OKANO Yukio 岡野幸雄

Researcher Number	10177066
Other IDs
Affiliation (based on the past Project Information) *help	2012: 岐阜大学, 医学系研究科, 教授 2009: 岐阜大学, 医学系研究科, 教授 2007 – 2009: 岐阜大学, 大学院・医学系研究科, 教授 2006: 岐阜大学, 大学院医学系研究科, 教授 2005: Gifu University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 … More
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Biological Sciences / General medical chemistry / Structural biochemistry Except Principal Investigator 代謝生物化学 / Biological Sciences / Pathological medical chemistry / Circulatory organs internal medicine / Functional biochemistry / Gastroenterology / General medical chemistry / Cell biology / Cerebral neurosurgery
Keywords	Principal Investigator dominant negative / centrosome / cell cycle / breast cancer / chromosome mapping / RING-finger / ipl-related kinase) / RNF8 / FRET / yeast two-hybrid … More Except Principal Investigator 表皮細胞 / 化学予防 / 分化誘導 / apoptosis / レチノイド / ガングリオシド / centrosome / histone H3 / 核内受容体 / phosphorylation / Aurora / GQ1b / ホスホリパ-ゼC / GTP結合蛋白質 / NEK / cell division / アポトーシス / ホスホリパーゼC / シグナル伝達 / INTERFERON / Human Platelets / G蛋白質活性化因子 / Gタンパク質 / クローン除去 / Peptide growth factor / membrane fluidity / 細胞死 / トランスグルタミナーゼ / DNA ladder / electron microscopy / H_2O_2 / Aurora(AIK) / smooth muscle cells / 非環式レチノイド / Phospolipase C / intimal hyperplasia / 情報変換酵素 / fatty acid desaturase / TUNEL / Pertussis toxin-sensitive GTP-binding protein / 生体膜脂質 / hypoxia / ホスフォリパ-ゼC / 細胞増殖因子 / 情報伝達 / serum deprivation / 3次元立体像 / テトラヒメナ / Signaltransduction / CLONAL DELETION / 蛍光共鳴エネルギー移動 / 肺発癌予防 / バルーン障害モデル / 肝臓癌 / 転写制御 / GQlb / bax mRNA / リン酸化・非リン酸化RXR / PC12 / C6cell / H202 / 百日咳毒素感受性G蛋白質 / 遺伝子導入 / 発癌 / low-temperature-shift / PC-12cell / 蛍光顕微鏡 / Phospholipase C / colorectal cancer / 膜物性修飾 / インターフェロン / 肝癌 / 核受容体 / 膜流動性 / Cキナ-ゼ / Human platelets / APOPTOSIS / HEPATOCELLULAR CARCINOMA / サザンブロッティング / cDNAクローニング / ユビキチン化 / GTP-binding protein / GTPase-activating protein / NUCLEAR RECEPTOR / G-蛋白質βγ / 遺伝子治療 / ラット頚動脈 / 低温シフト / DNA / dominant negative / RETINOID / リン酸化 / PI3-kinase / 血小板 / cell devision / レチノイ / 環境適応機構 / 核内受容体修飾異常 / FRET / mouth muscle cells / NP25 / G protein betagamma / がん / PI3キナ-ゼ / 細胞分裂 / p21^<ras>ーGTPア-ゼ活性化蛋白質 / 増殖能 / レチノイドレセプター / 肝発癌予防 / ヒト血小板 / オーロラキナーゼ / UBIQUITINATION / bladder cancer / Bax mRNA / 脂肪酸不飽和化酵素 / 14-3-3protein / Phosphatidylinositol-phospholipase C / 分子多様性 / 遺伝的解析 / phosphorvlation / Receptor tyrosine kinase / cell cycle / Protein kinase C / CANCER CHEMOPREVENTION / 分子標的 / 受容体チロシンキナ-ゼ / GFP / restenosis Less

Elucidation of the function of Aurora kinases in mitosis and itsdysregulation in cancer
- Principal Investigator
  
  KIMURA Masashi
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Gifu University
Strategy for the chemoprevention of hepatocellular carcinoma by targeting phosphorylated RXRa
- Principal Investigator
  
