Moriwaki Hisataka 森脇久隆

… Alternative Names

MORIWAKI Hisataka 森脇久隆

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Researcher Number	50174470
Other IDs
External Links
Affiliation (Current)	2023: 社会医療法人蘇西厚生会まつなみリサーチパーク, 研究部, 研究員
Affiliation (based on the past Project Information) *help	2015: 岐阜大学, 大学院医学系研究科, 教授 2011 – 2015: 岐阜大学, 医学(系)研究科(研究院), 教授 2013: 岐阜大学, 大学院医学系研究科, 教授 2010 – 2011: 岐阜大学, 医学系研究科, 教授 2007 – 2010: Gifu University, Dpearment of Gastroenterology, Professor … More 2006: 岐阜大学, 医学系研究科, 教授 2006: GIFU UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, PROFESSOR, 大学院医学系研究科, 教授 2005: GIFU UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, PROFESSOR, 大学院・医学系研究科, 教授 2004: GIFU UNIVERSITY, SCHOOL OF MEDICINE, PROFESSOR, 大学院・医学研究科, 教授 1997 – 2003: 岐阜大学, 医学部, 教授 1993 – 1996: 岐阜大学, 医学部, 助教授 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology / Biological Sciences Except Principal Investigator Gastroenterology / Gastroenterology / Medical sociology
Keywords	Principal Investigator レチノイド / 化学予防 / 核内受容体 / 分子標的 / 肝癌 / アポトーシス / CANCER CHEMOPREVENTION / HEPATOCELLULAR CARCINOMA / APOPTOSIS / クローン除去 … More / 非環式レチノイド / DIFFERENTIATION INDUCTION / レチノイドX受容体 / RETINOID / 肝臓癌 / 核内受容体異常 / 肝発癌 / 分化誘導 / 遺伝子変異 / RETINOID X RECEPTOR / CASPASE / インターフェロン / STAT1 / サイトカイン / TGF-β / TNF-α / IFN-γ / 核受容体 / 発癌 / レチノイ / レチノイドレセプター / リン酸化 / 肺発癌予防 / 核内受容体修飾異常 / リン酸化・非リン酸化RXR / 肝発癌予防 / 受容体型チロシンキナーゼ / 大腸癌 / 併用化学発癌予防 / 肝細胞癌 / RXRの遺伝子改変マウス / 発癌抑制 / アルブミン / α-フェト蛋白 / 遺伝子発現 / 肺癌 / RETINOIDS / CHEMICAL STRUCTURE / RETINOIC ACID RECEPTOR / RETINOID X REECEPTOR / CLONAL DELETION / NUCLEAR RECEPTOR / MORECURAL TARGET / INTERFERON / 免疫予防 / インターフェロン受容体 / サイトカイン受容体 / 癌細胞 / 癌治療 / 発癌予防 / Liver cancer / Chemoprevention / Immunoprevention / Interferon / Apoptosis / Retinoid / Interferon receptor / 肝再生不全 / カリクレイン / プロテアーゼ阻害剤 / INF-γ / impaired liver regeneration / cytokine / kallikrein / protease inhibitor … More Except Principal Investigator レチノイド / 肝癌 / 化学予防 / 核内受容体 / RETINOID / HEPATOCELLULAR CARCINOMA / NUCLEAR RECEPTOR / 電子カルテ / クリティカルパス / 急性肝不全 / クローン除去 / アポトーシス / CANCER CHEMOPREVENTION / CLONAL DELETION / APOPTOSIS / 分子標的 / TNF-α / NF-kB / small interference RNA / クリニカルパス / 癌 / 情報システム / 若手支援 / 国際研究者交流 / 遺伝子改変マウス / 病理形態学 / ゲノムコーホート研究 / 次世代分子解析技術 / アカデミア創薬 / ゲノム・エピゲノム解析支援 / 個別化がん予防 / 国際交流 / ATL発症予防 / 分子疫学コーホート研究 / がん化学予防 / ATL発がん機序 / ATL発症リスク / がん分子標的薬剤 / バリアンス分析 / クリティカル・インディケータ / クリティカル・インディケータ / 肥満 / 糖尿病 / 肝発癌抑制 / 非アルコール性脂肪肝炎 / 生活習慣病 / 間接カロリーメータ / 蛋白代謝動態 / 分枝鎖アミノ酸 / 栄養管理 / 間接カロリーメーター / 分岐鎖アミノ酸 / acute hepatic failure / indirect calorimetry / protein metabolism / branched-chain amino acid / nutritional support / 肝線維化 / transforming growth factor-β / 伊東細胞 / コラーゲン / TGF-β / Liver Fibrosis / Retinoid / TGF-beta / Stellate Cell / Collagen / バイオ人工肝 / 細胞外マトリックス / 遺伝子治療 / 転写因子 / BAIOARTIFICIAL LIVER / ACUTE HEPATIC FAILURE / EXTRACELLULAR MATRIX / GENE THERAPY / TRANSCRIPTION FACTOR / ユビキチン化 / インターフェロン / UBIQUITINATION / INTERFERON / テロメラーゼ / CANCER CHEMOPREVEN / TELOMERASE / MOLECULAR MARKETTING / 炎症性腸疾患 / TNFR-KOマウス / プロテオーム解析 / 炎症性腸モデル / Trinitrobenzene suiphonic acid (TNBS) / TNF / NF-κB / 実験的大腸炎モデル / TNFRノックアウトマウス / Inflammatory Bowel Disease / TNFR-KO mouse / Proteome / 膜受容体 / MEMBREN RECEPTOR / MOLECUAR TARGET / B型肝炎ウイルス / siRNA / 抗ウイルス薬 / 感染症 / 創薬 / マウス / RNA工学 / ウイルス複製 / Hepatitis B virus / antiviral drug / RNA technology Less

レチノイド核内受容体RXRα遺伝子改変マウスを用いた肝発癌機序の解析Principal Investigator
- Principal Investigator
  
  森脇久隆
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
Elucidation of new target molecules preventing obesity-related liver carcinogenesis
- Principal Investigator
  
  SHIMIZU MASAHITO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
Development of Quality Improvement Method for the Best Clinical Process Using Next-Generation Electronic Medical Record System
- Principal Investigator
  
  SHIRATORI YOSHIMUNE
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical sociology
- Research Institution
  Nagoya University
  Gifu University
Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas
- Principal Investigator
  
  IMAI Kohzoh, 中村祐輔
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  The University of Tokyo
Combination chemoprevention of hepatocellular carcinoma with acyclic retinoid by targeting RXRαphosphorylationPrincipal Investigator
- Principal Investigator
  
  MORIWAKI Hisataka
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
Development of Analyzing Tool for the Best Clinical Cancer Process Using Next-Generation Electronic Medical Record System
- Principal Investigator
  
  SHIRATORI Yoshimune
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical sociology
- Research Institution
  Gifu University
Strategy for chemoprevention of digestive cancers by targeting abnormalities in receptor tyrosine kinases and nuclear receptorsPrincipal Investigator
- Principal Investigator
  
  MORIWAKI Hisataka
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
Strategy for the chemoprevention of hepatocellular carcinoma by targeting phosphorylated RXRaPrincipal Investigator
- Principal Investigator
  
  MORIWAKI Hisataka
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
The study of anti-hepatitis B virus drugs using RNA technology
- Principal Investigator
  
  KIMURA Kiminori
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
  Gifu University
RECEPTOR DYSFUNCTION AND CANCER CHEMOPREVENTION BY RETINOID AND INTERFERON
- Principal Investigator
  
  SHIRATORI Yoshimune
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
The role of cytokine cascade in impaired liver regeneration and development of candidate pharmaceutical(s) to regulate this mechanismPrincipal Investigator
- Principal Investigator
  
  MORIWAKI Hisataka, 奥野正隆
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
The Role of the Tumor Necrosis Factor Receptor in 2,4,6-Trinitrobenzene Sulphonic Acid (TNBS)-induced Colitis in Mice
- Principal Investigator
  
  KATO Tomohiro
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  GIFU UNIVERSITY
APOPTOSIS BY THE INHIBITION OF TELOMERASE ACTIVITY IN CANCER CELLS
- Principal Investigator
  
  UEMATSU Takahiro
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
核受容体蛋白を標的分子としたがん化学予防の研究Principal Investigator
- Principal Investigator
  
  森脇久隆
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
Retinoid upregulates the sensitivity of cancer cells to a cytokine by inducing the cytokine receptorPrincipal Investigator
- Principal Investigator
  
  MORIWAKI Hisataka
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
MODIFICATION OF GROWTH AND APOPTOSIS BY UBIQUITINATION IN HEPATOMA CELL
- Principal Investigator
  
  SHIRATORI Yoshimune
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  GIFU UNIVERSITY
REGULATION OF HEPATOCARCINOGENESIS BY ACYCLIC RETINOIDPrincipal Investigator
- Principal Investigator
  
  MORIWAKI Hisataka
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  GIFU UNIVERSITY
MECHANISMS OF CLONAL DELETION OF HEPATOCELLULAR CARCINOMA BY ACYCLICRETINOIDPrincipal Investigator
- Principal Investigator
  
  MORIWAKI Hisataka
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Gastroenterology
- Research Institution
  GIFU UNIVERSITY
DEVELOPMENT OF BIOARTIFICIAL LIVER
- Principal Investigator
  
  NAGAKI Masahito
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
MECHANISMS OF REGULATION AND CONTROL OF HEPATOCARCINOGENESIS BY ACYCLIC RETINOIDPrincipal Investigator
- Principal Investigator
  
  MORIWAKI Hisataka
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  GIFU UNIVERSITY
Clinical and experimental studies on protein metabolism in acute hepatic failure-with special relation to effects of branched-chain amino acid infusion
- Principal Investigator
  
  SUGIHARA Jun-ichi
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
Inhibition of Liver Fibrosis by Retinoid Antagonist
- Principal Investigator
  
  OKUNO Masataka
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
GENOMIC MECHANISMS OF REGULATION AND CONTROL OF HEPATOCARCINOGENESIS BY RETINOIDSPrincipal Investigator
- Principal Investigator
  
  MORIWAKI Hisataka
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  GIFU UNIVERSITY

[Book] ガイドライン/ガイダンス慢性肝炎2011
- Author(s)
  森脇久隆
- Total Pages
  88
- Publisher
  医事新報社
- Data Source
  KAKENHI-PROJECT-21590838
[Book] ビタミンの科学と最新応用技術2011
- Author(s)
  森脇久隆
- Total Pages
  221
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-21590838
[Book] 新臨床栄養学2011
- Author(s)
  森脇久隆
- Total Pages
  640
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-21590838
[Book] 臨床検査ガイド2011-20122011
- Author(s)
  森脇久隆
- Total Pages
  1104
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-21590838
[Book] 「第5章病態栄養と栄養療法、7その他の疾患、(木)がん」 : 改訂第2版認定病態栄養専門師のための病態栄養ガイドブック2008
- Author(s)
  森脇久隆
- Publisher
  東京 : メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-19590720
[Book] 改訂第2版認定病態栄養専門師のための病態栄養ガイドブック2008
- Author(s)
  森脇久隆
- Total Pages
  356
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-17015016
[Book] 改訂第2版認定病態栄養専門師のための病態栄養ガイドブック2008
- Author(s)
  森脇久隆
- Total Pages
  356
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-19590720
[Book] 医学書院肝硬変のマネジメント2007
- Author(s)
  清水雅仁, 森脇久隆
- Data Source
  KAKENHI-PROJECT-17015016
[Book] 肝硬変のマネジメント2007
- Author(s)
  清水雅仁, 森脇久隆
- Total Pages
  321
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-19590720
[Book] 非環式レチノイドによる肝発癌の予防 : 西口修平編. 肝硬変のマネジメント2007
- Author(s)
  清水雅仁, 森脇久隆
- Publisher
  東京 : 医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-19590720
[Book] 肝硬変のマネジメント2007
- Author(s)
  清水雅仁, 森脇久隆
- Total Pages
  321
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-17015016
[Book] Chemoprevention of hepatocellular carcinoma with retinoid : Therapy for Viral Hepatitis and Prevention of Hepatocellular Carcinoma.2004
- Author(s)
  Moriwaki H et al.
- Total Pages
  8
- Publisher
  Tokyo, Springer.
- Data Source
  KAKENHI-PROJECT-16590584
[Book] Chemoprevention of hepatocellular carcinoma with retinoid : Therapy for Viral Hepatitis and Prevention of Hepatocellular Carcinoma.2004
- Author(s)
  Moriwaki H
- Total Pages
  8
- Publisher
  Tokyo, Springer.
- Data Source
  KAKENHI-PROJECT-14570457
[Journal Article] Preventive effects of astaxanthin on diethylnitrosamine-induced liver tumorigenesis in C57/BL/KsJ-ob/ob obese mice.2016
- Author(s)
  Ohno T, Shimizu M, Shirakami Y, Miyazaki T, Ideta T, Kochi T, Kubota M, Sakai H, Tanaka T, Moriwaki H.
- Journal Title
  
  Hepatol Res
  
  Volume: 46(3) Pages: 201-209
- DOI
  10.1111/hepr.12550
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19320, KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-25860529, KAKENHI-PROJECT-26860498, KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-16K19335
[Journal Article] Pentoxifylline prevents nonalcoholic steatohepatitis-related liver pre-neoplasms by inhibiting hepatic inflammation and lipogenesis.2016
- Author(s)
  Shirakami Y, Shimizu M, Kubota M, Ohno T, Kochi T, Nakamura N, Sumi T, Tanaka T, Moriwaki H, Seishima M.
- Journal Title
  
  Eur J Cancer Prev.
  
