SEKINE MITSUO 関根光雄

… Alternative Names

SEKINE Mitsuo 関根光雄

関根光男セキネミツオ

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Researcher Number	40111679
Other IDs
Affiliation (based on the past Project Information) *help	2012 – 2014: 東京工業大学, 生命理工学研究科, 教授 2009 – 2011: Tokyo Institute of Technology, 大学院・生命理工学研究科, 教授 2001 – 2004: Tokyo Institute of Technology, Department of Life Science, Dr. Sc., 大学院・生命理工学研究科, 教授 2000: 東京工業大学, 大学院・生命理工学研究所, 教授 1999: 東京工業大学, 大学院・生命理工学研究科, 教授 … More 1999: 東工大, 生命理工学部, 助教授 1990 – 1998: 東京工業大学, 生命理工学部, 助教授 1990: 東工大, 生命理工学部, 助教授 1989: 東京工業大学, 理学部生命理学科, 助教授 1988: 東京工業大学, 大学院・総合理工, 講師 1988: 東京工業大学, 大学院総合理工学研究科, 講師 1987: 東京工業大学, 大学院・総合理工学研究所, 助手 1987: The Graduate School at Nagatsuta. T.I.T. Associate, 大学院総合理工学研究所, 助手 1986: 東京工業大学, 総合理工学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Bioorganic chemistry / 天然物有機化学 / Living organism molecular science / 広領域 / Molecular biology / Biomolecular chemistry / Bio-related chemistry / Science and Engineering Except Principal Investigator Chemical pharmacy / 天然物有機化学 / Chemistry / 科学教育(含教育工学)
Keywords	Principal Investigator RNA / tRNA / SOLID PHASE SYNTHESIS / 固相合成 / コンホメーション / ANTISENCE NUCLEIC ACID / HIV / 筋ジストロフィー / 固相合成法 / フェロセン … More / シクロウリジル酸 / 3'-endo / 遺伝子治療 / ベント構造 / 水素結合 / アンチコドン / AMIDITE / ENZYME RESISTANCE / 2'-PHOSPHATE / アンチセンス核酸 / 酵素耐性 / RNAの化学合成 / アミダイトユニット / 塩基対形成能 / 人工核酸 / アンチジーン法 / 核酸医薬 / 2'-O-MCE-RNA / マイナーグルーブバインダー / リン酸トリエステル / 立体異性体 / アンチセンス / 分子力場計算 / PNA / ペプチド核酸 / コドン / Uターン構造 / リン酸化 / なげなわ構造 / 保護基 / OLIGODEOXYNUCLEOTIDE / PHOSPHORAMIDITE METHOD / LINKER / PROTECTING GROUP / ACTIVATOR / NUCLEOBASE / DNA CHEMICAL SYNTHESIS / 溶媒効果 / ン-メチルピロリドン / キャップ化反応 / DNAの化学合成 / ホスファチル化 / プロントンブロック法 / 塩基部位無保護DNA合成法 / プロトンブロック法 / DNAチップ / 遺伝子診断 / 修飾DDNA / 活性ホスファイト法 / 塩基部無保護DNAの化学合成 / U1 RNA / 2-AZIDODEOXYADENOSINE / SOLID PHASE / PHOTOCROSSLINKING / TRANSFER RNA SYNTHESIS / SYNTHETIC / MODIFIED RNA / ANTISENCE NUCLEIC ACID RNA / 縮合反応 / ホスホネート法 / アミダイト法 / 6-チオグアノシン / 6-チオイノシン / 4-チオウリジン / U1RNA / 2-アジドデオイシアデノシン / 光クロスリンク / 合成RNA / 修飾RNA / DUPLEX FORMATION / MOLECULAR MECHANICS / INTRAMOLECULAR CYCLIZATION / CYCLOURIDYLIC ACID / 3'-ENDO / CONFORMATION / H-ホスホネートDNA / 分子内水素結合 / シクロヌクレオチド / 3′-endo / 二重らせん形成 / 分子内環状化反応 / CHEMICAL SYNTHESIS / リンカー / ジホスフェート / 塩基配列決定法 / 標識 / ビオチン / 化学発光 / CHEMICALSYNTHESIS / チオリン酸基 / 2'、3'-リン酸基転移 / 環状シリルエーテル / エイズ / アミダイト試薬 / 2'-リン酸化RNA / 酸素耐性 / アミダイト / 固相法 / 化学合成 / 2'-リン酸 / アンチ核酸 / オリゴヌクレオチド合成 / 環状RNA / ペプチド / ポリオウィルス / ヌクレオチドプロテイン / 光延反応 / 遺伝暗号拡張 / トリリン酸化 / 人工塩基 / DNAポリメラーゼ / 新規塩基対 / （ピロール-2-イル）カルボニル基 / 2,6-ジアミノプリン / ホスホロチオエートRNA / ２ーチオチミン / 2-チオウラシル / エキソンスキッピング / 2'-O-修飾RNA / グアノシン / アデノシン / 合成モノマーユニット / 脱アミノ化反応 / シアノエチル化 / 2'-保護基 / マイケル反応 / 塩基部無保護 / 2'水酸某の保護基 / MCE基 / シアノエチル基 / Michael反応 / RNA医薬 / 2'水酸基の保護基 / RNA合成 / 生体高分子 / 修飾塩基 / 2重鎖熱融解曲線 / 分子設計 / 塩素対形成能 / 分子動力学的解析 / Activator 42 / 塩基識別能 / 相間移動触媒反応 / マイクロフロー合成 / 修飾RNA合成 / ３重鎖形成核酸 / ホスホロチオエート / 筋ジストロフィー医薬 / エキソン・スキッピング / マイクロフロー系反応 / 三重鎖形成核酸 / 連続的固相合成 / TMGキャップ構造 / 集積合成 / RNA transcript / trimethylguanosine cap / muscular dystrophy / U1snRNA / マイクロフロー / 連続合成 / 二重分子識別 / 遺伝子診断法 / ポリアミド / DNA2重らせん / 電気化学的酸化還元反応 / Dervan則 / 固相担体 / mRNA検出法 / 塩基対 / 遺伝診断 / DNAプローブ / シランジイル型のスペーサー / 非W-C型DNA2重らせん / N-アシル型DNA / ミスマッチ / 電気化学応答 / 2重分子認識 / 塩基配列認識 / ホリアミド分子 / イミダゾール / ピロール / マイナーグルーブ / 4-N-メトキシカルボニルシチジン / 抗C型肝炎ウイルス剤 / HCVの代替ウィルス / ブレディニン / 増殖阻害 / 3'-Ο-BDTチミジ / BVDV / 人工RNA / ハイブリダイセーション / 電気化学的遺伝子検出法 / DNA検出法 / 二重分子識別原理 / 2-チオウラシル塩基 / 塩基対水素結合 / ab initio計算 / rRNA / 環状ウリジル酸 / ハイブリダイゼーション / がん / ベントRNA / U-ターン構造 / スペーサー / 核酸の化学合成 / NMR / 脱保護 / 分岐構造 / イントロン / スプライシング / 機能性DNA / カルバモイルホスホネ-ト / メチル化 / アンチセンスDNA … More Except Principal Investigator アンチセンス核酸 / 構造 / 核酸 / CMP-Neu5Ac / ヌクレオシド / RNAの化学合成 / 遺伝子 / 分子設計 / 有機化学 / 機能 / RNA / DNA / 分岐RNA / グリコシル化反応 / 抗HIV活性 / 炭素環ヌクレオシド / オリゴヌクレオチド / Phosphorylation / Phosphotriester Approach / Branched RNA / Lariat Structure / リン酸化 / リン酸トリエステル法 / 投げなわ構造 / N-acylated DNA / H-phosphonate method / telomere / oxanosine / azole complex / acid / allyl protection / phosphoramidite method / 塩基配列認識ペプチド / 一酸化窒素による発ガン / DNA-ペプチドコンジュゲート / アリル保護アミダイト法 / 修飾DNAオリゴマー / 塩基部無保護アミダイト法 / 分子認識能 / 塩基対形成能 / N-アシルDNA / クロスリンク / 遺伝子傷害 / RNAオリゴマー / 一酸化窒素 / 2-5A / デオキシオキザノシン / CMP-New5Ac / ヌクレオチド化学合成 / N-アシル化DNA / H-ホスホネート法 / テロメア / オキザノシン / アゾール複合体 / 酸 / アリル保護法 / ホスホロアミダイト法 / Scientific and technological text books for reading comprehenshion / Lecturs on science and technology in Japanese / Discourse analysis / Syntactic analysis / Particles equivalents / Frequency of c hinese characters / Vocabulary survey / Text data base of science and technology / CAI / 学習行動分析 / ニ-ズアナリシス / 頻度解析プログラム / デ-タベ-ス入力 / 専門日本語講義 / 形態素解析 / 理工系大学テキスト / ディスコーテ分析 / 科学技術文章読解教科書 / 科学技術日本語講義 / ディスコース分析 / 構文解析 / 助詞相当句 / 漢字頻度 / 語彙調査 / 理工系大学テキストデータベース / 核酸の化学合成 / エンジイン / 血管新生 / ドラッグデザイン / RNA合成阻害剤 / p53 / カスパーゼ / アポトーシス / 抗がん剤 / 代謝拮抗剤 / 核酸水素給合 / 核酸合成 / 核酸高次構造 / 機能性核酸 / NMR / 核酸有機化学 / 核酸構造 / フローサイトメトリー / 転移反応 / 2'-リン酸化RNA / 塩基特異性 / ルイス酸 / CNDAC / 投げ縄構造 / C-myb protooncogene / β-ヌクレオシド / 核酸塩基 / アデノシンデアミナーゼ / 抗腫瘍性 / ディスタマイシン / ブレオマイシン / レトロアルド-ル反応 / リボザイム Less

