Tsutsumi Ryohei 堤良平

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Tsutsumi Ryouhei 堤良平

TSUTSUMI Ryohei 堤良平

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Researcher Number	50435872
Other IDs
Affiliation (Current)	2025: 北里大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2022 – 2024: 北里大学, 医学部, 講師 2023: 東北大学, 薬学研究科, 助教 2020 – 2021: 東北大学, 薬学研究科, 講師 2018 – 2020: 東北大学, 薬学研究科, 助教 2014: 東京大学, 大学院医学系研究科, 助教 2012: 東京大学, 医学(系)研究科(研究院), 助教 2010 – 2011: 東京大学, 大学院・医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 44010:Cell biology-related / 0802:Biomedical structure and function and related fields / Tumor biology Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields / Biological Sciences
Keywords	Principal Investigator 細胞内小胞 / 増殖因子 / 細胞内情報伝達 / 解糖系 / 受容体エンドサイトーシス / 情報伝達 / エンドサイトーシス / 細胞等代謝 / 細胞膜受容体 / レドックスシグナル … More / シグナル伝達 / プロテオミクス / タンパク質翻訳後修飾 / パーチオサルフェン化 / 細胞増殖因子 / ホスファターゼ / parafibromin / SHP2 / チロシンホスファターゼ / がん … More Except Principal Investigator セレノプロテイン / セレノプロテインＰ / インスリン抵抗性 / インスリン分泌 / がん / lncRNA / スルフォラフェン / NRF2 / 発現制御 / 2型糖尿病 / 重金属 / コホート研究 / 転写因子 / ICP-MS / 地域住民コホート / メチル水銀 / 亜鉛 / 生活習慣病 / セレン / メタロミクス / 網羅的解析 / 抗酸化システム / 活性酸素種 / レドックス制御 / 骨格筋 / 硫黄代謝 / セレン代謝 / 小胞体ストレス / 膵β細胞 / セレノプロテインP / 還元ストレス / シグナル伝達 / 細菌 / 癌 / 炎症 / ヘリコバクター・ピロリ / 胃がん / 感染症 Less

Clarification of ALK endocytosis-dependent regulation of glucose metabolism in neuroblastomaPrincipal Investigator
- Principal Investigator
  
  堤良平
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kitasato University
Evaluation of molecular bases for signal transduction by "signaling endosomes"Principal Investigator
- Principal Investigator
  
  Tsutsumi Ryouhei
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Kitasato University
  Tohoku University
Regulatory mechanism of selenoprotein P expression and its deterioration mechanism of glucose metabolism
- Principal Investigator
  
  Saito Yoshiro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Tohoku University
Omics analysis for the establishment of "reductive stress," a biological disorder caused by excessive antioxidant and reductive environment
- Principal Investigator
  
  Saito Yoshiro
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Tohoku University
Clarification of molecular bases for signal transduction by "signaling endosomes"Principal Investigator
- Principal Investigator
  
  Tsutsumi Ryouhei
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0802:Biomedical structure and function and related fields
- Research Institution
  Tohoku University
Host response as an enhancer of infection-associated cancer and its regulation
- Principal Investigator
  
  HATAKEYAMA Masanori
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Molecular mechanism of solid tumor formation by oncogenic tyrosine phosphatase SHP2Principal Investigator
- Principal Investigator
  
  TSUTSUMI Ryohei
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  The University of Tokyo

All 2024 2023 2020 2019 2018 2014 2013 2012 2011

All Journal Article Presentation Book

[Book] Hippo経路のエフェクター分子YAPおよびTAZによるがんタンパク質SHP2の機能制御2014
- Author(s)
  高橋　昌史、堤　良平、畠山　昌則
- Publisher
  細胞工学
- Data Source
  KAKENHI-PLANNED-22114002
[Journal Article] Endocytic vesicles act as vehicles for glucose uptake in response to growth factor stimulation2024
- Author(s)
  Tsutsumi Ryouhei、Ueberheide Beatrix、Liang Feng-Xia、Neel Benjamin G.、Sakai Ryuichi、Saito Yoshiro
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1 Pages: 1-15
- DOI
  10.1038/s41467-024-46971-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07105, KAKENHI-PROJECT-20K06633
[Journal Article] Selenoprotein P; P for Plasma, Prognosis, Prophylaxis, and More2020
- Author(s)
  Tsutsumi Ryouhei、Saito Yoshiro
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 43 Issue: 3 Pages: 366-374
- DOI
  10.1248/bpb.b19-00837
- NAID
  130007804438
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2020-03-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21238, KAKENHI-PROJECT-19K22480, KAKENHI-PROJECT-17H03821
[Journal Article] Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis.2019
- Author(s)
  Hamid HA, Tanaka A, Ida T, Nishimura A, Matsunaga T, Fujii S, Morita M, Sawa T, Fukuto JM, Nagy P, Tsutsumi R, Motohashi H, Ihara H, Akaike T.
- Journal Title
  
