Igarashi Kazuhiko 五十嵐和彦

… Alternative Names

Researcher Number	00250738
Other IDs
Affiliation (Current)	2020: 東北大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2020: 東北大学, 医学(系)研究科(研究院), 教授 2015 – 2020: 東北大学, 医学系研究科, 教授 2016: 東北大学, 医学研究科, 教授 2011 – 2015: 東北大学, 医学(系)研究科(研究院), 教授 2013: 東北大学, 大学院医学系研究科, 教授 … More
Review Section/Research Field	Principal Investigator General medical chemistry / Biological Sciences / Molecular biology / Pathological medical chemistry / General medical chemistry / Medium-sized Section 48:Biomedical structure and function and related fields Except Principal Investigator Biological Sciences / Orthopaedic surgery / General medical chemistry / General medical chemistry … More
Keywords	Principal Investigator 転写因子 / Maf / クロマチン / 赤血球 / LCR / NF-E2 / Bach1 / Bach / 発現制御 / transcription factor … More Except Principal Investigator 転写因子 / Bach1 / 赤血球 / NF-E2 / 細胞分化 / 造血細胞分化 / 遺伝子発現制御 / GATA因子群 / Maf / 幹細胞 / 遺伝子発現 / クロマチン構造 / 細胞内局在 / 分子進化 / 核高次構造 / 核機能可視化 / ICD領域 / ヘム / 転写 / ヘムオキシゲナーゼ / クロマチン / CENP-A / Nrf2 / CML / Bach2 / ABL / PML / エピジェネティクス / NF‐EZ / p45 / 補助転写活性化因子 / 血液細胞 / マスト細胞 / T細胞 / 造血幹細胞 / 骨髄形成 / 遺伝子ターゲティング / GATA転写因子 / アポトーシス / 白血球 / 白血病 / 血球細胞分化 / 発生 / 転写調節因子 / 転写因子ネットワーク / CNCファミリー / bZipドメイン / BTBドメイン / タンパク質間相互作用 / 脊髄損傷 / 酸化ストレス / Back1ノックアウトマウス / 転写制御 / シグナル伝達 / セロトニン / エイコサノイド / 転写活性化キネティクス / 多重レポーター遺伝子 / ポリユビキチン化 / 核外排出抑制 / 核内受容体 / 蛋白質分解 / ユビキチン / ヘムオキシゲナーゼ1 / ヘム生合成調節 / ヘム調節モチーフ / 転写調節 / Nrf3 / コプロポルフィリノーゲンオキシダーゼ / MafK / 5-アミノレブリン酸合成酵素 / Heme / Transcription / Heme-oxygenase 1 / 原子間力顕微鏡(AFM) / ヒストン / カーボンナノチューブ / β-グロビン遺伝子 / エンハンサー / 複製開始因子 / ヌクレオソーム / 原子間力顕微鏡 / ヌクレオソーム再構成 / ヌクレオソームコンパクション / DNAループ / ヌクレオソーム・ポジショニング / ヒストンH1 / DNA・タンパク質相互作用 / カーボンナノチューズ / トポイソメラーゼ / Atomic force microscopy / Chromatin / Histone / Carbon-nano-tube / b-globin gene / Enhancer / Replication Initiator / 金属ポルフィリン / 発現調節 / 造血細胞 / NO供与体 / ポルフィリン / ヘムオキシゲナーゼ-1 / 低酸素応答 / 金属 / 白血病発症 / NFE2 / metalloporthyrin / heme oxygenase / transcriptional control / cell differentiation / erythroid cells / カラーバンディングFISH / 小児白血病 / Color banding FISH method / childhood leukemia / PNL / Imatinib / STI571 / Abl遺伝子 / Rad51 / imatinib / SAM合成酵素 / ヒストンメチル化 / DNAメチル化 / コンディショナルノックダウン / 代謝 / 生命素子 / 翻訳後修飾 / hub metabolite / エネルギー代謝 / 転写環境 / 神経幹細胞 / 翻訳後タンパク質修飾 / タンパク質切断制御 / タンパク質相互作用 / ニューロン分化 / 大脳皮質発生 / タンパク質発現制御 / 筋損傷 / 筋分化 / 生体分子 Less

がん細胞のBACH1依存性を活用した新規治療戦略の開発Principal InvestigatorOngoing
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  Tohoku University
Age-related alterations of hematopoietic stem and progenitor cells due to failure of Bach transcription factorsPrincipal InvestigatorOngoing
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  Tohoku University
Elucidation of epigenetic regulation of erythropoiesis and translation to therapeutic strategyPrincipal InvestigatorOngoing
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  Tohoku University
新規治療の開発を目指したBach1の筋損傷抑制効果の解明Ongoing
- Principal Investigator
  
  奥野洋史
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tohoku University
Development of a new strategy for tumor immunity activationPrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuhiko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
Regulation of erythropoiesis and macrophages by the heme signalPrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuhiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
Novel molecular mechanism collaborating stem neural stem cell mainteinance and differentiation
- Principal Investigator
  
  Katsuyama Yu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  Shiga University of Medical Science
  Tohoku University
Profiling of proteins associated with cell differentiation based on changes in relative abundance and post-translational modification.Principal Investigator
- Principal Investigator
  
  IGARASHI KAZUHIKO
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
Methods rewriting epigenome as the target of methyonine adenosyltransferase II
- Principal Investigator
  
  KATOH Yasutake
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
Regulation of immune cells by heme and its receptors Bach1 and Bach2Principal Investigator
- Principal Investigator
  
  IGARAHI KAZUHIKO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
Coupring mechanism of methionine metabolism and epigenomePrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuhiko
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Regulation of nuclear receptor activity by intracellular signals and ligands
- Principal Investigator
  
  SHIRAKI Takuma
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kinki University
Elucidation of the transcription factor network that regulates cancer-stroma interactionPrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuhiko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
Crosstalk of transcriptional control and energy pathways by hub metabolites
- Principal Investigator
  
  FUKAMIZU Akiyoshi
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
Regulation of immune cell responses by hemePrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuhiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
ES細胞を用いた細胞記憶の改変技術の開発Principal Investigator
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
Regulation of the tumor suppressor p53 by Bach1Principal Investigator
- Principal Investigator
  
  IGARASHI Kazuhiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
Genetic ablation of transcription repressor Bach1 reduces neural tissue damage after spinal cord injury in mice
- Principal Investigator
  
  OZAWA Hiroshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tohoku University
Comparative Analysis of the DECODE Systems in Hematopoiesis and Oxidative Stress ResponsePrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuhiko
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Control of cell proliferation and differentiation by heme bindiny transcription factor BachlPrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuhiko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
Promotion of Studies on the DECODE System in the Genetic Information ExpressionPrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuhiko
- Project Period (FY)
  2004 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
  Hiroshima University
ヘムオキシゲナーゼ1制御因子を標的とした虚血再潅流病態改善薬探索システムの開発Principal Investigator
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Hiroshima University
Regulation of hematopoiesis by the transcription factors Bach1 and Bach2Principal Investigator
- Principal Investigator
  
  IGARASHI Kazuhiko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Hiroshima University
Study of the mechanism of apoptosis and drug resistance in leukemic cells
- Principal Investigator
  
  TASHIRO Satoshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  HIROSHIMA UNIVERSITY
核内オーファンプロテインネットワークの解明
- Principal Investigator
  
  田代聡
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
核内オーファンプロテインネットワークの解明
- Principal Investigator
  
  TASHIRO Satoshi
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
Regulation of cell proliferation ancl apoptcsis by the nansaiption factois Bach1 and Bach2Principal Investigator
- Principal Investigator
  
  IGARASHI Kazuhiko
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima Univeisity Graduate School of Biomedical Sciences
Regulation of gene transcription and nuclear structure by architectural transcription factorsPrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuhiko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  HIROSHIMA UNIVERSITY
Evaluation of toxicities of porphyrin derivatives and its possible application
- Principal Investigator
  
  FUJITA Hiroyoshi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  Hokkaido University
Cytogenetically analysis of congenital abnormality and childhood malignancy using multicolor FISH methods
- Principal Investigator
  
  TASHIRO Satoshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  HIROSHIMA UNIVERSITY
BTB型転写因子によるクロマチン構造と核内構造の共役Principal Investigator
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Hiroshima University
核内オーファンプロテインネットワークの解明Principal Investigator
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
Bachファミリーによる細胞の増殖と死の制御Principal Investigator
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
Regulation of chromatin structures and hematopoietic cell differentiation by architectural transcription factors Bach1 and Bach2Principal Investigator
- Principal Investigator
  
  IGARASHI Kazuhiko
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  General medical chemistry
- Research Institution
  HIROSHIMA UNIVERSITY
Regulation of chromatin structures during hematopoietic cell differentiationPrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuhiko
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  General medical chemistry
- Research Institution
  HIROSHIMA UNIVERSITY
NF-E2関連因子群によるクロマチン構造の制御と造血細胞分化における転写制御機構
- Principal Investigator
  
  小林聡
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
造血細胞分化におけるNF-E2関連因子群の機能
- Principal Investigator
  
  小林聡
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
REGULATION OF CELL PROLIFERATION BY CROSS-TALK OF BACH AND AP-1 TRANSCRIPTION FACTORS.Principal Investigator
- Principal Investigator
  
  IGARASHI Kazuhiko
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  HIROSHIMA UNIVERSITY
BachファミリーとAP-1のクロストークによる細胞増殖・分化の調節機構Principal Investigator
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
グロビン遺伝子LCR結合因子によるクロマチン構造調節機構の解析Principal Investigator
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
転写調節による造血分化制御
- Principal Investigator
  
  仲野徹
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
NF-E2結合配列を介した転写調節機構とその血液細胞分化における役割
- Principal Investigator
  
  KOBAYASHI Akira
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Roles of heme in the regulation of gene expression and cell differentiation of erythroid cells
- Principal Investigator
  
  HAYASHI Norio
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Tohoku University
Nucleosome Structure-Function Relationship : Analyses by using atomic force microscopy
- Principal Investigator
  
  TAKEYASU Kunio
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Molecular biology
- Research Institution
  KYOTO UNIVERSITY
新しい転写因子Bachファミリーと小Maf による細胞増殖分化の調節機構の解析Principal Investigator
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  University of Tsukuba
グロビン遺伝子LCR結合因子によるクロマチン構造調節機構の解析Principal Investigator
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  University of Tsukuba
血球系転写因子NF−E2の活性調節機構の解析
- Principal Investigator
  
  永井正
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
GENETIC CONTROL OF HEMATOPOIETIC CELL DOFFERENTIATIONPrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuhiko
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Molecular biology
- Research Institution
  Tohoku University
  University of Tsukuba
REGULATION OF DIFFERENTIATION BY BACH TRANSCRIPTION FACTORSPrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuhiko
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Tohoku University
  University of Tsukuba
小Maf因子群とCNC転写因子群とによる細胞増殖分化の調節機構の解析Principal Investigator
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  University of Tsukuba
グロビン遺伝子LCRの結合因子によるクロマチン構造調節機構の解析Principal Investigator
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  University of Tsukuba
新しい赤血球転写因子ECHによる転写制御機構の解析Principal Investigator
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Molecular biology
- Research Institution
  University of Tsukuba
転写因子群による赤血球特異的な遺伝子発現制御機序の解析
- Principal Investigator
  
  山本雅之
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  University of Tsukuba
赤血球系転写因子群とMaf関連蛋白質による赤血球分化の制御とその異常の解析Principal Investigator
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
グロビン遺伝子エンハンサーLCRによる活性化クロマチン構造の誘導機構Principal Investigator
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  University of Tsukuba
新しい赤血球特異的転写因子ECHとMaf関連蛋白質との会合による転写制御Principal Investigator
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Molecular biology
- Research Institution
  University of Tsukuba
転写因子群による赤血球特異的な遺伝子発現調節機序の解析
- Principal Investigator
  