Development of the ultimate third nucleobase required for expansion of the genetic codePrincipal Investigator
- Principal Investigator
  
  SEKINE Mitsuo
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Tokyo Institute of Technology
筋ジストロフィー治療薬を目指した新規人工核酸の合成Principal Investigator
- Principal Investigator
  
  関根光雄
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Tokyo Institute of Technology
Sequential synthesis of functional synthetic nucleic acidsPrincipal Investigator
- Principal Investigator
  
  SEKINE MITSUO
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Tokyo Institute of Technology
Exploration of Innovative Methods for the synthesis of RNA Capable of Machting Requirement for New dayPrincipal Investigator
- Principal Investigator
  
  SEKINE Mitsuo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Living organism molecular science
- Research Institution
  Tokyo Institute of Technology
二重分子識別原理に基づく新しい高精度DNA/RNA検出法Principal Investigator
- Principal Investigator
  
  関根光雄
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Institute of Technology
二重分子識別原理に基づく新しい高精度DNA/RNA検出法Principal Investigator
- Principal Investigator
  
  関根光雄
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Institute of Technology
非天然型DNA2重らせんの創成Principal Investigator
- Principal Investigator
  
  関根光雄
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Living organism molecular science
- Research Institution
  Tokyo Institute of Technology
ベント構造を利用する新しい高精度DNA/RNA検出法Principal Investigator
- Principal Investigator
  
  関根光雄
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Institute of Technology
抗C型肝炎ウイルス活性をもつ新しいヌクレオシド誘導体の合成と活性評価Principal Investigator
- Principal Investigator
  
  関根光雄
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Institute of Technology
EXPLORATION OF ULTIMATE NEW SYNTHETIC METHOD OF DNA/RNA BY USE OF "PROTON-BLOCK APPROACH"-DIRECTED TOWARD ESTABLISHMENT OF INOVATIVE METHOD FOR THE SYNTHESIS OF NUCLEIC ACIDS WITHOUT BASE PROTECTION-Principal Investigator
- Principal Investigator
  
  SEKINE Mitsuo
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  TOKYO INSTITUTE OF TECHNOLOGY
ドラッグデザインによる新しい抗がん剤の合成
- Principal Investigator
  
  松田彰
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Hokkaido University
5’水酸基と3’リン酸基の同時保護法による核酸の化学合成Principal Investigator
- Principal Investigator
  
  関根光雄
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Tokyo Institute of Technology
Basic Research for the Creation of Artificial Nucleic Acids and Related Biomolecules with Useful Functions
- Principal Investigator
  
  HAYAKAWA Yoshihiro
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Chemistry
- Research Institution
  Nagoya University
tRNAに存在する特異な構造モチーフの分子固定と構造解析Principal Investigator
- Principal Investigator
  
  関根光雄
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology
ベント構造をもつ核酸の化学合成Principal Investigator
- Principal Investigator
  
  関根光雄
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Tokyo Institute of Technology
tRNAアンチコドン部位のコンホメーションの人工固定化およびその分子認識能Principal Investigator
- Principal Investigator
  
  関根光雄
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology
がん遺伝子に特異的に結合できるペプチド核酸を用いる新しいがん治療法Principal Investigator
- Principal Investigator
  
  関根光雄
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology
MOLECULAR DESIGN OF NEW EFFECTIVE ANTISENSE NUCLEIC ACIDS CAPABLE OF HYBRIDIZATION TO THE TARGET NENESPrincipal Investigator
- Principal Investigator
  
  SEKINE Mitsuo
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  TOKYO INSTITUTE OF TECHNOLOGY
DEVELOPMENTS OF THE METHOD FOR THE CHEMICAL SYNTHESIS OF RNA CONTAINING MODIFIED BASED" -DIRECTED TOWARD FULL AUTOMATION OF RNA CONTAINING MODIFIED BASES BY USE OF NEW SYNTHETIC UNITS-Principal Investigator
- Principal Investigator
  
  SEKINE Mitsuo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  広領域
- Research Institution
  TOKYO INSTITUTE OF TECHNOLOGY
tRNAアンチコドン部位のコンホメーションの人工的固定化およびその分子認識能Principal Investigator
- Principal Investigator
  
  関根光雄
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology
がん遺伝子に特異的に結合できるペプチド核酸を用いる新しいがん治療法-高ハイブリダイゼーション能力をもつ新素材分子の可能性-Principal Investigator
- Principal Investigator
  
  関根光雄
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology
特異な構造をもつヌクレオシドの化学合成と反応
- Principal Investigator
  
  金子主税
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
tRNAアンチコドン部位のコンホメーションの人工的固定化およびその分子認識能Principal Investigator
- Principal Investigator
  
  関根光雄
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology
CHEMICAL SYNTHESIS OF A NEW MATERIAL OF ANTISENSE NUCLEIC ACID "2'-PHOSPHORYLATED RNAS" -DIRECTED TOWARD ITS BASIC STRUCTURAL STUDIES AND REGULATION OF EXPRESSION OF HIV VIRUS-Principal Investigator
- Principal Investigator
  
  SEKINE Mitsuo
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Molecular biology
- Research Institution
  TOKYO INSTITUTE OF TECHNOLOGY
核酸の構造と機能の有機化学的展開(成果とりまとめ)
- Principal Investigator
  
  畑辻明
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology
アンチセンス核酸の活性と水素結合の機能の研究
- Principal Investigator
  
  大塚栄子
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Hokkaido University
CHEMICAL SYNTHESIS OF A NEW MATERIAL OF ANTISENSE NUCLEIC ACID"2"PHOSTHORYLATEDRNAS" DIRETED TOWARD IIS BASIC STRUCTRAL STUDIES AND REGULATION OF EXPRESSION OF HIV VIRUS-Principal Investigator
- Principal Investigator
  
  SEKINE Mitsuo
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  天然物有機化学
- Research Institution
  TOKYO INSTITUTE OF TECHNOLOGY
特異な構造をもつヌクレオシドの化学合成と反応
- Principal Investigator
  
  金子主税
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
核酸の構造と機能の有機化学的展開
- Principal Investigator
  
  畑辻明
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology
特異な分岐構造をもつ核酸の化学合成と機能Principal Investigator
- Principal Investigator
  
  関根光雄
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology
核酸の構造と機能の有機化学的展開
- Principal Investigator
  
  HATA Tsujiaki
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Institution
  Tokyo Institute of Technology
Development of Japanese textbooks for Science and Technology
- Principal Investigator
  
  NISHINA Kikuko
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  科学教育(含教育工学)
- Research Institution
  Education Center for Foreign Student;Tokyo Institute of Technology
標的遺伝子の選択的不活性化機能をもつアンチセンスDNAの設計と合成Principal Investigator
- Principal Investigator
  
  関根光雄
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  天然物有機化学
- Research Institution
  Tokyo Institute of Technology
核酸および核酸構成成分の合成と生体機能に関する研究
- Principal Investigator
  
  畑辻明
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo Institute of Technology
投げなわ構造をもつRNA分子の2'-5'結合を含む環状RNAの構築反応Principal Investigator
- Principal Investigator
  
  関根光雄
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  天然物有機化学
- Research Institution
  Tokyo Institute of Technology
ペプチド側鎖に共有結合したRNAオリゴマーの化学合成に関する基礎的研究Principal Investigator
- Principal Investigator
  
