SHIBUYA Masayuki 渋谷雅之

Researcher Number	40027066
Affiliation (based on the past Project Information) *help	1990 – 2003: 徳島大学, 薬学部, 教授 1988: Faculty of Pharmaceutical Sciences, the University of Tokushima, 薬学部, 教授 1987: 徳島大学, 薬学部, 助教授
Review Section/Research Field	Principal Investigator Chemical pharmacy / Science and Engineering Except Principal Investigator Chemical pharmacy / Bioorganic chemistry / Living organism molecular science
Keywords	Principal Investigator DNA / エンジイン / 切断 / 合成 / ラジカル / トリガー / エンインアレン / 芳香族 / レキシトロプシン / イオン … More / enyne-allene / synthesis / radical / エスペラミシン / 抗癌剤 / モデル化合物 / 合成化学 / ヘテロ環化合物 / 芳香環化反応 / 一重項ビラジカル / 双性イオン / ビラジカル / フェナンスリジン / スピロ環化合物 / σ-ラジカル / π-ラジカル / 酵素阻害剤 / カスケード / ダイネミシン / ビタミンB6 / enzyme-inhibition / cascade / Dynemicin / Vitamin B6 / 光学活性 / ハロゲン / enediyne / lexitropsin / optically-active / cleavage / カルジノフィリン / アジノマイシン / ネオカルチノスタチン / 抗生物質 / 化学構造 / 化学合成 / DNAの切断 / 紫外線 / 抗腫瘍活性 / NDAの切断 / 絶対配置 / Carzinophilin / Azinomycin / Neocarzinostatin / Antibiotic / Chemical Structure / Chemical Synthesis … More Except Principal Investigator DNA切断活性 / エンジイン / 全合成 / フラン / 抗腫瘍活性 / インターロイキン-1 / 慢性関節リウマチ / Masked Acyl Cyanide / umpolung / 分子内環状付加反応 / カラバル豆アルロイド / フィゾベニン / フィゾスチグミン / インド-ルアルカロイド / アルツハイマ-型痴呆症 / ビンドリン / アセチルコリンエステラ-ゼ阻害 / 海産天然物 / ヒッポスポンジン / セスタテルペン / 不斉合成 / 不斉四級炭素 / テトロン酸 / ベンゾジアゼピン / アゴニスト / 向神経薬 / 分子内付加環化 / ノルジテルペン / タンシノン / キノン / アジノマイシン / キラル合成 / 細胞毒性 / ラジカル環化 / 環拡大反応 / テルペン / リパーゼ / 光学分割 / エンインアレン / ポリオール / ビラジカル / 代謝拮抗剤 / ヌクレオシド / 抗がん剤 / アポトーシス / カスパーゼ / p53 / RNA合成阻害剤 / ドラッグデザイン / 血管新生 / リウマチ / クロズル / ニシキギ科 / トリプトキノン / 一酸化窒素 / ジテルペン / キノイド / カルス / トリテルペン / 植物組織培養 / 抗炎症 / rheumatoid arthritis / interleukin-1 / Celastraceae / Tripterygium / triptoquinone / diterpene / quinoide / NO / callus / 超原子価化合物 / 有機ヨウ素化合物 / 抗真菌活性 / アルキニルヨーダン / アルケニルヨーダン / ラジカル / 超原子価 / hypervalent compound / organoiodine / antifungal activity / alkynyliodane / alkenyliodane / DNA-cleaving activity / enediyne / radical / ペプチドミミック / 筋肉衰退抑制 / 高齢者社会への対応 / 宇宙時代への対応 / ユビキチン / MAC反応剤 / アシルアニオン等価体 / peptide mimics / ubiquitin / correspondence of an aging society / correspondence of the space age / inhibition effect of reducing musclar strength Less

Design, synthesis and property of peptide mimics having inhibition effect of reducing musclar strength
- Principal Investigator
  
  NEMOTO Hisao
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  The University of Tokushima
芳香環化反応を鍵反応とする複素環化合物の新規合成法の開発Principal Investigator
- Principal Investigator
  
  渋谷雅之
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokushima
Development of Anticancer Agents Based on Photochemical DNA-CleavagePrincipal Investigator
- Principal Investigator
  
  SHIBUYA Masayuki
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokushima
ドラッグデザインによる新しい抗がん剤の合成
- Principal Investigator
  
  松田彰
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Hokkaido University
エンジイン系DNAダメージング分子の構築Principal Investigator
- Principal Investigator
  
  渋谷雅之
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokushima
エンジイン系DNAダメージング分子の構築Principal Investigator
- Principal Investigator
  
  渋谷雅之
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokushima
Molecular Design of Hypervalent Iodine and Development of Drugs
- Principal Investigator
  
  OCHIAI Masahito
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokushima University
DNA認識切断機能を有するエンジインモデルの分子設計および合成研究Principal Investigator
- Principal Investigator
  
  渋谷雅之
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
生理活性物質の合成を指向したラジカル環化プロセスの開発と展開
- Principal Investigator
  
  宍戸宏造
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokushima
エンジイン系化合物のカスケード型ポリグリセロールによる水溶性制御
- Principal Investigator
  
  NEMOTO Hisao
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokushima
DNA認識切断機能を有するエンジインモデルの分子設計および合成研究Principal Investigator
- Principal Investigator
  
