KOHNO Michiaki 河野通明

Researcher Number	00027335
Other IDs
Affiliation (based on the past Project Information) *help	2012: 京都大学, 薬学研究科(研究院), 研究員 2011 – 2012: 京都大学, 薬学研究科, 研究員 2007 – 2010: Nagasaki University, 大学院・医歯薬学総合研究科, 教授 2005 – 2006: 長崎大学, 大学院医歯薬学総合研究科, 教授 2002 – 2005: 長崎大学, 大学院・医歯薬学総合研究科, 教授 … More
Review Section/Research Field	Principal Investigator Biological pharmacy / Biological Sciences / Functional biochemistry / Clinical oncology / 代謝生物化学 / 医薬分子機能学 / Biological pharmacy Except Principal Investigator 植物生理学 / Neurology / Dermatology
Keywords	Principal Investigator 細胞がん化 / MAPキナーゼ / MEK阻害剤 / ERK-MAPキナーゼ / アポトーシス / がん化学療法 / 神経成長因子 / 骨形成因子 / p38MAPキナーゼ / MAPキナーゼ・キナーゼ … More Except Principal Investigator 増殖因子 / FGF / EGF / TGF / トランスフォーメーション / Cキナーゼ / TGFβ / シグナル伝達 / TNF / チロシン燐酸化 / チロシンキナ-ゼ / c-met / MAPキナーゼ / サイトカイン / 癌と間質との相互作用 / HGF / リポソーム / bFGF / オートクリン制御 / レセプタ-系 / EGFレセプタ- / TGFα / 増殖因子系遺伝子の転写因子 / 癌遺伝子 / GCF / 転写因子 / cーmet / cripto / PDーECGF / インスリン受容体 / 肝細胞増殖因子 / カルホスチンC / インスリンレセプター / K-sam / FGFレセプター / チロシンキナーゼ受容体 / 細胞接着分子 / ERMファミリー / 癌抑制遺伝子 / 増殖因子レセプター / p115 / インターフェロン / アポトーシス / Hrs / IGF / レセプター / フィブロネクチン / ビトロネクチン / 細胞接着因子 / ヘパリン / インスリン / IGFーI / 受容体 / myc / ras / src / チロシンリン酸化 / PI代謝回転 / DNA合成促進因子 / インスリン受容体キナーゼ / V型コラーゲン / 増殖促進シグナル / シソ科 / タチジャコウソウ / モノテルペノイド / 腺鱗 / 腺毛 / フィトクロム / 光情報伝達 / リン酸化反応 / タイム / モノテルペン / Labiatae / Thymus vulgaris L. / Monoterpenoid / Glandular trichomes / Phytochrome / Phosphorylation / signal transduction / 老人痴呆症 / 酵素免疫測定法 / 早期診断法 / 神経栄養因子 / GFGF / NT-3 / NGF / 抗体 / 酵素免疫側定法(EIA) / 最少検出量 / 再現性 / 特異性 / neurotrophin-3 (NT-3) / enzyme immunoassay (EIA) / diagnosis / nerve growth factor (NGF) / neurotrophic factor (NTF) / serum / cerebrospinal fluid / periphral tissue / 創傷 / 創傷治癒 / TNF-α / 神経再生 / 腫瘍壊死因子 / 神経成長因子 / 線維芽細胞 / skin ulser / wound healing / TNF-alpha / nerve regeneration Less

Targeting the ERK-MAP kinase pathway in cancer therapyPrincipal Investigator
- Principal Investigator
  
  KOHNO Michiaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Clinical oncology
- Research Institution
  Kyoto University
  Nagasaki University
Targeting the ERK-MAP kinase pathway in cancer therapyPrincipal Investigator
- Principal Investigator
  
  KOHNO Michiaki
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
Role of MAP kinase cascades in the regulation of diverse cellular functionsPrincipal Investigator
- Principal Investigator
  
  KOHNO Michiaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagasaki University
チューブリン重合阻害剤の抗腫瘍効果発現機構に対する再検討Principal Investigator
- Principal Investigator
  
  河野通明
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagasaki University
Role of MAP Kinase Cascade in the Regulation of Diverse Cellular FunctionsPrincipal Investigator
- Principal Investigator
  
  KOHNO Michiaki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagasaki University
MAPキナーゼカスケードを構成するシグナル分子を標的とした細胞増殖阻害物質の探索Principal Investigator
- Principal Investigator
  
  河野通明
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
チューブリン重合阻害剤の抗腫瘍効果発現機構に対する再検討Principal Investigator
- Principal Investigator
  
