SHISHIDO Kozo 宍戸宏造

Researcher Number	20006349
External Links
Affiliation (based on the past Project Information) *help	2013: 徳島大学, ヘルスバイオサイエンス研究部, 非常勤講師 2012: 徳島大学, ヘルスバイオサイエンス研究部, 特任教授 2011: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 2004 – 2007: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 2006: 徳島大学, バイオヘルスサイエンス研究部, 教授 … More 2005 – 2006: 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 1999 – 2003: 徳島大学, 薬学部, 教授 1993 – 1997: 徳島大学, 薬学部, 教授 1995 – 1996: 徳島大学, 薬学部・附属医薬資源教育研究センター, 教授 1993: 徳島大学, 薬学部・付属医薬資源教育研究センター, 教授 1990 – 1992: 徳島大学, 薬学部, 助教授 Less
Review Section/Research Field	Principal Investigator Chemical pharmacy / Science and Engineering / Chemical pharmacy / Drug development chemistry / Bioorganic chemistry Except Principal Investigator Chemical pharmacy / Bioorganic chemistry
Keywords	Principal Investigator エナンチオ選択的合成 / 細胞毒性 / アポトーシス / 不斉合成 / 全合成 / apoptosis / アレロパシー / enantioselective synthesis / total synthesis / lasonolide A … More / cell adhesion molecules / ラソノリドA / 細胞接着 / ヘリビサボノール / セスキテルペン / ヘリスピロン / ヘリアンヌオール / 大腸癌 / 植物生育阻害活性 / スピロ環 / ブレビオン / 抗腫瘍活性 / フラン / NF-kB inhibitor / breviones / sundiversifolide / heliannuols / drug seeds / allolochemical / agrichemical / 糖尿病 / 核内転写因子 / サンディバーホリド / アレロケミマル / 抗大腸癌活性 / ヒマワリ / アレロケミカル / 医薬品シーズ / 環境調和型農薬 / ring closing metathesis / intramolecular Michael reactions / cytotoxicity / polyketide / ヒドロピラン / 閉環メタセシス / 分子内マイケル反応 / エナンチオ選択合成 / 細胞接着誘導阻害 / ポリケタイド / Suzuki-coupling / bongkrekic acid / 高井法 / ミトコンドリア / 不斉アルキル化 / 全合成研究 / 鈴木カップリング / ボンクレキン酸 / halichlorine / macrolide / alkaloid / anti-arteriosclerosis / 海洋産天然物 / パン酵母 / 動脈硬化 / ハリクロリン / マクロリド / アルカロイド / 抗動脈硬化 / 細胞接着分子 / 標的タンパク同定 / クリックケミストリー / 光親和性標識 / ビオチン / アスパーギライド / プルダウンアッセイ / 標的タンパク質 / プロテオミクス / プルダウン法 / ベイト分子 / ケミカルバイオロジー / 標的タンパク / 創薬 / 天然物 / セスキテルペノイド / ルイス酸 / ジテルペノイド / スピロ化合物 / シクロペンタノン / シクロヘキサノン / コンホメーション制御 / フラグメンテーション / シグマラジカル / アシルラジカル / 光学分割 / リパーゼ / テルペン / 慢性関節リウマチ / インターロイキン-1 / 環拡大反応 / ラジカル環化 / DNA切断活性 / キラル合成 / アジノマイシン / キノン / タンシノン / ノルジテルペン / 分子内付加環化 / 向神経薬 / アゴニスト / ベンゾジアゼピン / テトロン酸 / 不斉四級炭素 / セスタテルペン / ヒッポスポンジン / 海産天然物 / アセチルコリンエステラ-ゼ阻害 / ビンドリン / アルツハイマ-型痴呆症 / インド-ルアルカロイド / フィゾスチグミン / フィゾベニン / カラバル豆アルロイド / 分子内環状付加反応 … More Except Principal Investigator 合成 / エンジイン / 切断 / DNA / Tripterygium / Celastraceae / 植物組織培養 / トリテルペン / クロズル / ニシキギ科 / ラジカル / Vitamin B6 / radical / Dynemicin / cascade / enzyme-inhibition / synthesis / enyne-allene / ビタミンB6 / ダイネミシン / カスケード / 酵素阻害剤 / エンインアレン / callus / NO / quinoide / diterpene / triptoquinone / interleukin-1 / rheumatoid arthritis / 抗炎症 / 慢性関節リウマチ / カルス / キノイド / ジテルペン / 一酸化窒素 / トリプトキノン / インターロイキン-1 / リウマチ / TPA / triptofordin / Triptogelin / two-stage carcinogenic test / antitumor promoter / sesquiterpene / 植物成分 / スチルベン / マウス皮膚二段階発がん / ウイルス / セスキテルペン / 抗発がんプロモーター / がん / α、β不飽和カルボン酸 / βラクトン / ブロモエステル / エステルジアニオン / ケテンアニオン / イノラート / 芳香族 / トリガー / レキシトロプシン / モデル化合物 / 抗癌剤 / エスペラミシン Less