  関根光雄
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  天然物有機化学
- Research Institution
  Tokyo Institute of Technology
Chemical Synthesis of RNAs Containing Lariat Structure
- Principal Investigator
  
  HATA Tsujiaki
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  天然物有機化学
- Research Institution
  Tokyo Institute of Technology

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All Journal Article Presentation Book

[Book] Synthesis and Exon-Skipping Assay of Chemically Modified RNAs, in RNA Technologies: DNA and RNA Chemical Biology in Science and Medicine, ed. V. A. Erdmann, W. T. Markiewicz, and J. Barciszewski. Chaptor 192014
- Author(s)
  Y. Masaki, T. Yamada, H. Saneyoshi, A. Ohkubo, K. Seio, and M. Sekine
- Data Source
  KAKENHI-PLANNED-21106007
[Journal Article] A new modified cytosine base capable of base pairing with guanine using four hydrogen bonds2014
- Author(s)
  Yamada, K.; Masaki, Y.; Tsunoda, H.; Ohkubo, A.; Seio, K.;Sekine, M
- Journal Title
  
  Org. Biomol. Chem
  
  Volume: 12 Pages: 2255-2262
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007
[Journal Article] Properties of 5- and/or 2-modified 2'-O-cyanoethyl uridine residue: 2'-O-cyanoethyl-5-propynyl-2-thiouridine as an efficient duplex stabilizing component.2014
- Author(s)
  Masaki Y, Miyasaka R, Hirai K, Kanamori T, Tsunoda H, Ohkubo A, Seio K, Sekine M
- Journal Title
  
  Org Biomol Chem.
  
  Volume: 12 Issue: 7 Pages: 1157-1162
- DOI
  10.1039/c3ob41983e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24550184, KAKENHI-PROJECT-25288074
[Journal Article] Development of New Methods for Synthesis of Artificial Nucleic Acids having Various Functional Groups2014
- Author(s)
  Ohkubo, Akihiro; Seio, Kohji; Sekine, Mitsuo
- Journal Title
  
  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN
  
  Volume: 72 Pages: 899-909
- NAID
  130004691490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25288074
[Journal Article] Properties of 5- and/or 2-modified 2'-O-cyanoethyl uridine residue: 2'-O-cyanoethyl-5-propynyl-2-thiouridine as an efficient duplex stabilizing component.2014
- Author(s)
  Yamada K, Masaki Y, Tsunoda H, Ohkubo A, Seio K, Sekine M.
- Journal Title
  
  Org Biomol Chem.
  
  Volume: 12 Issue: 14 Pages: 1157-62
- DOI
  10.1039/c3ob42420k
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007, KAKENHI-PROJECT-24550184
[Journal Article] Synthesis and properties of oligonucleotides modified with 2'-O-(2-carboxyethyl)nucleotides and their carbamoyl derivatives.2014
- Author(s)
  Yamada T, Masaki Y, Okaniwa N, Kanamori T, Ohkubo A, Tsunoda H, Seio K, Sekine M
- Journal Title
  
  Org Biomol Chem.
  
  Volume: 12 Issue: 33 Pages: 6457-6464
- DOI
  10.1039/c4ob01260g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24550184, KAKENHI-PROJECT-25288074, KAKENHI-PROJECT-26810086
[Journal Article] Properties of 5-and/or 2-modified 2'-O-cyanoethyl uridine residue: 2'-O-cyanoethyl-5-propynyl-2-thiouri dine as an efficient duplex stabilizing component2014
- Author(s)
  Masaki, Y.; Miyasaka, R.;Hirai, K.;Kanamori, T.; Tsunoda, H.; Ohkubo, A.; Seio, K.; Sekine, M
- Journal Title
  
  Org. Biomol. Chem
  
  Volume: 12 Pages: 1157-1162
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007
[Journal Article] Base recognition of gap sites in DNA-DNA and DNA-RNA duplexes by short oligonucleotides2013
- Author(s)
  Yamada, K.;Ohkubo, A.; Esaka, Y.; Kanamori, T.;Masaki, Y.;Seio, K.;Sekine, M. Bioorg
- Journal Title
  
  Med. Chem. Lett
  
  Volume: 23 Pages: 3448-3451
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007
[Journal Article] Remarkable stabilization of antiparallel DNA triplexes by strong stacking effects of consecutively modified nucleobases containing thiocarbonyl groups.2013
- Author(s)
  Yamada K, Hattori Y, Inde T, Kanamori T, Ohkubo A, Seio K, Sekine M.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 23 Issue: 3 Pages: 776-8
- DOI
  10.1016/j.bmcl.2012.11.079
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007, KAKENHI-PROJECT-24550184, KAKENHI-PROJECT-25288074
[Journal Article] Chemical Synthesis of UlsnRNA Derivatives2013
- Author(s)
  Ohkubo, A.; Kondo, Y.; Suzuki, M.;Kobayashi, H.;Kanamori, T.; Masaki, Y.; Seio, K.; Nagai, K.; Sekine, M
- Journal Title
  
  Org. Lett
  
  Volume: 15 Issue: 17 Pages: 4386-4389
- DOI
  10.1021/ol401917r
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007, KAKENHI-PROJECT-24550184, KAKENHI-PROJECT-25288074
[Journal Article] Base recognition of gap sites in DNA-DNA and DNA-RNA duplexes by short oligonucleotides.2013
- Author(s)
  Yamada K, Ohkubo A, Esaka Y, Kanamori T, Masaki Y, Seio K, Sekine M.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 23 Issue: 11 Pages: 3448-51
- DOI
  10.1016/j.bmcl.2013.03.054
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007, KAKENHI-PROJECT-24550184, KAKENHI-PROJECT-25288074
[Journal Article] Remarkable stabilization of antiparallel DNA triplexes by strong stacking effects of consecutively modified nucleobases containing thiocarbonyl groups2013
- Author(s)
  Yamada, K.; Hattori, Y.; Inde, T.; Kanamori, T.; Ohkubo, A.; Seio, K.; Sekine, M. Bioorg
- Journal Title
  
  Med. Chem. Lett
  
  Volume: 23 Pages: 776-778
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007
[Journal Article] Fluorescent properties of oligonucleotides doubly modified with an indole-fused cytosine analog and 2-aminopurine2013
- Author(s)
  Seio, K.; Kanamori, T.;Tokugawa, M.;Ohzeki, H.;Masaki, Y.; Tsunoda, H.; Ohkubo, A.; Sekine, M. Bioorg
- Journal Title
  
  Med. Chem
  
  Volume: 21 Pages: 3197-3201
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007
[Journal Article] Modified oligodeoxynucleotide primers for reverse-transcription of target RNAs that can discriminate among length variants at the 3'-terminus2013
- Author(s)
  Iijima, Y.;Kojima, S.; Kodama, E.; Kurohagi, S.; Kanamori, T.; Masaki, Y.; Ohkubo, A.; Sekine, M.;Seio, K
- Journal Title
  
  Org. Biomol. Chem
  
  Volume: 11 Pages: 8276-8282
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007
[Journal Article] Prediction of the stability of modified RNA duplexes based on deformability analysis: 0ligoribonucleotide derivatives modified with 2'O-cyanoethyl- 5-propynyl-2-thiouridine as a promising component2012
- Author(s)
  Masaki, Y.; Miyasaka, R.;Hirai, K.;Tsunoda, H.; Ohkubo, A.;Seio, K.;Sekine, M
- Journal Title
  
  Chem. Commun
  
  Volume: 48 Issue: 58 Pages: 7313-7315
- DOI
  10.1039/c2cc33409g
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007, KAKENHI-PROJECT-24550184
[Journal Article] Synthesis of 5'-Terminal Capped Oligonucleotides Using O-N Phosphoryl Migration of Phosphoramidite Derivatives2012
- Author(s)
  Ohkubo, A.;Tago, N.;Nishino, Y.;Yamada, K.; Tsunoda, H.:Seio, K.:Sekine, M
- Journal Title
  
  Org. Lett
  
  Volume: 14 Issue: 1 Pages: 10-13
- DOI
  10.1021/ol2026075
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007, KAKENHI-PROJECT-24550184
[Journal Article] Development of an Efficient Method for Phosphorodiamidate Bond Formation by Using Inorganic Salts2012
- Author(s)
  Harakawa, T.; Tsunoda, H.; Ohkubo, A.;Seio, K.;Sekine, M. Bioorg
- Journal Title
  
  Med. Chem. Lett
  
  Volume: 22 Pages: 1445-1447
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007
[Journal Article] DNA Duplexes and Triplex-Forming Oligodeoxynucleotides Incorporating Modified Nucleosides Forming Stable and Selective Triplexes2012
- Author(s)
  T. Kanamori, Y. Masaki, M. Mizuta, H. Tsunoda, A. Ohkubo, M. Sekine, and K. Seio
- Journal Title
  