  Volume: 25 Pages: 206-15
- DOI
  10.1097/cej.0000000000000172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-25860529, KAKENHI-PROJECT-26860498, KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-16K19335
[Journal Article] Rapid skeletal muscle wasting predicts worse survival in patients with liver cirrhosis.2016
- Author(s)
  Hanai T, Shiraki M, Ohnishi S, Miyazaki T, Ideta T, Kochi T, Imai K, Suetsugu A, Takai K, Moriwaki H, Shimizu M.
- Journal Title
  
  Hepatol Res.
  
  Volume: 印刷中 Pages: 743-751
- DOI
  10.1111/hepr.12616
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-26460997, KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-16K19335
[Journal Article] Sodium alginate prevents progression of non-alcoholic steatohepatitis and liver carcinogenesis in obese and diabetic mice2016
- Author(s)
  Miyazaki T, Shirakami Y, Kubota M, Ideta T, Kochi T, Sakai H, Tanaka T, Moriwaki H, Shimizu M.
- Journal Title
  
  Oncotarget.
  
  Volume: - Pages: 10448-10458
- DOI
  10.18632/oncotarget.7249
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19320, KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-25860529, KAKENHI-PROJECT-26860498, KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-16K19335
[Journal Article] Metabolome analyses uncovered a novel inhibitory effect of acyclic retinoid on aberrant lipogenesis in a mouse diethylnitrosamine-induced hepatic tumorigenesis model.2016
- Author(s)
  Qin XY, Tatsukawa H, Hitomi K, Shirakami Y, Ishibashi N, Shimizu M, Moriwaki H, Kojima S.
- Journal Title
  
  Cancer Prev Res
  
  Volume: 9 Pages: 205-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460988
[Journal Article] The role of indoleamine 2,3-dioxygenase in diethylnitrosamine-induced liver carcinogenesis.2016
- Author(s)
  Shibata Y, Hara T, Nagano J, Nakamura N, Ohno T, Ninomiya S, Ito H, Tanaka T, Saito K, Seishima M, Shimizu M, Moriwaki H, Tsurumi H
- Journal Title
  
  PLoS One
  
  Volume: 11 Pages: 4-11
- DOI
  10.1371/journal.pone.0146279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H06247, KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-16K09352
[Journal Article] Skeletal muscle depletion is an independent prognostic factor for hepatocellular carcinoma.2015
- Author(s)
  Iritani S, Imai K, Takai K, Hanai T, Ideta T, Miyazaki T, Suetsugu A, Shiraki M, Shimizu M, Moriwaki H.
- Journal Title
  
  J Gastroenterol
  
  Volume: 50 Pages: 323-332
- DOI
  10.1007/s00535-014-0964-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460997, KAKENHI-PROJECT-25460988
[Journal Article] Metformin suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-+Leprdb/+Leprdb mice.2015
- Author(s)
  Shimizu M, Ohno T, Shirakami Y, Baba A, Kochi T, Kubota M, Tsurumi H, Tanaka T, Moriwaki H.
- Journal Title
  
  PLoS One
  
  Volume: 10
- DOI
  10.1371/journal.pone.0124081
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-25860529, KAKENHI-PROJECT-26860498
[Journal Article] Peretinoin after curative therapy of hepatitis C-related hepatocellular carcinoma : a randomized double-blind placebo-controlled study2015
- Author(s)
  Okita K, Izumi N, Matsui O, Tanaka K, Kaneko S, Moriwaki H, Ikeda K, Osaki Y,　Numata K, Nakachi K, Kokudo N, Imanaka K, Nishiguchi S, Okusaka T, Nishigaki Y,　Shiomi S, Kudo M, Ido K, Karino Y, Hayashi N, Ohashi Y, Makuuchi M, Kumada H
- Journal Title
  
  J Gastroenterol
  
  Volume: 50 Pages: 191-202
- DOI
  10.1007/s00535-014-0956-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461805, KAKENHI-PROJECT-221S0001
[Journal Article] Sarcopenia impairs prognosis of patients with liver cirrhosis.2015
- Author(s)
  Hanai T, Shiraki M, Nishimura K, Ohnishi S, Imai K, Suetsugu A, Takai K, Shimizu M, Moriwaki H.
- Journal Title
  
  Nutrition
  
  Volume: 31 Pages: 193-199
- DOI
  10.1016/j.nut.2014.07.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460997, KAKENHI-PROJECT-25460988
[Journal Article] The dipeptidyl peptidase-4 inhibitor teneligliptin attenuates hepatic lipogenesis via AMPK activation in non-alcoholic fatty liver disease model mice.2015
- Author(s)
  Ideta T, Shirakami Y, Miyazaki T, Kochi T, Sakai H, Moriwaki H, Shimizu M.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 16(12) Pages: 29207-18
- DOI
  10.3390/ijms161226156
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19320, KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-26860498
[Journal Article] Preventive effects of captopril, an angiotensin-converting enzyme inhibitor, on the development of azoxymethane-induced colonic preneoplastic lesions in diabetic and hypertensive rats.2014
- Author(s)
  Kochi T, Shimizu M, Ohno T, Baba A, Sumi T, Kubota M, Shirakami Y, Tsurumi H, Tanaka T, Moriwaki H.
- Journal Title
  
  Oncol Lett
  
  Volume: 8 Pages: 223-229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460988
[Journal Article] Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation2014
- Author(s)
  Ohnishi K, Semi K, Yamamoto T, Shimizu M, Tanaka A, Mitsunaga K, Okita K, Osafune K, Arioka Y, Maeda T, Soejima H, Moriwaki H, Yamanaka S, Woltjen K, Yamada Y.
- Journal Title
  
  Cell
  
  Volume: 156 Pages: 663-677
- DOI
  10.1016/j.cell.2014.01.005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23659181, KAKENHI-PROJECT-24390096, KAKENHI-PROJECT-24880023, KAKENHI-PROJECT-25460987, KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-25893084, KAKENHI-PROJECT-26670169, KAKENHI-PROJECT-221S0001
[Journal Article] Free fatty acid as a marker of energy malnutrition in liver cirrhosis.2014
- Author(s)
  Hanai T, Shiraki M, Nishimura K, Imai K, Suetsugu A, Takai K, Shimizu M, Naiki T, Moriwaki H.
- Journal Title
  
  Hepatol Res
  
  Volume: 44 Pages: 218-228
- DOI
  10.1111/hepr.12112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890081, KAKENHI-PROJECT-25460987, KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-26460997
[Journal Article] Survey of survival among patients with hepatitis C virus-related hepatocellular carcinoma treated with peretinoin, an acyclic retinoid, after the completion of a randomized, placebo-controlled trial2014
- Author(s)
  Okita, K., Izumi N., Ikeda K., Osaki Y., Numata K., Ikeda M., Kokudo N., Imanaka K., Nishiguchi S., Kondo S., Nishigaki Y., Shiomi S., Ueshima K., Isoda N., Karino Y., Kudo M., Tanaka K., Kaneko S., Moriwaki H., Makuuchi M., et al.
- Journal Title
  
  J Gastroenterol
- DOI
  10.1007/s00535-014-0996-1
- Description
  Epub ahead of print
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Pharmaceutical and nutraceutical approaches for preventing liver carcinogenesis: Chemoprevention of hepatocellular carcinoma using acyclic retinoid and branched-chain amino acids.2014
- Author(s)
  Shimizu M, Shirakami Y, Hanai T, Imai K, Suetsugu A, Takai K, Shiraki M, Moriwaki H.
- Journal Title
  
  Mol Nutr Food Res
  
  Volume: 58 Pages: 124-135
- DOI
  10.1002/mnfr.201300538
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890081, KAKENHI-PROJECT-25460987, KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-26460997, KAKENHI-PROJECT-26860498, KAKENHI-PROJECT-221S0001
[Journal Article] Non-alcoholic steatohepatitis and preneoplastic lesions develop in the liver of obese and hypertensive rats: suppressing effects of EGCG on the development of liver lesions.2014
- Author(s)
  Kochi T, Shimizu M, Terakura D, Baba A, Ohno T, Kubota M, Shirakami Y, Tsurumi H, Tanaka T, Moriwaki H.
- Journal Title
  
  Cancer Letters
  
  Volume: 342 Pages: 60-69
- DOI
  10.1016/j.canlet.2013.08.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460987, KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-25860529
[Journal Article] Combination of Bevacizumab and Acyclic Retinoid Inhibits the Growth of Hepatocellular Carcinoma Xenografts2014
- Author(s)
  Kubota M, Shimizu M, Baba A, Ohno T, Kochi T, Shirakami Y, Moriwaki H.
- Journal Title
  
  J Nutr Sci Vitaminol
  
  Volume: 60 Issue: 5 Pages: 357-362
- DOI
  10.3177/jnsv.60.357
- NAID
  130004773635
- ISSN
  0301-4800, 1881-7742
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-25860529, KAKENHI-PROJECT-26860498, KAKENHI-PROJECT-221S0001
[Journal Article] Impact of serum chemerin levels on liver functional reserves and platelet counts in patients with hepatocellular carcinoma.2014
- Author(s)
  Imai K, Takai K, Hanai T, Shiraki M, Suzuki Y, Hayashi H, Naiki T, Nishigaki Y, Tomita E, Shimizu M, Moriwaki H.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 15 Pages: 11294-11306
- DOI
  10.3390/ijms150711294
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460988
[Journal Article] A newly synthesized compound, 4'-geranyloxyferulic acid-N(omega)-nitro-l-arginine methyl ester suppresses inflammation-associated colorectal carcinogenesis in male mice.2014
- Author(s)
  Shimizu M, Kochi T, Shirakami Y, Genovese S, Epifano F, Fiorito S, Mori T, Tanaka T, Moriwaki H.
- Journal Title
  
  Int J Cancer
  
  Volume: 135 Pages: 774-784
- DOI
  10.1002/ijc.28718
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-26860498
[Journal Article] A novel aromatic mutagen, 5-amino-6-hydroxy-8H-benzo [6,7] azepino [5,4,3-de] quinolin-7-one (ABAQ), induces colonic preneoplastic lesions in mice.2014
- Author(s)
  Kochi T, Shimizu M, Totsuka Y, Shirakami Y, Nakanishi T, Watanabe T, Tanaka T, Nakagama H, Wakabayashi K, Moriwaki H.
- Journal Title
  