  河野通明
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagasaki University
MAPキナーゼカスケードを構成するシグナル分子を標的とした細胞増殖阻害物質の探索Principal Investigator
- Principal Investigator
  
  河野通明
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
MAPキナーゼカスケードを構成するシグナル分_2を標的とした細胞増殖阻害物質の検索Principal Investigator
- Principal Investigator
  
  河野通明
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Nagasaki University
骨形成因子が神経栄養因子活性を持つことの生物学的意義の解明Principal Investigator
- Principal Investigator
  
  河野通明
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagasaki University
Development of specific inhibitors against MAP kinase pathwaysPrincipal Investigator
- Principal Investigator
  
  KOHNO Michiaki
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagasaki University
MAPキナーゼカスケードを構成するシグナル分子を標的とした細胞増殖阻害物質の探索Principal Investigator
- Principal Investigator
  
  河野通明
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Nagasaki University
Role of MAP Kinase Cascade in the Regulation of Diverse Cellular Fuctions.Principal Investigator
- Principal Investigator
  
  KOHNO Michiaki
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagasaki University
ヒトがん細胞におけるMAPキナーゼカスケードの異常-細胞がん化との相関Principal Investigator
- Principal Investigator
  
  河野通明
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagasaki University
MAPキナーゼカスケードを構成するシグナル分子を標的とした細胞増殖阻害物質の検索Principal Investigator
- Principal Investigator
  
  河野通明
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Gifu Pharmaceutical University
Role of the ERK MAP Kinase Cascade in the Regulation of Cell Proliferation and Differentiation.Principal Investigator
- Principal Investigator
  
  KOHNO Michiaki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagasaki University
  Gifu Pharmaceutical University
細胞増殖因子からみた癌細胞と間質細胞との相互作用-その分子機構-
- Principal Investigator
  
  田原榮一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hiroshima University
MAPキナーゼの恒常的活性化がヒトがん発生の直接的な原因となる可能性の検討Principal Investigator
- Principal Investigator
  
  河野通明
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Gifu Pharmaceutical University
創傷修復過程における末梢神経再生の分子機構-腫瘍壊死因子によるNGF遺伝子の発現制御Principal Investigator
- Principal Investigator
  
  河野通明
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Gifu Pharmaceutical University
Development of anti-skin ulcer drug based on the new concept -Application of the stimulatory effect of TNF-alpha on the production of NGF in fibroblastsPrincipal Investigator
- Principal Investigator
  
  KOHNO Michiaki
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Gifu Pharmaceutical University
細胞増殖因子からみた癌細胞と間質細胞との相互作用 -その分子機構-
- Principal Investigator
  
  田原榮一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hiroshima University
Development of anti-skin ulcer drug based on the new concept-application of the effect of TNF-alpha on regeneration of peripheral nerve.
- Principal Investigator
  
  TAKIGAWA Masahiro
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Hamamatsu University School of Medicine
細胞増殖因子からみた癌細胞と間質細胞との相互作用 -その分子機構-
- Principal Investigator
  
  田原榮一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hiroshima University
細胞増殖因子作用における41-kDa、43-kDa・MAPキナーゼ活性化の役割Principal Investigator
- Principal Investigator
  
  河野通明
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Gifu Pharmaceutical University
Development of the Enzyme Immunoassay System for the Substances Related to the Pathogenesis of Alzheimer's Disease
- Principal Investigator
  
  HAYASHI Kyozo
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Gifu Pharmaceutical University
癌の増殖における増殖因子の相互作用とその分子機構
- Principal Investigator
  
  田原榮一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hiroshima University
癌の増殖における増殖因子の相互作用とその分子機構
- Principal Investigator
  
  田原榮一
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hiroshima University
細胞増殖因子作用における41K,43K蛋白質チロシンリン酸化反応促進の役割ー41K,43K蛋白質のcDNAクロ-ニングPrincipal Investigator
- Principal Investigator
  
  河野通明
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Gifu Pharmaceutical University
癌の増殖における増殖因子の相互作用とその分子機構
- Principal Investigator
  
  田原榮一
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hiroshima University
Phytochrome-mediated formation of terpenoids and glandular trichomes, and rapid tyrosine phosphorylation of a 25-kDa protein in thyme seedlings
- Principal Investigator
  
  TANAKA Shigeo
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  植物生理学
- Research Institution
  Kyoto University
Regulation of mitogenic signaling pathways which involve the function of GTP-binding protein-Possible involvement of protein tyrosine phosphorylation.Principal Investigator
- Principal Investigator
  
