akiyama haruhiko 秋山治彦

… Alternative Names

AKIYAMA Haruhiko 秋山治彦

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Researcher Number	20231839
Other IDs
External Links
Affiliation (Current)	2025: 横浜市立脳卒中・神経脊椎センター(臨床研究部), 臨床研究部, 臨床研究部長
Affiliation (based on the past Project Information) *help	2016 – 2017: 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 研究員 2014 – 2015: 公益財団法人東京都医学総合研究所, 知的財産活用センター, 分野長 2014 – 2015: 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 参事研究員 2012 – 2014: 公益財団法人東京都医学総合研究所, 認知症・高次脳機能分野, 参事研究員 2012: 公益財団法人東京都医学総合研究所, 認知症.高次脳機能研究分野, 参事研究員 … More 2011: 財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 参事研究員 2010: 財団法人東京都医学研究機構, 東京都精神医学総合研究所, 参事研究員 2009: Tokyo Metropolitan Organization for Medical Research, 東京都精神医学総合研究所, 参事研究員 2005: Tokyo Metropolitan Organization for Medical Research, Tokyo Institute of Psychiatry, Research Director, 東京都精神医学総合研究所, 参事研究員 2004: 財団法人東京都医学研究機構, 東京都精神医学総合研究所, 参事研究員 2000: 財団法人東京都医学研究機構, 東京都精神医学総合研究所, 副参事研究員 1999 – 2000: 財団法人東京都医学研究機構, 東京都精神医学総合研究所, 副参事研究員 1998: 財団法人東京都精神医学総合研究所, 神経病理研究部門, 副参事研究員 1997: Tokyo Institute of Psychiatry, Department of Neuropathology, Section Head, 神経病理研究部門, 副参事研究員 1993 – 1997: (財)東京都精神医学総合研究所, 神経病理研究部門, 副参事研究員 Less
Review Section/Research Field	Principal Investigator Neurology / Psychiatric science / Nerve anatomy/Neuropathology / Psychiatric science Except Principal Investigator Psychiatric science / Neurology / Biological Sciences
Keywords	Principal Investigator アルツハイマー病 / Alzheimer's disease / microglia / ミクログリア / アミロイドβ蛋白 / アミロイドβ蛋白質 / タウ / 認知症 / Lewy body disease / Hallucination and Delusion … More / Psychiatric symptoms / 痴呆 / アルツハイマー型痴呆 / 神経原線維変化型痴呆 / 後部帯状回 / 神経原線維変化 / レヴィー小体病 / 幻覚・妄想 / 精神症状 / Aβ-processing / amyloid β-protein / Aβプロセッシング / metabolism / phagocytosis / amyloid beta-protein / エピトープ / 抗体 / 分解処理 / アストロサイト / 代謝 / 貪食 / the blood coagulation system / thrombin / 凝固系 / トロンビン / 異常蛋白蓄積 / 伝播 / 異常蓄積蛋白 / 病理 / 前頭側頭葉変性症 / FUS / TDP-43 / グラニュリン / プロテイノパチー / 老年精神医学 … More Except Principal Investigator 前頭側頭葉変性症 / タウ / TDP-43 / 神経原線維変化 / アルツハイマー病 / 認知症 / RNA代謝 / 神経変性 / 筋委縮性側索硬化症 / 筋萎縮性側索硬化症 / 神経変性疾患 / タンパク質凝集体 / 凝集体形成 / FUS / 凝集体 / RNA metabolism / 神経原線維型認知症 / 側坐核 / 線条体 / 伝播 / 神経原線維変化型老年期認知症 / 蛋白脱リン酸化酵素 / 蛋白リン酸化酵素 / タウ蛋白 / 細胞内シグナル伝達 / 細胞周期 / 神経細胞変性 / 国際情報交換（カナダ） / 免疫組織化学 / 脳 / リン酸化 / 細胞周期調節 / アルツハイマー型認知症 / トランスジェニックマウス / プログラニュリン / グラニュリン / タンパク質異常凝集 / 疾患モデルマウス / tau / 細胞死 / 酸化ストレス / ストレス顆粒 / 前頭側頭型認知症 / 神経科学 / ロイペプチン / アストロサイト / リソゾーム Less

The mechanism of tau accumulation in the striatum of tauopathy
- Principal Investigator
  
  KAWAKAMI Ito
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Investigation of protein-RNA interaction implicated in neurodegeneration
- Principal Investigator
  
  Higashi Shinji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  University of Tsukuba
タウ蛋白リン酸化シグナル巨大複合体を介する変性認知症の神経細胞死に関する病態解析
- Principal Investigator
  
  川又敏男
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kobe University
Pathological study of abnormal protein accumulation and its propagation in the brain of patients with dementiaPrincipal Investigator
- Principal Investigator
  
  AKIYAMA Haruhiko
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Creation of novel model mice for dementia research and development of new medicines for dementia treatment.
- Principal Investigator
  
  HOSOKAWA Masato
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Investigation of effect of TDP-43 aggregation on translational control
- Principal Investigator
  
  HIGASHI Shinji
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  公益財団法人東京都医学総合研究所
   Tokyo Metropolitan Organization for Medical Research
Experimental research on the pathogenesis and pathophysiology of diseases that cause dementiaPrincipal Investigator
- Principal Investigator
  
  AKIYAMA Haruhiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  財団法人東京都医学総合研究所
   Tokyo Metropolitan Organization for Medical Research
Psychiatric symptoms as preceding or early signs of dementia of Alzheimer type. A cohort study.Principal Investigator
- Principal Investigator
  
  AKIYAMA Haruhiko, 池田研二
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
タウ蛋白異常疾患脳におけるタウの代謝・処理過程の研究
- Principal Investigator
  
  ARAI Tetsuaki
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Investigation on the amyloid β-protein (Aβ)20231839Principal Investigator
- Principal Investigator
  
  AKIYAMA Haruhiko
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tokyo Metropolitan Organization of Medical Research
  Tokyo Institute of Psychiatry
Phagocytosis and degradation of amyloid beta-protein by microglia in the brain of Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  AKIYAMA Haruhiko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tokyo Institute of Psychiatry
The mechanism of thrombin deposition in Alzheimer's disease senile plaques and its pathological significancePrincipal Investigator
- Principal Investigator
  
  AKIYAMA Haruhiko
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tokyo Institute of Psychiatry

All 2017 2016 2015 2014 2013 2012 2011 2010 2009 2006 2005 2004 2003 Other

All Journal Article Presentation Book

[Book] Progress in Alzheimer's and Parkinson's; Diseases (Edited by I. Hanim, R. Cacabelos & A. Fisher)2005
- Author(s)
  Akiyama H, et al.
- Publisher
  Taylor & Francis, London
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570957
[Book] Progress in Alzheimer's and Parkinson's ; Diseases(Edited by I.Hanim, R.Cacabelos & A.Fisher)2005
- Author(s)
  Akiyama H, et al.
- Publisher
  Taylor & Francis, London
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] Frontotemporal dementia with trans-activation response DNA-binding protein 13 presenting with cartatonic syndrome.2017
- Author(s)
  Watanabe R, Kawakami I, Onaya M, Higashi S, Arai N, Akiyama H, Hasegawa M, Arai T
- Journal Title
  
  Neuropathology
  
  Volume: 印刷中 Issue: 3 Pages: 281-287
- DOI
  10.1111/neup.12442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09822, KAKENHI-PLANNED-26117005
[Journal Article] <その他の変性疾患の病理と精神症状>tangle-predominant dementia（神経原線維変化型老年期認知症）の臨床病理学的特徴2016
- Author(s)
  河上　緒，新井哲明，秋山治彦
- Journal Title
  
  老年精神医学雑誌
  
  Volume: 27(1) Pages: 75-80
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19757
[Journal Article] Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43.2016
- Author(s)
  Nonaka T, Suzuki G, Tanaka Y, Kametani F, Hirai S, Okado H, Miyashita T, Saitoe M, Akiyama H, Masai H, Hasegawa M.
- Journal Title
  
  The journal of Biological Chemistry
  
  Volume: 291 Issue: 11 Pages: 5473-83
- DOI
  10.1074/jbc.m115.695379
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18370, KAKENHI-PROJECT-221S0003, KAKENHI-ORGANIZER-25115001, KAKENHI-PLANNED-25115006, KAKENHI-PROJECT-23228004, KAKENHI-PROJECT-25250010, KAKENHI-PROJECT-14J03307, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-25650014, KAKENHI-PROJECT-26251004, KAKENHI-PROJECT-26290016, KAKENHI-PROJECT-16K14569, KAKENHI-PROJECT-16K14675
[Journal Article] Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau.2016
- Author(s)
  Taniguchi-Watanabe S, Arai T, Kametani F, Nonaka T, Masuda-Suzukake M, Tarutani A, Murayama S, Saito Y, Arima K, Yoshida M, Akiyama H, Robinson A, Mann DM, Iwatsubo T, Hasegawa M.
- Journal Title
  
  Acta Neuropathol.
  
