミンタンパク質の構造解析と凝集阻害薬のハイスループットスクリーニングPrincipal Investigator

    • Principal Investigator
      永井 義隆
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University

  •  ポリグルタミン病に対する分子治療法の確立Principal Investigator

    • Principal Investigator
      永井 義隆
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University

  •  Establishment of a molecular therapy for neurodegenerative diseases including the polyglutamine diseases.Principal Investigator

    • Principal Investigator
      NAGAI Yoshitaka
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Osaka University

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  • [Book] 現代化学増刊46「相分離生物学の全貌」2020
    • Author(s)
      上山盛夫、永井義隆
    • Publisher
      東京化学同人
    • Data Source
      KAKENHI-PLANNED-20H05927

  • [Book] 現代化学増刊46「相分離生物学の全貌」2020
    • Author(s)
      小澤大作、永井義隆
    • Publisher
      東京化学同人
    • Data Source
      KAKENHI-PLANNED-20H05927

  • [Book] タンパク質のアモルファス凝集と溶解性―基礎研究からバイオ産業・創薬研究への応用まで－2019
    • Author(s)
      小澤大作、武内敏秀、永井義隆
    • Total Pages
      283
    • Publisher
      シーエムシー出版
    • ISBN
      9784781313979
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Book] タンパク質のアモルファス凝集と溶解性―基礎研究からバイオ産業・創薬研究への応用まで－2019
    • Author(s)
      小澤大作、武内敏秀、永井義隆
    • Total Pages
      283
    • Publisher
      シーエムシー出版
    • ISBN
      9784781313979
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Book] タンパク質のアモルファス凝集と溶解性―基礎研究からバイオ産業・創薬研究への応用まで－2019
    • Author(s)
      小澤大作、武内敏秀、永井義隆
    • Total Pages
      283
    • Publisher
      シーエムシー出版
    • ISBN
      9784781313979
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Book] パラダイムシフトをもたらすエクソソーム機能研究最前線2017
    • Author(s)
      武内敏秀、永井義隆
    • Total Pages
      282
    • Publisher
      エヌ・ティー・エス
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Book] 動物／疾患モデルの作製技術・病態解析・評価手法2017
    • Author(s)
      永井 義隆 他
    • Total Pages
      428
    • Publisher
      技術情報協会
    • ISBN
      9784861046650
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Book] 動物／疾患モデルの作製技術・病態解析・評価手法2017
    • Author(s)
      皆川栄子、永井義隆
    • Total Pages
      428
    • Publisher
      技術情報協会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Book] Heat Shock Factor2016
    • Author(s)
      Fujikake N., Takeuchi T., Nagai Y.
    • Total Pages
      301
    • Publisher
      Springer Publishers, Inc.
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Book] 実験医学 別冊「マウス表現型解析スタンダード」2016
    • Author(s)
      長野清一、金井雅裕、永井義隆
    • Total Pages
      347
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Book] HSF1 activation by small chemical compounds for the treatment of neurodegenerative diseases In Heat Shock Factor2016
    • Author(s)
      Fujikake N., Takeuchi T., *Nagai Y.
    • Total Pages
      301
    • Publisher
      Springer Publishers, Inc.
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Book] 実験医学別冊「マウス表現型解析スタンダード」2016
    • Author(s)
      長野清一，金井雅裕，永井義隆．
    • Total Pages
      351
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-16K09690

  • [Book] Drug development for neurodegenerative diseases In Neurodegenerative Disorders as Systemic Diseases2015
    • Author(s)
      Nagai Y., Minakawa E. N.
    • Total Pages
      304
    • Publisher
      Springer Publishers, Inc.
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Book] ＜アクチュアル 脳・神経疾患の臨床⑤＞「小脳と運動失調」2013
    • Author(s)
      永井義隆
    • Total Pages
      10
    • Publisher
      中山書店
    • Data Source
      KAKENHI-PUBLICLY-23110528

  • [Book] ＜アクチュアル 脳・神経疾患の臨床⑤＞「小脳と運動失調」2013
    • Author(s)
      永井義隆
    • Total Pages
      10
    • Publisher
      中山書店
    • Data Source
      KAKENHI-PROJECT-23390237

  • [Book] ポリグルタミン鎖の伸長によるSCA.<アクチュアル脳・神経疾患の臨床⑤>「小脳と運動失調」(西澤正豊編)2013
    • Author(s)
      永井義隆
    • Publisher
      中山書店
    • Data Source
      KAKENHI-PROJECT-24659438

  • [Book] ＜アクチュアル 脳・神経疾患の臨床⑤＞「小脳と運動失調」2013
    • Author(s)
      永井義隆
    • Total Pages
      10
    • Publisher
      中山書店
    • Data Source
      KAKENHI-PROJECT-24659438

  • [Book] ポリグルタミン鎖の伸長によるSCA.<アクチュアル脳・神経疾患の臨床⑤>「小脳と運動失調」2013
    • Author(s)
      永井義隆
    • Publisher
      中山書店
    • Data Source
      KAKENHI-PROJECT-23390237

  • [Book] 稀少疾患・難病の診断／治療技術と製品開発2012
    • Author(s)
      永井義隆、和田圭司
    • Total Pages
      7
    • Publisher
      技術情報協会
    • Data Source
      KAKENHI-PROJECT-23390237

  • [Book] 稀少疾患・難病の診断／治療技術と製品開発2012
    • Author(s)
      永井義隆、和田圭司
    • Total Pages
      7
    • Publisher
      技術情報協会
    • Data Source
      KAKENHI-PROJECT-24659438

  • [Book] ハンチントン病.稀少疾患・難病の診断/治療技術と製品開発2012
    • Author(s)
      永井義隆、和田圭司
    • Publisher
      技術情報協会
    • Data Source
      KAKENHI-PROJECT-24659438

  • [Book] ハンチントン病.稀少疾患・難病の診断/治療技術と製品開発2012
    • Author(s)
      永井義隆, 和田圭司
    • Publisher
      技術情報協会
    • Data Source
      KAKENHI-PROJECT-23390237

  • [Book] 稀少疾患・難病の診断／治療技術と製品開発2012
    • Author(s)
      永井義隆、和田圭司
    • Total Pages
      7
    • Publisher
      技術情報協会
    • Data Source
      KAKENHI-PUBLICLY-23110528

  • [Book] 神経変性疾患のサイエンス2007
    • Author(s)
      永井義隆, 他
    • Total Pages
      251
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-19659226

  • [Book] 神経変性疾患のサイエンス2007
    • Author(s)
      永井義隆, 他
    • Total Pages
      251
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-18031024

  • [Book] 神経変性疾患のサイエンス2007
    • Author(s)
      永井義隆, 他
    • Total Pages
      251
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-18023025

  • [Journal Article] Protein aggregation inhibitors as disease-modifying therapies for polyglutamine diseases.2021
    • Author(s)
      *Minakawa E.N., *Nagai Y.
    • Journal Title

      Front. Neurosci.

      Volume: 15 Pages: 621996-621996

    • DOI

      10.3389/fnins.2021.621996

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-20H05927

  • [Journal Article] Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model2021
    • Author(s)
      Shibata Tomonori、Nagano Konami、Ueyama Morio、Ninomiya Kensuke、Hirose Tetsuro、Nagai Yoshitaka、Ishikawa Kinya、Kawai Gota、Nakatani Kazuhiko
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 1-13

    • DOI

      10.1038/s41467-020-20487-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K06478, KAKENHI-PROJECT-19K22254, KAKENHI-PROJECT-19H00924, KAKENHI-PROJECT-17K01962, KAKENHI-PLANNED-20H05927, KAKENHI-PROJECT-20H00448, KAKENHI-PROJECT-20H02880

  • [Journal Article] Divergent CPEB prion-like domains reveal different assembly mechanisms for a generic amyloid-like fold2021
    • Author(s)
      Hervas R, Fernandez-Ramirez MC, Galera-Prat A, Suzuki M, Nagai Y, Bruix M, Menendez M, Laurents DV, Carrion-Vazquez M
    • Journal Title

      BMC Biology

      Volume: 19 Issue: 1 Pages: 1-14

    • DOI

      10.1186/s12915-021-00967-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07987, KAKENHI-PLANNED-20H05927

  • [Journal Article] 神経変性疾患とエクソソーム2020
    • Author(s)
      武内敏秀、永井義隆
    • Journal Title

      医学のあゆみ

      Volume: 272 Pages: 319-324

    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Journal Article] Arginine is a disease modifier for polyQ disease models that stabilizes polyQ protein conformation.2020
    • Author(s)
      Minakawa EN, Popiel HA, Tada M, Takahashi T, Yamane H, Saitoh Y, Takahashi Y, Ozawa D, Takeda A, Takeuchi T, Okamoto Y, Yamamoto K, Suzuki M, Fujita H, Ito C, Yagihara H, Saito Y, Watase K, Adachi H, Katsuno M, Mochizuki H, Shiraki K, Sobue G, Toda T, Wada K, Onodera O, Nagai Y.
    • Journal Title

      Brain

      Volume: 143 Issue: 6 Pages: 1811-1825

    • DOI

      10.1093/brain/awaa115

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07970, KAKENHI-PROJECT-19K07987, KAKENHI-PROJECT-20K07737, KAKENHI-PROJECT-17K09755, KAKENHI-PLANNED-20H05927

  • [Journal Article] Generation of common marmoset model lines of spinocerebellar ataxia type 3.2020
    • Author(s)
      Tomioka I., Nagai Y., Seki K.
    • Journal Title

      Front. Neurosci.

      Volume: 14 Pages: 548002-548002

    • DOI

      10.3389/fnins.2020.548002

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-20H05927

  • [Journal Article] ショウジョウバエモデルを用いたALSの病態解明と治療法開発2020
    • Author(s)
      田港朝也、永井義隆
    • Journal Title

      医学のあゆみ

      Volume: 272 Pages: 535-540

    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Journal Article] ショウジョウバエモデルを用いたALSの病態解明と治療法開発2020
    • Author(s)
      田港朝也、永井義隆
    • Journal Title

      医学のあゆみ

      Volume: 272 Pages: 535-540

    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Journal Article] 神経変性疾患とエクソソーム2020
    • Author(s)
      武内敏秀、永井義隆
    • Journal Title

      医学のあゆみ

      Volume: 272 Pages: 319-324

    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Journal Article] ショウジョウバエモデルを用いたALSの病態解明と治療法開発2020
    • Author(s)
      田港朝也、永井義隆
    • Journal Title

      医学のあゆみ

      Volume: 272 Pages: 535-540

    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Journal Article] The secondary structural difference between Lewy body and glial cytoplasmic inclusion in autopsy brain with synchrotron FTIR micro-spectroscopy2020
    • Author(s)
      Araki Katsuya、Yagi Naoto、Ikemoto Yuka、Hayakawa Hideki、Fujimura Harutoshi、Moriwaki Taro、Nagai Yoshitaka、Murayama Shigeo、Mochizuki Hideki
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 1-100

    • DOI

      10.1038/s41598-020-76565-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02741, KAKENHI-PLANNED-20H05927

  • [Journal Article] Alternative mitochondrial quality control mediated by extracellular release2020
    • Author(s)
      Choong Chi-Jing、Okuno Tatsusada、Ikenaka Kensuke、Baba Kousuke、Hayakawa Hideki、Koike Masato、Yokota Mutsumi、Doi Junko、Kakuda Keita、Takeuchi Toshihide、Kuma Akiko、Nakamura Shuhei、Nagai Yoshitaka、Nagano Seiichi、Yoshimori Tamotsu、Mochizuki Hideki
    • Journal Title

      Autophagy

      Volume: － Issue: 10 Pages: 1-13

    • DOI

      10.1080/15548627.2020.1848130

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07743, KAKENHI-PROJECT-19K22429, KAKENHI-PLANNED-20H05927, KAKENHI-PROJECT-16H06280

  • [Journal Article] 神経変性疾患とエクソソーム2020
    • Author(s)
      武内敏秀、永井義隆
    • Journal Title

      医学のあゆみ

      Volume: 272 Pages: 319-324

    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Journal Article] Go-sha-jinki-Gan Alleviates Inflammation in Neurological Disorders via p38-TNF Signaling in the Central Nervous System2020
    • Author(s)
      Shiying Jiang, Kousuke Baba, Tatsusada Okuno, Makoto Kinoshita, Chi-Jing Choong, Hideki Hayakawa, Hiroshi Sakiyama, Kensuke Ikenaka, Seiichi Nagano, Tsutomu Sasaki, Munehisa Shimamura, Yoshitaka Nagai, Keisuke Hagihara, Hideki Mochizuki
    • Journal Title

      Neurotherapeutics

      Volume: 17 Issue: 1 Pages: 1-14

    • DOI

      10.1007/s13311-020-00948-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07937, KAKENHI-PROJECT-17K09299, KAKENHI-PLANNED-20H05927, KAKENHI-PROJECT-20K07865

  • [Journal Article] Molecular mechanisms and future therapeutics for spinocerebrellar ataxia type 31 (SCA31).2019
    • Author(s)
      *Ishikawa K., Nagai Y.
    • Journal Title

      Neurotherapeutics

      Volume: 16 Issue: 4 Pages: 1106-1114

    • DOI

      10.1007/s13311-019-00804-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19658, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325, KAKENHI-PROJECT-18H02715

  • [Journal Article] Arylsulfatase A, a genetic modifier of Parkinson's disease, is an α-synuclein chaperone.2019
    • Author(s)
      J. S. Lee, K. Kanai, M. Suzuki, W. S. Kim, H. S. Yoo, Y. Fu, D-K. Kim, B. C. Jung, M. Choi, K. W. Oh, Y. Li, M. Nakatani, T. Nakazato, S. Sekimoto, M. Furuyama, H. Yoshino, S. Kubo, K. Nishioka, R. Sakai, M. Ueyama, H. Mochizuki, H-J. Lee, S. P. Sardi, G. M. Halliday, Y. Nagai, P. H. Lee, N. Hattori, S-J. Lee
    • Journal Title

      Brain

      Volume: 142 Issue: 9 Pages: 2845-59

    • DOI

      10.1093/brain/awz205

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07823, KAKENHI-PROJECT-19K07987, KAKENHI-PROJECT-19K08003, KAKENHI-PROJECT-17K09811, KAKENHI-PROJECT-17K19658, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325

  • [Journal Article] 神経変性疾患に関わるリピート関連非ATG依存性翻訳と低複雑性ドメイン2019
    • Author(s)
      上山盛夫、永井義隆
    • Journal Title

      実験医学

      Volume: 37 Pages: 3070-3076

    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Journal Article] RNA結合タンパクと病態機序2019
    • Author(s)
      石川欽也、石黒太郎、佐藤望、永井義隆
    • Journal Title

      神経内科

      Volume: 91 Pages: 458-464

    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Journal Article] Parkinson’s disease is a type of amyloidosis featuring accumulation of amyloid fibrils of α-synuclein2019
    • Author(s)
      Araki Katsuya、Yagi Naoto、Aoyama Koki、Choong Chi-Jing、Hayakawa Hideki、Fujimura Harutoshi、Nagai Yoshitaka、Goto Yuji、Mochizuki Hideki
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 116 Issue: 36 Pages: 17963-17969

    • DOI

      10.1073/pnas.1906124116

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06352, KAKENHI-PROJECT-18H02741, KAKENHI-PROJECT-17K19658, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325

  • [Journal Article] RNA結合タンパクと病態機序2019
    • Author(s)
      石川欽也、石黒太郎、佐藤望、永井義隆
    • Journal Title

      神経内科

      Volume: 91 Pages: 458-464

    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Journal Article] Lipids as trans-acting effectors for α-synuclein in the pathogenesis of Parkinson’s disease2019
    • Author(s)
      Ikenaka K, Suzuki M, Mochizuki H, Nagai Y
    • Journal Title

      Frontiers in Neuroscience

      Volume: 13 Pages: 693-693

    • DOI

      10.3389/fnins.2019.00693

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07987, KAKENHI-PROJECT-17K19658, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325

  • [Journal Article] Structurally Distinct α‐Synuclein Fibrils Induce Robust Parkinsonian Pathology2019
    • Author(s)
      Hayakawa Hideki、Nakatani Rie、Ikenaka Kensuke、Aguirre Cesar、Choong Chi‐Jing、Tsuda Hiroshi、Nagano Seiichi、Koike Masato、Ikeuchi Takeshi、Hasegawa Masato、Papa Stella M.、Nagai Yoshitaka、Mochizuki Hideki、Baba Kousuke
    • Journal Title

      Movement Disorders

      Volume: 35 Issue: 2 Pages: 256-267

    • DOI

      10.1002/mds.27887

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09299, KAKENHI-PROJECT-18H02718, KAKENHI-PROJECT-18H02741, KAKENHI-PROJECT-16K09690, KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-17K19658, KAKENHI-PROJECT-16K19512, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325

  • [Journal Article] 神経変性疾患に関わるリピート関連非ATG依存性翻訳と低複雑性ドメイン2019
    • Author(s)
      上山盛夫、永井義隆
    • Journal Title

      実験医学

      Volume: 37 Pages: 3070-3076

    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Journal Article] 神経変性疾患に関わるリピート関連非ATG依存性翻訳と低複雑性ドメイン2019
    • Author(s)
      上山盛夫、永井義隆
    • Journal Title

      実験医学

      Volume: 37 Pages: 3070-3076

    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Journal Article] 脊髄小脳変性症に対するポリグルタミン蛋白質のミスフォールディング・凝集を標的とした分子治療2019
    • Author(s)
      永井義隆
    • Journal Title

      Clinical Neuroscience

      Volume: 37 Pages: 1015-1018

    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Journal Article] Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid.2019
    • Author(s)
      2. Kakuda K, Ikenaka K, Araki K, So M, Aguirre C, Kajiyama Y, Konaka K, Noi K, Baba K, Tsuda H, Nagano S, Ohmichi T, Nagai Y, Tokuda T, El-Agnaf O, Ogi H, Goto Y, Mochizuki H.
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 6001-6001

    • DOI

      10.1038/s41598-019-42399-0

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09690, KAKENHI-PROJECT-17K19658, KAKENHI-PROJECT-17K16122, KAKENHI-PLANNED-17H06352, KAKENHI-PROJECT-16K09716, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325, KAKENHI-PROJECT-18H02718, KAKENHI-PROJECT-18H02741

  • [Journal Article] Sleep Disturbance as a Potential Modifiable Risk Factor for Alzheimer’s Disease2019
    • Author(s)
      Minakawa Eiko、Wada Keiji、Nagai Yoshitaka
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 4 Pages: 803-803

    • DOI

      10.3390/ijms20040803

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19658, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325

  • [Journal Article] The lncRNA hsrω regulates arginine dimethylation of FUS to cause its proteasomal degradation in Drosophila.2019
    • Author(s)
      *Lo Piccolo L., Mochizuki H., *Nagai Y.
    • Journal Title

      J. Cell Sci.

      Volume: 132

    • DOI

      10.1242/jcs.236836

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19658, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325

  • [Journal Article] RNA結合タンパクと病態機序2019
    • Author(s)
      石川欽也、石黒太郎、佐藤望、永井義隆
    • Journal Title

      神経内科

      Volume: 91 Pages: 458-464

    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Journal Article] E46K mutantα-synuclein is more degradation resistant and exhibits greater toxic effects than wild-typeα-synuclein in Drosophila models of Parkinson's disease.2019
    • Author(s)
      R. Sakai, M. Suzuki, M. Ueyama, T. Takeuchi, E. N. Minakawa, H. Hayakawa, K. Baba, H. Mochizuki, Y. Nagai
    • Journal Title

      PLoS ONE

      Volume: 14 Issue: 6 Pages: e0218261-e0218261

    • DOI

      10.1371/journal.pone.0218261

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07823, KAKENHI-PROJECT-19K07987, KAKENHI-PROJECT-17K19658, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325

  • [Journal Article] 脊髄小脳変性症に対するポリグルタミン蛋白質のミスフォールディング・凝集を標的とした分子治療2019
    • Author(s)
      永井義隆
    • Journal Title

      Clinical Neuroscience

      Volume: 37 Pages: 1015-1018

    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Journal Article] 脊髄小脳変性症に対するポリグルタミン蛋白質のミスフォールディング・凝集を標的とした分子治療2019
    • Author(s)
      永井義隆
    • Journal Title

      Clinical Neuroscience

      Volume: 37 Pages: 1015-1018

    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Journal Article] NPM-hMLF1 fusion protein suppresses defects of a Drosophila FTLD model expressing the human FUS gene.2018
    • Author(s)
      Yamamoto I, Azuma Y, Kushimura Y, Yoshida H, Mizuta I, Mizuno T, Ueyama M, Nagai Y, Tokuda T, Yamaguchi M.
    • Journal Title

      Sci. Rep.

      Volume: 8 Issue: 1 Pages: 11291-11291

    • DOI

      10.1038/s41598-018-29716-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07385, KAKENHI-PROJECT-17K07500, KAKENHI-PROJECT-17K19658, KAKENHI-PROJECT-16K07346, KAKENHI-PROJECT-16K19519, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325, KAKENHI-PROJECT-15K09331

  • [Journal Article] Developing biomarkers for neurodegenerative diseases using genetically-modified common marmoset models2018
    • Author(s)
      Tomioka Ikuo、Nagai Yoshitaka、Seki Kazuhiko
    • Journal Title

      Neural Regeneration Research

      Volume: 13 Issue: 7 Pages: 1189-1189

    • DOI

      10.4103/1673-5374.235028

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19658, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325

  • [Journal Article] A spontaneously immortalized Schwann cell line from aldose reductase-deficient mice as a useful tool for studying polyol pathway and aldehyde metabolism.2018
    • Author(s)
      2.Niimi N, Yako H, Takaku S, Kato H, Matsumoto T, Nishito Y, Watabe K, Ogasawara S, Mizukami H, Yagihashi S, Chung SK, Sango K.
    • Journal Title

      Journal of Neurochemistry

      Volume: 印刷中 Pages: 97-106

    • DOI

      10.1016/j.neuint.2017.12.014

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07048, KAKENHI-PROJECT-17K19658, KAKENHI-PROJECT-17K16134, KAKENHI-PROJECT-16H05325, KAKENHI-PROJECT-15K19502

  • [Journal Article] Overexpression of ter94, Drosophila VCP, improved motor neuron degeneration induced by knockdown of TBPH, Drosophila TDP-43.2018
    • Author(s)
      Kushimura Y., Tokuda T., Azuma Y., Yamamoto I., Mizuta I., Mizuno T., Nakagawa M., Ueyama M., Nagai Y., Yoshida H., Yamaguchi M.
    • Journal Title

      Am. J. Neurodegener. Dis.