  Redox Biol
  
  Volume: 21 Pages: 101096-101096
- DOI
  10.1016/j.redox.2019.101096
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07099, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-16H04674, KAKENHI-PROJECT-18H02098, KAKENHI-PROJECT-19K21238, KAKENHI-PROJECT-17F17116, KAKENHI-PROJECT-17K19205, KAKENHI-PROJECT-17K19508, KAKENHI-PROJECT-17K15408, KAKENHI-INTERNATIONAL-15K21759, KAKENHI-PROJECT-19K07554, KAKENHI-PUBLICLY-18H04794, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-17H06170
[Journal Article] Off-target inhibition by active site-targeting SHP2 inhibitors.2018
- Author(s)
  Tsutsumi R, Ran H, Neel BG
- Journal Title
  
  FEBS Open Bio
  
  Volume: 8 Issue: 9 Pages: 1405-1411
- DOI
  10.1002/2211-5463.12493
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21238
[Journal Article] YAP and TAZ, Hippo signaling targets, act as a rheostat for nuclear SHP2 function.2013
- Author(s)
  Tsutsumi, D., Masoodi, M., Takahashi, A., Fujii, Y., Hayashi, T, . Kikuchi, I., et al.
- Journal Title
  
  Developmental Cell
  
  Volume: 26(6) Issue: 6 Pages: 658-665
- DOI
  10.1016/j.devcel.2013.08.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J04126, KAKENHI-ORGANIZER-22114001, KAKENHI-PLANNED-22114002, KAKENHI-PROJECT-24700965, KAKENHI-PROJECT-25250016, KAKENHI-PROJECT-25251026
[Journal Article] SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver2011
- Author(s)
  Takahashi A.、Tsutsumi R.、Kikuchi I.、 Obuse C.、Saito Y.、Seidi A.、Karisch R.、 Fernandez M.、Cho T.、Ohnishi N.、 Rozenblatt-Rosen O.、Meyerson M.、Neel B.G.、Hatakeyama M.
- Journal Title
  