  YAMAMOTO Masayuki
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
癌遺伝子mafの関連遺伝子産胸による赤血球系転写因子NF-E2の機能変換Principal Investigator
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
赤血球特異的転写因子NF-E2とMaf関連蛋白質との会合による転写制御Principal Investigator
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Molecular biology
- Research Institution
  Tohoku University

[Book] Epigenetics : Development and Disease2012
- Author(s)
  Kazuhiko Igarashi, et al
- Publisher
  Springer
- Data Source
  KAKENHI-PLANNED-23116003
[Book] 遺伝情報の発現制御～転写機構からエピジェネェティクスまで～2012
- Author(s)
  五十嵐和彦、深水昭吉、山本雅之
- Total Pages
  429
- Publisher
  メディカルサイエンスインターナショナル
- Data Source
  KAKENHI-PROJECT-21249014
[Book] 遺伝情報の発現制御-転写機構からエピジェネティクスまで-2012
- Author(s)
  五十嵐和彦・監訳（Gene Control：David S. Latchman 著）
- Total Pages
  429
- Publisher
  メディカル・サイエンス・インターナショナル
- Data Source
  KAKENHI-ORGANIZER-23116001
[Book] Epigenetics:Dvelopment and Disease2012
- Author(s)
  Igarashi K, Katoh Y.
- Publisher
  Springer
- Data Source
  KAKENHI-PLANNED-23116003
[Book] 転写因子による生命現象解明の最前線2007
- Author(s)
  五十嵐和彦
- Total Pages
  237
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-16088101
[Journal Article] Biophysical characterization of heme binding to the intrinsically disordered region of Bach1.2019
- Author(s)
  Segawa, K., Watanabe-Matsui, M., Tsuda, K., Matsui, T., Shirouzu, M., Igarashi, K. and Murayama, K.
- Journal Title
  
  European Biophysics Journal
  
  Volume: In press
- DOI
  10.1007/s00249-019-01364-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H04021
[Journal Article] Functional Heme Binding to the Intrinsically Disordered C-Terminal Region of Bach1, a Transcriptional Repressor2019
- Author(s)
  Segawa, K., Watanabe-Matsui, M., Matsui, T., Igarashi, K. and Murayama, K.
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 247 Issue: 3 Pages: 153-159
- DOI
  10.1620/tjem.247.153
- NAID
  130007610254
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H04021
[Journal Article] Bach2 Promotes B Cell Receptor-Induced Proliferation of B Lymphocytes and Represses Cyclin-Dependent Kinase Inhibitors.2018
- Author(s)
  Miura Yuichi、Morooka Mizuho、Sax Nicolas、Roychoudhuri Rahul、Itoh-Nakadai Ari、Brydun Andrey、Funayama Ryo、Nakayama Keiko、Satomi Susumu、Matsumoto Mitsuyo、Igarashi Kazuhiko、Muto Akihiko
- Journal Title
  
  The Journal of Immunology
  
  Volume: 200 Pages: 1601863-1601863
- DOI
  10.4049/jimmunol.1601863
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08572, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-18H04021, KAKENHI-PROJECT-16K07108
[Journal Article] Zinc finger-IRF composite elements bound by Ikaros/IRF4 complexes function as gene repression in plasma cell.2018
- Author(s)
  Kyoko Ochiai, Haruka Kondo, Yasunobu Okamura, Hiroki Shima, Yuko Kurokochi, Kazumi Kimura, Ryo Funayama, Takeshi Nagashima, Keiko Nakayama, Katsuyuki Yui, Kengo Kinoshita and Kazuhiko Igarashi
- Journal Title
  
  Blood Advances
  
  Volume: Apr 24;2(8) Pages: 883-894
- DOI
  10.1182/bloodadvances.2017010413
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01295, KAKENHI-PROJECT-16K19026, KAKENHI-PROJECT-17K07278, KAKENHI-PROJECT-18H04021
[Journal Article] Transcription factor IRF8 governs enhancer landscape dynamics in mononuclear phagocyte progenitors2018
- Author(s)
  Kurotaki D, Nakabayashi J, Nishiyama A, Sasaki H, Kawase W, Kaneko N, Ochiai K, Igarashi K, Ozato K, Suzuki Y, Tamura T
- Journal Title
  
  Cell Reports
  
  Volume: 22 Pages: 2628-2641
- DOI
  10.1016/j.celrep.2018.02.048
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15J07928, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-18H04021
[Journal Article] Identification of a novel enhancer/chromatin opening element associated with high-level g-globin gene expression.2018
- Author(s)
  Shen, Y., Bassett, M.L., Gurumurthy, A., Nar, R., Knudson, I. J., Guy, C. R., Perez, A., Mellen, R. W., Ikeda, M., Hossain, M. A., Huang, S., Igarashi, K. and Bungert, J.
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: In press
- DOI
  10.1128/mcb.00197-18
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04021
[Journal Article] Phosphorylation of BACH1 switches its function from transcription factor to mitotic chromosome regulator and promotes its interaction with HMMR2018
- Author(s)
  Li J, Shima H, Nishizawa H, Ikeda M, Brydun A, Matsumoto M, Kato H, Saiki Y, Liu L, Watanabe-Matsui M, Iemura K, Tanaka K, Shiraki T, Igarashi K.
- Journal Title
  
  Biochemical Journal
  
  Volume: 475 Pages: 981-1002
- DOI
  10.1042/bcj20170520
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07108, KAKENHI-PROJECT-16K08573, KAKENHI-PUBLICLY-16H01296, KAKENHI-PROJECT-15H04368, KAKENHI-PROJECT-16J40189, KAKENHI-PROJECT-16K14604, KAKENHI-PROJECT-17K07278, KAKENHI-PROJECT-18H04021
[Journal Article] Infection perturbs Bach2- and Bach1-dependent erythroid lineage ‘choice’ to cause anemia2018
- Author(s)
  Kato H, Itoh-Nakadai A, Matsumoto M, Ishii Y, Watanabe-Matsui M, Ikeda M, Ebina-Shibuya R, Sato Y, Kobayashi M, Nishizawa H, Suzuki K, Muto A, Fujiwara T, Nannya Y, Cazzola M, Ogawa S, Harigae H, Igarashi K
- Journal Title
  
  Nature Immunology
  
  Volume: 19 Pages: 1059-1070
- DOI
  10.1038/s41590-018-0202-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08314, KAKENHI-PROJECT-26221308, KAKENHI-PROJECT-18H04021, KAKENHI-PROJECT-16K07108
[Journal Article] O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF1.2018
- Author(s)
  Sekine Hiroki、Okazaki Keito、Kato Koichiro、Alam M. Morshedul、Shima Hiroki、Katsuoka Fumiki、Tsujita Tadayuki、Suzuki Norio、Kobayashi Akira、Igarashi Kazuhiko、Yamamoto Masayuki、Motohashi Hozumi
- Journal Title
  
  Mol Cell Biol.
  
  Volume: 38 Pages: 00252-18
- DOI
  10.1128/mcb.00252-18
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07278, KAKENHI-PROJECT-17K19680, KAKENHI-PROJECT-17K19916, KAKENHI-PUBLICLY-18H04794, KAKENHI-PROJECT-18H04021, KAKENHI-PROJECT-15H04691, KAKENHI-PROJECT-16H03265, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-16H05922, KAKENHI-PROJECT-17F17116, KAKENHI-PROJECT-17K19508
[Journal Article] Endogenous purification of NR4A2 (Nurr1) identified Poly(ADP-ribose) polymerase 1 as a prime coregulator in human adrenocortical H295R cells.2018
- Author(s)
  Noro, E., Yokoyama, A., Kobayashi, M., Shimada, H., Suzuki, S., Hosokawa, M., Takehara, T., Parvin, R., Shima, H., Igarashi, K. and Sugawara A.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 19 Pages: 1406-1406
- DOI
  10.3390/ijms19051406
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04021, KAKENHI-PROJECT-16H03252, KAKENHI-PROJECT-16K08606
[Journal Article] Inflammatory responses induce an identity crisis of alveolar macrophages, leading to pulmonary alveolar proteinosis2017
- Author(s)
  Ebina-Shibuya R, Matsumoto M, Kuwahara M, Jang KJ, Sugai M, Ito Y, Funayama R, Nakayama K, Sato Y, Ishii N, Okamura Y, Kinoshita K, Kometani K, Kurosaki T, Muto A, Ichinose M, Yamashita M, Igarashi K.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Pages: 18098-18112
- DOI
  10.1074/jbc.m117.808535
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07108, KAKENHI-PROJECT-16K08572, KAKENHI-PROJECT-16K15232, KAKENHI-PROJECT-26221306, KAKENHI-PROJECT-15H02506, KAKENHI-PROJECT-15H04742, KAKENHI-PROJECT-16H05138, KAKENHI-PROJECT-16H05307, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-16H06640, KAKENHI-PROJECT-16K15289, KAKENHI-PROJECT-16K15508, KAKENHI-PROJECT-16K19158
[Journal Article] Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells2017
- Author(s)
  Sato Y, Kato H, Ebina-Shibuya R, Itoh-Nakadai A, Okuyama R, Igarashi K
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 241 Issue: 3 Pages: 175-182
- DOI
  10.1620/tjem.241.175
- NAID
  130005241504
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461686, KAKENHI-PROJECT-15H02506, KAKENHI-PROJECT-16K15227, KAKENHI-PROJECT-17H04240
[Journal Article] Actin Family Proteins in the Human INO80 Chromatin Remodeling Complex Exhibit Functional Roles in the Induction of Heme Oxygenase-1 with Hemin.2017
- Author(s)
  Takahashi Yuichiro、Murakami Hirokazu、Akiyama Yusuke、Katoh Yasutake、Oma Yukako、Nishijima Hitoshi、Shibahara Kei-ichi、Igarashi Kazuhiko、Harata Masahiko
- Journal Title
  
  Front. Genet.
  
  Volume: 8 Pages: 17-17
- DOI
  10.3389/fgene.2017.00017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25850242, KAKENHI-PROJECT-15H02506
[Journal Article] Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2.2017
- Author(s)
  Alam MM, Okazaki K, Nguyen LTT, Ota N, Kitamura H, Murakami S, Shima H, Igarashi K, Sekine H, Motohashi H
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 印刷中 Pages: 7519-7530
- DOI
  10.1074/jbc.m116.773960
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-16K15228, KAKENHI-PROJECT-17K15591, KAKENHI-PROJECT-15H02506
[Journal Article] BACH transcription factors in innate and adaptive immunity.2017
- Author(s)
  Igarashi K, Kurosaki T, Roychoudhuri R.
- Journal Title
  
  Nature Reviews Immunology
  
  Volume: 印刷中 Pages: 437-450
- DOI
  10.1038/nri.2017.26
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221306, KAKENHI-PROJECT-15H02506, KAKENHI-PROJECT-16K15289
[Journal Article] Bach2 represses the AP-1-driven induction of interleukin-2 gene transcription in CD4＋ T cells.2017
- Author(s)
  Jang, F., Lee. H. R., Oh, A. R., Cha, J. Y., Igarashi, K. and Youn J.
- Journal Title
  
  BMB Rep.
  