  KOHNO Michiaki
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  代謝生物化学
- Research Institution
  Gifu Pharmaceutical University
細胞増殖因子作用の分子機構とトランスフォーメーション
- Principal Investigator
  
  清水信義
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Keio University
細胞増殖因子作用の分子機構とトランスフォーメーション
- Principal Investigator
  
  清水信義
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Keio University
誘発型発癌遺伝子および増殖因子による細胞のGo/Gi期からS期への移行機構の比較解析Principal Investigator
- Principal Investigator
  
  河野通明
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Gifu Pharmaceutical University
細胞増殖因子作用の分子機構とトランスフォーメーション
- Principal Investigator
  
  清水信義
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Keio University
細胞増殖因子の作用機構とトランスフォーメーションの研究
- Principal Investigator
  
  清水信義
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Keio University

All 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 Other

All Journal Article Presentation Book

[Book] 細胞死実験プロトコール(編集:刀祢重信、小路武彦)(分担執筆)2011
- Author(s)
  坂元利影、河野通明
- Total Pages
  224
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-22300340
[Book] 細胞死実験プロトコール2011
- Author(s)
  坂元利彰、河野通明
- Total Pages
  224
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-22300340
[Book] 細胞内シグナル伝達経路の選択的遮断を基盤としたがん治療戦略2008
- Author(s)
  尾崎恵一、谷村進、河野通明
- Publisher
  ファルマシア
- Data Source
  KAKENHI-PROJECT-17016056
[Book] シグナル伝達- 1. MAPキナーゼ経路, がんの分子標的治療(鶴雄隆編)2008
- Author(s)
  河野通明
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-17016056
[Book] がんの分子標的治療(鶴尾隆編集)2008
- Author(s)
  河野通明(分担執筆)
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-17016056
[Book] シグナル伝達系, 新臨床腫瘍学(日本臨床腫瘍学会編)2006
- Author(s)
  河野通明
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-17016056
[Journal Article] Blockade of the ERK pathway enhances the therapeutic efficacy of the histone deacetylase inhibitor MS-275 in human tumor xenograft models2013
- Author(s)
  Sakamoto, T., Ozaki, K., Fujio, K., Kajikawa, S., Uesato, S., Watanabe, K., Tanimura, S., Koji, T. & Kohno, M
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 433 Pages: 456-462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300340
[Journal Article] Inhibition of the p38 MAPK pathway ameliorates renal fibrosis in an NPHP2 mouse model2012
- Author(s)
  Sugiyama, N., Kohno, M. & Yokoyama, T.
- Journal Title
  
  Nephrol. Dial. Transplant
  
  Volume: 27 Pages: 1351-1358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300340
[Journal Article] Up-regulation of pro-apoptotic protein Bim and down-regulation of anti-apoptotic protein Mcl-1 cooperatively mediate enhanced tumor cell death induced by the combination of ERK kinase (MEK) inhibitor and microtubule inhibitor.2012
- Author(s)
  Kawabata, T. Tanimura, S., Asai, K., Kawasaki, R., Matsumaru, Y. & Kohno, M.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287 Pages: 10289-10300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300340
[Journal Article] Up-regulation of pro-apoptotic protein Bim and down-regulation of anti-apoptotic protein Mcl-1 cooperatively mediate enhanced tumor cell death induced by the combination of ERK kinase (MEK) inhibitor and microtubule inhibitor2012
- Author(s)
  Kawabata, T., Kohno, M., et al
- Journal Title
  
  J. Biol. Chem
  
  Volume: 287 Pages: 10289-10300
- DOI
  10.1074/jbc.m111.319426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300340, KAKENHI-PROJECT-23790090
[Journal Article] Targeting the Extracellular Signal-Regulated Kinase Pathway in Cancer Therapy2011
- Author(s)
  Kohno M., Tanimura S., Ozaki K.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 34 Issue: 12 Pages: 1781-1784
- DOI
  10.1248/bpb.34.1781
- NAID
  130001872595
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590166, KAKENHI-PROJECT-22300340
[Journal Article] Targeting the extracellular signal-regulated kinase pathway in cancer therapy.2011
- Author(s)
  Kohno, M., Tanimura, S. & Ozaki, K.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 34 Pages: 1781-1784
- NAID
  130001872595
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300340
[Journal Article] SH3P2 is a negative regulator of cell motility whose function is inhibited by RSK-mediated phosphorylation.2011
- Author(s)
  Tanimura, S., Hashizume, J., Kurosaki, Y., Sei,K., Gotoh, A., Ohtake, R., Kawano, M., Watanabe, K. & Kohno. M.
- Journal Title
  
