OTAKA Akira 大高章

Researcher Number	20201973
Other IDs
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Affiliation (Current)	2019: 徳島大学, 大学院医歯薬学研究部(薬学域), 教授
Affiliation (based on the past Project Information) *help	2017 – 2019: 徳島大学, 大学院医歯薬学研究部(薬学域), 教授 2016 – 2017: 徳島大学, 大学院医歯薬学研究部(薬学系), 教授 2015 – 2016: 徳島大学, 大学院医歯薬学研究部, 教授 2011 – 2014: 徳島大学, ヘルスバイオサイエンス研究部, 教授 2005 – 2013: The University of Tokushima, Institute of Health Biosciences, Professor, 大学院・ヘルスバイオサイエンス研究部, 教授 … More
Review Section/Research Field	Principal Investigator Drug development chemistry / Chemical pharmacy / Science and Engineering / Biological Sciences / Chemical pharmacy / Living organism molecular science / Pharmaceutical Sciences and related fields Except Principal Investigator 医薬分子機能学 / Biological Sciences / Chemical pharmacy … More
Keywords	Principal Investigator ペプチド合成 / リン酸化ペプチド / チオエステル / リン酸化 / 最終脱保護 / ペプチド / アシル転移 / ホスファターゼ / 細胞内情報伝達 / ホスファターゼ抵抗性 … More Except Principal Investigator 膜融合阻害剤 / CXCR4アンタゴニスト / T140 / 環状ペプチド / 細胞がん化 / ヒトがん細胞 / MAPキナーゼ / MAPキナーゼ・キナーゼ / 阻害剤 / アポトーシス / マラリア / Plasmepsin II / aza-Payne転位反応 / 基質遷移状態模倣型酵素阻害剤 / CXCR4 / gp41 / 脂質膜 / HIV侵入阻害剤 / T細胞指向性HIV-1 / de novo設計 / 低分子化 / 有機銅試薬 / ボンベシンアンタゴニスト / 抗腫瘍活性 / Bombesin Antagonist / ペプチドイソスター / 立体配座固定 / 癌 / エイズ / HIVプロテアーゼ阻害剤 / CXCR4拮抗剤 / Constitutively Active Receptor Technology / Ras / フラボン / MEK阻害剤 / 増殖阻害 / pp125^<FAK> / Plasmodium falciparum / ChondroitinsulfateA / Duffy-結合様ドメイン / マラリアワクチン / トロージャンペプチド / p16 / Bcl-X遺伝子 / アンチセンス・オリゴヌクレオチド / 遺伝子治療 / 膵癌 / HIV外皮蛋白質gp41 / 6-helical bundle構造 / 薬剤耐性型抗HIV剤 / de novoデザイン / 6 helical bundle構造 / SC34 / 人工設計 / X線結晶解析 / ケモカインレセプター / 受容体 / 膜タンパク質 / ペプチドチオエステル / 脂質二重膜 / タンパク質合成 / HIV / リポソーム / 非ペプチド化 / 天然物 / 不斉合成 / 創薬 / 標的タンパク / ケミカルバイオロジー / ベイト分子 / プルダウン法 / プロテオミクス / 標的タンパク質 / 細胞接着 / プルダウンアッセイ / アスパーギライド / 細胞毒性 / ビオチン / 光親和性標識 / クリックケミストリー / 標的タンパク同定 / エイズウイルス / アスパルチルプロテア-ゼ / 有機銅ールイス酸複合剤 / トランスオレフィン型イソスタ- / Fmoc型固相法 / アルパルチルプロテア-ゼ / AIDS Virus / Aspartyl protease / Inhibitor / organocopper-Lewis Acid Complex / Trans olefin type isostere / Fmoc-Based Solid Phase Synthesis / 活性化アジリジンエノエ-ト / 0価パラジウム / (E)-アルケンジペプチドイソスター / アミラーゼ分泌抑制 / 立体制御合成プロセス / キラルプール / 立体特異的1,3-不斉転移 / (E)-アルケン型ジペプチドイソスター / 遷移金属触媒による異性化反応 / 膵癌細胞増殖抑制 / Organocopper Reagents / Activated Aziridinyl Enoates / Palladium(0) / (E)-Alkene Dipeptide Isosters / Inhibition of Amylase Release / Anti-Cancer Activity / Stereocontrolled Synthetic Route / 有機銅化合物 / ボンベシン・アンタゴニスト / SN2型開環反応 / アルケンイソスター / アジリジニル・エノエイト / ビニルアジリジン / 有機パラジウム化合物 / アリルパラジウム錯体 / トリプトファン・イソスター / トリプトフアン・イソスター / Organocopper Compound / SN2-type Ring-Opening / Alkene Isostere / Aziridinylenoate / Vinylaziridine / Organopalladium Compound / Allylpalladium Complex / 立体的選択的合成反応 / アスパルチルプロテアーゼ / 基質遷移状態模倣型阻害剤 / aza-Payne転位 / β-セクレターゼ / HIVプロテアーゼ / アルケン型ジペプチドイソスター / ゲノム情報集約型ライブラリー / αVβ3インテグリン拮抗剤剤 / アルツハイマー型痴呆症 / 有機亜鉛-銅複合試薬 / ペプチドリード医薬品 / Ru-触媒メタセシス閉環反応 / グローバル配座固定 / β-secretase / 多剤耐性HIV型プロテアーゼ / オレフィンメタセシス閉環反応 / (E)-Alkcnc型dipcptidcisostcrc / 非天然型アミノ酸誘導体 / 基質遷移状態ミミック構造 / 遷移金属触媒 / ケモカインアンタゴニスト / Stereoselective Synthesis / Aspartyl Protease / Substrate Transition State Mimic / aza-Payne Rearrangement / β-Secretase / HIV-protease / Organocopper Reagent / Alkene-type tipeptide isostere / HIV進入阻害剤 / CXCR4ケモカインレセプター / T細胞指向性HIV / 多剤耐性HIV / de novo分子設計 / 環状ペンタペプチドライブラリー / ホモロジーモデリング / 機能性CXCR4変異体 / T140-CXCR4ドッキング解析 / FC131 / gp41-標的型HIV-Cell膜融合阻害剤 / SC34EK / spring8 / HIV-cell融合阻害剤 / 多剤耐性克服型抗HIV剤 / 二価官能性抗HIV剤 / HIV第二受容体拮抗剤 / CXCR4ケモカイン受容体 / T140立体構造 / 逆転写酵素阻害 / エイス / コンビナトリアル合成 / 有用金属試薬 / anti-HIV agents / chemokine receptor / T-cell line-tropic HIV / low molecular weight CXCR4 antagonists / HIV-cell fusion inhibitors / de novo design / ゲノム科学 / 創薬研究 / ペプチド化学 / Chemical Ligation / 7回膜貫通型GPCR / ゲノム情報 / 蛋白質化学 / 創薬テンプレート / 7回膜貫通型レセプター / HIV感染 / Germinal Center / リウマチ / ゲノム / プロテオーム / SARS Corona Virus / 7TM-GPCR / αVβ3-integrin / ユニバーサル創薬テンプレート / genome science / drug discovery / peptide-isosteres / Peptide Chemistry / CXCR4 antagonist / chemical ligation / G-protein coupled receptor / アポリポタンパク質 / HDL / コンフォメーション / 抗体 / アミロイド / 糖鎖 / ＨＤＬ / コレステロール代謝 / 脂質異常症 / アミロイドーシス / ABCトランスポーター / トリメチルロック / 機能制御 / ペプチド / タンパク質 / 刺激応答 / ラクトン化 / アミド結合切断 / ペプチド結合切断 / 活性制御 / 刺激応答型アミノ酸 Less

Development of fluorescence probe for visualization of in-cell methylation eventsPrincipal Investigator
- Principal Investigator
  
  大高章
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Challenging Research (Exploratory)
- Research Field
  
  Pharmaceutical Sciences and related fields
- Research Institution
  The University of Tokushima
次世代タンパク性医薬品開発に向けた反応システム系の開発と展開Principal InvestigatorOngoing
- Principal Investigator
  
  大高章
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokushima
Synthetic Study on Semi-synthetic AntibodyPrincipal Investigator
- Principal Investigator
  
  OTAKA Akira
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokushima
Development of a stimulus-responsive amino acid that enables functional control of peptides and proteins
- Principal Investigator
  
  SHIGENAGA Akira
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokushima
Development of highly efficient labelling reagents for proteinPrincipal Investigator
- Principal Investigator
  
  OTAKA Akira
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokushima
Physicochemical mechanism on formation and metabolism of HDL particles by apolipoproteins
- Principal Investigator
  
  Saito Hiroyuki
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto Pharmaceutical University
  The University of Tokushima
分子標的探索のための化学選択的修飾部位内在型リンカーの開発Principal Investigator
- Principal Investigator
  
  大高章
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokushima
Development of synthetic platoform of proteinsPrincipal Investigator
- Principal Investigator
  
  OTAKA Akira
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokushima
Development and application of efficient identification method for drugable proteins based on natural products and bioorganic chemistries
- Principal Investigator
  
  SHISHIDO Kozo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokushima
Development of methodology forchemical synthesis of proteins based on kinetically controlled peptide bond formationPrincipal Investigator
- Principal Investigator
  
  OTAKA Akira
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokushima
Development of methodologies for catalytic decomposition of proteinsPrincipal Investigator
- Principal Investigator
  
  OTAKA Akira
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokushima
化学的アミド結合切断を基盤とする時空間制御型タンパク質機能発現調節法の開発Principal Investigator
- Principal Investigator
  
  大高章
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Living organism molecular science
- Research Institution
  The University of Tokushima
ウイルスの共通分子機構を標的とする抗ウイルスペプチドの開発戦略の創製Principal Investigator
- Principal Investigator
  
  大高章
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokushima
Davelopment of methodology for the preparation of membrane proteinsPrincipal Investigator
- Principal Investigator
  
  OTAKA Akira
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokushima
ウイルスの共通分子機構を標的とする抗ウイルスペプチドの開発戦略の創製Principal Investigator
- Principal Investigator
  
  大高章
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokushima
CXCR4とgp41をダブルターゲットとした人工設計型HIV侵入阻害剤の創製研究
- Principal Investigator
  
  玉村啓和
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
人工スプライシングシステムの構築と不溶性蛋白質合成への展開Principal Investigator
- Principal Investigator
  
  大高章
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyoto University
Development of anti-HIV-1 peptides based on the concept of the discrimination of helical surfacesPrincipal Investigator
- Principal Investigator
  
  OTAKA Akira
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokushima
  Kyoto University
HIV外皮蛋白断片gp41-C34を基にした人工設計型細胞融合阻害剤の創製研究
- Principal Investigator
  
  玉村啓和
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
ケミカルレセプトームの開発と応用
- Principal Investigator
  
  藤井信孝
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  医薬分子機能学
- Research Institution
  Kyoto University
Genome/Proteome-lead Drug Discovery Based on Peptide/Protein Chemistry
- Principal Investigator
  
  FUJII Nobutaka
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kyoto University
HIV外皮蛋白断片gp41-C34を基にした人工設計型細胞融合阻害剤の創製研究
- Principal Investigator
  
  TAMAMURA Hirokazu
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Synthesis of Fluoroalkene Dipeptide Isosteres Using Organocopper ReagentsPrincipal Investigator
- Principal Investigator
  
  OTAKA Akira
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  KYOTO UNIVERSITY
細胞周期調節機能を有するペプチドの創製と抗がん剤への展開研究Principal Investigator
- Principal Investigator
  
  大高章
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
非ウイルス性ベクターによる膵癌治療法の開発
- Principal Investigator
  
  HOSOTANI Ryo
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
DEVELOPMENT OF NOVEL ANTI -HIV AGENTS BASED ON HIGHLY' SELECTIVE CHEMOKINE RECEPTOR CXCR$ ANTAGONISTS
- Principal Investigator
  
  FUJII Nobutaka
- Project Period (FY)
  2000 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  KYOTO UNIVERSITY
マラリア原虫の増殖機構をターゲットとする新規マラリア治療薬の開発研究
- Principal Investigator
  
  藤井信孝
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
(E)-アルケンペプチドイソスターを探索子とする高活性GRP拮抗剤の創製Principal Investigator
- Principal Investigator
  
  大高章
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
Studies on Practical Strategy for Peptide-lead Drug Discovery and Development
- Principal Investigator
  
  FUJII Nobutaka
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  KYOTO UNIVERSITY
Synthesis of secondary difluoromethylphosphonate-contaning amino acid and its biological examinationPrincipal Investigator
- Principal Investigator
  
  OTAKA Akira
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  KYOTO UNIVERSITY
生体内情報伝達機構解明を指向したホスファターゼ抵抗性リン酸化ペプチドの合成Principal Investigator
- Principal Investigator
  
  大高章
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
ヒトがん細胞におけるMAPキナーゼカスケードの異常-細胞がん化との相関
- Principal Investigator
  
  河野通明
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagasaki University
(E)-アルケンペプチドイソスターを探索子とする高活性GRP拮抗剤の創製Principal Investigator
- Principal Investigator
  
  大高章
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Development of highly efficient, selective, and practical synthetic method of pseudo-peptides possessing anti-tumour activity.
- Principal Investigator
  
  FUJII Nobutaka, 井深俊郎
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  KYOTO UNIVERSITY
生体内情報伝達機構解明を指向したホスファターゼ抵抗性リン酸化ペプチドの合成Principal Investigator
- Principal Investigator
  
  大高章
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
MAPキナーゼカスケードを構成するシグナル分子を標的とした細胞増殖阻害物質の検索
- Principal Investigator
  
  河野通明
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Gifu Pharmaceutical University
Synthesis of Peptide Isosteres with Strong Bombesin Antagonist Activity and Its Development to Anti-Cancer Agents
- Principal Investigator
  
  FUJII Nobutaka
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  KYOTO UNIVERSITY
Development of Practical Synthetic Method for Phosphopeptides using Two-step Deprotecting ProceduresPrincipal Investigator
- Principal Investigator
  
  OTAKA Akira
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  KYOTO UNIVERSITY
生体内情報伝達機構解明を指向したホスファターゼ抵抗性リン酸化ペプチドの合成Principal Investigator
- Principal Investigator
  
  大高章
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
新規最終脱保護系を用いた高効率リン酸化ペプチドの合成法の開発に関する研究Principal Investigator
- Principal Investigator
  
  大高章
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto University
Development of efficient synthetic methods for peptides and syntheses of self-defense peptides possessing anti-virus activityPrincipal Investigator
- Principal Investigator
  
  OTAKA Akira
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  KYOTO UNIVERSITY
Deveropment of the Anti-AIDS Drug Based on the Aspartyl Protease Inhbitor
- Principal Investigator
  
  FUNAKOSHI Susumu
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto University

[Book] 医療・診断をささえるペプチド科学―再生医療・DDS・診断への応用―2017
- Author(s)
  大高　章、重永　章
- Total Pages
  7
- Publisher
  株式会社シーエムシー出版
- ISBN
  9784781312675
- Data Source
  KAKENHI-PROJECT-16H02611
[Book] 「生物活性小分子の結合パートナータンパク質を知りたい　－リンカー分子を用いたタンパク質精製法－」実験医学増刊号驚愕の代謝システム～メタボロームの階層から解き明かす疾患研究の新たなステージ～2014
- Author(s)
  重永　章、山本　純、大高　章
- Total Pages
  204
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-24390026
[Book] 「生物活性小分子の結合パートナータンパク質を知りたい　－リンカー分子を用いたタンパク質精製法－」実験医学増刊号驚愕の代謝システム～メタボロームの階層から解き明かす疾患研究の新たなステージ～2014
- Author(s)
  重永　章、山本　純、大高　章
- Total Pages
  204
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-25670058
[Book] 生体有機化学・12章　生理活性ペプチドホルモン2012
- Author(s)
  大高　章
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-23390026
[Book] 刺激応答型アミノ酸の開発と生命科学分野への応用」遺伝子医学 MOOK 21 号最新ペプチド合成技術とその創薬研究への応用2012
- Author(s)
  重永章、山本純、大高章
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-23659055
[Book] 生体有機化学・12章　生理活性ペプチドホルモン2012
- Author(s)
  大高　章
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PUBLICLY-24102521
[Book] 「第12 章生理活性ペプチドホルモン」生体有機化学2012
- Author(s)
  大高章
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-23659055
[Book] 生体有機化学・12章生理活性ペプチドホルモン2012
- Author(s)
  大高章
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-24390026
[Book] 生体有機化学・12章　生理活性ペプチドホルモン2012
- Author(s)
  大高　章
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-23659055
[Book] 刺激応答型アミノ酸の開発と生命科学分野への応用2012
- Author(s)
  重永章、山本純、大高章
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-21390031
[Book] 刺激応答型アミノ酸の開発と生命科学分野への応用, 遺伝子医学MOOK 21 号最新ペプチド合成技術とその創薬研究への応用(木曽良明編)2012
- Author(s)
  重永章, 山本純, 大高章
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-23390026
[Book] 第10章最近のペプチド・タンパク質の化学合成について2010
- Author(s)
  大高章、重永章
- Publisher
  建帛社
- Data Source
  KAKENHI-PROJECT-21390031
[Book] 機能性タンパク質・ペプチドの生体利用(第10章最近のペプチド・タンパク質の化学合成について)2010
- Author(s)
  大高章
- Total Pages
  27
- Publisher
  建帛社
- Data Source
  KAKENHI-PROJECT-21390031
[Book] 新しい薬をどう創るか(ブルーバックス)2008
- Author(s)
  大高章, 他京都大学大学院薬学研究科編
- Publisher
  講談社
- Data Source
  KAKENHI-PROJECT-18390006
[Book] 新しい薬をどう創るか(ブルーバックス)2008
- Author(s)
  大高章, 他京都大学大学院薬学研究科編
- Publisher
  講談社
- Data Source
  KAKENHI-PROJECT-19651096
[Journal Article] A recyclable hydrophobic anchor‐tagged asymmetric amino thiourea catalyst2018
- Author(s)
  Jichu Takahisa、Inokuma Tsubasa、Aihara Keisuke、Kohiki Taiki、Nishida Kodai、Shigenaga Akira、Yamada Ken-ichi、Otaka Akira
- Journal Title
  