  Toxicology Rep
  
  Volume: 1 Pages: 69-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460988
[Journal Article] Effects of indoleamine 2,3-dioxygenase deficiency on high-fat diet-induced hepatic inflammation.2013
- Author(s)
  Nagano J, Shimizu M, Hara T, Shirakami Y, Kochi T, Nakamura N, Ohtaki H, Ito H, Tanaka T, Tsurumi H, Saito K, Seishima M, Moriwaki H
- Journal Title
  
  PLoS One
  
  Volume: 9;8(9)
- DOI
  10.1371/journal.pone.0073404
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390149, KAKENHI-PROJECT-25460987, KAKENHI-PROJECT-25460988
[Journal Article] Chemical-induced Carcinogenesis.2013
- Author(s)
  Tanaka T, Shimizu M, Moriwaki H.
- Journal Title
  
  J Exp Clin Med
  
  Volume: 5 Pages: 203-209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460987
[Journal Article] Liver acid sphingomyelinase inhibits growth of metastatic colon cancer.2013
- Author(s)
  Osawa Y,Saibara T et.al
- Journal Title
  
  The Journal of clinical investigation
  
  Volume: 123(2) Pages: 834-843
- DOI
  10.1172/jci65188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590979, KAKENHI-PROJECT-23591013, KAKENHI-PROJECT-23790787, KAKENHI-PROJECT-24590981, KAKENHI-PROJECT-24890081, KAKENHI-PROJECT-25460999, KAKENHI-PROJECT-221S0001
[Journal Article] Chemical-induced Carcinogenesis.2013
- Author(s)
  Tanaka T, Shimizu M, Moriwaki H.
- Journal Title
  
  J Exp Clin Med
  
  Volume: 5 Pages: 203-209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460988
[Journal Article] The effect of acyclic retinoid on the metabolomic profiles of hepatocytes and hepatocellular carcinoma cells.2013
- Author(s)
  Xian-Yang Qin, Feifei Wei, Masaru Tanokura, Naoto Ishibashi, Masahito Shimizu, Hisataka Moriwaki, Soichi Kojima
- Journal Title
  
  PloS one
  
  Volume: 8
- DOI
  10.1371/journal.pone.0082860
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12F02090, KAKENHI-PROJECT-13F03217, KAKENHI-PROJECT-23228003, KAKENHI-PUBLICLY-24102533, KAKENHI-PROJECT-25460987, KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-221S0001
[Journal Article] Tumor necrosis factor-α promotes cholestasis-induced liver fibrosis in the mouse through tissue inhibitor of metalloproteinase-1 production in hepatic stellate cells.2013
- Author(s)
  Osawa Y,Saibara T et.al
- Journal Title
  
  PloS one
  
  Volume: 8（6）
- DOI
  10.1371/journal.pone.0065251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590979, KAKENHI-PROJECT-23591013, KAKENHI-PROJECT-24590981, KAKENHI-PROJECT-24890270, KAKENHI-PROJECT-25460999, KAKENHI-PROJECT-221S0001
[Journal Article] Obesity and hepatocellular carcinoma: targeting obesity-related inflammation for chemoprevention of liver carcinogenesis.2013
- Author(s)
  Shimizu M, Tanaka T, Moriwaki H.
- Journal Title
  
  Seminars in immunopathology
  
  Volume: 35 Pages: 191-202
- DOI
  10.1007/s00281-012-0336-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] (－)-Epigallocatechin-3-gallate suppresses hepatic preneoplastic lesions developed in a novel rat model of non-alcoholic steatohepatitis.2013
- Author(s)
  Sumi T, Shirakami Y, Shimizu M, Kochi T, Ohno T, Kubota M, Shiraki M, Tsurumi H, Tanaka T, Moriwaki H.
- Journal Title
  
  SpringerPlus
  
  Volume: 2 Pages: 690-690
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460987
[Journal Article] (－)-Epigallocatechin-3-gallate suppresses hepatic preneoplastic lesions developed in a novel rat model of non-alcoholic steatohepatitis.2013
- Author(s)
  Sumi T, Shirakami Y, Shimizu M, Kochi T, Ohno T, Kubota M, Shiraki M, Tsurumi H, Tanaka T, Moriwaki H.
- Journal Title
  
  SpringerPlus
  
  Volume: 2 Pages: 690-690
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460988
[Journal Article] Synergistic growth inhibition by acyclic retinoid and phosphatidylinositol 3-kinase inhibitor in human hepatoma cells.2013
- Author(s)
  Baba A, Shimizu M, Ohno T, Shirakami Y, Kubota M, Kochi T, Terakura D, Tsurumi H, Moriwaki H.
- Journal Title
  
  BMC Cancer
  
  Volume: 13 Pages: 465-465
- DOI
  10.1186/1471-2407-13-465
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460987, KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-25860529
[Journal Article] Enhanced development of azoxymethane-induced colonic preneoplastic lesions in hypertensive rats2013
- Author(s)
  Takahiro Kochi, Masahito Shimizu, Tomohiko Ohno, Atsushi Baba, Takafumi Sumi, Masaya Kubota, Yohei Shirakami, Hisashi Tsurumi, Takuji Tanaka, and Hisataka Moriwaki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 14 Pages: 14700-14711
- DOI
  10.3390/ijms140714700
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501324, KAKENHI-PROJECT-25460987, KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-25860529
[Journal Article] Hepatocellular carcinoma patients with increased oxidative stress levels are prone to recurrence after curative treatment: a prospective case series study using the d-ROM test.2013
- Author(s)
  Suzuki Y, Imai K, Takai K, Hanai T, Hayashi H, Naiki T, Nishigaki Y, Tomita E, Shimizu M, Moriwaki H.
- Journal Title
  
  J Cancer Res Clin Oncol
  
  Volume: 139 Pages: 845-852
- DOI
  10.1007/s00432-013-1389-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460987, KAKENHI-PROJECT-25460988
[Journal Article] Synergistic growth inhibition of human hepatocellular carcinoma cells by acyclic retinoid and GW4064, a farnesoid X receptor ligand2012
- Author(s)
  Ohno T, Shirakami Y, Shimizu M, Kubota M, Sakai H, Yasuda Y, Kochi T, Tsurumi H, Moriwaki H
- Journal Title
  
  Cancer Lett
  
  Volume: (in press)
- NAID
  110009544360
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Cancer chemoprevention by carotenoids2012
- Author(s)
  Tanaka T, Shimizu M, Moriwaki H
- Journal Title
  
  Molecules
  
  Volume: 14, 17(3) Pages: 3202-3242
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Nutraceutical approach for preventing obesity-related colorectal and liver carcinogenesis2012
- Author(s)
  Shimizu M, Kubota M, Tanaka T, Moriwaki H
- Journal Title
  
  Int J Mol Sci
  
  Volume: 13 Pages: 579-595
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Cancer chemoprevention by carotenoids.2012
- Author(s)
  Tanaka T, Shnimizu M, Moriwaki H.
- Journal Title
  
  Molecules
  
  Volume: 17 Pages: 3202-42
- DOI
  10.3390/molecules17033202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Preventive effects of curcumin on the development of azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db obese mice2012
- Author(s)
  Kubota M, Shimizu M, Sakai H, Yasuda Y, Terakura D, Baba A, Ohno T, Tsurumi H, Tanaka T, Moriwaki H
- Journal Title
  
  Nutr Cancer
  
  Volume: 64 Pages: 72-79
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Monosodium glutamate-induced diabetic mice are susceptible to azoxymethane-induced colon tumorigenesis2012
- Author(s)
  Hata K, Kubota M, Shimizu M, Moriwaki H, Kuno T, Tanaka T, Hara A, Hirose Y
- Journal Title
  
  Carcinogenesis
  
  Volume: 33 Pages: 702-707
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Suppression of azoxymethane-induced colonic preneoplastic lesions in rats by 1-methyltryptophan, an inhibitor of indoleamine 2,3-dioxygenase2012
- Author(s)
  Ogawa K, Hara T, Shimizu M, Ninomiya S, Nagano J, Sakai H, Hoshi M, Ito H, Tsurumi H, Saito K, Seishima M, Tanaka T, Moriwaki H
- Journal Title
  
  Cancer Sci
  
  Volume: 103 Pages: 951-8
- DOI
  10.1111/j.1349-7006.2012.02237.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590838, KAKENHI-PROJECT-24890270
[Journal Article] Combination of acyclic retinoid with branched-chain amino acids inhibits xenograft growth of human hepatoma cells in nude mice2012
- Author(s)
  Shimizu M, Shirakami Y, Sakai H, Iwasa J, Shiraki M, Takai K, Naiki T, Moriwaki H
- Journal Title
  
  Hepatol Res
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Role of acyclic retinoid in the chemoprevention of hepatocellular carcinoma: basic aspects, clinical applications, and future prospects.2012
- Author(s)
  Shimizu M, Imai K, Takai K, Moriwaki H.
- Journal Title
  
  Curr Cancer Drug Targets
  
  Volume: 12 Pages: 1119-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Dual induction of caspase 3-and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells2011
- Author(s)
  Tatsukawa H, Sano T, Fukaya Y, Ishibashi N, Watanabe M, Okuno M, Moriwaki H, Kojima S
- Journal Title
  
  Mol Cancer
  
  Volume: 10 Pages: 4-4
- NAID
  120006341956
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Ultraviolet enhances the sensitivity of pancreatic cancer cells to gemcitabine by activation of 5' AMP-activated protein kinase2011
- Author(s)
  Adachi S, Yasuda I, Kawaguchi J, Yamauchi T, Nakashima M, Itani M, Nakamura M, Yoshioka T, Moriwaki H, Kozawa O
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 414 Pages: 53-59
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Preventive effects of (-)-epigallocatechin gallate on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db Mice2011
- Author(s)
  Shimizu M, Sakai H, Shirakami Y, Yasuda Y, Kubota M, Terakura D, Baba A, Ohno T, Hara Y, Tanaka T, Moriwaki H
- Journal Title
  
  Cancer Prev Res
  
  Volume: 4 Pages: 396-403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression2011
- Author(s)
  Osawa Y, Seki E, Kodama Y, Suetsugu A, Miura K, Adachi M, Ito H, Shiratori Y, Banno Y, Olefsky JM, Nagaki M, Moriwaki H, Brenner DA, Seishima M
- Journal Title
  
  FASEB J
  
  Volume: 25 Pages: 1133-1144
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice2011
- Author(s)
  Shimizu M, Yasuda Y, Sakai H, Kubota M, Terakura D, Baba A, Ohno T, Kochi T, Tsurumi H, Tanaka T, Moriwaki H
- Journal Title
  
  BMC Cancer
  
  Volume: 11 Pages: 281-281
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression.2011
- Author(s)
  Osawa Y, Seki E, Kodama Y, Suetsugu A, Miura K, Adachi M, Ito H, Shiratori Y, Banno Y, Olefsky JM, Nagaki M, Moriwaki H, Brenner DA, Seishima M.
- Journal Title
  
  FASEB J
  
  Volume: 25 Pages: 1133-1144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590591
[Journal Article] L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin2011
- Author(s)
  Osawa Y, Kanamori H, Seki E, Hoshi M, Ohtani H, Yasuda Y, Ito H, Suetsugu A, Nagaki M, Moriwaki H, Saito K, Seishima M
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 34800-34808
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells2011
- Author(s)
  Tatsukawa H, Sano T, Fukaya Y, Ishibashi N, Watanabe M, Okuno M, Moriwaki H, Kojima S
- Journal Title
  
  Mol Cancer
  
  Volume: 10 Pages: 4-4
- NAID
  120006341956
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Phosphorylation status of heat shock protein 27 plays a key role in gemcitabine-induced apoptosis of pancreatic cancer cells2011
- Author(s)
  Nakashima M, Adachi S, Yasuda I, Yamauchi T, Kawaguchi J, Itani M, Yoshioka T, Matsushima-Nishiwaki R, Hirose Y, Kozawa O, Moriwaki H
- Journal Title
  