      Volume: 7 Pages: 11-31

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Journal Article] Parkinson’s disease-linked DNAJC13 mutation aggravates α-synuclein-induced neurotoxicity through perturbation of endosomal trafficking.2018
    • Author(s)
      Yoshida S, Hasegawa T, Suzuki M, Sugeno N, Kobayashi J, Ueyama M, Fukuda M, Ido-Fujibayashi A, Sekiguchi K, Ezura M, Kikuchi A, Baba T, Takeda A, Mochizuki H, Nagai Y and Aoki M.
    • Journal Title

      Hum Mol Genet.

      Volume: 27 Issue: 5 Pages: 823-836

    • DOI

      10.1093/hmg/ddy003

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09744, KAKENHI-PROJECT-17K09745, KAKENHI-PROJECT-17K19658, KAKENHI-PROJECT-17K16134, KAKENHI-PROJECT-16H05325, KAKENHI-PUBLICLY-17H05682, KAKENHI-PUBLICLY-17H05683, KAKENHI-PROJECT-26461303, KAKENHI-PROJECT-15K19502, KAKENHI-PROJECT-17K09789, KAKENHI-PROJECT-15K09331

  • [Journal Article] Supplemental Treatment for Huntington’s Disease with miR-132 that Is Deficient in Huntington’s Disease Brain2018
    • Author(s)
      Fukuoka Masashi、Takahashi Masaki、Fujita Hiromi、Chiyo Tomoko、Popiel H. Akiko、Watanabe Shoko、Furuya Hirokazu、Murata Miho、Wada Keiji、Okada Takashi、Nagai Yoshitaka、Hohjoh Hirohiko
    • Journal Title

      Mol. Ther. Nucleic Acids

      Volume: 11 Pages: 79-90

    • DOI

      10.1016/j.omtn.2018.01.007

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19658, KAKENHI-PROJECT-16K19003, KAKENHI-PROJECT-16K15093, KAKENHI-PROJECT-17K20087, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325

  • [Journal Article] Hippo, Drosophila MST, is a novel modifier of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS.2018
    • Author(s)
      Azuma Y, Tokuda T, Kushimura Y, Yamamoto I, Mizuta I, Mizuno T, Nakagawa M, Ueyama M, Nagai Y, Iwasaki Y, Yoshida M, Pan D, Yoshida H, Yamaguchi M.
    • Journal Title

      Exp Cell Res.

      Volume: 371 Issue: 2 Pages: 311-321

    • DOI

      10.1016/j.yexcr.2018.08.001

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07385, KAKENHI-PROJECT-17K07500, KAKENHI-PROJECT-17K19658, KAKENHI-PROJECT-16K07346, KAKENHI-PROJECT-16K19519, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325, KAKENHI-PROJECT-15K09331

  • [Journal Article] Overexpression of ter94, Drosophila VCP, improved motor neuron degeneration induced by knockdown of TBPH, Drosophila TDP-43.2018
    • Author(s)
      Kushimura Y., Tokuda T., Azuma Y., Yamamoto I., Mizuta I., Mizuno T., Nakagawa M., Ueyama M., Nagai Y., Yoshida H., Yamaguchi M.
    • Journal Title

      Am. J. Neurodegener. Dis.

      Volume: 1 Pages: 11-31

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Journal Article] Commentary: p62 plays a protective role in the autophagic degradation of polyglutamine protein oligomers in polyglutamine disease model flies.2017
    • Author(s)
      Saitoh Y., Nagai Y.
    • Journal Title

      J. Rare Dis. Res. & Treat.

      Volume: 2 Pages: 7-10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Journal Article] Chronic sleep fragmentation exacerbates amyloid β deposition in Alzheimer’s disease model mice2017
    • Author(s)
      Minakawa Eiko N.、Miyazaki Koyomi、Maruo Kazushi、Yagihara Hiroko、Fujita Hiromi、Wada Keiji、Nagai Yoshitaka
    • Journal Title

      Neurosci. Lett.

      Volume: 653 Pages: 362-369

    • DOI

      10.1016/j.neulet.2017.05.054

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19658, KAKENHI-PROJECT-16H05325, KAKENHI-PROJECT-15K07788

  • [Journal Article] FUS toxicity is rescued by the modulation of lncRNA hsrω expression in Drosophila melanogaster.2017
    • Author(s)
      Piccolo, L. L., Jantrapirom, S., Nagai, Y. and Yamaguchi M.
    • Journal Title

      Sci. Rep.

      Volume: 7(1) Issue: 1 Pages: 15660-15660

    • DOI

      10.1038/s41598-017-15944-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07500, KAKENHI-PROJECT-17K19658, KAKENHI-PROJECT-16H05325, KAKENHI-PROJECT-15F15789, KAKENHI-PROJECT-26440188

  • [Journal Article] 良好な睡眠を通じた認知症の発症・進展予防の可能性2017
    • Author(s)
      皆川栄子、和田圭司、永井義隆
    • Journal Title

      実験医学

      Volume: 35 Pages: 2091-2094

    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Journal Article] Commentary: p62 plays a protective role in the autophagic degradation of polyglutamine protein oligomers in polyglutamine disease model flies.2017
    • Author(s)
      Saitoh Y., Nagai Y.
    • Journal Title

      J. Rare Dis. Res. & Treat.

      Volume: 2 Pages: 7-10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Journal Article] 良好な睡眠を通じた認知症の発症・進展予防の可能性2017
    • Author(s)
      皆川栄子、和田圭司、永井義隆
    • Journal Title

      実験医学 増刊号「認知症－発症前治療のために解明すべき分子病態は何か？」

      Volume: 35 Pages: 2091-2094

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Journal Article] Generation of transgenic marmosets using a tetracyclin-inducible transgene expression system as a neurodegenerative disease model†2017
    • Author(s)
      Tomioka Ikuo、Nogami Naotake、Nakatani Terumi、Owari Kensuke、Fujita Naoko、Motohashi Hideyuki、Takayama Osamu、Takae Kentaro、Nagai Yoshitaka、Seki Kazuhiko
    • Journal Title

      Biol. Reprod.

      Volume: 97 Issue: 5 Pages: 772-780

    • DOI

      10.1093/biolre/iox129

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19658, KAKENHI-PROJECT-16H05325

  • [Journal Article] ショウジョウバエを用いたパーキンソン病の病態解析2017
    • Author(s)
      堺竜介、鈴木マリ、永井義隆
    • Journal Title

      医学のあゆみ

      Volume: 262 Pages: 641-646

    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Journal Article] Transgenic monkey model of the polyglutamine diseases recapitulating progressive neurological symptoms.2017
    • Author(s)
      Tomioka I, Ishibashi H, Minakawa EN, Motohashi HH, Takayama O, Saito Y, Popiel HA, Puentes S, Owari K, Nakatani T, Nogami N, Yamamoto K, Noguchi S, Yonekawa T, Tanaka Y, Fujita N, Suzuki H, Kikuchi H, Aizawa S, Nagano S, Yamada D, Nishino I, Ichinohe N, Wada K, Kohsaka S, Nagai Y, Seki K.
    • Journal Title

      eNeuro

      Volume: 4 Issue: 2 Pages: 0250-56

    • DOI

      10.1523/eneuro.0250-16.2017

    • NAID

      120007100051

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09690, KAKENHI-PROJECT-16K09734, KAKENHI-PROJECT-16H05325, KAKENHI-PROJECT-26870884, KAKENHI-PLANNED-25117009, KAKENHI-PROJECT-16H06277

  • [Journal Article] Protein Misfolding and Aggregation as a Therapeutic Target for Polyglutamine Diseases2017
    • Author(s)
      Takeuchi Toshihide、Nagai Yoshitaka
    • Journal Title

      Brain Sci.

      Volume: 7 Issue: 12 Pages: 128-128

    • DOI

      10.3390/brainsci7100128

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19658, KAKENHI-PROJECT-16H05325, KAKENHI-PROJECT-26713030

  • [Journal Article] ショウジョウバエを用いたパーキンソン病の病態解析2017
    • Author(s)
      堺竜介、鈴木マリ、永井義隆
    • Journal Title

      医学のあゆみ 増刊号「パーキンソン病の新展開－発症の分子機構と新規治療」

      Volume: 262 Pages: 641-646

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Journal Article] Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA312017
    • Author(s)
      Taro Ishiguro, Nozomu Sato, Morio Ueyama, Nobuhiro Fujikake, Chantal Sellier, Akemi Kanegami, Eiichi Tokuda, Bita Zamiri, Terence Gall-Duncan, Mila Mirceta, Yoshiaki Furukawa, 他８名
    • Journal Title

      Neuron

      Volume: 94 Issue: 1 Pages: 108-124

    • DOI

      10.1016/j.neuron.2017.02.046

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01566, KAKENHI-PROJECT-15H06181, KAKENHI-PROJECT-15H06588, KAKENHI-PROJECT-17K15077, KAKENHI-PROJECT-16H05325, KAKENHI-PROJECT-15K09331

  • [Journal Article] エクソソームによる生体内のタンパク質恒常性の維持2016
    • Author(s)
      武内敏秀、永井義隆
    • Journal Title

      細胞

      Volume: 48 Pages: 5-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Journal Article] パーキンソン病における脂質の役割2016
    • Author(s)
      永井義隆
    • Journal Title

      脳２１

      Volume: 19 Pages: 346-352

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Journal Article] ショウジョウバエを用いた神経疾患研究2016
    • Author(s)
      鈴木マリ、永井義隆
    • Journal Title

      生体の科学

      Volume: 67 Pages: 589-595

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Journal Article] エクソソームを介したプロテオスターシス維持機構と神経変性疾患2016
    • Author(s)
      武内敏秀、永井義隆
    • Journal Title

      Dementia Japan

      Volume: 30 Pages: 368-376

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Journal Article] Generation of a novel transgenic rat model for tracing extracellular vesicles in body fluids.2016
    • Author(s)
      Yoshimura A, Kawamata M, Yoshioka Y, Katsuda T, Kikuchi H, Nagai Y, Adachi N, Numakawa T, Kunugi H, Ochiya T, Tamai Y.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 31172-31172

    • DOI

      10.1038/srep31172

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K06996, KAKENHI-PROJECT-16H05325

  • [Journal Article] パ－キンソン病の動物モデル－最近の話題2016
    • Author(s)
      高橋良輔、佐藤栄人、永井義隆、松井秀彰、望月秀
    • Journal Title

      Frontiers in Parkinson Disease

      Volume: 9 Pages: 5-13

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Journal Article] A small-angle X-ray scattering study of alpha-synuclein from human red blood cells.2016
    • Author(s)
      Araki K, Yagi N, Nakatani R, Sekiguchi H, So M, Yagi H, Ohta N, Nagai Y, Goto Y, Mochizuki H.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 30473-30473

    • DOI

      10.1038/srep30473

    • NAID

      120006557626

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PUBLICLY-15H01558, KAKENHI-ORGANIZER-26105001, KAKENHI-PROJECT-26293210, KAKENHI-PROJECT-16K09716, KAKENHI-INTERNATIONAL-15K21719, KAKENHI-PROJECT-16H05325

  • [Journal Article] パ－キンソン病の動物モデル－最近の話題2016
    • Author(s)
      高橋良輔、佐藤栄人、永井義隆、松井秀彰、望月秀樹
    • Journal Title

      Frontiers in Parkinson Disease

      Volume: 9 Pages: 5-13

    • Data Source
      KAKENHI-PROJECT-26670446

  • [Journal Article] Molecular Basis of Orb2 Amyloidogenesis and Blockade of Memory Consolidation2016
    • Author(s)
      Hervas R, Li L, Majumdar A, Fernandez-Ramirez Mdel C, Unruh JR, Slaughter BD, Galera-Prat A, Santana E, Suzuki M, Nagai Y, Bruix M, Casas-Tinto S, Menendez M, Laurents DV, Si K, Carrio-Vazquez M.
    • Journal Title

      PLoS Biol

      Volume: 26 Issue: 1 Pages: e1002361-e1002361

    • DOI

      10.1371/journal.pbio.1002361

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19502, KAKENHI-PROJECT-26670446

  • [Journal Article] エクソソームによる生体内のタンパク質恒常性の維持2016
    • Author(s)
      武内敏秀、永井義隆
    • Journal Title

      細胞

      Volume: 48 Pages: 5-8

    • Data Source
      KAKENHI-PROJECT-26670446

  • [Journal Article] パーキンソン病の基礎と臨床の最先端2016
    • Author(s)
      望月秀樹、永井義隆
    • Journal Title

      脳２１

      Volume: 19 Pages: 322-323

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Journal Article] 神経変性機序と治療展望2016
    • Author(s)
      永井義隆、田港朝也
    • Journal Title

      Mebio

      Volume: 33 Pages: 62-70

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Journal Article] Normalization of overexpressed alpha-synuclein causing Parkinson's disease by a moderate gene silencing with RNA interference2015
    • Author(s)
      Takahashi M, Suzuki M, Fukuoka M, Fujikake N, Watanabe S, Murata M, Wada K, Nagai Y, Hohjoh H
    • Journal Title

      Mol Ther Nucleic Acids

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Journal Article] Normalization of overexpressed alpha-synuclein causing Parkinson's disease by a moderate gene silencing with RNA interference2015
    • Author(s)
      Takahashi M, Suzuki M, Fukuoka M, Fujikake N, Watanabe S, Murata M, Wada K, Nagai Y, Hohjoh H
    • Journal Title

      Mol Ther Nucleic Acids

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-25110741

  • [Journal Article] p62 plays a protective role in the autophagic degradation of polyglutamine protein oligomers in polyglutamine disease model flies.2015
    • Author(s)
      Saitoh Y, Fujikake N, Okamoto Y, Popiel HA, Hatanaka Y, Ueyama M, Suzuki M, Gaumer S, Murata M, Wada K, Nagai Y.
    • Journal Title

      J Biol Chem

      Volume: 290 Issue: 3 Pages: 1442-53

    • DOI

      10.1074/jbc.m114.590281

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24591286, KAKENHI-PROJECT-24591287, KAKENHI-PUBLICLY-25110741, KAKENHI-PROJECT-25860733, KAKENHI-PROJECT-26670446, KAKENHI-PROJECT-15K09331

  • [Journal Article] その他のFTLD―異常蛋白の視点から2015
    • Author(s)
      上山盛夫、藤掛伸宏、永井義隆
    • Journal Title

      Clinical Neuroscience

      Volume: 33 Pages: 312-314

    • Data Source
      KAKENHI-PUBLICLY-25110741

  • [Journal Article] Normalization of overexpressed alpha-synuclein causing Parkinson’s disease by a moderate gene silencing with RNA interference.2015
    • Author(s)
      Takahashi M., Suzuki M., Fukuoka M., Fujikake N., Watanabe S., Murata M., Wada K., Nagai Y., and *Hohjoh H.
    • Journal Title

      Mol Ther Nucleic Acids

      Volume: 4 Pages: e241-e241

    • DOI

      10.1038/mtna.2015.14

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390226, KAKENHI-PROJECT-15K19502, KAKENHI-PROJECT-25670428, KAKENHI-PROJECT-26670446, KAKENHI-PROJECT-25871169

  • [Journal Article] Abnormalities in synaptic dynamics during development in a mouse model of spinocerebellar ataxia type 1.2015
    • Author(s)
      Hatanaka Y., Watase K., Wada K., Nagai Y.
    • Journal Title

      Sci. Rep.

      Volume: 5 Issue: 1 Pages: 16102-16102

    • DOI

      10.1038/srep16102

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26670446, KAKENHI-PROJECT-25282241

  • [Journal Article] Intercellular chaperone transmission via exosomes contributes to maintenance of protein homeostasis at the organismal level.2015
    • Author(s)
      Takeuchi T, Suzuki M, Fujikake N, Popiel HA, Kikuchi H, Futaki S, Wada K, Nagai Y
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: in press Issue: 19

    • DOI

      10.1073/pnas.1412651112

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-25110741, KAKENHI-PROJECT-15K19502, KAKENHI-PROJECT-24591287, KAKENHI-PROJECT-26670446, KAKENHI-PROJECT-26713030

  • [Journal Article] その他のFTLD―異常蛋白の視点から2015
    • Author(s)
      上山盛夫、藤掛伸宏、永井義隆
    • Journal Title

      Clinical Neuroscience

      Volume: 33 Pages: 312-314

    • Data Source
      KAKENHI-PROJECT-26670446

  • [Journal Article] Synchrotron FTIR Micro-Spectroscopy for Structural Analysis of Lewy Bodies in the Brain of Parkinson’s Disease Patients2015
    • Author(s)
      K. Araki, N. Yagi, Y. Ikemoto, S. Choong, H. Hayakawa, G. Beck, H. Sumi, H. Fujimura, T. Moriwaki, Y. Nagai, Y. Goto and H. Mochizuki
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 17625-17625

    • DOI

      10.1038/srep17625

    • NAID

      120006557628

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K05142, KAKENHI-PUBLICLY-15H01558, KAKENHI-PROJECT-15H04362, KAKENHI-PROJECT-15K14339, KAKENHI-PROJECT-26670446, KAKENHI-PROJECT-26293210

  • [Journal Article] Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease.2015
    • Author(s)
      Suzuki M, Fujikake N, Takeuchi T, Kohyama-Koganeya A, Nakajima K, Hirabayashi Y, Wada K, Nagai Y.
    • Journal Title

      Hum Mol Genet. 2015 Dec 1;24(23):6675-86

      Volume: 24 Issue: 23 Pages: 6675-6686

    • DOI

      10.1093/hmg/ddv372

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K19016, KAKENHI-PROJECT-15K19502, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-26670446, KAKENHI-PROJECT-26713030

  • [Journal Article] Peptide-based therapeutic approaches for treatment of the polyglutamine diseases2014
    • Author(s)
      Takeuchi T., Popiel H.A., Futaki S., Wada K., Nagai Y
    • Journal Title

      Curr. Med. Chem

      Volume: (in press) Issue: 23 Pages: 2575-2582

    • DOI

      10.2174/0929867321666140217124038

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390237, KAKENHI-PROJECT-24659438, KAKENHI-PUBLICLY-25110741, KAKENHI-PROJECT-26670446, KAKENHI-PROJECT-26713030

  • [Journal Article] ポリグルタミン病における神経変性2014
    • Author(s)
      永井義隆
    • Journal Title

      BRAIN MEDICAL

      Volume: 26 Pages: 225-229

    • Data Source
      KAKENHI-PUBLICLY-25110741

  • [Journal Article] ポリグルタミン病における神経変性2014
    • Author(s)
      永井義隆
    • Journal Title

      BRAIN MEDICAL

      Volume: 26 Pages: 225-229

    • Data Source
      KAKENHI-PROJECT-26670446

  • [Journal Article] Identification of ter94, Drosophila VCP, as a strong modulator of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS2014
    • Author(s)
      Azuma Y., Tokuda T., Shimamura M., Kyotani A., Sasayama H., Yoshida T., Mizuta I., Mizuno T., Nakagawa M., Fujikake N., Ueyama M., Nagai Y., Yamaguchi M
    • Journal Title

      Hum. Mol. Genet

      Volume: 23(13) Issue: 13 Pages: 3467-3480

    • DOI

      10.1093/hmg/ddu055

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390237, KAKENHI-PROJECT-24570211, KAKENHI-PROJECT-24591286, KAKENHI-PROJECT-24659438, KAKENHI-PUBLICLY-25110741, KAKENHI-PROJECT-25860733, KAKENHI-PROJECT-26670446

  • [Journal Article] VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease.2014
    • Author(s)
      Miura E, Hasegawa T, Konno M, Suzuki M, Sugeno N, Fujikake N, Geisler S, Tabuchi M, Oshima R, Kikuchi A, Baba T, Wada K, Nagai Y, Takeda A, Aoki M.
    • Journal Title

      Neurobio Dis

      Volume: 71 Pages: 1-13

    • DOI

      10.1016/j.nbd.2014.07.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591266, KAKENHI-PROJECT-24390219, KAKENHI-PROJECT-24591286, KAKENHI-PUBLICLY-25110741, KAKENHI-PROJECT-26461263, KAKENHI-PROJECT-26461303, KAKENHI-PROJECT-26670446

  • [Journal Article] 認知症におけるシナプス病態2013
    • Author(s)
      畑中悠佑、和田圭司、永井義隆
    • Journal Title

      Dementia Japan

      Volume: 27 (2) Pages: 128-135

    • Data Source
      KAKENHI-PROJECT-24659438

  • [Journal Article] 認知症におけるシナプス病態2013
    • Author(s)
      畑中悠佑、和田圭司、永井義隆
    • Journal Title

      Dementia Japan

      Volume: 印刷中

    • Data Source
      KAKENHI-PROJECT-23390237

  • [Journal Article] 認知症におけるシナプス病態2013
    • Author(s)
      畑中悠佑、和田圭司、永井義隆
    • Journal Title

      Dementia Japan

      Volume: 印刷中

    • Data Source
      KAKENHI-PUBLICLY-23110528

  • [Journal Article] 認知症におけるシナプス病態2013
    • Author(s)
      畑中悠祐、和田圭司、永井義隆
    • Journal Title