Development and application of efficient identification method for drugable proteins based on natural products and bioorganic chemistriesPrincipal Investigator
- Principal Investigator
  
  SHISHIDO Kozo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokushima
ヘリアナンセスキテルペンのエナンチオ制御合成Principal Investigator
- Principal Investigator
  
  宍戸宏造
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokushima
生物活性スピロジテルペノイドの合成研究Principal Investigator
- Principal Investigator
  
  宍戸宏造
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokushima
Development of the Environmentally Benign Agrichemicals and Novel Drug Seeds Based on Natural AllelochemicalsPrincipal Investigator
- Principal Investigator
  
  SHISHIDO Kozo
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokushima
Synthesis and Functional Analysis of Cell Adhesion Inhibitory PolyketidesPrincipal Investigator
- Principal Investigator
  
  SHISHIDO Kozo
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokushima
コンホメーション規制による新規アシルラジカル生成法の関発と機能開拓Principal Investigator
- Principal Investigator
  
  宍戸宏造
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokushima
Chemical Approach to Explicate the Molecular Mechanism for ApoptosisPrincipal Investigator
- Principal Investigator
  
  SHISHIDO Kozo
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokushima
Studies on the development of drugs for arteriosclerosis based on the inhibition of cell adhesion molecules' inductionPrincipal Investigator
- Principal Investigator
  
  SHISHIDO Kozo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokushima
イノラートの合成と反応
- Principal Investigator
  
  SHINDO Mitsuru
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
生理活性物質の合成を指向したラジカル環化プロセスの開発と展開Principal Investigator
- Principal Investigator
  
  宍戸宏造
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokushima
Studies on the Synthesis of Dynemicin Analogues and their Reaction Mechanisms
- Principal Investigator
  
  SHIBUYA Masayuki
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokushima
DNA認識切断機能を有するエンジインモデルの分子設計および合成研究
- Principal Investigator
  
  渋谷雅之
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
抗腫瘍性抗生物質アジノマイシンAの合成研究Principal Investigator
- Principal Investigator
  
  宍戸宏造
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokushima
ベンゾジアゼピン受容体アゴニスト活性を有するノルジテルペンの合成研究Principal Investigator
- Principal Investigator
  
  宍戸宏造
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  The University of Tokushima
Studies on The Low Toxic Antitumor Promoting Activities of Natural Products in Celastraceae Plants.
- Principal Investigator
  
  TAKAISHI Yoshihisa
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  University of Tokushima
The Development of New Drugs Possessing New Concept to Treat in Rheumatoid Arthritis Disease
- Principal Investigator
  
  TAKAISHI Yoshihisa
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  University of Tokushima
ヒッポスポンジンの合成研究Principal Investigator
- Principal Investigator
  
  宍戸宏造
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokushima
エスペラミシン系抗癌抗生物質及びモデル化合物の合成と作用機作
- Principal Investigator
  
  渋谷雅之
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokushima
分子内[2+2]環状付加反応による生理活性アルカロイドの合成研究Principal Investigator
- Principal Investigator
  
  宍戸宏造
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokushima

All 2014 2013 2012 2011 2008 2007 2004 Other

All Journal Article Presentation Book

[Book] 創薬支援研究の展望(共著)2008
- Author(s)
  宍戸宏造
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-18032052
[Book] 創薬をめざす有機合成戦略2007
- Author(s)
  宍戸宏造(編集)
- Total Pages
  201
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-18032052
[Journal Article] Concise total syntheses of heliannuols B and D2014
- Author(s)
  Yuki Manabe, Makoto Kanematsu, Hiromasa Yokoe, Masahiro Yoshida, and Kozo Shishido
- Journal Title
  
  Tetrahedron
  
  Volume: 70 Issue: 3 Pages: 742-748
- DOI
  10.1016/j.tet.2013.11.070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390026
[Journal Article] Highly efficient, enantiocontrolled total syntheses of (+)-heliannuol D and (–)-helibisabonol A2014
- Author(s)
  Yuki Manabe, Makoto Kanematsu, Mayu Osaka, Masahiro Yoshida, and Kozo Shishido
- Journal Title
  
  Heterocycles
  
  Volume: 88 Issue: 1 Pages: 441-452
- DOI
  10.3987/com-13-s(s)50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390026
[Journal Article] Enantioselective total syntheses of pygmaeocins B and C2013
- Author(s)
  Akiko Obase , Akihito Kageyama , Yuki Manabe ,Tsukasa Ozawa , Takaaki Araki , Hiromasa Yokoe ,Makoto Kanematsu , Masahiro Yoshida , and Kozo Shishido
- Journal Title
  
  Org. Lett.
  