  Org. Biomol. Chem
  
  Volume: 10巻 Pages: 1007-1013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Synthesis and Properties of Cationic 2'-O-[ N-(4-aminobutyl) carbamoyl] modified Oligonucleotides.2012
- Author(s)
  K. Seio, M. Tokugawa, T. Kanamori, H. Tsunoda, A. Ohkubo, and M. Sekine
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 22巻 Pages: 2470-2473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] DNA Duplexes and Triplex-Forming Oligodeoxynucleotides Incorporating Modified Nucleosides Forming stable and Selective Triplexes2012
- Author(s)
  Kanamori, T.; Masaki, Y.; Mizuta, M.; Tsunoda, H.; Ohkubo, A.; Sekine, M.; Seio, K.
- Journal Title
  
  Org.Biomol.Chem
  
  Volume: 10 Issue: 5 Pages: 1007-1013
- DOI
  10.1039/c1ob06411h
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007, KAKENHI-PROJECT-21241053
[Journal Article] Formation of New Base Pairs between Inosine and 5-Methyl-2-thiocytidine Derivatives2012
- Author(s)
  Ohkubo, A.; Nishino, Y.; Ito, Y.; Tsunoda, H.; Seio, K.; Sekine
- Journal Title
  
  Org.Biomol.Chem.
  
  Volume: 10 Issue: 10 Pages: 2008-2010
- DOI
  10.1039/c2ob06641f
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007, KAKENHI-PROJECT-21241053, KAKENHI-PROJECT-22750146, KAKENHI-PROJECT-24550184
[Journal Article] Formation of New Base Pairs between Inosine and 5-Methyl-2-thiocytidine Derivatives2012
- Author(s)
  A. Ohkubo, Y. Nishino, Y. Ito, H. Tsunoda, K. Seio, and M. Sekine
- Journal Title
  
  Org. Biomol. Chem
  
  Volume: 10巻 Pages: 10-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Formation of New Base Pairs between Inosine and 5-Methyl-2-thiocytidine Derivatives2012
- Author(s)
  Ohkubo, A.;Nishino, Y.; Ito, Y.;Tsunoda, H.;Seio, K.;Sekine, M
- Journal Title
  
  Org. Biomol. Chem
  
  Volume: 10 Pages: 2008-2010
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007
[Journal Article] Synthesi and Properties of Cationic 2'-O-[N-(4-aminobutyl)carbamoyl]modified Oligonucleotides2012
- Author(s)
  Seio, K.; Tokugawa, M.; Kanamori, T.; Tsunoda, H.; Ohkubo, A.; Sekine, M
- Journal Title
  
  Bioorg.Med.Chem.Lett
  
  Volume: 22 Pages: 2470-2473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Synthesis and Properties of Cationic 2'O-[N-(4-aminobutyl)carbamoyl]- modified Oligonucleotides2012
- Author(s)
  Seio, K.; Tokugawa, M.; Kanamori, T.; Tsunoda, H.;Ohkubo, A.;Sekine, M. Bioorg
- Journal Title
  
  Med. Chem. Lett
  
  Volume: 22 Pages: 2470-2473
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007
[Journal Article] Synthesis and Properties of Cationic 2'-O-[N-(4-aminobutyl)carbamoyl]modified Oligonucleotides2012
- Author(s)
  Seio, K.; Tokugawa, M.; Kanamori, T.; Tsunoda, H.; Ohkubo, A.; Sekine, M
- Journal Title
  
  Bioorg.Med.Chem.Lett
  
  Volume: 22 Pages: 2470-2473
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007
[Journal Article] Short-RNA Selective Binding of Oligonucleotides Modified Using Adenosine and Guanosine Derivatives That Possess Cyclohexyl Phosphates as Substituents2012
- Author(s)
  Seio, K.; Kurohagi, S.;Kodama, E.;Tsunoda, H.;Ohkubo, A.; Sekine, M
- Journal Title
  
  Org. Biomol. Chem
  
  Volume: 10 Pages: 994-1006
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007
[Journal Article] DNA Duplexes and Triplex-Forming Oligodeoxynucleotides Incorporating Modified Nucleosides Forming Stable and Selective Triplexes2012
- Author(s)
  T.; Masaki, Y.; Mizuta, M.; Tsunoda, H.;Ohkubo, A.;Sekine, M.;Seio, K
- Journal Title
  
  Org. Biomol. Chem
  
  Volume: 10 Pages: 1007-1013
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007
[Journal Article] Synthesis and Properties of Oligoribonucleotides Having 5'-Terminal 2,2,7-Trimethylguanosine Cap Analogues2011
- Author(s)
  Ohkubo, A.;Yokouchi, A.;Yamada, K.;Tsunoda, H.;Seio, K.; Sekine, M
- Journal Title
  
  Nucleic Acids Therapeutics
  
  Volume: 21 Issue: 5 Pages: A1-A64
- DOI
  10.1089/nat.2011.1502
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007
[Journal Article] Synthesis of 2'-O-[ 2-(N-Methylcarbamoyl) ethyl] ribonucl eosides Using Oxa-Michael Reaction and Chemical and Biological Properties of Oligonucleotide Derivatives Incorporating These Modified Ribonucleosides2011
- Author(s)
  T. Yamada, N. Okaniwa, H. Saneyoshi, A. Ohkubo, K. Seio, T. Nagata, Y. Aoki, S. Takeda, and M. Sekine
- Journal Title
  
  J. Org. Chem
  
  Volume: 76巻 Pages: 3042-3053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Synthesis and Hybridization Properties of 2'-O-Methylated Oligoribonucleotides Incorporating 2'-O-Naphthyluridines2011
- Author(s)
  M. Sekine, Y. Oeda, Y. Iijima, H. Taguchi, A. Ohkubo, and K. Seio
- Journal Title
  
  Org. Biomol. Chem
  
  Volume: 9巻 Pages: 210-218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Synthesis and Hybridization Properties of 2'-0-Methylated Oligoribonucleotides Incorporating 2'-0-Naphthyluridines2011
- Author(s)
  M.Sekine, et al.
- Journal Title
  
  Org.Biomol.Chem.
  
  Volume: 76 Pages: 210-218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Synthesis and Hybridization Properties of 2'-O-Methylated Oligoribonucleotides Incorporating 2'-O-Naphthyluridines2011
- Author(s)
  M.Sekine, et al.
- Journal Title
  
  Org.Biomol.Chem.
  
  Volume: 76 Pages: 210-218
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007
[Journal Article] Stable Triplex Formation Using the Strong Stacking Effect of Consecutive Thionucleoside Moieties Incorporated into Triplex-forming Oligonucleotides2011
- Author(s)
  Ohkubo, A.; Nishino, Y.; Yokouchi, A.; Ito, Y.; Noma, Y.;Tsunoda, H.;Sekine, M
- Journal Title
  
  Chem. Commun
  
  Volume: 47 Pages: 12556-12558
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007
[Journal Article] Synthesis of 6-N-(Benzothiazol-2-yl) deoxyadenosine and Its Exciton-coupled Circular Dichroism2010
- Author(s)
  Y. Masaki, A. Ohkubo, K. Seio, and M. Sekine
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 18巻 Pages: 567-572
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Linear Relationship between Deformability and Thermal Stability of 2'-O-Modified RNA Hetero Duplexes2010
- Author(s)
  Y.Masaki, R.Miyasaka, A.Ohkubo, K.Seio, M.Sekine
- Journal Title
  
  J.Phys.Cheer.(B) 114
  
  Pages: 2517-2524
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007
[Journal Article] Linear Relationship between Deformability and Thermal Stability of 2'-O-Modified RNA Hetero Duplexes2010
- Author(s)
  Y. Masaki, R. Miyasaka, A. Ohkubo, K. Seio, and M. Sekine
- Journal Title
  
  J. Phys. Chem.(B)
  
  Volume: 114巻 Pages: 2517-2524
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Linear Relationship between Deformability and Thermal Stability of 2'-O-Modified RNA Hetero Duplexes2010
- Author(s)
  Y.Masaki, R.Miyasaka, A.Ohkubo, K.Seio, M.Sekine
- Journal Title
  
  J.Phys.Chem.(B) 114
  
  Pages: 2517-2524
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Efficient solid-phase synthesis of oligodeoxynucleotides having a 5'-terminal 2,2,7-trimethylguanosine pyrophosphate linkage2009
- Author(s)
  A.Ohkubo, K.Sasaki, Y.Noma, H.Tsunoda, K.Seio, M.Sekine
- Journal Title
  
