SHIBAHARA Shigeki 柴原茂樹

Researcher Number	70206142
Affiliation (based on the past Project Information) *help	2007 – 2010: Tohoku University, School of Medicine, Professor 2006: Tohoku University, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 1999 – 2005: School of Medicine, Tohoku University, Professor, 大学院・医学系研究科, 教授 2001: 東北大学, 医学系研究科, 教授 1989 – 1998: 東北大学, 医学部, 教授 1988: 東北大学, 医学部, 教授
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Biological Sciences / General medical chemistry / Pathological medical chemistry / General medical chemistry Except Principal Investigator Dermatology / Pathological medical chemistry / General medical chemistry / General medical chemistry / General physiology / Pediatric surgery / Pathological medical chemistry / Hygiene
Keywords	Principal Investigator ヘムオキシゲナーゼ / 転写因子 / チロシナーゼ / 遺伝子発現 / メラニン / ヘム / ストレス / 低酸素 / MITF / 細胞分化 … More / アルビニズム / メラノサイト / transcription factor / ヘムオキシゲナ-ゼ / 遺伝子 / エンハンサー / チロシナーゼ関連タンパク / がん / シグナル伝達 / 換気応答 / 酸素センサー / 肺動脈 / tyrosinase / heme oxygenase / cell differentiation / TRP-1 / TRP-2 / melanin / チロシナ-ゼ / 遺伝病 / 色素細胞 / チロシナーゼ関連蛋白 / 神経線維腫症 / ニューロフィブロミン / 神経堤細胞 / 転写 / アドレノメデュリン / 脳マラリア / マイクロサテライト / 遺伝的多型 / 脳・神経 / 発生・分化 / 睡眠 / Bach1 / Mitf / ビリルビン / 酸素 / 発現制御 / 換気・血流比 / 気道神経上皮小体 / 癌 / 小細胞肺がん / 換気血流不均等 / イオンチャネル / ヘムオキゲナ-ゼ / Heme / Heme Oxygenase / Gene Expression / Transcription Factor / Stress / ポルフィリン症 / ヘム代謝調節 / 先天異常 / 鉄芽球性貧血 / コプロポルフィリノーゲンオキシダーゼ / ウロポルフィリノーゲンデカルボキシラーゼ / δ-アミノレブリン酸脱水酵素 / δ-アミノレブリン酸合成酵素 / ヘム代謝 / Porphyria / Regulation of Heme Metabolism / Genetic Diorder / メラニン合成 / ヘム分解 / melanin biosynthesis / heme catabolism / 小眼球症 / TRF-1 / TRF-2 / tyosinase / microphthalmia / 網膜 / melanocyte / retina / 小眼球症関連転写因子 / 赤血球 / oxygen sensor / ventilatory response / erythrocyte … More Except Principal Investigator MITF / ヘムオキシゲナーゼ / 転写因子 / Prostaglandin D synthase / サイレンサー / Wnt / ヘム / メラノサイト / melanocytes / 遺伝子異常 / 酵素欠損症 / 代謝異常症 / 白皮症 / メラニン / 熱ショック / 細胞分化 / tyrosinase / gene expression / microphthalmia / transcriptional regulation / TRP-2 / MITFアイソフォーム / アミノレブリン酸合成酵素 / BPA / アドレノメデュリン / 低酸素 / グリオブラストーマ / Nitric Oxide / Heme oxygenase / Adrenomedullin / Hypoxia / Bach1 / Nrf2 / heme oxygenase / 分化 / OTX2 / LEF1 / transcription factor / SOX10 / Endothelin / DNA methylation / RNA interference / Prostaglandin D2 / 平滑筋細胞 / 興奮性受容体作動性チャネル / チスカリン受容体 / アドレナリン受容体 / 過分極性K電流 / 細胞内Ca制御 / コンダクタンス減少性脱分極 / チロシナ-ゼ / エンハンサー領域 / チロジナーゼ / プロモーター / 熱ショック蛋白質 / 遺伝子発現 / ストレス応答 / ヘムオキシゲナーゼ / 種差 / カドミウム / ストレス / ヘム代謝 / MIFT / melnin / Waardenburg syndrome / c-kit / Sox 10 / ヒト結腸 / C-Kit / LEF-1 / 分子病態学 / 鉄芽球性貧血 / 翻訳後修飾 / SUMO / 赤芽球 / 先天性白皮症 / チロシナーゼ / 遺伝性疾患 / がん熱中性子捕捉療法 / in vivo遺伝子導入 / 悪性黒色腫 / トランスフェリン複合体ベクター / エレクトロポレーション / BPAメラニンモノマー錯体 / キトサンナノパーティクル / 遺伝子導入 / cancer boron neutron capture therapy / in vivo gene-transfer / malignant melanoma / transferrin-conjugate gene vector / electroporation / isoform of MITF / melanin monomer complex / 脳 / 一酸化窒素 / 一酸化炭素 / 酸化ストレス / アドレナデュリン / heme Oxygenase / NO / carbon monoxide / adrenomedullin / cytokine / glioblastoma / hypoxia / Brain / Carbon monoxide / Oxidative Stress / Glioblastoma / 転写 / 腫瘍 / 血管内皮 / ウロコルチン / オレキシン / 血管内比 / アドレノメデジュリン / 内皮細胞 / Transcription / Tumor / Vascular endothelial cell / Urocortin / Orexin / 金属ポルフィリン / 発現調節 / 造血細胞 / NO供与体 / ポルフィリン / ヘムオキシゲナーゼ-1 / 低酸素応答 / 金属 / 白血病発症 / NFE2 / 造血細胞分化 / metalloporthyrin / transcriptional control / cell differentiation / erythroid cells / ドーパクロムトートメラーゼ / differentiation / DOPAchrome tautomerase / 概日リズム / 換気応答 / Prostaglandin D2 synthase / circadian rhythm / respiratory response / アミルブリン酸合成酵素 / heme / aminolevulinate synthase / メラノーマ / がん抑制遺伝子 / 増殖 / melanoma / tumor suppressor gene / growth Less

