SHIBUTANI Makoto 渋谷淳

… Alternative Names

Shibutani Makoto 渋谷淳

渋谷淳シブタニマコト

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Researcher Number	20311392
Other IDs
Affiliation (Current)	2023: 東京農工大学, (連合)農学研究科(研究院), 卓越教授
Affiliation (based on the past Project Information) *help	2018 – 2020: 東京農工大学, (連合)農学研究科(研究院), 卓越教授 2015: 東京農工大学, 大学院農学研究院, 教授 2012 – 2015: 東京農工大学, (連合)農学研究科(研究院), 教授 2012: 東京農工大学, 大学院・農学研究院, 教授 2010 – 2011: 東京農工大学, 大学院・農学研究院, 准教授 2003 – 2005: 国立医薬品食品衛生研究所, 病理部, 室長 1999 – 2001: 国立医薬品食品衛生研究所, 病理部, 室長
Review Section/Research Field	Principal Investigator Risk sciences of radiation/Chemicals / Applied veterinary science / Veterinary medical science / Applied veterinary science / Basic Section 42020:Veterinary medical science-related
Keywords	Principal Investigator 発がん / cDNA subtraction / phenobarbital / CpGアイランド / DNAメチル化 / マイクロアレイ / 非遺伝子傷害性発癌物質 / 遺伝子傷害性発癌物質 / 非遺云子傷害性発癌物質 / がん … More / 病理学 / 発がん性評価 / 短期予測 / 巨大核 / 細胞増殖活性 / 細胞周期 / アポトーシス / 発がん性短期予測 / 短期発がんスクリーニング / 発達神経毒性 / ニューロン新生 / 海馬歯状回 / 毒性評価法 / メチル化変動 / プロモーション / 遺伝子発現 / 肝臓 / フェノバルビタール / carcinogenesis / promotion / gene expression / liver / In vivo発達神経毒性試験法 / 化学物質リスク / 海馬神経新生 / DNAメチル化異常 / 簡易スクリーニング法 … More Except Principal Investigator 若手支援 / 国際研究者交流 / 遺伝子改変マウス / 病理形態学 / ゲノムコーホート研究 / 次世代分子解析技術 / アカデミア創薬 / ゲノム・エピゲノム解析支援 / 個別化がん予防 / 国際交流 / ATL発症予防 / 分子疫学コーホート研究 / がん化学予防 / ATL発がん機序 / ATL発症リスク / がん分子標的薬剤 Less

Development of risk assessment method on brain development focusing on aberrant regulation of DNA methylationPrincipal Investigator
- Principal Investigator
  
  Shibutani Makoto
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Tokyo University of Agriculture and Technology
Study for establishing a chemical risk evaluation method on brain development utilizing neurogenesis-related parametersPrincipal Investigator
- Principal Investigator
  
  SHIBUTANI MAKOTO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Veterinary medical science
- Research Institution
  Tokyo University of Agriculture and Technology
Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas
- Principal Investigator
  
  IMAI Kohzoh, 中村祐輔
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  The University of Tokyo
Search for in vivo early prediction markers of carcinogenicity based on the induction mechanism of karyomegalyPrincipal Investigator
- Principal Investigator
  
  SHIBUTANI Makoto
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  Tokyo University of Agriculture and Technology
DNAメチル化を指標としたinvivo短期発癌性指標遺伝子の網羅的検索Principal Investigator
- Principal Investigator
  
  渋谷淳
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  National Institute of Health Sciences
Molecular pro filing of genes specifically up-regulated duringPrincipal Investigator
- Principal Investigator
  
  SHIBUTANI Makoto
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied veterinary science
- Research Institution
  National Institute of Health Sciences