      Dementia Japan

      Volume: 27 (2) Pages: 128-135

    • Data Source
      KAKENHI-PUBLICLY-25110741

  • [Journal Article] コンフォメーション病としての神経変性疾患2013
    • Author(s)
      永井義隆、藤掛伸宏
    • Journal Title

      ファルマシア

      Volume: 49 (9) Pages: 849-853

    • NAID

      110009995811

    • Data Source
      KAKENHI-PROJECT-24659438

  • [Journal Article] TDP-43 associates with stalled ribosomes and contributes to cell survival during cellular stress2013
    • Author(s)
      Higashi S., Kabuta T., Nagai Y., Tsuchiya Y., Akiyama H., Wada K
    • Journal Title

      J. Neurochem

      Volume: 126(2) Issue: 2 Pages: 288-300

    • DOI

      10.1111/jnc.12194

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390237, KAKENHI-PROJECT-23791008, KAKENHI-PROJECT-24659438, KAKENHI-PROJECT-24680038, KAKENHI-PUBLICLY-25110741, KAKENHI-PUBLICLY-23110527

  • [Journal Article] Inhibition of protein misfolding/aggregation using polyglutamine binding peptide QBP1 as a therapy for the polyglutamine diseases2013
    • Author(s)
      Popiel HA, Takeuchi T, Burke JR, Strittmatter WJ, Toda T, Wada K, Nagai Y
    • Journal Title

      Neurotherapeutics

      Volume: (in press)

    • URL

      http://link.springer.com/article/10.1007%2Fs13311-013-0184-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21200072

  • [Journal Article] コンフォメーション病としての神経変性疾患2013
    • Author(s)
      永井義隆、藤掛伸宏
    • Journal Title

      ファルマシア

      Volume: 49 (9) Pages: 849-853

    • NAID

      110009995811

    • Data Source
      KAKENHI-PUBLICLY-25110741

  • [Journal Article] 認知症におけるシナプス病態2013
    • Author(s)
      畑中悠佑, 和田圭司, 永井義隆
    • Journal Title

      Dementia Japan

      Volume: 27 (2) Pages: 128-135

    • Data Source
      KAKENHI-PROJECT-23390237

  • [Journal Article] Inhibition of Protein Misfolding/Aggregation Using Polyglutamine Binding Peptide QBP1 as a Therapy for the Polyglutamine Diseases.2013
    • Author(s)
      H. Akiko Popiel
    • Journal Title

      Neuro therapeutics

      Volume: (印刷中) Issue: 3 Pages: 440-446

    • DOI

      10.1007/s13311-013-0184-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J08829, KAKENHI-PLANNED-22129006, KAKENHI-PROJECT-23249049, KAKENHI-PROJECT-23390237, KAKENHI-PROJECT-24591287, KAKENHI-PROJECT-24659438, KAKENHI-PUBLICLY-25110741, KAKENHI-PROJECT-25882021, KAKENHI-PUBLICLY-23110528

  • [Journal Article] Na+/H+ exchangers induce autophagy in neurons and inhibit polyglutamine-induced aggregate formation2013
    • Author(s)
      Togashi K., Wakatsuki S., Furuno A., Tokunaga S., Nagai Y., Araki T
    • Journal Title

      PLoS One

      Volume: 8(11) Issue: 11 Pages: e81313-e81313

    • DOI

      10.1371/journal.pone.0081313

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390237, KAKENHI-PUBLICLY-24111559, KAKENHI-PROJECT-24500398, KAKENHI-PROJECT-24659438, KAKENHI-PUBLICLY-25110741

  • [Journal Article] コンフォメーション病としての神経変性疾患2013
    • Author(s)
      永井義隆, 藤掛伸宏
    • Journal Title

      ファルマシア

      Volume: 49 (9) Pages: 849-853

    • NAID

      110009995811

    • Data Source
      KAKENHI-PROJECT-23390237

  • [Journal Article] ショウジョウバエなど小動物を用いた筋萎縮性側索硬化症モデル2012
    • Author(s)
      藤掛伸宏、長野清一、永井義隆
    • Journal Title

      神経内科

      Volume: 76 (3) Pages: 266-274

    • Data Source
      KAKENHI-PROJECT-24659438

  • [Journal Article] 神経変性疾患病態研究のキーワード2012
    • Author(s)
      永井義隆
    • Journal Title

      臨床神経学

      Volume: 52 Pages: 874-876

    • NAID

      130004505190

    • Data Source
      KAKENHI-PUBLICLY-23110528

  • [Journal Article] Hsp40 Gene Therapy Exerts Therapeutic Effects on Polyglutamine Disease Micevia a Non-Cell Autonomous Mechanism.2012
    • Author(s)
      H. Akiko Popiel
    • Journal Title

      PLoS One

      Volume: 7 Issue: 11 Pages: e51069-e51069

    • DOI

      10.1371/journal.pone.0051069

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J08829, KAKENHI-PROJECT-21200072, KAKENHI-PLANNED-22129006, KAKENHI-PROJECT-23249049, KAKENHI-PROJECT-23390237, KAKENHI-PROJECT-23590473, KAKENHI-PROJECT-24591287, KAKENHI-PROJECT-24659438, KAKENHI-PUBLICLY-23110515, KAKENHI-PUBLICLY-23110528

  • [Journal Article] 神経変性疾患病態研究のキーワード2012
    • Author(s)
      永井義隆
    • Journal Title

      臨床神経学

      Volume: 52 (11) Pages: 874-876

    • NAID

      130004505190

    • Data Source
      KAKENHI-PROJECT-24659438

  • [Journal Article] ショウジョウバエなど小動物を用いた筋萎縮性側索硬化症モデル2012
    • Author(s)
      藤掛伸宏、長野清一、永井義隆
    • Journal Title

      神経内科

      Volume: 76(3) Pages: 266-274

    • URL

      http://www.kahyo.com/item/S201203-763

    • Data Source
      KAKENHI-PROJECT-22659172

  • [Journal Article] ショウジョウバエなど小動物を用いた筋萎縮性側索硬化症モデル2012
    • Author(s)
      藤掛伸宏, 長野清一, 永井義隆
    • Journal Title

      神経内科

      Volume: 76 (3) Pages: 266-274

    • Data Source
      KAKENHI-PROJECT-23390237

  • [Journal Article] 神経変性疾患病態研究のキーワード2012
    • Author(s)
      永井義隆
    • Journal Title

      臨床神経学

      Volume: 52 (11) Pages: 874-876

    • NAID

      130004505190

    • Data Source
      KAKENHI-PROJECT-23390237

  • [Journal Article] ショウジョウバエなど小動物を用いた筋萎縮性側索硬化症モデル2012
    • Author(s)
      藤掛伸宏, 長野清一, 永井義隆
    • Journal Title

      神経内科

      Volume: 76 Pages: 266-274

    • Data Source
      KAKENHI-PROJECT-22590932

  • [Journal Article] Calcium leak through ryanodine receptor is involved in neuronal death induced by mutant huntingtin2012
    • Author(s)
      Suzuki M., Nagai Y., Wada K., Koike T
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 429(1-2) Issue: 1-2 Pages: 18-23

    • DOI

      10.1016/j.bbrc.2012.10.107

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390237, KAKENHI-PROJECT-24659438, KAKENHI-PUBLICLY-23110528

  • [Journal Article] Knockdown of the Drosophila Fused in Sarcoma (FUS) homologue causes deficient locomotive behavior and shortening of motoneuron terminal branches.2012
    • Author(s)
      Sasayama, H., Shimamura, M., Tokuda, T., Azuma, Y., Yoshida, T., Mizuno, T., Nakagawa, M., Fujikake, N., Nagai, Y. and Yamaguchi, M
    • Journal Title

      PLoS ONE

      Volume: 7(6), Issue: 6 Pages: e39483-e39483

    • DOI

      10.1371/journal.pone.0039483

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22241052, KAKENHI-PUBLICLY-23013015, KAKENHI-PROJECT-23390237, KAKENHI-PROJECT-23570004, KAKENHI-PROJECT-23591252, KAKENHI-PROJECT-24406030, KAKENHI-PROJECT-24570211, KAKENHI-PROJECT-24591286, KAKENHI-PROJECT-24659438, KAKENHI-PUBLICLY-23110528

  • [Journal Article] QBP1を応用した異常伸長ポリグルタミン蛋白質の特異的分解2011
    • Author(s)
      永井義隆
    • Journal Title

      臨床神経学

      Volume: 51 Pages: 1108-1110

    • Data Source
      KAKENHI-PROJECT-23390237

  • [Journal Article] α-Synuclein transgenic Drosophila as a model of Parkinson's Disease and related synucleinopathies2011
    • Author(s)
      Mizuno H, Fujikake N, Wada K, Nagai Y
    • Journal Title

      Parkinsons Dis

      Volume: 2011 Pages: 212706-212706

    • DOI

      10.4061/2011/212706

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659172, KAKENHI-PROJECT-22790839

  • [Journal Article] ショウジョウバエモデルから解明されたTDP-43プロテイノパチーの分子病態2011
    • Author(s)
      永井義隆
    • Journal Title

      Dementia Japan

      Volume: 25 Pages: 129-136

    • Data Source
      KAKENHI-PUBLICLY-23110528

  • [Journal Article] ショウジョウバエモデルから解明されたTDP-43プロテイノパチーの分子病態2011
    • Author(s)
      永井義隆, 藤掛伸宏
    • Journal Title

      Dementia Japan

      Volume: 25 (2) Pages: 129-136

    • Data Source
      KAKENHI-PROJECT-23390237

  • [Journal Article] Parkinson's disease-associated mutations in alpha-synuclein and UCH-L1 inhibit the unconventional secretion of UCH-L12011
    • Author(s)
      Konya, C.
    • Journal Title

      Neurochem Int

      Volume: 59 Issue: 2 Pages: 251-258

    • DOI

      10.1016/j.neuint.2011.05.012

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-22020038, KAKENHI-PROJECT-22560454, KAKENHI-PROJECT-22659172, KAKENHI-PROJECT-22790838, KAKENHI-PUBLICLY-23110528, KAKENHI-PROJECT-23390237, KAKENHI-PROJECT-23650199

  • [Journal Article] α-Synuclein transgenic Drosophila as a model of Parkinson's Disease and related synucleinopathies2011
    • Author(s)
      Mizuno H, Fujikake N, Wada K, Nagai Y
    • Journal Title

      Parkinsons Dis 2011

      Pages: 212706-212706

    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] ショウジョウバエモデルから解明されたTDP-43プロテイノパチーの分子病態2011
    • Author(s)
      永井義隆
    • Journal Title

      Dementia Japan

      Volume: 25 Pages: 129-136

    • Data Source
      KAKENHI-PUBLICLY-22020038

  • [Journal Article] Genetic and clinical analysis in a Chinese parkinsonism-predominant spinocerebellar ataxia type 2 family2011
    • Author(s)
      Sun H, Satake W, Zhang C, Nagai Y, Tian Y, Fu S, Yu J, Qian Y, Qian Y, Chu J, Toda T
    • Journal Title

      J Hum Genet 56(4)

      Pages: 330-334

    • NAID

      10030659058

    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] QBP1を応用した異常伸長ポリグルタミン蛋白質の特異的分解2011
    • Author(s)
      永井義隆
    • Journal Title

      臨床神経学

      Volume: 51 Pages: 1108-1110

    • Data Source
      KAKENHI-PUBLICLY-23110528

  • [Journal Article] ショウジョウバエモデルから解明されたTDP-43プロテイノパチーの分子病態2011
    • Author(s)
      永井義隆
    • Journal Title

      Dementia Japan

      Volume: 25 Pages: 129-136

    • Data Source
      KAKENHI-PROJECT-22659172

  • [Journal Article] ショウジョウバエモデルから解明されたTDP-43プロテイノパチーの分子病態2011
    • Author(s)
      永井義隆
    • Journal Title

      Dementia Japan

      Volume: 25 Pages: 129-136

    • Data Source
      KAKENHI-PROJECT-23390237

  • [Journal Article] The aggregation inhibitor peptide QBP1 as a therapeutic molecule for the polyglutamine neurodegenerative diseases2011
    • Author(s)
      H.Akiko Popiel
    • Journal Title

      Journal of Atnino Acids

      Volume: 2011 Pages: 265084-265084

    • DOI

      10.4061/2011/265084

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J08829, KAKENHI-PROJECT-21200072, KAKENHI-PUBLICLY-22020038, KAKENHI-PLANNED-22129006, KAKENHI-PROJECT-22659172, KAKENHI-PROJECT-22790837, KAKENHI-PUBLICLY-23110528, KAKENHI-PROJECT-23249049, KAKENHI-PROJECT-23390237

  • [Journal Article] Genetic and clinical analysis in a Chinese parkinsonism-predominant spinocerebellar ataxia type 2 family2011
    • Author(s)
      Sun, H.
    • Journal Title

      J Hum Genet

      Volume: 56 Issue: 4 Pages: 330-334

    • DOI

      10.1038/jhg.2011.14

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-22020038, KAKENHI-PLANNED-22129006, KAKENHI-PROJECT-22659172, KAKENHI-PUBLICLY-23110528, KAKENHI-PROJECT-23249049, KAKENHI-PROJECT-23390237

  • [Journal Article] QBP1を応用した異常伸長ポリグルタミン蛋白質の特異的分解2011
    • Author(s)
      永井義隆
    • Journal Title

      臨床神経学

      Volume: 51 Pages: 1108-1110

    • Data Source
      KAKENHI-PUBLICLY-22020038

  • [Journal Article] QBP1を応用した異常伸長ポリグルタミン蛋白質の特異的分解2011
    • Author(s)
      永井義隆
    • Journal Title

      臨床神経学

      Volume: 51 Pages: 1108-1110

    • Data Source
      KAKENHI-PROJECT-22659172

  • [Journal Article] QBP1を応用した異常伸長ポリグルタミン蛋白質の特異的分解2011
    • Author(s)
      永井義隆, 貫名信行
    • Journal Title

      臨床神経学

      Volume: 51 (11) Pages: 1108-1110

    • Data Source
      KAKENHI-PROJECT-23390237

  • [Journal Article] ショウジョウバエモデルから解明されたTDP-43プロテイノパチーの分子病態2011
    • Author(s)
      永井義隆、藤掛伸宏
    • Journal Title

      Dementia Japan

      Volume: 25(2) Pages: 129-136

    • URL

      http://www.sasappa.co.jp/online/abstract/jsdr/1/25/html/101250206.html

    • Data Source
      KAKENHI-PROJECT-22659172

  • [Journal Article] QBP1を応用した異常伸長ポリグルタミン蛋白質の特異的分解2011
    • Author(s)
      永井義隆、貫名信行
    • Journal Title

      臨床神経学

      Volume: 51(11) Pages: 1108-1110

    • URL

      http://www.neurology-jp.org/Journal/index_j.html

    • Data Source
      KAKENHI-PROJECT-22659172

  • [Journal Article] Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein.2010
    • Author(s)
      Bauer PO, Goswami A, Wong HK, Okuno M, Kurosawa M, Yamada M, Miyazaki H, Matsumoto G, Kino Y, Nagai Y, Nukina N
    • Journal Title

      Nature Biotechnology 28

      Pages: 256-63

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20023019

  • [Journal Article] TDP-43プロテイノパチーの動物モデル2010
    • Author(s)
      永井義隆
    • Journal Title

      最新医学

      Volume: 65(7) Pages: 1603-1613

    • URL

      http://www.saishin-igaku.co.jp/backnum/2010/y6507.html

    • Data Source
      KAKENHI-PROJECT-22659172

  • [Journal Article] 脊髄小脳変性症2010
    • Author(s)
      永井義隆
    • Journal Title

      ドクターサロン

      Volume: 54 Pages: 729-732

    • Data Source
      KAKENHI-PUBLICLY-21025042

  • [Journal Article] Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein.2010
    • Author(s)
      Bauer PO, Goswami A, Wong HK, Okuno M, Kurosawa M, Yamada M, Miyazaki H, Matsumoto G, Kino Y, Nagai Y, Nukina N
    • Journal Title

      Nature Biotechnology 28

      Pages: 256-63

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-21025042

  • [Journal Article] TDP-43プロテイノパチーの動物モデル2010
    • Author(s)
      永井義隆、藤掛伸宏
    • Journal Title

      最新医学

      Volume: 65 Pages: 1603-1613

    • Data Source
      KAKENHI-PROJECT-22659172

  • [Journal Article] Genetic testing for Huntington's disease in Parkinsonism2010
    • Author(s)
      Rahman MS, Nagai Y, Popiel HA, Fujikake N, Okamoto Y, Ahmed MU, Islam MA, Islam MT, Ahmed S, Rahman KM, Uddin MJ, Dey SK, Ahmed Q, Hossain MA, Jahan N, Toda T
    • Journal Title

      Mymensingh Med J

      Volume: 19 Pages: 510-514

    • URL

      http://www.banglajol.info/index.php/MMJ/article/view/6708

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21200072

  • [Journal Article] Induction of molecular chaperones as a therapeutic strategy for the polyglutamine diseases2010
    • Author(s)
      Nagai Y, Fujikake N, Popiel HA, Wada K
    • Journal Title

      Curr Pharm Biotechnol 11(2)

      Pages: 188-197

    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] 脊髄小脳変性症2010
    • Author(s)
      永井義隆
    • Journal Title

      ドクターサロン

      Volume: 54 Pages: 729-732

    • Data Source
      KAKENHI-PUBLICLY-22020038

  • [Journal Article] TDP-43プロテイノパチーの動物モデル2010
    • Author(s)
      永井義隆、藤掛伸宏
    • Journal Title

      最新医学

      Volume: 65 Pages: 1603-1613

    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] Induction of molecular chaperones as a therapeutic strategy for the polyglutamine diseases.2010
    • Author(s)
      Nagai Y, Fujikake N, Popiel HA, Wada K
    • Journal Title

      Current Pharmaceutical Biotechnology 11

      Pages: 188-97

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20023019

  • [Journal Article] Genetic Testing for Huntington's Disease in Parkinsonism2010
    • Author(s)
      Rahman MS, Nagai Y, Popiel HA, Fujikake N, Okamoto Y, Ahmed MU, Islam MA, Islam MT, Ahmed S, Rahman KM, Uddin MJ, Dey SK, Ahmed Q, Hossain MA, Jahan N, Toda T
    • Journal Title

      Mymensingh Med J 19(4)

      Pages: 510-514

    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] Novel gene therapy for polyglutamine diseases to degrade selectively the pathogenic protein2010
    • Author(s)
      Bauer PO, Goswami A, Wong HK, Okuno M, Kurosawa M, Yamada M, Miyazaki H, Matsumoto G, Kino Y, Nagai Y, Nukina N
    • Journal Title

      Nat Biotechnol 28(3)

      Pages: 256-263

    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein2010
    • Author(s)
      Bauer PO, Goswami A, Wong HK, Okuno M, Kurosawa M, Yamada M, Miyazaki H, Matsumoto G, Kino Y, Nagai Y, Nukina N
    • Journal Title

      Nature Biotechnology 28

      Pages: 256-63

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] Induction of molecular chaperones as a therapeutic strategy for the polyglutamine diseases.2010
    • Author(s)
      Nagai Y, Fujikake N, Popiel HA, Wada K
    • Journal Title

      Current Pharmaceutical Biotechnology 11

      Pages: 188-97

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20056021

  • [Journal Article] Induction of molecular chaperones as a therapeutic strategy for the polyglutamine diseases.2010
    • Author(s)
      Nagai Y, Fujikake N, Popiel HA, Wada K
    • Journal Title

      Current Pharmaceutical Biotechnology 11

      Pages: 188-197

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21200072

  • [Journal Article] Induction of molecular chaperones as a therapeutic strategy for the polyglutamine diseases2010
    • Author(s)
      Nagai Y, Fujikake N, Popiel HA, Wada K
    • Journal Title

      Curr Pharm Biotechnol

      Volume: 11 Pages: 188-197

    • URL

      http://www.eurekaselect.com/71304/article

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21200072

  • [Journal Article] TDP-43プロテイノパチーの動物モデル2010
    • Author(s)
      永井義隆
    • Journal Title

      最新医学 65(7)

      Pages: 1603-1613

    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] Harnessing chaperone-mediated autophagy for the selective degradation ofmutant huntingtin protein.2010
    • Author(s)
      Bauer PO, Goswami A, Wong HK, Okuno M, Kurosawa M, Yamada M, Miyazaki H, Matsumoto G, Kino Y, Nagai Y, Nukina N
    • Journal Title

      Nature Biotechnology 28

      Pages: 256-63

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20059023

  • [Journal Article] Induction of molecular chaperones as a therapeutic strategy for the polyglutamine diseases2010
    • Author(s)
      Nagai Y, Fujikake N, Popiel HA, Wada K
    • Journal Title

      Current Pharmaceutical Biotechnology 11

      Pages: 188-97

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein.2010
    • Author(s)
      Bauer PO, Goswami A, Wong HK,Okuno M, Kurosawa M, Yamada M, Miyazaki H, Matsumoto G,Kino Y, Nagai Y, Nukina N
    • Journal Title

      Nature Biotechnology 28

      Pages: 256-63

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20056021

  • [Journal Article] TDP-43プロテイノパチーの動物モデル2010
    • Author(s)
      永井義隆、藤掛伸宏
    • Journal Title

      最新医学

      Volume: 65 Pages: 1603-1613

    • Data Source
      KAKENHI-PUBLICLY-21025042

  • [Journal Article] Induction of molecular chaperones as a therapeutic strategy for the polyglutamine diseases.2010
    • Author(s)
      Nagai Y, Fujikake N, Popiel HA, Wada K
    • Journal Title