  MORIWAKI Hisataka
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
Interactions of the retinoid X receptor with a RING protein and its effects on ubiquitylation and transcriptionPrincipal Investigator
- Principal Investigator
  
  OKANO Yukio
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Gifu University
ヒトAuroraおよび細胞分裂関連蛋白質の機能解析Principal Investigator
- Principal Investigator
  
  岡野幸雄
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
3次元蛍光共鳴エネルギー移動法による細胞内タンパク質間相互作用の解析
- Principal Investigator
  
  武藤吉徳
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Gifu University
AIKキナーゼファミリーの癌細胞における発現と機能解析Principal Investigator
- Principal Investigator
  
  岡野幸雄
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
核受容体蛋白を標的分子としたがん化学予防の研究
- Principal Investigator
  
  MORIWAKI Hisataka
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
Molecular mechanism of steroid receptor ubiquitinationPrincipal Investigator
- Principal Investigator
  
  OKANO Yukio
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Gifu University
AIKキナーゼファミリーの癌細胞における発現と機能Principal Investigator
- Principal Investigator
  
  岡野幸雄
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
Expression of AIK family in normal and cancer tissues
- Principal Investigator
  
  YOSHIOKA Takashi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Gifu University
MODIFICATION OF GROWTH AND APOPTOSIS BY UBIQUITINATION IN HEPATOMA CELL
- Principal Investigator
  
  SHIRATORI Yoshimune
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  GIFU UNIVERSITY
中心体キナーゼAikファミリーのがん細胞における発現Principal Investigator
- Principal Investigator
  
  岡野幸雄
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Gifu University
脳虚血時における細胞死シグナル伝達機構の調節に関する検討-シグナル調節蛋白(14-3-蛋白質)の役割
- Principal Investigator
  
  野田伸司
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Gifu University
Gene therapy against restenosis after balloom injury using apoptosis inducer, bax
- Principal Investigator
  
  FUJIWARA Hisayoshi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gifu University
ヒト中心体キナーゼAikの細胞分裂における役割Principal Investigator
- Principal Investigator
  
  岡野幸雄
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Gifu University
Functional analysis of a novel human kinase, Aik, involved in chromosome segregation.Principal Investigator
- Principal Investigator
  
  OKANO Yukio
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Gifu University
新規ヒトユビキチン結合酵素遺伝子の単離と細胞機能における役割の解析Principal Investigator
- Principal Investigator
  
  岡野幸雄
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Gifu University
細胞増殖・癌化のシグナル伝達とリン脂質代謝Principal Investigator
- Principal Investigator
  
  岡野幸雄
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Gifu University
Analysis of molecular mechanisms for suppression of Thy-1 expression in ras-transformed cells.Principal Investigator
- Principal Investigator
  
  OKANO Yukio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Gifu University
Control mechanism of phospholipase C activity in human platelets
- Principal Investigator
  
  BANNO Yoshiko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  GIFU UNIVERSITY
ガングリオシドGQ1bによる表皮細胞の分化誘導機構
- Principal Investigator
  
  野沢義則
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Gifu University
ガングリオシドGQlbによる表皮細胞の分化誘導機構
- Principal Investigator
  
  野沢義則
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Gifu University
Activation regulatory mechanisms of signal-transducing phospholipases in differentiated megakaryoblastic leukemia cells.Principal Investigator
- Principal Investigator
  
  OKANO Yukio
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Gifu University
ガングリオシドGQ1bによる表皮細胞の分化誘導機構
- Principal Investigator
  
  NOZAWA Yoshinori
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Gifu University
Interaction of multiple phospholipase C and GTP-binding proteins in platelet signal transduction
- Principal Investigator
  
  NOZAWA Yoshinori
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  代謝生物化学
- Research Institution
  Gifu University
Regulation of mitogenic signaling pathways which involve the function of GTP-binding protein-Possible involvement of protein tyrosine phosphorylation.
- Principal Investigator
  
  KOHNO Michiaki
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  代謝生物化学
- Research Institution
  Gifu Pharmaceutical University
Adaptation mechanism of membrane lipids and its genetic control
- Principal Investigator
  