All 2021 2020 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Induction of cellular senescence as a late effect and BDNF-TrkB signaling-mediated ameliorating effect on disruption of hippocampal neurogenesis after developmental exposure to lead acetate in rats2021
- Author(s)
  Yamashita Risako、Takahashi Yasunori、Takashima Kazumi、Okano Hiromu、Ojiro Ryota、Tang Qian、Kikuchi Satomi、Kobayashi Mio、Ogawa Bunichiro、Jin Meilan、Kubota Reiji、Ikarashi Yoshiaki、Yoshida Toshinori、Shibutani Makoto
- Journal Title
  
  Toxicology
  
  Volume: 456 Pages: 152782-152782
- DOI
  10.1016/j.tox.2021.152782
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02341
[Journal Article] Identification of gene targets of developmental neurotoxicity focusing on DNA hypermethylation involved in irreversible disruption of hippocampal neurogenesis in rats2020
- Author(s)
  Kikuchi Satomi、Takahashi Yasunori、Ojiro Ryota、Takashima Kazumi、Okano Hiromu、Tang Qian、Woo Gye‐Hyeong、Yoshida Toshinori、Shibutani Makoto
- Journal Title
  
  Journal of Applied Toxicology
  
  Volume: -
- DOI
  10.1002/jat.4089
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02341
[Journal Article] Maternal exposure to hexachlorophene targets intermediate-stage progenitor cells in the hippocampal neurogenesis involving myelin vacuolation of cholinergic and glutamatergic inputs in mice.2016
- Author(s)
  Kato, M., Abe, H., Itahashi, M., Kikuchihara, Y., Kimura, M., Mizukami, S., Yoshida, T., Shibutani, M.
- Journal Title
  
  J. Appl. Toxicol.
  
  Volume: 36 Pages: 211-222
- DOI
  10.1002/jat.3162
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25292170
[Journal Article] Maternal exposure to 3,3’-iminodipropionitrile targets late-stage differentiation of hippocampal granule cell lineages to affect brain-derived neurotrophic factor signaling and interneuron subpopulations in rat offspring.2015
- Author(s)
  Itahashi, M., Abe, H., Tanaka, T., Mizukami, S., Kikuchihara, Y., Yoshida, T., Shibutani, M.
- Journal Title
  
  J. Appl. Toxicol.
  
  Volume: 35 Pages: 884-894
- DOI
  10.1002/jat.3086
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25292170
[Journal Article] Hippocampal Neurogenesis as a Critical Target of Neurotoxicants Contained in Foods2015
- Author(s)
  Shibutani, M.
- Journal Title
  
  Food Safety
  
  Volume: 3 Issue: 1 Pages: 1-15
- DOI
  10.14252/foodsafetyfscj.2014038
- NAID
  130005064504
- ISSN
  2187-8404
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25292170
[Journal Article] Relationship between brain accumulation of manganese and aberration of hippocampal adult neurogenesis after oral exposure to manganese chloride in mice.2015
- Author(s)
  Kikuchihara, Y., Abe, H., Tanaka, T., Kato, M., Wang, L., Ikarashi, Y., Yoshida, T., Shibutani, M.
- Journal Title
  
  Toxicology
  
  Volume: 331 Pages: 24-34
- DOI
  10.1016/j.tox.2015.02.005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25292170
[Journal Article] Maternal exposure to hexachlorophene targets intermediate-stage progenitor cells of the hippocampal neurogenesis in rat offspring via dysfunction of cholinergic inputs by myelin vacuolation.2015
- Author(s)
  Itahashi, M., Abe, H., Tanaka, T., Mizukami, S., Kimura, M., Yoshida, T., Shibutani, M.
- Journal Title
  
  Toxicology
  
  Volume: 328 Pages: 123-134
- DOI
  10.1016/j.tox.2014.12.009
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25292170
[Journal Article] Developmental hypothyroidism abolishes bilateral differences in sonic hedgehog gene control in the rat hippocampal dentate gyrus.2015
- Author(s)
  Tanaka, T., Wang, L., Kimura, M., Abe, H., Mizukami, S., Yoshida, T., Shibutani, M.
- Journal Title
  