  Volume: 131(2) Issue: 2 Pages: 267-280
- DOI
  10.1007/s00401-015-1503-3
- NAID
  120007128537
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461733, KAKENHI-PUBLICLY-26111730, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-16H06277
[Journal Article] A family with hereditary diffuse leukoencephalopathy with spheroids caused by a novel c.2442+2T>C mutation in the CSF1R gene.2016
- Author(s)
  Kawakami I, Iseki E, Kasanuki K, Minegishi M, Sato K, Hino H, Shibuya K, Fujisawa K, Higashi S, Akiyama H, Furuta A, Takanashi M, Li Y, Hattori N, Mitsuyama Y, Arai H.
- Journal Title
  
  Journal of Neuroogicall Science
  
  Volume: 15;367 Pages: 349-55
- DOI
  10.1016/j.jns.2016.06.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19757, KAKENHI-PROJECT-15K09822, KAKENHI-PROJECT-16K09700
[Journal Article] Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration.2016
- Author(s)
  Kawakami I, Kobayashi Z, Arai T, Yokota O, Nonaka T, Aoki N, Niizato K, Oshima K, Higashi S, Katsuse O, Hosokawa M, Hasegawa M, Akiyama H.
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: 4 Issue: 1 Pages: 36-36
- DOI
  10.1186/s40478-016-0304-9
- NAID
  120007135517
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09822, KAKENHI-PROJECT-15K09850, KAKENHI-PUBLICLY-26111730, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-26461733, KAKENHI-PROJECT-15K19757, KAKENHI-PROJECT-26461752
[Journal Article] The Abundance of Nonphosphorylated Tau in Mouse and Human Tauopathy Brains Revealed by the Use of Phos-Tag Method2016
- Author(s)
  Kimura T, Hatsuta H, Masuda-Suzukake M, Hosokawa M, Ishiguro K, Akiyama H, Murayama S, Hasegawa M, Hisanaga S
- Journal Title
  
  American Journal of Pathology
  
  Volume: 186 Issue: 2 Pages: 398-409
- DOI
  10.1016/j.ajpath.2015.10.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09850, KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-26117004, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-25290024, KAKENHI-PROJECT-16K07060, KAKENHI-PROJECT-16H06277
[Journal Article] Progranulin reduction is associated with tau phosphorylation in P301L tau transgenic mice2015
- Author(s)
  Hosokawa M, Arai T, Masuda-Suzukake M, Kondo H, Matsuwaki T, Nishihara M, Hasegawa M, Akiyama H
- Journal Title
  
  J Neuropahol Exp Neurol
  
  Volume: 74 Issue: 2 Pages: 158-165
- DOI
  10.1097/nen.0000000000000158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23228004, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26461733
[Journal Article] S6 kinase phosphorylated at T229 is involved in tau and actin pathologies in Alzheimer's disease.2015
- Author(s)
  Sonoda Y, Tooyama I, Mukai H, Maeda K, Akiyama H, Kawamata T.
- Journal Title
  
  Neuropathology.
  
  Volume: 36 Issue: 4 Pages: 325-332
- DOI
  10.1111/neup.12275
- Description
  E-pub
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461310
[Journal Article] Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau.2015
- Author(s)
  Takahashi M, Miyata H, Kametani F, Nonaka T, Akiyama H, Hisanaga SI, Hasegawa M.
- Journal Title
  
  Acta Neuropathol.
  
  Volume: 129 Issue: 6 Pages: 895-907
- DOI
  10.1007/s00401-015-1415-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26111730, KAKENHI-PLANNED-26117004, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-25290024
[Journal Article] 思春期に窃盗やわいせつ行為などの行動異常が出現し，診断に難渋したハンチントン病の1例2015
- Author(s)
  河上緒, 新里和弘, 新井哲明, 東晋二, 厚東知成, 秋山治彦
- Journal Title
  
  臨床精神医学
  
  Volume: 44(9) Pages: 1201-1208
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19757
[Journal Article] Feasibility Study: Comparison of Frontal Cortex Needle Core Versus Open Biopsy for Detection of Characteristic Proteinopathies of Neurodegenerative Diseases2015
- Author(s)
  Serrano GE, Intorcia A, Carew J, Chiarolanza G, Hidalgo JA, Sue LI, Dugger BN, Saxon-LaBelle M, Filon J, Scroggins A, Pullen J, Fornwalt BE, Scott S, Sabbagh MN, Adler CH, Akiyama H, Beach TG
- Journal Title
  
  J Neuropathol Exp Neurol
  
  Volume: 74 Issue: 9 Pages: 934-942
- DOI
  10.1097/nen.0000000000000235
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24500429
[Journal Article] Tau accumulation in the nucleus accumbens in tangle-predominant dementia2014
- Author(s)
  Kawakami I, Hasegawa M, Arai T, Ikeda K, Oshima K, Niizato K, Aoki N, Katsuse O, Higashi S, Hosokawa M, Hirayasu Y, Akiyama H
- Journal Title
  
  Acta Neuropathol
  
  Volume: Commun 2 Issue: 1 Pages: 40-40
- DOI
  10.1186/2051-5960-2-40
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26461733
[Journal Article] Distinct pathways leading to TDP-43-induced cellular dysfunctions.2014
- Author(s)
  Yamashita M, Nonaka T, Hirai S, Miwa A, Okado H, Arai T, Hosokawa M, Akiyama H, Hasegawa M.
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 23 Issue: 16 Pages: 4345-56
- DOI
  10.1093/hmg/ddu152
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PROJECT-24700370, KAKENHI-PUBLICLY-25123726, KAKENHI-PUBLICLY-26111730, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26461733
[Journal Article] Differential diagnosis of amyotrophic lateral sclerosis from Guillain-Barré syndrome by quantitative determination of TDP-43 in cerebrospinal fluid.2014
- Author(s)
  Hosokawa M, Arai T, Yamashita M, Tsuji H, Nonaka T, Masuda-Suzukake M, Tamaoka A, Hasegawa M, Akiyama H.
- Journal Title
  
  Int. J. Neurosci.
  
