MARUYAMA Yoshio 丸山芳夫

Researcher Number	00133942
Affiliation (based on the past Project Information) *help	2014: 東北大学, 大学院医学系研究科, 教授 2011 – 2013: 東北大学, 医学(系)研究科(研究院), 教授 2007 – 2009: Tohoku University, 大学院・医学系研究科, 教授 2007: 東北大学, 大学院・医学系・研究科, 教授 2006: 東北大学, 大学院医学系研究科, 教授 … More 2002 – 2005: 東北大学, 医学系研究科, 教授 2000 – 2001: 東北大学, 医学部, 教授 1999 – 2001: School of Medicine, Tohoku University, 大学院・医学系研究科, 教授 1996 – 1998: 東北大学, 医学部, 教授 1988 – 1995: 自治医科大学, 医学部, 助教授 1987: University of Tokyo, Faculty of Medicine, 医学部(医), 助手 1986: Faculty of Medicine, University of Tokyo (Instructor), 医学部, 助手 1986: 東大, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator General physiology / Biological Sciences / General physiology Except Principal Investigator General physiology / Biological Sciences / General physiology / 医学一般
Keywords	Principal Investigator 膵腺腺房細胞 / 膜容量 / パッチクランプ法 / イオンチャネル / 出芽 / カルシウム / オルガネラ膜 / Kチャネル / イベリオトキシン / Ca応答 … More / 小胞体 / 膜容量計測法 / 開口放出 / 核膜小胞体 / 肝細胞 / 膵腺房細胞 / 核膜 / イノシトール3リン酸 / 膜容量変化 / アラキドン酸 / membrane capacitance / pancreatic acinar cells / 細胞内カルシウム / 粗面小胞体 / Membrane capacitance / Endoplasmic reticulum / Budding / 細胞内Ca / チャネル / 膜電位依存性 / オイルスキン法 / 核 / K_+チャネル / Cl-チャネル / オイルスキン / フシファーイエロー / 核小胞体膜 / パッチークランプ法 / 小胞体管腔カルシウム / 出芽機構 / Maxi-Kチャネル / パッチ-クランプ法 / 小胞体膜 / パッチクランプ浩 / 核膜・小胞体膜 / 膜可塑性 / 膵外分泌腺 / 核膜空間 / レーザー顕微鏡 / 核膜イオンチャネル / 核膜の可塑性 / 低分子量GTP結合蛋白 / GDP解離抑制因子 / GDP解離促進因子 / VIP / furaー2 / サイクリックAMP / イノシト-ル三リン酸 / ルテニウムレッド / 巨核球 / カルシウム濃度 / G蛋白 / 膵外分泌腺細胞 / シグナル伝達 / Small molecular GTP-binding protein / GDP-dissociation inhibitor / GDP-dissociation stimulator / chromaffin cells / カルシウムイオン / カルシウム動員受容体 / イノシトール三リン酸 / イノシトール四リン酸 / GTP結合蛋白 / Calcium / Surface charge / Inositol polyphasphate / arachidonate / exocytosis / Pancreatic acinar cell / 分泌顆粒 / エクソサイト-ジス / プライミング / 炭素電極 / Cellular calcium / Secretory granule / パッチクランプ / 小胞体カルシウム / カリウムチャネル / 発芽 / Patch-clamp / Ion channel / Lumenal calcium / 小胞形成 / カルシウム信号 / Ca_<2+>濃度 / Ca_<2+>シグナル / 粗面小胞体膜 / maxi-Kチャネル / Clチャネル / アセチルコリン受容体 / カルシウムシグナル / 小胞体Ca / endoplasmic reticulum / patch-clamp / calcium / vesicle formation / ion channels / calcium signaling / 膜コンダクタンス変化 / GTP-結合蛋白 / 外分泌腺腺房細胞 / 細胞内メッセンジャー / パッチ・クランプ法 / Pancreatic acxinar cells / Cell membrane capacitance / Cell membrane conductance / GTP-binding protein … More Except Principal Investigator イオンチャネル / 腎臓 / CD38ノックアウトマウス / capacitative Ca2+entry / submandibular acinar cell / acetylcholine / cyclic ADP-ribose / ryanodine / xestospongin C / IP3 / サイクリックADPリボース / アセチルコリン / 膵腺腺房細胞 / カルシウムオシレーション / リアノジン感受性プール / カルシウムシグナリング / ムスカリン受容体 / 小細胞肺がん / 肺動脈 / 換気血流不均等 / 低酸素 / ヘムオキシゲナーゼ / 小胞体 / 上皮輸送 / 分泌と吸収 / 細胞内調節 / シグナル変換 / CaーIP_3、DGーCキナ-ゼ / ACーcAMP / pH調節 / 膜容量の変化 / CaーIP_3,DGーCキナ-ゼ系 / ACーcAMP系 / 容積調節 / 細胞内カルシウム動員 / プロテインキナ-ゼC / サイクリックAMP / epithelial transport / secretion and absorption / intracellular regulation / signal transduction / Ca-IP_3, DG-C Kinase / AC-cAMP / pH regulation / volume regulation / 内向き整流性カリウムチャネル / 水チャネル / 上皮細胞 / ホメオスターシス / グリア / 内向き整流カリウムチャネル / グリア細胞 / Inwardly rectifying K+ channels / Water channels / Epithelial cells / homeostasis / Kidney / Glial cells / 【H^+】 / ペプチド共輸送 / 共輸送連結比 / ペプチド輸送電位 / 特異性 / 細胞内pH microclimate pH / 刷子縁膜 / 小腸 / Proton-peptide cotransport / transport stoichiometry / specificity / peptide-transport potential / microclimate pH / intracellular pH / brush border membrane / intestine / 細胞電気活動 / 細胞形態解析 / 心房筋細胞 / 血管平滑細胞 / 気管支平滑筋細胞 / 腸管平滑筋細胞 / 膵腺房細胞 / 細胞内Ca動態 / 細胞機能解析 / 血管平滑筋細胞 / 腸評滑筋細胞 / 細胞Ca動態 / 細胞内カルシウム測定装置 / パッチクランプ法 / 単一組織細胞 / 興奮ー機能連関 / 興奮一機能連関 / Cellular electrical activities / cellular function analysis / atrial myocyte / bronchial smooth muscle cell / intestinal smooth muscle cell / pancreatic acinar cell / intracellular Ca dynamics / vascular smooth muscle cell Less