Post-translational modification of erythroid-specific 5-aminolevulinate synthase and its' role in erythroid differentiation.
- Principal Investigator
  
  FURUYAMA Kazumichi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
肺がんの進展に関与する肺循環血流の制御機構の解明Principal Investigator
- Principal Investigator
  
  柴原茂樹
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
The Regulatory Mechanism of Differentiation and Growth by Prostaglandin D2 in Pigment Cells
- Principal Investigator
  
  TAKEDA Kazuhisa
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
肺がんの発生と進展に関与する肺特異的低酸素応答の分子機構の解明Principal Investigator
- Principal Investigator
  
  柴原茂樹
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Multiple mechanisms for the regulation of heme biosynthesis and catabolism.
- Principal Investigator
  
  FURUYAMA Kazumichi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
肺特異的低酸素応答と換気・血流比維持機構の解明Principal Investigator
- Principal Investigator
  
  柴原茂樹
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
Molecular basis for hypoxic sensing and regulation of ventilatory responsesPrincipal Investigator
- Principal Investigator
  
  SHIBAHARA Shigeki
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
Analysis of the mutant mice for transcription factor Mitf, which exhibit abnormalities of respiratory control and circadian rhythm
- Principal Investigator
  
  TAKEDA Kazuhisa
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
腫瘍の形成と維持を規定する低酸素応答の分子基盤Principal Investigator
- Principal Investigator
  
  柴原茂樹
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
睡眠時無呼吸に対する防御機構としての低酸素応答の分子基盤Principal Investigator
- Principal Investigator
  
  柴原茂樹
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
Analysis of Wnt signal transduction via cAMP responsive element
- Principal Investigator
  
  TAKEDA Kazuhisa
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
網膜色素上皮細胞におけるWntシグナル関連転写因子群の機能発現機構Principal Investigator
- Principal Investigator
  
  柴原茂樹
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Studies on expression of bioactive substances under hypoxia and relation to diseases
- Principal Investigator
  
  TAKAHASHI Kazuhiro
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
Evaluation of toxicities of porphyrin derivatives and its possible application
- Principal Investigator
  
  FUJITA Hiroyoshi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  Hokkaido University
色素細胞分化におけるWntシグナル関連因子とMITFとの機能的相互作用
- Principal Investigator
  
  安元研一
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
マラリアの重症化に関与する宿主因子の分子制御Principal Investigator
- Principal Investigator
  
  柴原茂樹
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
小眼球症関連転写因子MITFの細胞分化における機能的多様性
- Principal Investigator
  
  安元研一
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
腸管筋層における転写因子MITF isoformによるC-KIT発現調節
- Principal Investigator
  