  Cancer Lett
  
  Volume: 313 Pages: 218-225
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] C57BL/KsJ-db/db-Apc Mice Exhibit an Increased Incidence of Intestinal Neoplasms2011
- Author(s)
  Hata K, Kubota M, Shimizu M, Moriwaki H, Kuno T, Tanaka T, Hara A, Hirose Y
- Journal Title
  
  Int J Mol Sci
  
  Volume: 12(11) Pages: 8133-8145
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Chemoprevention of hepatocellular carcinoma by acyclic retinoid2011
- Author(s)
  Shimizu M, Sakai H, Moriwaki H
- Journal Title
  
  Front Biosci
  
  Volume: 16 Pages: 759-769
- NAID
  110009594131
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Inhibition of Rho-associated coiled-coil containing protein kinase enhances the activation of epidermal growth factor receptor in pancreatic cancer cells2011
- Author(s)
  Nakashima M, Adachi S, Yasuda I, Yamauchi T, Kawaguchi J, Hanamatsu T, Yoshioka T, Okano Y, Hirose Y, Kozawa O, Moriwaki H
- Journal Title
  
  Mol Cancer
  
  Volume: 10 Pages: 79-79
- NAID
  120006341951
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Renin-angiotensin system inhibitors suppress azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice2011
- Author(s)
  Kubota M, Shimizu M, Sakai H, Yasuda Y, Ohno T, Kochi T, Tsurumi H, Tanaka T, Moriwaki H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 410 Pages: 108-113
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Ultraviolet irradiation can induce evasion of colon cancer cells from stimulation of epidermal growth factor2011
- Author(s)
  Adachi S, Yasuda I, Nakashima M, Yamauchi T, Kawaguchi J, Shimizu M, Itani M, Nakamura M, Nishii Y, Yoshioka T, Hirose Y, Okano Y, Moriwaki H, Kozawa O
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 26178-26187
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Rho-kinase inhibitor upregulates migration by altering focal adhesion formation via the Akt pathway in colon cancer cells2011
- Author(s)
  Adachi S, Yasuda I, Nakashima M, Yamauchi T, Yoshioka T, Okano Y, Moriwaki H, Kozawa O
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 650 Pages: 145-150
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Preventive effects of(-)-epigallocatechin gallate on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db Mice2011
- Author(s)
  Shimizu M, Sakai H, Shirakami Y, Yasuda Y, Kubota M, Terakura D, Baba A, Ohno T, Hara Y, Tanaka T, Moriwaki H
- Journal Title
  
  Cancer Prev Res
  
  Volume: 4 Pages: 396-403
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Synergistic growth inhibition in HL-60 cells by the combination of acyclic retinoid and vitamin K22011
- Author(s)
  Kitagawa J, Hara T, Tsurumi H, Ninomiya S, Ogawa K, Adachi S, Kanemura N, Kasahara S, Shimizu M, Moriwaki H
- Journal Title
  
  J Cancer Res Clin Oncol
  
  Volume: 137(5) Pages: 779-787
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Indirect calorimetry and anthropometry to estimate energy metabolism in patients with liver cirrhosis2011
- Author(s)
  Terakura Y, Shiraki M, Nishimura K, Iwasa J, Nagaki M, Moriwaki H
- Journal Title
  
  J Nutr Sci Vitaminol
  
  Volume: 56 Pages: 372-379
- NAID
  10027415275
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Possible role of visfatin in hepatoma progression and the effects of branched-chain amino acids on visfatin-induced proliferation in human hepatoma cells2011
- Author(s)
  Ninomiya S, Shimizu M, Imai K, Takai K, Shiraki M, Hara T, Tsurumi H, Ishizaki S, Moriwaki H
- Journal Title
  
  Cancer Prev Res(Phila)
  
  Volume: 4(12) Pages: 2092-2100
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Increased levels of serum leptin are a risk factor for the recurrence of stage I/II hepatocellular carcinoma after curative treatment2011
- Author(s)
  Watanabe N, Takai K, Imai K, Shimizu M, Naiki T, Nagaki M, Moriwaki H
- Journal Title
  
  J Clin Biochem Nutr
  
  Volume: 49(3) Pages: 153-158
- NAID
  130004466652
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Acyclic retinoid inhibits diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BLKS/J-+(db)/+Lepr(db) mice2011
- Author(s)
  Shimizu M, Sakai H, Shirakami Y, Iwasa J, Yasuda Y, Kubota M, Takai K, Tsurumi H, Tanaka T, Moriwaki H
- Journal Title
  
  Cancer Prev Res
  
  Volume: 4 Pages: 128-136
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Cancer chemoprevention with green tea catechins by targeting receptor tyrosine kinases2011
- Author(s)
  Shimizu M, Adachi S, Masuda M, Kozawa O, Moriwaki H
- Journal Title
  
  Mol Nutr Food Res
  
  Volume: 55 Pages: 832-843
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Elevated serum tumor necrosis factor-alpha and soluble tumor necrosis factor receptors correlate with aberrant energy metabolism in liver cirrhosis2010
- Author(s)
  Shiraki M, Terakura Y, Iwasa J, Shimizu M, Miwa Y, Murakami N, Nagaki M, Moriwaki H
- Journal Title
  
  Nutrition
  
  Volume: 26 Pages: 269-275
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Acyclic retinoid inhibits angiogenesis by suppressing the MAPK pathway.2010
- Author(s)
  Komi Y, Moriwaki H, Kojima S, et al, 他4名
- Journal Title
  
  Lab Invest 90
  
  Pages: 52-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice.2010
- Author(s)
  Osawa Y, Seki E, Adachi M, Suetsugu A, Ito H, Moriwaki H, Seishima M, Nagaki M.
- Journal Title
  
  Hepatology
  
  Volume: 51 Pages: 237-245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Insulin resistance raises the risk for recurrence of stage I hepatocellularcarcinoma after curative radiofrequency ablation in HCV-positive patiens : A prospective, case-series study2010
- Author(s)
  Imai K, Takai K, Nishigaki Y, Shimizu S, Naiki T, Hayashi H, Uematsu T, Sugihara J, Tomita E, Shimizu M, Nagaki M, Moriwaki H
- Journal Title
  
  Hepatol Res
  
  Volume: 40 Pages: 376-382
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Elevated serum tumor necrosis factor-alpha and soluble tumor necrosis factor receptors correlate with aberrant energy metabolism in liver cirrhosis.2010
- Author(s)
  Shiraki M, Terakura Y, Iwasa J, Shimizu M, Miwa Y, Murakami N, Nagaki M, Moriwaki H.
- Journal Title
  
  Nutrition
  
  Volume: 26 Pages: 269-275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice2010
- Author(s)
  Iwasa J, Shimizu M, Shiraki M, Shirakami Y, Sakai H, Terakura Y, Takai K, Tsurumi H, Tanaka T, Moriwaki H
- Journal Title
  
  Cancer Sci
  
  Volume: 101 Pages: 460-467
- NAID
  10026588190
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] The Study Group for the Standardization of Treatment of Viral Hepatitis Including Cirrhosis, Ministry of Health, Labor and Welfare of Japan. Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis B virus infection for the fiscal year 2008 in Japan2010
- Author(s)
  Kumada H, Okanoue T, Onji M, Moriwaki H, Izumi N, Tanaka E, Chayama K, Sakisaka S, Takehara T, Oketani M, Suzuki F, Toyota J, Nomura H, Yoshioka K, Seike M, Yotsuyanagi H, Ueno Y
- Journal Title
  
  Hepatol Res
  
  Volume: 40 Pages: 1-7
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Ability of IDO to attenuate liver injury in alpha-galactosylcerami de-induced hepatitis model.2010
- Author(s)
  Ito H, Hoshi M, Ohtaki H, Taguchi A, Ando K, Ishikawa T, Osawa Y , Hara A, Moriwaki H, Saito K, Seishima M.
- Journal Title
  
  J Immunol
  
  Volume: 185 Pages: 4554-4560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Ability of IDO to attenuate liver injury in alpha-galactosylceramide-induced hepatitis model2010
- Author(s)
  Ito H, Hoshi M, Ohtaki H, Taguchi A, Ando K, Ishikawa T, Osawa Y, Hara A, Moriwaki H, Saito K, Seishima M
- Journal Title
  
  J Immunol
  
  Volume: 185 Pages: 4554-4560
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Accumulation of refractory factors for pegylated interferon plus ribavirin therapy in older female patients with chronic hepatitis C2010
- Author(s)
  Chayama K, Hayes CN, Yoshioka K, Moriwaki H, Okanoue T, Sakisaka S, Takehara T, Oketani M, Toyota J, Izumi N, Hiasa Y, Matsumoto A, Nomura H, Seike M, Ueno Y, Yotsuyanagi H, Kumada H
- Journal Title
  
  Hepatol Res
  
  Volume: 40 Pages: 1155-1167
- NAID
  10028172403
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] The Study Group for the Standardization of Treatment of Viral Hepatitis Including Cirrhosis, Ministry of Health, Labour and Welfare of Japan. Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis C virus infection for the fiscal year 2008 in Japan2010
- Author(s)
  Kumada H, Okanoue T, Onji M, Moriwaki H, Izumi N, Tanaka E, Chayama K, Sakisaka S, Takehara T, Oketani M, Suzuki F, Toyota J, Nomura H, Yoshioka K, Seike M, Yotsuyanagi H, Ueno Y
- Journal Title
  
  Hepatol Res
  
  Volume: 40 Pages: 8-13
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis C virus infection for the fiscal year 2008 in Japan.2010
- Author(s)
  Kumada H, Okanoue T, Onji M, Moriwaki H, Izumi N, Tanaka E, Chayama K, Sakisaka S, Takehara T, Oketani M, Suzuki F, Toyota J, Nomura H, Yoshioka K, Seike M, Yotsuyanagi H, Ueno Y
- Journal Title
  
  Hepatol Res
  
  Volume: 40 Pages: 8-13
- NAID
  10027406173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Acyclic retinoid inhibits angiogenesis by suppressing the MAPK pathway.2010
- Author(s)
  Komi Y, Moriwaki H, Kojima S, (他4名)
- Journal Title
  
  Lab Invest 90
  
  Pages: 52-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice2010
- Author(s)
  Osawa Y, Seki E, Adachi M, Suetsugu A, Ito H, Moriwaki H, Seishima M, Nagaki M
- Journal Title
  
  Hepatology
  
  Volume: 51 Pages: 237-245
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis B virus infection for the fiscal year 2008 in Japan.2010
- Author(s)
  Kumada H, Okanoue T, Onji M, Moriwaki H, Izumi N, Tanaka E, Chayama K, Sakisaka S, Takehara T, Oketani M, Suzuki F, Toyota J, Nomura H, Yoshioka K, Seike M, Yotsuyanagi H, Ueno Y
- Journal Title
  
  Hepatol Res
  
  Volume: 40 Pages: 1-7
- NAID
  10027406161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Acyclic retinoid inhibits angiogenesis by suppressing the MAPK pathway.2010
- Author(s)
  Komi Y, Sogabe Y, Ishibashi N, Sato Y, Moriwaki H, Shimokado K, Kojima S.
- Journal Title
  
  Lab Invet
  
  Volume: 99 Pages: 52-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Hepatic encephalopathy as a complication of liver cirrhosis : an Asian perspective2010
- Author(s)
  Moriwaki H, Shiraki M, Iwasa J, Terakura Y
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 25 Pages: 858-863
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Hepatic encephalopathy as a complication of liver cirrhosis : an Asian perspective.2010
- Author(s)
  Moriwaki H, Shiraki M, Iwasa J, Terakura Y.
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 25 Pages: 858-863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Insulin resistance raises the risk for recurrence of stage I hepato cellularcarcinoma after curative radiofrequency ablation in HCV-positive patiens : A prospective, case-series study.2010
- Author(s)
  Imai K, Takai K, Nishigaki Y, Shimizu S, Naiki T, Hayashi H, Uematsu T, Sugihara J, Tomita E, Shimizu M, Nagaki M, Moriwaki H.
- Journal Title
  