Analysis of unconventional orientation of MaxiK channels in the peri-nuclear ER membrane
- Principal Investigator
  
  MURATA Yoshimichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Tohoku University
Ion channel coupling and membrane plasticity in nucleus and mitochondriaPrincipal Investigator
- Principal Investigator
  
  MARUYAMA Yoshio
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Tohoku University
核周辺シグナル伝達基盤としての核孔透過性と内側核膜イオンチャネルPrincipal Investigator
- Principal Investigator
  
  丸山芳夫
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
肺がんの進展に関与する肺循環血流の制御機構の解明
- Principal Investigator
  
  柴原茂樹
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
膜小胞の形成制御と細胞情報伝達連関Principal Investigator
- Principal Investigator
  
  丸山芳夫
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
CD38欠損マウス外分泌腺細胞でのアゴニスト誘起性カルシウム応答の解析
- Principal Investigator
  
  福士靖江
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Tohoku University
The physiological roles and molecular basis of polarized localization of K+ channels in the vectorial transports of ions and water.
- Principal Investigator
  
  KURACHI Yoshihisa
- Project Period (FY)
  2000 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
細胞ファイバー系のin vivoアッセイPrincipal Investigator
- Principal Investigator
  
  丸山芳夫
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Tohoku University
小胞体膜イオンチャネルのオルガネラパッチクランプ法による展開Principal Investigator
- Principal Investigator
  
  丸山芳夫
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
Dynamics of vesicle formation controlled by cellular messenger signalingPrincipal Investigator
- Principal Investigator
  
  MARUYAMA Yoshio
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  TOHOKU UNIVERSITY
粗面小胞体膜の動的構造と発芽機構(膜の構造化原理について)Principal Investigator
- Principal Investigator
  
  丸山芳夫
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Tohoku University
Features of granule motion and of vesicular fusion by local cell signalingPrincipal Investigator
- Principal Investigator
  
  MARUYAMA Yoshio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Jichi Medical School
Dynamics of vesicular tronsformation in maclear complex.Principal Investigator
- Principal Investigator
  
  MARUYAMA Yoshio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Jichi Medical School
Control of granular fusion by small molecular GTP-binding proteinPrincipal Investigator
- Principal Investigator
  
  MARUYAMA Yoshio
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Jichi Medical School
Control of Secretion and Absorption in Epithelial Cells : Cellular Mechanism
- Principal Investigator
  