  大井龍司
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pediatric surgery
- Research Institution
  Tohoku University
Molecular basis of the structural and functional multiplicity of microphthalmia-associated transcription factorPrincipal Investigator
- Principal Investigator
  
  SHIBAHARA Shigeki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  TOHOKU UNIVERSITY
個体老化のモデルとしての白髪形成の分子機構の解明Principal Investigator
- Principal Investigator
  
  柴原茂樹
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
Gene Transfer-applied Cancer Boron Neutron Capture Therapy : Expansion of therapeutic applicability
- Principal Investigator
  
  MISHIMA Yutaka
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Kobe University
Heme oxygenase in the brain
- Principal Investigator
  
  TAKAHASHI Kazuhiro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
Molecular mechanisms of pigment cell differentiation.Principal Investigator
- Principal Investigator
  
  SHIBAHARA Shigeki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
ヒトヘムオキシゲナーゼ遺伝子の熱ショックエレメントの機能の抑制
- Principal Investigator
  
  藤田博美
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
神経線維腫症1型の原因遺伝子産物の新しい生理機能の解明Principal Investigator
- Principal Investigator
  
  柴原茂樹
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
Development of a new method for detecting gene expression in a single cell and its medical application.Principal Investigator
- Principal Investigator
  
  SHIBAHARA Shigeki
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
ヒトヘムオキシゲナーゼ遺伝子の熱ショックエレメントの機能の抑制機構
- Principal Investigator
  
  藤田博美
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
アルビニズム(先天性白皮症)の本態に関する分子生物学的研究Principal Investigator
- Principal Investigator
  
  柴原茂樹
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
ヒトヘムオキシゲナーゼ遺伝子の熱ショックエレメントの機能の抑制機構
- Principal Investigator
  
  FUJITA Hiroyoshi
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
Molecular analyzes of heme regulation and its disorders.Principal Investigator
- Principal Investigator
  
  SHIBAHARA Shigeki
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Tohoku University
アルビニズム(先天性白皮症)の本態に関する分子生物学的研究Principal Investigator
- Principal Investigator
  
  柴原茂樹
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
チロシナーゼ陰性型白皮症の病因であるチロシナーゼ遺伝子の異常についての研究
- Principal Investigator
  
  富田靖
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Tohoku University
アルビニズム(先天性白皮症)の本態に関する分子生物学的研究Principal Investigator
- Principal Investigator
  
  柴原茂樹
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
ヒト白血病細胞におけるヘム分解の調節機構Principal Investigator
- Principal Investigator
  
  柴原茂樹
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
チロシナ-ゼ陰性型白皮症の原因であるチロシナ-ゼ遺伝子の異常についての研究
- Principal Investigator
  
  富田靖
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Tohoku University
Transcriptional activation of the human heme oxygenase gene as a cellular defence mechanismPrincipal Investigator
- Principal Investigator
  
  SHIBAHARA Shigeki
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
がん細胞におけるヘムオキシゲナーゼ遺伝子の発現に関する研究Principal Investigator
- Principal Investigator
  
  柴原茂樹
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
平滑筋の化学的興奮性受容体の新しいKイオンチャネルの開閉とその制御機構
- Principal Investigator
  
  猪又八郎
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Tohoku University
チロシナーゼcDNAを用いた先天性白皮症の遺伝生化学的研究
- Principal Investigator
  