  ChemCatChem
  
  Volume: 10 Pages: 3402-3405
- DOI
  10.1002/cctc.201800714
- NAID
  120006652009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06579, KAKENHI-PROJECT-18K14869, KAKENHI-PROJECT-17K19492
[Journal Article] Direct Enantioselective Indolylation of Peptidyl Imine for the Synthesis of Indolyl Glycine-Containing Peptides2018
- Author(s)
  Inokuma, T.; Nishida, K.; Shigenaga, A.; Yamada, K.; Otaka, A.
- Journal Title
  
  HETEROCYCLES
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02611
[Journal Article] ピンサー型錯体　有機カルコゲン化合物　曲面π共役分子　Native Chemical Ligation法2018
- Author(s)
  大髙　章、重永　章
- Journal Title
  
  J. Syn. Org. Chem., Jpn.
  
  Volume: 76 Issue: 1 Pages: 45-54
- DOI
  10.5059/yukigoseikyokaishi.76.66
- NAID
  130006313514
- ISSN
  0037-9980, 1883-6526
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02611
[Journal Article] Resin-Bound Crypto-Thioester for Native Chemical Ligation2018
- Author(s)
  Naruse, N.; Ohakawachi, K.; Inokuma, T.; Shigenaga, A.; Otaka, A.
- Journal Title
  
  Organic Letters
  
  Volume: 20 Pages: 2449-2453
- DOI
  10.1021/acs.orglett.8b00795
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17J03475, KAKENHI-PROJECT-16H02611
[Journal Article] Light-induced propulsion of a giant liposome driven by peptide nanofibre growth2018
- Author(s)
  Inaba Hiroshi、Uemura Akihito、Morishita Kazushi、Kohiki Taiki、Shigenaga Akira、Otaka Akira、Matsuura Kazunori
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Pages: 6243-6243
- DOI
  10.1038/s41598-018-24675-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02611
[Journal Article] Protein Synthetic Chemistry Inspired by Intein-mediated Protein Splicing2018
- Author(s)
  Otaka Akira、Shigenaga Akira
- Journal Title
  
  J. Syn. Org. Chem., Jpn.
  
  Volume: 76 Issue: 1 Pages: 45-54
- DOI
  10.5059/yukigoseikyokaishi.76.45
- NAID
  130006313519
- ISSN
  0037-9980, 1883-6526
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02611
[Journal Article] Direct Enantioselective Indolylation of Peptidyl Imine for the Synthesis of Indolyl Glycine-Containing Peptides2018
- Author(s)
  Otaka Akira、Yamada Ken-ichi、Inokuma Tsubasa、Nishida Kodai
- Journal Title
  
  HETEROCYCLES
  
  Volume: 97 Pages: 1269-1269
- DOI
  10.3987/com-18-s(t)86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06579, KAKENHI-PROJECT-17K19492
[Journal Article] Effect of Phosphatidylserine and Cholesterol on Membrane-mediated Fibril Formation by the N-terminal Amyloidogenic Fragment of Apolipoprotein A-I2018
- Author(s)
  Mizuguchi Chiharu、Nakamura Mitsuki、Kurimitsu Naoko、Ohgita Takashi、Nishitsuji Kazuchika、Baba Teruhiko、Shigenaga Akira、Shimanouchi Toshinori、Okuhira Keiichiro、Otaka Akira、Saito Hiroyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Pages: 5497-5497
- DOI
  10.1038/s41598-018-23920-3
- NAID
  120006535031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-16J01828, KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-17H03979, KAKENHI-PROJECT-17K19492, KAKENHI-PROJECT-17K16123
[Journal Article] ProteoFind: A script for finding proteins that are suitable for chemical synthesis2018
- Author(s)
  Shigenaga, A.; Naruse, N.; Otaka, A.
- Journal Title
  
  Tetrahedron
  
  Volume: 74 Pages: 2291-2297
- DOI
  10.1016/j.tet.2018.03.030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17J03475, KAKENHI-PROJECT-15K07858, KAKENHI-PROJECT-16H02611
[Journal Article] CXCL14 acts as a specific carrier of CpG DNA into dendritic cells and activates toll-like receptor 9-mediated adaptive immunity2017
- Author(s)
  Tanegashima Kosuke、Takahashi Rena、Nuriya Hideko、Iwase Rina、Naruse Naoto、Tsuji Kohei、Shigenaga Akira、Otaka Akira、Hara Takahiko
- Journal Title
  
  EbioMedicine
  
  Volume: 24 Pages: 247-256
- DOI
  10.1016/j.ebiom.2017.09.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-16H04728, KAKENHI-PROJECT-17J03475
[Journal Article] An aromatic amino acid within intracellular loop 2 of the prostaglandin EP2 receptor is a prerequisite for selective association and activation of Gαs2017
- Author(s)
  Yano A, Takahashi Y, Moriguchi H, Inazumi T, Koga T, Otaka A, Sugimoto Y.
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  
  Volume: 1862 Pages: 615-622
- DOI
  10.1016/j.bbalip.2017.03.006
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-15H05897, KAKENHI-PROJECT-15K19032, KAKENHI-PROJECT-15K18875, KAKENHI-PLANNED-15H05905, KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-17H03990, KAKENHI-PROJECT-26670030
[Journal Article] Stapled BIG3 helical peptide ERAP extends potent antitumor activity for breast cancer therapeutics.2017
- Author(s)
  Yoshimaru T, Aihara K, Komatsu M, Matsushita Y, Okazaki Y, Toyokuni S, Honda J, Sasa M, Miyoshi Y, Otaka A, Katagiri T
- Journal Title
  
  Scientific Reports
  
  Volume: 印刷中 Pages: 1821-1821
- DOI
  10.1038/s41598-017-01951-6
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461948, KAKENHI-PROJECT-17K19492, KAKENHI-PUBLICLY-16H01575, KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-16H05153
[Journal Article] 第３章第３節　ペプチドの不安定性を解決するペプチド結合の置換技術2017
- Author(s)
  大髙　章、鳴海哲夫
- Journal Title
  
  ペプチド医薬品のスクリーニング・安定化・製剤化技術（株式会社技術情報協会）
  
  Volume: - Pages: 130-140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02611
[Journal Article] Elucidation of inhibitor-binding pocket of D-amino acid oxidase using docking simulation and N-sulfanylethylanilide-based labeling technology2017
- Author(s)
  Taiki Kohiki, Yusuke Kato, Yusuke Nishikawa, Kazuko Yorita, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Akira Shigenaga*, Kiyoshi Fukui*, Akira Otaka*
- Journal Title
  
  Org. Biomol. Chem. (Inside Front Cover)
  
  Volume: 15 Pages: 5289-5297
- DOI
  10.1039/c7ob90109g
- NAID
  120006493365
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07858
[Journal Article] A Convenient Method for Preparation of α-Imino Carboxylic Acid Derivatives and Application to the Asymmetric Synthesis of Unnatural α-Amino Acid Derivative2017
- Author(s)
  Inokuma Tsubasa、Jichu Takahisa、Nishida Kodai、Shigenaga Akira、Otaka Akira
- Journal Title
  
  CHEMICAL & PHARMACEUTICAL BULLETIN
  
  Volume: 65 Issue: 6 Pages: 573-581
- DOI
  10.1248/cpb.c17-00158
- NAID
  130005686014
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02611
[Journal Article] Elucidation of inhibitor-binding pocket of D-amino acid oxidase using docking simulation and N-sulfanylethylanilide-based labeling technology.2017
- Author(s)
  Kohiki, T.; Kato, Y.; Nishikawa, Y.;Yorita, K.; Sagawa, I.; Denda, M.; Inokuma, T.; Shigenaga, A.; Fukui, K.; Otaka, A.
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 15 Pages: 5289-5297
- DOI
  10.1039/c7ob00633k
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19492, KAKENHI-PROJECT-16H02611
[Journal Article] Invention of stimulus-responsive peptide-bond-cleaving residue (Spr) and its application to chemical biology tools2017
- Author(s)
  Akira Shigenaga*, Jun Yamamoto, Taiki Kohiki, Tsubasa Inokuma, Akira Otaka*
- Journal Title
  
  J. Pept. Sci. (Akabori Special Issue, Review)
  
  Volume: 23 Pages: 505-513
- DOI
  10.1002/psc.2961
- NAID
  120006493367
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07858
[Journal Article] Cysteine-Free Intramolecular Ligation of N-Sulfanylethylanilide Peptide Using 4-Mercaptobenzylphosphonic Acid: Synthesis of Cyclic Peptide Trichamide2017
- Author(s)
  Otaka Akira、Aihara Keisuke、Inokuma Tsubasa、Jichu Takahisa、Lin Zhenjian、Fu Feixue、Yamaoka Kosuke、Shigenaga Akira、Hutchins David、Schmidt Eric
- Journal Title
  
  Synlett
  
  Volume: 28 Pages: 1944-1949
- DOI
  10.1055/s-0036-1589055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02611
[Journal Article] Chemical Synthetic Platform for Chlorpromazine Oligomers That Were Reported as Photo-degradation Products of Chlorpromazine2017
- Author(s)
  Kohiki Taiki、Nishikawa Yusuke、Inokuma Tsubasa、Shigenaga Akira、Otaka Akira
- Journal Title
  
  CHEMICAL & PHARMACEUTICAL BULLETIN
  
  Volume: 65 Issue: 12 Pages: 1161-1166
- DOI
  10.1248/cpb.c17-00692
- NAID
  130006235035
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19492, KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-15K07858
[Journal Article] An N-sulfanylethylanilide-based traceable linker for enrichment and selective labelling of target proteins.2016
- Author(s)
  Takuya Morisaki, Masaya Denda, Jun Yamamoto, Daisuke Tsuji, Kohji Itoh, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka
- Journal Title
  
  Chem Commun
  
  Volume: 52 Pages: 6911-6913
- DOI
  10.1039/c6cc01229a
- NAID
  120006493363
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293120, KAKENHI-PROJECT-15K07858, KAKENHI-PROJECT-15KK0309
[Journal Article] Labelling of endogenous target protein via N-S acyl transfer-mediated activation of N-sulfanylethylanilide2016
- Author(s)
  Denda, M.; Morisaki, T.; Kohiki, T.; Yamamoto, J.; Sato, K.; Sagawa, I.; Inokuma, T.; Sato, Y.; Yamauchi, A.; Shigenaga, A.*; Otaka, A.*
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 14 Pages: 6244-6251
- DOI
  10.1039/c6ob01014h
- NAID
  120006489009
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07858, KAKENHI-PROJECT-16K21077
[Journal Article] Heparin Promotes Fibril Formation by the N-Terminal Fragment of Amyloidogenic Apolipoprotein A-I.2016
- Author(s)
  Mikawa, S., Mizuguchi, C., Nishitsuji, K., Baba, T., Shigenaga,A., Shimanouchi, T., Sakashita, N., Otaka, A., Akaji, K., Saito, H.
- Journal Title
  
  FEBS Letter
  
  Volume: 590(20) Pages: 3492-3500
- DOI
  10.1002/1873-3468.12426
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16J01828, KAKENHI-PROJECT-25293006, KAKENHI-PROJECT-15K19488, KAKENHI-PROJECT-16K08712
[Journal Article] Tailored synthesis of 162-residue S-monoglycosylated GM2-activator protein (GM2AP) analogues that allows facile access to protein library2016
- Author(s)
  Nakamura, T.; Sato, K.; Naruse, N.; Kitakaze, K.; Inokuma, T.; Hirokawa, T.; Shigenaga, A.; Itoh, K.; Otaka, A.
- Journal Title
  
  ChemBioChem
  
  Volume: 17 Pages: 1986-1992
- DOI
  10.1002/cbic.201600400
- NAID
  120006489005
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-16J08106, KAKENHI-PROJECT-26293120, KAKENHI-PROJECT-15K14979, KAKENHI-PROJECT-16K21077
[Journal Article] N-Sulfanylethylaminooxybutyramide (SEAoxy): A Crypto-Thioester Compatible with Fmoc Solid-Phase Peptide Synthesis.2016
- Author(s)
  Tsuda, S.; Mochizuki, M.; Sakamoto, K.; Denda, M.; Nishio, H.; Otaka, A.; Yoshiya, T.
- Journal Title
  
  Org. Lett.
  
  Volume: 18 Pages: 5940-5943
- DOI
  10.1021/acs.orglett.6b03055
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-15K14979
[Journal Article] 天然アミノ酸配列に適用可能な新規タンパク質チオエステル合成法の開発2016
- Author(s)
  津田雄介、重永　章、佐藤浩平、中村太寛、北風圭介、猪熊　翼、伊藤孝司、大髙　章
- Journal Title
  
  ケミカルバイオロジー
  
  Volume: 9 Pages: 7-10
- NAID
  40021146446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K14979
[Journal Article] One-pot/sequential native chemical ligation using photocaged crypto-thioester.2016
- Author(s)
  Keisuke Aihara, Kosuke Yamaoka, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka
- Journal Title
  
  Org. Lett.
  
  Volume: 18 Pages: 596-599
- DOI
  10.1021/acs.orglett.5b03661
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14979, KAKENHI-PROJECT-14J07568, KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-15K07858
[Journal Article] Development of an intein-inspired amide cleavage chemical device.2016
- Author(s)
  Komiya, C.; Aihara, K.; Morishita, K.; Ding, H.; Inokuma, T.; Shigenaga, A.; Otaka, A.*
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 81 Pages: 699-707
- DOI
  10.1021/acs.joc.5b02399
- NAID
  120006493349
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07858, KAKENHI-PROJECT-15K14979, KAKENHI-PROJECT-14J07568, KAKENHI-PROJECT-16H02611
[Journal Article] Facile synthesis of C-terminal peptide thioacids under mild conditions from N-sulfanylethylanilide peptides.2016
- Author(s)
  Shimizu, T.; Miyajima, R.; Sato, K.; Sakamoto, K.; Naruse, N.; Kita, M.; Shigenaga, A.*; Otaka, A.*
- Journal Title
  
  Tetrahedron
  
  Volume: 72 Pages: 992-998
- DOI
  10.1016/j.tet.2015.12.070
- NAID
  120006493362
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07858, KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-15K14979
[Journal Article] Formation of stable nanodiscs by bihelical apolipoprotein A-I mimetic peptide.2016
- Author(s)
  Kariyazono, H., Nadai, R., Miyajima, R., Takechi-Haraya, Y., Baba, T., Shigenaga, A., Okuhira, K., Otaka, A., and Saito, H.
- Journal Title
  
  J Pept Sci.
  
  Volume: 22 Pages: 116-122
- DOI
  10.1002/psc.2847
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293006, KAKENHI-PROJECT-16K08236
[Journal Article] Development of an anilide-type scaffold for the thioester precursor N-Sulfanylethylcoumarinyl amide2016
- Author(s)
  Eto, M.; Naruse, N.; Morimoto, K.; Yamaoka, K.; Sato, K.; Tsuji, K.; Inokuma, T.; Shigenaga, A.; Otaka, A.
- Journal Title
  
  Org. Lett.
  
  Volume: 18 Pages: 4416-4419
- DOI
  10.1021/acs.orglett.6b02207
- NAID
  120006489004
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-15K14979, KAKENHI-PROJECT-15K07858, KAKENHI-PROJECT-16K21077
[Journal Article] Preparation of peptide thioesters from naturally occurring sequences using reaction sequence consisting of regioselective S- cyanylation and hydrazinolysis2016
- Author(s)
  Rin Miyajima, Yusuke Tsuda, Tsubasa Inokuma, Akira Shigenaga, Miki Imanishi, Shiro Futaki and Akira Otaka
- Journal Title
  
  Biopolymers (Peptide Science, Special Issue: Emerging Peptide Science from Japan)
  
  Volume: － Pages: 531-546
- DOI
  10.1002/bip.22757
- NAID
  120006493350
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14979, KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-15K07858
[Journal Article] 天然アミノ酸配列に適用可能な新規タンパク質チオエステル合成法の開発2016
- Author(s)
  津田雄介、重永　章、佐藤浩平、中村太寛、北風圭介、猪熊　翼、伊藤孝司、大髙　章
- Journal Title
  
  ケミカルバイオロジー
  
  Volume: 9 Pages: 7-10
- NAID
  40021146446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02611
[Journal Article] Facile Preparation of Peptides with C-Terminal <i>N</i>-Alkylamide <i>via</i> Radical-Initiated Dethiocarboxylation2016
- Author(s)
  Shimizu, T.; Miyajima, R.; Naruse, N.; Yamaoka, K.; Aihara, K.; Shigenaga, A.*; Otaka, A.*
- Journal Title
  
  CHEMICAL & PHARMACEUTICAL BULLETIN
  
  Volume: 64 Issue: 4 Pages: 375-378
- DOI
  10.1248/cpb.c15-01025
- NAID
  130005141024
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07858, KAKENHI-PROJECT-14J07568, KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-15K14979
[Journal Article] Enthalpy-driven interactions with sulfated glycosaminoglycans promote cell membrane penetration of arginine peptides2016
- Author(s)
  Takechi-Haraya, Y., Nadai, R., Kimura, H., Nishitsuji, K., Uchimura, K., Sakai-Kato, K., Kawakami, K. Shigenaga, A., Kawakami, T., Otaka, A., Hojo, H., Sakashita, N., and Saito, H.
- Journal Title
  
  BBA - Biomembranes
  
  Volume: 1858 Pages: 1339-1349
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293006
[Journal Article] Chemical synthesis of proteins using N-sulfanylethylanilide peptides, based on N-S acyl transfer chemistry2015
- Author(s)
  A. Otaka, K. Sato, A. Shigenaga
- Journal Title
  
  Topics Current Chem
  
  Volume: in press
- DOI
  10.1007/128_2014_586
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390026, KAKENHI-PROJECT-25670058
[Journal Article] Development of chemical methodology for preparation of peptide thioesters applicable to naturally occurring peptides using a sequential quadruple acyl transfer system.2015
- Author(s)
  Yusuke Tsuda, Akira Shigenaga, Masaya Denda, Kohei Sato, Keisuke Kitakaze, Takahiro Nakamura, Tsubasa Inokuma, Kouji Itou and Akira Otaka
- Journal Title
  
  ChemistryOpen
  
  Volume: 4 Pages: 448-452
- DOI
  10.1002/open.201500086
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14979, KAKENHI-PROJECT-15J09928, KAKENHI-PROJECT-26670269, KAKENHI-PROJECT-26293120
[Journal Article] Efficient one-pot synthesis of CXCL14 and its derivative using an N-sulfanylethylanilide peptide as a peptide thioester equivalent and their biological evaluation2015
- Author(s)
  Kohei Tsuji, Kosuke Tanegashima, Kohei Sato, Ken Sakamoto, Akira Shigenaga, Tsubasa Inokuma, Takahiko Hara and Akira Otaka
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 23 Pages: 5909-5914
- DOI
  10.1016/j.bmc.2015.06.064
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14979, KAKENHI-PROJECT-25860304
[Journal Article] Amyloidogenic Mutation Promotes Fibril Formation of the N-terminal Apolipoprotein A-I on Lipid Membranes.2015
- Author(s)
  Mizuguchi, C., Ogata, F., Mikawa, S., Tsuji, K., Baba, T., Shigenaga, A., Shimanouchi, T., Okuhira, K., Otaka, A., and Saito, H.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 290 Pages: 20947-20959
- DOI
  10.1074/jbc.m115.664227
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293006
[Journal Article] Liquid-phase synthesis of bridged peptides using olefin metathesis of protected peptide with long aliphatic chain anchor2015
- Author(s)
  K. Aihara, C. Komiya, A. Shigenaga, T. Inokuma, D. Takahashi and A. Otaka
- Journal Title
  
  Org. Lett.
  