  Volume: 15 Issue: 14 Pages: 3666-3669
- DOI
  10.1021/ol401543b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390026
[Journal Article] Regiocontrolled Construction of furo[3,2-c]pyran-4-one derivatives by palladium-catalyzed cyclization of propargylic carbonates with 4-hydroxy-2-pyrones2013
- Author(s)
  Masahiro Yoshida, Tomomi Nakagawa, Kouki Kinoshita, and Kozo Shishido
- Journal Title
  
  J. Org. Chem.
  
  Volume: 78 Pages: 1687-1692
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390026
[Journal Article] Stereocontrolled Total Synthesis of Natural Products with Characteristic Molecular Structures and Biological Activities2013
- Author(s)
  K. Shishido
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 61 Issue: 8 Pages: 781-798
- DOI
  10.1248/cpb.c13-00417
- NAID
  130003360819
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390026
[Journal Article] Total Synthesis of Aspergillides Using a Transannular Oxy-Michael Strategy2012
- Author(s)
  M. Kanematsu, K. Shishido
- Journal Title
  
  Journal of Synthetic Organic Chemistry, Japan
  
  Volume: 70 Issue: 11 Pages: 1196-1205
- DOI
  10.5059/yukigoseikyokaishi.70.1196
- NAID
  10031131199
- ISSN
  0037-9980, 1883-6526
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390026
[Journal Article] Total synthesis of the aspergillides A and B based on the transannular oxy-Michael reaction2011
- Author(s)
  M. Kanematsu, M. Yoshida, K. Shishido
- Journal Title
  
  Angew. Chem. Int. Ed
  
  Volume: vol.50 Issue: 11 Pages: 2618-2620
- DOI
  10.1002/anie.201007327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390026
[Journal Article] Efficient access to a dihydropyran containing macrolide via a transannular oxy-Michael reaction : total synthesis of (+)-aspergillide C2011
- Author(s)
  H. Kobayashi, M. Kanematsu, M. Yoshida, K. Shishido
- Journal Title
  
  Chem. Commun
  
  Volume: vol.47 Issue: 26 Pages: 7440-7442
- DOI
  10.1039/c1cc12114f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390026
[Journal Article] Total Synthes i s of (+)- and (-)-Sundiversifo目de via Intramolecular Acylation and Determination of the Absolute Configuration2008
- Author(s)
  宍戸宏造
- Journal Title
  
  Organic Letters 10
  
  Pages: 1247-1450
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18032052
[Journal Article] Pallad i um-CataIyzed Diastereoselective Coup I ing of Propargylic Oxiranes with Terminal Alkynes2007
- Author(s)
  宍戸宏造
- Journal Title
  
  Organic Letters 9
  
  Pages: 1643-1646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18032052
[Journal Article] Tota1 Synthesis of(+)-Sundiversifolide2007
- Author(s)
  宍戸宏造
- Journal Title
  
  Organic Letters 9
  
  Pages: 969-971
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18032052
[Journal Article] Synthesis of Biologically Active Natural Products Using Biocatalysts2004
- Author(s)
  K.Shishido
- Journal Title
  
  Chemical Industry 55
  
  Pages: 623-633
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209001
[Journal Article] Synthesis of Biologically Active Natural Products Using Biocatalysts2004
- Author(s)
  K.Shishido
- Journal Title
  