      Current Pharmaceutical Biotechnology 11

      Pages: 188-97

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-21025042

  • [Journal Article] 脊髄小脳変性症2010
    • Author(s)
      永井義隆
    • Journal Title

      ドクターサロン

      Volume: 54 Pages: 729-732

    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] Genetic Testing for Huntington's Disease in Parkinsonism2010
    • Author(s)
      Rahman MS, Nagai Y, Popiel HA, Fujikake N, Okamoto Y, Ahmed MU, Islam MA, Islam MT, Ahmed S, Rahman KM, Uddin MJ, Dey SK, Ahmed Q, Hossain MA, Jahan N, Toda T
    • Journal Title

      Mymensingh Med J

      Volume: 19(4) Pages: 510-514

    • URL

      http://www.banglajol.info/index.php/MMJ/article/view/6708

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659172

  • [Journal Article] TDP-43プロテイノパチーの動物モデル2010
    • Author(s)
      永井義隆、藤掛伸宏
    • Journal Title

      最新医学

      Volume: 65 Pages: 1603-1613

    • Data Source
      KAKENHI-PUBLICLY-22020038

  • [Journal Article] 脊髄小脳変性症2010
    • Author(s)
      永井義隆
    • Journal Title

      ドクターサロン

      Volume: 54(10) Pages: 729-732

    • Data Source
      KAKENHI-PROJECT-22659172

  • [Journal Article] Induction of molecular chaperones as a therapeutic strategy for the polyglutamine diseases.2010
    • Author(s)
      Nagai Y, Fujikake N, Popiel HA, Wada K
    • Journal Title

      Current Pharmaceutical Biotechnology 11

      Pages: 188-97

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20059023

  • [Journal Article] Molecular pathogenesis of protein misfolding diseases : pathological molecular environments versus quahty control systems against misfolded proteins.2009
    • Author(s)
      Naiki H, Nagai Y
    • Journal Title

      Journal of Biochemistry 146

      Pages: 751-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20056021

  • [Journal Article] 神経疾患と分子シャペロン2009
    • Author(s)
      永井義隆
    • Journal Title

      Clinical Neuroscience 27(4)

      Pages: 368-369

    • Data Source
      KAKENHI-PROJECT-20023019

  • [Journal Article] 神経疾患とシャペロン2009
    • Author(s)
      永井義隆, 藤掛伸宏
    • Journal Title

      Clinical Neuroscience 27

      Pages: 368-9

    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] 神経疾患と分子シャペロン2009
    • Author(s)
      永井義隆
    • Journal Title

      Clinical Neuroscience 27(4)

      Pages: 368-369

    • Data Source
      KAKENHI-PROJECT-20056021

  • [Journal Article] ポリグルタミン病に対する蛋白質ミスフォールディング・凝集を標的とした分子治療2009
    • Author(s)
      永井義隆
    • Journal Title

      臨床神経学 49

      Pages: 913-6

    • NAID

      10026291101

    • Data Source
      KAKENHI-PROJECT-20023019

  • [Journal Article] 神経疾患とシャペロン2009
    • Author(s)
      永井義隆, 藤掛伸宏
    • Journal Title

      Clinical Neuroscience 27

      Pages: 368-9

    • Data Source
      KAKENHI-PROJECT-20056021

  • [Journal Article] Molecular pathogenesis of protein misfolding diseases : pathological molecular environments versus quality control systems against misfolded proteins.2009
    • Author(s)
      Naiki H, Nagai Y
    • Journal Title

      Journal of Biochemistry 146

      Pages: 751-6

    • NAID

      10026304899

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20023019

  • [Journal Article] Molecular pathogenesis of protein misfolding diseases : pathological molecular environments versus quality control systems against misfolded proteins2009
    • Author(s)
      Naiki H, Nagai Y
    • Journal Title

      Journal of Biochemistry 146

      Pages: 751-6

    • NAID

      10026304899

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] ポリグルタミン病に対する蛋白質ミスフォールディング・凝集を標的とした分子治療2009
    • Author(s)
      永井義隆
    • Journal Title

      臨床神経学 49

      Pages: 913-6

    • NAID

      10026291101

    • Data Source
      KAKENHI-PUBLICLY-21025042

  • [Journal Article] 神経疾患とシャペロン2009
    • Author(s)
      永井義隆, 藤掛伸宏
    • Journal Title

      Clinical Neuroscience 27

      Pages: 368-9

    • Data Source
      KAKENHI-PUBLICLY-21025042

  • [Journal Article] Molecular pathogenesis of protein misfolding diseases : Pathological molecular environments versus quality control systems against misfolded proteins2009
    • Author(s)
      Naiki H, Nagai Y
    • Journal Title

      J Biochem 146(6)

      Pages: 751-756

    • NAID

      10026304899

    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] 神経疾患と分子シャペロン2009
    • Author(s)
      永井義隆
    • Journal Title

      Clinical Neuroscience 27(4)

      Pages: 368-369

    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] 神経疾患とシャペロン2009
    • Author(s)
      永井義隆, 藤掛伸宏
    • Journal Title

      Clinical Neuroscience 27

      Pages: 368-9

    • Data Source
      KAKENHI-PROJECT-20059023

  • [Journal Article] 神経疾患と分子シャペロン2009
    • Author(s)
      永井義隆、藤掛伸宏
    • Journal Title

      Clinical Neuroscience 27(4)

      Pages: 368-369

    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] 脊髄小脳変性症-What's new?「遺伝子治療」2009
    • Author(s)
      永井義隆、ポピエル明子
    • Journal Title

      Clinical Neuroscience 27(1)

      Pages: 95-98

    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] 脊髄小脳変性症の遺伝子治療2009
    • Author(s)
      永井義隆
    • Journal Title

      Clinical Neuroscience 27(1)

      Pages: 95-98

    • Data Source
      KAKENHI-PROJECT-20056021

  • [Journal Article] Structure-activity relationship study on polyglutamine binding peptide QBP12009
    • Author(s)
      Tomita K, Popiel HA, Nagai Y, Toda T, Yoshimitsu Y, Ohno H, Oishi S, Fujii N
    • Journal Title

      Bioorg Med Chem 17(3)

      Pages: 1259-1263

    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] Surface plasmon resonance characterization of specific binding of polyglutamine aggregate inhibitors to the expanded polyglutamine stretch2009
    • Author(s)
      Okamoto Y, Nagai Y, Fujikake N, Popiel HA, Yoshioka T, Toda T, Inui T
    • Journal Title

      Biochem Biophys Res Commun 378(3)

      Pages: 634-639

    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] 脊髄小脳変性症の遺伝子治療2009
    • Author(s)
      永井義隆
    • Journal Title

      Clinical Neuroscience 27(1)

      Pages: 95-98

    • Data Source
      KAKENHI-PROJECT-20059023

  • [Journal Article] Molecular pathogenesis of protein misfolding diseases : pathological molecular environments versus quality control systems against misfolded proteins.2009
    • Author(s)
      Naiki H, Nagai Y
    • Journal Title

      Journal of Biochemistry 146

      Pages: 751-6

    • NAID

      10026304899

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20059023

  • [Journal Article] ポリグルタミン病に対する蛋白質ミスフォールディング・凝集を標的とした分子治療2009
    • Author(s)
      永井義隆
    • Journal Title

      臨床神経学 49

      Pages: 913-6

    • NAID

      10026291101

    • Data Source
      KAKENHI-PROJECT-20056021

  • [Journal Article] ポリグルタミン病に対する蛋白質ミスフォールディング・凝集を標的とした分子治療2009
    • Author(s)
      永井義隆
    • Journal Title

      臨床神経学 49

      Pages: 913-6

    • NAID

      10026291101

    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] Molecular pathogellesis of protein misfolding diseases : pathological molecular environments versus quality control systems against misfolded proteins.2009
    • Author(s)
      Naiki H, Nagai Y
    • Journal Title

      Journal of Biochemistry 146

      Pages: 751-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-21025042

  • [Journal Article] 神経疾患と分子シャペロン2009
    • Author(s)
      永井義隆
    • Journal Title

      Clinical Neuroscience 27(4)

      Pages: 368-369

    • Data Source
      KAKENHI-PROJECT-20059023

  • [Journal Article] Delivery of the aggregate inhibitor peptide QBP1 into the mouse brain using PTDs and its therapeutic effects on polyglutamine disease mice2009
    • Author(s)
      Popiel HA, Nagai Y, Fujikake N, Toda T
    • Journal Title

      Neurosci Lett 449(2)

      Pages: 87-92

    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] 脊髄小脳変性症の遺伝子治療2009
    • Author(s)
      永井義隆
    • Journal Title

      Clinical Neuroscience 27(1)

      Pages: 95-98

    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] ポリグルタミン病に対する蛋白質ミスフォールディング・凝集を標的とした分子治療2009
    • Author(s)
      永井義隆
    • Journal Title

      臨床神経学 49

      Pages: 913-6

    • NAID

      10026291101

    • Data Source
      KAKENHI-PROJECT-20059023

  • [Journal Article] Residual laminin-binding activity and enhanced dystroglycan glycosylation by LARGE in novel model mice to dystroglycanopathy2009
    • Author(s)
      Kanagawa M, Nishimoto A, Chiyonobu T, Takeda S, Miyagoe-Suzuki Y, Wang F, Fujikake N, Taniguchi M, Lu Z, Tachikawa M, Nagai Y, Tashiro F, Miyazaki J, Tajima Y, Takeda S, Endo T, Kobayashi K, Campbell KP, Toda T
    • Journal Title

      Hum Mol Genet 18(4)

      Pages: 621-631

    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] 脊髄小脳変性症の遺伝子治療2009
    • Author(s)
      永井義隆
    • Journal Title

      Clinical Neuroscience 27(1)

      Pages: 95-98

    • Data Source
      KAKENHI-PROJECT-20023019

  • [Journal Article] ポリグルタミン病に対する蛋白質ミスフォールディング・凝集を標的とした分子治療2009
    • Author(s)
      永井義隆
    • Journal Title

      臨床神経学 49(11)

      Pages: 913-916

    • NAID

      10026291101

    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] 神経疾患とシャペロン2009
    • Author(s)
      永井義隆, 藤掛伸宏
    • Journal Title

      Clinical Neuroscience 27

      Pages: 368-9

    • Data Source
      KAKENHI-PROJECT-20023019

  • [Journal Article] Conformational changes and aggregation of expanded polyglutamine proteins as therapeutic targets of the polyglutamine diseases : Exposed β-sheet hypothesis2008
    • Author(s)
      永井義隆, ポピエル明子
    • Journal Title

      Curr Pharm Des 14(30)

      Pages: 3267-3279

    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] Conformational changes and aggregation of expanded polyglutamine proteins as therapeutic targets of the polyglutamine diseases : Exposed β-sheet hypothesis2008
    • Author(s)
      Nagai, Y.
    • Journal Title

      Curr. Pharm. Des. 14(30)

      Pages: 3267-3279

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20059023

  • [Journal Article] Suppression of mutant huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability2008
    • Author(s)
      Kaminosono S, Saito T, Oyama F, Ohshima T, Asada A, Nagai Y, Nukina N, Hisanaga S
    • Journal Title

      J Neurosci 28(35)

      Pages: 8747-8755

    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] Conformational changes and aggregation of expanded polyglutamine proteins as therapeutic targets of the polyglutamine diseases : Exposed β-sheet hypothesis2008
    • Author(s)
      Nagai, Y.
    • Journal Title

      Curr. Pharm. Des. 14(30)

      Pages: 3267-3279

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] Heat shock transcription factor 1 (HSF1)-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones2008
    • Author(s)
      Fujikake N, Nagai Y, Popiel HA, Okamoto Y, Yamaguchi M, Toda T
    • Journal Title

      J Biol Chem 283(38)

      Pages: 26188-26197

    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] Conformational changes and aggregation of expanded polyglutamine proteins as therapeutic targets of the polyglutamine diseases : Exposed β-sheet hypothesis2008
    • Author(s)
      Nagai, Y.
    • Journal Title

      Curr. Pharm. Des. 14(30)

      Pages: 3267-3279

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20056021

  • [Journal Article] Conformational changes and aggregation of expanded polyglutamine proteins as therapeutic targets of the polyglutamine diseases : Exposed β-sheet hypothesis2008
    • Author(s)
      Nagai, Y.
    • Journal Title

      Curr. Pharm. Des. 14(30)

      Pages: 3267-3279

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20023019

  • [Journal Article] ER stress is the initial response to polyglutamine toxicity in PC12 cells2008
    • Author(s)
      Nakayama H, Hamada M, Fujikake N, Nagai Y, Zhao J, Hatano O, Shimoke K, Isosaki M, Yoshizumi M, Ikeuchi T
    • Journal Title

      Biochem Biophys Res Commun 377(2)

      Pages: 550-555

    • Data Source
      KAKENHI-PROJECT-20390245

  • [Journal Article] A toxic monomeric conformer of the polyglutamine protein.2007
    • Author(s)
      Nagai Y, et al.
    • Journal Title

      Nature Structural ＆ Molecular Biology 14・4

      Pages: 332-340

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590875

  • [Journal Article] A toxic monomeric conformer of the polyglutamine protein.2007
    • Author(s)
      Y. Nagai
    • Journal Title

      Nature Structural & Molecular Biology 14

      Pages: 332-340

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659226

  • [Journal Article] A toxic monomeric conformer of the polyglutamine protein.2007
    • Author(s)
      Y., Nagai
    • Journal Title

      Nature Structural & Molecular Biology 14

      Pages: 332-240

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18023025

  • [Journal Article] A toxic monomeric conformer of the polyglutamine protein.2007
    • Author(s)
      Y. Nagai
    • Journal Title

      Nature Structural & Molecular Biology 14

      Pages: 332-340

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18031024

  • [Journal Article] A toxic monomeric conformer of the polyglutamine protein.2007
    • Author(s)
      Nagai Y.
    • Journal Title

      Nature Structural ＆ Molecular Biology 14・4

      Pages: 332-340

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590875

  • [Journal Article] A toxic monomeric conformer of the polyglutamine protein.
    • Author(s)
      Y.Nagai
    • Journal Title

      Nature Structural ＆ Molecular Biology (in press)

    • Data Source
      KAKENHI-PROJECT-17590875

  • [Journal Article] A toxic monomeric conformer of the polyglutamine protein.
    • Author(s)
      Y.Nagai
    • Journal Title

      Nature Structural ＆ Molecular Biology (in press)

    • Data Source
      KAKENHI-PROJECT-18031024

  • [Journal Article] A toxic monomeric conformer of the polyglutamine protein.
    • Author(s)
      Y.Nagai
    • Journal Title

      Nature Structural ＆ Molecular Biology (in press)

    • Data Source
      KAKENHI-PROJECT-18023025

  • [Journal Article] A toxic monomeric conformer of the polyglutamine protein.
    • Author(s)
      Y.Nagai
    • Journal Title

      Nature Structural ＆ Molecular Biology (in press)

    • Data Source
      KAKENHI-PROJECT-17028035

  • [Journal Article] TDP-43 associates with stalled ribosomes and contributes to cell survival during cellular stress
    • Author(s)
      Shinji Higashi, Tomohiro Kabuta, Yoshitaka Nagai, Yukihiro Tsuchiya, Haruhiko Akiyama, Keiji Wada
    • Journal Title

      J Neurochem

      Volume: (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791008

  • [Patent] TDP-43プロテイノパチー治療用組成物2016
    • Inventor(s)
      長野清一、荒木敏之、上山盛夫、永井義隆
    • Industrial Property Rights Holder
      長野清一、荒木敏之、上山盛夫、永井義隆
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-087320
    • Filing Date
      2016-04-25
    • Data Source
      KAKENHI-PROJECT-16K09690

  • [Patent] 血液脳関門透過性ペプチド2015
    • Inventor(s)
      武内敏秀、永井義隆、中川慎介、丹羽正美、道具伸也、片岡泰文、他
    • Industrial Property Rights Holder
      京都大学、国立精神・神経医療研究センター、長崎大学・他、福岡大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-052967
    • Filing Date
      2015-03-17
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Patent] 血液脳関門透過性ペプチド2015
    • Inventor(s)
      武内敏秀、永井義隆、中川慎介、丹羽正美、道具伸也、片岡泰文、他
    • Industrial Property Rights Holder
      京都大学、国立精神・神経医療研究センター、長崎大学・他、福岡大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-052967
    • Filing Date
      2015-03-17
    • Data Source
      KAKENHI-PUBLICLY-25110741

  • [Patent] ALSの原因タンパク毒性を軽減する核酸2014
    • Inventor(s)
      石川欽也、水澤英洋、永井義隆、横田隆徳、石黒太郎、佐藤望、他
    • Industrial Property Rights Holder
      東京医科歯科大学、国立精神・神経医療研究センター
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-244034
    • Filing Date
      2014-12-02
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Patent] ALSの原因タンパク毒性を軽減する核酸2014
    • Inventor(s)
      石川欽也、水澤英洋、永井義隆、横田隆徳、石黒太郎、佐藤望、他
    • Industrial Property Rights Holder
      東京医科歯科大学、国立精神・神経医療研究センター
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-244034
    • Filing Date
      2014-12-02
    • Data Source
      KAKENHI-PUBLICLY-25110741

  • [Patent] 脊髄小脳失調症31型（SCA31治療剤）2014
    • Inventor(s)
      石川欽也、水澤英洋、永井義隆、石黒太郎、佐藤望、和田圭司
    • Industrial Property Rights Holder
      東京医科歯科大学、国立精神・神経医療研究センター
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-244350
    • Filing Date
      2014-12-02
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Patent] 脊髄小脳失調症31型（SCA31治療剤）2014
    • Inventor(s)
      石川欽也、水澤英洋、永井義隆、石黒太郎、佐藤望、和田圭司
    • Industrial Property Rights Holder
      東京医科歯科大学、国立精神・神経医療研究センター
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-244350
    • Filing Date
      2014-12-02
    • Data Source
      KAKENHI-PUBLICLY-25110741

  • [Presentation] ポリグルタミン蛋白質のミスフォールディング・凝集を標的とした脊髄小脳変性症の治療薬開発2021
    • Author(s)
      永井義隆
    • Organizer
      第11回 日本小脳学会学術集会
    • Invited
    • Data Source
      KAKENHI-PLANNED-20H05927

  • [Presentation] 骨格筋MRIで特徴的な画像異常を認めたサルコイドーシスの一例2021
    • Author(s)
      藤井佳奈子、坂田花美、福本雄太、谷口佳子、三井良之、永井義隆
    • Organizer
      第118回 日本神経学会近畿地方会
    • Data Source
      KAKENHI-PLANNED-20H05927

  • [Presentation] 神経変性疾患ポリグルタミン病に対するタンパク質凝集阻害薬L-アルギニンによる治療法開発2020
    • Author(s)
      永井義隆
    • Organizer
      第41回 日本臨床薬理学会
    • Invited
    • Data Source
      KAKENHI-PLANNED-20H05927

  • [Presentation] 神経変性疾患ポリグルタミン病に対するタンパク質凝集阻害薬QAI1の同定とその治療効果2020
    • Author(s)
      永井義隆、皆川栄子、ポピエルヘレナ明子、山根宏志、他田正義、高橋俊昭、武内敏秀、望月秀樹、戸田達史、和田圭司、小野寺理
    • Organizer
      第93回 日本薬理学会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] 運動による血漿由来エクソソーム分泌の亢進2020
    • Author(s)
      武田明子、武内敏秀、皆川栄子、和田圭司、永井義隆
    • Organizer
      第43回 日本神経科学会
    • Data Source
      KAKENHI-PLANNED-20H05927

  • [Presentation] ショウジョウバエモデルを用いたALS研究2020
    • Author(s)
      上山盛夫、永井義隆
    • Organizer
      第61回 日本神経学会学術大会
    • Invited
    • Data Source
      KAKENHI-PLANNED-20H05927

  • [Presentation] 国立精神・神経医療研究センターにおけるトランスジェニックマーモセット研究の現状2020
    • Author(s)
      中谷輝実、小杉亮人、小泉昌司、小島潮子、川野邊哲代、野上尚武、尾張健介、沼澤秀美、皆川栄子、武内敏秀、富岡郁夫、齊藤祐子、花川隆、永井義隆、和田圭司 、関和彦
    • Organizer
      第9回 日本マーモセット研究会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] ポリグルタミン蛋白質におけるプリオン様異常構造伝播機構2020
    • Author(s)
      小澤大作、武内敏秀、永井義隆
    • Organizer
      第18回 神経科学研究会
    • Data Source
      KAKENHI-PLANNED-20H05927

  • [Presentation] C9-ALS/FTDにおけるG4C2リピートRNA分解関連遺伝子の遺伝学的スクリーニング2020
    • Author(s)
      吉川碧、田港朝也、上山盛夫、永井義隆
    • Organizer
      第61回 日本神経学会学術大会
    • Data Source
      KAKENHI-PLANNED-20H05927

  • [Presentation] Difference between plasma-derived and serum-derived extracellular vesicles/2020
    • Author(s)
      張 暁曼、武内敏秀、永井義隆
    • Organizer
      第61回 日本神経学会学術大会
    • Data Source
      KAKENHI-PLANNED-20H05927

  • [Presentation] 神経変性疾患におけるリピート関連ATG非依存性（RAN）翻訳とその制御機構2020
    • Author(s)
      永井義隆
    • Organizer
      第93回 日本生化学会
    • Invited
    • Data Source
      KAKENHI-PLANNED-20H05927

  • [Presentation] SCA36モデルショウジョウバエの樹立2020
    • Author(s)
      田港朝也、上山盛夫、山下徹、池田佳生、阿部康二、永井義隆
    • Organizer
      第61回 日本神経学会学術大会
    • Data Source
      KAKENHI-PLANNED-20H05927

  • [Presentation] ポリグルタミン病に対する病態修飾治療薬の開発2020
    • Author(s)
      永井義隆
    • Organizer
      第61回 日本神経学会学術大会
    • Invited
    • Data Source
      KAKENHI-PLANNED-20H05927