  Volume: 50 Pages: 472-477
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02506
[Journal Article] Regulatory signatures of liver regeneration distilled by integrative analysis of mRNA, histone methylation, and proteomics.2017
- Author(s)
  Sato, Y., Katoh, Y., Matsumoto, M., Sato, M., Ebina, M., Itoh-Nakadai, A., Funayama, R., Nakayama, K., Unno, M., Igarashi, K.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 印刷中 Pages: 8019-8037
- DOI
  10.1074/jbc.m116.774547
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293059, KAKENHI-PROJECT-16K14664, KAKENHI-PROJECT-15H02506
[Journal Article] Iron-heme-Bach1 axis is involved in erythroblast adaptation to iron deficiency.2017
- Author(s)
  Kobayashi M, Kato H, Hada H, Itoh-Nakadai A, Fujiwara T, Muto A, Inoguchi Y, Ichiyanagi K, Hojo W, Tomosugi N, Sasaki H, Harigae H, Igarashi K.
- Journal Title
  
  Haematologica.
  
  Volume: 102 Pages: 454-465
- DOI
  10.3324/haematol.2016.151043
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293225, KAKENHI-PROJECT-16K08572, KAKENHI-PROJECT-15H02506
[Journal Article] Genetic ablation of Bach1 gene enhances recovery from hyperoxic lung injury in newborn mice via transient upregulation of inflammatory genes.2017
- Author(s)
  Ito M, Nagano N, Arai Y, Ogawa R, Kobayashi S, Motojima Y, Go H, Tamura M, Igarashi K, Dennery PA, NambaF
- Journal Title
  
  Pediatr. Res.
  
  Volume: Epub ahead of print Pages: 926-931
- DOI
  10.1038/pr.2017.17
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21334, KAKENHI-PROJECT-15H02506
[Journal Article] Reductions in the mitochondrial ABC transporter Abcb10 affect the transcriptional profile of heme biosynthesis genes.2017
- Author(s)
  Seguin, A., Takahashi-Makise, N., Yien, Y. Y., Huston, N. C., Whitman, J. C., Musso, G., Wallace, J. A., Bradley, T., Bergonia, H. A., Kafina, M. D., Matsumoto, M., Igarashi, K., Phillips, J. D., Paw, B. H., Kaplan, J., Ward, D. M.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 292 Pages: 16284-16299
- DOI
  10.1074/jbc.m117.797415
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02506
[Journal Article] mTOR-Bach2 cascade controls cell cycle and class switch recombination2017
- Author(s)
  Tamahara T, Ochiai K, Muto A, Kato Y, Sax N, Matsumoto M, Koseki T, Igarashi K.
- Journal Title
  
  Mol. Cell. Biol.
  
  Volume: 37
- DOI
  10.1128/mcb.00418-17
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07108, KAKENHI-PUBLICLY-16H01295, KAKENHI-PROJECT-15H02506, KAKENHI-PROJECT-15K15771
[Journal Article] Frequent downregulation of BACH2 expression in Epstein-Barr virus-positive diffuse large B-cell lymphoma.2017
- Author(s)
  Noujima-Harada M, Takata K, Miyata-Takata T, Sakurai H, Igarashi K, Ito E, Nagakita K, Taniguchi K, Ohnishi N, Omote S, Tabata T, Sato Y, Yoshino T.
- Journal Title
  
  Cancer Sci.
  
  Volume: 印刷中 Pages: 1071-1079
- DOI
  10.1111/cas.13213
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26253061, KAKENHI-PROJECT-15H02506
[Journal Article] A Bach2-Cebp Gene Regulatory Network for the Commitment of Multipotent Hematopoietic Progenitors2017
- Author(s)
  Itoh-Nakadai, A., Matsumoto, M., Kato, H., Sasaki, J., Uehara, Y., Sato, Y., Ebina-Shibuya, R., Morooka, M., Funayama, R., Nakayama, K., Ochiai, K., Muto, A. and Igarashi, K.
- Journal Title
  
  Cell reports
  
  Volume: 18 Pages: 2401-2414
- DOI
  10.1016/j.celrep.2017.02.029
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H02506, KAKENHI-PROJECT-26293059, KAKENHI-PROJECT-16K14664, KAKENHI-PROJECT-15K18998, KAKENHI-PROJECT-16K08572, KAKENHI-PROJECT-16K07108, KAKENHI-PROJECT-15KK0328
[Journal Article] The transcription factor Bach2 is Phosphorylated at Multiple Sites in Murine B cells but a Single Site Prevents Its Nuclear Localization2016
- Author(s)
  Ando R, Shima H, Tamahara T, Sato Y, Watanabe-Matsui M, Kato H, Sax N, Motohashi H, Taguchi K, Yamamoto M, Nio M, Maeda T, Ochiai K, Muto A, Igarashi K
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 291 Pages: 1826-1840
- DOI
  10.1074/jbc.m115.661702
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23116002, KAKENHI-PLANNED-23116003, KAKENHI-PROJECT-15H02506, KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-25460352, KAKENHI-PROJECT-26670150, KAKENHI-PROJECT-25291042, KAKENHI-WRAPUP-16H01688, KAKENHI-PROJECT-16J40189
[Journal Article] Charge-state-distribution analysis of Bach2 intrinsically disordered heme binding region2016
- Author(s)
  T. Suenaga, M. Watanabe-Matsui, H. Shima, T. Matsui, M. Ikeda-Saito, K. Igarashi, K. Murayama
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 160 Pages: 291-298
- DOI
  10.1093/jb/mvw035
- NAID
  40021012802
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H00912, KAKENHI-PROJECT-15H02506, KAKENHI-PROJECT-16J40189, KAKENHI-PROJECT-15K05555
[Journal Article] Epigenetic Regulation of the Blimp-1 Gene (Prdm1) in B Cells Involves Bach2 and Histone Deacetylase 32016
- Author(s)
  Tanaka H
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 291 Pages: 6316-6330
- DOI
  10.1074/jbc.m116.713842
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12203, KAKENHI-PLANNED-23116003, KAKENHI-PUBLICLY-26114723, KAKENHI-PROJECT-15H02506, KAKENHI-PROJECT-25460351, KAKENHI-PROJECT-25460352, KAKENHI-PROJECT-25650014, KAKENHI-PROJECT-26281020, KAKENHI-PROJECT-15K07164, KAKENHI-PROJECT-26251004, KAKENHI-PROJECT-16K14675
[Journal Article] Multifunctional human transcriptional coactivator protein PC4 is a substrate of Aurora kinases and activates the Aurora enzymes.2016
- Author(s)
  Dhanasekaran, K., Kumari, S., Boopathi, R., Shima, H., Swaminathan, A., Bachu, M., Ranga, U., Igarashi, K., and Kundu, T.K.
- Journal Title
  
  FEBS J.
  
  Volume: 283 Pages: 268-285
- DOI
  10.1111/febs.13653
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23116003, KAKENHI-PROJECT-15H02506
[Journal Article] The Mediator subunit MED16 transduces NRF2-activating signals into antioxidant gene expression.2016
- Author(s)
  Sekine H, Okazaki K, Ota N, Shima H, Katoh Y, Suzuki N, Igarashi K, Ito M, Motohashi H*, Yamamoto M*
- Journal Title
  
  Mol. Cell. Biol.
  
  Volume: 36 Pages: 407-420
- DOI
  10.1128/mcb.00785-15
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23116002, KAKENHI-PLANNED-26111002, KAKENHI-PUBLICLY-26116702, KAKENHI-PROJECT-15H04691, KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-25460351, KAKENHI-PROJECT-25670157, KAKENHI-PROJECT-26670150, KAKENHI-PROJECT-26460677
[Journal Article] Genomewide approaches for BACH1 target genes in mouse embryonic fibroblasts showed BACH1-Pparg pathway in adipogenesis.2016
- Author(s)
  Matsumoto M, Kondo K, Shiraki T, Brydun A, Funayama R, Nakayama K, Yaegashi N, Katagiri H, Igarashi K.
- Journal Title
  
  Genes Cells
  
  Volume: in press Pages: 553-567
- DOI
  10.1111/gtc.12365
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26830064, KAKENHI-PROJECT-15H02506, KAKENHI-PROJECT-26293059
[Journal Article] BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers.2016
- Author(s)
  Roychoudhuri, R., Clever, D., Li, P., Wakabayashi, Y., Quinn, K.M., Klebanoff, C.A., Ji, Y., Sukumar, M., Eil, R.L., Yu, Z., Spolski, R., Palmer, D.C., Pan, J.H., Patel, S.J., Macallan, D.C., Fabozzi, G., Shih, H.Y., Kanno, Y., Muto, A., Igarashi, K., Leonard, W.J., and Restifo, N.P.
- Journal Title
  
  Nat Immunol.
  
  Volume: 17 Pages: 851-860
- DOI
  10.1038/ni.3441
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02506, KAKENHI-PROJECT-16K08572
[Journal Article] The double knockout of Bach1 and Bach2 in mice reveals shared compensatory mechanisms in regulating alveolar macrophage function and lung surfactant homeostasis2016
- Author(s)
  Ebina-Shibuya, R., Watanabe-Matsui, M., Matsumoto, M., Itoh-Nakadai, A., Funayama, R., Nakayama, K., Muto, A., and Igarashi, K.
- Journal Title
  
  Journal of Biochemistry.
  
  Volume: 160 Pages: 333-334
- DOI
  10.1093/jb/mvw041
- NAID
  40021050454
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02506, KAKENHI-PROJECT-16H06640, KAKENHI-PROJECT-16J40189
[Journal Article] Heme binds to an intrinsically disordered region of Bach2 and alters its conformation.2015
- Author(s)
  M. Watanabe-Matsui, T. Matsumoto, T. Matsui, M. Ikeda-Saito, A. Muto, K. Murayama, and K. Igarashi
- Journal Title
  
  Arch Biochem Biophys.
  
  Volume: 565巻 Pages: 25-25
- DOI
  10.1016/j.abb.2014.11.005
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-24120001, KAKENHI-PROJECT-24350081, KAKENHI-PROJECT-24570175, KAKENHI-PUBLICLY-25109504, KAKENHI-PROJECT-25460352, KAKENHI-PROJECT-25860203, KAKENHI-PROJECT-15H02506
[Journal Article] Synergistic Effect of Neutral Protease and Clostripain on Rat Pancreatic Islet Isolation.2015
- Author(s)
  Dendo M, Maeda H, Yamagata Y, Murayama K, Watanabe K, Imura T, Inagaki A, Igarashi Y, Katoh Y, Ebina M, Fujimori K, Igarashi K, Ohuchi N, Satomi S, Goto M.
- Journal Title
  
  Transplantation
  
  Volume: 99 Pages: 1349-1355
- DOI
  10.1097/tp.0000000000000662
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460351
[Journal Article] The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program.2014
- Author(s)
  Itoh-Nakadai A, Hikota R, Muto A, Kometani K, Matsui-Watanabe M, Sato Y, Kobayashi M, Nakamura A, Miura Y, Yano Y, Tashiro S, Sun J, Ikawa T, Ochiai K, Kurosaki T, and Igarashi K.
- Journal Title
  
  Nat Immunol
  
  Volume: 15 Pages: 1171-1180
- DOI
  10.1038/ni.3024
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23116003, KAKENHI-PROJECT-24689042, KAKENHI-PUBLICLY-25118732, KAKENHI-PROJECT-25460352, KAKENHI-PUBLICLY-26116514, KAKENHI-PROJECT-26293229, KAKENHI-PROJECT-26430114, KAKENHI-PROJECT-26670472
[Journal Article] Wearing red for signaling: the heme-Bach axis in heme metabolism, oxidative stress response and iron immunology.2014
- Author(s)
  Igarashi K, and Watanabe-Matsui M.
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 232 Pages: 229-253
- NAID
  130004460119
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390066
[Journal Article] Heme-Mediated sPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages2014
- Author(s)
  Haldar, M., Kohyama, M., So, A.Y., Kc, W., Wu, X., Briseno, C.G., Satpathy, A.T., Kretzer, N.M., Arase, H., Rajasekaran, N.S., Wang, L., Egawa, T., Igarashi, K., Baltimore, D., Murphy, T.L., and Murphy, K.M.
- Journal Title
  
  Cell.
  
