MARUYAMA Yoshio 丸山芳夫

Researcher Number	00133942
Affiliation (based on the past Project Information) *help	2014: 東北大学, 大学院医学系研究科, 教授 2011 – 2013: 東北大学, 医学(系)研究科(研究院), 教授 2007 – 2009: Tohoku University, 大学院・医学系研究科, 教授 2007: 東北大学, 大学院・医学系・研究科, 教授 2006: 東北大学, 大学院医学系研究科, 教授 … More 2002 – 2005: 東北大学, 医学系研究科, 教授 2000 – 2001: 東北大学, 医学部, 教授 1999 – 2001: School of Medicine, Tohoku University, 大学院・医学系研究科, 教授 1996 – 1998: 東北大学, 医学部, 教授 1988 – 1995: 自治医科大学, 医学部, 助教授 1987: University of Tokyo, Faculty of Medicine, 医学部(医), 助手 1986: Faculty of Medicine, University of Tokyo (Instructor), 医学部, 助手 1986: 東大, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator General physiology / Biological Sciences / General physiology Except Principal Investigator General physiology / Biological Sciences / 医学一般 / General physiology
Keywords	Principal Investigator 膵腺腺房細胞 / 膜容量 / イオンチャネル / パッチクランプ法 / カルシウム / 出芽 / 小胞体 / Ca応答 / イベリオトキシン / Kチャネル … More / オルガネラ膜 / Budding / Endoplasmic reticulum / Membrane capacitance / 粗面小胞体 / 細胞内カルシウム / pancreatic acinar cells / membrane capacitance / アラキドン酸 / 膜容量変化 / イノシトール3リン酸 / 核膜 / 膵腺房細胞 / 肝細胞 / 核膜小胞体 / 開口放出 / 膜容量計測法 / GTP-binding protein / Cell membrane conductance / Cell membrane capacitance / Pancreatic acxinar cells / パッチ・クランプ法 / 細胞内メッセンジャー / 外分泌腺腺房細胞 / GTP-結合蛋白 / 膜コンダクタンス変化 / calcium signaling / ion channels / vesicle formation / calcium / patch-clamp / endoplasmic reticulum / 小胞体Ca / カルシウムシグナル / アセチルコリン受容体 / Clチャネル / maxi-Kチャネル / 粗面小胞体膜 / Ca_<2+>シグナル / Ca_<2+>濃度 / カルシウム信号 / 小胞形成 / Lumenal calcium / Ion channel / Patch-clamp / 発芽 / カリウムチャネル / 小胞体カルシウム / パッチクランプ / Secretory granule / Cellular calcium / 炭素電極 / プライミング / エクソサイト-ジス / 分泌顆粒 / Pancreatic acinar cell / exocytosis / arachidonate / Inositol polyphasphate / Surface charge / Calcium / GTP結合蛋白 / イノシトール四リン酸 / イノシトール三リン酸 / カルシウム動員受容体 / カルシウムイオン / chromaffin cells / GDP-dissociation stimulator / GDP-dissociation inhibitor / Small molecular GTP-binding protein / シグナル伝達 / 膵外分泌腺細胞 / G蛋白 / カルシウム濃度 / 巨核球 / ルテニウムレッド / イノシト-ル三リン酸 / サイクリックAMP / furaー2 / VIP / GDP解離促進因子 / GDP解離抑制因子 / 低分子量GTP結合蛋白 / 核膜の可塑性 / 核膜イオンチャネル / レーザー顕微鏡 / 核膜空間 / 膵外分泌腺 / 膜可塑性 / 核膜・小胞体膜 / パッチクランプ浩 / 小胞体膜 / パッチ-クランプ法 / Maxi-Kチャネル / 出芽機構 / 小胞体管腔カルシウム / パッチークランプ法 / 核小胞体膜 / フシファーイエロー / オイルスキン / Cl-チャネル / K_+チャネル / 核 / オイルスキン法 / 膜電位依存性 / チャネル / 細胞内Ca … More Except Principal Investigator 腎臓 / イオンチャネル / vascular smooth muscle cell / intracellular Ca dynamics / pancreatic acinar cell / intestinal smooth muscle cell / bronchial smooth muscle cell / atrial myocyte / cellular function analysis / Cellular electrical activities / 興奮一機能連関 / 興奮ー機能連関 / 単一組織細胞 / パッチクランプ法 / 細胞内カルシウム測定装置 / 細胞Ca動態 / 腸評滑筋細胞 / 血管平滑筋細胞 / 細胞機能解析 / 細胞内Ca動態 / 膵腺房細胞 / 腸管平滑筋細胞 / 気管支平滑筋細胞 / 血管平滑細胞 / 心房筋細胞 / 細胞形態解析 / 細胞電気活動 / intestine / brush border membrane / intracellular pH / microclimate pH / peptide-transport potential / specificity / transport stoichiometry / Proton-peptide cotransport / 小腸 / 刷子縁膜 / 細胞内pH microclimate pH / 特異性 / ペプチド輸送電位 / 共輸送連結比 / ペプチド共輸送 / 【H^+】 / Glial cells / Kidney / homeostasis / Epithelial cells / Water channels / Inwardly rectifying K+ channels / グリア細胞 / 内向き整流カリウムチャネル / グリア / ホメオスターシス / 上皮細胞 / 水チャネル / 内向き整流性カリウムチャネル / volume regulation / pH regulation / AC-cAMP / Ca-IP_3, DG-C Kinase / signal transduction / intracellular regulation / secretion and absorption / epithelial transport / サイクリックAMP / プロテインキナ-ゼC / 細胞内カルシウム動員 / 容積調節 / ACーcAMP系 / CaーIP_3,DGーCキナ-ゼ系 / 膜容量の変化 / pH調節 / ACーcAMP / CaーIP_3、DGーCキナ-ゼ / シグナル変換 / 細胞内調節 / 分泌と吸収 / 上皮輸送 / 小胞体 / ヘムオキシゲナーゼ / 低酸素 / 換気血流不均等 / 肺動脈 / 小細胞肺がん / ムスカリン受容体 / カルシウムシグナリング / リアノジン感受性プール / カルシウムオシレーション / 膵腺腺房細胞 / アセチルコリン / サイクリックADPリボース / IP3 / xestospongin C / ryanodine / cyclic ADP-ribose / acetylcholine / submandibular acinar cell / capacitative Ca2+entry / CD38ノックアウトマウス Less