  Toxicological Sciences
  
  Volume: 144 Pages: 128-137
- DOI
  10.1093/toxsci/kfu266
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25292170
[Journal Article] Maternal exposure to hexachlorophene targets intermediate-stage progenitor cells in the hippocampal neurogenesis involving myelin vacuolation of cholinergic and glutamatergic inputs in mice.2015
- Author(s)
  Kato, M., Abe, H., Itahashi, M., Kikuchihara, Y., Kimura, M., Mizukami, S., Yoshida, T., Shibutani. M.
- Journal Title
  
  Journal of Applied Toxicology
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25292170
[Journal Article] N-Methyl-N-nitrosourea during late gestation results in concomitant but reversible progenitor cell reduction and delayed neurogenesis in the hippocampus of rats.2014
- Author(s)
  Itahashi M, Wang L, Shiraki A, Abe H, Tanaka T, Murakami T, Yoshida T, Shibutani M.
- Journal Title
  
  Toxicol. Lett.
  
  Volume: 226 Pages: 285-293
- DOI
  10.1016/j.toxlet.2014.02.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J00674, KAKENHI-PROJECT-25292170
[Journal Article] Maternal single injection of N-methyl-N-nitrosourea to cause microcephaly in offspring induces transient aberration of hippocampal neurogenesis in mice.2014
- Author(s)
  Takimoto, N., Liyun, W., Itahashi, M., Ogawa, T., Segawa, R., Hara, S., Murakami, T., Suzuki, K., Shibutani, M.
- Journal Title
  
  Toxicol. Lett.
  
  Volume: 226 Pages: 20-27
- DOI
  10.1016/j.toxlet.2014.01.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25292170
[Journal Article] Involvement of multiple cell cycle aberrations in early preneoplastic liver cell lesions by tumor promotion with thioacetamide in a two-stage rat hepatocarcinogenesis model.2013
- Author(s)
  Kimura, M., Fujii, Y., Yamamoto, R., Yafune, A., Hayashi, S-M., Suzuki, K., Shibutani, M
- Journal Title
  
  Experimental and Toxicologic Pathology
  
  Volume: (印刷中)
- DOI
  10.1016/j.etp.2013.01.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380163
[Journal Article] Cellular distribution of cell cycle-related molecules in the renal tubules of rats treated with renal carcinogens for 28 days ― Relationship between cell cycle aberration and carcinogenesis.2012
- Author(s)
  Taniai E, Hayashi H, Yafune A, Watanabe M, Akane H, Suzuki K, Mitsumori K, Shibutani M
- Journal Title
  
  Arch. Toxicol
  
  Volume: (印刷中) Pages: 1453-1464
- DOI
  10.1007/s00204-012-0829-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J03954, KAKENHI-PROJECT-22380163
[Journal Article] Disruptive cell cycle regulation involving epigenetic downregulation of Cdkn2a (p16Ink4a)in early-stage liver tumor-promotion facilitating liver cell regeneration in rats.2012
- Author(s)
  Tsuchiya, T., Wang, L., Yafune, A., Kimura, M., Ohishi, T., Suzuki, K., Mitsumori, K., Shibutani, M
- Journal Title
  
  Toxicology
  
  Volume: 299(2-3) Pages: 146-154
- DOI
  10.1016/j.tox.2012.05.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380163
[Journal Article] Aberrant activation of ubiquitin D at G_2 phase and apoptosis by carcinogens that evoke cell proliferation after 28-day administration in rats2012
- Author(s)
  Taniai, E., Yafune, A., Hayashi, H., Itahashi, M., Hara-Kudo, Y., Suzuki, K., Mitsumori, K., Shibutani, M
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 37(6) Pages: 1093-1111
- NAID
  10031126015
- URL
  http://dx.doi.org/10.2131/jts.37.1093.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380163
[Journal Article] Fluctuations in cell proliferation, apoptosis, and cell cycle regulation at the early stage of tumor promotion in rat two-stage carcinogenesis models2012
- Author(s)
  Taniai, E., Yafune, A., Kimura, M., Morita, R., Nakane, F., Suzuki, K., Mitsumori, K., Shibutani, M
- Journal Title
  