  Volume: 156 Pages: 1223-1234
- DOI
  10.1016/j.cell.2014.01.069
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23116003, KAKENHI-PROJECT-24390066, KAKENHI-PROJECT-24590584, KAKENHI-PROJECT-24659223, KAKENHI-PUBLICLY-25133705, KAKENHI-PROJECT-25670143
[Journal Article] Orchestration of plasma cell differentiation by Bach2 and its gene regulatory network.2014
- Author(s)
  Igarashi K, Ochiai K, Itoh-Nakadai A, and Muto A.
- Journal Title
  
  Immunol. Rev.
  
  Volume: 261 Pages: 116-125
- DOI
  10.1111/imr.12201
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23116003
[Journal Article] Association between BACH2 expression and clinical prognosis in diffuse large B-cell lymphoma.2014
- Author(s)
  Ichikawa, S., Fukuhara, N., Katsushima, H., Takahashi, T., Yamamoto, J., Yokoyama, H., Sasaki, O., Fukuhara, O., Nomura, J., Ishizawa, K., Ichinohasama, R., Muto, A., Igarashi, K., and Harigae, H.
- Journal Title
  
  Canser Science
  
  Volume: in press Pages: 437-444
- DOI
  10.1111/cas.12361
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23116003, KAKENHI-PROJECT-24390066, KAKENHI-PROJECT-24590677, KAKENHI-PROJECT-25460352, KAKENHI-PROJECT-26870038
[Journal Article] Hemopexin-dependent heme uptake via endocytosis regulates the Bach1 transcription repressor and heme oxygenase gene activation2014
- Author(s)
  Hada, H., Shiraki, T., Watanabe-Matsui, M., and Igarashi, K.
- Journal Title
  
  Biochem. Biophys. Acta.
  
  Volume: in press Pages: 2351-2360
- DOI
  10.1016/j.bbagen.2014.02.029
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23116003, KAKENHI-PROJECT-23590324, KAKENHI-PUBLICLY-24116524, KAKENHI-PROJECT-24390066, KAKENHI-PROJECT-25860203
[Journal Article] Bach1 Deficiency and Accompanying Overexpression of Heme Oxygenase-1 Do Not Influence Aging or Tumorigenesis in Mice2014
- Author(s)
  Ota K, Brydun A, Itoh-Nakadai A, Sun J, and Igarashi K
- Journal Title
  
  Oxid Med Cell Longev.
  
  Volume: 2014 Pages: 1-12
- DOI
  10.1155/2014/757901
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390066, KAKENHI-PROJECT-26430114
[Journal Article] Bach1 is critical for the transformation of mouse embryonic fibroblasts by Ras(V12) and maintains ERK signaling.2013
- Author(s)
  Nakanome A, Brydun A, Matsumoto M, Ota K, Funayama R, Nakayama K, Ono M, Shiga K, Kobayashi T, Igarashi K.
- Journal Title
  
  Oncogene
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659168
[Journal Article] Bachl as a regulator of mitosis, beyond its transcriptional function.2013
- Author(s)
  Harusato, A. Naito, Y. Takagi, T. Uchiyama, K. Mizushima, K. Hirai, Y. Higashimura, Y. Katada, K. Handa, O. Ishikawa, T. Yagi, N. Kokura, S. Ichikawa, H. Muto, A. Igarashi, K. Yoshikawa, T.
- Journal Title
  
  Communicative & Integrative Biology
  
  Volume: 19 Pages: 477-479
- DOI
  10.1097/mib.0b013e3182802968
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590705, KAKENHI-PROJECT-22590706, KAKENHI-PROJECT-23790322, KAKENHI-PROJECT-24390066, KAKENHI-PROJECT-25460959, KAKENHI-PUBLICLY-23117702
[Journal Article] BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis.2013
- Author(s)
  Roychoudhuri, R., Hirahara, K., Mousavi, K., Clever, D., Klebanoff, C. A., Bonelli, M., Sciume, G., Zare, H., Vahedi, G., Dema, B., Yu, Z., Liu, H., Takahashi, H., Rao, M., Muranski, P., Crompton, J. G., Punkosdy, G., Muto, A., Igarashi, K., et al.
- Journal Title
  
  Nature
  
  Volume: 498 Pages: 506-510
- DOI
  10.1038/nature12199
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23116003, KAKENHI-PROJECT-24390066, KAKENHI-PROJECT-25460352
[Journal Article] Methionine adenosyltransferase II-dependent histone H3K9 methylation at the COX-2 gene locus2013
- Author(s)
  Kera, Y., Katoh, Y., Ohta, M., Matsumoto, M., Takano-Yamamoto, T. and Igarashi, K.
- Journal Title
  
  J Biol Chem.
  
  Volume: 288 Pages: 12592-13601
- DOI
  10.1074/jbc.m112.429738
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23116003, KAKENHI-PROJECT-23249085, KAKENHI-PROJECT-23790321, KAKENHI-PROJECT-25460351
[Journal Article] BTB and CNC Homolog 1 (Bach1) Deficiency Ameliorates TNBS Colitis in Mice: Role of M2 Macrophages and Heme Oxygenase-1.2013
- Author(s)
  Harusato A, Naito Y, Takagi T, Uchiyama K, Mizushima K, Hirai Y, Higashimura Y, Katada K, Handa O, Ishikawa T, Yagi N, Kokura S, Ichikawa H, Muto A, Igarashi K, Yoshikawa T.
- Journal Title
  
  Inflamm Bowel Dis
  
  Volume: 19 Pages: 740-753
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659168
[Journal Article] Solution structure of clostridial collagenase h and its calcium-dependent global conformation change.2013
- Author(s)
  Ohbayashi N, Matsumoto T, Shima H, Got o M, Watanabe K, Yamano A, Kato Y, Igarashi K, Yamagata Y, Murayama K
- Journal Title
  
  Biophys J.
  
  Volume: 104 Pages: 1538-1545
- DOI
  10.1016/j.bpj.2013.02.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390310, KAKENHI-PROJECT-23790321, KAKENHI-PROJECT-25460351
[Journal Article] BTB and CNC Homolog1 (Bach1) Deficiency Ameliorates TNBS Colitis in Mice: Role of M2 Macrophages and Heme Oxygenase-12013
- Author(s)
  Harusato A, Naito Y, Takagi T, Uchiyama K, Mizushima K, Hirai Y, Higashimura Y, Katada K, Handa O, Ishikawa T, Yagi N, Kokura S, Ichikawa H, Muto A, Igarashi K, Yoshikawa T
- Journal Title
  
  Inflamm Bowel Disease
  
  Volume: 19巻 Pages: 740-753
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659168
[Journal Article] Bach1 is critical for the transformation of mouse embryonic fibroblasts by Ras(V12)and maintains ERK signaling2013
- Author(s)
  Nakanome A, Brydun A, Matsumoto M, Ota K, Funayama R, Nakayama K, Ono M, Shiga K, Kobayashi T, Igarashi K
- Journal Title
  
  Oncogene
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659168
[Journal Article] Bach1 is critical for the transformation of mouse embryonic fibroblasts by Ras(V12) and maintains ERK signaling2013
- Author(s)
  Nakanome A, Brydoun A, Matsumoto M, Ota K, Funayama R, Nakayama K, Ono M, Shiga K, Kobayashi T, Igarashi K
- Journal Title
  
  Oncogene.
  
  Volume: 32 Pages: 3231-3245
- DOI
  10.1038/onc.2012.336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700869, KAKENHI-PLANNED-23116003, KAKENHI-PROJECT-23659791, KAKENHI-PROJECT-24390066, KAKENHI-PROJECT-24700951
[Journal Article] Transforming growth factor-β induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene.2013
- Author(s)
  Okita Y, Kamoshida A, Suzuki H, Itoh K, Motohashi H, Igarashi K, Ogami T, Koinuma D, Kato M.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 288 Pages: 20658-20667
- DOI
  10.1074/jbc.m113.450478
- NAID
  120005316262
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23116002, KAKENHI-PLANNED-23116003, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390066, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-25293092, KAKENHI-PROJECT-25460472, KAKENHI-PROJECT-25640059
[Journal Article] Activation of the SUMO modification system is required for the accumulation of RAD51 at sites of DNA damage.2013
- Author(s)
  Shima H, Suzuki H, Sun J, Kono K, Shi L, Kinomura A, Horikoshi Y, Ikura T, Ikura M, Kanaar R, Igarashi K, Saitoh H, Kurumizaka H, Tashiro S
- Journal Title
  
  Journal Cell Science
  
  Volume: 126 Pages: 5284-5292
- DOI
  10.1242/jcs.133744
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22131004, KAKENHI-PLANNED-23116003, KAKENHI-PROJECT-23501259, KAKENHI-PROJECT-23510061, KAKENHI-PROJECT-23616004, KAKENHI-PROJECT-24390066, KAKENHI-PROJECT-25250023, KAKENHI-PROJECT-25640066
[Journal Article] Bach2 maintains T cells in a naïve state by suppressing effector memory-related genes.2013
- Author(s)
  Tsukumo, S., Unno, M., Muto, A., Takeuchi, A., Kometani, K., Kurosaki, T., Igarashi, K., Saito, T
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 110 Pages: 10735-10740
- DOI
  10.1073/pnas.1306691110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229007, KAKENHI-PLANNED-23116003, KAKENHI-PROJECT-24229004, KAKENHI-PROJECT-24390066, KAKENHI-PROJECT-25460352
[Journal Article] Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function2013
- Author(s)
  Nakamura A, Ebina-Shibuya R, Itoh-Nakadai A, Muto A, Shima H, Saigusa D, Aoki J, Ebina M, Nukiwa T, Igarashi K.
- Journal Title
  
  Journal of exprimental medicine
  
  Volume: 210 Pages: 2191-2204
- DOI
  10.1084/jem.20130028
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22116001, KAKENHI-PLANNED-22116004, KAKENHI-PLANNED-23116003, KAKENHI-PROJECT-24390066, KAKENHI-PROJECT-25460352, KAKENHI-PROJECT-25860021
[Journal Article] Methionine adenosyltransferase II-dependent histone H3K9 methylation at the COX-2 gene locus.2013
- Author(s)
  Kera Y, Katoh Y, Ohta M, Matsumoto M, Takano-Yamamoto T, Igarashi K.
- Journal Title
  
  J Biol Chem
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23116003
[Journal Article] BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint.2013
- Author(s)
  Swaminathan, S., Huang, C., Geng, H., Chen, Z., Harvey, R., Kang, H., Ng, C., Titz, B., Hurtz, C., Sadiyah, M. F., Nowak, D., Thoennissen, G. B., Rand, V., Graeber, T. G., Koeffler, H. P., Carrooll, W. L. Willman, C. L., Hall, A. G., Igarashi, K., Melnick, A. and Muschen, M.
- Journal Title
  
  Nature Medicine
  
  Volume: 19 Pages: 1014-1022
- DOI
  10.1038/nm.3247
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23116003, KAKENHI-PROJECT-24390066
[Journal Article] Transcription-independent role of Bach1 in mitosis2012
- Author(s)
  Jie Li, Takuma Shiraki, Kazuhiko Igarashi
- Journal Title
  
  FEBS Letters
  
  Volume: 586 Pages: 448-454
- DOI
  10.1016/j.febslet.2012.01.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590324
[Journal Article] Bach1 as a regulator of mitosis, beyond its transcriptional function.2012
- Author(s)
  Li, J., Shiraki, T., Igarashi, K.
- Journal Title
  
  Communicative Integrative Biology
  
  Volume: 5 Pages: 1-3
- DOI
  10.4161/cib.21149
- Data Source
  KAKENHI-PROJECT-23590324, KAKENHI-PUBLICLY-24116524
[Journal Article] Transcription-independent role of Bach1 in mitosis through a nuclear exporter Crm1-dependent mechanism2012
- Author(s)
  Li, J., Shiraki, T., Igarashi, K.
- Journal Title
  
  FEBS Lett.
  