  Bioorg.Med.Chem. 17
  
  Pages: 4819-4824
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007
[Journal Article] Introduction of 3'-Terminal Nucleosides Having a Silyl Linker into Polymer Supports without Base Protection2009
- Author(s)
  A.Ohkubo, Y.Noma, K.Aoki, H.Tsunoda, K.Seio, M Sekine
- Journal Title
  
  J.Org.Chem. 74
  
  Pages: 2817-2823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Synthesis and Properties of Nucleoside Derivatives Masked by the Chemically Stable 2-(Trimethylsilyl) benzoyl Group2009
- Author(s)
  K. Yamada, H. Taguchi, A. Ohkubo, K. Seio, and M. Sekine
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 17巻 Pages: 5928-5932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Microwave-Assisted Synthesis of 2'-O-Aryluridine Derivatives2009
- Author(s)
  Y.Oeda, Y.Iijima, H.Taguchi, A.Ohkubo, K.Seio, M.Sekine
- Journal Title
  
  Org.Lett. 11
  
  Pages: 5582-5585
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007
[Journal Article] Synthesis and hybridization of 2'-O-methyl-RNAs incorporating 2'-O-carbamoyluridine and unique participation of the carbamoyl group in U. G base pair2009
- Author(s)
  K. Seio, R. Tawarada, T. Sasami, M. Serizawa, M. Ise, A. Ohkubo, and M. Sekine
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 17巻 Pages: 7275-7280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Synthesis and hybridization of 2'-O-methyl-RNAs incorporating 2'-O-carbamoyluridine and unique participation of the carbamoyl group in U-G base pair2009
- Author(s)
  K.Seio, R.Tawarada, T.Sasami, M.Serizawa, M.Ise, A.Ohkubo, M.Sekine
- Journal Title
  
  Bioorg.Med.Chem. 17
  
  Pages: 7275-7280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] icrowave-Assisted Synthesis of 2'-O-Aryluridine Derivatives2009
- Author(s)
  Y. Oeda, Y. Iijima, H. Taguchi, A. Ohkubo, K. Seio, and M. Sekine
- Journal Title
  
  Org. Lett
  
  Volume: 11巻 Pages: 5582-5585
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Efficient solid-phase synthesis of oligodeoxynucleotides having a 5'-terminal 2, 2, 7-trimethylguanosine pyrophosphate linkage2009
- Author(s)
  A.Ohkubo, K.Sasaki, Y.Noma, H.Tsunoda, K.Seio, M.Sekine
- Journal Title
  
  Bioorg.Med.Chem. 17
  
  Pages: 4819-4824
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] 3'-Terminal Nucleosides Having a SilylLinker into Polymer Supports without Base Protection2009
- Author(s)
  A. Ohkubo, Y. Noma, K. Aoki, H. Tsunoda, K. Seio and M. Sekine
- Journal Title
  
  J. Org. Chem
  
  Volume: 74巻 Pages: 2817-2823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Synthesis and Properties of Nucleoside Derivatives Masked by the Chemically Stable 2-(Trimethylsilyl)benzoyl Group2009
- Author(s)
  K.Yamada, H.Taguchi, A.Ohkuho, K.Seio, M.Sekine
- Journal Title
  
  Bioorg.Med.Chem. 17
  
  Pages: 5928-5932
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007
[Journal Article] Microwave-Assisted Synthesis of 2'-O-Aryluridine Derivatives2009
- Author(s)
  Y.Oeda, Y.Iijima, H.Taguchi, A.Ohkubo, K.Seio, M.Sekine
- Journal Title
  
  Org.Lett. 11
  
  Pages: 5582-5585
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Synthesis and hybridization of 2'-O-methyl-RNAs incorporating 2'-O-carbamoyluridine and unique participation of the carbamoyl group in U-G base pair2009
- Author(s)
  K.Seio, R.Tawarada, T.Sasami, M.Serizawa, M.Ise, A.Ohkubo, M.Sekine
- Journal Title
  
  Bioorg.Med.Chem. 17
  
  Pages: 7275-7280
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007
[Journal Article] Synthesis of terminally modified oligonucleotides and their hybridization dependence on the size of the target RNAs2009
- Author(s)
  K.Seio, Y.Takaku, K.Miyazaki, Y.Masaki, A.Ohkubo, M.Sekine
- Journal Title
  
  Org.Biomol.Chem. 7
  
  Pages: 2440-2451
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007
[Journal Article] Synthesis of terminally modified oligonucleotides and their hybridization dependence on the size of the target RNAs2009
- Author(s)
  K.Seio, Y.Takaku, K.Miyazaki, Y.Masaki, A.Ohkubo, M.Sekine
- Journal Title
  
  Org.Biomol.Chem. 7
  
  Pages: 2440-2451
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Synthesis of terminally modifiedoligonucleotides and their hybridization dependence on the size of the target RNAs2009
- Author(s)
  K. Seio, Y. Takaku, K. Miyazaki, Y. Masaki, A. Ohkubo, and M. Sekine
- Journal Title
  
  Org. Biomol. Chem
  
  Volume: 7巻 Pages: 2440-2451
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Synthesis and Properties of Nucleoside Derivatives Masked by the Chemically Stable 2-(Trimethylsilyl) benzoyl Group2009
- Author(s)
  K.Yamada, H.Taguchi, A.Ohkubo, K.Seio, M.Sekine
- Journal Title
  
  Bioorg.Med.Chem. 17
  
  Pages: 5928-5932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Introduction of 3'-Terminal Nucleosides Having a Silyl Linker into Polymer Supports without Base Protection2009
- Author(s)
  A.Ohkubo, Y.Noma, K.Aoki, H.Tsunoda, K.Seio, M.Sekine
- Journal Title
  