  Molecular cell
  
  Volume: 43(1) Issue: 1 Pages: 45-56
- DOI
  10.1016/j.molcel.2011.05.014
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20114006, KAKENHI-ORGANIZER-22114001, KAKENHI-PLANNED-22114002, KAKENHI-PROJECT-22240085, KAKENHI-PROJECT-22700877
[Presentation] 増殖因子受容体エンドサイトーシスによる細胞ブドウ糖代謝制御2023
- Author(s)
  堤良平、堺隆一、斎藤芳郎
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K06633
[Presentation] 増殖因子による細胞糖代謝制御の新たな分子基盤2020
- Author(s)
  堤良平
- Organizer
  第93回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K06633
[Presentation] Spatio-temporal regulation of protein tyrosine phosphatases by reactive oxygen Species (ROS) and its pharmaceutical application2020
- Author(s)
  堤良平
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K06633
[Presentation] Specific visualization of reversibly oxidized proteins2019
- Author(s)
  Ryouhei Tsutsumi, Benjamin G. Neel, Yoshiro Saito
- Organizer
  9th SFRR Asia Biennial Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21238
[Presentation] 可逆的酸化タンパク質の特異的可視化法の開発2019
- Author(s)
  堤　良平, Benjamin G. Neel, 斎藤芳郎
- Organizer
  第72回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-19K21238
[Presentation] 増殖因子刺激による活性酸素種産生性細胞内小胞の生成2019
- Author(s)
  堤　良平
- Organizer
  日本生化学会東北支部第85回例会
- Data Source
  KAKENHI-PROJECT-19K21238
[Presentation] 新規可視化法により見えてきた「活性酸素種産生小胞」によるチロシンホスファターゼの時空間的制御2019
- Author(s)
  堤　良平
- Organizer
  第92回日本生化学会大会シンポジウム「新たなシグナル検出法・アプローチに基づくリン酸化シグナル研究の新展開」
- Invited
- Data Source
  KAKENHI-PROJECT-19K21238
[Presentation] Visualization of specific protein oxidation evoked by signaling ROS2019
- Author(s)
  Ryouhei Tsutsumi
- Organizer
  The Gordon Research Conference on Oxygen Radicals 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21238
[Presentation] 増殖因子依存的な活性酸素種産生性細胞内小胞の生成と情報伝達2019
- Author(s)
  堤　良平
- Organizer
  レドックス・ライフイノベーション第170委員会20周年記念若手シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19K21238
[Presentation] タンパク質可逆的酸化の特異的可視化による増殖因子依存的「レドキソソーム」情報伝達の発見2018
- Author(s)
  堤　良平
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K21238
[Presentation] Mechanism underlying cytoplasmic-nuclear shuttling of SHP22012
- Author(s)
  Ryouhei Tsutsumi
- Organizer
  第７１回日本癌学会総会
- Place of Presentation
  札幌文芸館、札幌市
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PLANNED-22114002
[Presentation] がんタンパク質SHP2の細胞質・細胞核間輸送2011
- Author(s)
  堤良平, 他
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県名古屋市)
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-22700877
[Presentation] がんタンパク質SHP2の細胞質・細胞核間輸送2011
- Author(s)
  堤良平、高橋昌史、菊地逸平、畠山昌則
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  愛知県
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-22700877
[Presentation] Regulation of intracellular distribution of SHP2 phosphatase2011
- Author(s)
  堤良平
- Organizer
  発がんスパイラル第1回国際シンポジウム&第9回プロテインホスファターゼ国際カンファレンス
- Place of Presentation
  東京大学(東京都文京区)
- Year and Date
  2011-02-01
- Data Source
  KAKENHI-PROJECT-22700877
[Presentation] Cytoplasmic-nuclear shuttling of SHP2 oncoprotein2011
- Author(s)
  Tsutsumi R
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PLANNED-22114002
[Presentation] Regulation of intracellular distribution of SHP2 phosphatase2011
- Author(s)
  Tsutsumi R, Takahashi A, Kikuchi I, Hatakeyama M
- Organizer
  1st International Symposium on Carcinogenic Spiral & 9th International Conference on Protein Phosphatase
- Place of Presentation
  東京都
- Year and Date
  2011-02-01
- Data Source
  KAKENHI-PROJECT-22700877

1. Saito Yoshiro (70357060)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. HATAKEYAMA Masanori (40189551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. KAMIYA Naoko (40279352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MUTOH Hiroyuki (50322392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SAITO Yasuhiro (30613004)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TAKAHASHI Atsushi (00624496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 有澤琴子 (00813122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 金子尚志 (20907993)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 外山喬士 (50720918)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 三田雄一郎 (70609122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 藤井重元

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 井田智章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 堺隆一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 小布施力史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tsutsumi Ryohei 堤 良平

Tsutsumi Ryouhei 堤 良平

TSUTSUMI Ryohei 堤 良平

Research Projects

Research Products

Co-Researchers

Clarification of ALK endocytosis-dependent regulation of glucose metabolism in neuroblastomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of molecular bases for signal transduction by "signaling endosomes"Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulatory mechanism of selenoprotein P expression and its deterioration mechanism of glucose metabolism

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Omics analysis for the establishment of "reductive stress," a biological disorder caused by excessive antioxidant and reductive environment

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarification of molecular bases for signal transduction by "signaling endosomes"Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Host response as an enhancer of infection-associated cancer and its regulation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of solid tumor formation by oncogenic tyrosine phosphatase SHP2Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Hippo経路のエフェクター分子YAPおよびTAZによるがんタンパク質SHP2の機能制御2014

Author(s)

Publisher

Data Source

[Journal Article] Endocytic vesicles act as vehicles for glucose uptake in response to growth factor stimulation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Selenoprotein P; P for Plasma, Prognosis, Prophylaxis, and More2020

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Off-target inhibition by active site-targeting SHP2 inhibitors.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] YAP and TAZ, Hippo signaling targets, act as a rheostat for nuclear SHP2 function.2013

Author(s)

Journal Title

DOI

Tsutsumi Ryohei 堤良平

Tsutsumi Ryouhei 堤良平

TSUTSUMI Ryohei 堤良平

[Presentation] 増殖因子による細胞糖代謝制御の新たな分子基盤2020

[Presentation] タンパク質可逆的酸化の特異的可視化による増殖因子依存的「レドキソソーム」情報伝達の発見2018