  Volume: 17 Pages: 696-699
- DOI
  10.1021/ol503718j
- NAID
  120006489011
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J07568, KAKENHI-PROJECT-24390026, KAKENHI-PROJECT-24590010, KAKENHI-PROJECT-25670058
[Journal Article] Design and synthesis of a hydrogen peroxide-responsive amino acid that induces peptide bond cleavage after exposure to hydrogen peroxide2015
- Author(s)
  Kita, M.; Yamamoto, J.; Morisaki, T.; Komiya, C.; Inokuma, T.; Miyamoto, L.; Tsuchiya, K.; Shigenaga, A.*; Otaka, A.*
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 56 Pages: 4228-4231
- DOI
  10.1016/j.tetlet.2015.05.060
- NAID
  120006493359
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07858
[Journal Article] The total chemical synthesis of the monoglycosylated GM2 ganglioside activator using a novel cysteine surrogate.2015
- Author(s)
  Kohei Sato, Keisuke Kitakaze, Takahiro Nakamura, Naoto Naruse, Keisuke Aihara, Akira Shigenaga, Tsubasa Inokuma, Daisuke Tsuji, Kouji Itou and Akira Otaka
- Journal Title
  
  Chem Commun (Camb)
  
  Volume: 49 Pages: 9946-9948
- DOI
  10.1039/c5cc02967h
- NAID
  120006489006
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14979, KAKENHI-PROJECT-25460389, KAKENHI-PROJECT-26670269, KAKENHI-PROJECT-26293120
[Journal Article] Molecular complex composed of β-cyclodextrin-grafted chitosan and pH-sensitive amphipathic peptide for enhancing cellular cholesterol efflux under acidic pH.2015
- Author(s)
  Takechi-Haraya, Y., Tanaka, K., Tsuji, K., Asami, Y., Izawa, H., Shigenaga, A., Otaka, A., Saito, H., and Kawakami, K.
- Journal Title
  
  Bioconjugate Chem.
  
  Volume: 26 Pages: 572-581
- DOI
  10.1021/acs.bioconjchem.5b00037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293006
[Journal Article] ペプチド・タンパク質を基盤とする創薬展開への化学基盤の開拓2014
- Author(s)
  佐藤浩平、大高　章
- Journal Title
  
  化学工業
  
  Volume: 6 Pages: 411-417
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25670058
[Journal Article] Development of a Fluoride-responsive Amide Bond Cleavage Device that is Potentially Applicable to a Traceable Linker.2014
- Author(s)
  J. Yamamoto, N. Maeda, C. Komiya, T. Tanaka, M. Denda, K. Ebisuno, W. Nomura, H. Tamamura, Y. Sato, A. Yamauchi, A. Shigenaga, and A. Otaka
- Journal Title
  
  Tetrahedron
  
  Volume: 70 Pages: 5122-5127
- DOI
  10.1016/j.tet.2014.05.110
- NAID
  120006493358
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J07086, KAKENHI-PROJECT-23390026, KAKENHI-PROJECT-24390026, KAKENHI-PROJECT-24590010, KAKENHI-PUBLICLY-25107724, KAKENHI-PROJECT-25410171, KAKENHI-PROJECT-25670058, KAKENHI-PUBLICLY-26119703, KAKENHI-PROJECT-26462461
[Journal Article] タンパク性医薬品開発に向けたペプチド化学2014
- Author(s)
  中村太寛、佐藤浩平、大高　章
- Journal Title
  
  化学工業
  
  Volume: 65 Pages: 842-848
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390026
[Journal Article] タンパク性医薬品開発に向けたペプチド化学2014
- Author(s)
  中村太寛、佐藤浩平、大高　章
- Journal Title
  
  化学工業
  
  Volume: 65 Pages: 849-856
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25670058
[Journal Article] ペプチド・タンパク質を基盤とする創薬展開への化学基盤の開拓2014
- Author(s)
  佐藤浩平、大高　章
- Journal Title
  
  化学工業
  
  Volume: 6 Pages: 411-417
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390026
[Journal Article] 刺激応答型アミノ酸の開発と生命科学分野への展開2014
- Author(s)
  重永　章、大高　章
- Journal Title
  
  化学工業
  
  Volume: 65 Pages: 849-856
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25670058
[Journal Article] The extreme N-terminal region of human apolipoprotein A-I has a strong propensity to form amyloid fibrils2014
- Author(s)
  Adachi, E., Kosaka, A., Tsuji, K., Mizuguchi, C., Kawashima, H., Shigenaga, A., Nagao, K., Akaji, K., Otaka, A., and Saito, H.
- Journal Title
  
  FEBS Letters
  
  Volume: 588 Pages: 389-394
- DOI
  10.1016/j.febslet.2013.11.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293006, KAKENHI-PROJECT-25670014, KAKENHI-PROJECT-25850070
[Journal Article] 刺激応答型アミノ酸の開発と生命科学分野への展開2014
- Author(s)
  重永　章、大高　章
- Journal Title
  
  化学工業
  
  Volume: 65 Pages: 849-856
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390026
[Journal Article] Examination of native chemical ligation using peptidyl prolyl thioester2014
- Author(s)
  T. Nakamura, A. Shigenaga, K. Sato, Y. Tsuda, K. Sakamoto, and A. Otaka.
- Journal Title
  
  Chem. Commun.
  
  Volume: 50 Pages: 58-60
- DOI
  10.1039/c3cc47228k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390026, KAKENHI-PUBLICLY-24102521, KAKENHI-PROJECT-24390026, KAKENHI-PROJECT-24590010, KAKENHI-PUBLICLY-25107724, KAKENHI-PROJECT-25670058
[Journal Article] Development of a Traceable Linker Containing a Thiol-responsive Amino Acid for the Enrichment and Selective Labelling of Target Proteins.2014
- Author(s)
  J. Yamamoto, M. Denda, N. Maeda, M. Kita, C. Komiya, T. Tanaka, W. Nomura, H. Tamamura, Y. Sato, A. Yamauchi, A. Shigenaga, and A. Otaka
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 12 Pages: 3821-3826
- DOI
  10.1039/c4ob00622d
- NAID
  120006510952
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J07086, KAKENHI-PROJECT-23390026, KAKENHI-PROJECT-24390026, KAKENHI-PROJECT-24590010, KAKENHI-PUBLICLY-25107724, KAKENHI-PROJECT-25410171, KAKENHI-PROJECT-25670058, KAKENHI-PUBLICLY-26119703, KAKENHI-PROJECT-26462461
[Journal Article] Development of a traceable linker containing a thiol-responsive amino acid for the enrichment and selective labelling of target proteins2014
- Author(s)
  K. Ebisuno, M. Denda, K. Ogura, T. Inokuma, A. Shigenaga, and A. Otaka
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 22 Pages: 2984-2991
- DOI
  10.1016/j.bmc.2014.04.002
- NAID
  120006510952
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J07086, KAKENHI-PROJECT-24390026, KAKENHI-PROJECT-24590010, KAKENHI-PUBLICLY-25107724, KAKENHI-PROJECT-25670058
[Journal Article] Chemical Synthesis of Biological Active Monoglycosylated GM2-activator Protein Using N-sulfanylethylanilide peptide2013
- Author(s)
  K. Sato, A. Shigenaga, K. Kitakaze, K. Sakamoto, D. Tsuji, K. Itoh, A. Otaka
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: vol.52 Pages: 7855-7859
- DOI
  10.1002/anie.201303390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390026, KAKENHI-PROJECT-23390140, KAKENHI-PROJECT-23659055, KAKENHI-PUBLICLY-24102521, KAKENHI-PROJECT-24390026, KAKENHI-PROJECT-24590010, KAKENHI-PROJECT-24659262, KAKENHI-PUBLICLY-25107724, KAKENHI-PUBLICLY-25110722, KAKENHI-PROJECT-25460389, KAKENHI-PROJECT-25670058
[Journal Article] CXCL14 is a natural inhibitor of the CXCL12-CXCR4 signaling axis.2013
- Author(s)
  K. Tanegashima, K. Suzukia, Y. Nakayama, K. Tsuji, A. Shigenaga, A. Otaka, and T. tiara
- Journal Title
  
  FEBS Lett.
  
  Volume: 587 Pages: 1731-1735
- DOI
  10.1016/j.febslet.2013.04.046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J08863, KAKENHI-PROJECT-22791043, KAKENHI-PROJECT-23659055, KAKENHI-PROJECT-23659481, KAKENHI-PROJECT-25860304, KAKENHI-PUBLICLY-23126528
[Journal Article] Synthetic procedure for N-Fmoc amino acyl-N-sulfanylethylaniline linker as crypto-peptide thioester precursor with application to native chemical ligation2012
- Author(s)
  Sakamoto K, et al.
- Journal Title
  
  J. Org. Chem.
  
  Volume: 77 Pages: 6948-6958
- DOI
  10.1021/jo3011107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J08863, KAKENHI-PROJECT-23390026, KAKENHI-PROJECT-23659055, KAKENHI-PROJECT-24390026, KAKENHI-PROJECT-24590010, KAKENHI-PUBLICLY-23107523, KAKENHI-PUBLICLY-24102521
[Journal Article] One-pot/sequential native chemical ligation using N-sulfanylethylanilide peptide2012
- Author(s)
  Otaka A
- Journal Title
  
  Chem. Record
  
  Volume: 12 Pages: 479-490
- DOI
  10.1002/tcr.201200007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390026, KAKENHI-PROJECT-23659055, KAKENHI-PROJECT-24390026, KAKENHI-PROJECT-24590010, KAKENHI-PUBLICLY-23107523, KAKENHI-PUBLICLY-24102521
[Journal Article] N-Sulfanyl-ethylanilide peptide : a peptide thioester equivalent which can directly participate in native chemical ligation2012
- Author(s)
  Sato, K.; Tsuda, S.; Sakamoto, K.; Shigenaga, A.; Otaka, A
- Journal Title
  
  Peptide Science 2011
  
  Pages: 13-14
- NAID
  10030203930
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031
[Journal Article] Double-kinetically controlled proline ligation2012
- Author(s)
  Ding, H.; Sato, K.; Morishita, K.; Shigenaga, A.; Otaka, A
- Journal Title
  
  Peptide Science 2011
  
  Pages: 133-134
- NAID
  10030204136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031
[Journal Article] Caged ceramide which releases parent ceramide after UV-induced amide bond cleavage followed by intramolecular O-N acyl transfer2012
- Author(s)
  Shigenaga, A.; Hirakawa, H.; Yamamoto, J.; Ogura, K.; Denda, M.; Yamaguchi, K.; Otaka, A
- Journal Title
  
  Peptide Science 2011
  
  Pages: 385-386
- NAID
  10030204614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031
[Journal Article] Fmoc-based solid-phase synthesis of adenylylated peptides using diester-type adenylylated amino acid derivatives2012
- Author(s)
  Ogura, K.; Shigenaga, A.; Ebisuno, K.; Hirakawa, H.; Otaka, A
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: (in press) Pages: 3429-3432
- DOI
  10.1016/j.tetlet.2012.04.063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031, KAKENHI-PROJECT-22790012, KAKENHI-PROJECT-23390026, KAKENHI-PROJECT-23659055, KAKENHI-PROJECT-24390026, KAKENHI-PUBLICLY-23107523, KAKENHI-PUBLICLY-24102521
[Journal Article] Development of Organic and Bio-organic Methodologies for the Synthesis of Proteins2012
- Author(s)
  大高　章
- Journal Title
  
  J. Syn. Org. Chem., Jpn.
  
  Volume: 70 Issue: 10 Pages: 1054-1054
- DOI
  10.5059/yukigoseikyokaishi.70.1054
- NAID
  10031124010
- ISSN
  0037-9980, 1883-6526
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390026, KAKENHI-PROJECT-23659055, KAKENHI-PROJECT-24390026, KAKENHI-PUBLICLY-24102521
[Journal Article] Development of a Reduction-Responsive Amino Acid that Induces Peptide Bond Cleavage in Hypoxic Cells2012
- Author(s)
  Shigenaga, A., et al.
- Journal Title
  
  ChemBioChem.
  
  Volume: 13 Pages: 968-971
- DOI
  10.1002/cbic.201200141
- NAID
  120006493361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J08406, KAKENHI-PROJECT-21390031, KAKENHI-PROJECT-22790012, KAKENHI-PROJECT-23390026, KAKENHI-PROJECT-23659055, KAKENHI-PROJECT-24390026, KAKENHI-PUBLICLY-24102521
[Journal Article] Development of UV-responsive catch-andrelease system of a cysteine protease model peptide2011
- Author(s)
  Shigenaga, A.; Morishita, K.; Yamaguchi, K.; Ding, H.; Ebisuno, K.; Sato, K.; Yamamoto, J.; Akaji, K.; Otaka, A
- Journal Title
  
  Tetrahedron
  
  Volume: 67 Pages: 8879-8886
- DOI
  10.1016/j.tet.2011.09.062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031, KAKENHI-PROJECT-22790012, KAKENHI-PUBLICLY-23107523, KAKENHI-PROJECT-23390026, KAKENHI-PROJECT-23659055
[Journal Article] Synthesis of CXCL14 and its derivatives utilizing C to N or N to C directive sequential NCL protocol2011
- Author(s)
  Tsuji, K.; Sumikawa, Y.; Tanegashima, K.; Shigenaga, A.; Hara, T.; Otaka, A
- Journal Title
  
  Biopolymers
  
  Volume: 96 Pages: 447-447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659055
[Journal Article] Synthesis of nonhydrolyzable AMPylated amino acid analogues for uncovering the physiological role of AMPylation2011
- Author(s)
  Ogura, K.; Hirakawa, H.; Shigenaga, A.; Otaka, A
- Journal Title
  
  Peptide Science 2010
  
  Pages: 205-205
- NAID
  10028237863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031
[Journal Article] N-Sulfanylethylanilide Peptide as a Crypto-Thioester Peptide2011
- Author(s)
  Sato, K.; Shigenaga, A.; Tsuji, K.; Tsuda, S.; Sumikawa, Y.; Sakamoto, K.; Otaka, A
- Journal Title
  
  ChemBioChem
  
  Volume: 12 Pages: 1840-1844
- DOI
  10.1002/cbic.201100241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031, KAKENHI-PROJECT-22790012, KAKENHI-PUBLICLY-23107523, KAKENHI-PROJECT-23390026, KAKENHI-PROJECT-23659055
[Journal Article] Native chemical ligation using N-peptidyl anilide as crypto-thioester2011
- Author(s)
  Sato, K.; Tsuda, S.; Maeda, N.; Denda, M.; Shigenaga, A.; Otaka, A
- Journal Title
  
  Peptide Science 2010
  
  Pages: 203-203
- NAID
  10028237853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031
[Journal Article] Development of stimulus responsive thiol releasing system for controlling activity of cysteine protease2011
- Author(s)
  Morishita, K.; Yamaguchi, K.; Ding, H.; Shigenaga, A.; Akaji, K.; Otaka, A
- Journal Title
  
  Peptide Science 2010
  
  Pages: 290-290
- NAID
  10028238228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031
[Journal Article] Development of amide bond cleavage device with application to chemical biology use2011
- Author(s)
  Otaka, A.; Shigenaga, A
- Journal Title
  
  Peptide Science 2010
  
  Pages: 49-49
- NAID
  10028237182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031
[Journal Article] Design and Synthesis of Traceable Linker for Efficient Enrichment and Specific Labeling of Target Proteins2011
- Author(s)
  Yamamoto, J.; Tanaka, T.; Denda, M.; Shigenaga, A.; Nomura, W.; Tamamura, H.; Otaka, A
- Journal Title
  
  Biopolymers
  
  Volume: 96 Pages: 492-492
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659055
[Journal Article] Dual Kinetically Controlled Native Chemical Ligation Using a Combination of Sulfanylproline and Sulfanylethylanilide Peptide2011
- Author(s)
  Ding, H.; Shigenaga, A.; Sato, K.; Morishita, K.; Otaka, A
- Journal Title
  
  Org. Lett.
  