  J. Toxicol. Sci
  
  Volume: 37(6) Pages: 1113-1126
- NAID
  10031126016
- URL
  http://dx.doi.org/10.2131/jts.37.1113.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] エタノールの発達期曝露はラットの出生後の可逆的な神経新生障害を誘発し、成熟後におけるシナプス可塑性の低下をもたらす2021
- Author(s)
  高橋康徳、山下理紗子、菊地聡美、岡野拡、高嶋和巳、尾城椋太、吉田敏則、渋谷淳
- Organizer
  第37回日本毒性病理学会
- Data Source
  KAKENHI-PROJECT-18H02341
[Presentation] エタノールの発達期曝露によるラットの出生後の海馬歯状回における可逆的な神経新生障害と、成熟後における遅発影響としての新生顆粒細胞のシナプス可塑性の低下2021
- Author(s)
  高橋康徳、山下理紗子、菊地聡美、岡野拡、高嶋和巳、尾城椋太、唐倩、吉田敏則、渋谷淳
- Organizer
  第3回医薬品毒性機序研究会
- Data Source
  KAKENHI-PROJECT-18H02341
[Presentation] 塩化アルミニウムの発達期曝露によるラット海馬歯状回神経新生への影響2020
- Author(s)
  菊地聡美、岡野拡、高橋康徳、高嶋和巳、山下理紗子、小林美央、吉田敏則、渋谷淳
- Organizer
  第47回日本毒性学会
- Data Source
  KAKENHI-PROJECT-18H02341
[Presentation] 海馬神経新生の傷害性に着目したインビボ神経毒性の評価．日本薬理学会合同シンポジウム：化学物質の神経毒性評価の現状と課題2020
- Author(s)
  渋谷淳
- Organizer
  第47回日本毒性学会
- Data Source
  KAKENHI-PROJECT-18H02341
[Presentation] エタノールの発達期曝露によるラットの海馬歯状回における神経新生への影響2020
- Author(s)
  高橋康徳、山下理紗子、菊地聡美、岡野　拡、高嶋和巳、小林美央、吉田敏則、渋谷淳
- Organizer
  第47回日本毒性学会
- Data Source
  KAKENHI-PROJECT-18H02341
[Presentation] 酢酸鉛の発達期曝露によるラット海馬神経新生に対する影響2020
- Author(s)
  山下理紗子、高橋康徳、菊地聡美、高嶋和巳、小林美央、吉田敏則、渋谷淳
- Organizer
  第47回日本毒性学会
- Data Source
  KAKENHI-PROJECT-18H02341
[Presentation] 発達神経毒性検出と発がん性予測にかかるin vivo簡易評価に関する開発研究2020
- Author(s)
  渋谷淳
- Organizer
  第47回日本毒性学会
- Data Source
  KAKENHI-PROJECT-18H02341
[Presentation] イミノジプロピオニトリル発達期暴露によるマウス海馬歯状回ニューロン新生に対する晩発影響とエピジェネティクス毒性2016
- Author(s)
  田中　猛、長谷川　也須子、渡邉　洋祐、板橋　恵、吉田敏則、渋谷　淳
- Organizer
  第32回日本毒性病理学会学術集会
- Place of Presentation
  ｻﾝﾎﾟｰﾄﾎｰﾙ高松・香川国際会議場展示場
- Year and Date
  2016-01-28
- Data Source
  KAKENHI-PROJECT-25292170
[Presentation] 酢酸鉛の発達期暴露によるマウス海馬歯状回のニューロン新生に対する影響2016
- Author(s)
  長谷川也須子、田中　猛、渡邉洋祐、白木彩子、吉田敏則、渋谷　淳
- Organizer
  第32回日本毒性病理学会学術集会
- Place of Presentation
  ｻﾝﾎﾟｰﾄﾎｰﾙ高松・香川国際会議場展示場
- Year and Date
  2016-01-28
- Data Source
  KAKENHI-PROJECT-25292170
[Presentation] 軸索遠位端傷害物質グリシドールのマウスへの発達期曝露による海馬歯状回におけるニューロン新生への影響2016
- Author(s)
  河嶋将司、村山宗理、長谷川也須子、渡邉洋祐、水上さやか、吉田敏則、渋谷　淳
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  名古屋ｳｲﾝｸあいち・愛知産業労働ｾﾝﾀｰ
- Year and Date
  2016-06-29
- Data Source
  KAKENHI-PROJECT-25292170
[Presentation] イミノジプロピオニトリルのマウスへの発達期暴露による海馬歯状回における離乳時および成熟時ニューロン新生に対する影響2015
- Author(s)
  板橋恵、田中猛、白木彩子、阿部一、木村真之、水上さやか、渡邉洋祐、寒川祐見、吉田智則、渋谷淳
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  石川県立音楽堂・金沢市ｱｰﾄﾎｰﾙ･ﾎﾃﾙ日航金沢