  NISHIYAMA Akinori
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  General physiology
- Research Institution
  Tohoku University
Physiological roles of low molecular weight 20KG GTP-binding protein : Effects on secretion in pancreatic acinar cells.Principal Investigator
- Principal Investigator
  
  MARUYAMA Yoshio
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Jichi Medical School
System for the simultaneous analysis of the electrical activities and morphophysiological function in a single cell.
- Principal Investigator
  
  SUGIMOTO Tsuneaki
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B).
- Research Field
  
  医学一般
- Research Institution
  University of Tokyo
The electrical transfer properties of basolateral-, luminal-, and gap junctional cell membrane in exocrine gland acinar cells.Principal Investigator
- Principal Investigator
  
  MARUYAMA Yoshio
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  University of Tokyo, Fculty of Medicine
Characterization and energetic analysis of <H^+> -dependent active transport in cells of visceral organs
- Principal Investigator
  
  HOSHI Takeshi
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  University of Tokyo

All 2013 2012 2008 2007

All Journal Article Presentation

[Journal Article] Flagellin/TLR5 signaling potentiates airway serous secretion from swine tracheal submucosal glands2013
- Author(s)
  Soshi Muramatsu, Tsutomu Tamada, Masayuki Nara, Koji Murakami, Toshiaki Kikuchi, Masahiko Kanehira, Yoshio Maruyama, Masahito Ebina, Toshihiro Nukiwa and Masakazu Ichinose
- Journal Title
  
  Am.J. Physiol
  
  Volume: 305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590254
[Journal Article] Amphipaths Differentially Modulate Membrane Surface Deformation in Rat Peritoneal Mast Cells during Exocytosis2013
- Author(s)
  Kazama I, Maruyama Y, Takahashi S, Kokumai T
- Journal Title
  
  Cell Physiol Biochem
  
  Volume: 31(4-5) Pages: 592-600
- DOI
  10.1159/000350079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590254, KAKENHI-PROJECT-25860155
[Journal Article] Benidipine Persistently Inhibits Delayed Rectifier K+-Channel Currents in Murine Thymocytes2013
- Author(s)
  Kazama I, Maruyama Y, Matsubara M
- Journal Title
  
  Immunopharmacol and Immunotoxicol
  
  Volume: 35(1) Pages: 28-33
- DOI
  10.3109/08923973.2012.723011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590254, KAKENHI-PROJECT-23790241, KAKENHI-PROJECT-25860155
[Journal Article] Differential Effects of Clarithromycin and Azithromycin on Delayed Rectifier K+-Channel Currents in Murine Thymocytes2013
- Author(s)
  Kazama I, Maruyama Y
- Journal Title
  
  Pharm Biol
  
  Volume: 51(6) Pages: 760-5
- DOI
  10.3109/13880209.2013.764539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590254, KAKENHI-PROJECT-23790241, KAKENHI-PROJECT-25860155
[Journal Article] Flagellin/TLR5 signaling potentiates airway serous secretion from swine trachal submucosal glands2013
- Author(s)
  Soshi Muramatsu, Tsutomu Tamada, Maayuki Nara, Toshiaki Kikuchi, Masahiko Kanehira, Yoshio Maruyama, Maahito Ebina, Toshihiko Nukiwa, Masakazu Ichinose
- Journal Title
  
  American journal of Physiology Lung Cell mol Physiol
  
  Volume: 305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590254
[Journal Article] Decreased expression of a novel prostaglandin transporter, OAT-PG, facilitates renocortical PGE2 accumulation during rat pregnancy2013
- Author(s)
  Kazama I, Matsubara M, Kanai Y, Hatano R, Asano S, Endo Y, Toyama H, Ejima Y, Kurosawa S, Maruyama Y
- Journal Title
  
  Gynecologic and Obsteric Investigation
  
  Volume: 76 Pages: 163-170
- DOI
  10.1159/000353977
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590254, KAKENHI-PROJECT-24390217, KAKENHI-PROJECT-24590104, KAKENHI-PROJECT-25860693
[Journal Article] Inner mitochondorial Maxi-K channels in neonatal renal tubular cells: Novel therapeutic targets to control apoptosis2012
- Author(s)
  Itsuro Kazama and Yoshio Maruyama
- Journal Title
  
  Medical Hypotheses
  
  Volume: 78 Pages: 8000-8001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590254
[Journal Article] Aspirin-Induced Microscopic Surface Changes Stimulate Thrombopoiesis in Rat Megakaryocytes2012
- Author(s)
  Kazama I, Maruyama Y, Nakamichi S
- Journal Title
  
  Clin Appl Thromb Hemost
  
  Volume: -
- DOI
  10.1177/1076029612461845
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590254, KAKENHI-PROJECT-23790241
[Journal Article] Suppressive Effects of NSAIDs on Kv1.32012
- Author(s)
  Kazama I, Maruyama Y, Murata Y
- Journal Title
  
  Immunopharmacol Immunotoxicol.
  