  Hepatol Res
  
  Volume: 40 Pages: 376-382
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Acyclic retinoid inhibits angiogenesis by suppressing the MAPK pathway2010
- Author(s)
  Komi Y, Sogabe Y, Ishibashi N, Sato Y, Moriwaki H, Shimokado K, Kojima S
- Journal Title
  
  Lab Invest
  
  Volume: 90 Pages: 52-60
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice.2010
- Author(s)
  Iwasa J, Shimizu M, Shiraki M, Shirakami Y, Sakai H, Terakura Y, Takai K, Tsurumi H, Tanaka T, Moriwaki H.
- Journal Title
  
  Cancer Sci
  
  Volume: 101 Pages: 460-467
- NAID
  10026588190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Acyclic retinoid synergises with valproic acid to inhibit growth in human hepatocellular carcinoma cells.2009
- Author(s)
  Tatebe H, Shimizu M, Moriwaki H, (他4名)
- Journal Title
  
  Cancer Lett 285
  
  Pages: 210-217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Synergistic effects of acyclic retinoid and gemcitabine on growth inhibition in pancreatic cancer cells.2009
- Author(s)
  Nakagawa T, Shimizu M, Moriwaki H, et al, 他4名
- Journal Title
  
  Cancer Lett 273
  
  Pages: 250-256
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Synergistic effects of acyclic retinoid and gemcitabine on growth inhibition in pancreatic cancer cells2009
- Author(s)
  Nakagawa T, Shimizu M, Shirakami Y, Tatebe H, Yasuda I, Tsurumi H, Moriwaki H
- Journal Title
  
  Cancer Lett
  
  Volume: 273 Pages: 250-256
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Synergistic effects of acyclic retinoid and gemcitabine on growth inhibition in pancreatic cancer cells.2009
- Author(s)
  Nakagawa T, Shimizu M, Moriwaki H, (他4名)
- Journal Title
  
  Cancer Lett 273
  
  Pages: 250-256
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Synergistic effects of acyclic retinoid and gemcitabine on growth inhibition in pancreatic cancer cells.2009
- Author(s)
  Nakagawa T, Shimizu M, Moriwaki H, et al, (他4名)
- Journal Title
  
  Cancer Lett 273
  
  Pages: 250-256
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Acyclic retinoid synergises with valproic acid to inhibit growth in human hepatocellular carcinoma cells2009
- Author(s)
  Tatebe H, Shimizu M, Shirakami Y, Sakai H, Yasuda Y, Tsurumi H, Moriwaki H
- Journal Title
  
  Cancer Lett
  
  Volume: 285 Pages: 210-217
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Acyclic retinoid synergises with valproic acid to inhibit growth in human hepatocellular carcinoma cells.2009
- Author(s)
  Tatebe H, Shimizu M, Moriwaki H, et al, (他4名)
- Journal Title
  
  Cancer Lett 285
  
  Pages: 210-217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Strategy and mechanism for the prevention of hepatocellular carcinoma : phosphorylated retinoid X receptor alpha is a critical target for hepatocellular carcinoma chemoprevention.2009
- Author(s)
  Shimizu M, Moriwaki H, et al, (他1名)
- Journal Title
  
  Cancer Sci 100
  
  Pages: 369-374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Strategy and mechanism for the prevention of hepatocellular carcinoma : phosphorylated retinoid X receptor alpha is a critical target for hepatocellular carcinoma chemoprevention2009
- Author(s)
  Shimizu M, Takai K, Moriwaki H
- Journal Title
  
  Cancer Sci
  
  Volume: 100 Pages: 369-374
- Data Source
  KAKENHI-PROJECT-21590838
[Journal Article] Acyclic retinoid synergises with valproic acid to inhibit growth in human hepatocellular carcinoma cells.2009
- Author(s)
  Tatebe H, Shimizu M, Moriwaki H, et al, 他4名
- Journal Title
  
  Cancer Lett 285
  
  Pages: 210-217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Synergistic growth inhibition by 9-cis-retinoic acid plus trastuzumab in human hepatocellular carcinoma cells2008
- Author(s)
  Tatebe H, Shimizu M, Shirakami Y, Tsurumi H, Moriwaki H.
- Journal Title
  
  Clin Cancer Res. 14
  
  Pages: 2806-2812
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590720
[Journal Article] Synergistic effects of PPARgamma ligands and retinoids in cancer treatment2008
- Author(s)
  Shimizu M, Moriwaki H
- Journal Title
  
  PPAR Res 2008
  
  Pages: 181047-181047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Synergistic growth inhibition by 9-cis-retinoic acid plus trastuzumab in human hepatocellular carcinoma cells.2008
- Author(s)
  Tatebe H, Shimizu M, Moriwaki H, (他2名)
- Journal Title
  
  Clin Cancer Res 14
  
  Pages: 2806-2812
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Retinoid X receptor alpha is highly phosphorylated in retinoic acidresistant HL-60R cells and the combination of 9-cis retinoic acid plus MEK inhibitor induces apoptosis in the cells.2008
- Author(s)
  Kanemura N, Shimizu M, Moriwaki H, (他3名)
- Journal Title
  
  Leuk Res 32
  
  Pages: 884-892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Synergistic effects of PPARgamma ligands and retinoids in cancer treatment.2008
- Author(s)
  Shimizu M, Moriwaki H
- Journal Title
  
  PPAR Res 2008
  
  Pages: 181047-181047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Critical role of CD44 in Hepatotoxin-mediated liver injury2008
- Author(s)
  Kimura K, Nagaki M, Kakimi K, Saio M, Saeki T, Okuda Y, Kuwata K, Moriwaki H.
- Journal Title
  
  J hepatol
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] EGCG inhibits activation of the insulin-like growth factor (IGF) /IGF-1 receptor axis in human hepatocellular carcinoma cells.2008
- Author(s)
  Shimizu M, Moriwaki H, (他6名)
- Journal Title
  
  Cancer Lett 262
  
  Pages: 10-18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] (-)-Epigallocatechin gallate suppresses azoxymethane-induced colonic premalignant lesions in male C57BL/ KsJ-db/db mice.2008
- Author(s)
  Shimizu M, Moriwaki H, (他6名)
- Journal Title
  
  Cancer Prev Res 1
  
  Pages: 298-304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Green tea extracts for the prevention of metachronous colorectal adenomas: a pilot study.2008
- Author(s)
  Shimizu M, Moriwaki H, (他7名)
- Journal Title
  
  Cancer Epidemiol Biomarkers Prev 17
  
  Pages: 3020-3025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Retinoid X receptor alpha is highly phosphorylated in retinoic acid-resistant HL-60R cells and the combination of 9-cis retinoic acid plus MEK inhibitor induces apoptosis in the cells2008
- Author(s)
  Kanemura N, Tsurumi H, Okuno M, Matsushima-Nishiwaki R, Shimizu M, Moriwaki H.
- Journal Title
  
  Leuk Res. 32
  
  Pages: 884-892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590720
[Journal Article] EGCG inhibits activation of the insulin-like growth factor(IGF)/IGF-1 receptor axis in human hepatocellular carcinoma cells2008
- Author(s)
  Shimizu M, Shirakami Y, Sakai H, Tatebe H, Nakagawa T, Hara Y, Weinstein IB, Moriwaki H.
- Journal Title
  
  Cancer Lett. 262
  
  Pages: 10-18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590720
[Journal Article] Granulocyte colony-stimulating factor impairs liver regeneration in mice through the up-regulation of interleukin-1 beta2007
- Author(s)
  Ogiso T, Nagaki M, Takai S, Tsukada Y, Mukai T, Kimura K, Moriwaki H.
- Journal Title
  
  J Hepatol 47
  
  Pages: 816-825
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590720
[Journal Article] Chemoprevention of liver carcinogenesis with retinoids : Basic and clinic aspects2007
- Author(s)
  Moriwaki H, Shimizu M, Okuno M, Nishiwaki-Matsushima R.
- Journal Title
  
  Hepatol Res. 37(Suppl.2)
- NAID
  10019773579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590720
[Journal Article] Synergistic Growth Inhibition by Acyclic Retinoid and Vitamin K2 in Human Hepatocellular Carcinoma Cells.2007
- Author(s)
  Kanamori T, Shimizu M, Kojima S, Moriwaki H, (他3名)
- Journal Title
  
  Cancer Sci 98
  
  Pages: 431-437
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Phosphorylated retinoid X receptor α loses its heterodimeric activity with retinoic acid receptor β2007
- Author(s)
  Yoshimura K, Muto Y, Shimizu M, Matsushima-Nishiwaki R, Okuno M, Takano Y, Tsurumi H, Kojima S, Okano Y, Moriwaki H.
- Journal Title
  
  Cancer Sci. 98
  
  Pages: 1868-1874
- NAID
  10019996169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590720
[Journal Article] Phosphorylated retinoid X receptor alpha loses its heterodimeric activity with retinoic acid receptor beta.2007
- Author(s)
  Yoshimura K, Shimizu M, Kojima S, Okano Y, Moriwaki H, (他5名)
- Journal Title
  
  Cancer Sci 98
  
  Pages: 1868-1874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Intrinsic resistance to TNF-alpha-induced hepatocyte apoptosis in ICR mice correlates with expression of a short form of c-FLIP2007
- Author(s)
  Takai S, Nagaki M, Imao M, Kimura K, Kozawa O, Moriwaki H.
- Journal Title
  
  Lab Invest 87(6)
  
  Pages: 572-81
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Synergistic effects of RXRα and PPARγ ligands to inhibit growth in human colon cancer cells-phosphorylated RXRα is a critical target for colon cancer management-2007
- Author(s)
  Yamazaki K, Shimizu M, Okuno M, Matsushima-Nishiwaki R, Kanemura N, Araki H, Tsurumi H, Kojima S, Weinstein IB, Moriwaki H.
- Journal Title
  
  Gut 56
  
  Pages: 1557-1563
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590720
[Journal Article] B型肝炎に対する自然免疫の抗ウイルス効果2007
- Author(s)
  木村公則、永木正仁、森脇久隆
- Journal Title
  
  消化器科
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Inhibition of nuclear factor-kappa B induces inflammatory cell migration and exacerbates severe liver injury in hepatitis B virus transgenic mice2007
- Author(s)
  Satake S, Nagaki M, Kimura K, Moriwaki H.
- Journal Title
  
  Hepatol Res 37(7)
  
  Pages: 524-30
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Chemoprevention of liver carcinogenesis with retinoides: Basic and clinical aspects.2007
- Author(s)
  Moriwaki H
- Journal Title
  
  Hepatol Res 37
- NAID
  10019773579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590720
[Journal Article] Synergistic growth inhibition by acyclic retinoid and vitamin K2 in human hepatocellular carcinoma cells2007
- Author(s)
  Kanamori T, Shimizu M, Okuno M, Matsushima-Nishiwaki R, Tsurumi H, Kojima S, Moriwaki H.
- Journal Title
  
  Cancer Sci. 98
  
  Pages: 431-437
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590720
[Journal Article] Synergistic effects of RXR alpha and PPAR gamma ligands to inhibit growth in human colon cancer cells-phosphorylated RXR alpha is a critical target for colon cancer management.2007
- Author(s)
  Yamazaki K, Shimizu M, Kojima S, Moriwaki H, (他6名)
- Journal Title
  
  Gut 56
  
  Pages: 1557-1563
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Chemoprevention of liver carcinogenesis with retinoids: Basic and clinical aspects.2007
- Author(s)
  Moriwaki H, Shimizu M, (他2名)
- Journal Title
  
  Hepatol Res 37
- NAID
  10019773579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Granulocyte colony-stimulating factor impairs liver regeneration in mice through the up-regulation of interleukin-1beta2007
- Author(s)
  Ogiso T, Nagaki M, Takai S, Tsukada Y, Mukai T, Kimura K, Moriwaki H.
- Journal Title
  
  J Hepatol 47(6)
  
  Pages: 816-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Chemoprevention of liver carcinogenesis with retinoids:Basic and clinical aspects2007
- Author(s)
  Moriwaki H
- Journal Title
  