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-25292170
[Presentation] イミノジプロピオニトリル発達期暴露によるマウス海馬歯状回のニューロン新生に対する晩発影響2015
- Author(s)
  長谷川也須子、渡邉洋祐、田中猛、白木彩子、板橋恵、Liyun Wang、阿部一、吉田敏則、渋谷淳
- Organizer
  第158回日本獣医学会学術集会
- Place of Presentation
  北里大学十和田キャンパス
- Year and Date
  2015-09-07
- Data Source
  KAKENHI-PROJECT-25292170
[Presentation] Late effect of developmental exposure to 3,3’-iminodipropionitrile on neurogenesis in the hippocampal dentate gyrus in mice2015
- Author(s)
  Yousuke Watanabe, Yasuko Hasegawa-Baba, Takeshi Tanaka, Ayako Shiraki, Megu Itahashi, Liyun Wang, Hajime Abe, Toshinori Yoshida, Makoto Shibutani
- Organizer
  13th European Congress of Toxicologic Pathology in collaboration with the British Society of Toxicological Pathology
- Place of Presentation
  ギルフォード、イギリス
- Year and Date
  2015-09-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25292170
[Presentation] メチルニトロソ尿素 (MNU)の発達期暴露によるマウス海馬歯状回におけるニューロン新生への影響2015
- Author(s)
  白木彩子、阿部一、田中猛、渡邉洋祐、板橋恵、水上さやか、木村真之、寒川祐見、吉田智則、渋谷淳
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  石川県立音楽堂・金沢市ｱｰﾄﾎｰﾙ･ﾎﾃﾙ日航金沢
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-25292170
[Presentation] イミノジプロピオニトリル発達期暴露によるマウス海馬歯状回の神経発生に及ぼす影響2014
- Author(s)
  Wang Liyun、白木彩子、板橋　恵、阿部　一、村上智亮、鈴木和彦、吉田敏則、渋谷　淳
- Organizer
  第30回日本毒性病理学会学術集会
- Place of Presentation
  徳島県郷土文化会館（徳島県）
- Data Source
  KAKENHI-PROJECT-25292170
[Presentation] イミノジプロピオニトリルのラットへの発達期暴露による海馬歯状回における離乳時ニューロン新生に対する影響2014
- Author(s)
  板橋　恵、Wang Liyun、白木彩子、阿部　一、田中　猛、鈴木和彦、吉田敏則、渋谷　淳
- Organizer
  第30回日本毒性病理学会学術集会
- Place of Presentation
  徳島県郷土文化会館（徳島県）
- Data Source
  KAKENHI-PROJECT-25292170
[Presentation] ラット二段階発がんモデルを用いた発がんプロモーション過程早期における細胞増殖、アポトーシス及び細胞周期関連分子の局在変化2013
- Author(s)
  谷合枝里子、八舟宏典、盛田怜子、板橋恵、鈴木和彦、三森国敏、渋谷淳
- Organizer
  第29回日本毒性病理学会学術集会,第29回日本毒性病理学会学術集会講演要旨集
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] 母動物へのmethylnitrosourea単回腹腔内投与によるマウス児動物海馬歯状回のニューロン新生に対する影響2013
- Author(s)
  滝本憲史、小川峻志、勢川理紗、原慎太郎、Wang Liyun、板橋恵、白木彩子、赤根弘敏、鈴木和彦、渋谷淳
- Organizer
  第40回日本毒性学会学術集会
- Place of Presentation
  幕張メッセ（千葉県）
- Data Source
  KAKENHI-PROJECT-25292170
[Presentation] ラット海馬歯状回でのニューロン新生開始時期である胎齢後期でのメチルニトロソ尿素（MNU）の短期間投与による離乳時ニューロン新生への影響2013
- Author(s)
  板橋恵、赤根弘敏、Wang Liyun、白木彩子、滝本憲史、渋谷淳
- Organizer
  第40回日本毒性学会学術集会
- Place of Presentation
  幕張メッセ（千葉県）
- Data Source
  KAKENHI-PROJECT-25292170
[Presentation] チオアセタミドのラット肝発がん促進時に誘発される細胞周期以上に対する酸化性ストレスの関与2012
- Author(s)