  渋谷雅之
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
Studies on the Synthesis of Dynemicin Analogues and their Reaction MechanismsPrincipal Investigator
- Principal Investigator
  
  SHIBUYA Masayuki
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokushima
DNA認識切断機能を有するエンジインモデルの分子設計および合成研究Principal Investigator
- Principal Investigator
  
  渋谷雅之
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
抗腫瘍性抗生物質アジノマイシンAの合成研究
- Principal Investigator
  
  宍戸宏造
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokushima
ベンゾジアゼピン受容体アゴニスト活性を有するノルジテルペンの合成研究
- Principal Investigator
  
  宍戸宏造
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  The University of Tokushima
The Development of New Drugs Possessing New Concept to Treat in Rheumatoid Arthritis Disease
- Principal Investigator
  
  TAKAISHI Yoshihisa
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  University of Tokushima
ヒッポスポンジンの合成研究
- Principal Investigator
  
  宍戸宏造
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokushima
エスペラミシン系抗癌抗生物質及びモデル化合物の合成と作用機作Principal Investigator
- Principal Investigator
  
  渋谷雅之
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokushima
分子内[2+2]環状付加反応による生理活性アルカロイドの合成研究
- Principal Investigator
  
  SHISHIDO Kozo
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokushima
Synthesis of Antitumor Antibiotics and their Model CompoundsPrincipal Investigator
- Principal Investigator
  
  SHIBUYA Masayuki
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokushima

All 2005 2004 2003

All Journal Article

[Journal Article] Synthesis of a water-soluble molecular tweezer and a recognition study in an aqueous media2005
- Author(s)
  Nemoto, Hisao, Kawano, Tomoaki, Ueji, Nobuo, Sakamoto, Nobutaka, Araki, Takaaki, Miyoshi, Norikazu, Suzuki, Ichiro, Shibuya, Masayuki
- Journal Title
  
  Tetrahedron Lett. 46
  
  Pages: 551-553
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510177
[Journal Article] Highly efficient chiral resolution and determination of absolute configuration of 2-alkanols by using a cyclopenta[b]furan derivative2004
- Author(s)
  Nemoto, Hisao, Tsutsumi, Hiroe, Yuzawa, Satomi, Peng, Xian, Zhong, Weihui, Xie, Jun, Miyoshi, Norikazu, Suzuki, Ichiro, Shibuya, Masayuki
- Journal Title
  
  Tetrahedron Lett. 45
  
  Pages: 1667-1670
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510177
[Journal Article] Synthesis and DNA damaging ability of enediyne model compounds possessing photo-triggering devices2004
- Author(s)
  Suzuki, Ichiro, Uno, Shinsaku, Tsuchiya, Yuko, Shigenaga, Akira, Nemoto, Hisao Shibuya, Masayuki
- Journal Title
  
  Bioorg.Med.Chem.Lett. 14
  
  Pages: 2959-2962
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510177
[Journal Article] Developments of enediyne model compounds generating biradicals with an enhanced radical character-regulation of triggering devices2004
- Author(s)
  Suzuki, Ichiro, Shigenaga, Akira, Nemoto, Hisao, Shibuya, Masayuki
- Journal Title
  
  Heterocycles 62
  
  Pages: 503-519
- NAID
  80016354293
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510177
[Journal Article] Synthesis and DNA damaging ability of enediyne-polyamine conjugates2004
- Author(s)
  Suzuki, Ichiro, Shigenaga, Akira, Nemoto, Hisao, Shibuya, Masayuki
- Journal Title
  
  Tetrahedron Lett. 45
  
  Pages: 1955-1959
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510177
[Journal Article] Synthesis, reactions and DNA damaging abilities of 10-membered enediyne-sulfone and related compounds2003
- Author(s)
  Suzuki, Ichiro, Shigenaga, Akira, Manabe, Atsuo, Nemoto, Hisao, Shibuya, Masayuki
- Journal Title
  
  Tetrahedron 59
  
  Pages: 5691-5704
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510177

1. SHISHIDO Kozo (20006349)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
2. TOYOOKA Kouhei (90145011)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. NEMOTO Hisao (30208293)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
4. TAKAISHI Yoshihisa (60035558)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SUZUKI Ichiro (40294714)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. NAKANO Kimiko (20136279)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OCHIAI Masahito (50127065)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NIKAWA Takeshi (20263824)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KUBOTA Seiju (60035532)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 松田彰 (90157313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 綿矢有佑 (90127598)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 関根光男 (40111679)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 佐々木琢磨 (90109976)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. ONO Yukihisa

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. OONO Sachio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. YAMADA Yuji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SHIBUYA Masayuki 渋谷 雅之

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芳香環化反応を鍵反応とする複素環化合物の新規合成法の開発Principal Investigator

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Review Section

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Development of Anticancer Agents Based on Photochemical DNA-CleavagePrincipal Investigator

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エンジイン系DNAダメージング分子の構築Principal Investigator

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エンジイン系DNAダメージング分子の構築Principal Investigator

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DNA認識切断機能を有するエンジインモデルの分子設計および合成研究Principal Investigator

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DNA認識切断機能を有するエンジインモデルの分子設計および合成研究Principal Investigator

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Studies on the Synthesis of Dynemicin Analogues and their Reaction MechanismsPrincipal Investigator

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DNA認識切断機能を有するエンジインモデルの分子設計および合成研究Principal Investigator

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SHIBUYA Masayuki 渋谷雅之