Analysis of unconventional orientation of MaxiK channels in the peri-nuclear ER membrane
- Principal Investigator
  
  MURATA Yoshimichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Tohoku University
Ion channel coupling and membrane plasticity in nucleus and mitochondriaPrincipal Investigator
- Principal Investigator
  
  MARUYAMA Yoshio
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Tohoku University
核周辺シグナル伝達基盤としての核孔透過性と内側核膜イオンチャネルPrincipal Investigator
- Principal Investigator
  
  丸山芳夫
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
肺がんの進展に関与する肺循環血流の制御機構の解明
- Principal Investigator
  
  柴原茂樹
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
膜小胞の形成制御と細胞情報伝達連関Principal Investigator
- Principal Investigator
  
  丸山芳夫
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
CD38欠損マウス外分泌腺細胞でのアゴニスト誘起性カルシウム応答の解析
- Principal Investigator
  
  福士靖江
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Tohoku University
The physiological roles and molecular basis of polarized localization of K+ channels in the vectorial transports of ions and water.
- Principal Investigator
  
  KURACHI Yoshihisa
- Project Period (FY)
  2000 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
細胞ファイバー系のin vivoアッセイPrincipal Investigator
- Principal Investigator
  
  丸山芳夫
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Tohoku University
小胞体膜イオンチャネルのオルガネラパッチクランプ法による展開Principal Investigator
- Principal Investigator
  
  丸山芳夫
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
Dynamics of vesicle formation controlled by cellular messenger signalingPrincipal Investigator
- Principal Investigator
  
  MARUYAMA Yoshio
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  TOHOKU UNIVERSITY
粗面小胞体膜の動的構造と発芽機構(膜の構造化原理について)Principal Investigator
- Principal Investigator
  
  丸山芳夫
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Tohoku University
Features of granule motion and of vesicular fusion by local cell signalingPrincipal Investigator
- Principal Investigator
  
  MARUYAMA Yoshio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Jichi Medical School
Dynamics of vesicular tronsformation in maclear complex.Principal Investigator
- Principal Investigator
  
  MARUYAMA Yoshio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Jichi Medical School
Control of granular fusion by small molecular GTP-binding proteinPrincipal Investigator
- Principal Investigator
  
  MARUYAMA Yoshio
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Jichi Medical School
Control of Secretion and Absorption in Epithelial Cells : Cellular Mechanism
- Principal Investigator
  
  NISHIYAMA Akinori
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  General physiology
- Research Institution
  Tohoku University
Physiological roles of low molecular weight 20KG GTP-binding protein : Effects on secretion in pancreatic acinar cells.Principal Investigator
- Principal Investigator
  