  Volume: 124 Issue: 5 Pages: 344-349
- DOI
  10.3109/00207454.2013.848440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23700433, KAKENHI-PUBLICLY-24111556, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PUBLICLY-25110738
[Journal Article] An Autopsy case of concurrent Huntington’s disease and neurofibromatosis type 1.2014
- Author(s)
  Kawakami I, Katsuse O, Aoki N, Togo T, Suzuki K, Isojima D, Kondo D, Iseki E, Kosaka K, Akiyama H, Hirayasu Y
- Journal Title
  
  Psychogeriatrics
  
  Volume: 14 Issue: 1 Pages: 81-86
- DOI
  10.1111/psyg.12040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791346, KAKENHI-PROJECT-24500429
[Journal Article] 3R and 4R tau isoforms in paired helical filaments in Alzheimer's disease.2014
- Author(s)
  Hasegawa, M., S. Watanabe, H. Kondo, H. Akiyama, D. M. Mann, Y. Saito and S. Murayama
- Journal Title
  
  Acta Neuropathol
  
  Volume: 127 Issue: 2 Pages: 303-305
- DOI
  10.1007/s00401-013-1191-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-24300133, KAKENHI-PROJECT-24500429, KAKENHI-PUBLICLY-25110738
[Journal Article] Pathological alpha-synuclein propagates through neural networks2014
- Author(s)
  Masuda-Suzukake M, Nonaka T, Hosokawa M, Kubo M, Shimozawa A, Akiyama H, Hasegawa M
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: 2 Issue: 1 Pages: 88-88
- DOI
  10.1186/preaccept-1296467154135944
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PUBLICLY-26111730, KAKENHI-PLANNED-26117005
[Journal Article] Submandibular gland needle biopsy for the diagnosis of Parkinson disease2014
- Author(s)
  Adler CH, Dugger BN, Hinni ML, Lott DG, Driver-Dunckley E, Hidalgo J, Henry-Watson J, Serrano G, Sue LI, Nagel T, Duffy A, Shill HA, Akiyama H, Walker DG, *Beach TG
- Journal Title
  
  Neurology
  
  Volume: 82 Issue: 10 Pages: 858-864
- DOI
  10.1212/wnl.0000000000000204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500429
[Journal Article] Atypical FTLD-FUS associated with ALS-TDP : a case report2013
- Author(s)
  Kobayashi Z, Arai T, Yokota O, Tsuchiya K, Hosokawa M, Oshima K, Niizato K, Akiyama H, Mizusawa H
- Journal Title
  
  Neuropathology
  
  Volume: 33 Issue: 1 Pages: 83-86
- DOI
  10.1111/j.1440-1789.2012.01325.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738
[Journal Article] Prion-like spreading of pathological alpha-synuclein in brain.2013
- Author(s)
  Masuda-Suzukake M, Nonaka T, Hosokawa M., Oikawa T, Arai T, Akiyama H, Mann D, Hasegawa M
- Journal Title
  
  Brain
  
  Volume: 136 Issue: 4 Pages: 1128-38
- DOI
  10.1093/brain/awt037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-23700433, KAKENHI-PUBLICLY-24111556, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PUBLICLY-25110738, KAKENHI-PUBLICLY-23110526
[Journal Article] Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains.2013
- Author(s)
  Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann DM, Akiyama H, Hasegawa M.
- Journal Title
  
  Cell Rep.
  
  Volume: 4 Issue: 1 Pages: 124-34
- DOI
  10.1016/j.celrep.2013.06.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-23700433, KAKENHI-PUBLICLY-24111556, KAKENHI-PROJECT-24500429, KAKENHI-PUBLICLY-25110738
[Journal Article] Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer’s disease brain.2013
- Author(s)
  Dan A, Takahashi M, Masuda-Suzukake M, Kametani F, Nonaka T, Kondo H, Akiyama H, Arai T, Mann DMA, Saito Y, Hatsuta H, Murayama S, Hasegawa M.
- Journal Title
  
  Acta Neuropathol. Commun.
  
  Volume: 1 Issue: 1 Pages: 54-54
- DOI
  10.1186/2051-5960-1-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23700433, KAKENHI-PUBLICLY-24111556, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24700371, KAKENHI-PUBLICLY-25110738
[Journal Article] Pathological features of FTLD-FUS in a Japanese population: Analyses of nine cases.2013
- Author(s)
  Kobayashi Z, Kawakami I, Arai T, Yokota O, Tsuchiya K, Kondo H, Shimomura Y, Haga C, Aoki N, Hasegawa M, Hosokawa M, Oshima K, Niizato K, Ishizu H, Terada S, Onaya M, Ikeda M, Oyanagi K, Nakano I, Murayama S, Akiyama H, Mizusawa H.
- Journal Title
  
  Neurol. Sci.
  
  Volume: 335 Issue: 1-2 Pages: 89-95
- DOI
  10.1016/j.jns.2013.08.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591714, KAKENHI-PROJECT-24591738, KAKENHI-PUBLICLY-25110738
[Journal Article] Methylene blue reduced abnormal tau accumulation in P301L tau transgenic mice.2012
- Author(s)
  Hosokawa M
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 12 Pages: e52389-e52389
- DOI
  10.1371/journal.pone.0052389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-23700433, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PUBLICLY-23110526
[Journal Article] Biochemical increase in phosphorylated alpha-synuclein precedes histopathology of Lewy-type synucleinopathies2012
- Author(s)
  Lue LF, Walker DG, Adler CH, Shill H, Tran H, Akiyama H, Sue LI, Caviness J, Sabbagh MN, Beach TG
- Journal Title
  
  Brain Pathol
  
  Volume: (in press) Issue: 6 Pages: 745-756
- DOI
  10.1111/j.1750-3639.2012.00585.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536
[Journal Article] Post mortem cerebrospinal fluidα-synuclein levels are raised in multiple system atrophy and distinguish this from the otherα-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies2012
- Author(s)
  Foulds PG, Yokota O, Thurston A, Davidson Y, Ahmed Z, Holton J, Thompson JC, Akiyama H, Arai T, Hasegawa M, Gerhard A, Allsop D, Mann DM
- Journal Title
  
  Neurobiol Dis
  
  Volume: 45 Issue: 1 Pages: 188-95
- DOI
  10.1016/j.nbd.2011.08.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536, KAKENHI-PUBLICLY-23110526, KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23591694
[Journal Article] Long-term oral intake of aluminium or zinc does not accelerate Alzheimer pathology in AβPP and AβPP/tau transgenic mice2012
- Author(s)
  Akiyama H, Hosokawa M, Kametani F, Kondo H, Chiba M, Fukushima M, Tabira T
- Journal Title
  
  Neuropathology
  
  Volume: (in press) Issue: 4 Pages: 390-397
- DOI
  10.1111/j.1440-1789.2011.01274.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536, KAKENHI-PROJECT-22791157, KAKENHI-PROJECT-24591738
[Journal Article] Molecular analysis and biochemical classification of TDP-43 proteinopathy2012
- Author(s)
  Tsuji H
- Journal Title
  
  Brain
  
  Volume: 135(11) Issue: 11 Pages: 3380-91
- DOI
  10.1093/brain/aws230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300118, KAKENHI-PROJECT-22590968, KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23500435, KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-23700433, KAKENHI-PROJECT-24300133, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591249, KAKENHI-PROJECT-24591738, KAKENHI-PUBLICLY-23110526
[Journal Article] Localization of fused in sarcoma(FUS) protein to the post synaptic density in the brain2012
- Author(s)
  Aoki N, Higashi S, Kawakami I, Kobayashi Z, Hosokawa M, Katsuse O, Togo T, Hirayasu Y, Akiyama H
- Journal Title
  
  Acta Neuropathol
  
  Volume: (in press) Issue: 3 Pages: 383-94
- DOI
  10.1007/s00401-012-0984-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536, KAKENHI-PROJECT-22591292, KAKENHI-PROJECT-23791008, KAKENHI-PROJECT-23791346, KAKENHI-PROJECT-24500429
[Journal Article] Localization of fused in sarcoma (FUS) protein to the post-synaptic density in the brain2012
- Author(s)
  Naoya Aoki, Shinji Higashi, Ito Kawakami, Zen Kobayashi, Masato Hosokawa, Omi Katsuse, Takashi Togo, Yoshio Hirayasu, Haruhiko Akiyama
- Journal Title
  