  • [Presentation] 血清中細胞外小胞分画には凝固中に生成された血小板由来のナノ粒子が含まれている2020
    • Author(s)
      張 暁曼、武内敏秀、永井義隆
    • Organizer
      第43回 日本神経科学会
    • Data Source
      KAKENHI-PLANNED-20H05927

  • [Presentation] Identification of proteins in the cerebrospinal fluid of patients with Parkinson’s Disease that are associated with impaired sleep quality.2020
    • Author(s)
      Minakawa E.N., Yagihara H., Saitoh Y., Miyazaki M., Tsuru A., Suzuki M., Kamei Y., Ueda K., Wada K., Nagai Y.
    • Organizer
      Takeda Expert Conference on Parkinson's Disease
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] ショウジョウバエモデルを活用した神経変性疾患のトランスレーショナルリサーチ2020
    • Author(s)
      永井義隆
    • Organizer
      第43回 分子生物学会
    • Invited
    • Data Source
      KAKENHI-PLANNED-20H05927

  • [Presentation] Identification of proteins in the cerebrospinal fluid of patients with Parkinson’s Disease that are associated with impaired sleep quality.2020
    • Author(s)
      Minakawa E.N., Yagihara H., Saitoh Y., Miyazaki M., Tsuru A., Suzuki M., Kamei Y., Ueda K., Wada K., Nagai Y.
    • Organizer
      Takeda Expert Conference on Parkinson's Disease
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] 放射光を用いたレビー小体の微細構造解析2020
    • Author(s)
      荒木克哉、八木直人、永井義隆、後藤祐児、望月秀樹
    • Organizer
      第39回 日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PLANNED-20H05927

  • [Presentation] 神経変性疾患ポリグルタミン病に対するタンパク質凝集阻害薬QAI1の同定とその治療効果2020
    • Author(s)
      永井義隆、皆川栄子、ポピエルヘレナ明子、山根宏志、他田正義、高橋俊昭、武内敏秀、望月秀樹、戸田達史、和田圭司、小野寺理
    • Organizer
      第93回 日本薬理学会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Asidan (SCA36) の遺伝子変異とその病態メカニズム2020
    • Author(s)
      永井義隆
    • Organizer
      第61回 日本神経学会学術大会
    • Invited
    • Data Source
      KAKENHI-PLANNED-20H05927

  • [Presentation] 運動による神経変性抑制メカニズム2020
    • Author(s)
      武田明子、武内敏秀、皆川栄子、和田圭司、永井義隆
    • Organizer
      第61回 日本神経学会学術大会
    • Invited
    • Data Source
      KAKENHI-PLANNED-20H05927

  • [Presentation] Identification of cerebrospinal fluid proteins associated with impaired sleep quality in Parkinson’s disease.2019
    • Author(s)
      Minakawa E.N., Yagihara H., Saitoh Y., Tsuru A., Kamei Y., Ueda K., Wada K., Nagai Y.
    • Organizer
      The 5th World Parkinson Congress (WPC 2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Monitoring repeat-associated non-AUG (RAN) translation toward drug screening for ALS/FTD.2019
    • Author(s)
      橋本茜、武内敏秀、上山盛夫、森康治、池田学、永井義隆
    • Organizer
      第60回 日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Identification of target mRNA transported to axons by TDP-43.2019
    • Author(s)
      Nagano S, Ueyama M, Nagai Y, Mochizuki H, Araki T.
    • Organizer
      第15回成体脳ニューロン新生懇談会
    • Data Source
      KAKENHI-PROJECT-16K09690

  • [Presentation] hnRNPA3 alleviates the GGGGCC toxicity in C9orf72-linked ALS / FTD model Drosophila.2019
    • Author(s)
      田港朝也、上山盛夫、森康治、池田学、永井義隆
    • Organizer
      第60回 日本神経学会学術大会
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] 変異型α-シヌクレインフィブリルによるマウス脳でのレビー病理の形成2019
    • Author(s)
      馬場孝輔、早川英規、池中建介、Choong Chi-Jing、津田浩史、小池正人、長野清一、池内健、長谷川成人、永井義隆、望月秀樹
    • Organizer
      第42回 日本神経科学会・第62回 日本神経化学会合同大会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] RNAシャペロンとしてのTDP-43の新機能：異常伸長UGGAAリピートRNA凝集とリピート関連翻訳の制御による神経変性抑制2019
    • Author(s)
      永井義隆、石川欽也
    • Organizer
      第42回 分子生物学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] SCA36モデルショウジョウバエの樹立2019
    • Author(s)
      田港朝也、上山盛夫、山下徹、池田佳生、阿部康二、永井義隆
    • Organizer
      第42回 日本神経科学会・第62回 日本神経化学会合同大会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Prion-like conformational transmission of polyglutamine protein.2019
    • Author(s)
      小澤大作、武内敏秀、永井義隆
    • Organizer
      第60回 日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Dysfunction in an autophagy-lysosome degradation pathway promotes secretion of ubiquitinated proteins via extracellular vesicles.2019
    • Author(s)
      Takeuchi T., Sakai S., Ando H., Nagai Y.
    • Organizer
      Annual Meeting of International Society for Extracellular Vesicles (ISEV2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] E46K α-synuclein mutation gains resistance to degradation, leading to enhanced toxicity in PD flies.2019
    • Author(s)
      小澤大作、武内敏秀、永井義隆
    • Organizer
      第60回 日本神経学会学術大会
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] ポリグルタミン蛋白質によるプリオン様異常構造伝播2019
    • Author(s)
      小澤大作、武内敏秀、永井義隆
    • Organizer
      第14回 日本臨床ストレス応答学会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] 変異型α-シヌクレインフィブリルによるマウス脳でのレビー病理の形成2019
    • Author(s)
      馬場孝輔、早川英規、池中建介、Choong Chi-Jing、津田浩史、小池正人、長野清一、池内健、長谷川成人、永井義隆、望月秀樹
    • Organizer
      第42回 日本神経科学会・第62回 日本神経化学会合同大会
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] hnRNPA3はC9orf72関連FTDモデルショウジョウバエのリピートRNA毒性を軽減する2019
    • Author(s)
      田港朝也、上山盛夫、森康治、池田学、永井義隆
    • Organizer
      第38回 日本認知症学会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] 国立精神・神経医療研究センターにおけるトランスジェニックマーモセット研究の現状2019
    • Author(s)
      中谷輝実、小杉亮人、小泉昌司、小島潮子、川野邊哲代、野上尚武、尾張健介、沼澤秀美、皆川栄子、武内敏秀、富岡郁夫、齊藤祐子、花川隆、永井義隆、和田圭司 、関和彦
    • Organizer
      第9回 日本マーモセット研究会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] C9orf72関連筋萎縮性側索硬化症/前頭側頭型認知症モデルショウジョウバエにおける異常伸長リピートRNAとジペプチドリピートタンパク質の病態での役割2019
    • Author(s)
      上山盛夫、石黒太郎、今野卓哉、小山哲秀、石川欽也、和田圭司、小野寺理、永井義隆
    • Organizer
      第42回 日本神経科学会・第62回 日本神経化学会合同大会
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] Pathological roles of expanded repeat RNA and dipeptide repeat proteins in C9-ALS/FTD model fly. C9orf72関連筋萎縮性側索硬化症/前頭側頭型認知症モデルショウジョウバエにおける異常伸長リピートRNAとジペプチドリピートタンパク質の病態での役割2019
    • Author(s)
      上山盛夫、石黒太郎、今野卓哉、小山哲秀、石川欽也、和田圭司、小野寺理、永井義隆
    • Organizer
      第42回 日本神経科学会・第62回 日本神経化学会合同大会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] E46K α-synuclein mutation gains resistance to degradation, leading to enhanced toxicity in PD flies.2019
    • Author(s)
      堺竜介、鈴木マリ、上山盛夫、武内敏秀、望月秀樹、永井義隆
    • Organizer
      第60回 日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Spt4 knockdown suppressed SCA31-linked expanded UGGAA repeat-induced toxicity in Drosophila.2019
    • Author(s)
      石黒太郎、横田隆徳、石川欽也、永井義隆、Petrucelli L.
    • Organizer
      第60回 日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] hnRNPA3はC9orf72関連FTDモデルショウジョウバエのリピートRNA毒性を軽減する2019
    • Author(s)
      田港朝也、上山盛夫、森康治、池田学、永井義隆
    • Organizer
      第38回 日本認知症学会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Prion-like conformational transmission between polyglutamine protein monomers.2019
    • Author(s)
      Ozawa D., Takeuchi T., Nagai Y.
    • Organizer
      Asia Pacific Prion Symposium 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Identification of cerebrospinal fluid proteins associated with impaired sleep quality in Parkinson’s disease.2019
    • Author(s)
      Minakawa E.N., Yagihara H., Saitoh Y., Tsuru A., Kamei Y., Ueda K., Wada K., Nagai Y.
    • Organizer
      The 5th World Parkinson Congress (WPC 2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] 液-液相分離（LLPS）と非膜性オルガネラが関わる神経変性疾患の病態解明へ向けて2019
    • Author(s)
      永井義隆
    • Organizer
      第38回 日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] 運動は血漿由来エクソソーム分泌を亢進させる2019
    • Author(s)
      武田明子、武内敏秀、皆川栄子、永井義隆
    • Organizer
      第42回 分子生物学会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] 孤発性パーキンソン病遺伝子MCCC1におけるパーキンソン病発症メカニズム解析2019
    • Author(s)
      曽我部俊策、佐竹渉、小笠原佑介、中野浩子、上山盛夫、鈴木マリ、松本隆作、浜口哲矢、土井大輔、村山繁雄、高橋淳、青井貴之、永井義隆、戸田達史
    • Organizer
      第42回 日本神経科学会・第62回 日本神経化学会合同大会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Therapeutic strategy for the polyglutamine diseases targeting protein misfolding and aggregation.2019
    • Author(s)
      Nagai Y.
    • Organizer
      University of Gottingen, DZNE Seminar
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] Identification of cerebrospinal fluid proteins associated with impaired sleep quality in Parkinson’s disease.2019
    • Author(s)
      Minakawa E.N., Yagihara H., Saitoh Y., Tsuru A., Kamei Y., Ueda K., Wada K., Nagai Y.
    • Organizer
      The 5th World Parkinson Congress (WPC 2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] hnRNPA3 alleviates the GGGGCC toxicity in C9orf72-linked ALS / FTD model Drosophila.2019
    • Author(s)
      田港朝也、上山盛夫、森康治、池田学、永井義隆
    • Organizer
      第60回 日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] SCA36モデルショウジョウバエの樹立2019
    • Author(s)
      田港朝也、上山盛夫、山下徹、池田佳生、阿部康二、永井義隆
    • Organizer
      第42回 日本神経科学会・第62回 日本神経化学会合同大会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Structural basis of polyglutamine protein aggregation.2019
    • Author(s)
      Nagai Y.
    • Organizer
      The 3rd Ulm Meeting; Biophysics of Amyloid Formation
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Spt4 knockdown suppressed SCA31-linked expanded UGGAA repeat-induced toxicity in Drosophila.2019
    • Author(s)
      石黒太郎、横田隆徳、石川欽也、永井義隆、Petrucelli L.
    • Organizer
      第60回 日本神経学会学術大会
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] In vitroにおけるalpha-synuclein細胞外分泌機構の検討2019
    • Author(s)
      早川英規、馬場孝輔、Choong Chi-Jing、池中建介、武内敏秀、永井義隆、望月秀樹
    • Organizer
      第42回 日本神経科学会・第62回 日本神経化学会合同大会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Evidence for prion-like conformational transmission of a polyglutamine protein monomer.2019
    • Author(s)
      Nagai Y., Ozawa D., Takeuchi T.
    • Organizer
      10th Gordon Research Conference on CAG Triplet Repeat Disorders
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] 筋萎縮性側索硬化症におけるストレス顆粒形成と異常タンパク質凝集2019
    • Author(s)
      永井義隆
    • Organizer
      第92回 日本生化学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] 認知症・神経変性疾患バイオマーカーとしての血液中エクソソームの可能性2019
    • Author(s)
      永井義隆
    • Organizer
      第38回 日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] C9-ALS/FTDモデルショウジョウバエにおけるリピート関連非ATG翻訳の制御2019
    • Author(s)
      上山盛夫、石黒太郎、Gendron T.F.、今野卓哉、小山哲秀、和田圭司、石川欽也、小野寺理、Petrucelli L.、永井義隆
    • Organizer
      第38回 日本認知症学会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Dysfunction in an autophagy-lysosome degradation pathway promotes secretion of ubiquitinated proteins via extracellular vesicles.2019
    • Author(s)
      Takeuchi T., Sakai S., Ando H., Nagai Y.
    • Organizer
      Annual Meeting of International Society for Extracellular Vesicles (ISEV2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] Identification of proteins associated with impairment of sleep quality in cerebrospinal fluids of Parkinson’s disease patients.2019
    • Author(s)
      皆川栄子、八木原紘子、齊藤勇二、宮崎将行、都留あゆみ、鈴木みのり、亀井雄一、植田幸嗣、和田圭司、永井義隆
    • Organizer
      第42回 日本神経科学会・第62回 日本神経化学会合同大会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Evidence for prion-like conformational transmission of a polyglutamine protein monomer.2019
    • Author(s)
      Nagai Y., Ozawa D., Takeuchi T.
    • Organizer
      10th Gordon Research Conference on CAG Triplet Repeat Disorders
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] Structural basis of polyglutamine protein aggregation.2019
    • Author(s)
      Nagai Y.
    • Organizer
      The 3rd Ulm Meeting; Biophysics of Amyloid Formation
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Prion-like conformational transmission of polyglutamine protein.2019
    • Author(s)
      小澤大作、武内敏秀、永井義隆
    • Organizer
      第60回 日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Identification of proteins associated with impairment of sleep quality in cerebrospinal fluids of Parkinson’s disease patients.2019
    • Author(s)
      皆川栄子、八木原紘子、齊藤勇二、宮崎将行、都留あゆみ、鈴木みのり、亀井雄一、植田幸嗣、和田圭司、永井義隆
    • Organizer
      第42回 日本神経科学会・第62回 日本神経化学会合同大会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Identification of proteins in the cerebrospinal fluid of patients with Parkinson’s Disease that are associated with impaired sleep quality.2019
    • Author(s)
      Minakawa E.N., Yagihara H., Saitoh Y., Miyazaki M., Tsuru A., Suzuki M., Kamei Y., Ueda K., Wada K., Nagai Y.
    • Organizer
      Takeda Expert Conference on Parkinson's Disease
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] ポリグルタミン蛋白質によるプリオン様異常構造伝播2019
    • Author(s)
      小澤大作、武内敏秀、永井義隆
    • Organizer
      第7回 日本アミロイドーシス研究会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] ポリグルタミン蛋白質によるプリオン様異常構造伝播2019
    • Author(s)
      小澤大作、武内敏秀、永井義隆
    • Organizer
      第14回 日本臨床ストレス応答学会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] 神経変性疾患ポリグルタミン病に対するタンパク質凝集阻害薬QAI1の同定とその治療効果2019
    • Author(s)
      永井義隆、皆川栄子、ポピエルヘレナ明子、山根宏志、他田正義、高橋俊昭、武内敏秀、望月秀樹、戸田達史、和田圭司、小野寺理
    • Organizer
      第93回 日本薬理学会
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] Disease-modifying therapy for the polyglutamine diseases targeting protein misfolding and aggregation.2019
    • Author(s)
      Nagai Y.
    • Organizer
      The JSPS Core-toCore Program Seminar; Towards a cure for amyloid diseases
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] Therapeutic strategy for the polyglutamine diseases targeting protein misfolding and aggregation.2019
    • Author(s)
      Nagai Y.
    • Organizer
      University of Gottingen, DZNE Seminar
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] 筋萎縮性側索硬化症におけるストレス顆粒形成と異常タンパク質凝集2019
    • Author(s)
      永井義隆
    • Organizer
      第92回 日本生化学会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] ショウジョウバエモデルを活用した効率的な神経変性疾患研究2019
    • Author(s)
      永井義隆
    • Organizer
      第42回 日本神経科学会・第62回 日本神経化学会合同大会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] 変異型α-シヌクレインフィブリルによるマウス脳でのレビー病理の形成2019
    • Author(s)
      馬場孝輔、早川英規、池中建介、Choong Chi-Jing、津田浩史、小池正人、長野清一、池内健、長谷川成人、永井義隆、望月秀樹
    • Organizer
      第42回 日本神経科学会・第62回 日本神経化学会合同大会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] 液-液相分離（LLPS）と非膜性オルガネラが関わる神経変性疾患の病態解明へ向けて2019
    • Author(s)
      永井義隆
    • Organizer
      第38回 日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Prion-like conformational transmission between polyglutamine protein monomers.2019
    • Author(s)
      Ozawa D., Takeuchi T., Nagai Y.
    • Organizer
      Asia Pacific Prion Symposium 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] 孤発性パーキンソン病遺伝子MCCC1におけるパーキンソン病発症メカニズム解析2019
    • Author(s)
      曽我部俊策、佐竹渉、小笠原佑介、中野浩子、上山盛夫、鈴木マリ、松本隆作、浜口哲矢、土井大輔、村山繁雄、高橋淳、青井貴之、永井義隆、戸田達史
    • Organizer
      第42回 日本神経科学会・第62回 日本神経化学会合同大会
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] Conformational transmission between polyglutamine protein monomers.2019
    • Author(s)
      Ozawa D., Takeuchi T., Nagai Y.
    • Organizer
      The JSPS Core-toCore Program Seminar; Towards a cure for amyloid diseases
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Conformational transmission between polyglutamine protein monomers.2019
    • Author(s)
      Ozawa D., Takeuchi T., Nagai Y.
    • Organizer
      The JSPS Core-toCore Program Seminar; Towards a cure for amyloid diseases
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] Monitoring repeat-associated non-AUG (RAN) translation toward drug screening for ALS/FTD.2019
    • Author(s)
      橋本茜、武内敏秀、上山盛夫、森康治、池田学、永井義隆
    • Organizer
      第60回 日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] C9-ALS/FTDモデルショウジョウバエにおけるリピート関連非ATG翻訳の制御2019
    • Author(s)
      上山盛夫、石黒太郎、Gendron T.F.、今野卓哉、小山哲秀、和田圭司、石川欽也、小野寺理、Petrucelli L.、永井義隆
    • Organizer
      第38回 日本認知症学会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Spt4 knockdown suppressed SCA31-linked expanded UGGAA repeat-induced toxicity in Drosophila.2019
    • Author(s)
      石黒太郎、横田隆徳、石川欽也、永井義隆、Petrucelli L.
    • Organizer
      第60回 日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Disease-modifying therapy for the polyglutamine diseases targeting protein misfolding and aggregation.2019
    • Author(s)
      Nagai Y.
    • Organizer
      The JSPS Core-toCore Program Seminar; Towards a cure for amyloid diseases
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] ポリグルタミン蛋白質によるプリオン様異常構造伝播2019
    • Author(s)
      小澤大作、武内敏秀、永井義隆
    • Organizer
      第14回 日本臨床ストレス応答学会
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] ショウジョウバエモデルを活用した効率的な神経変性疾患研究2019
    • Author(s)
      永井義隆
    • Organizer
      第42回 日本神経科学会・第62回 日本神経化学会合同大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Monitoring repeat-associated non-AUG (RAN) translation toward drug screening for ALS/FTD.2019
    • Author(s)
      橋本茜、武内敏秀、上山盛夫、森康治、池田学、永井義隆
    • Organizer
      第60回 日本神経学会学術大会
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] Conformational transmission between polyglutamine protein monomers.2019
    • Author(s)
      Ozawa D., Takeuchi T., Nagai Y.
    • Organizer
      The JSPS Core-toCore Program Seminar; Towards a cure for amyloid diseases
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] hnRNPA3はC9orf72関連FTDモデルショウジョウバエのリピートRNA毒性を軽減する2019
    • Author(s)
      田港朝也、上山盛夫、森康治、池田学、永井義隆
    • Organizer
      第38回 日本認知症学会
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] ショウジョウバエモデルを活用した効率的な神経変性疾患研究2019
    • Author(s)
      永井義隆
    • Organizer
      第42回 日本神経科学会・第62回 日本神経化学会合同大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] In vitroにおけるalpha-synuclein細胞外分泌機構の検討2019
    • Author(s)
      早川英規、馬場孝輔、Choong Chi-Jing、池中建介、武内敏秀、永井義隆、望月秀樹
    • Organizer
      第42回 日本神経科学会・第62回 日本神経化学会合同大会
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] E46K α-synuclein mutation confers degradation resistance in Parkinson’s disease model flies.2019
    • Author(s)
      堺竜介、鈴木マリ、上山盛夫、武内敏秀、望月秀樹、永井義隆
    • Organizer
      第13回 パーキンソン病・運動障害疾患コングレス
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] 運動は血漿由来エクソソーム分泌を亢進させる2019
    • Author(s)
      武田明子、武内敏秀、皆川栄子、永井義隆
    • Organizer
      第42回 分子生物学会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] 認知症・神経変性疾患バイオマーカーとしての血液中エクソソームの可能性2019
    • Author(s)
      永井義隆
    • Organizer
      第38回 日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] 孤発性パーキンソン病遺伝子MCCC1におけるパーキンソン病発症メカニズム解析2019
    • Author(s)
      曽我部俊策、佐竹渉、小笠原佑介、中野浩子、上山盛夫、鈴木マリ、松本隆作、浜口哲矢、土井大輔、村山繁雄、高橋淳、青井貴之、永井義隆、戸田達史
    • Organizer
      第42回 日本神経科学会・第62回 日本神経化学会合同大会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Evidence for prion-like conformational transmission of a polyglutamine protein monomer.2019
    • Author(s)
      Nagai Y., Ozawa D., Takeuchi T.
    • Organizer
      10th Gordon Research Conference on CAG Triplet Repeat Disorders
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Identification of proteins associated with impairment of sleep quality in cerebrospinal fluids of Parkinson’s disease patients.2019
    • Author(s)
      皆川栄子、八木原紘子、齊藤勇二、宮崎将行、都留あゆみ、鈴木みのり、亀井雄一、植田幸嗣、和田圭司、永井義隆
    • Organizer
      第42回 日本神経科学会・第62回 日本神経化学会合同大会
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] E46K α-synuclein mutation confers degradation resistance in Parkinson’s disease model flies.2019
    • Author(s)
      堺竜介、鈴木マリ、上山盛夫、武内敏秀、望月秀樹、永井義隆
    • Organizer
      第13回 パーキンソン病・運動障害疾患コングレス
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Prion-like conformational transmission between polyglutamine protein monomers.2019
    • Author(s)
      Ozawa D., Takeuchi T., Nagai Y.
    • Organizer
      Asia Pacific Prion Symposium 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] SCA36モデルショウジョウバエの樹立2019
    • Author(s)
      田港朝也、上山盛夫、山下徹、池田佳生、阿部康二、永井義隆
    • Organizer
      第42回 日本神経科学会・第62回 日本神経化学会合同大会
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] C9orf72関連筋萎縮性側索硬化症/前頭側頭型認知症モデルショウジョウバエにおける異常伸長リピートRNAとジペプチドリピートタンパク質の病態での役割2019
    • Author(s)
      上山盛夫、石黒太郎、今野卓哉、小山哲秀、石川欽也、和田圭司、小野寺理、永井義隆
    • Organizer
      第42回 日本神経科学会・第62回 日本神経化学会合同大会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Comparison of serum and plasma as a source of blood extracellular vesicles reveals possible contamination of serum with platelet-derived particles produced during coagulation.2019
    • Author(s)
      Zhang X., Takeuchi T., Nagai Y.
    • Organizer
      Annual Meeting of International Society for Extracellular Vesicles (ISEV2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] In vitroにおけるalpha-synuclein細胞外分泌機構の検討2019
    • Author(s)
      早川英規、馬場孝輔、Choong Chi-Jing、池中建介、武内敏秀、永井義隆、望月秀樹
    • Organizer
      第42回 日本神経科学会・第62回 日本神経化学会合同大会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] E46K α-synuclein mutation gains resistance to degradation, leading to enhanced toxicity in PD flies.2019
    • Author(s)
      堺竜介、鈴木マリ、上山盛夫、武内敏秀、望月秀樹、永井義隆
    • Organizer
      第60回 日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] RNAシャペロンとしてのTDP-43の新機能：異常伸長UGGAAリピートRNA凝集とリピート関連翻訳の制御による神経変性抑制2019
    • Author(s)
      永井義隆、石川欽也
    • Organizer
      第42回 分子生物学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Structural basis of polyglutamine protein aggregation.2019
    • Author(s)
      Nagai Y.
    • Organizer
      The 3rd Ulm Meeting; Biophysics of Amyloid Formation
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] 液-液相分離（LLPS）と非膜性オルガネラが関わる神経変性疾患の病態解明へ向けて2019
    • Author(s)
      永井義隆
    • Organizer
      第38回 日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] RNAシャペロンとしてのTDP-43の新機能：異常伸長UGGAAリピートRNA凝集とリピート関連翻訳の制御による神経変性抑制2019
    • Author(s)
      永井義隆、石川欽也
    • Organizer
      第42回 分子生物学会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] 筋萎縮性側索硬化症におけるストレス顆粒形成と異常タンパク質凝集2019
    • Author(s)
      永井義隆
    • Organizer
      第92回 日本生化学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] ポリグルタミン蛋白質によるプリオン様異常構造伝播2019
    • Author(s)
      小澤大作、武内敏秀、永井義隆
    • Organizer
      第7回 日本アミロイドーシス研究会
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] C9-ALS/FTDモデルショウジョウバエにおけるリピート関連非ATG翻訳の制御2019
    • Author(s)
      上山盛夫、石黒太郎、Gendron T.F.、今野卓哉、小山哲秀、和田圭司、石川欽也、小野寺理、Petrucelli L.、永井義隆
    • Organizer
      第38回 日本認知症学会
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] 国立精神・神経医療研究センターにおけるトランスジェニックマーモセット研究の現状2019
    • Author(s)
      中谷輝実、小杉亮人、小泉昌司、小島潮子、川野邊哲代、野上尚武、尾張健介、沼澤秀美、皆川栄子、武内敏秀、富岡郁夫、齊藤祐子、花川隆、永井義隆、和田圭司 、関和彦
    • Organizer
      第9回 日本マーモセット研究会
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] Comparison of serum and plasma as a source of blood extracellular vesicles reveals possible contamination of serum with platelet-derived particles produced during coagulation.2019
    • Author(s)
      Zhang X., Takeuchi T., Nagai Y.
    • Organizer
      Annual Meeting of International Society for Extracellular Vesicles (ISEV2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] ポリグルタミン蛋白質によるプリオン様異常構造伝播2019
    • Author(s)
      小澤大作、武内敏秀、永井義隆
    • Organizer
      第7回 日本アミロイドーシス研究会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Comparison of serum and plasma as a source of blood extracellular vesicles reveals possible contamination of serum with platelet-derived particles produced during coagulation.2019
    • Author(s)
      Zhang X., Takeuchi T., Nagai Y.
    • Organizer
      Annual Meeting of International Society for Extracellular Vesicles (ISEV2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] 認知症・神経変性疾患バイオマーカーとしての血液中エクソソームの可能性2019
    • Author(s)
      永井義隆
    • Organizer
      第38回 日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] hnRNPA3 alleviates the GGGGCC toxicity in C9orf72-linked ALS / FTD model Drosophila.2019
    • Author(s)
      田港朝也、上山盛夫、森康治、池田学、永井義隆
    • Organizer
      第60回 日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] E46K α-synuclein mutation confers degradation resistance in Parkinson’s disease model flies.2019
    • Author(s)
      堺竜介、鈴木マリ、上山盛夫、武内敏秀、望月秀樹、永井義隆
    • Organizer
      第13回 パーキンソン病・運動障害疾患コングレス
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] 運動は血漿由来エクソソーム分泌を亢進させる2019
    • Author(s)
      武田明子、武内敏秀、皆川栄子、永井義隆
    • Organizer
      第42回 分子生物学会
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] オートファジー機能障害による細胞外小胞分泌2018
    • Author(s)
      武内敏秀、永井義隆
    • Organizer
      第91回 日本生化学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Therapeutic strategy for the polyglutamine diseases targeting the toxic protein conformational transition and aggregation.2018
    • Author(s)
      Nagai Y.
    • Organizer
      4th International Symposium for Molecular Neurodegenerative Disease Research
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Establishment of α-synuclein transgenic Drosophila model by site-specific transgenesis.2018
    • Author(s)
      堺竜介、鈴木マリ、上山盛夫、武内敏秀、永井義隆、望月秀樹
    • Organizer
      第59回 日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] DNAJC13 mutation aggravates alpha-synuclein-induced toxicity through perturbation of trafficking.2018
    • Author(s)
      吉田隼、長谷川隆文、鈴木マリ、菅野直人、小林潤平、上山盛夫、福田光則、藤林明美、関口清俊、江面道典、菊池昭夫、馬場徹、武田篤、望月秀樹、永井義隆、青木正志
    • Organizer
      第59回 日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Identification of target mRNA transported to axons by TDP-43.2018
    • Author(s)
      Nagano S, Ueyama M, Nagai Y, Mochizuki H, Araki T.
    • Organizer
      143rd Annual Meeting of the American Neurological Association
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09690