  Volume: 13 Pages: 5588-5591
- DOI
  10.1021/ol202316v
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031, KAKENHI-PROJECT-22790012, KAKENHI-PUBLICLY-23107523, KAKENHI-PROJECT-23659055
[Journal Article] N-Sulfanylethyl-anilide derivative as a peptide thioester equivalent2011
- Author(s)
  Sato, K.; Tsuda, S.; Tsuji, K.; Sakamoto, K.; Shigenaga, A.; Otaka, A
- Journal Title
  
  Proceedings of the Twenty-Second American Peptide Symposium
  
  Pages: 72-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031
[Journal Article] N-sulfanylethylanilide derivative as a peptide thioester equivalent2011
- Author(s)
  Sato, K.; Tsuda, S.; Tsuji, K.; Sakamoto, K.; Shigenaga, A.; Otaka, A
- Journal Title
  
  Biopolymers
  
  Volume: 96 Pages: 445-445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659055
[Journal Article] Application of N to C- or C to N-directed sequential native chemical ligation to the preparation of CXCL14 analogs and their biological evaluation.2011
- Author(s)
  Tsuji, K.; Shigenaga, A.; Sumikawa, Y.; Tanegashima, K.; Sato, K.; Aihara, K.; Hara, T.; Otaka, A
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 19 Pages: 4014-4020
- DOI
  10.1016/j.bmc.2011.05.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031, KAKENHI-PROJECT-22790012, KAKENHI-PUBLICLY-23107523, KAKENHI-PROJECT-23390026, KAKENHI-PROJECT-23659055, KAKENHI-PROJECT-23659481
[Journal Article] Enantioselective synthesis of stimulus-responsive amino acid via pyrrolidinyl tetrazole catalyzed asymmetricα-amination of aldehyde2011
- Author(s)
  Shigenaga, A.; Yamamoto, J.; Nishioka, N.; Denda, M.; Otaka, A
- Journal Title
  
  Peptide Science 2010
  
  Pages: 202-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031
[Journal Article] Synthesis of CXCL14 and its derivatives utilizing C to N or N to C directive sequential NCL protocol2011
- Author(s)
  Tsuji, K.; Sumikawa, Y.; Tanegashima, K.; Shigenaga, A.; Hara, T.; Otaka, A
- Journal Title
  
  Proceedings of the Twenty-Second American Peptide Symposium
  
  Pages: 74-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031
[Journal Article] Design and synthesis of caged ceramide : UV-responsive ceramide releasing system based on UV-induced amide bond cleavage followed by O-N acyl transfer2011
- Author(s)
  Shigenaga, A.; Hirakawa, H.; Yamamoto, J.; Ogura, K.; Denda, M.; Yamaguchi, K.; Tsuji, D.; Itoh, K.; Otaka, A
- Journal Title
  
  Tetrahedron
  
  Volume: 67 Pages: 3984-3990
- DOI
  10.1016/j.tet.2011.04.048
- NAID
  120006493357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031, KAKENHI-PROJECT-22790012, KAKENHI-PUBLICLY-23107523, KAKENHI-PROJECT-23390026
[Journal Article] Design and synthesis of caged ceramide: UV-responsive ceramide releasing system based on UV-induced amide bond cleavage followed by O-N acyl transfer2011
- Author(s)
  Shigenaga, A.; Hirakawa, H.; Yamamoto, J.; Ogura, K.; Denda, M.; Yamaguchi, K.; Tsuji, D.; Itoh, K.; Otaka, A
- Journal Title
  
  Tetrahedron
  
  Volume: 67 Pages: 3984-3990
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659055
[Journal Article] Synthesis and biological evaluation of CXCL14 and its derivatives2011
- Author(s)
  Tsuji, K.; Sumikawa, Y.; Tanegashima, K.; Shigenaga, A.; Hara, T.; Otaka, A
- Journal Title
  
  Peptide Science 2010
  
  Pages: 182-182
- NAID
  10028237759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031
[Journal Article] Development of recapturable cleavable linker for efficient enrichment and specific labeling of target proteins2011
- Author(s)
  Yamamoto, J.; Maeda, N.; Denda, M.; Shigenaga, A.; Otaka, A
- Journal Title
  
  Peptide Science 2010
  
  Pages: 232-232
- NAID
  10028237977
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031
[Journal Article] Sequential native chemical ligation utilizing peptide thioacids derived from newly developed Fmoc-based synthetic method2010
- Author(s)
  Shigenaga, A.; Sumikawa, Y.; Tsuda, S.; Sato, K.; Otaka, A
- Journal Title
  
  Tetrahedron
  
  Volume: 66 Pages: 3290-3296
- DOI
  10.1016/j.tet.2010.03.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031
[Journal Article] Proline cis/ trans-Isomerase Pin1 Regulates Peroxisome Proliferator-activated Receptor gamma Activity through the Direct Binding to the Activation Function-1 Domain2010
- Author(s)
  Fujimoto, Y.; Shiraki, T.; Horiuchi, Y.; Waku, T.; Shigenaga, A.; Otaka, A.; Ikura, T.; Igarashi, K.; Aimoto, S.; Tate, S.; Morikawa, K
- Journal Title
  
  J. Biol. Chem
  
  Volume: 285 Pages: 3126-3132
- DOI
  10.1074/jbc.m109.055095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031
[Journal Article] Development of thiol-responsive amide bond cleavage device and its application for peptide nucleic acid-based DNA releasing system2010
- Author(s)
  Shigenaga, A.; Yamamoto, J.; Hirakawa, H.; Ogura, K.; Maeda, N.; Morishita, K.; Otaka, A
- Journal Title
  
  Tetrahedron Lett
  
  Volume: 51 Pages: 2525-2528
- DOI
  10.1016/j.tetlet.2010.03.006
- NAID
  120006493352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031
[Journal Article] Enantioselective synthesis of stimulus-responsive amino acid via asymmetricα-amination of aldehyde2010
- Author(s)
  Shigenaga, A.; Yamamoto, J.; Nishioka, N.; Otaka, A
- Journal Title
  
  Tetrahedron
  
  Volume: 66 Pages: 7367-7372
- DOI
  10.1016/j.tet.2010.07.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031, KAKENHI-PROJECT-22790012
[Journal Article] Development of amide bond cleavage device with application to chemical biology use2010
- Author(s)
  Otaka, A.
- Journal Title
  
  Peptide Science 2010
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031
[Journal Article] A structure-activity relationship study elucidating the mechanism of sequence-specific collagen recognition by the chaperone HSP472010
- Author(s)
  Nishikawa, Y.; Takahara, Y.; Asada, S.; Shigenaga, A.; Otaka, A.; Kitagawa, K.; Koide, T
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 18 Pages: 3767-3775
- DOI
  10.1016/j.bmc.2010.04.054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031
[Journal Article] Recent Progress in the Synthetic Methodologies of Peptide Thioesters2010
- Author(s)
  Shigenaga, A.; Sato, K.; Otaka, A
- Journal Title
  
  J. Syn. Org. Chem., Jpn.
  
  Volume: 68 Issue: 9 Pages: 911-919
- DOI
  10.5059/yukigoseikyokaishi.68.911
- NAID
  10026870593
- ISSN
  0037-9980, 1883-6526
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031
[Journal Article] N-> S Acyl-Transfer-Mediated Synthesis of Peptide Thioesters Using Anilide Derivatives2009
- Author(s)
  Tsuda, S.; Shigenaga, A.; Bando, K.; Otaka, A
- Journal Title
  
  Org. Lett
  
  Volume: 11 Pages: 823-826
- DOI
  10.1021/ol8028093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031
[Journal Article] Synthesis of Fluoroalkene Dipeptide Isosteres by an Intramolecular Redox Reaction Utilizing N-Heteorocyclic Carbenes(NHCs)2009
- Author(s)
  Yamaki, Y.; Shigenaga, A.; Tomita, K.; Narumi, T.; Fujii, N.; Otaka, A
- Journal Title
  
  J. Org. Chem
  
  Volume: 74 Pages: 3272-3277
- DOI
  10.1021/jo900134k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031
[Journal Article] Synthesis of Amide-type Fluoroalkene Dipeptide Isosteres by Intramolecular Redox Reaction2009
- Author(s)
  Y. Yamaki, A. Shigenaga, J. Li, Y. Shimohigashi, A. Otaka
- Journal Title
  
  J. Org. Chem 74
  
  Pages: 3278-3285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390006
[Journal Article] N-S acyl-transfer-mediated synthesis of peptide thioesters using anilide derivatives2009
- Author(s)
  S. Tsuda, A. Shigenaga, K. Bandoh, A. Otaka
- Journal Title
  
  Org. Lett 11
  
  Pages: 823-826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390006
[Journal Article] Synthesis of Fluoroalkene Dipeptide Isosteres by Intramolecular Redox Reaction Utilizing N-Heteorocyclic Carbenes(NHCs)2009
- Author(s)
  Y. Yamaki, A. Shigenaga, K. Tomita, T. Narumi, N. Fujii, A. Otaka
- Journal Title
  
  J. Org. Chew 74
  
  Pages: 3272-3277
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390006
[Journal Article] FRET-based assay of the processing reaction kinetics of stimulus-responsive peptides : influence of amino acid sequence on reaction kinetics2009
- Author(s)
  A. Shigenaga, J. Yamamoto, H. Hirakawa, K. Yamaguchi, A. Otaka
- Journal Title
  
  Tetrahedron 65
  
  Pages: 2212-2216
- NAID
  120006493353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390006
[Journal Article] Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 12009
- Author(s)
  Yun, S. M.; Moulaei, T.; Lim, D.; Bang, J. K.; Park, J. E.; Shenoy, S. R.; Liu, F.; Kang, Y. H.; Liao, C. Z.; Soung, N. K.; Lee, S.; Yoon, D. Y.; Lim, Y.; Lee, D. H.; Otaka, A.; Appella, E.; McMahon, J. B.; Nicklaus, M. C.; Burke, T. R.; Yaffe, M. B.; Wlodawer, A.; Lee, K. S.
- Journal Title
  
  Nature Structural & Molecular Biology
  
  Volume: 16 Pages: 876-882
- DOI
  10.1038/nsmb.1628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031
[Journal Article] Electrostatically constrained a-helical peptide inhibits replication of HIV-1 resistant to Enfuvirtide2009
- Author(s)
  H. Nishikawa, S. Nakamura, E. Kodama, S. Ito, K. Kajiwara, K. Izumi, Y. Sakagami, S. Oishi, T. Ohkubo, Y. Kobayashi, A. Otaka, N. Fujii, and M. Matsuoka
- Journal Title
  
  Int. J. Cell. Biol 41
  
  Pages: 891-899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390006
[Journal Article] Synthesis of Amide-Type Fluoroalkene Dipeptide Isosteres by an Intramolecular Redox Reaction2009
- Author(s)
  Yamaki, Y.; Shigenaga, A.; Li, J. L.; Shimohigashi, Y.; Otaka, A
- Journal Title
  
  J. Org. Chem
  
  Volume: 74 Pages: 3278-3285
- DOI
  10.1021/jo900135t
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031
[Journal Article] FRET-based assay of the processing reaction kinetics of stimulus-responsive peptides : influence of amino acid sequence on reaction kinetics2009
- Author(s)
  Shigenaga, A.; Yamamoto, J.; Hirakawa, H.; Yamaguchi, K.; Otaka, A
- Journal Title
  
  Tetrahedron
  
  Volume: 65 Pages: 2212-2216
- DOI
  10.1016/j.tet.2009.01.013
- NAID
  120006493353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390031
[Journal Article] Heptad Repeat-Derived Peptides Block Protease-Mediated Direct Entry from the Cell Surface of Severe Acute Respiratory Syndrome Coronavirus but Not Entry via the Endosomal Pathway2008
- Author(s)
  M. Ujike, H. Nishikawa, A. Otaka, N. Yamamoto, N. Yamamoto, M. Matsuoka, E. Kodama, N. Fujii, and F. Taguchi
- Journal Title
  
  J. Virology 82
  
  Pages: 588-592
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390006
[Journal Article] Identification of minimal sequence for HIV-1 fusion inhibitors2008
- Author(s)
  H. Nishikawa, S. Oishi, M. Fujita, K. Watanabe, R. Tokiwa, H. Ohno, E. Kodama, K. Izumi, K. Kajiwara, T. Naitoh, M. Matsuoka, A. Otaka, and N. Fujii
- Journal Title
  
  Bioorg. Med. Chem 20
  
  Pages: 9184-9187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390006
[Journal Article] Synthesis of a nucleocytoplasmic shuttle peptide possessing a stimulus-responsive amino acid2008
- Author(s)
  A. Shigenaga, D. Tsuji, N. Nishioka, S. Tsuda, K. Itoh and A. Otaka
- Journal Title
  
  Chemical Biology 1
  
  Pages: 7-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390006
[Journal Article] Synthesis of (Z)-alkene-containing cis-proline dipeptide mimetics using amarium(II) diiodide (SmI_2)-mediated reductive alkylation reaction2007
- Author(s)
  Y. Sasaki, A. Shigenaga, N. Fujii and A. Otaka
- Journal Title
  
  Tetrahedron 63
  
  Pages: 2000-2008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390006
[Journal Article] Synthesis of a stimulus-responsive processing device and its application to a nucleocytoplasmic shuttle peptide2007
- Author(s)
  A. Shigenaga, D. Tsuji, N. Nishioka, S. Tsuda, K. Itoh and A. Otaka
- Journal Title
  
  Chem Bio Chem 8
  
  Pages: 1929-1931
- NAID
  120006493351
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390006
[Journal Article] Development of copper-mediated allylation of γ-activated-α,113-unsaturated lactam toward peptide mimetic synthesis2007
- Author(s)
  Y. Sasaki, K. Yamaguchi, T. Tsuji, A. Shigenaga, N. Fujii and A. Otaka
- Journal Title
  
  Tetrahedron Lett 48
  
  Pages: 3221-3224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390006
[Journal Article] α2 Isoform-specific activation of 5'adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-β-D-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle2006
- Author(s)
  M. Nakano, T. Hamada, T. Hayashi, S. Yonemitsu, L. Miyamoto, T. Toyoda, S. Tanaka, H. Masuzaki, K. Ebihara, Y. Ogawa, K. Hosoda, G. Inoue, Y. Yoshimasa, A. Otaka, T. Fushiki, and K. Nakao
- Journal Title
  
  Metab. Clinic. Experiment 55
  
  Pages: 300-308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390006
[Journal Article] Stereoselective Synthesis of(Z)-Alkene-Containing Proline Dipeptide Mimetics2006
- Author(s)
  Y. Sasaki, A. Niida, T. Tsuji, A. Shigenaga, N. Fujii, and A. Otaka
- Journal Title
  
  J. Org. Chem 71
  
  Pages: 4969-4979
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390006
[Journal Article] Synthesis of(Z)-Alkene and(E)-Fluoroalkene-Containing Diketopiperazine Mimetics Utilizing Oraganocopper-Mediated Reduction-Alkylation and Diastereoseleetivity Examination Using DFT Calculations2006
- Author(s)
  A. Niida, M. Mizumoto, T. Narumi, E. Inokuehi, S. Oishi, H. Ohno, A. Otaka, K. Kitaura, and N. Fujii
- Journal Title
  
  J. Org. Chem 71
  
  Pages: 4118-4129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390006
[Journal Article] A novel one-pot reaction involving organocopper-mediated reduction/transmetalation/asymmetric alkylation, leading to the diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres2006
- Author(s)
  T. Narumi, A. Niida, K. Tomita, S. Oishi, A. Otaka, H. Ohno and N. Fujii
- Journal Title
  
  Chem. Commun 45
  
  Pages: 4720-4722
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390006
[Journal Article] Stereoselective Synthesis of 3,6-Disubstituted-3,6-dihydropyridin-2-ones as Potential Diketopiperazine Mimetics Using Organocopper-Mediated anti-SN2'Reactions and Their Use in the Preparation of Low-Molecule CXCR4 Antagonists2006
- Author(s)
  Niida, H. Tanigaki, E. Inokuchi, Y. Sasaki, S. Oishi, H. Ohno, H. Tamamura, Z. Wang, S. C. Peiper, K. Kitaura, A. Otaka, and N. Fujii
- Journal Title
  
  A. J. Org. Chem 71
  
  Pages: 3942-3951
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390006
[Journal Article] Unequivocal Synthesis of (Z)-Alkene and (E)-Fluoroalkene Dipeptide Isosters to Probe Structural Requirements of Peptide Transporter PEPTI2006
- Author(s)
  A. Niida, K, Tomita, M. Mizuinoto, H. Tanigaki, T. Terada, S. Oishi, A. Otaka, K. Inui, and N. Fujii
- Journal Title
  
  Org. Lett 8
  
  Pages: 613-616
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390006
[Journal Article] Specific recognition of the collagen triple helix by chaperone HSP47. II. The HSP47-binding structural motif in collagens and related proteins2006
- Author(s)
  T. Koide, Y. Nishikawa, S. Asada, C. M. Yamazaki, Y. Takahara, D. L. Homma, A. Otaka, K. Ohtani, N. Wakamiya, K. Nagata, and K. Kitagawa
- Journal Title
  
  J. Biol. Chem 281
  
  Pages: 11177-11185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390006
[Journal Article] Cysteine-derived S-Protected Oxazolidinones : Potential Chemical. Devices for the Preparation of Peptide Thioesters2006
- Author(s)
  Y. Ohta, S. Itch, A. Shigenaga, S. Shintaku, N. Fujii, and A. Otaka
- Journal Title
  
  Org. Lett 8
  
  Pages: 467-470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390006
[Journal Article] Sml_2-Mediated Reduction of γ,γ-Difluoro-α,β-enoates with Application to the Synthesis of Functionalized(Z)-Fluoroalkene-Type Dipeptide Isosteres.2004
- Author(s)
  Akira Otaka et al.
- Journal Title
  
  J.Org.Chem. 69
  
  Pages: 1634-1645
- Data Source
  KAKENHI-PROJECT-15659026
[Journal Article] Facile Synthesis of Membrane-embedded Peptides Utilizing Lipid Bilayer-assisted Chemical Ligation.2004
- Author(s)
  A.Otaka
- Journal Title
  
  Chem. Commun.
  