  Genes Cells
  
  Volume: 16 Pages: 514-526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300340
[Journal Article] SH3P2 is a negative regulator of cell motility whose function is inhibited by RSK-mediated phosphorylation2011
- Author(s)
  Tanimura, S., Kohno, M., et al
- Journal Title
  
  Genes Cells
  
  Volume: 16 Pages: 514-526
- DOI
  10.1111/j.1365-2443.2011.01503.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300340
[Journal Article] Peumusolide A, unprecedented NES non- antagonistic inhibitor for nuclear export of MEK.2010
- Author(s)
  Tamura, S., Hattori, Y., Kaneko, M., Shimizu, N., Tanimura, S., Kohno, M. & Murakami, N.
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 51 Pages: 1678-1681
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300340
[Journal Article] Blockade of the extracellularsignal-regulated kinase pathway enhances the therapeutic efficacy of microtubule destabilizing agents in human tumor xenograft models.2010
- Author(s)
  Watanabe, K., Tanimura, S., Uchiyama, A., Sakamoto, T., Kawabata, T., Ozaki, K. & Kohno, M.
- Journal Title
  
  Clin. Cancer Res
  
  Volume: 16 Pages: 1170-1178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300340
[Journal Article] Blockade of the ERK or PI3K-Akt signaling pathway enhances the cytotoxicity of histone deacetylase inhibitors in tumor cells resistant to gefitinib or imatinib.2010
- Author(s)
  Ozaki, K., Kosugi, M., Baba, N., Fujio, K., Sakamoto, T., Kimura, S., Tanimura, S., Kohno, M.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 391
  
  Pages: 1610-1615
- NAID
  120001814943
- Data Source
  KAKENHI-PROJECT-17016056
[Journal Article] Blockade of the extracellular signal-regulated kinase pathway enhances the therapeutic efficacy of microtubuledestabilizing agents in human tumor xenograft models.2010
- Author(s)
  Watanabe, K., Tanimura, S., Uchiyama, A., Sakamoto, T., Kawabata, T., Ozaki, K., Kohno, M.
- Journal Title
  
  Clin. Cancer Res. 16
  
  Pages: 1170-1178
- Data Source
  KAKENHI-PROJECT-17016056
[Journal Article] unprecedented NES non-antagonistic inhibitor for nuclear export of MEK.2010
- Author(s)
  Tamura, S., Hattori, Y., Kaneko, M., Shimizu, N., Tanimura, S., Kohno, M., Murakami, N. Peumusolide A
- Journal Title
  
  Tetrahedron Lett. 51
  
  Pages: 1678-1681
- Data Source
  KAKENHI-PROJECT-17016056
[Journal Article] Blockade of constitutively activated ERK signaling enhances cytotoxicity of microtubule-destabilizing agents in tumor cells.2009
- Author(s)
  Tanimura, S., Uchiyama, A., Watanabe, K., Yasunaga, M., Inada, Y., Kawabata, T., Iwashita, K., Noda, S., Ozaki, K., Kohno, M.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 378
  
  Pages: 650-655
- NAID
  120001629877
- Data Source
  KAKENHI-PROJECT-17016056
[Journal Article] GEF-H1 mediates tumor necrosis factor-α-induced Rho activation and myosin phosphorylation: Role in the regulation of tubular paracellular permeability.2009
- Author(s)
  Kakiashvili, E., Speight, P., Waheed, F., Seth, R., Lodyga, M., Tanimura, S., Kohno, M., Rotstein, O.D., Kapus, A., Szaszi, K.
- Journal Title
  
  J. Biol. Chem. 284
  
  Pages: 11454-11466
- Data Source
  KAKENHI-PROJECT-17016056
[Journal Article] Histone deacetylase inhibitors enhance the chemosensitivity of tumor cells with cross-resistance to a wide range of DNA-damaging drugs.2008
- Author(s)
  Ozaki, K., Kishikawa, F., Tanaka, M., Sakamoto, T., Tanimura, S, Kohno, M.
- Journal Title
  
  Cancer Sci. 99
  
  Pages: 376-384
- NAID
  10024002722
- Data Source
  KAKENHI-PROJECT-17016056
[Journal Article] ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA.2008
- Author(s)
  Fujishiro, S., Tanimura, S., Mure, S., Kashimoto, Y., Watanabe, K, Kohno, M.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 368
  