  • [Presentation] ショウジョウバエモデルによるC9-ALS/FTDの病態解明2018
    • Author(s)
      上山盛夫、石黒太郎、今野卓哉、小山哲秀、望月秀樹、和田圭司、石川欽也、小野寺理、Leonard Petrucelli、永井義隆
    • Organizer
      第37回 日本認知症学会学術集会
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] 神経変性疾患バイオマーカーとしての血液中エクソソームの可能性2018
    • Author(s)
      永井義隆
    • Organizer
      第61回 日本神経化学会・第40回 日本生物学的精神医学会合同年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] 迅速化凝集アッセイと線虫モデルの組み合わせによるシヌクレイン凝集阻害薬スクリーニング2018
    • Author(s)
      池中建介、角田渓太、馬場孝輔、荒木克哉、武内敏秀、園田静夏、永井義隆、後藤祐児、望月秀樹
    • Organizer
      第12回 パーキンソン病・運動障害疾患コングレス
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Establishment of slowly progressive Parkinson's disease marmoset model by α-synuclein fibril injection.2018
    • Author(s)
      Yabumoto T., Baba K., Hayakawa H., Yoshida F., Uehara T., Nakatani R., Ikenaka K., Tsuda H., Nagano S., Nagai Y., Hamanaka H., Hirata M., Mochizuki H.
    • Organizer
      The 143rd Annual Meeting of the American Neurological Association
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] ポリグルタミン蛋白質のβシート構造転移・プリオン様構造伝播と治療戦略2018
    • Author(s)
      永井義隆
    • Organizer
      第6回 日本アミロイドーシス研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] TDP-43のRNAシャペロンとしての新機能：脊髄小脳失調症31型（SCA31）の変異RNA凝集とリピート関連翻訳に対する制御機構2018
    • Author(s)
      永井義隆、石川欽也
    • Organizer
      第91回 日本生化学会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] Structural basis of polyglutamine protein aggregation and propagation, and its therapeutic opportunities.2018
    • Author(s)
      永井義隆
    • Organizer
      第41回 日本神経科学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] ポリグルタミン蛋白質による異常構造伝播機構の解明2018
    • Author(s)
      小澤大作、武内敏秀、永井義隆
    • Organizer
      第18回 日本蛋白質科学会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] 不要タンパク質の蓄積ストレス下における細胞外小胞分泌2018
    • Author(s)
      武内敏秀、坂井聖子、永井義隆
    • Organizer
      第13回 臨床ストレス応答学会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Role of RNA chaperone TDP-43 in the pathogenesis of spinocerebellar ataxia type 31 (SCA31).2018
    • Author(s)
      Ishiguro T., Sato N., Ueyama M., Fujikake N., Sellier C., Charlet-Berguerand N., Zamiri B., Gall-Duncan T., Mirceta M., Taylor J.P., Pearson C.E., Mizusawa H., Nagai Y., Ishikawa K.
    • Organizer
      9th International Conference on Unstable Microsatellites and Human Disease
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] ノンコーディングリピート病におけるRNA凝集、RAN翻訳と神経変性メカニズム2018
    • Author(s)
      永井義隆、石川欽也
    • Organizer
      第37回 日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] 神経変性疾患ノンコーディングリピート病におけるリピート関連ATG非依存性（RAN）翻訳の制御メカニズム2018
    • Author(s)
      永井義隆
    • Organizer
      第41回 分子生物学会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] C9orf72連鎖性ALS/FTDショウジョウバエモデルにおけるRAN翻訳と神経変性メカニズム2018
    • Author(s)
      永井義隆
    • Organizer
      第40回 神経組織培養研究会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] hnRNPA3はC9orf72関連筋萎縮性側索硬化症/前頭側頭型認知症モデルショウジョウバエのGGGGCC repeat RNA毒性を軽減する2018
    • Author(s)
      田港朝也、上山盛夫、森康治、池田学、永井義隆
    • Organizer
      第41回 日本神経科学会
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] Molecular-targeted therapy for polyglutamine diseases.2018
    • Author(s)
      Nagai Y.
    • Organizer
      The 75th Fujihara Seminar: Cereberum as CNS hub
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Disruption of TDP-43 autoregulation lead to formation of cytoplasmic aggregates.2018
    • Author(s)
      前田和宏、武内敏秀、藤原健志、松田誠司、閨正博、永井義隆
    • Organizer
      第59回 日本神経学会学術大会
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] Dissection of the pathogenic roles of expanded repeat RNA and dipeptide repeat proteins in C9-ALS/FTD model fly.2018
    • Author(s)
      Ueyama M., Ishiguro T., Gendron T.F., Konno T., Koyama A., Ishikawa K., Wada K., Onodera O., Petrucelli L., Nagai Y.
    • Organizer
      5th RNA Metabolism in Neurological Disease Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] Inhibition of autophagy promotes secretion of autophagy-related proteins via extracellular vesicles.2018
    • Author(s)
      Takeuchi T., Sakai S., Nagai Y.
    • Organizer
      Keystone Symposia on Selective Autophagy
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Molecular therapy for the polyglutamine diseases using the aggregate inhibitor peptide QBP1.2018
    • Author(s)
      Nagai Y.
    • Organizer
      10th International Peptide Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Identification of target mRNA transported to axons by TDP-43.2018
    • Author(s)
      Nagano S., Ueyama M., Nagai Y., Mochizuki H., Araki T.
    • Organizer
      The 143rd Annual Meeting of the American Neurological Association
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] リピート病研究の新たな展開2018
    • Author(s)
      永井義隆
    • Organizer
      第63回 日本人類遺伝学会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] α-synuclein aggregation and propagation in the marmoset brain deteriorates its motor function.2018
    • Author(s)
      薮本大紀、馬場孝輔、早川英規、池中建介、吉田史章、上原拓也、仲谷利栄、宮内英昭、津田浩史、長野清一、濱中裕喜、永井義隆、平田雅之、望月秀樹
    • Organizer
      第41回 日本神経科学会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] リピート病研究の新たな展開2018
    • Author(s)
      永井義隆
    • Organizer
      第63回 日本人類遺伝学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Conformational transition, transmission and aggregation of polyglutamine protein, and its therapeutic strategy.2018
    • Author(s)
      永井義隆
    • Organizer
      第18回 日本蛋白質科学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] C9orf72連鎖性ALS/FTDにおけるRAN翻訳と神経変性メカニズム2018
    • Author(s)
      永井義隆
    • Organizer
      第59回 日本神経学会学術大会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-17H05699