  Hepatol Res. 37
  
  Pages: 299-302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Inhibition of nuclear factor-kappa B induces inflammatory cell migration and exacerbates severe liver injury in hepatitis B virus transgenic mice.2007
- Author(s)
  Satake S, Nagaki M, Kimura K, Moriwaki H.
- Journal Title
  
  Hepatology Research 37(7)
  
  Pages: 524-30
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Synergistic Growth Inhibition by Acyclic Retinoid and Vitamin K2 in Human Hepatoccllular Carcinoma Cells2007
- Author(s)
  Kanamori T, Shimizu M., Okuno M., Matsushima-Nishiwaki R, Tsurumi H, Kojima S, Moriwaki H
- Journal Title
  
  Cancer Sci 98
  
  Pages: 431-437
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590584
[Journal Article] Significant effect of hepatitis C virus specific CTLs on viral clearance in patients with type C chronic hepatitis treated with antiviral agents2007
- Author(s)
  Satake S, Nagaki M, Kimura K, Naiki T, Hayashi H, Sugihara J, Tomita E, Moriwaki H.
- Journal Title
  
  Hepatol Res
- NAID
  10024148453
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Prevention of hepatic fibrosis in nonobese diabetic mice : a critical role for interferon-γ2006
- Author(s)
  Mukai T, Nagaki M, Imose M, Kimura K, Satake S, Takai S, Moriwaki H.
- Journal Title
  
  Liver Int 26
  
  Pages: 1006-1014
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590585
[Journal Article] Acyclic retinoid, a novel synthetic retinoid, induces growth inhibition, apoptosis, and changes in mRNA expression of cell cycle-and differentiation-related molecules in human colon carcinoma cells.2006
- Author(s)
  Suzui M, Moriwaki H, (他3名)
- Journal Title
  
  Int J Oncol 28
  
  Pages: 1193-1199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Pathogenic role of B cells in anti-CD40-induced necroinflammatory liver disease2006
- Author(s)
  Kimura K, Moriwaki H, Nagaki M, Saio M, Nakamoto Y, Naito M, Kuwata K, Chisari FV.
- Journal Title
  
  Am J Pathol 168(3)
  
  Pages: 786-95
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Dual effects of heat stress on tumor necrosis factor-α-induced hepatocyte apoptosis in mice2006
- Author(s)
  Imao M, Nagaki M, Moriwaki H.
- Journal Title
  
  Lab Invest 86
  
  Pages: 959-967
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590585
[Journal Article] Prevention of hepatic fibrosis in nonobese diabetic mice : a critical role for interferon-gamma2006
- Author(s)
  Mukai T, Nagaki M, Imose M, Kimura K, Satake S, Takai S, Moriwaki H.
- Journal Title
  
  Liver Int 26(8)
  
  Pages: 1006-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Role of macrophage migration inhibitory factor in hepatitis B virus-specific cytotoxic-T-lymphocyte-induced liver injury2006
- Author(s)
  Kimura K, Nagaki M, Nishihira J, Satake S, Kuwata K, Moriwaki H.
- Journal Title
  
  Clin Vaccine Immunol 13(3)
  
  Pages: 415-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Overweight and obesity increase the risk for liver cancer in patients with liver cirrhosis and long-term oral supplementation with branched-chain amino acid granules inhibits liver carcinogenesis in heavier patients with liver cirrhosis.2006
- Author(s)
  Muto Y, Moriwaki H, Nishiguchi S, (他9名)
- Journal Title
  
  Hepatol Res 35
  
  Pages: 204-214
- NAID
  10018775034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Prevention of second primary tumors by an acyclic retinoid in patients with hepatocellular carcinoma.2005
- Author(s)
  Takai K, Moriwaki H, (他7名)
- Journal Title
  
  Intervirology 48
  
  Pages: 39-45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Blockade of neutrophil elastase attenuates severe liver injury in hepatitis B transgenic mice2005
- Author(s)
  Takai S, Kimura K, Nagaki M, Satake S, Kakimi K, Moriwaki H.
- Journal Title
  
  J Virol 79(24)
  
  Pages: 15142-50
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Liver injury induced by lipopolysaccharide is mediated by TNFR-1 but not by TNFR-2 or Fas in mice2005
- Author(s)
  Shimizu S, Yamada Y, Okuno M, Ohnishi H, Osawa Y, Seishima M, Moriwaki H
- Journal Title
  
  Hepatol Res 31
  
  Pages: 136-142
- NAID
  10016478673
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590585
[Journal Article] Weinstein I B : (-)-Epigallocatechin gallate and polyphenon E inhibit growth and activation of the epidermal growth factor receptor and human epidermal growth factor receptor-2 signaling pathways in human colon cancer cells2005
- Author(s)
  Shimizu M, Deguchi A, Lim J T, Moriwaki H, Kopclovich L
- Journal Title
  
  Clin Cancer Res 11
  
  Pages: 2735-2746
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590584
[Journal Article] Normal liver regeneration and liver cell apoptosis after partial hepatectomy in tumor necrosis factor-alpha-deficient mice2005
- Author(s)
  Hayashi H, Nagaki M, Imose M, Osawa Y, Kimura K, Takai S, Imao M, Naiki T, Kato T, Moriwaki H.
- Journal Title
  
  Liver Int 25(1)
  
  Pages: 162-70
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Augmentation of lipopolysaccharide-induced nitric oxide production by α-galactosylceramide in mouse peritoneal cells2005
- Author(s)
  Ito H, Koide N, Morikawa A, Hassan F, Islam S, Tumurkhuu G, Mori I, Yosida T, Kakumu S, Moriwaki H, Yokochi T
- Journal Title
  
  J Endotoxin Res 11
  
  Pages: 213-219
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590585
[Journal Article] Prevention of rat hepatocarcinogenesis by acyclic retinoid is accompanied by reduction in emergence of both TNF-a-expressing oval-like cells and activated hepatic stellate cells2005
- Author(s)
  Sano T, Kagawa M, Okuno M, Ishibashi N, Hashimoto M, Yamamoto M, Suzuki R, Kohno H, Kojima S, Friedman SL, Moriwaki H, Tanaka T
- Journal Title
  
  Nutr Cancer 51
  
  Pages: 197-206
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590585
[Journal Article] Prevention of second primary tumors by an acyclic retinoid in patients with hepatocellular carcinoma. Updated analysis of the long-term follow-up data.2005
- Author(s)
  Moriwaki, H, et al.
- Journal Title
  
  Intervirology 48
  
  Pages: 39-45
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Prevention of rat hepatocarcinogenesis by acyclic retinoid is accompanied by reduction in emergence of both TNF-a- expressing oval-like cells and activated hepatic stellate cells.2005
- Author(s)
  Sano T, Kojima S, Moriwaki H, Tanaka T, (他11名)
- Journal Title
  
  Nutr Cancer 51
  
  Pages: 197-206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Prevention of rat hepatocarcinogenesis by acyclic retinoid is accompanied by reduction in emergence of both TGF-alpha-expressing oval-like cells and activated hepatic stellate cells.2005
- Author(s)
  Moriwaki, H., Tanaka, T., et al.
- Journal Title
  
  Nutr Cancer 51
  
  Pages: 191-206
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Effects of oral branched-chain amino acid granules on event-free survival in patients with liver cirrhosis.2005
- Author(s)
  Moriwaki, H., Nishiguchi, S., et al.
- Journal Title
  
  Clin Gastroenterol Hepatol 3
  
  Pages: 705-713
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Acyclic retinoid, NIK-333, inhibits N-diethylnitrosamine-induced rat hepatocarcinogenesis through suppression of TGF-α expression and cell proliferation.2004
- Author(s)
  Kagawa M, Sano T, Ishibashi N, Hashimoto M, Okuno M, Moriwaki H, Suzuki R, Kohno H, Tanaka T
- Journal Title
  
  Carcinogenesis 25
  
  Pages: 979-985
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570457
[Journal Article] The ring finger protein, RNF8, interacts with retinoid X receptor α and enhances its transcription-stimulating activity.2004
- Author(s)
  Takano Y, Adachi S, Okuno M, Muto Y, Yoshioka T, Matsushima-Nishiwaki R, Tsurumi H, Ito K, Friedman SL, Moriwaki H, Kojima S, Okano Y
- Journal Title
  
  J Biol Chem 279
  
  Pages: 18926-18934
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570457
[Journal Article] Acyclc retinoid, NIK-333, inhibits N-diethyl nitrosamine-induced rat hepatocarcinogenesis through suppression of TGF-α expression and cell proliferation2004
- Author(s)
  Kagawa M, Sano T, Ishibashi N, Hashimoto M, Okuno M, Moriwaki H, Suzuki R, Kohno H, Tanaka T
- Journal Title
  
  Carcinogenesis 25
  
  Pages: 979-985
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590585
[Journal Article] Acyclic retinoid in the chemoprevention of hepatocellular carcinoma2004
- Author(s)
  Kojima S, Okuno M, Matsushima-Nishiwaki R, Friedman SL, Moriwaki H
- Journal Title
  
  Int J Oncol 24
  
  Pages: 797-805
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590585
[Journal Article] The ring finger protein, RNF8, interacts with retinoid X receptor α and enhances its transcription-stimulating activity2004
- Author(s)
  Takano Y, Adachi S, Okuno M, Muto Y, Yoshioka T, Matsushima-Nishiwaki R, Tsurumi H, Ito K, Friedman SL, Moriwaki H, Kojima S, Okano Y
- Journal Title
  
  J Biol Chem 279
  
  Pages: 18926-18934
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590585
[Journal Article] Molecular mechanism for growth suppression of human hepatocellular carcinoma cells by acyclic retinoid2003
- Author(s)
  Matsushima-Nishiwaki R, Okuno M, Takano Y, Kojima S, Friedman SL, Moriwaki H
- Journal Title
  
  Carcinogenesis 24
  
  Pages: 1353-1359
- NAID
  110002843034
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590585
[Journal Article] Acyclic retinoid induces partial differentiation, down-regulates telomerase reverse transcriptase mRNA expression and telomerase activity, and induces apoptosis in human hepatoma-derived cell lines.2002
- Author(s)
  Yasuda I, Shiratori Y, Adachi S, Obora A, Takemura M, Okuno M, Shidoji Y, Seishima M, Muto Y, Moriwaki H
- Journal Title
  
  J Hepatol 36
  
  Pages: 660-671
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570457
[Journal Article] Synergistic induction of apoptosis by acyclic retinoid and interferon-b in human hepatocellular carcinoma cells.2002
- Author(s)
  Obora A, Shiratori Y, Okuno M, Adachi S, Takano Y, Matsushima-Nishiwaki R, Yasuda I, Yamada Y, Akita K, Sano T, Shimada J, Kojima S, Okano Y, Friedman SL, Moriwaki H
- Journal Title
  
  Hepatology 36
  
  Pages: 1115-1124
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570457
[Journal Article] Intrahepatic cholangiocarcinoma arising 10 years after the excision of congenital extrahepatic biliary dilation : A case report.2002
- Author(s)
  Goto N, Yasuda I, Uematsu T, Kanemura N, Takai S, Ando K, Kato T, Osada S, Takao H, Saji S, Shimokawa K, Moriwaki H
- Journal Title
  