  Volume: 34(5) Pages: 874-8
- DOI
  10.3109/08923973.2012.666249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590254, KAKENHI-PROJECT-23790241, KAKENHI-PROJECT-24590267
[Journal Article] Voltage-dependent biphasic effects of chloroquine on delayed rectifier K-currents in murine thymocytes2012
- Author(s)
  風間逸郎、丸山芳夫、村田喜理
- Journal Title
  
  J Physiol Sci.
  
  Volume: (印刷中) Pages: 267-274
- DOI
  10.1007/s12576-012-0195-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790198, KAKENHI-PROJECT-23590254, KAKENHI-PROJECT-23790241, KAKENHI-PROJECT-24590267
[Journal Article] Inner Mitochondrial Maxi-K+ Channels in Neonatal Renal Tubular Cells: Novel Therapeutic Targets to Control Apoptosis2012
- Author(s)
  Kazama I, Maruyama Y
- Journal Title
  
  Medical Hypothesis
  
  Volume: 78(6) Pages: 800-1
- DOI
  10.1016/j.mehy.2012.03.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590254, KAKENHI-PROJECT-23790241
[Presentation] K^+-Rb^+共イオン条件下での非対称性Rb^+電流コンダクタンス2008
- Author(s)
  丸山芳夫
- Organizer
  東北生理談話会
- Place of Presentation
  弘前大学医学部
- Year and Date
  2008-10-08
- Data Source
  KAKENHI-PROJECT-20056003
[Presentation] 核・小胞体膜での膜電流と膜容量変化について2007
- Author(s)
  丸山芳夫
- Organizer
  第40回東北生理談話会
- Place of Presentation
  東北大学医学部
- Year and Date
  2007-10-19
- Data Source
  KAKENHI-PROJECT-18059002

1. MURATA Yoshimichi (60455780)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
2. HOSHI Takeshi (60004537)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. KURACHI Yoshihisa (30142011)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 福士靖江 (20125644)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. KAZAMA Itsurou (60593978)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
6. NISHIYAMA Akinori (90004556)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SAITO Yoshitaka (80004670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OKADA Yasunobu (10025661)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SUZUKI Yuichi (50091707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ISHII Masaru (10324758)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. HIBINO Hiroshi (70314317)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MATSUNAGA Hiroshi (50165841)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKUWA Noriko (70150290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SUGIMOTO Tsuneaki (60019883)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NAKAJIMA Toshiaki (50227790)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. IINO Masamitsu (50133939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TANAKA Hiroshi (60155158)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. TOYOOKA Teruhiko (00146151)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 加藤一郎 (50250741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 柴原茂樹 (70206142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 古山和道 (80280874)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 大佐賀敦 (00396433)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 高井義美 (60093514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 田代真人 (90111343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 種本雅之 (40303945)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 稲野辺厚 (00270851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 金井好克

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 浅野真司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 波多野亮

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MARUYAMA Yoshio 丸山 芳夫

Research Projects

Research Products

Co-Researchers

Analysis of unconventional orientation of MaxiK channels in the peri-nuclear ER membrane

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Ion channel coupling and membrane plasticity in nucleus and mitochondriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

核周辺シグナル伝達基盤としての核孔透過性と内側核膜イオンチャネルPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

肺がんの進展に関与する肺循環血流の制御機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

膜小胞の形成制御と細胞情報伝達連関Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

CD38欠損マウス外分泌腺細胞でのアゴニスト誘起性カルシウム応答の解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The physiological roles and molecular basis of polarized localization of K+ channels in the vectorial transports of ions and water.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞ファイバー系のin vivoアッセイPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

小胞体膜イオンチャネルのオルガネラパッチクランプ法による展開Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Dynamics of vesicle formation controlled by cellular messenger signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

粗面小胞体膜の動的構造と発芽機構(膜の構造化原理について)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Features of granule motion and of vesicular fusion by local cell signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Dynamics of vesicular tronsformation in maclear complex.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

MARUYAMA Yoshio 丸山芳夫