  Acta Neuropathol
  
  Volume: 124 Pages: 383-94
- Data Source
  KAKENHI-PROJECT-23791008
[Journal Article] Progressive nonfluent aphasia : A rare clinical subtype of FTLD-TDP in Japan2012
- Author(s)
  Aoki N, Tsuchiya K, Kobayashi Z, Arai T, Togo T, Miyazaki H, Kondo H, Ishizu H, Uchikado H, Katsuse O, Hirayasu Y, Akiyama H
- Journal Title
  
  Neuropathology
  
  Volume: (in press) Issue: 3 Pages: 272-9
- DOI
  10.1111/j.1440-1789.2011.01253.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536, KAKENHI-PROJECT-22591292, KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-23791346
[Journal Article] Gray matter lesions in Nasu-Hakola disease : A report on three autopsy ca2011
- Author(s)
  Aoki N, Tsuchiya K, Togo T, Kobayashi Z, Uchikado H, Katsuse O, Suzuki K, Fujishiro H, Arai T, Iseki E, Anno M, Kosaka K, Akiyama H, Hirayasu Y
- Journal Title
  
  Neuropathology
  
  Volume: 31 Issue: 2 Pages: 135-143
- DOI
  10.1111/j.1440-1789.2010.01152.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536, KAKENHI-PROJECT-21791142, KAKENHI-PROJECT-22591292, KAKENHI-PROJECT-23591694
[Journal Article] Effect of glycogen synthase kinase 3 β-mediated presenilin 1 phosphorylation on amyloid β production is negatively regulated by insulin receptor cleavage2011
- Author(s)
  Maesako M, Uemura K, Kubota M, Hiyoshi K, Ando K, Kuzuya A, Kihara T, Asada M, Akiyama H, Kinoshita A
- Journal Title
  
  Neurosci
  
  Volume: 177 Pages: 298-307
- DOI
  10.1016/j.neuroscience.2010.12.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536
[Journal Article] Molecular Dissection of TDP-43 Proteinopathies2011
- Author(s)
  Hasegawa M, Nonaka T, Tsuji H, et al
- Journal Title
  
  J Mol Neurosci
  
  Volume: 45(3) Issue: 3 Pages: 480-5
- DOI
  10.1007/s12031-011-9571-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500339, KAKENHI-PROJECT-21591536, KAKENHI-PUBLICLY-23110526, KAKENHI-PROJECT-23591694
[Journal Article] Fatal Encephalitis in a Case of Hypereosinophilic Syndrome: MRI and Autopsy Findings2011
- Author(s)
  Kobayashi Z, Tsuchiya K, Komachi H, Miki K, Yokota O, Arai T, Miake H, Ishizu H, Akiyama H, Mizusawa H
- Journal Title
  
  Intern. Med.
  
  Volume: 50 Issue: 11 Pages: 1219-1225
- DOI
  10.2169/internalmedicine.50.4570
- NAID
  130000770476
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536
[Journal Article] Epitope mapping of antibodies against TDP-43 and detection of protease-resistant fragments of pathological TDP-43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration2011
- Author(s)
  Tsuji H, Nonaka T, Yamashita M, Suzukake M, Kametani F, Akiyama H, Mann D. M. A., Tamaoka A, Hasegawa M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 417 Issue: 1 Pages: 116-121
- DOI
  10.1016/j.bbrc.2011.11.066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536, KAKENHI-PUBLICLY-23110526, KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23700433
[Journal Article] Clinicopathological study of diffuse neurofibrillary tangles with calcification. With special reference to TDP-43 proteinopathy and alpha-synucleinopathy2011
- Author(s)
  Habuchi C, Iritani S, Sekiguchi H, Torii Y, Ishihara R, Arai T, Hasegawa M, Tsuchiya K, Akiyama H, Shibayama H, Ozaki N
- Journal Title
  
  J Neurol Sci
  
  Volume: 301 Issue: 1-2 Pages: 77-85
- DOI
  10.1016/j.jns.2010.10.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536, KAKENHI-PUBLICLY-23110526, KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23591694
[Journal Article] FALS with Gly72Ser mutation in SOD1 gene : Report of a family including the first autopsy case2011
- Author(s)
  Kobayashi Z, Tsuchiy Kobayashi Z, Tsuchiya K, Kubodera T, Shibata N, Arai T, Miura H, Ishikawa C, Kondo H, Ishizu H, Akiyama H, Mizusawa H
- Journal Title
  
  Neurol Sci
  
  Volume: 300 Issue: 1-2 Pages: 9-13
- DOI
  10.1016/j.jns.2010.10.030
- NAID
  120007137590
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536, KAKENHI-PROJECT-23591694
[Journal Article] Effect of topographical distribution ofα-synuclein pathology on TDP-43 accumulation in Lewy body disease2010
- Author(s)
  Yokota O, Davidson Y, Arai T, Hasegawa M, Akiyama H, Ishizu H, Terada S, Sikkink S, Pickering-Brown S, Mann DM
- Journal Title
  
  Acta Neuropathol
  
  Volume: 120 Issue: 6 Pages: 789-801
- DOI
  10.1007/s00401-010-0731-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536
[Journal Article] Familial ALS with G298S Mutation in TARDBP: A Comparison of CSF Tau Protein Levels with those in Sporadic ALS2010
- Author(s)
  Nozaki I, Arai M, Takahashi K, Hamaguchi T, Yoshikawa H, Muroishi T, Noguchi-Shinohara M, Ito H, Itokawa M, Akiyama H, Kawata A, Yamada M
- Journal Title
  
  Intern. Med.
  
  Volume: 49 Issue: 12 Pages: 1209-1212
- DOI
  10.2169/internalmedicine.49.3300
- NAID
  130000251656
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536
[Journal Article] Phosphorylated and cleaved TDP-43 in ALS/FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy2010
- Author(s)
  Arai T, Hasegawa M, Nonoka T, et al
- Journal Title
  
  Neuropathology
  
  Volume: 30 Issue: 2 Pages: 170-181
- DOI
  10.1111/j.1440-1789.2009.01089.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500339, KAKENHI-PROJECT-21591536
[Journal Article] Argyrophilic grain disease with delusions and hallucinations : a pathological study2010
- Author(s)
  Asaoka T, Tsuchiya K, Fujishiro H, Arai T, Hasegawa M, Akiyama H, Iseki E, Oda T, Onaya M, Tominaga I
- Journal Title
  
  Psychogeriatrics
  
  Volume: 10 Pages: 69-76
- NAID
  10029770939
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536
[Journal Article] Pseudopolyneuritic form of ALS revisited : clinical and pathological heterogeneity2010
- Author(s)
  Kobayashi Z, Tsuchiya K, Arai T, Yokota O, Watabiki S, Ishizu H, Akiyama H, Mizusawa H
- Journal Title
  
  Neuropathology
  
  Volume: 30 Issue: 4 Pages: 372-380
- DOI
  10.1111/j.1440-1789.2009.01084.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536
[Journal Article] Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsy2010
- Author(s)
  Yokota O, Davidson Y, Bigio EH, Ishizu H, Terada S, Arai T, Hasegawa M, Akiyama H, Sikkink S, Pickering-Brown S, Mann DM
- Journal Title
  
  Acta Neuropathol
  
  Volume: 120 Issue: 1 Pages: 55-66
- DOI
  10.1007/s00401-010-0702-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536
[Journal Article] Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders2010
- Author(s)
  Beach TG, Adler CH, Sue LI, Vedders L, Lue L, White Iii CL, Akiyama H, et al.[8番目/12名]
- Journal Title
  
  Acta Neuropathol
  
  Volume: 119 Issue: 6 Pages: 689-702
- DOI
  10.1007/s00401-010-0664-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536
[Journal Article] Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease2010
- Author(s)
  Coomaraswamy J, Kilger E, Wolfing H, Schafer C, Kaeser SA, Wegenast-Braun BM, Hefendehl JK, Wolburg H, Mazzella M, Ghiso J, Goedert M, Akiyama H, et al.[12番目/16名]
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 107 Issue: 17 Pages: 7969-7974
- DOI
  10.1073/pnas.1001056107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536
[Journal Article] Frontotemporal lobar degeneration with motor neuron disease showing severe and circumscribed atrophy of anterior temporal lobes2010
- Author(s)
  Kuwahara H, Tsuchiya K, Saito Y, Kobayashi Z, Miyazaki H, Izumiyama Y, Akiyama H, Arai T, Mizusawa H
- Journal Title
  
  J Neurol Sci
  
  Volume: 297 Issue: 1-2 Pages: 92-96
- DOI
  10.1016/j.jns.2010.07.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536
[Journal Article] TDP-43 M337V Mutation in Familial Amyotrophic Lateral Sclerosis in Japan2010
- Author(s)
  Tamaoka A, Arai M, Itokawa M, Arai T, Hasegawa M, Tsuchiya K, Takuma H, Tsuji H, Ishii A, Watanabe M, Takahashi Y, Goto J, Tsuji S, Akiyama H
- Journal Title
  
  Intern. Med.
  
