OKANO Yukio 岡野幸雄

Researcher Number	10177066
Other IDs
Affiliation (based on the past Project Information) *help	2012: 岐阜大学, 医学系研究科, 教授 2009: 岐阜大学, 医学系研究科, 教授 2007 – 2009: 岐阜大学, 大学院・医学系研究科, 教授 2006: 岐阜大学, 大学院医学系研究科, 教授 2005: Gifu University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 … More
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Biological Sciences / General medical chemistry / Structural biochemistry Except Principal Investigator 代謝生物化学 / Biological Sciences / Cerebral neurosurgery / Cell biology / Pathological medical chemistry / Functional biochemistry / Circulatory organs internal medicine / General medical chemistry / Gastroenterology
Keywords	Principal Investigator dominant negative / centrosome / cell cycle / chromosome mapping / breast cancer / RING-finger / ipl-related kinase) / RNF8 / FRET / Cキナーゼ … More Except Principal Investigator ガングリオシド / 表皮細胞 / 分化誘導 / apoptosis / 化学予防 / レチノイド / GQ1b / シグナル伝達 / 核内受容体 / ホスホリパーゼC / ホスホリパ-ゼC / GTP結合蛋白質 / アポトーシス / Aurora / centrosome / histone H3 / phosphorylation / NEK / cell division / GQlb / トランスグルタミナーゼ / 14-3-3protein / PC-12cell / C6cell / hypoxia / serum deprivation / H_2O_2 / PC12 / H202 / 核受容体 / 発癌 / レチノイ / レチノイドレセプター / リン酸化 / FRET / 蛍光共鳴エネルギー移動 / 3次元立体像 / 遺伝子導入 / NP25 / GFP / 蛍光顕微鏡 / 分子標的 / 肝臓癌 / 肺発癌予防 / 核内受容体修飾異常 / リン酸化・非リン酸化RXR / 非環式レチノイド / 肝発癌予防 / がん / オーロラキナーゼ / 細胞分裂 / 細胞死 / 転写制御 / 血小板 / 情報伝達 / Gタンパク質 / 情報変換酵素 / 分子多様性 / Human Platelets / Phosphatidylinositol-phospholipase C / GTP-binding protein / Signaltransduction / 細胞増殖因子 / 百日咳毒素感受性G蛋白質 / Cキナ-ゼ / 受容体チロシンキナ-ゼ / ホスフォリパ-ゼC / PI3キナ-ゼ / G蛋白質活性化因子 / p21^<ras>ーGTPア-ゼ活性化蛋白質 / Peptide growth factor / Pertussis toxin-sensitive GTP-binding protein / Protein kinase C / Receptor tyrosine kinase / Phospolipase C / PI3-kinase / GTPase-activating protein / ヒト血小板 / G-蛋白質βγ / Human platelets / Phospholipase C / G protein betagamma / ラット頚動脈 / バルーン障害モデル / bax mRNA / 遺伝子治療 / 増殖能 / mouth muscle cells / TUNEL / electron microscopy / DNA ladder / Bax mRNA / intimal hyperplasia / restenosis / smooth muscle cells / cell devision / phosphorvlation / Aurora(AIK) / dominant negative / cell cycle / bladder cancer / colorectal cancer / 肝癌 / クローン除去 / ユビキチン化 / インターフェロン / RETINOID / HEPATOCELLULAR CARCINOMA / CANCER CHEMOPREVENTION / CLONAL DELETION / NUCLEAR RECEPTOR / APOPTOSIS / UBIQUITINATION / INTERFERON / テトラヒメナ / 脂肪酸不飽和化酵素 / サザンブロッティング / 膜流動性 / 低温シフト / DNA / cDNAクローニング / 環境適応機構 / 生体膜脂質 / 遺伝的解析 / 膜物性修飾 / membrane fluidity / low-temperature-shift / fatty acid desaturase Less

Elucidation of the function of Aurora kinases in mitosis and itsdysregulation in cancer
- Principal Investigator
  
  KIMURA Masashi
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Gifu University
Strategy for the chemoprevention of hepatocellular carcinoma by targeting phosphorylated RXRa
- Principal Investigator
  