  木村真之、藤井雄太、山本龍一、谷合枝里子、八舟宏典、林新茂、鈴木和彦、三森国敏、渋谷淳
- Organizer
  第39回日本毒性学会学術集会,第39回日本毒性学会学術集会講演要旨集
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] 発がん標的性の異なる発がん物質のラットに対する28日間投与時の各標的臓器でのラット腎発がん物質反応指標の変動2012
- Author(s)
  谷合枝里子、八舟宏典、盛田怜子、赤根弘敏、林仁美、鈴木和彦、三森国敏、渋谷淳
- Organizer
  第28回日本毒性病理学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] シンポジウム「オクラトキシンAのリスク評価最前線」、オクラトキシンAの毒性・発がん性に関する現在までの情報2012
- Author(s)
  渋谷淳
- Organizer
  第70回マイコトキシン学会.第70回マイコトキシン学会要旨集
- Place of Presentation
  東京
- Year and Date
  2012-01-06
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] 発がん標的性の異なる発がん物質のラットに対する28日間投与時の各標的臓器でのラット腎発がん物質反応指標の変動2012
- Author(s)
  谷合枝里子、八舟宏典、盛田怜子、赤根弘敏、林仁美、鈴木和彦、三森国敏、渋谷淳
- Organizer
  第28回日本毒性病理学会学術集会,第28回日本毒性病理学会学術集会講演要旨集
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] 巨大核出現を伴う腎発がん物質の28日間投与時でのラット腎尿細管における細胞周期関連分子の発現挙動2011
- Author(s)
  谷合枝里子、土屋卓磨、黒岩有一、林仁美、鈴木和彦、三森国敏、渋谷淳
- Organizer
  第27回日本毒性病理学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2011-01-28
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] Search for in vivo rapid screening markers of renal carcinogens based on the analysis ofinduction mechanism of karyomegaly2011
- Author(s)
  Eriko Taniai, Hitomi Hayashi, Atsunori Yafune, Liyun Wang, Kazuhiko Suzuki, Kunitoshi Mitsumori, Makoto Shibutani
- Organizer
  9thEuropean Congress of Toxicologic Pathology of the European Society of Toxicologic Pathology
- Place of Presentation
  Uppsala, Sweden
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] Search for rapid detection markers of renal carcinogens based on the karyomegalv-induction mechanism in rats2011
- Author(s)
  Eriko Taniai, Hitomi Hayashi, Atsunori Yafune, Kazuhiko Suzuki, Kunitoshi Mitsumori, Makoto Shibutani
- Organizer
  70th Annual Meeting of the Japanese Cancer Association. Proceedings
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] Search for rapid detection markers of renal carcinogens based on the karyomegaly-induction mechanism in rats2011
- Author(s)
  Eriko Taniai, Hitomi Hayashi, Atsunori Yafune, Kazuhiko Suzuki, Kunitoshi Mitsumori, Makoto Shibutani
- Organizer
  70^<th> Annual Meeting of the Japanese Cancer Association. Proceedings
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] 巨大核出現を伴う腎発がん物質の28日間投与時でのラット腎尿細管における細胞周期関連分子の発現挙動2011
- Author(s)
  谷合枝里子、土屋卓磨、黒岩有一、林仁美、鈴木和彦、三森国敏、渋谷淳
- Organizer
  第27回日本毒性病理学会学術集会,第27回日本毒性病理学会学術集会講演要旨集