  Volume: 49 Issue: 4 Pages: 331-334
- DOI
  10.2169/internalmedicine.49.2915
- NAID
  130000152618
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536
[Journal Article] Clinicopathological characteristics of FTLD-TDP showing corticospinal tract degeneration but lacking lower motor neuron loss2010
- Author(s)
  Kobayashi Z, Tsuchiya K, Arai T
- Journal Title
  
  J Neurol Sci
  
  Volume: 298 Issue: 1-2 Pages: 70-77
- DOI
  10.1016/j.jns.2010.08.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500339, KAKENHI-PROJECT-21591536
[Journal Article] Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration : an update2010
- Author(s)
  Mackenzie IR, Neumann M, Bigio EH, Cairns NJ, Alafuzoff I, Kril J, Kovacs GG, Ghetti B, Halliday G, Holm IE, Ince PG, Kamphorst W, Revesz T, Rozemuller AJ, Kumar-Singh S, Akiyama H, et al.[16番目/21名]
- Journal Title
  
  Acta Neuropathol
  
  Volume: 119 Issue: 1 Pages: 1-4
- DOI
  10.1007/s00401-009-0612-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536
[Journal Article] Occurrence of basophilic inclusions and FUS-immunoreactive neuronal and glial inclusions in a case of familial amyotrophic lateral sclerosis2010
- Author(s)
  Kobayashi Z, Tsuchiya K, Arai T, Aoki M, Hasegawa M, Ishizu H, Akiyama H, Mizusawa H
- Journal Title
  
  Neurol Sci
  
  Volume: 293 Issue: 1-2 Pages: 6-11
- DOI
  10.1016/j.jns.2010.03.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536
[Journal Article] Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-432009
- Author(s)
  Nonaka T, Kametani F, Arai T, Akiyama H, Hasegawa M
- Journal Title
  
  Hum Mol Genet
  
  Volume: 18 Issue: 18 Pages: 3353-3364
- DOI
  10.1093/hmg/ddp275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536
[Journal Article] Unified staging system for lewy body disorders : Correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction2009
- Author(s)
  Beach TG, Adler CH, Lue LF, Sue LI, Bachalakuri J, Henry-Watson J, Sasse J, Boyer S, Shirohi S, Brooks R, Eschbacher J, White CL III, Akiyama H, et al.[13番目/18名]
- Journal Title
  
  Acta Neuropathol
  
  Volume: 117 Issue: 6 Pages: 613-634
- DOI
  10.1007/s00401-009-0538-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536
[Journal Article] Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration2009
- Author(s)
  Foulds PG, Davidson Y, Mishra M, Hobson DJ, Humphreys KM, Taylor M, Johnson N, Weintraub S, Akiyama H, et al.[9番目/15名]
- Journal Title
  
  Acta Neuropathol
  
  Volume: 118 Issue: 5 Pages: 647-658
- DOI
  10.1007/s00401-009-0594-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536
[Journal Article] TDP-43 pathology in familial British dementia2009
- Author(s)
  Schwab C, Arai T, Hasegawa M, Akiyama H, Yu S, McGeer PL
- Journal Title
  
  Acta Neuropathol
  
  Volume: 118 Issue: 2 Pages: 303-311
- DOI
  10.1007/s00401-009-0514-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536
[Journal Article] Clinicopathological characterization of Pick's disease versus frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusions2009
- Author(s)
  Yokota O, Tsuchiya K, Arai T, Yagishita S, Matsubara O, Mochizuki A, Tamaoka A, Kawamura M, Yoshida H, Terada S, Ishizu H, Kuroda S, Akiyama H
- Journal Title
  
  Acta Neuropathol
  
  Volume: 117 Issue: 4 Pages: 429-444
- DOI
  10.1007/s00401-009-0493-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536
[Journal Article] TDP-43 in ubiquitinated inclusions in the inferior olives in frontotemporal lobar degeneration and in other neurodegenerative diseases : a degenerative process distinct from normal ageing2009
- Author(s)
  Davidson Y, Amin H, Kelley T, Shi J, Tian J, Kumaran R, Lashley T, Lees AJ, DuPlessis D, Neary D, Snowden J, Akiyama H, et al.[12番目/18名]
- Journal Title
  
  Acta Neuropathol
  
  Volume: 118 Issue: 3 Pages: 359-369
- DOI
  10.1007/s00401-009-0526-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536
[Journal Article] Identification of casein kinase-1 phosphorylation sites on TDP-432009
- Author(s)
  Kametani F, Nonaka T, Suzuki T, Arai T, Dohmae N, Akiyama H, Hasegawa M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 382 Issue: 2 Pages: 405-409
- DOI
  10.1016/j.bbrc.2009.03.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536
[Journal Article] Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models2009
- Author(s)
  Yamashita M, Nonaka T, Arai T, Kametani F, Buchman VL, Ninkina N, Bachurin SO, Akiyama H, Goedert M, Hasegawa M
- Journal Title
  
  FEBS Lett
  
  Volume: 583 Issue: 14 Pages: 2419-2424
- DOI
  10.1016/j.febslet.2009.06.042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536
[Journal Article] Japanese encephalitis : serial CT findings and neuropathology in an autopsy case2009
- Author(s)
  Kobayashi Z, Tsuchiya K, Yokota O, Haga C, Arai T, Akiyama H, Kotera M, Mizusawa H
- Journal Title
  
  Clin Neuropathol
  
  Volume: 28 Pages: 422-429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536
[Journal Article] 病理学からみた認知症におけるニコチン性アセチルコリン受容体の意義とその機能2006
- Author(s)
  秋山治彦
- Journal Title
  
  Cognition and Dementia 5
  
  Pages: 7-12
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] アミロイドβタンパク質(Aβ),タウ,αシヌクレインとグリア2006
- Author(s)
  秋山治彦
- Journal Title
  
  神経精神薬理学雑誌 26
  
  Pages: 23-31
- NAID
  10017327997
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] 認知症の予防と治療,そのエビデンス 5.内科疾患からみた認知症の予防 3)神経炎症の立場から(NSAIDsなども含め)2006
- Author(s)
  秋山治彦
- Journal Title
  
  Progress in Medicine 26
  
  Pages: 415-419
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] 病理学からみた認知症におけるニコチン性アセチルコリン受容体の意義とその機能2006
- Author(s)
  秋山治彦
- Journal Title
  
  Cognition and Dementia 5 : 7-12 5
  
  Pages: 7-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] アルツハイマー病の治療:NMDA受容体拮抗薬,NSAIDs等2005
- Author(s)
  秋山治彦
- Journal Title
  
  モダンフィジシャン 25
  
  Pages: 1092-1095
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] アルツハイマー病の治療 : NMDA受容体拮抗薬,NSAIDs等2005
- Author(s)
  秋山治彦
- Journal Title
  
  モダンフィジシャン 25
  
  Pages: 1092-1095
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] アルツハイマー病とミクログリア2005
- Author(s)
  秋山治彦
- Journal Title
  