  Pages: 162-167
- Data Source
  KAKENHI-PROJECT-17016056
[Journal Article] Blockade of the phosphatidylinositol 3-kinase-Akt signaling pathway enhances induction of apoptosis by microtubule-destabilizing agents in tumor cells in which the pathway is constitutively activated.2007
- Author(s)
  Fujiwara, Y., Hosokawa, Y., Watanabe, K., Tanimura, S., Ozaki, K., Kohno, M.
- Journal Title
  
  Mol.Cancer Ther. 6
  
  Pages: 1133-1142
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390020
[Journal Article] Enantioselective total synthesis of (+)- Ottelione A, (-)-Ottelione B, (+)-3-epi- Otterlione A and preliminary evaluation of antitumor activity.2007
- Author(s)
  Araki, H., Inoue, M., Suzuki, T., Yamori, T., Kohno, M., Watanabe, K., Abe, H., Katoh, T.
- Journal Title
  
  Chem. Eur. J. 13
  
  Pages: 9866-9881
- Data Source
  KAKENHI-PROJECT-17016056
[Journal Article] Requirement of ERK MAP kinase in mouse preimplantation development.2007
- Author(s)
  Maekawa, M., Yamamoto, T., Kohno, M., Takeichi, M., Nishida, E.
- Journal Title
  
  Development 134
  
  Pages: 2751-2759
- Data Source
  KAKENHI-PROJECT-17016056
[Journal Article] Blockade of the phosphatidylinositol 3-kinase-Akt signaling pathway enhances induction of apoptosis by microtubuledestabilizing agents in tumor cells in which the pathway is constitutively activated.2007
- Author(s)
  Fujiwara, Y., Hosokawa, Y., Watanabe, K., Tanimura, S., Ozaki, K, Kohno, M.
- Journal Title
  
  Mol. Cancer Ther. 6
  
  Pages: 1133-1142
- Data Source
  KAKENHI-PROJECT-17016056
[Journal Article] Anticancer drugs up-regulate HspBP1 and thereby antagonize the prosurvival function of Hsp70 in tumor cells.2007
- Author(s)
  Tanimura, S., Hirano, A., Hashizume, J., Yasunaga, M., Kawabata, T., Ozaki, K, Kohno, M.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 35430-35439
- Data Source
  KAKENHI-PROJECT-17016056
[Journal Article] Targeting the ERK signaling pathway in Cancer Therapy2006
- Author(s)
  Kohno, M.
- Journal Title
  
  Ann. Medicine 38巻
  
  Pages: 200-211
- Data Source
  KAKENHI-PROJECT-17016056
[Journal Article] Targeting the ERK signaling pathway in Cancer Therapy2006
- Author(s)
  Kohno, M.
- Journal Title
  
  Ann.Medicine 38巻
  
  Pages: 200-211
- Data Source
  KAKENHI-PROJECT-17390020
[Journal Article] Targeting the ERK signaling pathway in Cancer Therapy (Invited Review).2006
- Author(s)
  Kohno, M., Pouyssegur, J.
- Journal Title
  
  Ann.Medicine 38
  
  Pages: 200-211
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390020
[Journal Article] Targeting the ERK signaling pathway in Cancer Therapy. Ann.2006
- Author(s)
  Kohno, M., Pouyssegur, J.
- Journal Title
  
  Medicine 38
  
  Pages: 200-211
- Data Source
  KAKENHI-PROJECT-17016056
[Journal Article] ERK inhibition slows disease progression in mice with polycystic kidney disease.2006
- Author(s)
  Omori, S., Hida, M., Fujita, H., Takahashi, H., Tanimura, S., Kohno, M., Awazu, M.
- Journal Title
  
  J.Am.Soc.Nephrol. 17
  
  Pages: 1604-1614
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390020
[Journal Article] Targeting the ERK signaling pathway in Cancer Therapy2006
- Author(s)
  Kohno, M.
- Journal Title
  
  Ann. Medicine 38巻
  
  Pages: 200-211
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390020
[Journal Article] Inhibition of the PI3 kinase/Akt pathway enhances doxorubicin-induced apoptotic cell death in tumor cells in a p53-dependent manner.2006
- Author(s)
  Fujiwara, Y., Kawada, K., Takano, D., Tanimura, S., Ozaki, K., Kohno, M.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 340
  
  Pages: 560-566
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390020
[Journal Article] Blockade of the ERK pathway markedly sensitizes tumor cells to HDAC inhibitor-induced cell death.2006
- Author(s)
  Ozaki, K., Minoda, A., Kishikawa, F., Kohno, M.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 339
  