  J Gastroenterol 36
  
  Pages: 856-862
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570457
[Presentation] 肝硬変における骨格筋変化率が予後に及ぼす影響についての検討2015
- Author(s)
  華井竜徳、白木　亮、大西祥代、森脇久隆、清水雅仁
- Organizer
  JDDW2015（第19回日本肝臓学会大会）
- Place of Presentation
  東京
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-25460988
[Presentation] Preventive effects of branched-chain amino acid supplementation on the spontaneous development of hepatic preneoplastic lesions in C57BL/KsJ-db/db obese mice.2015
- Author(s)
  Ideta T, Terakura D, Shimizu M, Miyazaki T, Kochi T, Sakai H, Shirakami Y, Tanaka T, Moriwaki H.
- Organizer
  106th American Association for Cancer Research (AACR) Annual Meeting
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460988
[Presentation] The role of the phosphorylated RXR-alpha on cellular proliferation and liver tumorigenesis.2015
- Author(s)
  Sakai H, Shirakami Y, Shimizu M, and Moriwaki H
- Organizer
  106th American Association for Cancer Research (AACR) Annual Meeting
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460988
[Presentation] ワークショップ8「生活習慣と肝病態の変遷：明日の肝臓病学に向けて」生活習慣病治療薬を用いた肥満・糖尿病関連肝発癌の抑制2014
- Author(s)
  清水雅仁　　森脇久隆
- Organizer
  JDDW2014（第18回日本肝臓学会大会）
- Place of Presentation
  神戸
- Year and Date
  2014-10-24
- Data Source
  KAKENHI-PROJECT-25460988
[Presentation] Preventive effects of branched-chain amino acids supplementation on the spontaneous development of hepatic preneoplastic lesions in C57BL/KsJ-db/db obese mice2013
- Author(s)
  Shimizu M, Terakura D, Kochi T, Ohno T, Kubota M, Shirakami Y, Tanaka T, Moriwaki H
- Organizer
  104th AACR (American Association for Cancer Research) Annual Meeting
- Place of Presentation
  Washington, DC, USA
- Data Source
  KAKENHI-PROJECT-25460987
[Presentation] シンポジウム「レチノイド研究温故知新―レチノイドの新たな作用点を求めて―」非環式レチノイドによる肝発癌化学予防 ―Chemoprevention of hepatocellular carcinoma by acyclic retinoid―2013
- Author(s)
  清水雅仁、森脇久隆
- Organizer
  日本レチノイド研究会第24回学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] パネルディスカッション1「C型肝炎を背景とした肝細胞癌―予防から再発治療まで―」非環式レチノイドと分岐鎖アミノ酸を用いた肝発癌抑制―肥満関連肝発癌抑制と両剤の併用投与による相乗的肝癌細胞増殖抑制―2013
- Author(s)
  清水雅仁、白上洋平、森脇久隆
- Organizer
  JDDW2013
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460987
[Presentation] パネルディスカッション1「C型肝炎を背景とした肝細胞癌―予防から再発治療まで―」非環式レチノイドと分岐鎖アミノ酸を用いた肝発癌抑制―肥満関連肝発癌抑制と両剤の併用投与による相乗的肝癌細胞増殖抑制―2013
- Author(s)
  清水雅仁、白上洋平、森脇久隆
- Organizer
  JDDW2013
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460988
[Presentation] パネルディスカッション1「C型肝炎を背景とした肝細胞癌―予防から再発治療まで―」非環式レチノイドと分岐鎖アミノ酸を用いた肝発癌抑制―肥満関連肝発癌抑制と両剤の併用投与による相乗的肝癌細胞増殖抑制―．2013
- Author(s)
  清水雅仁、白上洋平、森脇久隆．
- Organizer
  JDDW2013
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] ワークショップ「炎症および傷害物質に関連した発がんと予防」非アルコール性脂肪肝炎関連肝発癌新規モデルとペントキシフィリンによる発癌抑制効果2013
- Author(s)
  白上洋平、清水雅仁、森脇久隆、清島満
- Organizer
  第20回日本がん予防学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460988
[Presentation] シンポジウム「レチノイド研究温故知新―レチノイドの新たな作用点を求めて―」非環式レチノイドによる肝発癌化学予防 ―Chemoprevention of hepatocellular carcinoma by acyclic retinoid―2013
- Author(s)
  清水雅仁、森脇久隆
- Organizer
  日本レチノイド研究会第24回学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460987
[Presentation] ワークショップ「胆汁酸研究の最新のシンポ」胆汁酸による肝細胞障害および肝線維化におけるTNF-αの役割2013
- Author(s)
  清水雅仁、寺倉大志、森脇久隆
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] ワークショップ「炎症および傷害物質に関連した発がんと予防」肝および内臓脂肪の炎症制御を介した分岐鎖アミノ酸による肥満・糖尿病関連肝腫瘍形成の抑制2013
- Author(s)
  清水雅仁、寺倉大志、河内隆宏、白上洋平、田中卓二、森脇久隆
- Organizer
  第20回日本がん予防学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460987
[Presentation] ワークショップ「炎症および傷害物質に関連した発がんと予防」肝および内臓脂肪の炎症制御を介した分岐鎖アミノ酸によるNAFLD関連肝腫瘍形成の抑制2013
- Author(s)
  清水雅仁、寺倉大志、河内隆宏、白上洋平、田中卓二、森脇久隆
- Organizer
  第20回日本がん予防学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460988
[Presentation] NASH・肥満関連分子異常を標的とした肝癌再発予測と肝発癌化学予防2013
- Author(s)
  清水雅仁、森脇久隆
- Organizer
  JDDW2013
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460987
[Presentation] ワークショップ「炎症および傷害物質に関連した発がんと予防」肝および内臓脂肪の炎症制御を介した分岐鎖アミノ酸による肥満・糖尿病関連肝腫瘍形成の抑制2013
- Author(s)
  清水雅仁、寺倉大志、河内隆宏、白上洋平、田中卓二、森脇久隆
- Organizer
  第20回日本がん予防学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] ワークショップ「炎症および傷害物質に関連した発がんと予防」非アルコール性脂肪肝炎関連肝発癌新規モデルとペントキシフィリンによる発癌抑制効果2013
- Author(s)
  白上洋平、清水雅仁、森脇久隆、清島満
- Organizer
  第20回日本がん予防学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] NASH・肥満関連分子異常を標的とした肝癌再発予測と肝発癌化学予防2013
- Author(s)
  清水雅仁、森脇久隆
- Organizer
  JDDW2013
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460988
[Presentation] Chemoprevention of obesity- and diabetes-related liver carcinogenesis by branched-chain amino acids and acyclic retinoid2013
- Author(s)
  Shimizu M, Moriwaki H
- Organizer
  The 3rd AACR International Conference on Frontiers in Basic Cancer Research
- Place of Presentation
  National Harbor, MD, USA
- Data Source
  KAKENHI-PROJECT-25460987
[Presentation] Chemoprevention of obesity- and diabetes-related liver carcinogenesis by branched-chain amino acids and acyclic retinoid2013
- Author(s)
  Shimizu M, Moriwaki H
- Organizer
  The 3rd AACR International Conference on Frontiers in Basic Cancer Research
- Place of Presentation
  National Harbor, MD, USA
- Data Source
  KAKENHI-PROJECT-25460988
[Presentation] シンポジウム「レチノイド研究温故知新―レチノイドの新たな作用点を求めて―」非環式レチノイドによる肝発癌化学予防 ―Chemoprevention of hepatocellular carcinoma by acyclic retinoid―2013
- Author(s)
  清水雅仁、森脇久隆
- Organizer
  日本レチノイド研究会第24回学術集会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-25460988
[Presentation] Preventive effects of branched-chain amino acids supplementation on the spontaneous development of hepatic preneoplastic lesions in C57BL/KsJ-db/db obese mice2013
- Author(s)
  Shimizu M, Terakura D, Kochi T, Ohno T, Kubota M, Shirakami Y, Tanaka T, Moriwaki H
- Organizer
  104th AACR (American Association for Cancer Research) Annual Meeting
- Place of Presentation
  Washington, DC, USA
- Data Source
  KAKENHI-PROJECT-25460988
[Presentation] ワークショップ「炎症および傷害物質に関連した発がんと予防」非アルコール性脂肪肝炎関連肝発癌新規モデルとペントキシフィリンによる発癌抑制効果2013
- Author(s)
  白上洋平、清水雅仁、森脇久隆、清島満
- Organizer
  第20回日本がん予防学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460987
[Presentation] Symposia「Diabetes and Cancer」Targeting obesity- and diabetes-related metabolic abnormalities for chemoprevention of hepatocellular carcinoma.2012
- Author(s)
  Shimizu M, Moriwaki H
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-21
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] ワークショップ8「消化器疾患と胆汁酸」非環式レチノイドとGW4064(FXR ligand)併用による肝癌抑制効果2012
- Author(s)
  大野智彦、清水雅仁、森脇久隆
- Organizer
  JDDW2012（第54回日本消化器病学会大会）
- Place of Presentation
  神戸
- Year and Date
  2012-10-10
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] シンポジウム「ビタミン誘導体の臨床応用」非環式レチノイドによる肝発癌化学予防#8212;リン酸化RXRaを標的分子とした肝発癌化学予防#8212;2012
- Author(s)
  清水雅仁、森脇久隆
- Organizer
  日本ビタミン学会第64回大会
- Place of Presentation
  岐阜
- Year and Date
  2012-06-22
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] ワークショップ8「NASH/NAFLDから進展する肝硬変・肝癌の現状と対応」非アルコール性肝脂肪化におけるトリプトファンの影響2012
- Author(s)
  大澤陽介、森脇久隆、清島　満
- Organizer
  第48回日本肝臓学会総会
- Place of Presentation
  金沢
- Year and Date
  2012-06-07
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] ワークショップ10「肝細胞癌の発症と再発予防を目指した慢性肝炎の治療」栄養的および薬剤投与介入による肥満関連肝発癌予防の可能性#8212;BCAAと非環式レチノイドを用いて#8212;2012
- Author(s)
  清水雅仁、白木　亮、森脇久隆
- Organizer
  第48回日本肝臓学会総会
- Place of Presentation
  金沢
- Year and Date
  2012-06-07
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] ワークショップ7「Steatohepatitisの病態～その多様性と相同性～」非環式レチノイドによる肥満関連肝腫瘍形成の抑制2011
- Author(s)
  清水雅仁、森脇久隆
- Organizer
  第97回日本消化器病学会総会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-21590838
[Presentation] シンポジウム15「肝硬変患者の栄養マネージメント、治療」肝硬変患者におけるエネルギー低栄養状態の指標としてのパラメーターの検討～呼吸商の代替として～2011
- Author(s)
  寺倉陽一、白木亮、森脇久隆
- Organizer
  JDDW2011(第15回日本肝臓学会大会)
- Place of Presentation
  福岡
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-21590838
[Presentation] シンポジウム「がん予防戦略の最前線」肥満関連分子異常を標的とした肝発癌化学予防2011
- Author(s)
  清水雅仁、森脇久隆
- Organizer
  がん予防大会2011京都
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21590838
[Presentation] シンポジウム14「代謝性・遺伝性肝疾患研究の進歩」肝臓の糖・脂質代謝における酸性スフィンゴミエリナーゼの役割2011
- Author(s)
  大澤陽介、森脇久隆、清島満
- Organizer
  JDDW2011(第15回日本肝臓学会大会)
- Place of Presentation
  福岡
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-21590838
[Presentation] ワークショップ18「消化器疾患におけるprobioticsと機能性食品の有用性」緑茶カテキンを用いた肥満関連大腸および肝発癌予防2011
- Author(s)
  清水雅仁、久保田全哉、森脇久隆
- Organizer
  JDDW 2011(第53回日本消化器病学会大会)
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-21590838
[Presentation] ワークショップ18「消化器疾患におけるprobioticsと機能性食品の有用性」緑茶カテキンを用いた肥満関連大腸および肝発癌予防2011
- Author(s)
  清水雅仁、久保田全哉、森脇久隆
- Organizer
  JDDW2011(第53回日本消化器病学会大会)
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-21590838
[Presentation] ワークショップ7「Steatohepatitisの病態.その多様性と相同性.」非環式レチノイドによる肥満関連肝腫瘍形成の抑制2011
- Author(s)
  清水雅仁、森脇久隆
- Organizer
  第97回日本消化器病学会総会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-21590838
[Presentation] ワークショップ5「肝発癌・進展とインスリン抵抗性」インスリン抵抗性とIGF/IGF-1受容体シグナルを標的とした肥満関連肝発癌予防2010
- Author(s)