  神経研究の進歩 49
  
  Pages: 347-356
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] 抗炎症薬による治療アプローチの現状と課題2005
- Author(s)
  秋山治彦
- Journal Title
  
  老年精神医学 16(増刊III)
  
  Pages: 135-140
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] Specificity of mechanisms for plaque removal after Abeta immunotherapv for Alzheimer's disease.2004
- Author(s)
  Akiyama H, McGeer PL
- Journal Title
  
  Nat Med 10
  
  Pages: 117-118
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] Expression of BRI, the normal precursor forof the amyloid protein of familial British dementia, in human brain,2004
- Author(s)
  Akiyama H, et al.
- Journal Title
  
  Acta Neuropathol 107
  
  Pages: 53-84
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] Specificity of mechanisms for plaque removal after Abeta immunotherapy for Alzheimer's disease.2004
- Author(s)
  Akiyama H, McGeer PL
- Journal Title
  
  Nat Med 10
  
  Pages: 117-118
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] ミクログリアの病理学的所見2004
- Author(s)
  秋山治彦
- Journal Title
  
  Cognition & Dementia 3
  
  Pages: 35-40
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] Sporadic amyotrophic lateral sclerosis of long duration mimicking spinal progressive muscular atrophy exists : Additional autopsy case with a clinical course of 19 years.2004
- Author(s)
  Tsuchiya K, Sano M, Shiotsu H, Akiyama H, Watabiki S, Taki K, Kondo H, et al.
- Journal Title
  
  Neuropathology 24
  
  Pages: 228-235
- NAID
  10014201787
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] アルツハイマー病 : 抗炎症薬2004
- Author(s)
  秋山治彦
- Journal Title
  
  Brain Medical 16
  
  Pages: 16-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] Identification of amino-terminally cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration2004
- Author(s)
  Arai t, Ikeda K, Akiyama H, Nonaka T, Hasegawa M, Ishiguro K, Iritani S, et al.
- Journal Title
  
  Ann Neurol 55
  
  Pages: 71-79
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] Amino-truncated amyloid beta-peptide(Abeta5-40/42) produced from caspase-cleaved amyloid precursor protein is deposited in Alzheimer's disease brain.2004
- Author(s)
  Takeda K, Araki W, Akiyama H, Tabira T
- Journal Title
  
  FASEB J 18
  
  Pages: 1755-1757
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] Expression of BRI, the normal precursor for the amyloid protein of familial British dementia, in human brain2004
- Author(s)
  Akiyama H, Kondo H, Arai T, Ikeda K, Kato M, Iseki E, Scwab C, McGeer PL
- Journal Title
  
  Acta Neuropathol 107
  
  Pages: 53-84
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] Identification of amino-terminally cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration2004
- Author(s)
  Arai T, Ikeda K, Akiyama H, Nonaka T, Hasegawa M, Ishiguro K, Iritani S
- Journal Title
  
  Ann Neurol 55
  
  Pages: 71-79
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] Immunohistochemical study of tau accumulation in early stages of Alzheimer-type neurofibrillary lesions.2004
- Author(s)
  Togo T, Akiyama H, Iseki E, Uchikado H, Kondo H, Ikeda K, Tsuchiya K, et al.
- Journal Title
  
  Acta Neuropathol 107
  
  Pages: 504-508
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] Activation of vascular endothelial cells and perivascular cells by systemic inflammation - an immunohistochemical study of postmortem human brain tissues -2004
- Author(s)
  Uchikado H, Akiyama H, Kondo H, Ikeda K, Tsuchiya K, Kato M, Oda T, et al.
- Journal Title
  
  Acta Neuropathol 107
  
  Pages: 341-351
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] ミクログリアとアミロイドβ蛋白質2004
- Author(s)
  秋山治彦
- Journal Title
  
  医学のあゆみ 209
  
  Pages: 905-906
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] Expression of BRI, the normal precursor forof the amyloid protein of familial British dementia, in human brain2004
- Author(s)
  Akiyama H, Kondo H, Arai T, Ikeda K, Kato M, Iseki E, Scwab C, McGeer PL
- Journal Title
  
  Acta Neuropathol 107
  
  Pages: 53-84
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] 抗炎症剤による治療の試みの現況2003
- Author(s)
  秋山治彦
- Journal Title
  
  老年精神医学雑誌 14
  
  Pages: 539-544
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] アルツハイマー病と免疫・炎症反応-Aβワクチン,抗炎症剤2003
- Author(s)
  秋山治彦
- Journal Title
  
  Dementia Japan 17
  
  Pages: 117-125
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570957
[Journal Article] TDP-43 associates with stalled ribosomes and contributes to cell survival during cellular stress
- Author(s)
  Shinji Higashi, Tomohiro Kabuta, Yoshitaka Nagai, Yukihiro Tsuchiya, Haruhiko Akiyama, Keiji Wada
- Journal Title
  