  Pages: 1722-1723
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390037
[Journal Article] SmI2-mediated Reduction of γ,γ-Difluoro-_α,β-enoates and Its Application to the Synthesis of (Z)-Fluoroalkene-type Dipeptide Isosteres2004
- Author(s)
  A.Otaka, J.Watanabe, N.Fujii, et al.
- Journal Title
  
  J.Org.Chem. 69
  
  Pages: 1634-1645
- Data Source
  KAKENHI-PROJECT-14207099
[Journal Article] Facile synthesis of membrane-embedded peptides utilizing lipid bilayer-assisted chemical ligation.2004
- Author(s)
  Akira Otaka et al.
- Journal Title
  
  Chem.Commun. 2004
  
  Pages: 1722-1723
- Data Source
  KAKENHI-PROJECT-15659026
[Journal Article] Facile Synthesis of Membrane-embedded Peptides Utilizing Lipid Bilayer-assisted Chemical Ligation.2004
- Author(s)
  A.Otaka, S.Ueda, N.Fujii, et al.
- Journal Title
  
  Chem.Commun. 7
  
  Pages: 1722-1723
- Data Source
  KAKENHI-PROJECT-14207099
[Journal Article] Facile Synthesis of Membrane-embedded Peptides Utilizing Lipid Bilayer-assisted Chemical Ligation.2004
- Author(s)
  A.Otaka, et al.
- Journal Title
  
  Chem.Commun. 7(15)
  
  Pages: 1722-1723
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207099
[Journal Article] Facile synthesis of membrane-embedded peptides utilizing lipid bilayer-assisted chemical ligation.2004
- Author(s)
  Akira Otaka et al.
- Journal Title
  
  Chem.Commun. 2004
  
  Pages: 1722-1723
- Data Source
  KAKENHI-PROJECT-15390037
[Journal Article] Synthesis of fluorine-containing Bioisosteres corresponding to phosphoamino acids and dipeptide units.2004
- Author(s)
  Akira Otaka et al.
- Journal Title
  
  Biopolymers 76
  
  Pages: 140-149
- Data Source
  KAKENHI-PROJECT-15659026
[Journal Article] Synthesis of Fluorine-Containing Bioisosteres Corresponding to Phosphoamino Acids and Dipeptide Units2004
- Author(s)
  A.Otaka, E.Mitsuyama, N.Fujii, et al.
- Journal Title
  
  Biopolymers 76
  
  Pages: 140-149
- Data Source
  KAKENHI-PROJECT-14207099
[Journal Article] Synthesis of fluorine-containing Bioisosteres corresponding to phosphoamino acids and dipeptide units.2004
- Author(s)
  Akira Otaka et al.
- Journal Title
  
  Biopolymers 76
  
  Pages: 140-149
- Data Source
  KAKENHI-PROJECT-15390037
[Journal Article] SmI_2-Mediated Reduction of γ,γ-Difluoro-α,β-enoates with Application to the Synthesis of Functionalized (Z)-Fluoroalkene-Type Dipeptide Isosteres.2004
- Author(s)
  A.Otaka
- Journal Title
  
  J. Org. Chem. 69
  
  Pages: 1634-1645
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390037
[Journal Article] SmI_2-Mediated Reduction of γ,γ-Difluoro-α,β-enoates with Application to the Synthesis of Functionalized(Z)-Fluoroalkene-Type Dipeptide Isosteres.2004
- Author(s)
  Akira Otaka et al.
- Journal Title
  
  J.Org.Chem. 69
  
  Pages: 1634-1645
- Data Source
  KAKENHI-PROJECT-15390037
[Journal Article] Facile Synthesis of Membrane-embedded Peptides Utilizing Lipid Bilayer-assisted Chemical Ligation.2004
- Author(s)
  A.Otaka, et al.
- Journal Title
  
  Chem.Commun. 7
  
  Pages: 1722-1723
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207099
[Journal Article] Facile Synthesis of Membrane-embedded Peptides Utilizing Lipid Bilayer-assisted Chemical Ligation.2004
- Author(s)
  A.Otaka
- Journal Title
  
  Chem.Commun.
  
  Pages: 1722-1723
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390037
[Journal Article] SmI_2-Mediated Reduction of γ,γ-Difluoro-α,β-enoates with Application to the Synthesis of Functionalized (Z)-Fluoroalkene-Type Dipeptide Isosteres.2004
- Author(s)
  A.Otaka
- Journal Title
  
  J.Org.Chem. 69
  
  Pages: 1634-1645
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390037
[Journal Article] Synthesis of Fluorine-containing Bioisosteres Corresponding to Phosphoamino Acids and Dipeptide Units.2004
- Author(s)
  A.Otaka
- Journal Title
  
  Biopolymers 76
  
  Pages: 140-149
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390037
[Journal Article] Application of Samarium Diiodide (SmI_2)-induced Reduction of γ-Acetoxy-α,β-enoates with α-Specific Kinetic Electrophilic Trapping for the Synthesis of Amino Acid Derivatives.2003
- Author(s)
  A.Otaka
- Journal Title
  
  Chem.Commun.
  
  Pages: 1834-1835
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390037
[Journal Article] Application of Samarium Diiodide (SmI_2)-induced Reduction of γ-Acetoxy-α,β-enoates with α-Specific Kinetic Electrophilic Trapping for the Synthesis of Amino Acid Derivatives2003
- Author(s)
  A.Otaka
- Journal Title
  
  Chem. Commun.
  