  Volume: 586 Pages: 448-454
- URL
  http://www.sciencedirect.com/science/article/pii/S0014579312000610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590324
[Journal Article] Bach1-mediated suppression of p53 is inhibited by p19(ARF) independently of MDM22012
- Author(s)
  Nishizawa H, Ota K, Dohi Y, Ikura T,Igarashi K
- Journal Title
  
  Cancer Science
  
  Volume: 103巻 Pages: 897-903
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659168
[Journal Article] Transcription-independent role of Bach1 in mitosis through a nuclear exporter Crm1-dependent mechanism.2012
- Author(s)
  Li, J., Shiraki, T., Igarashi, K.
- Journal Title
  
  FEBS Lett.
  
  Volume: 586 Pages: 448-454
- DOI
  10.1016/j.febslet.2008.12.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590324, KAKENHI-PUBLICLY-24116524
[Journal Article] Bach1 as a regulator of mitosis, beyond its transcriptional function.2012
- Author(s)
  Li J, Shiraki T, Igarashi K.
- Journal Title
  
  Commun Integr Biol
  
  Volume: 5 Pages: 477-4779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659168
[Journal Article] Bach1 as a regulator of mitosis, beyond its transcriptional function2012
- Author(s)
  Li, J., Shiraki, T. Igarashi, K.
- Journal Title
  
  Communicative & Integrative Biology
  
  Volume: 5 Pages: 1-3
- URL
  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502211/
- Data Source
  KAKENHI-PROJECT-23590324
[Journal Article] Bach1 as a regulat or mitosis, beyond its transcriptional function2012
- Author(s)
  Li J, Shiraki T, Igarashi K
- Journal Title
  
  Commun Integr Biology
  
  Volume: 5巻 Pages: 477-479
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659168
[Journal Article] Bach1-mediated suppression of p53 is inhibited by p19(ARF) independently of MDM2.2012
- Author(s)
  Nishizawa H, Ota K, Dohi Y, Ikura T, Igarashi K.
- Journal Title
  
  Cancer Sci
  
  Volume: 103 Pages: 897-903
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659168
[Journal Article] Identification of senescence-associated genes and their networks under oxidative stress by the analysis of Bach12011
- Author(s)
  Ota K, Dohi Y, Brydun A, Nakanome A, Ito S, Igarashi K
- Journal Title
  
  Antioxid Redox Signal
  
  Volume: 14巻 Pages: 2441-2451
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659168
[Journal Article] Heme regulates B cell differentiation, antibody class switch, and heme oxygenase-1 expression in B cells as a ligand of Bach22011
- Author(s)
  Watanabe-Matsui, M., Muto, A., Matsui, T., Itoh-Nakadai, A., Nakajima, O., Murayama, K., Yamamoto, M., Ikeda-Saito, M., Igarashi, K.
- Journal Title
  
  Blood
  
  Volume: 117巻 Pages: 5438-5448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249014
[Journal Article] Heme regulates B cell differentiation, antibody class switch, and heme oxygenase-1 expression in B cells as a ligand of Bach2.2011
- Author(s)
  Watanabe-Matsui, M., Muto, A., Matsui, T., Itoh-Nakadai, A., Nakajima, O., Murayama, K., Yamamoto, M., Ikeda-Saito, M., Igarashi, K.
- Journal Title
  
  Blood
  
  Volume: (未定印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16088101
[Journal Article] Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch.2010
- Author(s)
  Muto, A., Ochiai, K., Kimura, Y., Itoh-Nakadai, A., Calame, K.L., Ikebe, D., Tashiro, S., Igarashi, K.
- Journal Title
  
  EMBO J.
  
  Volume: 29 Pages: 4048-4061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16088101
[Journal Article] Bach1-dependent and -independent regulation of heme oxygenase-1 in keratinocytes.2010
- Author(s)
  Okada, S., Muto, A., Ogawa, E., Nakanome, A., Katoh, Y., Ikawa, S., Aiba, S., Igarashi, K., Okuyama, R
- Journal Title
  
  J. Biol. Chem (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054028
[Journal Article] Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch2010
- Author(s)
  Muto, A., Ochiai, K., Kimura, Y., Itoh-Nakadai, A., Calame, K. L., Ikebe, D., Tashiro, S. and Igarashi, K.
- Journal Title
  
  EMBO J.
  
  Volume: 29巻 Pages: 4048-4061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249014
[Journal Article] Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch2010
- Author(s)
  Muto, A., Ochiai, K., Kimura, Y., Itoh-Nakadai, A., Calame, K.L., Ikebe, D., Tashiro, S., Igarashi, K.
- Journal Title
  
  EMBO J
  
  Volume: 29 Pages: 4048-4061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249014
[Journal Article] Genetic Ablation of Transcription Repressor Bach1 Reduces Neural Tissue Damage and Improves Locomotor Function after Spinal Cord Injury in Mice2009
- Author(s)
  Kanno H, Ozawa H, Dohi Y, Sekiguchi A, Igarashi K, Itoi E
- Journal Title
  
  J Neurotrauma 26
  
  Pages: 31-39
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591712
[Journal Article] Crystal structure of the Bach1 BTB domain and its regulation of homodimerization.2009
- Author(s)
  Ito, N., Watanabe-Matsui, M., Igarashi, K., Murayama, K
- Journal Title
  
  Genes Cells 14
  
  Pages: 1365-2443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054028
[Journal Article] Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds.2009
- Author(s)
  MacLeod, A. K, McMahon, M., Plummer, S.M., Higgins, L.G., Penning, T.M., Igarashi, K., Hayes JD
- Journal Title
  
  Carcinogenesis 30
  
  Pages: 1571-1580
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054028
[Journal Article] Crystal structure of the Bach1 BTB domain and its regulation of homodimerization2009
- Author(s)
  Ito N., Watanabe-Matsui M., Igarashi K., and Murayama K
- Journal Title
  
  Genes Cells 14
  
  Pages: 1365-2443
- Data Source
  KAKENHI-PROJECT-19390068
[Journal Article] Genetic Ablation of Transcription Repressor Bach1 Reduces Neural Tissue Damage and Improves Locomotor Function after Spinal Cord Injury in Mice2009
- Author(s)
  Kanno H, Ozawa H, Dohi Y, Sekiguchi A, Igarashi K, Itoi E.
- Journal Title
  
  J Neurotrauma 26
  
  Pages: 31-39
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591712
[Journal Article] Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin.2008
- Author(s)
  Dohi, Y., Ikura, T., Hoshikawa, Y., Katoh, Y., Ota, K., Nakanome, A., Muto, A., Omura, S., Ohta, T., Ito, A., Yoshida, M., Noda, T., Igarashi, K
- Journal Title
  
  Nature Struct. Mol. Biol 15
  
  Pages: 1246-1254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054028
[Journal Article] Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin2008
- Author(s)
  Dohi, Y., Ikura, T., Hoshikawa, Y., Katoh, Y., Ota, K., Nakanome, A., Muto, A., Omura, S., Ohta, T., Ito, A., Yoshida, M., Noda, T., and Igarashi, K
- Journal Title
  
  Nature Struct. Mol. Biol 15
  
  Pages: 1246-1254
- Data Source
  KAKENHI-PROJECT-19390068
[Journal Article] Regulation of the plasma cell transcription factor Blimp-1 gene by Bach2 and Bcl6.2008
- Author(s)
  Ochiai, K., Muto, A., Tanaka, H., Takahashi, S., Igarashi, K
- Journal Title
  
  Int. Immunol 20
  
  Pages: 453-460
- NAID
  10021240257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054028
[Journal Article] Bach1 repression of Ferritin and thioredoxin reductase1 is heme-sensitive in cells and in vitro, and coordinates expression with heme oxygenase1, beta-globin and NADP(H) quinone(oxido)reductase12007
- Author(s)
  Hintze, K.J., Katoh, Y., Igarashi, K., and Theil, E.C
- Journal Title
  
  J. Biol. Chem 282
  
  Pages: 34365-34371
- Data Source
  KAKENHI-PROJECT-19390068
[Journal Article] Heme induces ubiquitination and degradation of the transcription factor Bach1.2007
- Author(s)
  Zenke-Kawasaki, Y., Dohi, Y., Katoh, Y., Ikura, T., Ikura, M., Asahara, T., Tokunaga, F., Iwai, K., Igarashi, K
- Journal Title
  
  Mol. Cell. Biol 27
  
  Pages: 6962-6971
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054028
[Journal Article] Architecture and dynamics of the transcription factor network that regula B-to-plasma cell differentiation.2007
- Author(s)
  Igarashi, K. et al.
- Journal Title
  
  J. Biochem. (in press)
- Data Source
  KAKENHI-PROJECT-16088101
[Journal Article] Heme induces ubiquitination and degradation of the transcription factor Bach12007
- Author(s)
  Zenke-Kawasaki, Y., Dohi, Y., Katoh, Y., Ikura, T., Ikura, M., Asahara, T., Tokunaga, F., Iwai, K., and Igarashi, K
- Journal Title
  
  Mol. Cell. Biol 27
  
  Pages: 6962-6971
- Data Source
  KAKENHI-PROJECT-19390068
[Journal Article] Architecture and dynamics of the transcription factor network that regulates B-to-plasma cell differentiation.2007
- Author(s)
  Igarashi, K. et al.
- Journal Title
  
  J. Biochem. (in press)
- NAID
  10020098307
- Data Source
  KAKENHI-PROJECT-17054028
[Journal Article] Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells.2006
- Author(s)
  Ochiai, K., Katoh, Y., Ikura, T., Hoshikawa, Y., Noda, T., Karasuyama, H., Tashiro, S., Muto, A., Igarashi, K
- Journal Title
  
  J. Biol. Chem 281
  
  Pages: 38226-38234
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054028
[Journal Article] The heme-Bach1 pathway in the regulation of oxidative stress response and erythroid differentiation.2006
- Author(s)
  Igarashi, K., et al.
- Journal Title
  
  Antioxid. Redox Signal. 8
  
  Pages: 107-118
- Data Source
  KAKENHI-PROJECT-17390080
[Journal Article] The heme-Bach1 pathway in the regulation of oxidative stress response and erythroid differentiation.2006
- Author(s)
  Igarashi, K., Sun, J.
- Journal Title
  
  Antioxid. Redox Signal. 8
  
  Pages: 107-118
- Data Source
  KAKENHI-PROJECT-17054028
[Journal Article] Effects of genetic ablation of bach1 upon smooth muscle cell proliferation and atherosclerosis after cuff injury.2005
- Author(s)
  Omura, S., Suzuki, H., Toyofuku, M., Ozono, R., Kohno, N., Igarashi, K.
- Journal Title
  
  Genes Cells 10
  
  Pages: 277-285
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13214069
[Journal Article] Effects of genetic ablation of bach1 upon smooth muscle cell proliferation and atherosclerosis after cuff injury.2005
- Author(s)
  Omura, S., Suzuki, H., Toyofuku, M., Ozono, R., Kohno, N., Igarashi, K
- Journal Title
  