  J Neurochem
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791008
[Presentation] Chorea as a clinical feature of BIBD subtype of FTLD-FUS2016
- Author(s)
  Ito Kawakami, Zen Kobayashi, Tetsuaki Arai, Osamu Yokota, Takashi Nonaka, Kazuhiro Niizato, Kenichi Oshima, Shinji Higashi, Masato Hosokawa, Masato Hasegawa and Haruhiko Akiyama
- Organizer
  10th International Conference on Frontotemporal Dementia
- Place of Presentation
  ミュンヘン（ドイツ）
- Year and Date
  2016-08-31
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19757
[Presentation] 神経原線維変化型認知症とアルツハイマー病の線条体における異常タウ蛋白伝播の検討2016
- Author(s)
  河上緒、新井哲明、池田研二、新里和弘、大島健一、近藤ひろみ、秋山治彦、長谷川成人
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15K19757
[Presentation] tangle-predominant dementia（神経原線維変化型老年期認知症）の精神症状に関する多施設共同研究2016
- Author(s)
  河上緒、新井哲明、新里和弘、大島健一、勝瀬大海、赤津裕康、橋詰良夫、池田研二、秋山治彦
- Organizer
  第112回日本精神神経学会学術集会
- Place of Presentation
  幕張メッセ（千葉県千葉市）
- Year and Date
  2016-06-02
- Data Source
  KAKENHI-PROJECT-15K19757
[Presentation] 初診時に緊張病症候群と診断された FTLD-TDP の一例．2016
- Author(s)
  渡辺亮平,　河上緒,　朝岡俊泰, 大島健一, 新里和弘, 東　晋二,　女屋光基,　新井信隆,　長谷川成人, 秋山治彦, 新井哲明
- Organizer
  第57回日本神経病理学会総会学術研究会,
- Place of Presentation
  青森県弘前市（ホテルニューキャッスル）
- Year and Date
  2016-06-01
- Data Source
  KAKENHI-PROJECT-15K09822
[Presentation] Chorea as a clinical feature of BIBD subtype of FTLD-FUS2016
- Author(s)
  Ito Kawakami, Zen Kobayashi, Tetsuaki Arai, Osamu Yokota, Takashi Nonaka, Naoya Aoki, Kazuhiro Niizato, Kenichi Oshima, Shinji Higashi, Omi Katsuse, Masato Hosokawa, Masato Hasegawa and Haruhiko Akiyama
- Organizer
  10th International Conference on Frontotemporal Dementias
- Place of Presentation
  ミュンヘン(ドイツ)
- Year and Date
  2016-08-31
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19757
[Presentation] タウオパチーの線条体におけるタウ異常蓄積の検討2016
- Author(s)
  河上緒, 新井　哲明, 新里　和弘, 大島　健一, 池田研二, 秋山　治彦, 長谷川　成人
- Organizer
  第31回日本老年精神医学会
- Place of Presentation
  金沢歌劇座（石川県金沢市）
- Year and Date
  2016-06-23
- Data Source
  KAKENHI-PROJECT-15K19757
[Presentation] グラニュリン変異脳における神経変性疾患関連タンパク質の重複蓄積2015
- Author(s)
  細川雅人，新井哲明，近藤ひろみ，長谷川成人，秋山治彦
- Organizer
  第34回日本認知症学会
- Place of Presentation
  リンクステーション青森（青森県青森市）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-24500429
[Presentation] tangle-predominant dementiaの精神医学的特徴2015
- Author(s)
  河上緒, 新井哲明, 新里和弘, 大島健一, 勝瀬大海, 赤津裕康, 橋詰良夫, 池田研二, 秋山治彦1
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  リンクステーションホール青森, ホテル青森(青森県弘前市)
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-15K19757
[Presentation] 非定型タウオパチーの二剖検例2015
- Author(s)
  河上　緒, 新井哲明, 池田研二, 大島健一, 新里和弘, 細川雅人, 長谷川成人, 秋山治彦
- Organizer
  第56回日本神経病理学会総会学術研究会
- Place of Presentation
  九州大学医学部百年講堂(福岡県福岡市)
- Year and Date
  2015-06-03
- Data Source
  KAKENHI-PROJECT-15K19757
[Presentation] タウP301L変異が確認されたFTDP-17の1例2014
- Author(s)
  鈴木寿臣，女屋光基，野島照雄，冨永格，織田辰郎，三村將，小林智則，長谷川成人，秋山治彦
- Organizer
  第55回日本神経病理学会
- Place of Presentation
  一橋講堂（東京都）
- Year and Date
  2014-06-07
- Data Source
  KAKENHI-PROJECT-24500429
[Presentation] 外傷性脳損傷の脳における神経変性疾患関連たんぱく質の凝集体分布の検討2014
- Author(s)
  東　晋二，羽賀千恵，河上緒，長谷川成人，大島健一，新里和弘，女屋光基，秋山治彦
- Organizer
  第55回日本神経病理学会
- Place of Presentation
  一橋講堂（東京都）
- Year and Date
  2014-06-06
- Data Source
  KAKENHI-PROJECT-24500429
[Presentation] タウトランスジェニックマウスにおいてプログラニュリンの減少はタウのリン酸化に影響を与える2014
- Author(s)
  細川雅人、新井哲明、増田－鈴掛雅美、近藤ひろみ、松脇貴志、西原真杉、長谷川成人、秋山治彦
- Organizer
  第61回　日本実験動物学会
- Place of Presentation
  札幌　札幌コンベンションセンター
- Year and Date
  2014-05-15
- Data Source
  KAKENHI-PROJECT-24591738
[Presentation] 本邦におけるbehavioral variant of frontotemporal dementia (bvFTD) 35例の臨床2014
- Author(s)
  小林　禅，河上　緒，新井哲明，横田修，大島健一，新里和弘，秋山治彦，水澤英洋
- Organizer
  第55回日本神経病理学会
- Place of Presentation
  一橋講堂（東京都）
- Year and Date
  2014-06-06
- Data Source
  KAKENHI-PROJECT-24500429
[Presentation] プログラニュリンの減少はタウのリン酸化を亢進させる2014
- Author(s)
  細川雅人、新井哲明、増田－鈴掛雅美、近藤ひろみ、松脇貴志、西原真杉、長谷川成人、秋山治彦
- Organizer
  第33回　日本認知症学会
- Place of Presentation
  横浜　パシフィコ横浜
- Year and Date
  2014-11-30
- Data Source
  KAKENHI-PROJECT-24591738
[Presentation] AD脳に蓄積するタウの解析2014
- Author(s)
  長谷川成人，近藤ひろみ，齊藤祐子，初田裕幸，村山繁雄，秋山治彦
- Organizer
  第55回日本神経病理学会
- Place of Presentation
  一橋講堂（東京都）
- Year and Date
  2014-06-06
- Data Source
  KAKENHI-PROJECT-24500429
[Presentation] 神経細胞と脳の炎症2014
- Author(s)
  秋山治彦
- Organizer
  第33回日本認知症学会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2014-11-29
- Invited
- Data Source
  KAKENHI-PROJECT-24500429
[Presentation] Analysis of Tau phosphorylation in Tauopathy using Phos-tag SDS-PAGE2014
- Author(s)
  木村妙子、細川智永、堤弘次、初田裕幸、鈴掛－増田雅美、細川雅人、福島寛美、石黒幸一、秋山治彦、村山繁雄、長谷川成人、久永眞市
- Organizer
  第55回　日本神経病理学会
- Place of Presentation
  東京　学術総合センター
- Year and Date
  2014-06-07
- Data Source
  KAKENHI-PROJECT-24591738
[Presentation] Progranulin reduction affects tau phosphorylation in P301L tau transgenic mice2013
- Author(s)
  Hosokawa M, Arai T, Masuda-Suzukake M, Nonaka T, Yamashita M, Matsuwaki T, Nishihara M, Hasegawa M, Akiyama H
- Organizer
  The 11th International Conference on Alzheimer's & Parkinson's Diseases
- Place of Presentation
  Florence, Italy
- Data Source
  KAKENHI-PROJECT-24591738
[Presentation] アルツハイマー病脳における神経炎症2013
- Author(s)
  秋山治彦, 下村洋子, 近藤ひろみ, 羽賀千恵, 細川雅人
- Organizer
  第32回　日本認知症学会
- Place of Presentation
  松本　キッセイ文化ホール
- Invited
- Data Source
  KAKENHI-PROJECT-24591738
[Presentation] 蓄積αシヌクレインはマウス脳内でプリオン様の伝播能を示す2013
- Author(s)
  鈴掛雅美、野中隆、細川雅人、笈川貴行、新井哲明、David M. A. Mann、秋山治彦、長谷川成人
- Organizer
  第86回　日本生化学会
- Place of Presentation
  横浜　パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24591738
[Presentation] タウオパチー病理変化の基礎2013
- Author(s)
  新井哲明, 河上緒, 小林禅, 野中隆, 長谷川成人, 細川雅人, 秋山治彦, 池田研二, 朝田隆
- Organizer
  第32回　日本認知症学会
- Place of Presentation
  松本　キッセイ文化ホール
- Invited
- Data Source
  KAKENHI-PROJECT-24591738
[Presentation] レビー小体型認知症患者脳不溶性画分の脳内接種は野生型マウス脳にレビー小体様病理を形成させる2013
- Author(s)
  鈴掛雅美、野中隆、細川雅人、笈川貴行、新井哲明、秋山治彦、マン　デイビッド、長谷川成人
- Organizer
  第54回　日本神経病理学会
- Place of Presentation
  東京　タワーホール船堀
- Data Source
  KAKENHI-PROJECT-24591738
[Presentation] Methylene blue reduced tau phosphorylation and aggregation in P301L transgenic mice2012
- Author(s)
  Hosokawa M, Arai T, Nonaka T, Yamashita M, Suzukake M, Hasegawa M, Akiyama H
- Organizer
  Alzheimer's Association International Conference 2012
- Place of Presentation
  Vancouver, BC, Canada
- Data Source
  KAKENHI-PROJECT-24591738
[Presentation] Quantitative determination of TDP-43 in cerebrospinal fluid of patients with amyotrophic lateral sclerosis and other neurodegenerative disorders2011
- Author(s)
  Hosokawa M, Arai T, Yamashita M, Tsuji H, Nonaka T, Hasegawa M, Akiyama H
- Organizer
  International Conference on Alzheimer's Disease 2011
- Place of Presentation
  Paris France
- Year and Date
  2011-07-17
- Data Source
  KAKENHI-PROJECT-21591536
[Presentation] Progranulin reduction affects tau phosphorylation in P301L tau transgenic mice2011
- Author(s)
  Hosokawa M, Arai T, Nonaka T, Yamashita M, Suzukake M, Matsuwaki T, Nishihara M, Hasegawa M, Akiyama H
- Organizer
  Neuroscience 2011
- Place of Presentation
  Washington D. C., USA
- Year and Date
  2011-11-14
- Data Source
  KAKENHI-PROJECT-21591536
[Presentation] Progranulin reduction affects tau phosphorylation in P301L tau transgenic mice2011
- Author(s)
  Hosokawa M, Arai T, Nonaka T, Yamashita M, Suzukake M, Matsuwaki T, Nishihara M, Hasegawa M, Akiyama H
- Organizer
  Neuroscience 2011
- Place of Presentation
  Washington D.C.USA
- Year and Date
  2011-11-14
- Data Source
  KAKENHI-PROJECT-21591536
[Presentation] Screening for FUS proteinopathy in the institutional brain collection2010
- Author(s)
  Akiyama H, Kobayashi Z, Arai T, Hosokawa M, Tsuchiya K, Yokota O, Shimomura Y, Kondo H, Haga C, Hasegawa M
- Organizer
  The 7th International Conference on Frontotemporal Dementias
- Place of Presentation
  Indianapolis, USA
- Year and Date
  2010-10-06
- Data Source
  KAKENHI-PROJECT-21591536
[Presentation] Neuroinflammation in the frontal cortex of patients with late-life depression2010
- Author(s)
  Akiyama H, Arai T, Kondo H, Ikeda K, Beach TG
- Organizer
  The 17th International Congress of Neuropathology
- Place of Presentation
  Salzburg, Austria
- Year and Date
  2010-09-11
- Data Source
  KAKENHI-PROJECT-21591536
[Presentation] アルツハイマー病およびレヴィー小体型認知症脳における progranulin の免疫組織化学的検討2009
- Author(s)
  秋山治彦
- Organizer
  第50回日本神経病理学会総会学術研究会
- Place of Presentation
  サンポートホール高松(高松市)
- Year and Date
  2009-06-05
- Data Source
  KAKENHI-PROJECT-21591536
[Presentation] Three Autopsy Cases of FTD-MND with Progressive Aphasia
- Author(s)
  Kawakami I, Higashi S, Aoki N, Niizato K, Oshima K, Katsuse O, Togo T, Kobayashi Z, Hosokawa M, Tsuji H, Tamaoka A, Hasegawa M, Arai T, Tsuchiya K, Hirayasu Y, Akiyama H
- Organizer
  8th International Conference on FTD
- Place of Presentation
  Manchester, UK
- Data Source
  KAKENHI-PROJECT-24500429
[Presentation] 進行性失語が前景に立った運動ニューロン疾患を伴う前頭側頭型認知症の二剖検例
- Author(s)
  河上緖，東晋二，青木直哉，新里和弘，大島健一，安野みどり，羽賀千恵，下村洋子，鈴木京子，勝瀬大海，都甲崇，小林禅，辻浩史，玉岡晃，長谷川成人，新井哲明，土谷邦秋，平安良雄，秋山治彦
- Organizer
  第53回日本神経病理学会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-24500429
[Presentation] 認知症の基礎と臨床
- Author(s)
  秋山治彦
- Organizer
  日本脳神経外科学会
- Place of Presentation
  横浜市
- Invited
- Data Source
  KAKENHI-PROJECT-24500429
[Presentation] Does frontotemporal dementia associated with chorea suggest the diagnosis of frontotemporal lobar degeneration with fused in sarcoma positive inclusions of the basophilic inclusion body disease subtype?
- Author(s)
  Kawakami I, Kobayashi Z, Arai T, Yokota O, Niizato K, Oshima K, Hosokawa M, Akiyama H
- Organizer
  The 11th International Conference on Alzheimer's & Parkinson's Diseases
- Place of Presentation
  Vancouver, B.C. Canada
- Year and Date
  2014-10-23 – 2014-10-25
- Data Source
  KAKENHI-PROJECT-24591738
[Presentation] 老年期発症の幻覚妄想を認め，辺縁系に高度タウ病変を呈した3剖検例
- Author(s)
  河上緖，新井哲明，池田研二，大島健一，新里和弘，東晋二，青木直哉，水上勝義，平安良雄，秋山治彦
- Organizer
  第31回日本認知症学会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-24500429
[Presentation] Localization of Fused in Sarcoma (FUS) Protein to the Post Synaptic Density in the Brain
- Author(s)
  Akiyama H, Aoki N, Higashi S, Kawakami I, Kobayashi Z, Hosokawa M, Togo T, Hirayasu Y
- Organizer
  8th International Conference on FTD
- Place of Presentation
  Manchester, UK
- Data Source
  KAKENHI-PROJECT-24500429
[Presentation] アルツハイマー病脳における神経炎症
- Author(s)
  秋山治彦，下村洋子，近藤ひろみ，羽賀千恵，細川雅人
- Organizer
  日本認知症学会
- Place of Presentation
  松本市
- Invited
- Data Source
  KAKENHI-PROJECT-24500429
[Presentation] Progranulin reduction affects tau phosphorylation in P301L tau transgenic mice
- Author(s)
  Hosokawa M, Arai T, Masuda-Suzukake M, Nonaka T, Yamashita M, Matsuwaki T, Nishihara M, Hasegawa M, Akiyama H
- Organizer
  The 11th International Conference on Alzheimer's and Parkinson's Diseases
- Place of Presentation
  Firenze, Italy.
- Data Source
  KAKENHI-PROJECT-24500429