  • [Presentation] Glucocerebrosidase（GBA）遺伝子変異によるパーキンソン病の発症メカニズム2017
    • Author(s)
      永井義隆、鈴木マリ
    • Organizer
      第40回 日本分子生物学会・第90回 日本生化学会（ワークショップ）
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] GBA機能喪失はα-シヌクレインの異常構造変化を促進して神経変性を悪化させる2017
    • Author(s)
      鈴木マリ、藤掛伸宏、武内敏秀、香山(古金谷)綾子、中嶋和紀、平林義雄、和田圭司、三五一憲、永井義隆
    • Organizer
      第36回 日本認知症学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] p62/SQSTM1 contributes to the autophagic clearance of toxic protein oligomers in neurodegenerative diseases.2017
    • Author(s)
      Nagai Y., Saitoh Y.
    • Organizer
      The 8th International Symposium on Autophagy
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] パーキンソン病におけるαシヌクレイン-脂質相互作用の役割2017
    • Author(s)
      鈴木マリ、永井義隆
    • Organizer
      第12回 臨床ストレス応答学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] エクソソームを介する非細胞自律的な蛋白質凝集・神経変性の抑制2017
    • Author(s)
      永井義隆
    • Organizer
      第36回 日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] 細胞外小胞の分泌・伝播を介した生体内プロテオスタシス制御2017
    • Author(s)
      武内敏秀、永井義隆
    • Organizer
      第40回 日本分子生物学会・第90回 日本生化学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] リピート関連非ATG依存性翻訳の制御による筋委縮性側索硬化症の病態メカニズム解明2017
    • Author(s)
      永井義隆、上山盛夫
    • Organizer
      第40回日本神経科学会 (シンポジウム)
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Generation of transgenic monkey with tetracyclin-inducible gene expression system for neurodegenerative disease model.2017
    • Author(s)
      18.Tomioka I., Nogami N., Fujita N., Owari K., Nakatani T., Motohashi H., Takayama O., Nagai Y., Seki K.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] In vitro assessment of extracellular α-synuclein secretion.2017
    • Author(s)
      Hayakawa H., Baba K., Takeuchi T., Choong C.J., Nagano S., Nagai Y., Hagihara K., Mochizuki H.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Parkinson’s disease-linked DNAJC13 mutation aggravates α-synuclein-induced neurotoxicity through perturbation of endosomal trafficking.2017
    • Author(s)
      Hasegawa T., Yoshida S., Suzuki M., Sugeno N., Kobayashi J., Ueyama M., Ezura M., Kikuchi A., Baba T., Takeda A., Mochizuki H., Nagai Y., Aoki M.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Go-Sha-Jinki-Gan (GJG) palliates inflammation in experimental autoimmune encephalomyelitis (EAE) mice.2017
    • Author(s)
      Jiang S., Baba K., Okuno T., Hayakawa H., Ikenaka K., Sasaki T., Nagano S., Nagai Y., Hagihara K., Mochizuki H.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Glucocerebrosidase（GBA）遺伝子変異によるパーキンソン病の発症メカニズム Molecular pathomechanisms of glucocerebrosidase (GBA)-linked Parkinson’s disease2017
    • Author(s)
      永井義隆、鈴木マリ
    • Organizer
      第40回 日本分子生物学会・第90回 日本生化学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] パーキンソン病におけるαシヌクレイン-脂質相互作用の役割2017
    • Author(s)
      鈴木マリ、永井義隆
    • Organizer
      第12回 臨床ストレス応答学会（シンポジウム）
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Go-Sha-Jinki-Gan (GJG) palliates inflammation in experimental autoimmune encephalomyelitis (EAE) mice.2017
    • Author(s)
      Jiang S., Baba K., Okuno T., Hayakawa H., Ikenaka K., Sasaki T., Nagano S., Nagai Y., Hagihara K., Mochizuki H.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] 慢性的な中途覚醒の増加はアルツハイマー病モデルマウスのアミロイドβ病理を悪化させる2017
    • Author(s)
      皆川栄子、宮崎歴、丸尾和司、八木原紘子、藤田寛美、和田圭司、永井義隆
    • Organizer
      第12回 臨床ストレス応答学会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Balance between RNA binding proetin TDP-43 and an RNA UGGAA repeat underlies pathogenesis of spinocerebellar ataxia type 31 (SCA31) and motor neuron disease fly models.2017
    • Author(s)
      13.Ishiguro T., Sato N., Ueyama M., Fujikake N., Sellier C., Tokuda E., Zamiri B., Gall-Duncan T., Mirceta M., Furukawa Y., Yokota T., Wada K., Taylor J.P., Pearson C.E., Charlet-Berguerand N., Mizusawa H., Nagai Y., Ishikawa K.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Regulatory role of RNA chaperone for noncoding repeat RNA aggregation and repeat-associated translation in SCA31.2017
    • Author(s)
      Nagai Y., Ishiguro T., Sato N., Ueyama M., Fujikake N., Yokota T., Wada K., Mizusawa H., Ishikawa K.
    • Organizer
      The 43rd Naito Conference on Noncoding RNA：Biology, Chemistry, & Diseases
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] The structure analysis for α-synuclein and Lewy bodies in the brain of Parkinson’s disease patients with synchrotron radiation.2017
    • Author(s)
      荒木克哉、八木直人、池中健介、早川英規、馬場孝輔、永井義隆、後藤祐児、望月秀樹
    • Organizer
      第60回 日本神経化学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] 中途覚醒の増加はアルツハイマー病モデルマウスのアミロイドβ病理を悪化させる2017
    • Author(s)
      皆川栄子、宮崎歴、丸尾和司、盆子原紘子、藤田寛美、和田圭司、永井義隆
    • Organizer
      第40回 日本神経科学会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Transgenic monkey model of the polyglutamine diseases recapitulating progressive neurological symptoms and polyglutamine protein inclusions.2017
    • Author(s)
      Nagai Y., Tomioka I., Ishibashi H., Minakawa E.N, Motohashi H.H., Takayama O., Saito Y., Popiel H.A., Puentes S., Owari K., Nakatani T., Nogami N., Yamamoto K., Noguchi S., Nagano S., Nishino I., Ichinohe N., Wada K., Kohsaka S., Seki K.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Loss of function mutant of ter94, Drosophila VCP, partially enhanced motor neuron degeneration induced by knockdown of TBPH, Drosophila TDP-43.2017
    • Author(s)
      Kushimura Y., Tokuda T., Azuma Y., Yamamoto I., Ueoka I., Mizuta I., Mizuno T., Nakagawa M., Ueyama M., Nagai Y., Yoshida H., Yamaguchi M.
    • Organizer
      CSHL 2017 Neurobiology of Drosophila
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] ポリグルタミン病モデルマーモセットのライン化及び表現型解析2017
    • Author(s)
      野上尚武、尾張健介、中谷輝美、小泉昌司、佐賀洋介、川野邊哲代、永井義隆、富岡郁夫、関和彦
    • Organizer
      第40回 日本神経科学会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Elucidating the pathological mechanisms of amyotrophic lateral sclerosis/ frontotemporal dementia using Drosophila models.2017
    • Author(s)
      上山盛夫、永井義隆
    • Organizer
      第89回 日本遺伝学会大会 (受賞講演)
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] ter94機能喪失変異はTBPHノックダウンによるALSショウジョウバエモデルの表現型を増悪する2017
    • Author(s)
      櫛村由紀恵、徳田隆彦、東裕美子、山本格、上岡伊吹、水田依久子、水野 敏樹、中川正法、上山盛夫、永井義隆、吉田英樹、山口政光
    • Organizer
      第40回 日本分子生物学会・第90回 日本生化学会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] The search for genes that modulate FUS-mediated phenotypes by Drosophila amyotrophic lateral sclerosis model.2017
    • Author(s)
      東裕美子、徳田隆彦、櫛村由紀恵、山本格、上岡伊吹、吉田英樹、水田依久子、上山盛夫、永井義隆、中川正法、水野 敏樹、山口政光
    • Organizer
      第40回 日本分子生物学会・第90回 日本生化学会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] 細胞外小胞の分泌・伝播を介した生体内プロテオスタシス制御2017
    • Author(s)
      武内敏秀、永井義隆
    • Organizer
      第40回 日本分子生物学会・第90回 日本生化学会（ワークショップ）
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Loss of function mutant of ter94, Drosophila VCP, partially enhanced motor neuron degeneration induced by knockdown of TBPH, Drosophila TDP-43.2017
    • Author(s)
      Kushimura Y., Tokuda T., Azuma Y., Yamamoto I., Yoshida H., Mizuta I., Ueyama M., Nagai Y., Nakagawa M., Mizuno T., Yamaguchi M.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] C9orf72関連筋萎縮性側索硬化症/前頭側頭型認知症モデルショウジョウバエにおけるリピート関連非ATG翻訳の制御2017
    • Author(s)
      上山盛夫、石黒太郎、藤掛伸宏、今野卓哉、小山哲秀、小野寺理、石川欽也、和田圭司、永井義隆
    • Organizer
      第40回 日本神経科学会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] エクソソームを介する非細胞自律的な蛋白質凝集・神経変性の抑制2017
    • Author(s)
      永井義隆
    • Organizer
      第36回 日本認知症学会学術集会（学会賞受賞講演）
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] C9orf72関連筋萎縮性側索硬化症/前頭側頭型認知症モデルショウジョウバエにおけるリピート関連非ATG翻訳の制御2017
    • Author(s)
      上山盛夫、石黒太郎、藤掛伸宏、今野卓哉、小山哲秀、小野寺理、石川欽也、和田圭司、永井義隆
    • Organizer
      第40回 日本神経科学会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] The search for genes that modulate FUS-mediated phenotypes by Drosophila amyotrophic lateral sclerosis model.2017
    • Author(s)
      Azuma Y., Tokuda T., Kushimura Y., Yamamoto I., Yoshida H., Mizuta I., Ueyama M., Nagai Y., Nakagawa M., Mizuno T., Yamaguchi M.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Loss of function mutant of ter94, Drosophila VCP, partially enhanced motor neuron degeneration induced by knockdown of TBPH, Drosophila TDP-43.2017
    • Author(s)
      Kushimura Y., Tokuda T., Azuma Y., Yamamoto I., Yoshida H., Mizuta I., Ueyama M., Nagai Y., Nakagawa M., Mizuno T., Yamaguchi M.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] The structure analysis for α-synuclein and Lewy bodies in the brain of Parkinson’s disease patients with synchrotron radiation.2017
    • Author(s)
      荒木克哉、八木直人、池中健介、早川英規、馬場孝輔、永井義隆、後藤祐児、望月秀樹
    • Organizer
      第60回 日本神経化学会（シンポジウム）
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Regulatory role of TDP-43 as an RNA chaperone for RNA aggregation and repeat-associated translation in SCA31.2017
    • Author(s)
      Nagai Y., Ishikawa K.
    • Organizer
      2nd International symposium “Brain Protein Aging and Dementia Control”
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] 変異DNAJC13はエンドソーム輸送障害を介してαシヌクレイン神経毒性を増強する2017
    • Author(s)
      長谷川隆文、吉田隼、鈴木マリ、菅野直人、小林潤平、福田光則、藤林明美、関口清俊、江面道典、菊池昭夫、武田篤、望月秀樹、永井義隆、青木正志
    • Organizer
      第40回 日本神経科学会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Identification of target mRNA transported to axons by TDP-43.2017
    • Author(s)
      Nagano S., Ueyama M., Mochizuki H., Nagai Y., Araki T.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] リピート関連非ATG依存性翻訳の制御による筋委縮性側索硬化症の病態メカニズム解明2017
    • Author(s)
      永井義隆、上山盛夫
    • Organizer
      第40回 日本神経科学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Induction of exosome secretion and its proteomic changes in the polyglutamine disease models.2017
    • Author(s)
      Takeuchi T., Kanai M., Ueda K., Takafuji K., Sakai S., Nagai Y.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017) (
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Generation of transgenic monkey with tetracyclin-inducible gene expression system for neurodegenerative disease model.2017
    • Author(s)
      Tomioka I., Nogami N., Fujita N., Owari K., Nakatani T., Motohashi H., Takayama O., Nagai Y., Seki K.
    • Organizer
      The 4th World Congress of Reproductive Biology 2017 (WCRB 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] GBA機能喪失はα-シヌクレインの異常構造変化を促進して神経変性を悪化させる2017
    • Author(s)
      鈴木マリ、藤掛伸宏、武内敏秀、香山(古金谷)綾子、中嶋和紀、平林義雄、和田圭司、三五一憲、永井義隆
    • Organizer
      第36回 日本認知症学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] 中途覚醒の増加はアルツハイマー病モデルマウスのアミロイドβ病理を悪化させる2017
    • Author(s)
      皆川栄子、宮崎歴、丸尾和司、八木原紘子、藤田寛美、和田圭司、永井義隆
    • Organizer
      第36回 日本認知症学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] 遺伝子改変技術を用いた精神・神経疾患モデル霊長類の作出と評価2017
    • Author(s)
      関和彦、富岡郁夫、永井義隆、斎藤裕子、石橋英俊、花川隆、尾張健介、野上尚武、小泉昌司、皆川栄子、中谷輝美、川野邊哲代
    • Organizer
      第58回日本神経病理学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Identification of target mRNA transported to axons by TDP-43.2017
    • Author(s)
      Nagano S., Ueyama M., Mochizuki H., Nagai Y., Araki T.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] 中途覚醒の増加はアルツハイマー病モデルマウスのアミロイドβ病理を悪化させる2017
    • Author(s)
      皆川栄子、宮崎歴、丸尾和司、八木原紘子、藤田寛美、和田圭司、永井義隆
    • Organizer
      第36回 日本認知症学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Chronic sleep fragmentation accelerates amyloid β pathology in Alzheimer’s disease model mice.2017
    • Author(s)
      Minakawa E.N., Miyazaki K., Maruo K., Yagihara H., Fujita H., Wada K., Nagai Y.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] 中途覚醒の増加はアルツハイマー病モデルマウスのアミロイドβ病理を悪化させる2017
    • Author(s)
      皆川栄子、宮崎歴、丸尾和司、盆子原紘子、藤田寛美、和田圭司、永井義隆
    • Organizer
      第42回 日本睡眠学会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Dietary restriction improves neurodegeneration in Drosophila models of neurodegenerative diseases.2017
    • Author(s)
      Suzuki M., Neumann A.-M. Saitoh Y. Fujikake N., Wada K., Sango K., Nagai Y.
    • Organizer
      EMBO Symposium on Mechanisms of Neurodegeneration
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] p62/SQSTM1 contributes to the autophagic clearance of toxic protein oligomers in neurodegenerative diseases.2017
    • Author(s)
      Nagai Y., Saitoh Y.
    • Organizer
      The 8th International Symposium on Autophagy
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Repeat associated non-ATG translation and its regulation in C9orf72-associated amyotrophic lateral sclerosis/frontotemporal dementia model fly.2017
    • Author(s)
      Ueyama M., Ishiguro T., Konno T., Koyama A., Wada K., Ishikawa K., Onodera O., Nagai Y.
    • Organizer
      “PACTALS” and “Brain Protein Aging and Dementia Control” Project Joint Meeting
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Chronic sleep fragmentation accelerates amyloid β pathology in Alzheimer’s disease model mice.2017
    • Author(s)
      Minakawa E.N., Miyazaki K., Maruo K., Yagihara H., Fujita H., Wada K., Nagai Y.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] DNAJC13 mutation aggravates α SYN-induced neurotoxicity through alteration of endosomal trafficking.2017
    • Author(s)
      吉田隼、長谷川隆文、鈴木マリ、菅野直人、小林潤平、福田光則、藤林明美、関口清俊、江面道典、菊池昭夫、武田篤、望月秀樹、永井義隆、青木正志
    • Organizer
      第11回 パーキンソン病・運動障害疾患コングレス
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Regulatory role of RNA chaperone TDP-43 for RNA misfolding and repeat-associated translation in SCA31.2017
    • Author(s)
      Ishikawa K., Ishiguro T., Sato N., Ueyama M., Fujikake N., Sellier C., Tokuda E., Zamiri B., Gall-Duncan T., Mirceta M., Furukawa Y., Yokota T., Wada K., Taylor J.P., Pearson C.E., Charlet-Berguerand N., Mizusawa H., Nagai Y.
    • Organizer
      67th Annual Meeting of American Society of Human Genetics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] 遺伝子改変技術を用いた精神・神経疾患モデル霊長類の作出と評価2017
    • Author(s)
      関和彦、富岡郁夫、永井義隆、斎藤裕子、石橋英俊、花川隆、尾張健介、野上尚武、小泉昌司、皆川栄子、中谷輝美、川野邊哲代
    • Organizer
      第58回日本神経病理学会 (シンポジウム)
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] 変異DNAJC13はエンドソーム輸送障害を介してαシヌクレイン神経毒性を増強する2017
    • Author(s)
      長谷川隆文、吉田隼、鈴木マリ、菅野直人、小林潤平、福田光則、藤林明美、関口清俊、江面道典、菊池昭夫、武田篤、望月秀樹、永井義隆、青木正志
    • Organizer
      第40回 日本神経科学会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] 慢性的な中途覚醒の増加はアルツハイマー病モデルマウスのアミロイドβ病理を悪化させる2017
    • Author(s)
      皆川栄子、宮崎歴、丸尾和司、八木原紘子、藤田寛美、和田圭司、永井義隆
    • Organizer
      第12回 臨床ストレス応答学会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Transgenic monkey model of the polyglutamine diseases recapitulating progressive neurological symptoms and polyglutamine protein inclusions.2017
    • Author(s)
      Nagai Y., Tomioka I., Ishibashi H., Minakawa E.N, Motohashi H.H., Takayama O., Saito Y., Popiel H.A., Puentes S., Owari K., Nakatani T., Nogami N., Yamamoto K., Noguchi S., Nagano S., Nishino I., Ichinohe N., Wada K., Kohsaka S., Seki K.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Sleep abnormality as a novel candidate of modifiable risk factor for neurodegenerative diseases.2017
    • Author(s)
      Minakawa E.N., Nagai Y., Wada K.
    • Organizer
      Max Planck Institute& National Center of Neurology and Psychiatry Joint Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] The search for genes that modulate FUS-mediated phenotypes by Drosophila amyotrophic lateral sclerosis model.2017
    • Author(s)
      Azuma Y., Tokuda T., Kushimura Y., Yamamoto I., Ueoka I., Mizuta I., Mizuno T., Nakagawa M., Ueyama M., Nagai Y., Yoshida H., Yamaguchi M.
    • Organizer
      CSHL 2017 Neurobiology of Drosophila
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Improvement of misfolding protein-induced neurodegeneration by dietary restriction in Drosophila.2017
    • Author(s)
      Suzuki M., Neumann A.-M. Saitoh Y. Fujikake N., Wada K., Sango K., Nagai Y.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Regulatory role of TDP-43 as an RNA chaperone for RNA aggregation and repeat-associated translation in SCA31.2017
    • Author(s)
      Nagai Y., Ishikawa K.
    • Organizer
      2nd International symposium “Brain Protein Aging and Dementia Control”
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] 食餌制限は神経変性疾患モデルショウジョウバエの神経変性を改善する2017
    • Author(s)
      鈴木マリ、Anne-Marie Neumann、齊藤勇二、藤掛伸宏、和田圭司、三五一憲、永井義隆
    • Organizer
      第27回 病態生理学会大会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] 中途覚醒の増加はアルツハイマー病モデルマウスのアミロイドβ病理を悪化させる2017
    • Author(s)
      皆川栄子、宮崎歴、丸尾和司、盆子原紘子、藤田寛美、和田圭司、永井義隆
    • Organizer
      第42回 日本睡眠学会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Identification of target mRNA transported to axons by TDP-432017
    • Author(s)
      S. Nagano, M. Ueyama, Y. Nagai, H. Mochizuki, T. Araki
    • Organizer
      XXIII World Congress of Neurology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09690

  • [Presentation] Regulatory role of RNA chaperone for noncoding repeat RNA aggregation and repeat-associated translation in SCA31.2017
    • Author(s)
      Nagai Y., Ishiguro T., Sato N., Ueyama M., Fujikake N., Yokota T., Wada K., Mizusawa H., Ishikawa K.
    • Organizer
      The 43rd Naito Conference on Noncoding RNA：Biology, Chemistry, & Diseases
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Fine structural analysis of α-synuclein aggregates in patient’s brain with synchrotron radiation.2017
    • Author(s)
      Araki K., Yagi N., Ikenaka K., Hayakawa H., Baba K., Nagai Y., Mochizuki H.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] The search for genes that modulate FUS-mediated phenotypes by Drosophila amyotrophic lateral sclerosis model.2017
    • Author(s)
      Azuma Y., Tokuda T., Kushimura Y., Yamamoto I., Yoshida H., Mizuta I., Ueyama M., Nagai Y., Nakagawa M., Mizuno T., Yamaguchi M.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] 分子シャペロンはエクソソームを介した細胞間伝播によりポリグルタミン病に対して細胞非自律的な治療効果を発揮する2017
    • Author(s)
      永井義隆
    • Organizer
      第60回 日本神経化学会（シンポジウム）
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Induction of exosome secretion and its proteomic changes in the polyglutamine disease models.2017
    • Author(s)
      Takeuchi T., Kanai M., Ueda K., Takafuji K., Sakai S., Nagai Y.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] ter94機能喪失変異はTBPHノックダウンによるALSショウジョウバエモデルの表現型を増悪する2017
    • Author(s)
      櫛村由紀恵、徳田隆彦、東裕美子、山本格、上岡伊吹、水田依久子、水野 敏樹、中川正法、上山盛夫、永井義隆、吉田英樹、山口政光
    • Organizer
      第40回 日本分子生物学会・第90回 日本生化学会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Repeat associated non-ATG translation and its regulation in C9orf72-associated amyotrophic lateral sclerosis/frontotemporal dementia model fly.2017
    • Author(s)
      Ueyama M., Ishiguro T., Konno T., Koyama A., Wada K., Ishikawa K., Onodera O., Nagai Y.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] The search for genes that modulate FUS-mediated phenotypes by Drosophila amyotrophic lateral sclerosis model.2017
    • Author(s)
      東裕美子、徳田隆彦、櫛村由紀恵、山本格、上岡伊吹、吉田英樹、水田依久子、上山盛夫、永井義隆、中川正法、水野 敏樹、山口政光
    • Organizer
      第40回 日本分子生物学会・第90回 日本生化学会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Dietary restriction improves misfolding protein-related neurodegeneration in Drosophila.2017
    • Author(s)
      Suzuki M., Neumann A.-M. Saitoh Y. Fujikake N., Wada K., Sango K., Nagai Y.
    • Organizer
      Keystone Symposia on Aging and and Mechanisms of Aging-Related Disease
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Regulatory role of RNA chaperone TDP-43 for RNA misfolding and repeat-associated translation in SCA31.2017
    • Author(s)
      Ishikawa K., Ishiguro T., Sato N., Ueyama M., Fujikake N., Sellier C., Tokuda E., Zamiri B., Gall-Duncan T., Mirceta M., Furukawa Y., Yokota T., Wada K., Taylor J.P., Pearson C.E., Charlet-Berguerand N., Mizusawa H., Nagai Y.
    • Organizer
      67th Annual Meeting of American Society of Human Genetics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Improvement of misfolding protein-induced neurodegeneration by dietary restriction in Drosophila.2017
    • Author(s)
      Suzuki M., Neumann A.-M. Saitoh Y. Fujikake N., Wada K., Sango K., Nagai Y.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Fine structural analysis of α-synuclein aggregates in patient’s brain with synchrotron radiation.2017
    • Author(s)
      Araki K., Yagi N., Ikenaka K., Hayakawa H., Baba K., Nagai Y., Mochizuki H.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] ポリグルタミン病モデルマーモセットのライン化及び表現型解析2017
    • Author(s)
      野上尚武、尾張健介、中谷輝美、小泉昌司、佐賀洋介、川野邊哲代、永井義隆、富岡郁夫、関和彦
    • Organizer
      第40回 日本神経科学会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Repeat associated non-ATG translation and its regulation in C9orf72-associated amyotrophic lateral sclerosis/frontotemporal dementia model fly.2017
    • Author(s)
      Ueyama M., Ishiguro T., Konno T., Koyama A., Wada K., Ishikawa K., Onodera O., Nagai Y.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Elucidating the pathological mechanisms of amyotrophic lateral sclerosis/ frontotemporal dementia using Drosophila models.2017
    • Author(s)
      上山盛夫、永井義隆
    • Organizer
      第89回 日本遺伝学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] 分子シャペロンはエクソソームを介した細胞間伝播によりポリグルタミン病に対して細胞非自律的な治療効果を発揮する2017
    • Author(s)
      永井義隆
    • Organizer
      第60回 日本神経化学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] 食餌制限は神経変性疾患モデルショウジョウバエの神経変性を改善する2017
    • Author(s)
      鈴木マリ、Anne-Marie Neumann、齊藤勇二、藤掛伸宏、和田圭司、三五一憲、永井義隆
    • Organizer
      第27回 病態生理学会大会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Dietary restriction improves neurodegeneration in Drosophila models of neurodegenerative diseases.2017
    • Author(s)
      Suzuki M., Neumann A.-M. Saitoh Y. Fujikake N., Wada K., Sango K., Nagai Y.
    • Organizer
      EMBO Symposium on Mechanisms of Neurodegeneration
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] The search for genes that modulate FUS-mediated phenotypes by Drosophila amyotrophic lateral sclerosis model.2017
    • Author(s)
      Azuma Y., Tokuda T., Kushimura Y., Yamamoto I., Ueoka I., Mizuta I., Mizuno T., Nakagawa M., Ueyama M., Nagai Y., Yoshida H., Yamaguchi M.
    • Organizer
      CSHL 2017 Neurobiology of Drosophila
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Identification of target mRNA transported to axons by TDP-432017
    • Author(s)
      S. Nagano, M. Ueyama, Y. Nagai, H. Mochizuki, T. Araki
    • Organizer
      28th International Symposium on ALS/MND
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09690

  • [Presentation] DNAJC13 mutation aggravates α SYN-induced neurotoxicity through alteration of endosomal trafficking.2017
    • Author(s)
      吉田隼、長谷川隆文、鈴木マリ、菅野直人、小林潤平、福田光則、藤林明美、関口清俊、江面道典、菊池昭夫、武田篤、望月秀樹、永井義隆、青木正志
    • Organizer
      第11回 パーキンソン病・運動障害疾患コングレス
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Loss of function mutant of ter94, Drosophila VCP, partially enhanced motor neuron degeneration induced by knockdown of TBPH, Drosophila TDP-43.2017
    • Author(s)
      Kushimura Y., Tokuda T., Azuma Y., Yamamoto I., Ueoka I., Mizuta I., Mizuno T., Nakagawa M., Ueyama M., Nagai Y., Yoshida H., Yamaguchi M.
    • Organizer
      CSHL 2017 Neurobiology of Drosophila
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Dietary restriction improves misfolding protein-related neurodegeneration in Drosophila.2017
    • Author(s)
      Suzuki M., Neumann A.-M. Saitoh Y. Fujikake N., Wada K., Sango K., Nagai Y.
    • Organizer
      Keystone Symposia on Aging and and Mechanisms of Aging-Related Disease
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] 異常タンパク質の凝集・蓄積と神経変性疾患2017
    • Author(s)
      永井義隆
    • Organizer
      第25回 日本神経学会近畿地区生涯教育講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Balance between RNA binding proetin TDP-43 and an RNA UGGAA repeat underlies pathogenesis of spinocerebellar ataxia type 31 (SCA31) and motor neuron disease fly models.2017
    • Author(s)
      Ishiguro T., Sato N., Ueyama M., Fujikake N., Sellier C., Tokuda E., Zamiri B., Gall-Duncan T., Mirceta M., Furukawa Y., Yokota T., Wada K., Taylor J.P., Pearson C.E., Charlet-Berguerand N., Mizusawa H., Nagai Y., Ishikawa K.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] 中途覚醒の増加はアルツハイマー病モデルマウスのアミロイドβ病理を悪化させる2017
    • Author(s)
      皆川栄子、宮崎歴、丸尾和司、盆子原紘子、藤田寛美、和田圭司、永井義隆
    • Organizer
      第40回 日本神経科学会
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] In vitro assessment of extracellular α-synuclein secretion.2017
    • Author(s)
      Hayakawa H., Baba K., Takeuchi T., Choong C.J., Nagano S., Nagai Y., Hagihara K., Mochizuki H.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19658