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] Search for in vivo rapid screening markers of renal carcinogens based on the analysis of induction mechanism of karyomegaly2011
- Author(s)
  Eriko Taniai, Hitomi Hayashi, Atsunori Yafune, Liyun Wang, Kazuhiko Suzuki, Kunitoshi Mitsumori, Makoto Shibutani
- Organizer
  9^<th> European Congress of Toxicologic Pathology of the European Society of Toxicologic Pathology
- Place of Presentation
  Uppsala, Sweden
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] 腎発がん物質の28日間短期投与時でのラットの腎尿細管領域の細胞増殖性を考慮した細胞周期関連分子の発現解析2011
- Author(s)
  谷合枝里子、中村憲彦、林仁美、嶋本敬介、WangLiyun、大石巧、剣持明、小西良子、鈴木和彦、三森国敏、渋谷淳
- Organizer
  第38回日本トキシコロジー学会学術集会,第38回日本トキシコロジー学会学術集会講演要旨集
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] 腎発がん物質の28日間短期投与時でのラットの腎尿細管領域の細胞増殖性を考慮した細胞周期関連分子の発現解析2011
- Author(s)
  谷合枝里子、中村憲彦、林仁美、嶋本敬介、Wang Liyun、大石巧、剣持明、小西良子、鈴木和彦、三森国敏、渋谷淳
- Organizer
  第38回日本トキシコロジー学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] ラットthioacetamide(TAA)肝発がん促進過程で形成される前がん病変における細胞周期破綻の様式2011
- Author(s)
  土屋卓磨、谷合枝里子、八舟宏典、白木彩子、北条友理、鈴木和彦、三森国敏、渋谷淳
- Organizer
  第152回日本獣医学会学術集会,第152回日本獣医学会学術集会講演要旨集
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] 巨大核出現を伴う腎発がん物質の28日間投与ラットの腎尿細管における細胞周期関連分子の発現変化、文部科学省科学研究費補助金がん研究分野の特性等を踏まえた支援活動2011
- Author(s)
  谷合枝里子、土屋卓磨、黒岩有一、林仁美、鈴木和彦、三森国敏、渋谷淳
- Organizer
  個体レベルでのがん研究支援活動
- Place of Presentation
  大津
- Data Source
  KAKENHI-PROJECT-22380163
[Presentation] 28日間反復投与毒性試験の枠組みでのマンガン投与による海馬歯状回ニューロン新生傷害の検討
- Author(s)
  菊地原陽、加藤瑞穂、阿部一、白木彩子、木村真之、田中猛、板橋恵、村上智亮、吉田敏則、渋谷淳
- Organizer
  第157回日本獣医学会学術集会
- Place of Presentation
  北海道大学高等教育推進機構（北海道札幌市）
- Year and Date
  2014-09-09 – 2014-09-12
- Data Source
  KAKENHI-PROJECT-25292170
[Presentation] 脱髄誘発物質ヘキサクロロフェンのマウスへの発達期暴露による離乳時の海馬ニューロン新生に対する影響
- Author(s)
  加藤瑞穂、阿部一、板橋恵、白木彩子、田中猛、菊地原陽、木村真之、水上さやか、村上智亮、吉田敏則、渋谷淳
- Organizer
  第157回日本獣医学会学術集会
- Place of Presentation
  北海道大学高等教育推進機構（北海道札幌市）
- Year and Date
  2014-09-09 – 2014-09-12
- Data Source
  KAKENHI-PROJECT-25292170
[Presentation] ニューロン新生障害を標的とした脳発達エピジェネティック毒性．シンポジウム17：「発生・発達毒性におけるエピジェネティクス研究の新展開」
- Author(s)
  渋谷淳、Wang Liyun
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸ｺﾝﾍﾞﾝｼｮﾝｾﾝﾀｰ（兵庫県神戸市）
- Year and Date
  2014-07-02 – 2014-07-04
- Invited
- Data Source
  KAKENHI-PROJECT-25292170
[Presentation] 脱髄誘発物質ヘキサクロロフェンの発達期暴露によるラット海馬歯状回における離乳時ニューロン新生に対する影響
- Author(s)
  板橋恵、Wang Liyun、阿部一、田中猛、白木彩子、村上智亮、吉田敏則、渋谷淳
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-25292170