  Pages: 1171-1177
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390020
[Journal Article] Blockade of the ERK pathway markedly sensitizes tumor cells to HDAC inhibitor-induced cell death.2006
- Author(s)
  Ozaki, K., Minoda, A., Kishikawa, F, Kohno, M.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 339
  
  Pages: 1171-1177
- Data Source
  KAKENHI-PROJECT-17016056
[Journal Article] Suppression of tumor cell invasiveness by hydrolysable tannins (plant polyphenols) via the inhibition of matrix metalloproteinase-2/-9 activity.2005
- Author(s)
  Tanimura, S., Kadomoto, R., Tanaka, T., Zhang, Y., Kouno, I., Kohno, M.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 330
  
  Pages: 1306-1313
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390020
[Journal Article] Efficient Suppression of Fibroblast Growth Factor-2-induced ERK Activation by the Cooperative Interaction among Mammalian Sprouty Isoforms.2005
- Author(s)
  Ozaki, K., Miyazaki, S., Tanimura, S, Kohno, M.
- Journal Title
  
  J. Cell Sci. 118
  
  Pages: 5861-5871
- Data Source
  KAKENHI-PROJECT-17016056
[Journal Article] Constitutive activation of the 41- and 43-kDa mitogen-activated protein (MAP) kinases in the progression of prostate cancer to an androgen-independent state.2005
- Author(s)
  Oka, H., Chatani, Y., Kohno, M., Kawakita, M., Ogawa, O.
- Journal Title
  
  Int.J.Urol. 12
  
  Pages: 899-905
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390020
[Journal Article] ERK-MAP kinase inhibitors in cancer therapy.2005
- Author(s)
  Kohno, M., Pouyssegur, J.
- Journal Title
  
  Annals Medicine (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370747
[Journal Article] Hetero-oligomerization of mammalian Sprouty1 and Sprouty4 efficiently suppresses fibroblast growth factor-2-induced ERK activation by preventing the association of Grb2-Sos1 complex with FRS2.2005
- Author(s)
  Ozaki, K., Miyazaki, S., Tanimura, S., Kohno, M.
- Journal Title
  
  Oncogene (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370747
[Journal Article] Suppression of tumor cell invasiveness by hydrolysable tannins (plant polyphenols) via the inhibition of matrix metalloproteinase-2/ -9 activity.2005
- Author(s)
  Tanimura, S., Kadomoto, R., Tanaka, T., Zhang, Y., Kouno, I, Kohno, M.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 330
  
  Pages: 1306-1313
- Data Source
  KAKENHI-PROJECT-17016056
[Journal Article] Suppression of tumor cell invasiveness by hydrolysable tannins (plant polyphenols) via the inhibition of matrix metalloproteinase-2/-9 activity.2005
- Author(s)
  Tanimura, S., Kadomoto, R., Tanaka, T., Zhang, Y., Kouno, I., Kohno, M.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 330
  
  Pages: 1306-1313
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370747
[Journal Article] Efficient Suppression of Fibroblast Growth Factor-2-induced ERK Activation by the Cooperative Interaction among Mammalian Sprouty Isoforms.2005
- Author(s)
  Ozaki, K., Miyazaki, S., Tanimura, S., Kohno, M.
- Journal Title
  
  J.Cell Sci. 118
  
  Pages: 5861-5871
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390020
[Journal Article] Synthesis and structure-activity relationships of thioflavone derivatives as specific inhibitors of the ERK-MAP kinase signaling pathway.2004
- Author(s)
  Kataoka, T., Watanabe, S., Mori, E., Kadomoto, R., Tanimura, S., Kohno, M.
- Journal Title
  
  Bioorg.Med.Chem. 12
  
  Pages: 2397-2407
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370747
[Journal Article] チューブリン阻害活性の検定2004
- Author(s)
  河野通明
- Journal Title
  
  癌と化学療法 31巻
  
  Pages: 501-506
- Data Source
  KAKENHI-PROJECT-13218101
[Journal Article] ERK-MAPキナーゼカスケードを標的とした癌治療2004
- Author(s)
  河野通明
- Journal Title
  
  現代医療 36巻
  
  Pages: 1401-1410
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370747
[Journal Article] ERK-MAPキナーゼカスケードを標的とした癌治療2004
- Author(s)
  河野通明
- Journal Title
  