  MORIWAKI Hisataka
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
Interactions of the retinoid X receptor with a RING protein and its effects on ubiquitylation and transcriptionPrincipal Investigator
- Principal Investigator
  
  OKANO Yukio
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Gifu University
ヒトAuroraおよび細胞分裂関連蛋白質の機能解析Principal Investigator
- Principal Investigator
  
  岡野幸雄
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
3次元蛍光共鳴エネルギー移動法による細胞内タンパク質間相互作用の解析
- Principal Investigator
  
  武藤吉徳
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Gifu University
AIKキナーゼファミリーの癌細胞における発現と機能解析Principal Investigator
- Principal Investigator
  
  岡野幸雄
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
核受容体蛋白を標的分子としたがん化学予防の研究
- Principal Investigator
  
  MORIWAKI Hisataka
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
Molecular mechanism of steroid receptor ubiquitinationPrincipal Investigator
- Principal Investigator
  
  OKANO Yukio
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Gifu University
AIKキナーゼファミリーの癌細胞における発現と機能Principal Investigator
- Principal Investigator
  
  岡野幸雄
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
Expression of AIK family in normal and cancer tissues
- Principal Investigator
  
  YOSHIOKA Takashi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Gifu University
MODIFICATION OF GROWTH AND APOPTOSIS BY UBIQUITINATION IN HEPATOMA CELL
- Principal Investigator
  
  SHIRATORI Yoshimune
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  GIFU UNIVERSITY
中心体キナーゼAikファミリーのがん細胞における発現Principal Investigator
- Principal Investigator
  
  岡野幸雄
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Gifu University
脳虚血時における細胞死シグナル伝達機構の調節に関する検討-シグナル調節蛋白(14-3-蛋白質)の役割
- Principal Investigator
  
  野田伸司
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Gifu University
Gene therapy against restenosis after balloom injury using apoptosis inducer, bax
- Principal Investigator
  
  FUJIWARA Hisayoshi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gifu University
ヒト中心体キナーゼAikの細胞分裂における役割Principal Investigator
- Principal Investigator
  
  岡野幸雄
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Gifu University
Functional analysis of a novel human kinase, Aik, involved in chromosome segregation.Principal Investigator
- Principal Investigator
  
  OKANO Yukio
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Gifu University
新規ヒトユビキチン結合酵素遺伝子の単離と細胞機能における役割の解析Principal Investigator
- Principal Investigator
  
  岡野幸雄
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Gifu University
細胞増殖・癌化のシグナル伝達とリン脂質代謝Principal Investigator
- Principal Investigator
  
  岡野幸雄
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Gifu University
Analysis of molecular mechanisms for suppression of Thy-1 expression in ras-transformed cells.Principal Investigator
- Principal Investigator
  
  OKANO Yukio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Gifu University
Control mechanism of phospholipase C activity in human platelets
- Principal Investigator
  
  BANNO Yoshiko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  GIFU UNIVERSITY
ガングリオシドGQ1bによる表皮細胞の分化誘導機構
- Principal Investigator
  
  野沢義則
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Gifu University
ガングリオシドGQlbによる表皮細胞の分化誘導機構
- Principal Investigator
  
  野沢義則
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Gifu University
Activation regulatory mechanisms of signal-transducing phospholipases in differentiated megakaryoblastic leukemia cells.Principal Investigator
- Principal Investigator
  
  OKANO Yukio
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Gifu University
ガングリオシドGQ1bによる表皮細胞の分化誘導機構
- Principal Investigator
  
  NOZAWA Yoshinori
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Gifu University
Interaction of multiple phospholipase C and GTP-binding proteins in platelet signal transduction
- Principal Investigator
  
  NOZAWA Yoshinori
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  代謝生物化学
- Research Institution
  Gifu University
Regulation of mitogenic signaling pathways which involve the function of GTP-binding protein-Possible involvement of protein tyrosine phosphorylation.
- Principal Investigator
  
  KOHNO Michiaki
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  代謝生物化学
- Research Institution
  Gifu Pharmaceutical University
Adaptation mechanism of membrane lipids and its genetic control
- Principal Investigator
  