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118. ZEMBUTSU Hitoshi (90372820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
119. SASAKI Yasushi (70322328)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
120. IDOGAWA Masashi (00404749)

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121. MARUYAMA Reo (60607985)

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122. KAI Masahiro (80260777)

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123. YOSHIDA Toshinori (80726456)

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# of Collaborated Products: 19 results
124. SUZUKI Kazuhiko (00366626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
125. UNEYAMA Chikako (30206817)

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126. NISHIKAWA Akiyoshi (30164544)

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127. 井上薫 (50392296)

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128. 曹永晩 (00370940)

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129. 中村祐輔 (70217909)

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130. 佐藤薫 (10311391)

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# of Collaborated Products: 2 results

SHIBUTANI Makoto 渋谷 淳

Shibutani Makoto 渋谷 淳

渋谷 淳 シブタニ マコト

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Development of risk assessment method on brain development focusing on aberrant regulation of DNA methylationPrincipal Investigator

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Study for establishing a chemical risk evaluation method on brain development utilizing neurogenesis-related parametersPrincipal Investigator

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Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas

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Search for in vivo early prediction markers of carcinogenicity based on the induction mechanism of karyomegalyPrincipal Investigator

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DNAメチル化を指標としたinvivo短期発癌性指標遺伝子の網羅的検索Principal Investigator

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Molecular pro filing of genes specifically up-regulated duringPrincipal Investigator

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[Journal Article] Induction of cellular senescence as a late effect and BDNF-TrkB signaling-mediated ameliorating effect on disruption of hippocampal neurogenesis after developmental exposure to lead acetate in rats2021

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[Journal Article] Identification of gene targets of developmental neurotoxicity focusing on DNA hypermethylation involved in irreversible disruption of hippocampal neurogenesis in rats2020

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[Journal Article] Maternal exposure to hexachlorophene targets intermediate-stage progenitor cells in the hippocampal neurogenesis involving myelin vacuolation of cholinergic and glutamatergic inputs in mice.2016

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[Journal Article] Maternal exposure to 3,3’-iminodipropionitrile targets late-stage differentiation of hippocampal granule cell lineages to affect brain-derived neurotrophic factor signaling and interneuron subpopulations in rat offspring.2015

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[Journal Article] Hippocampal Neurogenesis as a Critical Target of Neurotoxicants Contained in Foods2015

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[Journal Article] Relationship between brain accumulation of manganese and aberration of hippocampal adult neurogenesis after oral exposure to manganese chloride in mice.2015

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[Journal Article] Maternal exposure to hexachlorophene targets intermediate-stage progenitor cells of the hippocampal neurogenesis in rat offspring via dysfunction of cholinergic inputs by myelin vacuolation.2015

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[Journal Article] Developmental hypothyroidism abolishes bilateral differences in sonic hedgehog gene control in the rat hippocampal dentate gyrus.2015

SHIBUTANI Makoto 渋谷淳

Shibutani Makoto 渋谷淳

渋谷淳シブタニマコト