  Pages: 1834-1835
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390037
[Presentation] Development of acyl transfer-based chemical biology tools for purification/selective labeling of target proteins.2019
- Author(s)
  Shigenaga, A.; Morisaki, T.; Kohiki, T.; Denda, M.; Inokuma, T.; Otaka, A.
- Organizer
  5th International Symposium for Medicinal Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19492
[Presentation] Development of methodology for cyclic peptide synthesis using a thiol-incorporated DMAP catalyst.2018
- Author(s)
  Ohkawachi, K.; Morimoto, K.; Naruse, N.; Yamatsugu, K.; Shigenaga, A.; Kanai, M.; Otaka, A.
- Organizer
  10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] CpG DNA/CXCL14複合体に対する候補受容体の発現クローニング2018
- Author(s)
  三井貴洋、種子島幸祐、成瀬公人、重永　章、大髙　章、原　孝彦
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] Development of anti-cancer peptide based on prohibitin 2.2018
- Author(s)
  Anyohji, K.; Aihara, K.; Yoshimaru, T.; Shigenaga, A.; Katagiri, T.; Otaka,A.
- Organizer
  10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] On-resinチオエステル化法から得られた知見とその応用2018
- Author(s)
  成瀬公人、大川内健人、猪熊翼、重永章、大髙章
- Organizer
  第50回若手ペプチド夏の勉強会
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] 新規チオール触媒を利用した環状ペプチド合成法の開発2018
- Author(s)
  大川内健人、成瀬公人、重永章、大髙章
- Organizer
  創薬懇話会 2018 in 志賀島
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] 発現タンパク質に適用可能な新規チオエステル合成法の開発2018
- Author(s)
  小宮千明、月本準、上田将弘、森崎巧也、猪熊翼、重永章、伊藤孝司、大髙章
- Organizer
  創薬懇話会 2018 in 志賀島
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] 人工HDLの化学的性状と体内動態への影響に関する検討2018
- Author(s)
  金山忠史、奥平桂一郎、大川内健人、清水太郎、重永　章、大髙　章、石田竜弘
- Organizer
  第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-17K19492
[Presentation] ペプチドイミンに対する不斉1,2-付加を基盤とする非天然アミノ酸含有ペプチドの不斉合成2018
- Author(s)
  猪熊　翼、岡田和貴、西田航大、重永　章、大髙　章、山田健一
- Organizer
  第44回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-17K19492
[Presentation] SECmideを基盤としたターンオン型蛍光クリーバブルリンカーの開発2018
- Author(s)
  森崎巧也、重永　章、大髙　章
- Organizer
  第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-17K19492
[Presentation] 新規チオール触媒を利用した分子内ライゲーション法の開発2018
- Author(s)
  大川内健人、森本恭平、成瀬公人、重永章、金井求、大髙章
- Organizer
  第50回若手ペプチド夏の勉強会
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] がん抑制タンパク質PHB2からの創薬シード発掘2018
- Author(s)
  安養寺啓太央、粟飯原圭祐、吉丸哲郎、重永章、片桐豊雅、大髙章
- Organizer
  第50回若手ペプチド夏の勉強会
- Data Source
  KAKENHI-PROJECT-17K19492
[Presentation] 均一修飾タンパク質の合成を施行したタンパク質C末端特異的活性化反応の開発2018
- Author(s)
  小宮千明、月本　準、森崎巧也、津田雄介、宮島　凜、猪熊　翼、重永　章、伊藤孝司、大髙　章
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] CXCL14とCpG DNAの相互作用によるTLR9活性化の特異性と責任領域の解析2018
- Author(s)
  岩瀬璃奈、成瀬公人、種子島幸祐、重永　章、大髙　章、原　孝彦
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] 酵素を利用したチオエステル調製のためのC末ペプチド配列の最適化2018
- Author(s)
  上田将弘、小宮千明、重永章、大髙章
- Organizer
  第50回若手ペプチド夏の勉強会
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] Development and application of novel protein labeling reagent SEAL.2018
- Author(s)
  Kohiki, T.; Kato, Y.; Denda, M.; Nishikawa, Y.; YORITA, K.; Sagawa, I.; Inokuma, T.; Shigenaga, A.; Fukui, K.; Otaka, A.
- Organizer
  10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19492
[Presentation] Combined approach of computation and enzymology to investigate novel D-amino acid oxidase inhibitors.2018
- Author(s)
  Kato, Y.; Maita, N.; Kohiki, T.; Kurosawa, S.; Nishikawa, Y.; Sagawa, I.; Denda, M.; Inokuma, T.; Shishido, Y.; YORITA, K.; Shigenaga, A.; Otaka, A.; Fukui, K.
- Organizer
  The 13th International Symposium of the Institute Network for Biomedical Sciences joint with the 3rd Symposium of the Inter-University Research Network for Trans-Omics Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19492
[Presentation] 加水分解酵素を利用したC末端特異的チオエステル化反応の開発2018
- Author(s)
  小宮千明、月本準、上田将弘、森崎巧也、猪熊翼、重永章、伊藤孝司、大髙章
- Organizer
  第50回若手ペプチド夏の勉強会
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] Preparation of protein thioesters enabled by carboxypeptidase-mediated C-terminal specific hydrazinolysis.2018
- Author(s)
  Komiya, C.; Tsukimoto, J.; Ueda, M.; Morisaki, T.; Inokuma, T.; Shigenaga, A.; Itou, K.; Otaka, A.
- Organizer
  10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] S-アデノシルホモシステイン加水分解酵素の蛍光性基質の開発2018
- Author(s)
  中西雅之、古曳泰規、重永　章、大髙　章、田中信忠、北出幸夫、日野真美、野元　裕
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K19492
[Presentation] Development of method for deprotection of N-terminal thiazolidine derivative using copper salt for chemical protein synthesis.2018
- Author(s)
  Naruse, N.; Matsumoto, K.; Shigenaga, A.; Otaka, A.
- Organizer
  10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] 安定なイミンを用いたα-アミノリン酸の実用的不斉合成2018
- Author(s)
  榊原拓哉、猪熊翼、重永章、大髙章、山田健一
- Organizer
  創薬懇話会 2018 in 志賀島
- Data Source
  KAKENHI-PROJECT-17K19492
[Presentation] N-Sアシル基転移速度の向上を指向した新規補助基の開発2018
- Author(s)
  河野誉良、成瀬公人、猪熊翼、重永章、大髙章
- Organizer
  第50回若手ペプチド夏の勉強会
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] アシル基転移反応を基盤とする標的タンパク質精製・機能解明ツールの開発2018
- Author(s)
  重永　章、大高　章
- Organizer
  日本薬学会第１３８年会（シンポジウム中分子創薬研究のフロンティア）
- Invited
- Data Source
  KAKENHI-PROJECT-15K07858
[Presentation] Novel methodology for the synthesis of-indolyl-glycine containing peptidevia direct asymmetric FriedelCrafts reactionto peptidyl imine.2018
- Author(s)
  Inokuma, T.; Nishida, K.; Shigenaga, A.; Yamada, K.; Otaka, A.
- Organizer
  35th European Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19492
[Presentation] トレーサブルリンカーを用いた共有結合性低分子の標的同定2018
- Author(s)
  森崎巧也、中山淳、難波康祐、重永章、大髙章
- Organizer
  第50回若手ペプチド夏の勉強会
- Data Source
  KAKENHI-PROJECT-17K19492
[Presentation] 酵素を利用したチオエステル化反応の効率化を指向したペプチドC末配列の修飾2018
- Author(s)
  上田将弘、小宮千明、重永　章、大髙　章
- Organizer
  第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] 非天然側鎖構造を有するα-アミノリン酸の実用的不斉合成2018
- Author(s)
  榊原拓哉、猪熊　翼、重永　章、大髙　章、山田健一
- Organizer
  第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-17K19492
[Presentation] チオエステル等価体ユニットを利用した環状ペプチド効率的合成法の開発2017
- Author(s)
  寺中孝久、粟飯原圭佑、山岡浩輔、猪熊　翼、重永　章、大髙　章
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] アルギニンペプチドのグリコサミノグリカン糖鎖を介した細胞膜透過機構に関する物理化学的解析2017
- Author(s)
  灘井亮，原矢佑樹，西辻和親，内村健治，加藤くみ子，重永章，川上徹，大高章，北條裕信，坂下直実，斎藤博幸
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-25293006
[Presentation] N-Sアシル基転移を基盤としたタンパク質ラベル化法を用いたD-アミノ酸酸化酵素阻害剤の結合サイト解明研究2017
- Author(s)
  古曳泰規、加藤有介、西川祐輔、頼田和子、佐川幾子、傳田将也、猪熊　翼、重永　章、福井　清、大髙　章
- Organizer
  第56回日本薬学会・日本薬剤師会・日本大学病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-17K19492
[Presentation] タンパク質C末端特異的活性化反応の開発2017
- Author(s)
  小宮千明、津田雄介、宮島　凜、猪熊　翼、重永　章、大髙　章
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] チオエステル等価体として機能するタンパク質の化学合成のための新規補助基の開発2017
- Author(s)
  河野誉良、成瀬公人、猪熊　翼、重永　章、大髙　章
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター、東北大学川内地区（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] DAO分子表面に結合する阻害分子の計算科学的解析2017
- Author(s)
  加藤有介、古曳泰規、西川祐輔、佐川幾子、傳田将也、猪熊　翼、宍戸裕二、重永　章、大髙　章、福井　清
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K19492
[Presentation] N-S-acyl-transfer-mediated On-resin Formation of Thioester with Practical Application to Peptide Synthesis.2017
- Author(s)
  成瀬公人、大川内健人、猪熊　翼、重永　章、伊藤孝司、大髙　章
- Organizer
  第54回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] N-Sulfanylethylanilideを用いた細胞内標的タンパク質ラベル化法の開発2017
- Author(s)
  古曳泰規、傳田将也、藤川昴樹、猪熊　翼、重永　章、小暮健太朗、大高　章
- Organizer
  日本薬学会第１３７年会
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K07858
[Presentation] Development of methodology for producing thioesters from naturally occurring peptide sequence.2017
- Author(s)
  小宮千明、月本　準、森崎巧也、津田雄介、宮島　凜、猪熊　翼、重永　章、伊藤孝司、大髙　章
- Organizer
  第54回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] ペプチド創薬を指向した非天然アミノ酸含有ペプチドの新規効率的合成法の開発2017
- Author(s)
  西田航大、猪熊　翼、重永　章、大髙　章
- Organizer
  創薬懇話会2017 in 加賀
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] Screening of the effectors for human D-amino acid oxidase and the analyses of structure-activity relationships2017
- Author(s)
  Kazuko YORITA, Sumire Kurosawa, Yuri Yoshida, Yoshiki Kashiwada, Shigeki Sano, Akira Otaka and Kiyoshi Fukui
- Organizer
  The 19th triennial International Symposium on Flavins and Flavoproteins
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19492
[Presentation] タンパク質化学合成のための新規N-ペプチジルアニリド型補助基の開発2017
- Author(s)
  河野誉良、成瀬公人、猪熊　翼、重永　章、大髙　章
- Organizer
  創薬懇話会2017 in 加賀
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] On-resinチオエステル化を利用した環状ペプチド合成法の開発2017
- Author(s)
  大川内健人、成瀬公人、重永　章、大髙　章
- Organizer
  第56回日本薬学会・日本薬剤師会・日本大学病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] 光応答性アポリポタンパク質の開発2017
- Author(s)
  川原遥華、奥平桂一郎、宮下直樹、津田雄介、森本恭平、辻　耕平、重永　章、大髙　章、石田竜弘
- Organizer
  日本薬剤学会第32年会
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] Application of N-Sulfanylethylanilide(SEAlide) Unit to Protein Chemical Synthesis and Protein Enrichment2017
- Author(s)
  Akira Otaka
- Organizer
  American Peptide Symposium 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] Development of anti-breast cancer stapled peptides targeting BIG3-PHB2 interaction2017
- Author(s)
  Akira Otaka
- Organizer
  AIMECS 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19492
[Presentation] Development of long-lasting stapled peptides targeting BIG3-PHB2 interaction in breast cancer cells2017
- Author(s)
  Akira Otaka, Keisuke Aihara, Tetsuro Yoshimaru, Akira Shigenaga and Toyomasa Katagiri
- Organizer
  The 6th Pharmaceutical Sciences World Congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] チオエステル等価体として機能するタンパク質の化学合成のための新規補助基の開発2017
- Author(s)
  河野誉良、成瀬公人、猪熊　翼、重永　章、大髙　章
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター、東北大学川内地区（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K14979
[Presentation] Development of N-sulfanyltehylanilide (SEAlide)-based traceable linker for enrichment and selective labeling of target proteins2016
- Author(s)
  森崎巧也、傳田将也、山本　純、辻　大輔、猪熊　翼、伊藤孝司、重永　章、大高　章
- Organizer
  第５３回ペプチド討論会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-15K07858
[Presentation] “SEAL-tag”を基盤とした細胞内での標的タンパク質ラベル化法の開発2016
- Author(s)
  古曳泰規、傳田将也、森崎巧也、辻　大輔、猪熊　翼、伊藤孝司、重永　章、大高　章
- Organizer
  日本ケミカルバイオロジー学会第１１回年会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-15K07858
[Presentation] Intein-inspired Amide Bond Processing Device.2016
- Author(s)
  Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka
- Organizer
  34th European Peptide Symposium 2016 & 8th International Peptide Symposium
- Place of Presentation
  Leipzig (Germany)
- Year and Date
  2016-09-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14979
[Presentation] 光応答型チオエステル等価体を用いた多成分One-pot NCL法の開発研究2016
- Author(s)
  山岡浩輔、粟飯原圭佑、成瀬公人、猪熊　翼、重永　章、大髙　章
- Organizer
  創薬懇話会2016 in 蓼科
- Place of Presentation
  エクシブ蓼科（長野県茅野市）
- Year and Date
  2016-06-30
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] 標的タンパク質精製ツール“SEAlide-based traceable linker”の開発2016
- Author(s)
  森崎巧也、傳田将也、辻　大輔、山本　純、猪熊　翼、伊藤孝司、重永　章、大高　章
- Organizer
  日本ケミカルバイオロジー学会第１１回年会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-15K07858
[Presentation] タンパク質位置選択的修飾を指向したチオエステル調製法の開発2016
- Author(s)
  津田雄介、重永　章、辻　耕平、傳田将也、佐藤浩平、北風圭介、中村太寛、猪熊　翼、伊藤孝司、大高　章
- Organizer
  第３４回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K07858
[Presentation] 光応答性アポA-I模倣ペプチドの開発研究2016
- Author(s)
  川原遙華、奥平桂一郎、辻耕平、津田雄介、森本恭平、木村仁、假屋園大和、大村理沙、市野晨人、杉原涼、西辻和親、重永章、坂下直実、大高章、斎藤博幸
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25293006
[Presentation] Intein-inspired Amide Bond Processing Device.2016
- Author(s)
  Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka
- Organizer
  34th European Peptide Symposium 2016 & 8th International Peptide Symposium
- Place of Presentation
  Leipzig (Germany)
- Year and Date
  2016-09-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] One-pot sequential native chemical ligations using photocaged crypto-thioester2016
- Author(s)
  山岡浩輔、粟飯原圭佑、成瀬公人、猪熊　翼、重永　章、大高　章
- Organizer
  第５３回ペプチド討論会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-15K07858
[Presentation] Iowa変異型アポA-Iによる脂質膜環境下でのアミロイド線維形成2016
- Author(s)
  水口智晴、三河志穂、馬場照彦、島内寿徳、重永章、奥平桂一郎、大高章、斎藤博幸
- Organizer
  第4回日本アミロイドーシス研究会学術集会
- Place of Presentation
  KKRホテル東京（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-25293006
[Presentation] One-Pot/Sequential Native Chemical Ligation Using Photo-responsive Crypto-thioester2016
- Author(s)
  粟飯原圭佑、山岡浩輔、成瀬公人、猪熊　翼、重永　章、大高　章
- Organizer
  34th European Peptide Symposium 2016 & 8th International Peptide Symposium
- Place of Presentation
  Leipzig (German)
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07858
[Presentation] タンパク質位置選択的修飾を指向したチオエステル調製法の開発2016
- Author(s)
  津田雄介、重永　章、辻　耕平、傳田将也、佐藤浩平、北風圭介、中村太寛、猪熊　翼、伊藤孝司、大髙章
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] ペプチド化学を基盤としたケミカルバイオロジー研究のための基盤技術の開拓2016
- Author(s)
  重永　章、大高　章
- Organizer
  日本薬学会第１３６年会（シンポジウム「疾患代謝」から解明される生命現象と創薬研究への応用）
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Invited
- Data Source
  KAKENHI-PROJECT-15K07858
[Presentation] Regioselective S-Cyanylation-mediated Preparation of Peptide Thioester .2016
- Author(s)
  Akira Otaka, Rin Miyajima, Yusuke Tsuda and Akira Shigenaga.
- Organizer
  16th Akabori Conference Japanese-German Symposium on Peptide Science
- Place of Presentation
  六甲山ホテル（兵庫県神戸市）
- Year and Date
  2016-05-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] Effect of heparin on amyloid fibril formation of apoA-I fragment peptides2016
- Author(s)
  Shiho Mikawa, Chiharu Mizuguchi, Izumi Morita, Hiroyuki Oyama, Teruhiko Baba, Akira Shigenaga, Toshinori Shimanouchi, Norihiro Kobayashi, Akira Otaka, Kenichi Akaji, and Hiroyuki Saito
- Organizer
  第53回ペプチド討論会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-25293006
[Presentation] Regioselective S-Cyanylation-mediated Preparation of Peptide Thioester .2016
- Author(s)
  Akira Otaka, Rin Miyajima, Yusuke Tsuda and Akira Shigenaga.
- Organizer
  16th Akabori Conference Japanese-German Symposium on Peptide Science
- Place of Presentation
  六甲山ホテル（兵庫県神戸市）
- Year and Date
  2016-05-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14979
[Presentation] SEAlideを基盤とした標的タンパク質精製ツールの開発研究2016
- Author(s)
  森崎巧也、傳田将也、辻　大輔、山本　純、猪熊　翼、伊藤孝司、重永　章、大高　章
- Organizer
  第３４回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K07858
[Presentation] Intein-inspired Amide Bond Processing Device2016
- Author(s)
  小宮千明、粟飯原圭佑、猪熊　翼、重永　章、大高　章
- Organizer
  34th European Peptide Symposium 2016 & 8th International Peptide Symposium
- Place of Presentation
  Leipzig (German）
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07858
[Presentation] SULFATED GLYCOSAMINOGLYCANS PROMOTE CELL MEMBRANE PENETRATION OF ARGININE PEPTIDES VIA ENTHALPY-DRIVEN INTERACTIONS2016
- Author(s)
  Ryo Nadai, Yuki Haraya, Kazuchika Nishitsuji, Kenji Uchimura, Kumiko Kato, Akira Shigenaga, Toru Kawakami, Akira Otaka, Hironobu Hojo, Naomi Sakashita, Hiroyuki Saito
- Organizer
  第53回ペプチド討論会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-25293006
[Presentation] タンパク質位置選択的修飾を指向したチオエステル調製法の開発2016
- Author(s)
  津田雄介、重永　章、辻　耕平、傳田将也、佐藤浩平、北風圭介、中村太寛、猪熊　翼、伊藤孝司、大髙章
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K14979
[Presentation] Tailored Synthesis of 162-Residue S-Monoglycosylated GM2-Activator Protein (GM2AP) Analogues Applicable to the Preparation of a Protein Library.2016
- Author(s)
  中村太寛、重永　章、成瀬公人、猪熊　翼、大髙　章
- Organizer
  第53回ペプチド討論会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2016-10-25
- Data Source
  KAKENHI-PROJECT-16H02611
[Presentation] 光応答型チオエステル等価体を用いた多成分One-pot NCL法の開発研究2016
- Author(s)
  山岡浩輔、粟飯原圭佑、成瀬公人、猪熊　翼、重永　章、大高　章
- Organizer
  創薬懇話会2016 in 蓼科
- Place of Presentation
  エクシブ蓼科（長野県茅野市）
- Year and Date
  2016-06-30
- Data Source
  KAKENHI-PROJECT-15K07858
[Presentation] アルギニンペプチドの細胞膜透過はグリコサミノグリカン糖鎖へのエンタルピー依存的結合によって促進される2016
- Author(s)
  灘井亮，原矢佑樹，西辻和親，内村健治，加藤くみ子，重永章，川上徹，大高章，北條裕信，坂下直実，斎藤博幸
- Organizer
  日本膜学会第38年会
- Place of Presentation
  早稲田大学西早稲田キャンパス（東京都新宿区）
- Year and Date
  2016-05-10
- Data Source
  KAKENHI-PROJECT-25293006
[Presentation] Tailored Synthesis of 162-Residue S-Monoglycosylated GM2-Activator Protein (GM2AP) Analogues Applicable to the Preparation of a Protein Library.2016
- Author(s)
  中村太寛、重永　章、成瀬公人、猪熊　翼、大髙　章
- Organizer
  第53回ペプチド討論会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-15K14979
[Presentation] 光応答型チオエステル等価体を用いた多成分One-pot NCL法の開発研究2016
- Author(s)
  山岡浩輔、粟飯原圭佑、成瀬公人、猪熊　翼、重永　章、大髙　章
- Organizer
  創薬懇話会2016 in 蓼科
- Place of Presentation
  エクシブ蓼科（長野県茅野市）
- Year and Date
  2016-06-30
- Data Source
  KAKENHI-PROJECT-15K14979
[Presentation] アミロイドーシス変異アポA-I Iowaの脂質膜結合状態の解析2016
- Author(s)
  水口智晴，三河志穂，馬場照彦，島内寿徳，重永章，奥平桂一郎，大高章，斎藤博幸
- Organizer
  膜シンポジウム2016
- Place of Presentation
  関西大学（大阪府吹田市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-25293006
[Presentation] シクロデキストリン架橋型キトサン-pH応答性ペプチド複合体による細胞コレステロール排出促進作用2015
- Author(s)
  武知佑樹, 田中健斗，辻耕平，麻見安雄，井澤浩則，重永章，大高章，川上亘作，斎藤博幸
- Organizer
  日本膜学会第37年会
- Place of Presentation
  早稲田大学西早稲田キャンパス（東京都）
- Year and Date
  2015-05-14
- Data Source
  KAKENHI-PROJECT-25293006
[Presentation] 化学合成によるタンパク質製剤調製への挑戦2015
- Author(s)
  大髙章, 佐藤浩平, 重永章
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  あわぎんホール（徳島県徳島市）
- Year and Date
  2015-06-24
- Invited
- Data Source
  KAKENHI-PROJECT-15K14979
[Presentation] N-Sulfanylethylanilide peptide as a crypto thioester for protein chemical synthesis2015
- Author(s)
  Akira Otaka
- Organizer
  5th Modern Solid Phase Peptide Synthesis & Its Application Symposium
- Place of Presentation
  Queensland Australia
- Year and Date
  2015-10-22
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14979
[Presentation] Preparation of peptide thioesters from naturally occuring sequences using a chemical protocol2015
- Author(s)
  宮島凜, 津田雄介, 猪熊翼, 重永章, 大髙章
- Organizer
  第52回ペプチド討論会
- Place of Presentation
  平塚市中央公民館（神奈川県平塚市）
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-15K14979
[Presentation] タンパク質自己編集システムを範としたアミド結合切断反応の開発2015
- Author(s)
  小宮千明、粟飯原圭佑、猪熊　翼、重永　章、大高　章
- Organizer
  第三十一回若手化学者のための化学道場
- Place of Presentation
  淡路夢舞台国際会議場（兵庫県淡路市）
- Year and Date
  2015-08-27
- Data Source
  KAKENHI-PROJECT-15K07858
[Presentation] アポA-Iアミロイド線維形成に与える脂質膜とヘパリンの影響2015
- Author(s)
  三河志穂、水口智晴、辻耕平、重永章、島内寿徳、大高章、斎藤博幸
- Organizer
  日本膜学会第37年会
- Place of Presentation
  早稲田大学西早稲田キャンパス（東京都）
- Year and Date
  2015-05-14
- Data Source
  KAKENHI-PROJECT-25293006
[Presentation] インテインに学ぶ標的タンパク質研究手法の開発2014
- Author(s)
  大高　章、重永　章
- Organizer
  日本薬学会第１３４回年会
- Place of Presentation
  熊本大学（熊本県熊本市）
- Invited
- Data Source
  KAKENHI-PROJECT-25670058
[Presentation] インテインに学ぶ標的タンパク質研究手法の開発2014
- Author(s)
  大高　章、重永　章
- Organizer
  日本薬学会第１３４回年会
- Place of Presentation
  熊本大学（熊本県）
- Invited
- Data Source
  KAKENHI-PUBLICLY-24102521
[Presentation] 標的タンパク質の効率的濃縮および選択的ラベル化を可能とする新規リンカー分子の開発2014
- Author(s)
  森崎巧也、山本純、重永章、佐藤陽一、猪熊翼、山内あい子、大高章
- Organizer
  日本薬学会第１３４回年会
- Place of Presentation
  熊本大学（熊本県熊本市）
- Data Source
  KAKENHI-PROJECT-25670058
[Presentation] フラグメントペプチドを用いたアポA-Iアミロイド線維形成領域の同定2014
- Author(s)
  足立愛美，辻耕平，川島浩之，重永章，長尾耕治郎，赤路健一，大高章，斎藤博幸
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市総合体育館（熊本県）
- Data Source
  KAKENHI-PROJECT-25293006
[Presentation] GM2活性化タンパク質の収束的合成研究2014
- Author(s)
  佐藤浩平、北風圭介、坂本　健、重永　章、辻　大輔、伊藤孝司、大高　章
- Organizer
  日本薬学会第１３４回年会
- Place of Presentation
  熊本大学（熊本県熊本市）
- Data Source
  KAKENHI-PROJECT-24390026
[Presentation] ラベル化試薬“SEAL-tag”の開発とCOX-1およびhCA1のラベル化2014
- Author(s)
  傳田将也、山本純、佐藤浩平、坂本健、重永章、佐藤陽一、山内あい子、大高章
- Organizer
  日本薬学会第１３４回年会
- Place of Presentation
  熊本大学（熊本県熊本市）
- Data Source
  KAKENHI-PROJECT-25670058
[Presentation] インテインに学ぶ標的タンパク質研究手法の開発2014
- Author(s)
  大高　章、重永　章
- Organizer
  日本薬学会第１３４回年会
- Place of Presentation
  熊本大学（熊本県熊本市）
- Invited
- Data Source
  KAKENHI-PROJECT-24390026
[Presentation] 標的タンパク質の効率的濃縮および選択的ラベル化を可能とする新規リンカー分子の開発2014
- Author(s)
  森崎巧也、山本　純、重永　章、佐藤陽一、猪熊　翼、山内あい子、大高　章
- Organizer
  日本薬学会第１３４回年会
- Place of Presentation
  熊本大学（熊本県）
- Data Source
  KAKENHI-PUBLICLY-24102521
[Presentation] 標的タンパク質を釣り上げろ！～トレーサブルリンカーの開発～2013
- Author(s)
  山本　純、北　未来、重永　章、佐藤陽一、山内あい子、大高　章
- Organizer
  第45回若手ペプチド夏の勉強会
- Place of Presentation
  八王子セミナーハウス（東京都）
- Data Source
  KAKENHI-PUBLICLY-24102521
[Presentation] Development of thiol-responsive traceable linker for efficient enrichment and selective labeling of target proteins2013
- Author(s)
  山本純(大高章)
- Organizer
  4th Asia-Pacific International Peptide Symposium, 50th Japanese Peptide Symposium
- Place of Presentation
  ホテル阪急エキスポパーク(大阪府)
- Year and Date
  2013-11-07
- Data Source
  KAKENHI-PROJECT-23390026
[Presentation] Application of peptidyl prolyl thioesters to native chemical ligation2013
- Author(s)
  中村太寛、重永章、佐藤浩平、津田雄介、坂本健、大高章
- Organizer
  4th Asia-Pacific International Peptide Symposium, 50th Japanese Peptide Symposium
- Place of Presentation
  ホテル阪急エキスポパーク（大阪府吹田市）
- Data Source
  KAKENHI-PROJECT-24390026
[Presentation] Chemical Protein Synthesis Using N-Sulfanylethylanilide Peptid.2012
- Author(s)
  Otaka, A
- Organizer
  The 14rd Akabori Conference
- Place of Presentation
  北海道
- Year and Date
  2012-09-12
- Data Source
  KAKENHI-PROJECT-23659055
[Presentation] 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦2012
- Author(s)
  大高　章
- Organizer
  第101回有機合成シンポジウム2012年【春】
- Place of Presentation
  慶應義塾大学薬学部マルチメディア講堂（東京都）
- Invited
- Data Source
  KAKENHI-PUBLICLY-24102521
[Presentation] 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦2012
- Author(s)
  大高　章
- Organizer
  第101回有機合成シンポジウム2012年【春】
- Place of Presentation
  慶應義塾大学薬学部ﾏﾙﾁﾒﾃﾞｨｱ講堂（東京都）
- Invited
- Data Source
  KAKENHI-PROJECT-23659055
[Presentation] Development of ``Tracable Linker''for Protein Idebtification Using Stimulus-responsive Amino Acid2012
- Author(s)
  Otaka A
- Organizer
  The 1st International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity
- Place of Presentation
  京都センチュリーホテル（京都府）
- Data Source
  KAKENHI-PUBLICLY-24102521
[Presentation] Chemical Protein Synthesis Using N-Sulfanylethylanilide Peptid2012
- Author(s)
  Otaka A
- Organizer
  The 14rd Akabori Conference
- Place of Presentation
  ヒルトンニセコビレッジ (北海道)(招待・依頼講演)
- Year and Date
  2012-09-12
- Data Source
  KAKENHI-PROJECT-24390026
[Presentation] N-Sulfanylethylanilides as a Versatile Chemical Device for the Protein Chemistry2012
- Author(s)
  Otaka, A
- Organizer
  2012 SNU symposium on Medicinal Chemistry
- Place of Presentation
  ソウル大学, Seoul, Korea
- Year and Date
  2012-05-15
- Data Source
  KAKENHI-PROJECT-23659055
[Presentation] N-Sulfanylethylanilides as a Versatile Chemical Device for the Protein Chemistry2012
- Author(s)
  Otaka A
- Organizer
  2012 SNU symposium on Medicinal Chemistry
- Place of Presentation
  ソウル国立大学薬学部（Seoul, Korea）
- Invited
- Data Source
  KAKENHI-PROJECT-23390026
[Presentation] 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦2012
- Author(s)
  大高　章
- Organizer
  アステラス製薬シンポジウム
- Place of Presentation
  アステラスつくば研究センター（茨城県）
- Invited
- Data Source
  KAKENHI-PROJECT-23390026
[Presentation] Chemical Protein Synthesis Using N-Sulfanylethylanilide Peptid2012
- Author(s)
  Otaka A
- Organizer
  The 14rd Akabori Conference
- Place of Presentation
  ヒルトンニセコビレッジ（北海道）
- Invited
- Data Source
  KAKENHI-PUBLICLY-24102521
[Presentation] N-Sulfanylethylanilide peptide for peptide engineering2012
- Author(s)
  Otaka A
- Organizer
  The Sixth Peptide Engineering Meeting
- Place of Presentation
  Emory大学コンファレンスセンター（Atlanta, USA）
- Data Source
  KAKENHI-PUBLICLY-24102521
[Presentation] N-Sulfanylethylanilides as a Versatile Chemical Device for the Protein Chemistry2012
- Author(s)
  Otaka, A
- Organizer
  2012 SNU symposium on Medicinal Chemistry
- Place of Presentation
  Seoul, Korea
- Year and Date
  2012-05-14
- Data Source
  KAKENHI-PROJECT-21390031
[Presentation] Chemical Protein Synthesis Using N-Sulfanylethylanilide Peptid2012
- Author(s)
  Otaka A
- Organizer
  The 14rd Akabori Conference
- Place of Presentation
  ヒルトンニセコビレッジ（北海道）
- Invited
- Data Source
  KAKENHI-PROJECT-23390026
[Presentation] 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦2012
- Author(s)
  大高　章
- Organizer
  第101回有機合成シンポジウム2012年【春】
- Place of Presentation
  慶應義塾大学薬学部ﾏﾙﾁﾒﾃﾞｨｱ講堂（東京都）
- Invited
- Data Source
  KAKENHI-PROJECT-23390026
[Presentation] 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦2012
- Author(s)
  大高　章
- Organizer
  アステラス製薬シンポジウム
- Place of Presentation
  アステラスつくば研究センター（茨城県）
- Invited
- Data Source
  KAKENHI-PUBLICLY-24102521
[Presentation] N-Sulfanylethylanilide peptide for peptide engineering2012
- Author(s)
  Otaka A