  Genes Cells 10
  
  Pages: 277-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17054028
[Journal Article] The transcriptional programme of antibody class switching involves the repressorBach2.2004
- Author(s)
  Muto, A., Tashiro, S., Nakajima, O., Hoshino, H., Takahashi, S., Sakoda, E., Ikebe, D., Yamamoto, M., Igarashi, K.
- Journal Title
  
  Nature 429
  
  Pages: 566-571
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13214069
[Journal Article] Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network.2004
- Author(s)
  Sun, J., Brand, M., Zenke, Y., Tashiro, S., Groudine, M., Igarashi, K.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 101
  
  Pages: 1461-1466
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13214069
[Journal Article] Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1.2004
- Author(s)
  Suzuki, H., Tashiro, S., Hira, S., Sun, J., Yamazaki, C., Zenke, Y., Ikeda-Saito, M., Yoshida, M., Igarashi, K.
- Journal Title
  
  EMBO J. 23
  
  Pages: 2544-2553
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13214069
[Journal Article] Repression of PML nuclear body-associated transcription by oxidative stress-activated Bach2.2004
- Author(s)
  Tashiro, S., Muto, A., Tanimoto, K., Tsuchiya, H., Suzuki, H., Hoshino, H., Yoshida, M., Walter, J., Igarashi, K.
- Journal Title
  
  Mol. Cell. Biol. 24
  
  Pages: 3473-3484
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13214069
[Journal Article] Activation of Maf/AP-1 repressor Bach2 by oxidative stress promotes apoptosis and its interaction with PML nuclear bodies.2002
- Author(s)
  Muto, A., Tashiro, S., Tsuchiya, H., Kume, A., Kanno, M., Ito, E., Yamamoto, M., Igarashi, K.
- Journal Title
  
  J.Biol.Chem. 277
  
  Pages: 20724-20733
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13214069
[Journal Article] Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene.2002
- Author(s)
  Sun, J., Hoshino, H., Takaku, K., Nakajima, O., Muto, A., Suzuki, H., Tashiro, S., Takahashi, S., Shibahara, S., Alain, J., Taketo, M.M., Yamamoto, M., Igarashi, K.
- Journal Title
  
  EMBO J. 21
  
  Pages: 5216-5224
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13214069
[Journal Article] Heme mediates de-repression of Maf recognition element through direct binding to transcription repressor Bach1.2001
- Author(s)
  Ogawa, K., Sun, J., Taketani, S., Nakajima, O., Nishitani, C., Sassa, S., Hayashi, N., Yamamoto, M., Shibahara, S., Fujita, H., Igarashi, K.
- Journal Title
  
  EMBO J. 20
  
  Pages: 2835-2843
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13214069
[Journal Article] Molecular cloning and functional characterization of a new CNC family transcription factor Nrf31999
- Author(s)
  Kobayashi, A., Itoh, E., Toki, T., Takahashi, S-i, Igarashi, K., Hayashi, N., Yamamoto, M.
- Journal Title
  
  J.Biol.Chem. 274
  
  Pages: 6443-6452
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10480163
[Journal Article] Molecular cloning and functional characterization of a new CNC family transcription factor Nrf3.1999
- Author(s)
  Kobayashi, A., Itoh, E., Toki, T., Takahashi, S-i, Igarashi, K., Hayashi, N., Yamamoto, M.
- Journal Title
  
  J. Biol. Chem. 274
  
  Pages: 6443-6452
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10480163
[Journal Article] Regulation of NF-E2 activity in erythroleukemia cell differentiation.1998
- Author(s)
  Nagai, T., Igarashi, K., Akasaka, J., Furuyama, K., Fujita, H., Hayashi, N., Yamamoto, M., Sassa, S.
- Journal Title
  
  J. Biol. Chem. 273
  
  Pages: 5358-5365
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10480163
[Journal Article] Regulation of NF-E2 activity in erythroleukemia cell differentiation1998
- Author(s)
  Nagai, T., Igarashi, K., Akasaka, J., Furuyama, K., Fujita, H., Hayashi, N., Yamamoto, M., Sassa, S.
- Journal Title
  