  MARUYAMA Yoshio
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Jichi Medical School
System for the simultaneous analysis of the electrical activities and morphophysiological function in a single cell.
- Principal Investigator
  
  SUGIMOTO Tsuneaki
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B).
- Research Field
  
  医学一般
- Research Institution
  University of Tokyo
The electrical transfer properties of basolateral-, luminal-, and gap junctional cell membrane in exocrine gland acinar cells.Principal Investigator
- Principal Investigator
  
  MARUYAMA Yoshio
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  University of Tokyo, Fculty of Medicine
Characterization and energetic analysis of <H^+> -dependent active transport in cells of visceral organs
- Principal Investigator
  
  HOSHI Takeshi
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  University of Tokyo

All 2013 2012 2008 2007

All Journal Article Presentation

[Journal Article] Flagellin/TLR5 signaling potentiates airway serous secretion from swine tracheal submucosal glands2013
- Author(s)
  Soshi Muramatsu, Tsutomu Tamada, Masayuki Nara, Koji Murakami, Toshiaki Kikuchi, Masahiko Kanehira, Yoshio Maruyama, Masahito Ebina, Toshihiro Nukiwa and Masakazu Ichinose
- Journal Title
  
  Am.J. Physiol
  
  Volume: 305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590254
[Journal Article] Amphipaths differentially modulate membrane surface deformation in rat peritoneal mast cells during exocytosis2013
- Author(s)
  Kazama I, Maruyama Y, Takahashi S, Kokumai T
- Journal Title
  
  Cell Physiol Biochem
  
  Volume: 31(4-5) Issue: 4-5 Pages: 592-600
- DOI
  10.1159/000350079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590254, KAKENHI-PROJECT-25860155
[Journal Article] Differential effects of clarithromycin and azithromycin on delayed rectifier K(+)-channel currents in murine thymocytes2013
- Author(s)
  Kazama I, Maruyama Y
- Journal Title
  
  Pharm Biol
  
  Volume: 51(6) Issue: 6 Pages: 760-5
- DOI
  10.3109/13880209.2013.764539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590254, KAKENHI-PROJECT-23790241, KAKENHI-PROJECT-25860155
[Journal Article] Flagellin/TLR5 signaling potentiates airway serous secretion from swine trachal submucosal glands2013
- Author(s)
  Soshi Muramatsu, Tsutomu Tamada, Maayuki Nara, Toshiaki Kikuchi, Masahiko Kanehira, Yoshio Maruyama, Maahito Ebina, Toshihiko Nukiwa, Masakazu Ichinose
- Journal Title
  
  American journal of Physiology Lung Cell mol Physiol
  
  Volume: 305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590254
[Journal Article] Decreased Expression of a Novel Prostaglandin Transporter, OAT-PG, Facilitates Renocortical PGE(2) Accumulation during Rat Pregnancy2013
- Author(s)
  Kazama I, Matsubara M, Kanai Y, Hatano R, Asano S, Endo Y, Toyama H, Ejima Y, Kurosawa S, Maruyama Y
- Journal Title
  
  Gynecol Obstet Invest
  
  Volume: 76 Issue: 3 Pages: 163-170
- DOI
  10.1159/000353977
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590254, KAKENHI-PROJECT-24390217, KAKENHI-PROJECT-24590104, KAKENHI-PROJECT-25860693
[Journal Article] Inner mitochondorial Maxi-K channels in neonatal renal tubular cells: Novel therapeutic targets to control apoptosis2012
- Author(s)
  Itsuro Kazama and Yoshio Maruyama
- Journal Title
  
  Medical Hypotheses
  
  Volume: 78 Pages: 8000-8001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590254
[Journal Article] Aspirin-Induced Microscopic Surface Changes Stimulate Thrombopoiesis in Rat Megakaryocytes2012
- Author(s)
  Kazama I, Maruyama Y, Nakamichi S
- Journal Title
  
  Clin Appl Thromb Hemost
  
  Volume: - Issue: 3 Pages: 318-325
- DOI
  10.1177/1076029612461845
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590254, KAKENHI-PROJECT-23790241
[Journal Article] Benidipine persistently inhibits delayed rectifier K(+)-channel currents in murine thymocytes2012
- Author(s)
  Kazama I, Maruyama Y, Matsubara M
- Journal Title
  