- Organizer
  The Sixth Peptide Engineering Meeting
- Place of Presentation
  Emory大学コンファレンスセンター（Atlanta, USA）
- Data Source
  KAKENHI-PROJECT-23659055
[Presentation] N-Sulfanylethylanilide peptide for peptide engineering2012
- Author(s)
  Otaka A
- Organizer
  The Sixth Peptide Engineering Meeting
- Place of Presentation
  Emory大学コンファレンスセンター (Atlanta, USA)
- Year and Date
  2012-10-02
- Data Source
  KAKENHI-PROJECT-24390026
[Presentation] N-Sulfanylethylanilides as a Versatile Chemical Device for the Protein Chemistry2012
- Author(s)
  Otaka A
- Organizer
  2012 SNU symposium on Medicinal Chemistry
- Place of Presentation
  ソウル国立大学薬学部（Seoul, Korea）
- Invited
- Data Source
  KAKENHI-PROJECT-23659055
[Presentation] Chemical Protein Synthesis Using N-Sulfanylethylanilide Peptid2012
- Author(s)
  Otaka A
- Organizer
  The 14rd Akabori Conference
- Place of Presentation
  ヒルトンニセコビレッジ（北海道）
- Invited
- Data Source
  KAKENHI-PROJECT-23659055
[Presentation] 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦2012
- Author(s)
  大高　章
- Organizer
  アステラス製薬シンポジウム
- Place of Presentation
  アステラスつくば研究センター（茨城県）
- Invited
- Data Source
  KAKENHI-PROJECT-23659055
[Presentation] 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦2012
- Author(s)
  大高章
- Organizer
  アステラス製薬シンポジウム
- Place of Presentation
  アステラスつくば研究センター (茨城県)(招待・依頼講演)
- Year and Date
  2012-08-08
- Data Source
  KAKENHI-PROJECT-24390026
[Presentation] 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦2012
- Author(s)
  大高章
- Organizer
  第101回有機合成シンポジウム 2012 年【春】
- Place of Presentation
  慶應義塾大学、東京都
- Year and Date
  2012-06-06
- Data Source
  KAKENHI-PROJECT-23659055
[Presentation] N-Sulfanylethylanilide peptide for peptide engineering2012
- Author(s)
  Otaka A
- Organizer
  The Sixth Peptide Engineering Meeting
- Place of Presentation
  Emory大学コンファレンスセンター（Atlanta, USA）
- Data Source
  KAKENHI-PROJECT-23390026
[Presentation] 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦2012
- Author(s)
  大高章
- Organizer
  第101回有機合成シンポジウム2012年【春】
- Place of Presentation
  慶應義塾大学薬学部マルチメディア講堂 (東京都)(招待・依頼講演)
- Year and Date
  2012-06-06
- Data Source
  KAKENHI-PROJECT-24390026
[Presentation] N-Sulfanylethylanilides as a Versatile Chemical Device for the Protein Chemistry2012
- Author(s)
  Otaka A
- Organizer
  2012 SNU symposium on Medicinal Chemistry
- Place of Presentation
  ソウル国立大学薬学部（Seoul, Korea）
- Invited
- Data Source
  KAKENHI-PUBLICLY-24102521
[Presentation] N-Sulfanylethylanilides as a Versatile Chemical Device for the Protein Chemistry2012
- Author(s)
  Otaka A
- Organizer
  2012 SNU symposium on Medicinal Chemistry
- Place of Presentation
  ソウル国立大学薬学部 (Seoul, Korea)(招待・依頼講演)
- Year and Date
  2012-05-14
- Data Source
  KAKENHI-PROJECT-24390026
[Presentation] Development of nucleocytoplasmic shuttle peptide using stimulus-responsive processing device2011
- Author(s)
  大高章
- Organizer
  日本生物物理学会第49回年会
- Place of Presentation
  兵庫県立大学姫路書写キャンパス(兵庫県)
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-23390026
[Presentation] Development of nucleocytoplasmic shuttle peptide using stimulus-responsive processing device2011
- Author(s)
  大高章
- Organizer
  日本生物物理学会第49回年会
- Place of Presentation
  兵庫県立大学(姫路市)(招待講演)
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-21390031
[Presentation] Development of nucleocytoplasmic shuttle peptide using stimulus-responsive processing device2011
- Author(s)
  大高　章
- Organizer
  日本生物物理学会第４９回年会(招待講演)
- Place of Presentation
  兵庫県立大学（姫路市）
- Data Source
  KAKENHI-PROJECT-23659055
[Presentation] Development of nucleocytoplasmic shuttle peptide using stimulus-responsive processing device2011
- Author(s)
  大高章、重永章
- Organizer
  日本生物物理学会第49回年会
- Place of Presentation
  兵庫県立大学、兵庫県
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-23659055
[Presentation] Development of peptide bond cleavage device and its application for chemical biology use2010
- Author(s)
  大高章
- Organizer
  The 13rd Akabori Conference
- Place of Presentation
  Leipzig, Germany
- Year and Date
  2010-09-11
- Data Source
  KAKENHI-PROJECT-21390031
[Presentation] Development of amide bond cleavage device with application to chemical biology use2010
- Author(s)
  大高章
- Organizer
  5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium
- Place of Presentation
  京都市
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21390031
[Presentation] Development of amide bond cleavage device with application to chemical biology use2010
- Author(s)
  Otaka, A.; Shigenaga, A
- Organizer
  5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2010-12-05
- Data Source
  KAKENHI-PROJECT-21390031
[Presentation] 分子内NCLを利用した環状ペプチド合成法の開発(2)2009
- Author(s)
  西山由希子、中本亜樹、重永章、大高章
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] 分子内NCLを利用した環状ペプチド合成法の開発(1)2009
- Author(s)
  前田奈美、津田修吾、石澤祥衣、重永章、大高章
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] 光刺激応答型アミド結合切断反応のケージドセラミド創製への応用2009
- Author(s)
  平川寛子、西岡直美、山口圭子、重永童、大高章
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] Amide bond cleavage for the preparation of functional peptides2009
- Author(s)
  大高章
- Organizer
  Roche Colorado Corporation Peptide Symposium
- Place of Presentation
  Colorado, USA
- Year and Date
  2009-09-27
- Data Source
  KAKENHI-PROJECT-18032051
[Presentation] 任意の刺激応答型ペプチド結合切断デバイスの反応速度に与えるアミノ酸配列の影響2009
- Author(s)
  重永章、山本純、平川寛子、山口圭子、大高章
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] 蛋白質化学合成を指向した無保護ペプチドフラグメント順次縮合法の開発2009
- Author(s)
  庄川栄健、津田修吾、重永章、大高章
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] ペプチド結合切断能を有する側鎖修飾型アスパラギンの開発2008
- Author(s)
  森下巧、津田修吾、前田奈美、重永章、大高章
- Organizer
  第47回日本薬学会病院薬剤師会中国四国支部学術大会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] チオカルボン酸を利用した化学的蛋白質合成法の開発に関する研究2008
- Author(s)
  住川栄健、津田修吾、重永章、大高章
- Organizer
  第24回若手化学者のための化学道場
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] 任意の刺激応答型ペプチド結合切断デバイスの開発2008
- Author(s)
  重永章、西岡直美、山本純、大高章
- Organizer
  日本ケミカルバイオロジー研究会第3回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] Cleavage of peptide bonds for the preparation of functional peptides2008
- Author(s)
  大高章、重永章、西岡直美、辻大輔、伊藤孝司
- Organizer
  The 12th Japan-Korea Joint Symposium on Drug Design and Development
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] The application of peptide thioacids to NGL-type sequential condensation of peptide fragments2008
- Author(s)
  住川栄健、津田修吾、重永章、大高章
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] ペプチド結合切断能を有する光応答型アミノ酸の開発と核一細胞質シャトルペプチドへの応用2008
- Author(s)
  重永章、辻大輔、西岡直美、山本純、津田修吾、伊藤孝司、大高章
- Organizer
  日本薬学会第128回年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] 光刺激応答型アミド結合切断反応を利用したケージドセラミドの創製2008
- Author(s)
  平川寛子、西岡直美、山口圭子、重永章、大高章
- Organizer
  第47回日本薬学会病院薬剤師会中国四国支部学術大会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] 光刺激応答型アミド結合切断デバイスを利用したケージドセラミドの創製2008
- Author(s)
  平川寛子、西岡直美、山口圭子、重永章、大高章
- Organizer
  創薬懇話会2008
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] 近赤外二光子励起応答型ペプチド結合切断デバイスの開発2008
- Author(s)
  山本純、住川栄健、西岡直美、重永章、古田寿昭、大高章
- Organizer
  第47回日本薬学会病院薬剤師会中国四国支部学術大会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] N-Sアシルシフトを利用した環状ペプチドライブラリー構築の試み2008
- Author(s)
  前田奈美、津田修吾、重永章、大高章
- Organizer
  第47回日本薬学会病院薬剤師会中国四国支部学術大会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] Development of UV irradiation-responsive amino acid with peptide bond cleavage ability and its application to a nucleocytoplasmic shuttle peptide2008
- Author(s)
  津田修吾、重永章、辻大輔、西岡直美、住川栄健、伊藤孝司、大高章
- Organizer
  第22回内藤コンファレンス
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] Synthesis of peptide thioester using N-substituted aniline derivatives2008
- Author(s)
  津田修吾、前田奈美、坂東清美、重永章、大高章
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] Synthesis of fluoroalkene dipeptide isosteres utilizing intramolecular redox reaction catalyzed by N-heterocyclic carbene2008
- Author(s)
  八巻陽子、重永章、大高章
- Organizer
  The l2th Japan-Korea Joint Symposium on Drug Design and Development
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] Influence of anamino acid sequence on kinetics of peptide bond cleavage reaction induced byastimulus-responsiveamino acid2008
- Author(s)
  重永章、西岡直美、山本純、平川寛子、住川栄健、山口圭子、大高章
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] Cleavage of peptide bonds for the preparation of functional peptides2008
- Author(s)
  大高章
- Organizer
  The 12th Japan-Korea Joint Symposium on Drug Design and Development
- Place of Presentation
  仙台
- Year and Date
  2008-05-14
- Data Source
  KAKENHI-PROJECT-19651096
[Presentation] Synthesis of fluoroalkene dipeptide isostere utilizing intramolecular redox reaction2008
- Author(s)
  八巻陽子、重永章、大高章
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] 分子内redox反応を利用したフルオロアルケンジペプチドイソスターの合成2008
- Author(s)
  八巻陽子、重永章、大高章
- Organizer
  第34回反応と合成の進歩シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] 人工プロテインスプライシングシステムにおけるペプチド結合切断のための側鎖修飾型アスパラギンの検討2008
- Author(s)
  津田修吾、前田奈美、重永章、大高章
- Organizer
  日本薬学会第128回年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] 機能性ペプチドの創製を目指したアミド結合切断法の開発2007
- Author(s)
  津田修吾、前田奈美、西岡直美、重永章、大高章
- Organizer
  第46回日本薬学会病院薬剤師会中国四国支部学術大会
- Place of Presentation
  高知
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] Development of amino acid derivative with amide cleavage ability and its use for the design of shuttle peptides2007
- Author(s)
  大高章、重永章、辻大輔、西岡直美、津田修吾、伊藤孝司
- Organizer
  4^<th>International Peptide Symposium in conjunction with 7^<th> Australian Aeptide Conference and 2^<nd> Asia-Facific International Peptide Symposium
- Place of Presentation
  Queensland, Australia
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] 有機銅試薬を用いたS_N2'型アリル化反応の開発とプロリン型ジペプチドイソスターの合成2007
- Author(s)
  山口圭子、辻貴志、佐々木義一、重永童、大高章
- Organizer
  第46回日本薬学会病院薬剤師会中国四国支部学術大会
- Place of Presentation
  高知
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] Amide bond cleavage for the preparation of functional peptides2007
- Author(s)
  大高章
- Organizer
  Roche Colorado Corporation Peptide Symposium
- Place of Presentation
  Colorado,USA
- Year and Date
  2007-09-27
- Data Source
  KAKENHI-PROJECT-19651096
[Presentation] Development of stimulus-responsive amino acid with peptide bond-cleavage ability and it sapplication to a nucleocytoplasmic shuttle peptide2007
- Author(s)
  重永章、辻大輔、西岡直美、津田修吾、伊藤孝司、大高章
- Organizer
  第44回ペプチド討論会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] N-ヘテロサイクリックカルベンを利用したフルオロアルケンイソスターの合成2007
- Author(s)
  八巻陽子、住川栄健、重永章、大高章
- Organizer
  第46回日本薬学会病院薬剤師会中国四国支部学術大会
- Place of Presentation
  高知
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] Amide bond cleavage for the preparation of functional peptides2007
- Author(s)
  大高章
- Organizer
  Roche Colorado Corporation Peptide Symposium
- Place of Presentation
  Colorado,USA
- Year and Date
  2007-09-27
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] 刺激応答型アミノ酸を利用した核上細胞質シャトルペプチドの開発2007
- Author(s)
  重永章、辻大輔、津田修吾、伊藤孝司、大高章
- Organizer
  日本ケミカルバイオロジー研究会第2回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] N-ヘテロサイクリックカルベンによる分子内レドックス反応を利用したフルオロアルケンイソスターの合成2007
- Author(s)
  八巻陽子、重永章、富田健嗣、鳴海哲夫、藤井信孝、大高章
- Organizer
  日本薬学会第127回年会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] 外部刺激応答型ペプチドプロセシングデバイスの開発2007
- Author(s)
  重永章、津田修吾、大高章
- Organizer
  日本薬学会第127回年会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] ペプチド結合切断能を有する刺激応答型アミノ酸の開発と核一細胞質シャトルペプチドへの展開2007
- Author(s)
  重永章、辻大輔、西岡直美、津田修吾、伊藤孝司、大高章
- Organizer
  第33回反応と合成の進歩シンポジウム
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] Developlnent of Photo-responsive Self-processing Peptides2006
- Author(s)
  重永章、新宅沙織、大高章
- Organizer
  43rd Japanese Peptide Symposium/4th Peptide Engineering Meeting
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] Synthesis of (Z)-alkene cis-Xaa-Pro type dipeptide isosteres using organocopper-mediated anti-SN2'reactions2006
- Author(s)
  辻貴志、佐々木義一、山口圭子、重永章、藤井信孝、大高章
- Organizer
  43rd Japanese Peptide Symposium/4th Peptide Engineering Meeting
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] 光刺激応答型ペプチドの開発と速度論的検討2006
- Author(s)
  重永章、新宅沙織、大高章
- Organizer
  第7回長井長義記念シンポジウム
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] Development of Photo-triggered Seif-processing Peptides2006
- Author(s)
  重永章、新宅沙織、大高章
- Organizer
  ICOB-5&ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] Ragio-and Stereoselective Synthesis of(Z)-Alkene cis-Xaa-Pro Dipeptide Mimetics with Organocopper-mediated Anti-SN2'Reactions2006
- Author(s)
  佐々木義一、辻貴志、新居田歩、重永章、藤井信孝、大高章
- Organizer
  29th European Peptide Symposium
- Place of Presentation
  Gdansk,Poland
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] 外部刺激応答型ペプチドの合成と外部刺激応答能の検討2006
- Author(s)
  重永章、新宅沙織、大高章
- Organizer
  第32回反応と合成の進歩シンポジウム
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] 有機銅試薬を用いたプロリン型(Z)-アルケンジペプチドイソスターの立体選択的合成・研究2006
- Author(s)
  辻貴志佐々木義一、山口圭子、重永章、藤井信孝、大高章
- Organizer
  第45回日本薬学会病院薬剤師会中国四国支部学術大会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] Development of Chemical Devices for Chemical Legations2006
- Author(s)
  大高章、太田悠介、重永章、藤井信孝
- Organizer
  The 11^<th> Akabori Conference
- Place of Presentation
  Kloster Danz, Germany
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] Design, Synthesis and Photo-processing Reaction of Peptides Possessing the External Stimulus-responsive Amino Acid2006
- Author(s)
  重永章、新宅沙織、大高章
- Organizer
  29th European Peptide Symposium
- Place of Presentation
  Gdansk, Poland
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] Preparation of peptide thioaster utilizing S-protected oxazalidinone derived from systeine2006
- Author(s)
  大高章、太田悠介、重永章、藤井信孝
- Organizer
  The 11th Korea-Japan Joint Symposium On Drug Design and Development
- Place of Presentation
  Jeju Island, Korea
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] Synthesis of (Z)-alkane-containing Pro dipeptide isosteres corresponding to cis-prolyl peptides2006
- Author(s)
  佐々木義一、新居田歩、辻貴志、重永章、藤井信孝、大高章
- Organizer
  The 11th Korea-Japan Joint Symposium On Drug Design and Development
- Place of Presentation
  Jeju Island, Korea
- Data Source
  KAKENHI-PROJECT-18390006
[Presentation] Chemical thioester synthesis applicable to naturally occurring peptide sequence
- Author(s)
  A. Otaka, Y. Tsuda, A. Shigenaga
- Organizer
  15th Akabori Conference Japanese-German Symposium on Peptide Science,
- Place of Presentation
  Best Western Premier Bellevue Rheinhotel （ボッパルド, ドイツ）
- Year and Date
  2014-09-08 – 2014-09-09
- Data Source
  KAKENHI-PROJECT-24390026
[Presentation] One-pot chemical synthesis of CXCL14 using N-sulfanylethylanilide peptide
- Author(s)
  Kohei Tsuji, Kohei Sato, Ken Sakamoto, Kosuke Tanegashima, Akira Shigenaga, Tsubasa Inokuma, Takahiko Hara and Akira Otaka
- Organizer
  51th The Japanese Peptide Society
- Place of Presentation
  徳島大学（徳島県徳島市）
- Year and Date
  2014-10-22 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-25670058
[Presentation] アルギニン変異apoA-Iフラグメントのアミロイド線維形成性
- Author(s)
  三河志穂，水口智晴，辻耕平，馬場照彦，重永章，大高章，斎藤博幸
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸サンボーホール（兵庫県神戸市）
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25293006
[Presentation] Development of N-glycosylated asparagine ligation and its application to total chemical synthesis of GM2 activator protein
- Author(s)
  Kohei Sato, Keisuke Kitakaze, Ken Sakamoto, Akira Shigenaga, Tsubasa Inokuma, Daisuke Tsuji, Kouji Itou and Akira Otaka
- Organizer
  51th The Japanese Peptide Society
- Place of Presentation
  徳島大学（徳島県徳島市）
- Year and Date
  2014-10-22 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-25670058
[Presentation] Chemical protein synthesis utilizing SEAlide technology that is potentially applicable to incorporation of artificial amino acids into proteins for their functional controｌ
- Author(s)
  Akira Shigenaga, Kohei Sato, Tsubasa Inokuma and Akira Otaka
- Organizer
  The 2nd International Symposium on Fusion Materials Program
- Place of Presentation
  東京大学（東京都文京区）
- Year and Date
  2014-11-02 – 2014-11-04
- Data Source
  KAKENHI-PROJECT-24390026
[Presentation] 固-液融合型ペプチド合成法を用いた架橋ペプチド効率的合成法の開発
- Author(s)
  粟飯原圭佑, 小宮千明, 重永章, 猪熊翼, 高橋大輔, 大髙章
- Organizer
  第40回反応と合成の進歩シンポジウム
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2014-11-10 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-24390026
[Presentation] インテインに学ぶ標的タンパク質研究手法の開発
- Author(s)
  大高　章、重永　章
- Organizer
  日本薬学会第１３４回年会
- Place of Presentation
  熊本大学（熊本県）
- Invited
- Data Source
  KAKENHI-PROJECT-23390026
[Presentation] GM2活性化タンパク質誘導体の第二世代化学合成法の開発研究
- Author(s)
  中村太寛, 重永章, 佐藤浩平, 津田雄介, 坂本健, 猪熊翼, 大髙章
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学（兵庫県神戸市）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24390026
[Presentation] Synthetic study of GM2 activator protein using N-sulfanylethylanilide peptide
- Author(s)
  K. Sato, K. Kitakaze, K. Sakamoto, A. Shigenaga, D. Tsuji, Kouji Itou, A. Otaka
- Organizer
  The 33rd European Peptide Symposium
- Place of Presentation
  国立文化パレス（ソフィア, ブルガリア）
- Year and Date
  2014-09-02 – 2014-09-04
- Data Source
  KAKENHI-PROJECT-25670058
[Presentation] 新規タンパク質チオエステル調製法の開発
- Author(s)
  津田雄介, 重永章, 傳田将也, 佐藤浩平, 北風圭介, 中村太寛, 猪熊翼, 伊藤孝司, 大髙章
- Organizer
  第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  広島国際会議場（広島県広島市）
- Year and Date
  2014-11-08 – 2014-11-09
- Data Source
  KAKENHI-PROJECT-25670058
[Presentation] プロテインスプライシング模倣型ペプチド結合切断デバイスの開発研究
- Author(s)
  小宮千明, 粟飯原圭佑, 猪熊翼, 重永章, 大髙章
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学（兵庫県神戸市）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24390026
[Presentation] Dimerized CXCL14 C-terminal regions inhibit CXCL12-CXCR4 signaling axis
- Author(s)
  K. Tsuji, K. Tanegashima, Akira Shigenaga, T. Hara, A. Otaka
- Organizer
  The 33rd European Peptide Symposium
- Place of Presentation
  国立文化パレス（ソフィア, ブルガリア）
- Year and Date
  2014-09-02 – 2014-09-04
- Data Source
  KAKENHI-PROJECT-25670058
[Presentation] オレフィンメタセシスを用いた架橋ペプチド効率的合成法の開発
- Author(s)
  粟飯原圭佑, 小宮千明, 重永章, 猪熊翼, 高橋大輔, 大髙章
- Organizer
  創薬懇話会2014
- Place of Presentation
  長良川温泉ホテルパーク（岐阜県岐阜市）
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-24390026
[Presentation] 天然アミノ酸配列に適用可能な新規タンパク質チオエステル合成法の開発
- Author(s)
  津田雄介, 重永章, 佐藤浩平, 中村太寛, 北風圭介, 猪熊翼, 伊藤孝司, 大髙章
- Organizer
  日本ケミカルバイオロジー学会第9回年会
- Place of Presentation
  大阪大学（大阪府豊中市）
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-25670058
[Presentation] M6P修飾型GM2APの合成検討
- Author(s)
  成瀬公人, 佐藤浩平, 坂本健, 猪熊翼, 重永章, 大髙章
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学（兵庫県神戸市）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25670058
[Presentation] Development of N-glycosylated asparagine ligation and its application to total chemical synthesis of GM2 activator protein
- Author(s)
  Kohei Sato, Keisuke Kitakaze, Ken Sakamoto, Akira Shigenaga, Tsubasa Inokuma, Daisuke Tsuji, Kouji Itou and Akira Otaka
- Organizer
  51th The Japanese Peptide Society
- Place of Presentation
  徳島大学（徳島県徳島市）
- Year and Date
  2014-10-22 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-24390026
[Presentation] 新規タンパク質チオエステル調製法の開発
- Author(s)
  津田雄介, 重永章, 傳田将也, 佐藤浩平, 北風圭介, 中村太寛, 猪熊翼, 伊藤孝司, 大髙章
- Organizer
  第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  広島国際会議場（広島県広島市）
- Year and Date
  2014-11-08 – 2014-11-09
- Data Source
  KAKENHI-PROJECT-24390026
[Presentation] Chemical thioester synthesis applicable to naturally occurring peptide sequence
- Author(s)
  A. Otaka, Y. Tsuda, A. Shigenaga
- Organizer
  15th Akabori Conference Japanese-German Symposium on Peptide Science,
- Place of Presentation
  Best Western Premier Bellevue Rheinhotel （ボッパルド, ドイツ）
- Year and Date
  2014-09-08 – 2014-09-09
- Data Source
  KAKENHI-PROJECT-25670058
[Presentation] 細胞内シグナル伝達機構解明を指向したケージド非水解性リン酸化アミノ酸の合成とその機能評価
- Author(s)
  戎野紘司, 傳田将也, 小倉圭司, 猪熊翼, 重永章, 大髙章
- Organizer
  第40回反応と合成の進歩シンポジウム
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2014-11-10 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-24390026
[Presentation] 細胞内シグナル伝達機構解明を指向したケージド非水解性リン酸化アミノ酸の合成とその機能評価
- Author(s)
  戎野紘司, 傳田将也, 小倉圭司, 猪熊翼, 重永章, 大髙章
- Organizer
  第40回反応と合成の進歩シンポジウム
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2014-11-10 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-25670058
[Presentation] ペプチドチオエステル調製のためのクマリン型補助基の開発
- Author(s)
  江藤三弘, 傳田将也, 佐藤浩平, 坂本健, 猪熊翼, 重永章, 大髙章
- Organizer
  第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  広島国際会議場（広島県広島市）
- Year and Date
  2014-11-08 – 2014-11-09
- Data Source
  KAKENHI-PROJECT-24390026
[Presentation] 固-液融合型ペプチド合成法を用いた架橋ペプチド効率的合成法の開発
- Author(s)
  粟飯原圭佑, 小宮千明, 重永章, 猪熊翼, 高橋大輔, 大髙章
- Organizer
  第40回反応と合成の進歩シンポジウム
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2014-11-10 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-25670058
[Presentation] One-pot chemical synthesis of CXCL14 using N-sulfanylethylanilide peptide
- Author(s)
  Kohei Tsuji, Kohei Sato, Ken Sakamoto, Kosuke Tanegashima, Akira Shigenaga, Tsubasa Inokuma, Takahiko Hara and Akira Otaka
- Organizer
  51th The Japanese Peptide Society
- Place of Presentation
  徳島大学（徳島県徳島市）
- Year and Date
  2014-10-22 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-24390026
[Presentation] プロテインスプライシング模倣型ペプチド結合切断デバイスの開発研究
- Author(s)
  小宮千明, 粟飯原圭佑, 猪熊翼, 重永章, 大髙章
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学（兵庫県神戸市）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25670058
[Presentation] ペプチドチオエステル調製のためのクマリン型補助基の開発
- Author(s)
  江藤三弘, 傳田将也, 佐藤浩平, 坂本健, 猪熊翼, 重永章, 大髙章
- Organizer
  第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  広島国際会議場（広島県広島市）
- Year and Date
  2014-11-08 – 2014-11-09
- Data Source
  KAKENHI-PROJECT-25670058
[Presentation] 天然アミノ酸配列に適用可能な新規タンパク質チオエステル合成法の開発
- Author(s)
  津田雄介, 重永章, 佐藤浩平, 中村太寛, 北風圭介, 猪熊翼, 伊藤孝司, 大髙章
- Organizer
  日本ケミカルバイオロジー学会第9回年会
- Place of Presentation
  大阪大学（大阪府豊中市）
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-24390026
[Presentation] オレフィンメタセシスを用いた架橋ペプチド効率的合成法の開発
- Author(s)
  粟飯原圭佑, 小宮千明, 重永章, 猪熊翼, 高橋大輔, 大髙章
- Organizer
  創薬懇話会2014
- Place of Presentation
  長良川温泉ホテルパーク（岐阜県岐阜市）
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-25670058
[Presentation] GM2活性化タンパク質誘導体の第二世代化学合成法の開発研究
- Author(s)
  中村太寛, 重永章, 佐藤浩平, 津田雄介, 坂本健, 猪熊翼, 大髙章
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学（兵庫県神戸市）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25670058
[Presentation] 過酸化水素応答型ペプチド結合切断デバイスの開発研究
- Author(s)
  北未来, 山本純, 戎野紘司, 小宮千明, 宮本理人, 土屋浩一郎, 重永章, 大髙章
- Organizer
  日本ケミカルバイオロジー学会第9回年会
- Place of Presentation
  大阪大学（大阪府豊中市）
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-25670058
[Presentation] M6P修飾型GM2APの合成検討
- Author(s)
  成瀬公人, 佐藤浩平, 坂本健, 猪熊翼, 重永章, 大髙章
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学（兵庫県神戸市）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24390026
[Presentation] DESIGN OF NANODISC SCAFFOLD PEPTIDE (NSP)
- Author(s)
  假屋園大和, 新村航，辻耕平，重永章，大高章，斎藤博幸
- Organizer
  第51回ペプチド討論会
- Place of Presentation
  徳島大学（徳島県徳島市）
- Year and Date
  2014-10-22 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-25293006
[Presentation] Chemical protein synthesis utilizing SEAlide technology that is potentially applicable to incorporation of artificial amino acids into proteins for their functional controｌ
- Author(s)
  Akira Shigenaga, Kohei Sato, Tsubasa Inokuma and Akira Otaka
- Organizer
  The 2nd International Symposium on Fusion Materials Program
- Place of Presentation
  東京大学（東京都文京区）
- Year and Date
  2014-11-02 – 2014-11-04
- Data Source
  KAKENHI-PROJECT-25670058
[Presentation] 過酸化水素応答型ペプチド結合切断デバイスの開発研究
- Author(s)
  北未来, 山本純, 戎野紘司, 小宮千明, 宮本理人, 土屋浩一郎, 重永章, 大髙章
- Organizer
  日本ケミカルバイオロジー学会第9回年会
- Place of Presentation
  大阪大学（大阪府豊中市）
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-24390026
[Presentation] Dimerized CXCL14 C-terminal regions inhibit CXCL12-CXCR4 signaling axis
- Author(s)
  K. Tsuji, K. Tanegashima, Akira Shigenaga, T. Hara, A. Otaka
- Organizer
  The 33rd European Peptide Symposium
- Place of Presentation
  国立文化パレス（ソフィア, ブルガリア）
- Year and Date
  2014-09-02 – 2014-09-04
- Data Source
  KAKENHI-PROJECT-24390026
[Presentation] Synthetic study of GM2 activator protein using N-sulfanylethylanilide peptide
- Author(s)
  K. Sato, K. Kitakaze, K. Sakamoto, A. Shigenaga, D. Tsuji, Kouji Itou, A. Otaka
- Organizer
  The 33rd European Peptide Symposium
- Place of Presentation
  国立文化パレス（ソフィア, ブルガリア）
- Year and Date
  2014-09-02 – 2014-09-04
- Data Source
  KAKENHI-PROJECT-24390026