  富田靖
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Tohoku University

All 2010 2009 2008 2007 2006 2005 2004

All Journal Article Presentation Book

[Book] Genetic Regulation of the Pigment Cell. The Pigmentary System.Physiology and Pathophysiology,2e(Edited by J.J.Nordlund et al.)2006
- Author(s)
  Takeda K., Shibahara S.
- Total Pages
  1248
- Publisher
  Blackwell Publishing, New York, NY
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390071
[Book] Genetic Regulation of the Pigment Cell. In The Pigmentary System. Physiology and Pathophysiology, 2e (Edited by J. J. Nordlund et al.)2006
- Author(s)
  Takeda K., Shibahara S.
- Total Pages
  1248
- Publisher
  Blackwell Publishing, New York, NY
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390071
[Book] Heme oxygenase and human disease. Heme Oxygenase(Edited by Otterbein L.E.et al.)2005
- Author(s)
  Yamaya M., Shibahara S.
- Total Pages
  417
- Publisher
  Nova Science Publishers, Inc., Carbondale, IL
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390071
[Book] Heme oxygenase and human disease. In Heme Oxygenase (Edited by Otterbein L.E. et al.)2005
- Author(s)
  Yamaya M., Shibahara S.
- Total Pages
  417
- Publisher
  Nova Science Publishers, Inc., Carbondale, IL
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390071
[Book] Heme Oxygenase (Edited by Otterbein L.E. et al.)2005
- Author(s)
  Yamaya M., Shibahara S.
- Total Pages
  417
- Publisher
  Nova Science Publishers, Inc., Carbondale, IL
- Data Source
  KAKENHI-PROJECT-16390071
[Book] Heme Oxygenase (Edited by Otterbein L.E. et al.) (Nova Science Publishers, Inc., Carbondale, IL,)2005
- Author(s)
  Yamaya M., Shibahara S
- Total Pages
  417
- Publisher
  Heme oxygenase and human disease
- Data Source
  KAKENHI-PROJECT-16659079
[Journal Article] Lipocalin-type prostaglandin D synthase as a regulator of the retinoic acid signalling in melanocytes.2010
- Author(s)
  Takeda K, Takahashi NH, Yoshizawa M, Shibahara S.
- Journal Title
  
  J Biochem. vol.148
  
  Pages: 139-148
- NAID
  10027877446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590301
[Journal Article] Hypoxemia induces expression of heme oxygenase-1 and heme oxygenase-2 proteins in the mouse myocardium.2010
- Author(s)
  Han F, Takeda K, Ono M, Date F, Ishikawa K, Yokoyama S, Shinozawa Y, Furuyama K, Shibahara S.
- Journal Title
  
  J Biochem. vol.147
  
  Pages: 143-151
- NAID
  10027873503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590301
[Journal Article] Hypoxia induces erythroid-specific 5-aminolevulinate synthase expression in human erythroid cells through transforming growth factor-beta signaling2009
- Author(s)
  Kaneko K, Furuyama K, Aburatani H, Shibahara S
- Journal Title
  
  FEBS Journal 276
  
  Pages: 1370-1382
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590301
[Journal Article] Hypoxia induces erythroid-specific 5-aminolevulinate synthase expression in human erythroid cells through transforming growth factor-beta signaling.2009
- Author(s)
  Kaneko K, Furuyama K, Aburatani H, Shibahara S.
- Journal Title
  
  FEBS J. vol.276
  
  Pages: 1370-1382
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590301
[Journal Article] Induction of lipocalin-type prostaglandin D synthase in mouse heart under hypoxemia.2009
- Author(s)
  Han F, Takeda K, Ishikawa K, Ono M, Date F, Yokoyama S, Furuyama K, Shinozawa Y, Urade Y, Shibahara S.
- Journal Title
  
  Biochem Biophys Res Commun. vol.385
  
  Pages: 449-453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590301
[Journal Article] Mitf functions as an in ovo regulator for cell differentiation and proliferation during development of the chick RPE.2009
- Author(s)
  Tsukiji N, Nishihara D, Yajima I, Takeda K, Shibahara S, Yamamoto H.
- Journal Title
  
  Dev Biol. vol.326
  
  Pages: 335-346
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590301
[Journal Article] Functional expression of heme oxygenase-1 in human differentiated epidermis and its regulation by cytokines.2009
- Author(s)
  Numata I, Okuyama R, Memezawa A, Ito Y, Takeda K, Furuyama K, Shibahara S, Aiba S.
- Journal Title
  
  J Invest Dermatol. vol.129
  
  Pages: 2594-2603
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590301
[Journal Article] Hypoxia decreases the expression of the two enzymes responsible for producing linear and cyclic tetrapyrroles in the heme biosynthetic pathway2008
- Author(s)
  Vargas PD, Furuyama K, Sassa S, Shibahara S
- Journal Title
  
  FEBS Journal 275
  
  Pages: 5947-5959
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590301
[Journal Article] Hypoxia decreases the expression of the two enzymes responsible for producing linear and cyclic tetrapyrroles in the heme biosynthetic pathway.2008
- Author(s)
  Vargas PD, Furuyama K, Sassa S, Shibahara S.
- Journal Title
  