  J.Org.Chem. 74
  
  Pages: 2817-2823
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007
[Journal Article] Efficient solid-phase synthesis of oligodeoxynucleotides having a 5'-terminal 2, 2, 7-trimethylguanosine pyrophosphate linkage2009
- Author(s)
  A. Ohkubo, K. Sasaki, Y. Noma, H. Tsunoda, K. Seio, and M. Sekine
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 17巻 Pages: 4819-4824
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] 核酸医薬を指向した修飾オリゴヌクレオチドの創成2015
- Author(s)
  関根光雄
- Organizer
  日本薬学会
- Place of Presentation
  神戸学院大学神戸
- Year and Date
  2015-03-29
- Invited
- Data Source
  KAKENHI-PROJECT-26560434
[Presentation] 核酸医薬を指向した修飾オリゴヌクレオチドの創成2015
- Author(s)
  関根光雄
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学
- Year and Date
  2015-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-25288074
[Presentation] 遺伝子制御機能をもつ人工核酸の合成研究2015
- Author(s)
  関根光雄
- Organizer
  日本化学会第95春季年会
- Place of Presentation
  日本大学理工学部　船橋キャンパス/薬学部
- Year and Date
  2015-03-29
- Invited
- Data Source
  KAKENHI-PROJECT-25288074
[Presentation] 遺伝子制御機能をもつ人工核酸の合成研究2015
- Author(s)
  関根光雄
- Organizer
  日本化学会
- Place of Presentation
  日本大学理工学部
- Year and Date
  2015-03-29
- Invited
- Data Source
  KAKENHI-PROJECT-26560434
[Presentation] 筋ジストロフィー治療を指向した塩基部修飾2'-0-MCE RNAの合成と性質2014
- Author(s)
  石井陽大,正木慶昭,山田剛史,岡庭夏己,永田哲也,武田伸一,金森功吏,大窪章寛,清尾康志,関根光雄
- Organizer
  第94回春季年会プログラム
- Place of Presentation
  名古屋大学東山キャンパス
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] 3-アミノピリダジン型核酸塩基を有するペプチド核酸の合成と性質2014
- Author(s)
  友利貴人,宮武佑弥,佐藤祐太,金森功吏,正木慶昭,大窪章寛,関根光雄,清尾康志
- Organizer
  第94春季年会プログラム
- Place of Presentation
  名古屋大学東山キャンパス
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] Sutudies of Modified Oligonucleotides Directed toward Nucleic Acid Drugs2014
- Author(s)
  Mitsuo Sekine
- Organizer
  Mini-Symposium on Frontiers of Nucleic Acid Therapeutics
- Place of Presentation
  Lodz, Poland
- Year and Date
  2014-09-01
- Invited
- Data Source
  KAKENHI-PROJECT-25288074
[Presentation] GFPクロモフォアを導入したDNA三重鎖の蛍光増強を目指した構造探索2014
- Author(s)
  金森功吏,高村亮宏,正木慶昭,大窪章寛,関根光雄,清尾康志
- Organizer
  第94春季年会プログラム
- Place of Presentation
  名古屋大学東山キャンパス
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] New Approach to the Synthesis of Modified Oligonucleotides. Contemporary Snapshot of Nucleic Acids Mini-symposium Dedicated to honour Professor Collin B. Reese for his contributions in the area of nucleic acids research2014
- Author(s)
  Mitsuo Sekine
- Organizer
  Contemporary Snapshot of Nucleic Acids Mini-symposium Dedicated to honour Professor Collin B. Reese for his contributions in the area of nucleic acids research
- Place of Presentation
  Polish Academy of Sciences, Poznan, Poland
- Year and Date
  2014-08-24
- Invited
- Data Source
  KAKENHI-PROJECT-25288074
[Presentation] デオキシシュードイソシチジンと5-メチル -4-ピリミジノンヌクレオシドを導入したDNA 三重鎖の塩基対形成能の評価2014
- Author(s)
  山口慧, 金森功吏,正木慶昭,大窪章寛,関根光雄,清尾康志
- Organizer
  第94回春季年会プログラム
- Place of Presentation
  名古屋大学, 東山キャンパス
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] イミダゾリノン誘導体を導入した新規蛍光核酸の合成と蛍光特性2013
- Author(s)
  金森功吏,高村亮宏,大窪章寛,関根光雄,清尾康志
- Organizer
  第93春季年会プログラム
- Place of Presentation
  立命館大学びわこ・くさつキャンパス
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] 4-(2-グアニドエチル)ピリミジン誘導体を含む三重鎖形成核酸の合成と塩基識別能2013
- Author(s)
  伊藤優,大窪章寛,山田健司,吉村貴一,金森功吏,正木慶昭,清尾康志,関根光雄
- Organizer
  第93春季年会プログラム
- Place of Presentation
  立命館大学びわこ・くさっキャンパス
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] 新規 2′-O-修飾 RNA の開発とそのエキソン・スキッピング活性2013
- Author(s)
  関根光雄
- Organizer
  第15回日本RNA学会年会
- Place of Presentation
  愛媛県・県民文化会館ひめぎんホール
- Invited
- Data Source
  KAKENHI-PROJECT-25288074
[Presentation] 塩基部修飾を導入した2'-0-[2-(N-メチルカルバモイル)エチル]修飾核酸の合成とその性質2013
- Author(s)
  石井陽大、正木慶昭、劉天文、田胡信広、岡庭夏己、山田剛史、永田哲也、武田伸一、金森功吏、大窪章寛、清尾康志、関根光雄
- Organizer
  第23回アンチセンスシンポジウム
- Place of Presentation
  徳島大学蔵本キャンパス
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] 新規 2′-O-修飾 RNA の開発とそのエキソン・スキッピング活性2013
- Author(s)
  関根光雄
- Organizer
  第15回日本RNA学会年会
- Place of Presentation
  愛媛県・県民文化会館ひめぎんホール
- Invited
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] 四塩基対認識を指向した人工三重鎖形成核酸の合成と性質2013
- Author(s)
  山田健司,大窪章寛,伊藤優,吉村貴一,金森功吏,正木慶昭,清尾康志,関根光雄
- Organizer
  第93春季年会プログラム
- Place of Presentation
  立命館大学びわこ・くさっキャンパス
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] T-A, C-G塩基対を含む配列で認識可能な新規三重鎖形成核酸の合成2013
- Author(s)
  伊藤優、大窪章寛、山田健司、吉村貴一、金森功吏、正木慶昭、清尾康志、関根光雄
- Organizer
  第23回アンチセンスシンポジウム
- Place of Presentation
  徳島大学蔵本キャンパス
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] Synthesis and properties of new triplex forming oligonucleotides capable of recognizing TA and CG base pair in parallel orientation2012
- Author(s)
  Kenji Yamada, Yu Ito, Kiichi Yoshimura, Takashi Kanamori, Akihiro Ohkubo, Kohji Seio, Mitsuo Sekine
- Organizer
  The 39th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Nagoya University(IGER)
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] チオカルボニル基を有する修飾塩基の連続導入による三重鎖形成能の向上2012
- Author(s)
  山田健司,服部勇作,印出健志,金森功吏,大窪章寛,清尾康志,関根光雄
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] Design and Synthesis of New Oligonucleotides Capable of　Forming　Triplexes Highly Selectively with DNA Duplexes　without Binding to Single Stranded mRNAs2012
- Author(s)
  関根光雄
- Organizer
  2012 International Symposium on Advanced Biological Engineering (ISABE'2012)
- Place of Presentation
  Guilin, Guangxi, China(桂林)
- Year and Date
  2012-10-25
- Invited
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] 6-チオプリンおよび4-チオピリミジン誘導体を含むオリゴヌクレオチドの合成とその三重鎖形成能2012
- Author(s)
  服部勇作・印出健志・山田健司・伊藤優・角田浩佑・大窪章寛・清尾康志・関根光雄
- Organizer
  第92春季年会
- Place of Presentation
  慶應大学
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] DNA二重鎖および三重鎖に導入したデオキシシュードイソシチジンの塩基対形成能の評価2012
- Author(s)
  金森功吏・山口慧・角田浩佑・大窪章寛・関根光雄・清尾康志
- Organizer
  第92春季年会
- Place of Presentation
  慶應大学
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] 4-O-(アミノエチル)ウリジン誘導体を含む新規三重鎖形成核酸の合成とその性質2012
- Author(s)
  伊藤優・山田健司・角田浩佑・大窪章寛・清尾康志・関根光雄
- Organizer
  第92春季年会
- Place of Presentation
  慶應大学
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] 2,2,7-トリメチルグアノシンキャップ構造およびそのアナログ構造を有するアンチセンス分子の合成と性質2011
- Author(s)
  横内瑛,山田研,鈴木真,角田浩佑,大窪章寛,清尾康志,関根光雄
- Organizer
  第5回バイオ関連化学シンポジウム
- Place of Presentation
  つくば国際会議場「エポカルつくば」
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] 4-0-(アミノエチル)ウリジン誘導体を含む新規三重鎖形成核酸の合成とその性質2011
- Author(s)
  伊藤優,西野雄大,角田浩佑,大窪章寛,清尾康志,関根光雄
- Organizer
  第92春季年会プログラム
- Place of Presentation
  慶磨大学日吉キャンパス・矢上キャンパス
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] Synthesis and Properties of Oligonucleotides 2,2,7-Trimethyl- guanosine Cap Analogues2011
- Author(s)
  Yokouchi, A.; Yamada, K.;Tsunoda, H.;Ohkubo, A.; Seio, K.;Sekine, M
- Organizer
  2011 International Graduate Forum on Biotechnology, Bioengineering and Biomedical Science
- Place of Presentation
  北京
- Year and Date
  2011-08-27
- Invited
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] 新規人工核酸の創成研究2011
- Author(s)
  関根光雄
- Organizer
  日本化学会関東支部主催群馬地区講演会
- Place of Presentation
  群馬大学
- Year and Date
  2011-07-08
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] 6-チオプリンおよび4一チオピリミジン誘導体を含むオリゴヌクレオチドの合成とその三重鎖形成能2011
- Author(s)
  服部勇作,印出健志,山田健司,伊藤優,角田浩佑,大窪章寛,清尾康志,関根光雄
- Organizer
  第92春季年会プログラム
- Place of Presentation
  慶慮大学日吉キャンパス・矢上キャンパス
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] Recent Studies on the Chemical Synthesis on Modified RNA OIigomers Directed towawd Genen Therapy2011
- Author(s)
  Sekine, M
- Organizer
  International Graduate Forum on Biotechnology, Bioengineering and Biomedical Science
- Place of Presentation
  北京
- Year and Date
  2011-08-27
- Invited
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] Synthesis and Properties of Oligonucleotides Having 5'-Termina1 2,2,7-Trimethylguanosine Cap Analogues2011
- Author(s)
  Yokouchi, A.;Yamada, K.;Tsunoda, H.; Ohkubo, A.;Seio, K.;Sekine, M
- Organizer
  The 16th Annual Meeting of the RNA Society and The RNA Society of Japan 13th Annual Meeting
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] 新規人工核酸の創成研究2011
- Author(s)
  関根光雄
- Organizer
  日本化学会関東支部主催群馬地区講演会
- Place of Presentation
  群馬大学(招待講演)
- Year and Date
  2011-07-08
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] Synthesis and Triplex Formation of RNAs Containing 8-Thioxoadenine and 2-Thiopyrimidine2011
- Author(s)
  Ohkubo, A.;Ito, Y.; Nishino, Y.;Yokouchi, A.;Tsunoda, H.; Seio, K.;Sekine, M
- Organizer
  The 16th Annual Meeting of the RNA Society and The RNA Society of Japan 13th Annual Meeting
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] Synthesis and Biological Properties of Synthesis and Biological Properties of 2'-O-Modified Oligoribonucleotide Derivatives2011
- Author(s)
  Sekine, M.
- Organizer
  XVth Symposium on Chemistry of Nucleic Acid Components SCNAC 2011
- Place of Presentation
  Cechy, Ceska republika(招待講演)
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] ホスホロアミダイト化合物を利用したオリゴヌクレオチド5'末端の新規アデニル化反応2011
- Author(s)
  田胡信広,西野雄大,角田浩佑,大窪章寛,清尾康志,関根光雄
- Organizer
  第5回バイオ関連化学シンポジウム
- Place of Presentation
  つくば国際会議場「エポカルつくば」
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] 1-アミノフタラジンを有する新規ペプチド核酸の合成2011
- Author(s)
  佐藤祐太,金森功吏,角田浩佑,大窪章寛,関根光雄,清尾康志
- Organizer
  第1回CSJ化学フェスタ2011世界化学年祈年大会
- Place of Presentation
  早稲田大学大隈記念講堂・小野梓記念館
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] 3-メチルベンゾフランを導入したウリジン誘導体の合成と二重鎖構造及び三重鎖構造中での蛍光特性2011
- Author(s)
  金森功吏,大関弘貴,徳川宗史,角田浩佑,大窪章寛,関根光雄,清尾康志
- Organizer
  第92春季年会プログラム
- Place of Presentation
  慶磨大学日吉キャンパス・矢上キャンパス
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] Synthesis and Biological Properties of Synthesis and Biological Properties of 2'-O-Modified Oligoribonucleotide Derivatives2011
- Author(s)
  Sekine, M.
- Organizer
  XVth Symposium on Chemistry of Nucleic Acid Components SCNAC 2011
- Place of Presentation
  Cechy, Ceska republika(招待講演)
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] アミノナフチリジン誘導体を含む新規三重鎖形成核酸の合成とその性質2011
- Author(s)
  山田健司,服部勇作,伊藤優,印出健志,角田浩佑,大窪章寛,清尾康志,関根光雄