1. ARAI Tetsuaki (90291145)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
2. HOSOKAWA Masato (00435116)

# of Collaborated Projects: 3 results

# of Collaborated Products: 23 results
3. HIGASHI Shinji (30365647)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. 池田研二 (90232181)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. WADA Keiji (70250222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. KABUTA Tomohiro (70535765)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. NAGAI Yoshitaka (60335354)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. HASEGAWA Masato (10251232)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
9. KAWAKAMI Ito (60748838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
10. ISEKI Eizo (30203061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 川又敏男 (70214690)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 向井秀幸 (80252758)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 高橋美樹子 (90324938)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 前田潔 (80116251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. MATSUWAKI Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. KATSUSE Omi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 西原真杉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 野中隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
19. 平井宏和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 山下俊英

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 長谷川寿一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
22. 岡戸晴生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 青木茂樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
24. 亀谷富由樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 鈴木元治郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 田中良法

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 齋藤実

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 齊藤祐子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 阿部修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 渡辺雅彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 村山繁雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 斎藤泉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

akiyama haruhiko 秋山 治彦

AKIYAMA Haruhiko 秋山 治彦

Research Projects

Research Products

Co-Researchers

The mechanism of tau accumulation in the striatum of tauopathy

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Investigation of protein-RNA interaction implicated in neurodegeneration

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タウ蛋白リン酸化シグナル巨大複合体を介する変性認知症の神経細胞死に関する病態解析

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Pathological study of abnormal protein accumulation and its propagation in the brain of patients with dementiaPrincipal Investigator

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Creation of novel model mice for dementia research and development of new medicines for dementia treatment.

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Investigation of effect of TDP-43 aggregation on translational control

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Experimental research on the pathogenesis and pathophysiology of diseases that cause dementiaPrincipal Investigator

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Psychiatric symptoms as preceding or early signs of dementia of Alzheimer type. A cohort study.Principal Investigator

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タウ蛋白異常疾患脳におけるタウの代謝・処理過程の研究

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Investigation on the amyloid β-protein (Aβ)20231839Principal Investigator

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Phagocytosis and degradation of amyloid beta-protein by microglia in the brain of Alzheimer's diseasePrincipal Investigator

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The mechanism of thrombin deposition in Alzheimer's disease senile plaques and its pathological significancePrincipal Investigator

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[Book] Progress in Alzheimer's and Parkinson's; Diseases (Edited by I. Hanim, R. Cacabelos & A. Fisher)2005

Author(s)

Publisher

akiyama haruhiko 秋山治彦

AKIYAMA Haruhiko 秋山治彦