  清水雅仁、岩砂淳平、森脇久隆
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-21590838
[Presentation] シンポジウム2「消化器癌と栄養療法」分枝鎖アミノ酸製剤(BCAA)を用いた肥満関連肝および大腸発癌の予防2010
- Author(s)
  清水雅仁、白木亮、森脇久隆
- Organizer
  第96回日本消化器病学会総会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-21590838
[Presentation] ワークショップ3「大腸癌の予防」緑茶カテキンによる大腸発癌予防-基礎および臨床的予備実験-2009
- Author(s)
  清水雅仁、森脇久隆
- Organizer
  第95回日本消化器病学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21590838
[Presentation] パネルディスカッション14「肝細胞癌の集学的治療の現状と近未来的治療(分子標的治療を含めて)」RXRαを標的分子とする非環式レチノイドを用いた併用肝発癌化学予防2009
- Author(s)
  清水雅仁、久保田全哉、森脇久隆
- Organizer
  JDDW2009
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21590838
[Presentation] ワークショップ4「肝細胞癌の予防」核内受容体RXRαを分子標的とする非環式レチノイドをkey drugとした併用肝発癌化学予防2009
- Author(s)
  清水雅仁、森脇久隆
- Organizer
  第95回日本消化器病学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21590838
[Presentation] シンポジウム5「メタボリック症候群と消化器癌」分枝鎖アミノ酸製剤(BCAA)による肥満関連肝発癌の抑制2009
- Author(s)
  岩砂淳平、清水雅仁、森脇久隆
- Organizer
  第95回日本消化器病学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21590838
[Presentation] ワークショップ23-1「Cancer prevention/chemoprevention」Supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver carcinogenesis in obese mice2009
- Author(s)
  Shimizu M, Iwasa J, Tanaka T, Moriwaki H
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21590838
[Presentation] Synergistic growth inhibition by 9-cis-retinoic acid plus trastuzumab in human hepatocellular carcinoma cells.2008
- Author(s)
  Tatebe H, Shimizu M, Moriwaki H
- Organizer
  99th AACR (American Association for Cancer Research) Annual Meeting
- Place of Presentation
  アメリカ
- Year and Date
  2008-04-15
- Data Source
  KAKENHI-PROJECT-17015016
[Presentation] レチノイドとTrastuzumabの併用処理による相乗的な肝癌細胞増殖抑制効果の検討2008
- Author(s)
  建部英春, 清水雅仁, 森脇久隆
- Organizer
  第44回日本肝臓学会総会
- Place of Presentation
  松山
- Year and Date
  2008-06-05
- Data Source
  KAKENHI-PROJECT-17015016
[Presentation] Critical role of CD44 in Hepatotoxin mediated liver injury2008
- Author(s)
  Kiminori Kimura, Masahito nagaki, Kazuhiro Kakimi, Hisataka Moriwaki
- Organizer
  AASLD
- Place of Presentation
  Boston, USA
- Year and Date
  2008-11-05
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590628
[Presentation] パネルディスカッション8「肝癌再発進展阻止を目指して」レテノイド核内受容体RXRαを標的分子とした肝細胞癌化学予防-非環式レチノイドとclonal deletion-2008
- Author(s)
  清水雅仁, 森脇久隆
- Organizer
  第94回日本消化器病学会総会
- Place of Presentation
  福岡
- Year and Date
  2008-05-09
- Data Source
  KAKENHI-PROJECT-19590720
[Presentation] シンポジウム肝がん予防の総合戦略と化学予防2008
- Author(s)
  森脇久隆
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-17015016
[Presentation] シンポジウム肝がん予防の総合戦略と化学予防2008
- Author(s)
  清水雅仁、森脇久隆
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19590720
[Presentation] シンポジウム6「肝癌の分子標的治療」Retinoid核内受容体RXRαを標的分子としたAcyclic retinoidによる肝癌化学予防2008
- Author(s)
  清水雅仁、森脇久隆
- Organizer
  JDDW2008
- Place of Presentation
  東京
- Year and Date
  2008-10-01
- Data Source
  KAKENHI-PROJECT-19590720
[Presentation] Synergistic growth inhibition by 9-cis-retinoic acid plus trastuzumab in human hepatocellular carcinoma cells2008
- Author(s)
  Tatebe H, Shimizu M, Shirakami Y, Tsurumi H, Moriwaki H
- Organizer
  99^<th> AACR(American Association for Cancer Research)Annual Meeting
- Place of Presentation
  サンディエゴ
- Year and Date
  2008-04-15
- Data Source
  KAKENHI-PROJECT-19590720
[Presentation] パネルティスカッション8「肝癌再発進展阻止を目指して」レチノイド核内受容体RXRαを標的分子とした肝細胞癌化学予防-非環式レチノイドとclonal deletion-2008
- Author(s)
  清水雅仁、森脇久隆
- Organizer
  第94回日本消化器病学会総会
- Place of Presentation
  福岡
- Year and Date
  2008-05-09
- Data Source
  KAKENHI-PROJECT-17015016
[Presentation] レチノイドとTrastuzumabの併用処理による相乗的な肝癌細胞増殖抑制効果の検討2008
- Author(s)
  建部英春、清水雅仁、森脇久隆
- Organizer
  第44回日本肝臓学会総会
- Place of Presentation
  松山
- Year and Date
  2008-06-05
- Data Source
  KAKENHI-PROJECT-19590720
[Presentation] パネルディスカッション8「肝癌再発進展阻止を目指して」レチノイド核内受容体RXRαを標的分子とした肝細胞癌化学予防-非環式レチノイドとclonal deletion-.2008
- Author(s)
  清水雅仁, 森脇久隆
- Organizer
  第94回日本消化器病学会総会
- Place of Presentation
  福岡
- Year and Date
  2008-05-09
- Data Source
  KAKENHI-PROJECT-17015016
[Presentation] パネルディスカッション8「肝癌再発進展阻止を目指して」レチノイド核内受容体RXRαを標的分子とした肝細胞癌化学予防-非環式レチノイドとclonal deletion-2008
- Author(s)
  森脇久隆
- Organizer
  第94回日本消化器病学会総会
- Place of Presentation
  福岡
- Year and Date
  2008-05-09
- Data Source
  KAKENHI-PROJECT-19590720
[Presentation] シンポジウム6「肝癌の分子標的治療」Retinoid核内受容体RXRαを標的分子としたAcyclic retinoidによる肝癌化学予防2008
- Author(s)
  清水雅仁, 森脇久隆
- Organizer
  JDDW2008
- Place of Presentation
  東京
- Year and Date
  2008-10-01
- Data Source
  KAKENHI-PROJECT-17015016
[Presentation] シンポジウム6「肝癌の分子標的治療」Retino id核内受容体RXRαを標的分子としたAcyclic retinoidによる肝癌化学予防2008
- Author(s)
  清水雅仁, 森脇久隆
- Organizer
  JDDW2008
- Place of Presentation
  東京
- Year and Date
  2008-10-01
- Data Source
  KAKENHI-PROJECT-19590720
[Presentation] シンポジウム肝がん予防の総合戦略と化学予防2008
- Author(s)
  森脇久隆
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19590720
[Presentation] ワークショップ100%の適用を目指したミニセット型電子クリニカルパス2008
- Author(s)
  白島義宗, 内木隆文, 森脇久隆
- Organizer
  第94回日本消化器病学会総会
- Place of Presentation
  福
- Year and Date
  2008-05-10
- Data Source
  KAKENHI-PROJECT-20590507
[Presentation] Strategy and mechanism for the prevention of hepatocellular carcinoma(HCC)-Phosphorylated RXRα might be a critical target for HCC chemoprevention-2007
- Author(s)
  Shimizu M, Moriwaki H.
- Organizer
  The 8th Japan-Korea Cancer and Ageing Symposium
- Place of Presentation
  岐阜
- Year and Date
  2007-08-11
- Data Source
  KAKENHI-PROJECT-19590720
[Presentation] 四塩化炭素を用いた肝障害モデルにおけるCD44の役割2007
- Author(s)
  木村公則、永木正仁、垣見和宏、森脇久隆
- Organizer
  日本肝臓学会
- Place of Presentation
  大阪
- Year and Date
  2007-03-06
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590628
[Presentation] RXRのリン酸化修飾がRXR/RAR二量体形成能に及ぼす影響についての検討2007
- Author(s)
  吉村光太郎、清水雅仁、西脇理英、奥野正隆、小嶋聡一、武藤吉徳、森脇久隆
- Organizer
  日本レチノイド研究会第18回学術集会
- Place of Presentation
  東京
- Year and Date
  2007-11-24
- Data Source
  KAKENHI-PROJECT-19590720
[Presentation] ヒト大腸癌におけるRXRαのリン酸化とRXR/PPARγリガンド併用処理による大腸癌細胞増殖抑制効果の検討2007
- Author(s)
  山崎健路、清水雅仁、西脇理英、奥野正隆、小嶋聡一、森脇久隆
- Organizer
  日本レチノイド研究会第18回学術集会
- Place of Presentation
  東京
- Year and Date
  2007-11-24
- Data Source
  KAKENHI-PROJECT-19590720
[Presentation] Synergistic growth inhibition by 9-cis-retinoic acid plus trastuzumab in human hepatocellular carcinoma cells2007
- Author(s)
  Tatebe H, Shimizu M, Shirakami Y, Sakai H, Moriwaki H.
- Organizer
  The 8^<th> Japan-Korean Cancer and Ageing Symposium
- Place of Presentation
  岐阜
- Year and Date
  2007-08-11
- Data Source
  KAKENHI-PROJECT-19590720
[Presentation] Synergistic growth inhibition by 9-cisretinoic acid plus trastuzumab in human hepatocellular carcinoma cells.2007
- Author(s)
  Tatebe H, Shimizu M, Moriwaki H
- Organizer
  The 8th Japan-Korea Cancer and Ageing Symposium
- Place of Presentation
  岐阜
- Year and Date
  2007-08-11
- Data Source
  KAKENHI-PROJECT-17015016
[Presentation] ワークショップ5「肝細胞癌根治療法後の再発抑制」非環式レチノイドとビタミンK2の併用処理による相乗的な肝癌細胞増殖抑制効果の検討2007
- Author(s)
  金森堂、清水雅仁、森脇久隆
- Organizer
  第93回日本消化器病学会総会
- Place of Presentation
  青森
- Year and Date
  2007-04-21
- Data Source
  KAKENHI-PROJECT-19590720
[Presentation] ワークショップ5「肝細胞癌根治療法後の再発抑制」非環式レチノイドとビタミンK2の併用処理による相乗的な肝癌細胞増殖抑制効果の検討2007
- Author(s)
  金森堂, 清水雅仁, 森脇久隆
- Organizer
  第93回日本消化器病学会総会
- Place of Presentation
  青森
- Year and Date
  2007-04-21
- Data Source
  KAKENHI-PROJECT-17015016
[Presentation] Crucial role of CD44 in liver injury2007
- Author(s)
  kiminori kimura, Masahito nagaki, Kazuhiro Kakimi, Toshinori Nakayama, Masaru Taniguchi and Hisataka Moriwaki
- Organizer
  AAI
- Place of Presentation
  San Diego, USA
- Year and Date
  2007-04-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590628

1. SHIDOJI Yoshihiro (00111518)

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Moriwaki Hisataka 森脇 久隆

MORIWAKI Hisataka 森脇 久隆

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レチノイド核内受容体RXRα遺伝子改変マウスを用いた肝発癌機序の解析Principal Investigator

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Combination chemoprevention of hepatocellular carcinoma with acyclic retinoid by targeting RXRαphosphorylationPrincipal Investigator

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Strategy for chemoprevention of digestive cancers by targeting abnormalities in receptor tyrosine kinases and nuclear receptorsPrincipal Investigator

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Strategy for the chemoprevention of hepatocellular carcinoma by targeting phosphorylated RXRaPrincipal Investigator

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The role of cytokine cascade in impaired liver regeneration and development of candidate pharmaceutical(s) to regulate this mechanismPrincipal Investigator

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核受容体蛋白を標的分子としたがん化学予防の研究Principal Investigator

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Moriwaki Hisataka 森脇久隆

MORIWAKI Hisataka 森脇久隆