- Organizer
  第92春季年会プログラム
- Place of Presentation
  慶慮大学日吉キャンパス・矢上キャンパス
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] Synthesis and Biological Properties of Synthesis and Biological Properties of 2'-O-Modified Oligoribonucleotide Derivatives2011
- Author(s)
  M. Sekine
- Organizer
  XVth Symposium on Chemistry of Nucleic Acid Components SCNAC 2011
- Place of Presentation
  Cechy, eska republika
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] マイクロフローリアクターを利用した修飾ヌクレオチドの新規合成法の開発2011
- Author(s)
  田胡信広,角田浩佑,大窪章寛,清尾康志,関根光雄
- Organizer
  第92春季年会プログラム
- Place of Presentation
  慶慮大学日吉キャンパス・矢上キャンパス
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] TMGキャップアナロクを有するモルフォリノ核酸の合成2011
- Author(s)
  山田研・横内瑛・鈴木真・角田浩佑・大窪章寛・清尾康志・関根光雄
- Organizer
  第21回アンチセンスシンポジウムおよび第11回遺伝子・デリバリー研究会シンポジウム
- Place of Presentation
  大阪大学コンベンションセンター
- Year and Date
  2011-09-01
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] An Effective Method for Phosphorodiamidate Bond Formation in the Synthesis of Morpholino Nucleic Acids2011
- Author(s)
  Harakawa, T.; Ishii, A.; Tsunoda, H.; Ohkubo, A.;Seio, K.;Sekine, M
- Organizer
  The 28th International Symposium on Nucleic Acid Chemistry(ISNAC2011)
- Place of Presentation
  Clark Memorial Student Center, Hokkaido University, Japan
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] Synthesis and Properties of Oligonucleotides 2,2,7-Trimethylguano-sine Cap Analogues2011
- Author(s)
  Ohkubo, A.; Yokouchi, A.;Yamada, K.;Tsunoda, H.; Seio, K.;Sekine, M
- Organizer
  6^<th> Cambridge Symposium on Nucleic Acids Chemistry and Biolo
- Place of Presentation
  Queens'College, Cambridge, UK
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] 新合成手法に基づく新規核酸医薬の開発2011
- Author(s)
  関根光雄
- Organizer
  千里ライフサイエンスセミナー
- Place of Presentation
  千里
- Year and Date
  2011-07-08
- Invited
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] Synthesis and Biological Properties of 2'-O-Modified Oligoribonucleotide Derivatives2011
- Author(s)
  Sekine, M
- Organizer
  XVth Symposium on Chemistry of Nucleic Acid Components SCNAC 2011
- Place of Presentation
  Cechy, Ceska republika
- Invited
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] 生体関連核酸誘導体の効率的合成法に関する研究2011
- Author(s)
  関根光雄
- Organizer
  第92春季年会プログラム
- Place of Presentation
  慶磨大学日吉キャンパス・矢上キャンパス
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] DNA二重鎖および三重鎖に導入したデオキシシュードイソシチジンの塩基対形成能の評価2011
- Author(s)
  金森功吏,山口慧,角田浩佑,大窪章寛,関根光雄,清尾康志
- Organizer
  第92春季年会プログラム
- Place of Presentation
  慶慮大学日吉キャンパス・矢上キャンパス
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] One-pot Sequential Formation of Pyro- and Triphosphate Bonds by Using O-N Phosphoryl Migration of Phosphoramidite Derivatives2011
- Author(s)
  Tago, N.;Ohkubo, A.;Tsunoda, H.;Seio, K.;Sekine, M
- Organizer
  The Seventh International Symposium on Integrated Syntheaia(ISIS-7)
- Place of Presentation
  Seaside Hotel Maiko Vill, Kobe, Japan
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] TMGキャップアナロクを有するモルフォリノ核酸の合成2011
- Author(s)
  山田研,横内瑛,鈴木真,角田浩佑,大窪章寛,清尾康志,関根光雄
- Organizer
  第21回アンチセンスシンポジウムおよび第11回遺伝子・デリバリー研究会シンポジウム
- Place of Presentation
  大阪大学コンベンションセンター
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] 新規人工核酸の創成研究2011
- Author(s)
  関根光雄
- Organizer
  日本化学会関東支部主催群馬地区講演会
- Place of Presentation
  群馬大学
- Year and Date
  2011-06-20
- Invited
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] 新規人工核酸の創成研究2011
- Author(s)
  関根光雄
- Organizer
  日本化学会関東支部主催群馬地区講演会
- Place of Presentation
  群馬大学(招待講演)
- Year and Date
  2011-07-08
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] 2-チオピリミジンおよび8-チオキソプリンを含む修飾核酸の三重鎖形成能2011
- Author(s)
  伊藤優,西野雄大,角田浩佑,大窪章寛,清尾康志,関根光雄
- Organizer
  第1回CSJ化学フェスタ2011世界化学年祈年大会
- Place of Presentation
  早稲田大学大隈記念講堂・小野梓記念館
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] Synthesis and Properties of Oligonucleotides Having 2,2,7-Trimethylguanosine Cap Analogs2011
- Author(s)
  Yamada, K.;Yokouchi, A.;Suzuki, M.; Tsunoda, H.;Ohkubo, A.;Seio, K.;Nagata, T.;Aoki, Y.;Takeda, S.;Sekine, M
- Organizer
  The 28^<th> International Symposium on Nucleic Acid Chemistry (ISNAC2011)
- Place of Presentation
  Clark Memorial Student Center, Hokkaido University, Japan
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] S-フェニルポスホロチオエート誘導体を利用した、固相上でのTMG-キャップ化反応の検討2011
- Author(s)
  山田研,鈴木真,横内瑛,角田浩佑,大窪章寛,清尾康志,関根光雄
- Organizer
  第92春季年会プログラム
- Place of Presentation
  慶磨大学日吉キャンパス・矢上キャンパス
- Year and Date
  2011-03-25
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] Oligonucleotides 2,2,7-Trimethylguano- sine Cap Analogues2011
- Author(s)
  Ohkubo, A.; Yokouchi, A.;Yamada, K.;Tsunoda, H.; Seio, K.;Sekine, M
- Organizer
  7^<th> Annual Meeting of the Oligonucleotide Therapeutics Society
- Place of Presentation
  The Royal Library, Copenhagen, Denmark
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] 2'-O-カルハモイルウリシン誘導体を有する人工核酸の合成と性質2011
- Author(s)
  徳川宗史,角田浩佑,大窪章寛,清尾康志,関根光雄
- Organizer
  第21回アンチセンスシンポジウムおよび第11回遺伝子・デリバリー研究会シンポジウム
- Place of Presentation
  大阪大学コンベンションセンター
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] New Triplex Forming Oligonucleotides Capable of Binding to DNA Duplexes under Neutral Conditions2010
- Author(s)
  M.Sekine
- Organizer
  Heidelberg University-Tokyo Institute of Technology Joint Symposium on
- Place of Presentation
  Wroclaw University, Poland
- Year and Date
  2010-07-16
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] 2'-O-MCEオリゴヌクレオチドの合成と性質2010
- Author(s)
  山田剛史、岡庭夏己、武田伸一、永田哲也、實吉尚郎、大窪章寛、関根光雄
- Organizer
  第20回アンチセンスシンポジウム
- Place of Presentation
  甲南大学
- Year and Date
  2010-12-02
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] Relationship Between Thermal Stability and Deformability of Modified RNA, XIX International Round Table on Nucleosides2010
- Author(s)
  正木慶昭・宮坂隆太・角田浩佑・大窪章寛・清尾康志・関根光雄
- Organizer
  Nucleotides and Nucleic Acids
- Place of Presentation
  クロードベルナールリヨン第一大学
- Year and Date
  2010-09-01
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] Triplex Forming Oligonucleotides Containing Thiolated Nucleobases2010
- Author(s)
  M.Sekine
- Organizer
  ICPC2010-Symposium on Biophosphates
- Place of Presentation
  Wroclaw Lniversity, Poland
- Year and Date
  2010-07-13
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] Triplex Forming ligonucleotides Containing Thiolated Nucleobases2010
- Author(s)
  M. Sekine
- Organizer
  ICPC2010-Symposium on Biophosphates
- Place of Presentation
  Wroclaw University, Poland
- Year and Date
  2010-07-16
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] Synergetic effects of 2-thiolation and 5-propynylation of the uracil base on the stability of RNA duplexes2010
- Author(s)
  R. Miyasaka, Y. Masaki, H. Tsunoda, A. Ohkubo, K. Seio, and M. Sekine
- Organizer
  第37回国際核酸化学シンポジウム
- Place of Presentation
  よこはま・はまぎんホール
- Year and Date
  2010-11-10
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] Triplex Forming Oligonucleotides Containing Thiolated Nucleobases2010
- Author(s)
  M.Sekine
- Organizer
  ICPC2010-Symposium on Biophosphates
- Place of Presentation
  Wroclaw University, Poland
- Year and Date
  2010-07-13
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] New Triplex Forming Oligonucleotides Capable of Binding to DNA Duplexes under Neutral Conditions2010
- Author(s)
  M. Sekine
- Organizer
  Heidelberg University-Tokyo Institute of Technology Joint Symposium on
- Place of Presentation
  Wroclaw University, Poland
- Year and Date
  2010-07-16
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] 新規核酸医薬の創成を指向した合成研究2010
- Author(s)
  関根光雄
- Organizer
  第54回日本薬学会関東支部大会
- Place of Presentation
  東京薬科大学
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] Synthesis and Properties of Modified Oligonucleotides Capable Triplex Formation with DNA Duplexes under Neutral Conditions2010
- Author(s)
  M.Sekine
- Organizer
  2010環太平洋国際化学会議
- Place of Presentation
  Hawaii, Convention Center, USA
- Year and Date
  2010-12-15
- Data Source
  KAKENHI-PLANNED-21106007
[Presentation] Synthesis and Properties of 2'-O-[ 2-(N-methyl) carbamoyl] ethyl-RNAs2010
- Author(s)
  T. Yamada, N. Okaniwa, H. Saneyoshi, A. Ohkubo, K. Seio, T. Nagata, S. Takeda, and M. Sekine
- Organizer
  第37回国際核酸化学シンポジウム
- Place of Presentation
  よこはま・はまぎんホール
- Year and Date
  2010-11-10
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] Synthesis and Properties of Modified Oligonucleotides Capable Triplex Formation with DNA Duplexes under Neutral Conditions2010
- Author(s)
  M. Sekine
- Organizer
  2010環太平洋国際化学会議
- Place of Presentation
  Hawaii, Convention Center, USA
- Year and Date
  2010-12-15
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] 新規核酸医薬の創成を指向した合成研究2010
- Author(s)
  関根光雄
- Organizer
  第54回日本薬学会関東支部大会
- Place of Presentation
  東京薬科大学
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] Design and synthesis of fluorescent nucleosides for the development of oligonucleotides capable of emitting fluorescence upon formation of nucleic acid structures
- Author(s)
  Mitsuo Sekine
- Organizer
  FB3 Fluorescent Biomolecules and Their Building Blocks-Design and Applications
- Place of Presentation
  UC San Diego, USA
- Year and Date
  2014-08-06 – 2014-08-09
- Invited
- Data Source
  KAKENHI-PROJECT-25288074
[Presentation] Synthesis and Properties of Base or Sugar Modified RNA Derivatives
- Author(s)
  Mitsuo Sekine
- Organizer
  XVIth Symposium on Chemistry of Nucleic Acid Components SCNAC 2014
- Place of Presentation
  Cesky Krumlov, Czech Republic
- Year and Date
  2014-06-08 – 2014-06-12
- Invited
- Data Source
  KAKENHI-PROJECT-25288074
[Presentation] Studies on modified oligonucleotides capable of precise recognition and strong binding affinity for target nucleic acids
- Author(s)
  Mitsuo Sekine
- Organizer
  The 41th International Symposium on Nucleic Acid Chemistry
- Place of Presentation
  Kitakyushu International Conference Center
- Year and Date
  2014-11-05 – 2014-11-07
- Invited
- Data Source
  KAKENHI-PROJECT-25288074