  現代医療 36巻
  
  Pages: 1401-1410
- Data Source
  KAKENHI-PROJECT-13218101
[Journal Article] チューブリン阻害活性の検定2004
- Author(s)
  河野通明
- Journal Title
  
  癌と化学療法 31巻
  
  Pages: 501-506
- Data Source
  KAKENHI-PROJECT-14370747
[Journal Article] Pharmacological inhibitors of the ERK signaling pathway : Application as anticancer drugs.2003
- Author(s)
  Kohno, M., Pouyssegur, J.
- Journal Title
  
  Prog.Cell Cycle Res. 5
  
  Pages: 219-224
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370747
[Journal Article] Specific blockade of the ERK pathway inhibits the invasiveness of tumor cells : down-regulation of matrix metalloproteinase-3/-9/-14 and CD44.2003
- Author(s)
  Tanimura, S., Asato, K., Fujishiro, S., Kohno, M.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 304
  
  Pages: 801-806
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370747
[Journal Article] Pharmacological inhibitors of the ERK signaling pathway : Application as anticancer drugs.2003
- Author(s)
  Kohno, M.
- Journal Title
  
  Prog.Cell Cycle Res. 5巻
  
  Pages: 219-244
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370747
[Journal Article] Prolonged Nuclear Retention of Activated Extracellular Signal-Regulated Kinase1/2 is Required for Hepatocyte Growth Factor-induced Cell Motility.2002
- Author(s)
  Tanimura, S., Nomura, K., Ozaki, K., Tsujimoto, M., Kondo, T., Kohno, M.
- Journal Title
  
  J.Biol.Chem. 277
  
  Pages: 28256-28264
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370747
[Journal Article] Anticancer drugs up-regulate HspBP1 and thereby antagonize the prosurvival function of Hsp70 in tumor cells.
- Author(s)
  Tanimura, S., Hirano, A., Hashizume, J., Tasunaga, M., Kawabata, T., Ozaki, K., Kohno, M.
- Journal Title
  