  NOZAWA Yoshinori
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  代謝生物化学
- Research Institution
  Gifu University

All 2013 2012 2011 2009 2007 2006 2005 2004

All Journal Article

[Journal Article] Identification of a Rho family specific guanine nucleotide exchange factor, FLJ00018, as a novel actin-binding protein.2013
- Author(s)
  Sato, K., Handa, H., Kimura, M., Okano,Y., Nagaoka, H., Nagase, T., Sugiyama,T., Kitade, Y., and Ueda, H.
- Journal Title
  
  Cell Signal
  
  Volume: 25 Pages: 41-49
- DOI
  10.1016/j.cellsig.2012.09.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590331, KAKENHI-PROJECT-23590073, KAKENHI-PROJECT-23659151, KAKENHI-PUBLICLY-23118513
[Journal Article] Mitotic catastrophe and cell death induced by depletion of centrosomal proteins2013
- Author(s)
  Kimura, M., Yoshioka, T., Saio, M.,Banno, Y., Nagaoka, H., and Okano, Y
- Journal Title
  
  Cell Death Dis
  
  Volume: 4
- DOI
  10.1038/cddis.2013.108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590331, KAKENHI-PROJECT-23659151
[Journal Article] Growth suppression and mitotic defect inducedby JNJ-7706621, an inhibitor ofcyclin-dependent kinases and aurorakinases2012
- Author(s)
  Matsuhashi, A., Ohno, T., Kimura, M.,Hara, A., Saio, M., Nagano, A., Kawai,G., Saitou, M., Takigami, I., Yamada, K.,Okano, Y., and Shimizu, K
- Journal Title
  
  Curr. Cancer. Drug. Targets.
  
  Volume: 12 Pages: 625-639
- URL
  http://www.eurekaselect.com/98883/article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590331
[Journal Article] Plk1 is negatively regulated by RNF82011
- Author(s)
  Yoshioka, T., Kimura, M., Saio, M., Era,S., and Okano, Y
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 410 Pages: 57-6
- DOI
  10.1016/j.bbrc.2011.05.104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590331, KAKENHI-PROJECT-22590203
[Journal Article] Effects ofAZD1152, a selective Aurora B kinaseinhibitor, on Burkitt's and Hodgkin's lymphomas2011
- Author(s)
  Mori, N., Ishikawa, C., Senba, M.,Kimura, M., and Okano, Y.
- Journal Title
  
  Biochem. Pharmacol.
  
  Volume: 81 Pages: 1106-1115
- DOI
  10.1016/j.bcp.2011.02.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590331
[Journal Article] Aberrantpromoter hypermethylation of the CHFRgene in oral squamous cell carcinomas.2009
- Author(s)
  Baba, S., Hara, A., Kato, K., Long, N.K.,Hatano, Y., Kimura, M., Okano, Y.,Yamada, Y., and Shibata, T
- Journal Title
  
  Oncol. Rep.
  
  Volume: 22 Pages: 1173-1179
- URL
  http://www.spandidos-publications.com/or/22/5/1173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590331
[Journal Article] Phosphorylated retinoid X receptor alpha loses its heterodimeric activity with retinoic acid receptor beta.2007
- Author(s)
  Yoshimura K, Shimizu M, Kojima S, Okano Y, Moriwaki H, (他5名)
- Journal Title
  
  Cancer Sci 98
  
  Pages: 1868-1874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015016
[Journal Article] Structural and functional characterization of NP25, a single CH domain protein.2006
- Author(s)
  Kuwata H, Yoshioka T, Muto Y, Kuwata K, Okano Y.
- Journal Title
  
  Acta Sch Med Univ Gifu 54
  
  Pages: 1-7
- NAID
  110004470565
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570093
[Journal Article] The RING finger peotein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation.2006
- Author(s)
  Plans V, Scheper J, Soler M, Loukili N, Okano Y, Thomson TM.
- Journal Title
  
  J Cell Biochem 97
  
  Pages: 572-582
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570093
[Journal Article] Itnmuno-FRET microscopy of the actin-binding protein NP25 in situ2005
- Author(s)
  Muto, Y., Okano, Y.
- Journal Title
  