1. TAMAMURA Hirokazu (80217182)

# of Collaborated Projects: 13 results

# of Collaborated Products: 0 results
2. FUJII Nobutaka (60109014)

# of Collaborated Projects: 11 results

# of Collaborated Products: 3 results
3. IBUKA Toshiroh (80025692)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
4. SHIGENAGA Akira (10423394)

# of Collaborated Projects: 5 results

# of Collaborated Products: 140 results
5. HOSOTANI Ryo (00139908)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. ITOH Kohji (00184656)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
7. 河野通明 (00027335)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. SHISHIDO Kozo (20006349)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TSUJI Daisuke (00423400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. FUNAKOSHI Susumu (10135593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YAMAMOTO Yoshinori (60029519)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YAMAMOTO Naoki (00094053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Saito Hiroyuki (60300919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
14. AKAJI Kenichi (60142296)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
15. OKAMURA Emiko (00160705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KOBAYASHI Norihiro (90205477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. KITAGAWA Shuji (00108911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. MICHIKAWA Makoto (40270912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. INOKUMA Tsubasa (40541272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 22 results
20. 井上謙一郎 (40025713)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 片岡貞 (00082975)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 佐藤仁彦 (00240945)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 土井隆一郎 (20301236)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 真板宣夫 (00404046)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 広川貴次 (20357867)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
26. 原孝彦 (80280949)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
27. 笠原二郎 (10295131)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 長尾耕治郎 (40587325)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
29. TANAKA Hirokazu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 黒川勉

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 西村紀

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. KOGA Tomoaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. INAZUMI Tomoaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. YOSHIMARU Tetsuro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. TANEGASHIMA Kosuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
36. NOMURA Wataru

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
37. 杉本幸彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 山田健一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
39. 三好康雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 片桐豊雅

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 佐藤浩平

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
42. 西辻和親

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
43. 坂下直実

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 山内あい子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
45. 佐藤陽一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
46. 奥平桂一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

OTAKA Akira 大高 章

Research Projects

Research Products

Co-Researchers

Development of fluorescence probe for visualization of in-cell methylation eventsPrincipal Investigator

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次世代タンパク性医薬品開発に向けた反応システム系の開発と展開Principal InvestigatorOngoing

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Synthetic Study on Semi-synthetic AntibodyPrincipal Investigator

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Development of highly efficient labelling reagents for proteinPrincipal Investigator

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分子標的探索のための化学選択的修飾部位内在型リンカーの開発Principal Investigator

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Development of synthetic platoform of proteinsPrincipal Investigator

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Development of methodology forchemical synthesis of proteins based on kinetically controlled peptide bond formationPrincipal Investigator

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Development of methodologies for catalytic decomposition of proteinsPrincipal Investigator

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化学的アミド結合切断を基盤とする時空間制御型タンパク質機能発現調節法の開発Principal Investigator

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ウイルスの共通分子機構を標的とする抗ウイルスペプチドの開発戦略の創製Principal Investigator

Principal Investigator

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Research Institution

Davelopment of methodology for the preparation of membrane proteinsPrincipal Investigator

OTAKA Akira 大高章