  • [Presentation] Parkinson’s disease-linked DNAJC13 mutation aggravates α-synuclein-induced neurotoxicity through perturbation of endosomal trafficking.2017
    • Author(s)
      Hasegawa T., Yoshida S., Suzuki M., Sugeno N., Kobayashi J., Ueyama M., Ezura M., Kikuchi A., Baba T., Takeda A., Mochizuki H., Nagai Y., Aoki M.
    • Organizer
      The 23rd World Congress of Neurology (WCN 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] The functional analysis of TDP-43 by Drosophila ALS model.2016
    • Author(s)
      櫛村由紀恵、徳田隆彦、東裕美子、山本格、京谷茜、吉田英樹、吉田誠克、水田依久子、上山盛夫、永井義隆、中川正法、水野俊樹、山口政光
    • Organizer
      第57回 日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] 培養細胞系を用いたαシヌクレインの凝集阻害因子の検討2016
    • Author(s)
      薮本大紀、池中建介、仲谷利栄、上原拓也、堺竜介、Choong Chi-Jing、蒋詩桜、早川英規、馬場孝輔、長野清一、永井義隆、望月秀樹
    • Organizer
      第10回 パーキンソン病・運動障害疾患コングレス
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] The functional analysis of TDP-43 by Drosophila ALS model. 第39回 日本分子生物学会（H28.11.30-12.2、横浜）2016
    • Author(s)
      櫛村由紀恵、徳田隆彦、東裕美子、山本格、中村綾、奥主隆太、上岡伊吹、京谷茜、吉田英樹、水田依久子、上山盛夫、永井義隆、中川正法、水野俊樹、山口政光
    • Organizer
      第39回 日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Parkinson’s disease-linked mutation in DNAJC13 causes specific trafficking defect in endosomal pathway2016
    • Author(s)
      吉田隼、長谷川隆文、鈴木マリ、小林潤平、大嶋龍児、菅野直人、菊池昭夫、武田篤、永井義隆、青木正志
    • Organizer
      第39回 日本神経科学会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] QAI1, a polyglutamine protein oligomerization inhibitor, exerts disease-modifying therapeutic effect.2016
    • Author(s)
      皆川栄子、ポピエルヘレナ明子、他田正義、高橋俊昭、山根宏志、斉藤勇二、鈴木マリ、岡本佑馬、渡瀬啓、足立弘明、勝野雅央、祖父江元、戸田達史、和田圭司、小野寺理、永井義隆
    • Organizer
      第57回 日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Screening for polyglutamine aggregation inhibitors that suppress neurodegeneration in fly models.2016
    • Author(s)
      斉藤勇二、岡本佑馬、ポピエル明子、藤掛伸宏、戸田達史、和田圭司、永井義隆
    • Organizer
      第57回 日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] FUS regulates synapse structure and function at the neuromuscular junctions by Drosophila ALS model.2016
    • Author(s)
      東裕美子、徳田隆彦、櫛村由紀恵、山本格、中村綾、水田依久子、上山盛夫、永井義隆、中川正法、水野俊樹、吉田英樹、山口政光
    • Organizer
      第39回 日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] エクソソームを介した分子シャペロンの細胞間伝播によりポリグルタミン病モデルショウジョウバエに対して細胞非自律的な治療効果を発揮する2016
    • Author(s)
      永井義隆
    • Organizer
      第68回 日本細胞生物学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] C9ALS/FTDモデルショウジョウバエにおけるジペプチドリピートタンパク質の毒性2016
    • Author(s)
      上山盛夫、石黒太郎、Gendron T.F.、藤掛伸宏、今野卓哉、小山哲秀、小野寺理、石川欽也、和田圭司、Petrucelli L.、永井義隆
    • Organizer
      第88回 日本遺伝学会大会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] グルコセレブロシダーゼ機能欠失はαシヌクレインの異常構造変化を促進して神経変性を増悪する2016
    • Author(s)
      鈴木マリ、藤掛伸宏、武内敏秀、香山(古金谷)綾子、中嶋和紀、平林義雄、和田圭司、永井義隆
    • Organizer
      第10回 パーキンソン病・運動障害疾患コングレス
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Neurotoxicity of TDP-43 is linked to axonal dysfunction of ribosomal proteins2016
    • Author(s)
      Nagano S, Ueyama M, Wada K, Nagai Y, Araki T.
    • Organizer
      第35回日本認知症学会学術集会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2016-12-01
    • Data Source
      KAKENHI-PROJECT-16K09690

  • [Presentation] 神経変性疾患における血中エクソソームを利用したバイオマーカーの探索2016
    • Author(s)
      金井雅裕、武内敏秀、鈴木マリ、藤田寛美、植田幸嗣、永井義隆
    • Organizer
      第8回 日本RNAi研究会/第3回 日本細胞外小胞学会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Generation of transgenic marmoset line with polyglutamine disease and behavioral phenotyping.2016
    • Author(s)
      K Owari, N Nogami, T Nakatani, M Koizumi, H Ishibashi, Y Nagai, I Tomioka, K Seki.
    • Organizer
      Society for Neuroscience 46th annual meeting
    • Place of Presentation
      San Diego convention center, San Diego, USA
    • Year and Date
      2016-11-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26870884

  • [Presentation] Identification of target mRNA transported to axons by TDP-43.2016
    • Author(s)
      Nagano S., Ueyama M., Wada K., Nagai Y., Araki T.
    • Organizer
      4th RNA Metabolism in Neurological Disease Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] エクソソームを介した細胞非自律的タンパク質恒常性維持機構2016
    • Author(s)
      武内敏秀、永井義隆
    • Organizer
      第14回 神経科学研究会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Intercellular transmission of molecular chaperones via exosomes contributes to maintenance of organismal protein homeostasis.2016
    • Author(s)
      Takeuchi T., Suzuki M., Fujikake N., Popiel H.A., Kikuchi H., Sakai S., Futaki S., Wada K., Nagai Y.
    • Organizer
      2016 CSH Asia meeting: Biology & Function of Extracellular Vesicles: Exosomes, Microvesicles & Beyond
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] SCA3マーモセットモデルの作出2016
    • Author(s)
      富岡郁夫、石橋英俊、本橋秀之、高山修、皆川栄子、齊藤祐子、皆川栄子、ポピエル明子、プエンテスサンドラ、山本和弘、野口悟、藤田尚子、尾張健介、中谷輝美、西野一三、和田圭司、高坂新一、永井義隆、関和彦
    • Organizer
      第57回 日本神経学会学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] 過栄養食が神経変性疾患モデルショウジョウバエの神経変性を増悪する分子メカニズムの探索2016
    • Author(s)
      鈴木マリ、Anne-Marie Neumann、斉藤勇二、藤掛伸宏、和田圭司、永井義隆
    • Organizer
      第38回日本生物学的精神医学会・第59回日本神経化学会大会合同年会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] シヌクレイン凝集阻害薬の大規模スクリーニング系の開発2016
    • Author(s)
      池中建介、荒木克哉、薮本大紀、Choong Chi-Jing、早川英規、宗正智、馬場孝輔、橋本真一、長野清一、永井義隆、後藤祐児、望月秀樹
    • Organizer
      第10回 パーキンソン病・運動障害疾患コングレス
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Neuronal toxicity of TDP-43 is associated with the dysfunction of ribosomal proteins in axons2016
    • Author(s)
      Nagano S, Ueyama M, Wada K, Nagai Y, Saito Y, Araki T.
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター、神戸ポートピアホテル
    • Year and Date
      2016-05-18
    • Data Source
      KAKENHI-PROJECT-16K09690

  • [Presentation] Elucidating molecular pathomechanisms of C9-linked ALS/FTD using Drosophila models.2016
    • Author(s)
      Nagai Y., Ueyama M., Ishiguro T., Onodera O., Ishikawa K., Wada K., Petrucelli L.
    • Organizer
      International Asidan Symposium 2016
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Toxicity of dipeptide repeat proteins in C9 ALS/FTD model fly.2016
    • Author(s)
      Ueyama M., Ishiguro T., Gendron T.F., Fujikake N., Konno T., Koyama A., Onodera O., Ishikawa K., Wada K., Petrucelli L., Nagai Y.
    • Organizer
      4th RNA Metabolism in Neurological Disease Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] 家族性パーキンソン病PARK21の分子病態解析2016
    • Author(s)
      吉田隼、長谷川隆文、鈴木マリ、小林潤平、大嶋龍児、菅野直人、菊池昭夫、武田篤、永井義隆、青木正志
    • Organizer
      第14回 神経科学研究会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] 放射光赤外分光法を用いた剖検脳のグリア細胞内嗜銀性封入体の構造解析2016
    • Author(s)
      荒木克哉、八木直人、池中建介、早川英規、永井義隆、藤村晴俊、望月秀樹
    • Organizer
      第10回 パーキンソン病・運動障害疾患コングレス
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] パーキンソン病リスク遺伝子GBAの機能喪失はα-シヌクレインの異常構造変化を促進して神経変性を悪化させる2016
    • Author(s)
      鈴木マリ、藤掛伸宏、武内敏秀、香山(古金谷)綾子、中嶋和紀、平林義雄、和田圭司、永井義隆
    • Organizer
      第26回 病態生理学会大会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Neuronal toxicity of TDP-43 is associated with the dysfunction of ribosomal proteins in axons.2016
    • Author(s)
      長野清一、上山盛夫、和田圭司、永井義隆、齊藤祐子、荒木敏之
    • Organizer
      第57回 日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] シャペロンのエクソソーム分泌による細胞非自律的プロテオスタシス調節機構2016
    • Author(s)
      武内敏秀、永井義隆
    • Organizer
      第89回 日本生化学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] ショウジョウバエC9ALS/FTDモデルにおけるリピート関連非ATG翻訳2016
    • Author(s)
      上山盛夫、石黒太郎、藤掛伸宏、今野卓哉、小山哲秀、小野寺理、和田圭司、永井義隆
    • Organizer
      第57回 日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] ショウジョウバエモデルを用いた神経変性疾患研究2016
    • Author(s)
      永井義隆
    • Organizer
      第57回 日本神経学会学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Hsp70の機能欠損体が示す細胞非自律的な変性抑制効果2016
    • Author(s)
      武内敏秀、鈴木マリ、坂井聖子、二木史朗、和田圭司、永井義隆
    • Organizer
      第8回 日本RNAi研究会/第3回 日本細胞外小胞学会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Non-cell autonomous therapeutic effects on polyQ disease models by exosomal chaperone transmission.2016
    • Author(s)
      武内敏秀、鈴木マリ、藤掛伸宏、ポピエル明子、菊地寿枝、二木史朗、和田圭司、永井義隆
    • Organizer
      第57回 日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Identification of target mRNA transported to axons by TDP-432016
    • Author(s)
      Nagano S, Ueyama M, Wada K, Nagai Y, Araki T.
    • Organizer
      11th Brain Research Conference
    • Place of Presentation
      Paradise Point, San Diego, USA
    • Year and Date
      2016-11-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09690

  • [Presentation] GBA deficiency accelerates α-synuclein prion-like conversion and promotes its neurotoxicity.2016
    • Author(s)
      鈴木マリ、藤掛伸宏、武内敏秀、香山(古金谷)綾子、中嶋和紀、平林義雄、和田圭司、永井義隆
    • Organizer
      第57回 日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-16H05325

  • [Presentation] Exome association study and 2nd SNP-GWAS of Parkinson's disease2015
    • Author(s)
      佐竹渉、安藤祐子、鈴木マリ、富山弘幸、永井義隆、村山繁雄、望月秀樹、中島健二、小幡文弥、長谷川一子、武田篤、和田圭司、辻省次、山本光利、村田美穂、服部信孝、戸田達史
    • Organizer
      第56回 日本神経学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-20
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] Establishment of a novel animal model of ALS/FTD expressing GGGGCC repeat RNA in Drosophila2015
    • Author(s)
      Ueyama M., Ishiguro T., Fujikake N., Konno T., Koyama A., Onodera O., Ishikawa K., Wada K., Nagai Y.
    • Organizer
      10th Brain Research Conference
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2015-10-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] The SCA31-linked UGGAAexp repeat forms RNA foci and is translated into aggregating pentapeptide-repeat proteins in the SCA31 patient brain and Drosophila model.2015
    • Author(s)
      Ishiguro T., Sato N., Fujikake N., Ueyama M., Yokota T., Mizusawa H., Wada K., Nagai Y., Ishikawa K.
    • Organizer
      10th Brain Research Conference
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2015-10-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] 異常伸長UGGAA リピートRNAはショウジョウバエにおいて神経毒性を引き起こす2015
    • Author(s)
      石黒太郎、藤掛伸宏、佐藤望、上山盛夫、横田隆徳、和田圭司、水澤英洋、永井義隆、石川 欽也
    • Organizer
      第38回 日本神経科学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] p62 plays a protective role in neurodegenerative diseases model flies2015
    • Author(s)
      斉藤勇二、藤掛伸宏、岡本佑馬、和田圭司、永井義隆
    • Organizer
      第56回 日本神経学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-20
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] Effect of dietary conditions on Drosophila models of neurodegenerative diseases2015
    • Author(s)
      鈴木マリ、Anne-Marie Neumann、斉藤勇二、藤掛伸宏、和田圭司、永井義隆
    • Organizer
      第56回 日本神経学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-20
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] SCA31-linked UGGAAexp RNA causes progressive neurodegeneration in Drosophila.2015
    • Author(s)
      石黒太郎、藤掛伸宏、佐藤望、上山盛夫、横田隆徳、和田圭司、水澤英洋、永井義隆、石川欽也
    • Organizer
      第56回 日本神経学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-20
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] Establishment of a novel animal model of ALS and FTD expressing GGGGCC repeat RNA in Drosophila2015
    • Author(s)
      上山盛夫、石黒太郎、藤掛伸宏、今野卓哉、小山哲秀、小野寺理、石川欽也、和田圭司、永井義隆
    • Organizer
      第38回 日本神経科学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] ポリグルタミン病トランスジェニックマーモセットの樹立2015
    • Author(s)
      永井義隆、富岡郁夫、石橋英俊、本橋秀之、高山修、齊藤祐子、皆川栄子、ポピエル明子、プエンテスサンドラ、山本和弘、野口悟、西野一三、和田圭司、高坂新一、関和彦
    • Organizer
      第56回 日本神経学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-20
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] 分子シャペロンのエクソソームを介した細胞間伝播による細胞非自律的なタンパク質の恒常性維持機構2015
    • Author(s)
      武内敏秀、鈴木マリ、藤掛伸宏、ポピエル明子、菊地寿枝、二木史朗、和田圭司、永井義隆
    • Organizer
      第10回 臨床ストレス応答学会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-06
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] 分子シャペロンはエクソソーム細胞間伝播により細胞非自律的な治療効果を発揮する2015
    • Author(s)
      武内敏秀、永井義隆
    • Organizer
      第34回 日本認知症学会学術集会
    • Place of Presentation
      青森
    • Year and Date
      2015-10-02
    • Invited
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] Toxic protein conformational transition and aggregation as a therapeutic target for the polyglutamine neurodegenerative diseases.2015
    • Author(s)
      Nagai Y.
    • Organizer
      Cajal Institute seminar
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2015-04-20
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] Non-cell autonomous therapeutic effects of molecular chaperones on polyglutamine disease models via its exosome-mediated intercellular transmission.2015
    • Author(s)
      Nagai Y., Takeuchi T., Wada K.
    • Organizer
      IWBBIO 2015
    • Place of Presentation
      Granada, Spain
    • Year and Date
      2015-04-15
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] Identification of genes modulating TDP-43 by Drosophila ALS model2015
    • Author(s)
      東裕美子、徳田隆彦、山本格、京谷茜、櫛村由紀恵、吉田誠克、水田依久子、水野俊樹、中川正法、藤掛伸宏、上山盛夫、永井義隆、吉田英樹、山口政光
    • Organizer
      第56回 日本神経学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-20
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] 神経変性疾患モデルショウジョウバエの神経変性は過栄養摂取により増悪する2015
    • Author(s)
      永井義隆、鈴木マリ、Anne-Marie Neumann、藤掛伸宏、和田圭司
    • Organizer
      第34回 日本認知症学会学術集会
    • Place of Presentation
      青森
    • Year and Date
      2015-10-02
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] 神経変性疾患におけるRNA chaperoneの働き：RNA quality controlの観点から2015
    • Author(s)
      石黒太郎、横田隆徳、永井義隆、石川欽也
    • Organizer
      第10回 臨床ストレス応答学会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-06
    • Invited
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] Intercellular chaperone transmission via exosomes contributes to non-cell autonomous therapeutic effects on polyglutamine disease models2015
    • Author(s)
      武内敏秀、鈴木マリ、藤掛伸宏、ポピエル明子、菊地寿枝、二木史朗、和田圭司、永井義隆
    • Organizer
      第38回 日本神経科学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] G4C2リピートRNAを発現する新規ALS/FTDモデルショウジョウバエの樹立2015
    • Author(s)
      上山盛夫、石黒太郎、藤掛伸宏、今野卓哉、小山哲秀、小野寺理、石川欽也、和田圭司、永井義隆
    • Organizer
      第87回 日本遺伝学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2015-09-24
    • Invited
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] 分子シャペロンはエクソソームを介した細胞間伝播により個体レベルのプロテオスターシス維持に寄与している2015
    • Author(s)
      武内敏秀、鈴木マリ、藤掛伸宏、ポピエル明子、菊地寿枝、二木史朗、和田圭司、永井義隆
    • Organizer
      第7回 日本RNAi研究会/第2回 日本細胞外小胞学会
    • Place of Presentation
      広島
    • Year and Date
      2015-08-26
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] TDP-43のオリゴマー化・神経変性メカニズムの解明2014
    • Author(s)
      永井義隆
    • Organizer
      平成26年度厚労省「筋萎縮性側索硬化症の新規治療法・病態解明研究班」ワークショップ
    • Place of Presentation
      東京
    • Year and Date
      2014-09-26
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-25110741

  • [Presentation] In vivoイメージングによって見えてきた神経変性疾患の発達障害としての側面2014
    • Author(s)
      畑中悠佑、渡瀬啓、和田圭司、永井義隆
    • Organizer
      第12回神経科学研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-25
    • Data Source
      KAKENHI-PUBLICLY-25110741

  • [Presentation] 蛋白質のミスフォールディング・凝集を標的とした神経変性疾患の治療戦略－ポリグルタミン病をモデルとして2014
    • Author(s)
      永井義隆
    • Organizer
      京都大学薬学系研究科大学院講義
    • Place of Presentation
      京都
    • Year and Date
      2014-05-27
    • Invited
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] 分子シャペロンによるポリグルタミンタンパク質の品質管理機構2014
    • Author(s)
      永井義隆
    • Organizer
      奈良先端大学院大学セミナー
    • Place of Presentation
      奈良
    • Year and Date
      2014-11-12
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-25110741

  • [Presentation] TDP-43のオリゴマー化・神経変性メカニズムの解明2014
    • Author(s)
      永井義隆
    • Organizer
      平成26年度厚労省「筋萎縮性側索硬化症の新規治療法・病態解明研究班」ワークショップ
    • Place of Presentation
      東京
    • Year and Date
      2014-09-26
    • Invited
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] ショウジョウバエモデルを用いた神経変性疾患の病態解明・治療法開発～ALSモデルを中心に～2014
    • Author(s)
      永井義隆
    • Organizer
      第32回 Neuroscience Seminar Tokushima
    • Place of Presentation
      徳島
    • Year and Date
      2014-09-01
    • Invited
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] ポリグルタミン蛋白質の凝集・細胞毒性獲得メカニズム2014
    • Author(s)
      永井義隆
    • Organizer
      タウ研究ミーティング
    • Place of Presentation
      東京
    • Year and Date
      2014-08-01
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-25110741

  • [Presentation] ショウジョウバエモデルを用いた神経変性疾患の病態解明・治療法開発～ALSモデルを中心に～2014
    • Author(s)
      永井義隆
    • Organizer
      第32回 Neuroscience Seminar Tokushima
    • Place of Presentation
      徳島
    • Year and Date
      2014-09-01
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-25110741

  • [Presentation] Oligomerization of TDP-43 is triggered by imbalance of microtubule-dependent transport, leading to neurodegeneration.2014
    • Author(s)
      Nagai Y.
    • Organizer
      International symposium "New frontier of molecular neuropathology 2014"
    • Place of Presentation
      Tokyo, Japan
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-25110741

  • [Presentation] Oligomerization of TDP-43 is triggered by imbalance of microtubule-dependent transport2014
    • Author(s)
      Nagai Y.
    • Organizer
      leading to neurodegeneration Int Symp"New frontier of molecular neuropathology 2014"
    • Place of Presentation
      Tokyo, Japan
    • Data Source
      KAKENHI-PROJECT-24659438

  • [Presentation] In vivoイメージングによって見えてきた神経変性疾患の発達障害としての側面2014
    • Author(s)
      畑中悠佑、渡瀬啓、和田圭司、永井義隆
    • Organizer
      第12回神経科学研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-25
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] 神経変性疾患に対する蛋白質ミスフォールディング・凝集を標的とした治療戦略－ポリグルタミン病をモデルとして2014
    • Author(s)
      永井義隆
    • Organizer
      第9回青森神経科学談話会
    • Place of Presentation
      青森
    • Year and Date
      2014-06-14
    • Invited
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] Oligomerization of TDP-43 is triggered by imbalance of microtubule-dependent transport, leading to neurodegeneration.2014
    • Author(s)
      Nagai Y.
    • Organizer
      International symposium "New frontier of molecular neuropathology 2014"
    • Place of Presentation
      Tokyo, Japan
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390237

  • [Presentation] Oligomerization of TDP-43 is triggered by imbalance of microtubule-dependent transport, leading to neurodegeneration2014
    • Author(s)
      Nagai Y
    • Organizer
      Int Symp "New frontier of molecular neuropathology 2014"
    • Place of Presentation
      Tokyo, Japan
    • Data Source
      KAKENHI-PROJECT-23390237

  • [Presentation] リグルタミン蛋白質の凝集・細胞毒性獲得メカニズム2014
    • Author(s)
      永井義隆
    • Organizer
      タウ研究ミーティング
    • Place of Presentation
      東京
    • Year and Date
      2014-08-01
    • Invited
    • Data Source
      KAKENHI-PROJECT-26670446

  • [Presentation] 神経変性疾患に対する蛋白質ミスフォールディング・凝集を標的とした治療戦略－ポリグルタミン病をモデルとして2014
    • Author(s)
      永井義隆
    • Organizer
      第9回青森神経科学談話会
    • Place of Presentation
      青森
    • Year and Date
      2014-06-14
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-25110741

  • [Presentation] Oligomerization of TDP-43 is triggered by imbalance of microtubule-dependent transport, leading to neurodegeneration.2014
    • Author(s)
      Nagai Y.
    • Organizer
      International symposium "New frontier of molecular neuropathology 2014"
    • Place of Presentation
      Tokyo, Japan
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659438

  • [Presentation] 分子シャペロンによるポリグルタミンタンパク質の品質管理機構2014
    • Author(s)
      永井義隆
    • Organizer
      奈良先端大学院大学セミナー
    • Place of Presentation
      奈良
    • Year and Date
      2014-11-12
    • Invited
    • Data Source
      KAKENHI-PROJECT-26670446

  • [P