  Current issues on multidisciplinary microscopy research and education (A.Mendez-Vilas(Ed.)) (Formatex Research Centre, Badajoz, Spain)
  
  Pages: 39-44
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570093
[Journal Article] Neuronal protein NP25 interacts with F-actin.2004
- Author(s)
  Mori K, Muto Y, Kokuzawa J, Yoshioka T, Yoshimura S, Iwama T, Okano Y, Sakai N.
- Journal Title
  
  Neurosci Res 48
  
  Pages: 439-446
- NAID
  10023898546
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570093
[Journal Article] Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells.2004
- Author(s)
  Sasai K, Katayama H, Stenoien DL, Fujii S, Honda R, Kimura M, Okano Y, Tatsuka M, Suzuki F, Nigg EA, Earnshaw WC, Brinkley WR, Sen Subrata
- Journal Title
  
  Cell Motil Cytoskelet 59
  
  Pages: 249-263
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570093
[Journal Article] The RING finger protein, RNF8, interacts with retinoid X receptor α and enhances its transcription-stimulating activity.2004
- Author(s)
  Takano Y, Adachi S, Okuno M, Muto Y, Yoshioka T, Matsushima-Nishiwaki R, Tsurumi H, Ito K, Friedman.S.L, Moriwaki H, Kojima S, Okano Y
- Journal Title
  
  J Biol Chem 279
  
  Pages: 18926-18934
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570093
[Journal Article] Cell cycle-dependent regulation of the human aurora B promoter.2004
- Author(s)
  Kimura M, Uchida C, Takano Y, Kitagawa M, Okano Y.
- Journal Title
  
  Biochem Biophys Res Commun 316
  
  Pages: 930-936
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570093

1. KIMURA Masashi (40260575)

# of Collaborated Projects: 12 results

# of Collaborated Products: 6 results
2. YOSHIOKA Takashi (20311699)

# of Collaborated Projects: 7 results

# of Collaborated Products: 3 results
3. NOZAWA Yoshinori (10021362)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. BANNO Yoshiko (50116852)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. MORIWAKI Hisataka (50174470)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
6. MUTO Yoshinori (80190859)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
7. KANAHO Yasunori (00214437)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 中島茂 (60188935)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. TANAKA Takuji (40126743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KOJIMA Souichi (10202061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. NISHIGUCHI Shuhei (10192246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SHIMIZU Masahito (90402198)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. KOHNO Michiaki (00027335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NOMOTO Hiroshi (80164747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. FUJIWARA Hisayoshi (80115930)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TAKEMURA Genzo (40283311)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. SHIRATORI Yoshimune (20313877)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. SHIDOJI Yoshihiro (00111518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. NAGAO Seiji (30183528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. EGAWA Kouji (00012724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 福井泰久 (00181248)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 遠藤剛 (30194038)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 浜口道成 (90135351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 稲垣昌樹 (30183007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 貝淵弘三 (00169377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 鷲見典子 (60273140)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 野田伸司 (70303500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 永田浩一 (50252143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 郭泰彦 (90242718)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 坂井昇 (10021487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 西村康明 (60198512)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 原田実根 (00019621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 奥野正隆 (10204140)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 末岡尚子 (20321846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 山口研成 (10321845)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. ERA Seiichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 上田浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 長岡仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

OKANO Yukio 岡野 幸雄

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Interactions of the retinoid X receptor with a RING protein and its effects on ubiquitylation and transcriptionPrincipal Investigator

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ヒトAuroraおよび細胞分裂関連蛋白質の機能解析Principal Investigator

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AIKキナーゼファミリーの癌細胞における発現と機能解析Principal Investigator

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Molecular mechanism of steroid receptor ubiquitinationPrincipal Investigator

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AIKキナーゼファミリーの癌細胞における発現と機能Principal Investigator

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中心体キナーゼAikファミリーのがん細胞における発現Principal Investigator

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ヒト中心体キナーゼAikの細胞分裂における役割Principal Investigator

OKANO Yukio 岡野幸雄