  FEBS J. vol.75
  
  Pages: 5947-5959
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590301
[Journal Article] Prostaglandin D2 induces heme oxygenase-1 mRNA expression through the DP2 receptor.2008
- Author(s)
  Satarug S, Wisedpanichkij R, Takeda K, Li B, Na-Bangchang K, Moore MR, Shibahara S.
- Journal Title
  
  Biochem Biophys Res Commun. vol.377
  
  Pages: 878-883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590301
[Journal Article] Prostaglandin D2 induces heme oxygenase-1 in human retinal pigment epithelial cells.2008
- Author(s)
  Kuesap J, Li B, Satarug S, Takeda K, Numata I, Na-Bangchang K, Shibahara S.
- Journal Title
  
  Biochem Biophys Res Commun. vol.367
  
  Pages: 413-419
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590301
[Journal Article] A prolyl-hydroxylase inhibitor, ethyl-3,4-dihydroxybenzoate, induces haem oxygenase-1 expression in human cells through a mechanism independent of hypoxia-inducible factor-lalpha.2008
- Author(s)
  Li B, Takeda K, Yokoyama S, Shibahara S.
- Journal Title
  
  J Biochem. vol.144
  
  Pages: 643-654
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590301
[Journal Article] Augmented chemosensitivity in black-eyed white Mitf^<mi-bw> mice, lacking melanocytes.2007
- Author(s)
  Takeda K, Adachi T, Han F, Yokoyama S, Yamamoto H, Hida W, Shibahara S
- Journal Title
  
  J.Biochem.(Tokyo) 141 (3)
  
  Pages: 327-333
- NAID
  10020100508
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390071
[Journal Article] Hypoxia and heme oxygenases: oxygen sensing and regulation of expression2007
- Author(s)
  Shibahara, Shigeki
- Journal Title
  
  Antiox. Redox Signal. 9
  
  Pages: 2209-2225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18012007
[Journal Article] Functional difference of the SOX10 mutant proteins responsible for the phenotypic variability in auditory-pigmentary disorders.2006
- Author(s)
  Yokoyama S, Takeda K, Shibahara S
- Journal Title
  
  J.Biochem.(Tokyo) 140 (4)
  
  Pages: 491-499
- NAID
  10018841466
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390071
[Journal Article] Arg452 substitution of the erythroid-specific 5-aminolaevulinate synthase, a hot spot mutation in X-linked sideroblastic anaemia, does not itself affect enzyme activity.2006
- Author(s)
  Furuyama K, Harigae H, Heller T, Hamel BC, Minder EI, Shimizu T, Kuribara T, Blijlevens N, Shibahara S, Sassa S
- Journal Title
  
  Eur.J.Haematol. 76 (1)
  
  Pages: 33-41
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390071
[Journal Article] Mice with blunted hypoxic ventilatory response are susceptible to respiratory disturbance during hypoxia.2006
- Author(s)
  Adachi T, Ogawa H, Okabe S, Kitamuro T, Kikuchi Y, Shibahara S, Shirato K, Hida W
- Journal Title
  
  Tohoku J.Exp.Med. 209 (2)
  
  Pages: 125-134
- NAID
  10017493065
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390071
[Journal Article] SOX10, in combination with Sp 1, regulates the endothelin receptor type B gene in human melanocyte lineage cells.2006
- Author(s)
  Yokoyama S, Takeda K, Shibahara S
- Journal Title
  
  FEBS J. 273 (8)
  
  Pages: 1805-1820
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390071
[Journal Article] Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines.2006
- Author(s)
  Ding Y, Zhang Y-Z, Furuyama K, Ogawa K, Igarashi K, Shibahara S
- Journal Title
  
  FEBS J. 273 (23)
  
  Pages: 5333-5346
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390071
[Journal Article] Lipocalin-type prostaglandin D synthase as a melanocyte marker regulated by MITF.2006
- Author(s)
  Takeda K, Yokoyama S, Aburatani H, Masuda T; Han F, Yoshizawa M, Yamaki N, Yamamoto H, Eguchi N, Urade Y, Shibahara S
- Journal Title
  
  Biochem.Biophys.Res.Commun. 339 (4)
  
  Pages: 1098-1106
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390071
[Journal Article] Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines : A possible strategy for the maintenance of intracellular heme level.2006
- Author(s)
  Zhang Y, Furuyama K, Kaneko K, Ding Y, Ogawa K, Yoshizawa M, Kawamura M, Takeda K, Yoshida T, Shibahara S
- Journal Title
  