  J.Biol.Chem. 273
  
  Pages: 5358-5365
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10480163
[Patent] 国際特許2019
- Inventor(s)
  五十嵐和彦、加藤浩貴、石井悠翔、グエン　チ　ロン、張替秀郎
- Industrial Property Rights Holder
  東北大学
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-20K20382
[Patent] 抗リン酸化Bach2抗体および抗腫瘍免疫活性化剤のスクリーニング方法2015
- Inventor(s)
  五十嵐和彦、武藤、落合、島、安藤、佐藤（好）、玉原、佐藤（勇）
- Industrial Property Rights Holder
  国立大学法人東北大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-219945
- Filing Date
  2015-11-09
- Data Source
  KAKENHI-PROJECT-15H02506
[Presentation] Gene regulatory network for hematopoietic stem and progenitor differentiation2019
- Author(s)
  Igarashi K, Kato H, Harigae H.
- Organizer
  International Symposium on Epigenome
- Invited
- Data Source
  KAKENHI-PROJECT-18H04021
[Presentation] Influence of Bach2 expression levels on activated-B cell fate decision2018
- Author(s)
  Akihiko Muto, Nicolas Sax, Shuto Fushimi, Mitsuyo Matsumoto, Kazuhiko Igarashi
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18H04021
[Presentation] エピゲノム-代謝クロストークによる細胞応答の制御2018
- Author(s)
  五十嵐和彦
- Organizer
  第54回インスリン研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18H04021
[Presentation] RNA methylation as a crossroad of metabolism and epigenetics.2018
- Author(s)
  Igarashi K, Shima H.
- Organizer
  Indo-Japan Conference on Epigenetics and Human Disease.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04021
[Presentation] 造血幹細胞分化を制御する転写因子ネットワークとその病態2018
- Author(s)
  五十嵐和彦
- Organizer
  広島腫瘍セミナー2018
- Invited
- Data Source
  KAKENHI-PROJECT-18H04021
[Presentation] TBK1による転写抑制因子Bach2の調節機構の解明2018
- Author(s)
  角屋駿、松井（渡部）美紀、武藤哲彦、島弘季、松本光代、五十嵐和彦
- Organizer
  第91回日本生化学学会
- Data Source
  KAKENHI-PROJECT-18H04021
[Presentation] 形質細胞分化におけるヘムシグナルと天然変性タンパク質2018
- Author(s)
  松井（渡部）美紀、角屋駿、島弘季、武藤哲彦、松本光代、白水美香子、村山和隆、五十嵐和彦
- Organizer
  第91回日本生化学学会
- Data Source
  KAKENHI-PROJECT-18H04021
[Presentation] S-アデノシルメチオニン（SAM）の地産地消機構とその意義2016
- Author(s)
  五十嵐　和彦
- Organizer
  日本薬学会第136年会
- Place of Presentation
  神奈川県横浜市　パシフィコ横浜
- Year and Date
  2016-03-28
- Invited
- Data Source
  KAKENHI-ORGANIZER-23116001
[Presentation] 代謝経路とエピジェネティクス制御系のクロストークとストレス応答2016
- Author(s)
  五十嵐和彦
- Organizer
  第57回日本心身医学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-06-05
- Invited
- Data Source
  KAKENHI-PROJECT-15H02506
[Presentation] Heme regulates protein interaction of Bach2 by binding to its intrinsically disordered region2016
- Author(s)
  五十嵐和彦
- Organizer
  9th International Conference on Heme Oxygenase
- Place of Presentation
  Porcine Institute（チェコ共和国）
- Year and Date
  2016-09-17
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02506
[Presentation] Inner myeloidの遺伝子制御ネットワークとその環境応答機構2016
- Author(s)
  五十嵐和彦
- Organizer
  日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-09-26
- Invited
- Data Source
  KAKENHI-PROJECT-15H02506
[Presentation] local synthesis of S-adenosylmethionine for local consumption, version 2: methylation of chromatin and beyond.2016
- Author(s)
  五十嵐和彦
- Organizer
  転写代謝システム国際シンポジウム
- Place of Presentation
  東京大学（東京都文京区）
- Year and Date
  2016-02-17
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23116003
[Presentation] ヘムは天然変性タンパク質Bach2のタンパク質間相互作用を制御する2015
- Author(s)
  渡部-松井美紀, 島弘季, 五十嵐和彦, 村山和隆
- Organizer
  第15回日本蛋白質科学学会
- Place of Presentation
  徳島市あわぎんホール（徳島県徳島市）
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-15H02506
[Presentation] S-アデノシルメチオニン（SAM）の核内産生機構とそのエピゲノム制御における役割2015
- Author(s)
  五十嵐和彦、蝦名真行、加藤恭丈
- Organizer
  第26回同人化学フォーラム
- Place of Presentation
  熊本ホテルキャッスル、熊本県・熊本市
- Year and Date
  2015-11-13
- Data Source
  KAKENHI-PROJECT-25460351
[Presentation] Heme regulates protein-protein interaction of transcription factor Bach22015
- Author(s)
  Miki Matsui, Kazutaka Murayama, Toshitaka Matsui, Masao Ikeda-Saito, Kazuhiko Igarash.
- Organizer
  2015環太平洋国際化学会議（PACIFICHEM2015)
- Place of Presentation
  ハワイコンベンションセンター（アメリカ）
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02506
[Presentation] Local production of S-adenosylmethionine for local consumption to promote and to regulate methylation of chromatin and beyond.2015
- Author(s)
  五十嵐和彦
- Organizer
  BMB2015（第38回日本分子生物学会年会、第88回日本生化学会大会合同大会）
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PLANNED-23116003
[Presentation] Charge-state-distribution analysis of Bach2 intrinsically disordered heme binding region2015
- Author(s)
  末永知史, 渡部-松井美紀, 島弘季, 五十嵐和彦, 村山和隆
- Organizer
  第53回日本生物物理学会
- Place of Presentation
  金沢大学（石川県金沢市）
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-15H02506
[Presentation] S-アデノシルメチオニンの核内産生機構とそのエピゲノム制御における役割2015
- Author(s)
  五十嵐和彦
- Organizer
  第26回フォーラム・イン・ドージン
- Place of Presentation
  熊本ホテルキャッスル（熊本県熊本市）
- Year and Date
  2015-11-13
- Invited
- Data Source
  KAKENHI-PLANNED-23116003
[Presentation] S-アデノシルメチオニン合成酵素のクロマチンRNA制御における機能と肝再生におけるクロマチン転写ネットワーク2015
- Author(s)
  五十嵐和彦
- Organizer
  長崎医学会特別講演
- Place of Presentation
  長崎大学大学院医歯薬学総合研究科（長崎県長崎市）
- Year and Date
  2015-09-18
- Invited
- Data Source
  KAKENHI-PLANNED-23116003
[Presentation] Nuclear localization of methionine adenosyltransferase II and its function in B cell response.2014
- Author(s)
  Kazuhiko Igarashi
- Organizer
  17th Chromatin Assembly Meeting
- Place of Presentation
  Bangalore, India
- Invited
- Data Source
  KAKENHI-PLANNED-23116003
[Presentation] The heme-Bach1 pathway regulates the adaptive erythropoiesis under iron deficiency.2014
- Author(s)
  五十嵐和彦
- Organizer
  第87回日本生化学会大会シンポジウム「鉄生化学の新しい潮流」
- Place of Presentation
  京都府京都市　国立京都国際会館
- Year and Date
  2014-10-16
- Data Source
  KAKENHI-ORGANIZER-23116001
[Presentation] SAM合成酵素の核内局在によるエピゲノムの制御2014
- Author(s)
  五十嵐和彦
- Organizer
  第二回がんと代謝研究会
- Place of Presentation
  東京理科大学葛飾キャンパス（東京都葛飾区）
- Year and Date
  2014-07-10
- Invited
- Data Source
  KAKENHI-PLANNED-23116003
[Presentation] Heme as a signaling molecule for globin gene regulation and iron homeostasis2013
- Author(s)
  五十嵐和彦
- Organizer
  Cold Spring Harbor Laboratory Meeting Metabolic Sgnaling & Disease:From Cell to Ofganism“
- Place of Presentation
  米国　Cold Spring Harbor Laboratory
- Data Source
  KAKENHI-ORGANIZER-23116001
[Presentation] Demarcation of B and myeloid cells by the heme-binding transcription repressors Bach1 and Bach2.2013
- Author(s)
  A.Itoh-Nakadai., Y.Miura., A.Muto., K.Igarashi.
- Organizer
  Cell Symposia Immunometabolism:from Mechanisms to Therapy
- Place of Presentation
  Sheraton Centre Tronto Hotel, Canada
- Data Source
  KAKENHI-PROJECT-24390066
[Presentation] Multiple metabolic pathways regulate PPARg in multiple ways2013
- Author(s)
  Shiraki, T., Morikawa, K., Igarashi, K.
- Organizer
  CSHL meeting
- Place of Presentation
  Cold Spring Harbor Laboratory, NY, USA
- Data Source
  KAKENHI-PROJECT-23590324
[Presentation] Heme as a signaling molecule for globin gene regulation and iron homeostasis.2013
- Author(s)
  M.Kobayashi., H.Hada., A.Muto.,H.Harigae. K.Igarashi.
- Organizer
  Cold Spring Harbor Laboratory Meeting Metabolic Sgnaling & Disease: From Cell to Ofganism
- Place of Presentation
  Cold Spring Harbor Laboratory, U.S.A.
- Invited
- Data Source
  KAKENHI-PROJECT-24390066
[Presentation] Heme as a signaling molecule for globin gene regulation and iron homeostasis.2013
- Author(s)
  M.Kobayashi., H.Hada., A.Muto.,H.Harigae. K.Igarashi.
- Organizer
  Cold Spring Harbor Laboratory Meeting Metabolic Sgnaling & Disease:From Cell to Ofganism
- Place of Presentation
  Cold Spring Harbor Laboratory, U.S.A.
- Invited
- Data Source
  KAKENHI-PLANNED-23116003
[Presentation] メチオニンアデノシル転移酵素の細胞内局在と制御機構2013
- Author(s)
  加藤恭丈、森野杏子、石山駿、齋藤維友、槙野絵里子、島弘季、五十嵐和彦
- Organizer
  第７回日本エピジェネティクス研究会年会
- Place of Presentation
  奈良県新公会堂
- Data Source
  KAKENHI-PROJECT-25460351
[Presentation] メチオニンアデノシル転移酵素（MATII）の細胞内局在2013
- Author(s)
  石山駿、加藤恭丈、森野杏子、槙野絵里子、五十嵐和彦
- Organizer
  第36回分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-25460351
[Presentation] 転写因子―エピゲノムネットワークによる遺伝情報のプログラミング2013
- Author(s)
  五十嵐和彦
- Organizer
  日本人類遺伝学会
- Place of Presentation
  江陽グランドホテル（宮城県仙台市）
- Invited
- Data Source
  KAKENHI-PLANNED-23116003
[Presentation] Regulation of B cell activation and differentiation by methionine adenosyltransferase II.2013
- Author(s)
  Kazuhiko Igarashi
- Organizer
  International Symposium on Transcription and Metabolism
- Place of Presentation
  淡路夢舞台国際会議場（兵庫県淡路市）
- Invited
- Data Source
  KAKENHI-PLANNED-23116003
[Presentation] Multiple metabolic pathways regulate PPARγ in multiple ways2013
- Author(s)
  Shiraki, T., Morikawa, K., Igarashi, K.
- Organizer
  CSHL meeting 2013　“Metabolic signaling & Disease: From cell to organism”
- Place of Presentation
  コールドスプリングハーバー研究所
- Data Source
  KAKENHI-PROJECT-23590324
[Presentation] Hemopexin-dependent heme uptake through endocytosis regulates Bach1 transcriptional activity of cellular stress responses.2013
- Author(s)
  H.Hada., T.Shiraki.,M.Watanabe-Matsui.,K.Igarashi.
- Organizer
  Cold Spring Harbor Laboratory Meeting Metabolic Sgnaling & Disease: From Cell to Ofganism
- Place of Presentation
  Cold Spring Harbor Laboratory, U.S.A.
- Data Source
  KAKENHI-PROJECT-24390066
[Presentation] メチオニンアデノシル転移酵素（MATII）によるエピジェネティックなCOX-2遺伝子発現制御機構2013
- Author(s)
  解良洋平、加藤恭丈、太田嶺人、松本光代、山本ー高野照子、五十嵐和彦
- Organizer
  第７回日本エピジェネティクス研究会年会
- Place of Presentation
  奈良県新公会堂
- Data Source
  KAKENHI-PROJECT-25460351
[Presentation] 組換えヘモペキシンを用いた細胞外ヘムによる遺伝子制御機構の解明2012
- Author(s)
  羽田浩士、白木琢磨、松井美紀、五十嵐和彦
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-23590324
[Presentation] One receptor senses two ligands; the nuclear receptor PPARg monitors multiple cellular metabolism2012
- Author(s)
  Shiraki, T., Morikawa, K., Igarashi, K.
- Organizer
  Metabolism, Diet and Disease
- Place of Presentation
  Georgetown University Hotel and Conference Center, Washington DC, USA
- Data Source
  KAKENHI-PROJECT-23590324
[Presentation] One receptor senses two ligands; the nuclear receptor PPARγ monitors multiple cellular metabolism2012
- Author(s)
  Shiraki T., Morikawa K., and Igarashi K.
- Organizer
  Metabolism, Diet and Disease
- Place of Presentation
  Washington DC（米国）
- Data Source
  KAKENHI-PROJECT-23590324
[Presentation] Networks of transcription and metabolism: physiology, diseases, and structural basis.（オーガナイザー）2012
- Author(s)
  五十嵐和彦
- Organizer
  第85回日本生化学会大会シンポジウム
- Place of Presentation
  福岡国際会議場
- Year and Date
  2012-12-15
- Data Source
  KAKENHI-ORGANIZER-23116001
[Presentation] SAMIT核内モジュールによるSAM合成とヒストンメチル化の共役2011
- Author(s)
  五十嵐和彦
- Organizer
  日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PLANNED-23116003
[Presentation] 鉄代謝と転写制御のクロストークとその出力異常2011
- Author(s)
  五十嵐和彦
- Organizer
  第12回WAKOつくばフォーラム
- Place of Presentation
  筑波和光ホール(茨城県つくば市)
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-21249014
[Presentation] 鉄代謝と転写制御のクロストークとその出力異常2011
- Author(s)
  五十嵐和彦
- Organizer
  第12回WAKOつくばフォーラム
- Place of Presentation
  筑波和光ホール
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-21249014
[Presentation] Coupling of metabolism and transcription by a denosylmethionine transferase2011
- Author(s)
  Kazuhiko Igarashi
- Organizer
  Invited Seminar, Jawaharlal Nehru Center for Advanced Scientific Research, India
- Place of Presentation
  Bangalore、インド
- Year and Date
  2011-12-23
- Data Source
  KAKENHI-PLANNED-23116003
[Presentation] Coupling of metabolism and transcription by adenosylmethionine transferase2011
- Author(s)
  Kazuhiko Igarashi
- Organizer
  Invited Seminar, Institute of Chemical Biology, India
- Place of Presentation
  Kolkata、インド
- Year and Date
  2011-12-22
- Data Source
  KAKENHI-PLANNED-23116003
[Presentation] Sertonin metabolites act on the nuclear receptor PPARg as endogenous ligands independently of fatty-acid metabolites2011
- Author(s)
  Shiraki, T., Morikawa, K., Igarashi, K.
- Organizer
  LXXVI Cold Spring Harbor Symposium on Quantitative Biology
- Place of Presentation
  Cold Spring Harbor Laboratory, NY, USA
- Data Source
  KAKENHI-PROJECT-23590324
[Presentation] MafK-dependent and -independent nuclear function of methionine adenosyltransferase2011
- Author(s)
  Kazuhiko Igarashi
- Organizer
  日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PLANNED-23116003
[Presentation] 核内メチル化反応を支えるタンパク質ネットワーク2010
- Author(s)
  五十嵐和彦
- Organizer
  日本薬学会シンポジウム
- Place of Presentation
  岡山コンベンションセンター
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-17054028
[Presentation] Regulation of erythroid and lympohoid differentiation by heme-binding transcription factors Bach1 and Bach22010
- Author(s)
  K.Igarashi
- Organizer
  日本血液学会シンポジウム
- Place of Presentation
  横浜市
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-21249014
[Presentation] Regulation of erythroid and lympohoid differentiation by heme-binding transcription factors Bach1 and Bach2.2010
- Author(s)
  K.Igarashi
- Organizer
  日本血液学会シンポジウム
- Place of Presentation
  横浜市
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-16088101
[Presentation] Cross-talk between Bach1, NF-kB, and IL-6 in epithelial-mesenchymal transition2009
- Author(s)
  Brydun, A., Nakanome A., Matsumoto, M., Ota, K., Dohi, Y., Igarashi, K
- Organizer
  American Association for Cancer Reserch International Conference on Frontiers in Basic Cancer Research
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-17054028
[Presentation] Dense co-regulators network for HO-1 gene expression 6th International Congress on Hemeoxygenases2009
- Author(s)
  五十嵐和彦
- Organizer
  Heme oxygenases in Biology & Medicine
- Place of Presentation
  マイアミビーチリゾートアンドスパ(米国)
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-17054028
[Presentation] Dense co-regulators network for HO-1 gene expression 6th International Congress on Heme oxygenases2009
- Author(s)
  五十嵐和彦
- Organizer
  Heme oxygenases in Biology & Medicine
- Place of Presentation
  マイアミビーチリゾートアンドスパ(米国)
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21249014
[Presentation] Dense co-regulators network for HO-1 gene expression 6th International Congress on Heme oxygenases2009
- Author(s)
  五十嵐和彦
- Organizer
  Heme oxygenases in Biology & Medicine
- Place of Presentation
  マイアミビーチリゾートアンドスパ
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21249014
[Presentation] Regulation of erythroid and lympohoid differentiation by heme-binding transcription factors Bach1 and Bach22009
- Author(s)
  K. Igarashi
- Organizer
  日本血液学会シンポジウム
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21249014
[Presentation] Dense co-regulators network for HO-1 gene expression 6th International Congress on Heme oxygenases2009
- Author(s)
  五十嵐和彦
- Organizer
  Heme oxygenases in Biology & Medicine
- Place of Presentation
  マイアミビーチリゾートアンドスパ(米国)
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20659041
[Presentation] Bach1-p53 complex mediates histone deacetylation at p53 target genes and sets threshold for cellular senescence2008
- Author(s)
  Dohi, Y., Ikura, T., Hoshikawa, Y., Noda, T., and Igarashi, K
- Organizer
  Asian Forum of Chromosome and Chromatin Biology and symposium on Nuclear Architecture and Chromatin Dynamics,
- Place of Presentation
  Hderabad, India
- Year and Date
  2008-11-27
- Data Source
  KAKENHI-PROJECT-19390068
[Presentation] Regulation of cell proliferation by the heme-Bach1 pathway2006
- Author(s)
  Kazuhiko Igarashi
- Organizer
  Gordon Research Conference on Tetrapyrroles, Chemistry and Biology of
- Place of Presentation
  Newport, RI, USA
- Data Source
  KAKENHI-PROJECT-17054028
[Presentation] Heme-mediated gene regulation in mammalian cells2005
- Author(s)
  K. Igarashi, Y. Zenke, Y. Dohi
- Organizer
  Cold Spring Harbor Laboratory Meeting "Mechanisms of eukaryotic transcription"
- Place of Presentation
  マイアミ. USA
- Data Source
  KAKENHI-PROJECT-17054028
[Presentation] The heme-Bach1 pathway regulates the adaptive erythropoiesis under iron deficiency.
- Author(s)
  五十嵐和彦
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24390066
[Presentation] Transcriptional Factor Bach2 is regulated by PI3K-mTOR pathway and promotes cell cycle arrest
- Author(s)
  玉原亨、落合恭子、五十嵐和彦
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25670156
[Presentation] Bach2の発現量が活性化B細胞の運命を決定する
- Author(s)
  武藤哲彦、落合恭子、黒崎知博、五十嵐和彦
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25670156
[Presentation] The function of methionine adenosyltransferase 2 in plasma cell differentiation.
- Author(s)
  Kazuhiko Igarashi
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PLANNED-23116003
[Presentation] アクチンファミリータンパク質Arp5およびArp8によるヒトINO80クロマチンリモデリング複合体の機能制御：遺伝子破壊細胞とbicyclic peptidesを用いた解析
- Author(s)
  高橋裕一朗、村上寛和、加藤恭丈、Andrey Brydum、Davide Bertold、Raphael Gubeli、西嶋仁、柴原慶一、五十嵐和彦、Christian Heinis、原田昌彦
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  みなとみらい国際会議場（神奈川県・横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25460351
[Presentation] Bach2 and HDAC3 repress Blimp-1 gene expression in B cells through the histone deacetylation
- Author(s)
  武藤哲彦、田中　拡、落合恭子、加藤恭丈、仁尾正記、五十嵐和彦
- Organizer
  Cold Spring Harbor Asia Conference: Frontiers of Immunology in Health and Diseases
- Place of Presentation
  The Suzhou Dushu Lake Conference Center （中国・蘇州）
- Year and Date
  2014-09-02 – 2014-09-06
- Data Source
  KAKENHI-PROJECT-25670156
[Presentation] The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program.
- Author(s)
  A Ito-Nakadai, A Muto, M Watanabe-Matsui, K Kometani, Y Sato, T Ikawa, K Ochiai, T Kurosaki, K Igarashi
- Organizer
  2015 Keystone Symposia Conference : The Golden Anniversary of B Cell Discovery
- Place of Presentation
  Fairmont Banff Springs （カナダ、バンフ）
- Year and Date
  2015-03-22 – 2015-03-27
- Data Source
  KAKENHI-PLANNED-23116003
[Presentation] 大規模解析にむけた血漿プロテオーム
- Author(s)
  蝦名真行、加藤恭丈、五十嵐和彦、田邉修
- Organizer
  第12回日本ヒトプロテオーム学会（JHUPO）
- Place of Presentation
  つくば国際会議場（茨城県・つくば市）
- Year and Date
  2014-07-17 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-25460351
[Presentation] Roles of Bach2 in the function and development of alveolar macrophages and　pulmonary homeostasis.
- Author(s)
  SHIBUYA Risa, IGARASHI Kazuhiko
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24390066
[Presentation] Roles of Bach2 in the development of alveolar macrophage.
- Author(s)
  R. Shibuya, K. Igarashi
- Organizer
  Keystone Symposia meeting on Dendritic Cells and Macrophages Reunitd
- Place of Presentation
  Fairmont The Queen Elizabeth （カナダ、モントリオール）
- Year and Date
  2015-03-08 – 2015-03-13
- Data Source
  KAKENHI-PROJECT-24390066
[Presentation] The heme-bach1 axis orchestrates the adaptive gene responeses during iron-deficient anemia.
- Author(s)
  Kazuhiko Igarashi
- Organizer
  筑波大学グローバル教育院World Science Leaders' Seminar
- Place of Presentation
  筑波大学（茨城県つくば市）
- Invited
- Data Source
  KAKENHI-PROJECT-24390066
[Presentation] Nuclear localization of the catalytic subunit of methionine adenosyltransferase II is promoted by its regulatory subunit.
- Author(s)
  Katoh Y, Igarashi K.
- Organizer
  IIAS Research Conference 2014 Chromatin Decoding
- Place of Presentation
  公益財団法人国際高等研究所（京都府・京都市）
- Year and Date
  2014-05-12 – 2014-05-15
- Data Source
  KAKENHI-PROJECT-25460351
[Presentation] The transcription repressor Bach2 collaborates with EBF1 to promote B cell development by curbing myeloid program.
- Author(s)
  Ari Itoh-Nakadai, Yuki Sato, Kazuhiko Igarashi
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24390066
[Presentation] 形質細胞分化の誘導・維持に関わる転写因子とクロマチン制御因子の定量的質量分析による同定
- Author(s)
  島弘季、高柳香、黒河内祐子、五十嵐和彦
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25670156
[Presentation] Local synthesis of S-adenosylmethionine for local consumption: how metabolism is coupled with epigenomic regulation.
- Author(s)
  Kazuhiko Igarashi
- Organizer
  5th Meeting of the Asian Forum of Chromosome and Chromatin Biology
- Place of Presentation
  Jawaharlal Nehru Center for Advanced Scientific Research （インド、バンガロール）
- Year and Date
  2015-01-15 – 2015-01-18
- Invited
- Data Source
  KAKENHI-PLANNED-23116003
[Presentation] 転写因子によるB細胞-形質細胞分化調節ネットワーク
- Author(s)
  五十嵐和彦、落合恭子、加藤恭丈、武藤哲彦
- Organizer
  国際高等研究所クロマチンデコーディング集会
- Place of Presentation
  国際高等研究所
- Invited
- Data Source
  KAKENHI-PLANNED-23116003
[Presentation] Contribution of nuclear localized MATIIα to nuclear SAM pool.
- Author(s)
  Masayuki Ebina, Yasutake Katoh, Kazuhiko Igarashi
- Organizer
  5th Meeting of the Asian Forum of Chromosome and Chromatin Biology
- Place of Presentation
  Jawaharlal Nehru Center for Advanced Scientific Research （インド、バンガロール）
- Year and Date
  2015-01-15 – 2015-01-18
- Data Source
  KAKENHI-PLANNED-23116003
[Presentation] ヘムーBach1経路による遺伝子発現調節と鉄欠乏への適応
- Author(s)
  五十嵐和彦
- Organizer
  第38回日本鉄バイオサイエンス学会学術集会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2014-09-06 – 2014-09-07
- Invited
- Data Source
  KAKENHI-PROJECT-24390066
[Presentation] ヘムによる天然変性タンパク質Bach2の制御 Heme regulates intrinsically disorder protein Bach2
- Author(s)
  Miki Watanabe-Matsui, Kazutaka Murayama, Toshitaka Matsui, Masao Ikeda-Saito, Kazuhiko Igarashi
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24390066
[Presentation] 大規模コホートにおける血漿プロテオーム解析サンプルの標準化
- Author(s)
  加藤恭丈、蝦名真行、城田松之、木下賢吾、五十嵐和彦、山本雅之、田邉修
- Organizer
  第12回日本ヒトプロテオーム学会（JHUPO）
- Place of Presentation
  つくば国際会議場（茨城県・つくば市）
- Year and Date
  2014-07-17 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-25460351
[Presentation] ヘムによる遺伝子発現の制御と免疫への関与
- Author(s)
  五十嵐和彦
- Organizer
  第10回Future of Atherosclerosis,Hypertension and Diabetes Mellitus(FATDM)
- Place of Presentation
  山の上ホテル別館（東京都千代田区）
- Invited
- Data Source
  KAKENHI-PROJECT-24390066
[Presentation] 大規模住民コホート研究のためのLC-MS/MSによる血漿プロテオーム解析の標準化
- Author(s)
  加藤恭丈, 蝦名真行, 城田松之, 木下賢吾, 五十嵐和彦, 田邉修, 山本雅之
- Organizer
  第87回日本生化学会年会
- Place of Presentation
  京都国際会議場（京都府・京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25460351
[Presentation] Local synthesis of S-adenosylmethionine for local consumption: how metabolism is coupled with epigenomic regulation.
- Author(s)
  Kazuhiko Igarashi
- Organizer
  5th Meeting of the Asian Forum of Chromosome and Chromatin Biology
- Place of Presentation
  Jawaharlal Nehru Center for Advanced Scientific Research （インド、バンガロール）
- Year and Date
  2015-01-15 – 2015-01-18
- Invited
- Data Source
  KAKENHI-PROJECT-24390066