  Immunopharmacol Immunotoxicol
  
  Volume: 35(1) Issue: 1 Pages: 28-33
- DOI
  10.3109/08923973.2012.723011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590254, KAKENHI-PROJECT-23790241, KAKENHI-PROJECT-25860155
[Journal Article] Suppressive effects of nonsteroidal anti-inflammatory drugs diclofenac sodium, salicylate and indomethacin on delayed rectifier K+-channel currents in murine thymocytes2012
- Author(s)
  Kazama I, Maruyama Y, Murata Y
- Journal Title
  
  Immunopharmacol Immunotoxicol
  
  Volume: 34(5) Issue: 5 Pages: 874-8
- DOI
  10.3109/08923973.2012.666249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590254, KAKENHI-PROJECT-23790241, KAKENHI-PROJECT-24590267
[Journal Article] Voltage-dependent biphasic effects of chloroquine on delayed rectifier K^+-channel currents in murine thymocytes2012
- Author(s)
  風間逸郎、丸山芳夫、村田喜理
- Journal Title
  
  Journal of Physiological Science
  
  Volume: (印刷中) Issue: 3 Pages: 267-274
- DOI
  10.1007/s12576-012-0195-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790198, KAKENHI-PROJECT-23590254, KAKENHI-PROJECT-23790241, KAKENHI-PROJECT-24590267
[Journal Article] Inner mitochondrial maxi-K⁺channels in neonatal renal tubular cells : novel therapeutic targets to control apoptosis2012
- Author(s)
  Kazama I, Maruyama Y
- Journal Title
  
  Med Hypotheses
  
  Volume: 78(6) Issue: 6 Pages: 800-1
- DOI
  10.1016/j.mehy.2012.03.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590254, KAKENHI-PROJECT-23790241
[Presentation] K^+-Rb^+共イオン条件下での非対称性Rb^+電流コンダクタンス2008
- Author(s)
  丸山芳夫
- Organizer
  東北生理談話会
- Place of Presentation
  弘前大学医学部
- Year and Date
  2008-10-08
- Data Source
  KAKENHI-PROJECT-20056003
[Presentation] 核・小胞体膜での膜電流と膜容量変化について2007
- Author(s)
  丸山芳夫
- Organizer
  第40回東北生理談話会
- Place of Presentation
  東北大学医学部
- Year and Date
  2007-10-19
- Data Source
  KAKENHI-PROJECT-18059002

1. MURATA Yoshimichi (60455780)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
2. HOSHI Takeshi (60004537)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. KURACHI Yoshihisa (30142011)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 福士靖江 (20125644)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. KAZAMA Itsurou (60593978)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
6. NISHIYAMA Akinori (90004556)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SAITO Yoshitaka (80004670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OKADA Yasunobu (10025661)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SUZUKI Yuichi (50091707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ISHII Masaru (10324758)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. HIBINO Hiroshi (70314317)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MATSUNAGA Hiroshi (50165841)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKUWA Noriko (70150290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SUGIMOTO Tsuneaki (60019883)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NAKAJIMA Toshiaki (50227790)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. IINO Masamitsu (50133939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TANAKA Hiroshi (60155158)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. TOYOOKA Teruhiko (00146151)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 加藤一郎 (50250741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 柴原茂樹 (70206142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 古山和道 (80280874)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 大佐賀敦 (00396433)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 高井義美 (60093514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 田代真人 (90111343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 種本雅之 (40303945)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 稲野辺厚 (00270851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MARUYAMA Yoshio 丸山 芳夫

Research Projects

Research Products

Co-Researchers

Analysis of unconventional orientation of MaxiK channels in the peri-nuclear ER membrane

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Ion channel coupling and membrane plasticity in nucleus and mitochondriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

核周辺シグナル伝達基盤としての核孔透過性と内側核膜イオンチャネルPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

肺がんの進展に関与する肺循環血流の制御機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

膜小胞の形成制御と細胞情報伝達連関Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

CD38欠損マウス外分泌腺細胞でのアゴニスト誘起性カルシウム応答の解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The physiological roles and molecular basis of polarized localization of K+ channels in the vectorial transports of ions and water.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞ファイバー系のin vivoアッセイPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

小胞体膜イオンチャネルのオルガネラパッチクランプ法による展開Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Dynamics of vesicle formation controlled by cellular messenger signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

粗面小胞体膜の動的構造と発芽機構(膜の構造化原理について)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Features of granule motion and of vesicular fusion by local cell signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Dynamics of vesicular tronsformation in maclear complex.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

MARUYAMA Yoshio 丸山芳夫