1. HATA Tsujiaki (00016049)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. 金子主税 (40013833)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. 松田彰 (90157313)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. 大塚栄子 (80028836)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. HAYAKAWA Yoshihiro (50022702)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. WADA Takeshi (90240548)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
7. 佐々木琢磨 (90109976)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. ISHIKAWA Masahide (50212858)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 小林進 (70101102)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 向山光昭 (60016003)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. OHKUBO Akihiro (60376960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 31 results
12. NISHINA Kikuko (40198479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KAGAWA Toshiharu (50108221)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NAKAHAMA Seiich (90016410)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KUMURA Tsutomu (40016506)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MAKINO Keisuke (50159141)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. SEIO Khoji (20313356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 西村善文 (70107390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 綿矢有佑 (90127598)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 渋谷雅之 (40027066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 高久洋 (50101267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 石戸良治 (60016037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 上田亨 (00001032)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 谷口すみ子 (30217129)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. KANEKO Mineo (00185935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 西川一八 (60109262)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. KIDA Masahide

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. KIMOTO Haruo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 高橋秀臣

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SEKINE MITSUO 関根 光雄

SEKINE Mitsuo 関根 光雄

関根 光男 セキネ ミツオ

Research Projects

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Co-Researchers

Development of the ultimate third nucleobase required for expansion of the genetic codePrincipal Investigator

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筋ジストロフィー治療薬を目指した新規人工核酸の合成Principal Investigator

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Sequential synthesis of functional synthetic nucleic acidsPrincipal Investigator

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Exploration of Innovative Methods for the synthesis of RNA Capable of Machting Requirement for New dayPrincipal Investigator

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二重分子識別原理に基づく新しい高精度DNA/RNA検出法Principal Investigator

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二重分子識別原理に基づく新しい高精度DNA/RNA検出法Principal Investigator

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非天然型DNA2重らせんの創成Principal Investigator

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ベント構造を利用する新しい高精度DNA/RNA検出法Principal Investigator

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抗C型肝炎ウイルス活性をもつ新しいヌクレオシド誘導体の合成と活性評価Principal Investigator

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EXPLORATION OF ULTIMATE NEW SYNTHETIC METHOD OF DNA/RNA BY USE OF "PROTON-BLOCK APPROACH"-DIRECTED TOWARD ESTABLISHMENT OF INOVATIVE METHOD FOR THE SYNTHESIS OF NUCLEIC ACIDS WITHOUT BASE PROTECTION-Principal Investigator

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ドラッグデザインによる新しい抗がん剤の合成

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5’水酸基と3’リン酸基の同時保護法による核酸の化学合成Principal Investigator

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Basic Research for the Creation of Artificial Nucleic Acids and Related Biomolecules with Useful Functions

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SEKINE MITSUO 関根光雄

SEKINE Mitsuo 関根光雄

関根光男セキネミツオ