  NOZAWA Yoshinori
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  代謝生物化学
- Research Institution
  Gifu University

All 2013 2012 2011 2009 2007 2006 2005 2004

All Journal Article

[Journal Article] Identification of a Rho family specific guanine nucleotide exchange factor, FLJ00018, as a novel actin-binding protein2013
- Author(s)
  Sato, K., Handa, H., Kimura, M., Okano,Y., Nagaoka, H., Nagase, T., Sugiyama,T., Kitade, Y., and Ueda, H.
- Journal Title
  
  Cell Signal
  
  Volume: 25 Pages: 41-49
- DOI
  10.1016/j.cellsig.2012.09.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590331, KAKENHI-PROJECT-23590073, KAKENHI-PUBLICLY-23118513, KAKENHI-PROJECT-23659151
[Journal Article] Mitotic catastrophe and cell death induced by depletion of centrosomal proteins2013
- Author(s)
  Kimura, M., Yoshioka, T., Saio, M.,Banno, Y., Nagaoka, H., and Okano, Y
- Journal Title
  
  Cell Death Dis
  
  Volume: 4
- DOI
  10.1038/cddis.2013.108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590331, KAKENHI-PROJECT-23659151
[Journal Article] Growth suppression and mitotic defect inducedby JNJ-7706621, an inhibitor ofcyclin-dependent kinases and aurorakinases2012
- Author(s)
  Matsuhashi, A., Ohno, T., Kimura, M.,Hara, A., Saio, M., Nagano, A., Kawai,G., Saitou, M., Takigami, I., Yamada, K.,Okano, Y., and Shimizu, K
- Journal Title
  
  Curr. Cancer. Drug. Targets.
  
  Volume: 12 Pages: 625-639
- URL
  http://www.eurekaselect.com/98883/article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590331
[Journal Article] Plk1 is negatively regulated by RNF82011
- Author(s)
  Yoshioka, T., Kimura, M., Saio, M., Era,S., and Okano, Y
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 410 Pages: 57-6
- DOI
  10.1016/j.bbrc.2011.05.104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590331, KAKENHI-PROJECT-22590203
[Journal Article] Effects ofAZD1152, a selective Aurora B kinaseinhibitor, on Burkitt's and Hodgkin's lymphomas2011
- Author(s)
  Mori, N., Ishikawa, C., Senba, M.,Kimura, M., and Okano, Y.
- Journal Title
  
  Biochem. Pharmacol.
  
  Volume: 81 Pages: 1106-1115
- DOI
  10.1016/j.bcp.2011.02.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590331
[Journal Article] Aberrantpromoter hypermethylation of the CHFRgene in oral squamous cell carcinomas.2009
- Author(s)
  Baba, S., Hara, A., Kato, K., Long, N.K.,Hatano, Y., Kimura, M., Okano, Y.,Yamada, Y., and Shibata, T
- Journal Title
  
  Oncol. Rep.
  
  Volume: 22 Pages: 1173-1179
- URL
  http://www.spandidos-publications.com/or/22/5/1173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590331
[Journal Article] Phosphorylated retinoid X receptor alpha loses its heterodimeric activity with retinoic acid receptor beta.2007
- Author(s)
  Yoshimura K, Shimizu M, Kojima S, Okano Y, Moriwaki H, (他5名)
- Journal Title
  
  Cancer Sci 98
  
  Pages: 1868-1874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Structural and functional characterization of NP25, a single CH domain protein.2006
- Author(s)
  Kuwata H, Yoshioka T, Muto Y, Kuwata K, Okano Y.
- Journal Title
  
  Acta Sch Med Univ Gifu 54
  
  Pages: 1-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570093
[Journal Article] The RING finger peotein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation.2006
- Author(s)
  Plans V, Scheper J, Soler M, Loukili N, Okano Y, Thomson TM.
- Journal Title
  
  J Cell Biochem 97
  
  Pages: 572-582
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570093
[Journal Article] Itnmuno-FRET microscopy of the actin-binding protein NP25 in situ2005
- Author(s)
  Muto, Y., Okano, Y.
- Journal Title
  