  FEBS J. 273 (14)
  
  Pages: 3136-3147
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390071
[Journal Article] Dynamic changes in expression of heme oxygenases in mouse heart and liver during hypoxia.2005
- Author(s)
  Han F, Takeda K, Yokoyama S, Ueda H, Shinozawa Y, Furuyama K, Shibahara S
- Journal Title
  
  Biochem.Biophys.Res.Commun. 338 (1)
  
  Pages: 653-659
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390071
[Journal Article] Hypoxemia and blunted hypoxic ventilatory responses in mice lacking heme oxygenase-2.2004
- Author(s)
  Adachi T, Ishikawa K, Hida W, Matsumoto H, Masuda T, Date F, Ogawa K, Takeda K, Furuyama K, Zhang Y, Kitamuro T, Ogawa H, Maruyama Y, Shibahara S
- Journal Title
  
  Biochem.Biophys.Res.Commun. 320 (2)
  
  Pages: 514-522
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390071
[Journal Article] Expression of heme oxygenase-1 is repressed by interferon-y and induced by hypoxia in human retinal pigment epithelial cells.2004
- Author(s)
  Udono-Fujimori R, Takahashi K, Takeda K, Furuyama K, Kaneko K, Takahashi S, Tamai M, Shibahara S
- Journal Title
  
  Eur.J.Biochem. 271 (14)
  
  Pages: 3076-3084
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390071
[Presentation] 低酸素刺激によるヘモグロビン合成誘導機構2008
- Author(s)
  金子桐子、古山和道、柴原茂樹
- Organizer
  第81回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20590301
[Presentation] Hypoxia regulates the expression of heme oxygenase-2, a potential oxygen sensor2007
- Author(s)
  Shibahara, Shigeki
- Organizer
  The 5th International Congress Heme Oxygenases 2007
- Place of Presentation
  Krakow, Poland
- Year and Date
  2007-09-08
- Data Source
  KAKENHI-PROJECT-18012007

1. TAKEDA Kazuhisa (30311559)

# of Collaborated Projects: 9 results

# of Collaborated Products: 10 results
2. TAKAHASHI Kazuhiro (80241628)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
3. YASUMOTO Kenichi (90241629)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
4. FURUYAMA Kazumichi (80280874)

# of Collaborated Projects: 7 results

# of Collaborated Products: 14 results
5. 富田靖 (70108512)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
6. FUJITA Hiroyoshi (60142931)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
7. FUKUSHI Yasue (20125644)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. HIDA Wataru (10142944)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
9. 石沢志信 (60158748)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. 鈴木裕行 (10235997)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. 松永純 (20219455)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. SHIBAHARA Shigeki (00154253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. YAMAMOTO Masayuki (50166823)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MISHIMA Yutaka (10073743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. FUKUMORI Yoshinobu (60102927)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. YOSHINO Kazuo (70143964)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. ONO Koji (90122407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. TAMAKI Norihiko (10030941)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. FUJII Yoshiaki (00098146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. IGARASHI Kazuhiko (00250738)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. OGAWA Kazuhiro (30344659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. HARIGAE Hideo (50302146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 猪又八郎 (20004591)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 江刺正喜 (20108468)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 吉沢美季 (50221669)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 大井龍司 (50004734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 仁尾正記 (70228138)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 丸山芳夫 (00133942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 近藤雅雄 (80111110)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 新津洋司郎 (10045502)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. SASSA Shigeru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. HARTMUT Beug

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. SHIBATA Koushi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. SATO Haruo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SHIBAHARA Shigeki 柴原 茂樹

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肺がんの進展に関与する肺循環血流の制御機構の解明Principal Investigator

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肺がんの発生と進展に関与する肺特異的低酸素応答の分子機構の解明Principal Investigator

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肺特異的低酸素応答と換気・血流比維持機構の解明Principal Investigator

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Molecular basis for hypoxic sensing and regulation of ventilatory responsesPrincipal Investigator

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腫瘍の形成と維持を規定する低酸素応答の分子基盤Principal Investigator

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睡眠時無呼吸に対する防御機構としての低酸素応答の分子基盤Principal Investigator

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網膜色素上皮細胞におけるWntシグナル関連転写因子群の機能発現機構Principal Investigator

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SHIBAHARA Shigeki 柴原茂樹