  J.Biol.Chem. (under review)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390020
[Presentation] UNC45 によるMyosin1E の細胞内局在制御2012
- Author(s)
  平田弦也、谷村進、木原康孝、尾崎惠一、武田弘資、河野通明
- Organizer
  第29回日本薬学会九州支部大会
- Place of Presentation
  熊本県
- Year and Date
  2012-12-09
- Data Source
  KAKENHI-PROJECT-22300340
[Presentation] Myosin1E によるカベオラ形成制御と細胞運動2012
- Author(s)
  中原康子、谷村進、浜松絢子、尾崎惠一、武田弘資、河野通明
- Organizer
  第29回日本薬学会九州支部大会
- Place of Presentation
  熊本県
- Year and Date
  2012-12-09
- Data Source
  KAKENHI-PROJECT-22300340
[Presentation] Myosin1E の細胞運動亢進作用はUNC45-Hsp90 複合体による細胞内局在制御によって調節される2012
- Author(s)
  谷村進、平田弦也、大山要、中原康子、松丸由美、尾崎惠一、武田弘資、河野通明
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡県
- Year and Date
  2012-12-15
- Data Source
  KAKENHI-PROJECT-22300340
[Presentation] MEK and microtubule inhibitors together kill tumor cells through up-regulation of Bim and down-regulation of Mcl-12012
- Author(s)
  谷村進、河野通明
- Organizer
  第71回日本癌学会学術大会
- Place of Presentation
  北海道
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-22300340
[Presentation] Myosin1Eは糸状仮足の形成制御を介して細胞運動を促進する2011
- Author(s)
  谷村進、河野通明, 他
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-22300340
[Presentation] HC-toxinとPD184352の併用はBimの発現上昇を介してROSの蓄積と細胞死を相乗的に誘導する2011
- Author(s)
  尾崎恵一、河野通明, 他
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-22300340
[Presentation] Myosin 1E による細胞運動制御の分子メカニズム2011
- Author(s)
  森田和幹、平田弦也、中原康子、谷村進、河野通明
- Organizer
  第28回日本薬学会九州支部大会
- Place of Presentation
  福岡県
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-22300340
[Presentation] Myosin 1E enhances cell motility via the induction of filopodia formation: essential role of phosphorylation on Ser7362011
- Author(s)
  谷村進、橋詰淳哉、渡邉一石、河野通明
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  愛知県
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-22300340
[Presentation] MEK 阻害剤と微小管重合阻害剤の併用による細胞死誘導増強作用の分子機構2010
- Author(s)
  浅井廣平、川畑拓誠、内山綾、谷村進、河野通明
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎県
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-22300340
[Presentation] MEK阻害剤とHDAC阻害剤の併用による抗腫瘍効果増強-Xenograftでの検討-2010
- Author(s)
  坂元利彰、藤尾康祐、梶川修平、上里新一、渡邉一石、谷村進、尾崎恵一、河野通明
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪府
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-22300340
[Presentation] 新規細胞運動制御因子 SH3P2 は Myosin 1E と結合する2010
- Author(s)
  河野通宏、橋詰淳哉、森田和幹、金丸雄祐、谷村進、河野通明
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎県
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-22300340
[Presentation] 新規タンパク質 SH3P2 による細胞運動制御の分子機構2010
- Author(s)
  谷村進、大竹里佳、河野通宏、橋詰淳哉、後藤愛依子、黒崎由希子、瀬井香奈子、河野通明
- Organizer
  第83回日本生化学会大会
- Place of Presentation
  兵庫県
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22300340
[Presentation] Myosin 1E は invadopodia の形成を介してがん細胞の浸潤を調節する2010
- Author(s)
  谷村進、橋詰淳哉、後藤愛依子、河野通宏、大竹里佳、渡邉一石、河野通明
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪府
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-22300340
[Presentation] Myosin 1E による細胞運動制御の分子機構2010
- Author(s)
  大竹里佳、橋詰淳哉、中原康子、谷村進、河野通明
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎県
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-22300340
[Presentation] Blockade of the ERK pathway enhances the antitumor activity of microtubule-destabilizing agents in vitro and in vivo.2008
- Author(s)
  Watanabe, K., Tanimura, S., Yasunaga, M. Uchiyama, A, Kohno, M.
- Organizer
  AACR Annual Meeting 2008
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-17016056
[Presentation] ERK-MAPキナーゼ経路の選択的遮断を基盤としたがん化学療法の開発2007
- Author(s)
  河野通明
- Organizer
  第66回日本がん学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-17016056
[Presentation] Targeting the ERK signaling pathway in cancer therapy2007
- Author(s)
  河野通明、谷村進、尾崎惠一、渡邊一石
- Organizer
  第65回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17016056
[Presentation] Blockade of the PI3-kinase-Akt signaling pathway enhances induction of apoptosis by microtubule- destabilizing agents in tumor cells in which the pathway is constitutively activated.2007
- Author(s)
  Watanabe, K., Fujiwara, Y., Tanimura, S., Ozaki, K, Kohno, M.
- Organizer
  AACR Annual Meeting 2007
- Place of Presentation
  Los Angeles
- Data Source
  KAKENHI-PROJECT-17016056

1. 清水信義 (50162706)

# of Collaborated Projects: 9 results

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2. SATO Masahiro (00240945)

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32. 豊島秀男 (20197966)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 加藤勝 (50233820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 大工原恭 (40028733)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 喜多村直実 (80107424)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 竹家達雄 (60112330)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. NAGAOKA Akinobu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. NAKAZATO Hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KOHNO Michiaki 河野 通明

Research Projects

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Co-Researchers

Targeting the ERK-MAP kinase pathway in cancer therapyPrincipal Investigator

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Targeting the ERK-MAP kinase pathway in cancer therapyPrincipal Investigator

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Role of MAP kinase cascades in the regulation of diverse cellular functionsPrincipal Investigator

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チューブリン重合阻害剤の抗腫瘍効果発現機構に対する再検討Principal Investigator

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Role of MAP Kinase Cascade in the Regulation of Diverse Cellular FunctionsPrincipal Investigator

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MAPキナーゼカスケードを構成するシグナル分子を標的とした細胞増殖阻害物質の探索Principal Investigator

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チューブリン重合阻害剤の抗腫瘍効果発現機構に対する再検討Principal Investigator

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MAPキナーゼカスケードを構成するシグナル分子を標的とした細胞増殖阻害物質の探索Principal Investigator

Principal Investigator

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MAPキナーゼカスケードを構成するシグナル分_2を標的とした細胞増殖阻害物質の検索Principal Investigator

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骨形成因子が神経栄養因子活性を持つことの生物学的意義の解明Principal Investigator

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Development of specific inhibitors against MAP kinase pathwaysPrincipal Investigator

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MAPキナーゼカスケードを構成するシグナル分子を標的とした細胞増殖阻害物質の探索Principal Investigator

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Role of MAP Kinase Cascade in the Regulation of Diverse Cellular Fuctions.Principal Investigator

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KOHNO Michiaki 河野通明