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53. エンゲルダグラス

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56. IKAWA Tomokatsu

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57. SUN Jying

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58. HANDA Osamu

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60. ISE Masako

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61. ICHINOHASAMA Ryo

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# of Collaborated Products: 3 results
72. 石井直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
73. 一ノ瀬正和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
74. 中山啓子

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
75. 舟山亮

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
76. 渋谷里紗

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
77. 桑原誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
78. 齋藤正男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
79. 松井敏高

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
80. 伊藤友子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
81. 内藤裕二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
82. 高木智久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
83. 堅田和弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
84. 落合恭子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
85. 奥山隆平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
86. 前田達哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
87. 山本照子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
88. 尾間由佳子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
89. 荒瀬尚

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
90. 北村大志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
91. 鈴木穣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
92. 石澤賢一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
93. 福原規子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
94. 正井久雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
95. 須賀田直子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
96. 藤原亨

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
97. 田中耕三

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
98. 池田真教

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
99. 難波文彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
100. 小林信吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
101. 伊藤光宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
102. 小川誠司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
103. 辻田忠志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
104. ALAM MD. MORSHEDUL

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
105. 志賀清人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
106. 加藤光保

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
107. 沖田結花里

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
108. 鈴木裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
109. 小関健由

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# of Collaborated Products: 1 results
110. 伊藤悦朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
111. 斉藤寿仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
112. 胡桃坂仁志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
113. 斉藤隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
114. 青木淳賢

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
115. 伊藤亜里

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Igarashi Kazuhiko 五十嵐 和彦

IGARASHI Kazuhiko 五十嵐 和彦

Research Projects

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Co-Researchers

がん細胞のBACH1依存性を活用した新規治療戦略の開発Principal InvestigatorOngoing

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Age-related alterations of hematopoietic stem and progenitor cells due to failure of Bach transcription factorsPrincipal InvestigatorOngoing

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Elucidation of epigenetic regulation of erythropoiesis and translation to therapeutic strategyPrincipal InvestigatorOngoing

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新規治療の開発を目指したBach1の筋損傷抑制効果の解明Ongoing

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Development of a new strategy for tumor immunity activationPrincipal Investigator

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Regulation of erythropoiesis and macrophages by the heme signalPrincipal Investigator

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Novel molecular mechanism collaborating stem neural stem cell mainteinance and differentiation

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Profiling of proteins associated with cell differentiation based on changes in relative abundance and post-translational modification.Principal Investigator

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Methods rewriting epigenome as the target of methyonine adenosyltransferase II

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Regulation of immune cells by heme and its receptors Bach1 and Bach2Principal Investigator

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Coupring mechanism of methionine metabolism and epigenomePrincipal Investigator

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Regulation of nuclear receptor activity by intracellular signals and ligands

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Elucidation of the transcription factor network that regulates cancer-stroma interactionPrincipal Investigator

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Igarashi Kazuhiko 五十嵐和彦

IGARASHI Kazuhiko 五十嵐和彦