  Chemical Industry 55・8
  
  Pages: 623-633
- Data Source
  KAKENHI-PROJECT-16209001
[Presentation] 生物活性アルカロイドの合成研究2013
- Author(s)
  宍戸宏造
- Organizer
  第31回メディシナルケミストリーシンポジウム
- Place of Presentation
  アステールプラザ(広島県)
- Year and Date
  2013-11-21
- Data Source
  KAKENHI-PROJECT-23390026
[Presentation] 特徴ある構造と生物活性を有する天然有機化合物の立体制御全合成2013
- Author(s)
  宍戸宏造
- Organizer
  日本薬学会第133回年会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Invited
- Data Source
  KAKENHI-PROJECT-23390026
[Presentation] (+)-アスペルマイチンA の全合成2012
- Author(s)
  井上敦詞(宍戸宏造)
- Organizer
  第10回次世代を担う有機合成化学シンポジウム
- Place of Presentation
  大阪大学銀杏会館(大阪府)
- Year and Date
  2012-05-11
- Data Source
  KAKENHI-PROJECT-23390026
[Presentation] アレロケミカルに魅せられて2012
- Author(s)
  宍戸宏造
- Organizer
  第3回プロセス化学東四国フォーラムセミナー
- Place of Presentation
  徳島文理大学(徳島市)(招待講演)
- Year and Date
  2012-01-21
- Data Source
  KAKENHI-PROJECT-23390026
[Presentation] A Concise and Highly Efficient Synthesis of Allelochemicals2012
- Author(s)
  Shishido K
- Organizer
  Boss 65 Symposium
- Place of Presentation
  カリフォルニア大学ロサンゼルス校(アメリカ合衆国)
- Invited
- Data Source
  KAKENHI-PROJECT-23390026
[Presentation] Synthetic Studies on Aspergillides2011
- Author(s)
  宍戸宏造
- Organizer
  The 1st Scottish-Japanese Symposium of Organic Chemistry
- Place of Presentation
  グラスゴー大学(英国)(招待講演)
- Year and Date
  2011-09-09
- Data Source
  KAKENHI-PROJECT-23390026
[Presentation] (+)-アスパーギライドC の全合成2011
- Author(s)
  小林久剛(宍戸宏造)
- Organizer
  第100回有機合成シンポジウム
- Place of Presentation
  早稲田大学国際会議場(東京都)
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-23390026
[Presentation] 分子内Oxy-Michael反応における配座制御と天然物合成への展開2011
- Author(s)
  宍戸宏造
- Organizer
  日本薬学会東海支部特別講演会
- Place of Presentation
  名古屋市立大学(名古屋市)(招待講演)
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-23390026
[Presentation] スピロ構造を持つアレロケミカルの合成2007
- Author(s)
  宍戸宏造
- Organizer
  第42回天然物化学談話会
- Place of Presentation
  仙台市
- Year and Date
  2007-07-13
- Data Source
  KAKENHI-PROJECT-18032052
[Presentation] 生物活性アルカロイドの合成研究
- Author(s)
  宍戸宏造
- Organizer
  第３１回メディシナルケミストリーシンポジウム
- Place of Presentation
  アステールプラザ（広島県）
- Invited
- Data Source
  KAKENHI-PROJECT-23390026
[Presentation] 創薬・創農薬を指向した天然物合成
- Author(s)
  宍戸宏造
- Organizer
  日本化学会中国四国支部高知地区化学講演会
- Place of Presentation
  高知大学朝倉キャンパス（高知県）
- Invited
- Data Source
  KAKENHI-PROJECT-23390026

1. SHIBUYA Masayuki (40027066)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
2. SHINDO Mitsuru (40226345)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. TAKAISHI Yoshihisa (60035558)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 豊岡康平 (90145011)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. ITOH Kohji (00184656)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. NAKANO Kimiko (20136279)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. OTAKA Akira (20201973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SHIGENAGA Akira (10423394)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TSUJI Daisuke (00423400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HISAYAMA Tetsuhiro (70130383)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SHINOHARA Yasuo (60226157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. TERADA Hiroshi (00035544)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. FUJII Yoshiharu (10354101)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. ONO Yukihisa

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TORISAWA Yasuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SHISHIDO Kozo 宍戸 宏造

Research Projects

Research Products

Co-Researchers

Development and application of efficient identification method for drugable proteins based on natural products and bioorganic chemistriesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヘリアナンセスキテルペンのエナンチオ制御合成Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

生物活性スピロジテルペノイドの合成研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of the Environmentally Benign Agrichemicals and Novel Drug Seeds Based on Natural AllelochemicalsPrincipal Investigator

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Synthesis and Functional Analysis of Cell Adhesion Inhibitory PolyketidesPrincipal Investigator

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コンホメーション規制による新規アシルラジカル生成法の関発と機能開拓Principal Investigator

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Chemical Approach to Explicate the Molecular Mechanism for ApoptosisPrincipal Investigator

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Studies on the development of drugs for arteriosclerosis based on the inhibition of cell adhesion molecules' inductionPrincipal Investigator

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イノラートの合成と反応

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生理活性物質の合成を指向したラジカル環化プロセスの開発と展開Principal Investigator

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Studies on the Synthesis of Dynemicin Analogues and their Reaction Mechanisms

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DNA認識切断機能を有するエンジインモデルの分子設計および合成研究

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抗腫瘍性抗生物質アジノマイシンAの合成研究Principal Investigator

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SHISHIDO Kozo 宍戸宏造