  Current issues on multidisciplinary microscopy research and education (A.Mendez-Vilas(Ed.)) (Formatex Research Centre, Badajoz, Spain)
  
  Pages: 39-44
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570093
[Journal Article] Neuronal protein NP25 interacts with F-actin.2004
- Author(s)
  Mori K, Muto Y, Kokuzawa J, Yoshioka T, Yoshimura S, Iwama T, Okano Y, Sakai N.
- Journal Title
  
  Neurosci Res 48
  
  Pages: 439-446
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570093
[Journal Article] Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells.2004
- Author(s)
  Sasai K, Katayama H, Stenoien DL, Fujii S, Honda R, Kimura M, Okano Y, Tatsuka M, Suzuki F, Nigg EA, Earnshaw WC, Brinkley WR, Sen Subrata
- Journal Title
  
  Cell Motil Cytoskelet 59
  
  Pages: 249-263
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570093
[Journal Article] The RING finger protein, RNF8, interacts with retinoid X receptor α and enhances its transcription-stimulating activity.2004
- Author(s)
  Takano Y, Adachi S, Okuno M, Muto Y, Yoshioka T, Matsushima-Nishiwaki R, Tsurumi H, Ito K, Friedman.S.L, Moriwaki H, Kojima S, Okano Y
- Journal Title
  
  J Biol Chem 279
  
  Pages: 18926-18934
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570093
[Journal Article] Cell cycle-dependent regulation of the human aurora B promoter.2004
- Author(s)
  Kimura M, Uchida C, Takano Y, Kitagawa M, Okano Y.
- Journal Title
  
  Biochem Biophys Res Commun 316
  
  Pages: 930-936
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570093

1. KIMURA Masashi (40260575)

# of Collaborated Projects: 12 results

# of Collaborated Products: 6 results
2. YOSHIOKA Takashi (20311699)

# of Collaborated Projects: 7 results

# of Collaborated Products: 3 results
3. NOZAWA Yoshinori (10021362)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. BANNO Yoshiko (50116852)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. MORIWAKI Hisataka (50174470)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
6. MUTO Yoshinori (80190859)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
7. KANAHO Yasunori (00214437)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 中島茂 (60188935)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. TANAKA Takuji (40126743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KOJIMA Souichi (10202061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. NISHIGUCHI Shuhei (10192246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SHIMIZU Masahito (90402198)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. KOHNO Michiaki (00027335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NOMOTO Hiroshi (80164747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. FUJIWARA Hisayoshi (80115930)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TAKEMURA Genzo (40283311)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. SHIRATORI Yoshimune (20313877)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. SHIDOJI Yoshihiro (00111518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. NAGAO Seiji (30183528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. EGAWA Kouji (00012724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 福井泰久 (00181248)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 遠藤剛 (30194038)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 浜口道成 (90135351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 稲垣昌樹 (30183007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 貝淵弘三 (00169377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 鷲見典子 (60273140)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 野田伸司 (70303500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 永田浩一 (50252143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 郭泰彦 (90242718)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 坂井昇 (10021487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 西村康明 (60198512)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 原田実根 (00019621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 奥野正隆 (10204140)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 末岡尚子 (20321846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 山口研成 (10321845)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. ERA Seiichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OKANO Yukio 岡野 幸雄

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Interactions of the retinoid X receptor with a RING protein and its effects on ubiquitylation and transcriptionPrincipal Investigator

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ヒトAuroraおよび細胞分裂関連蛋白質の機能解析Principal Investigator

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AIKキナーゼファミリーの癌細胞における発現と機能解析Principal Investigator

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Molecular mechanism of steroid receptor ubiquitinationPrincipal Investigator

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AIKキナーゼファミリーの癌細胞における発現と機能Principal Investigator

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中心体キナーゼAikファミリーのがん細胞における発現Principal Investigator

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Project Period (FY)

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Research Institution

ヒト中心体キナーゼAikの細胞分裂における役割Principal Investigator

OKANO Yukio 岡野幸雄