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SEKINE MITSUO  関根 光雄

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SEKINE Mitsuo  関根 光雄

関根 光男  セキネ ミツオ

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Researcher Number 40111679
Other IDs
Affiliation (based on the past Project Information) *help 2012 – 2014: 東京工業大学, 生命理工学研究科, 教授
2009 – 2011: Tokyo Institute of Technology, 大学院・生命理工学研究科, 教授
2001 – 2004: Tokyo Institute of Technology, Department of Life Science, Dr. Sc., 大学院・生命理工学研究科, 教授
2000: 東京工業大学, 大学院・生命理工学研究所, 教授
1999: 東京工業大学, 大学院・生命理工学研究科, 教授 … More
1999: 東工大, 生命理工学部, 助教授
1990 – 1998: 東京工業大学, 生命理工学部, 助教授
1990: 東工大, 生命理工学部, 助教授
1989: 東京工業大学, 理学部生命理学科, 助教授
1988: 東京工業大学, 大学院・総合理工, 講師
1988: 東京工業大学, 大学院総合理工学研究科, 講師
1987: 東京工業大学, 大学院・総合理工学研究所, 助手
1987: The Graduate School at Nagatsuta. T.I.T. Associate, 大学院総合理工学研究所, 助手
1986: 東京工業大学, 総合理工学研究科, 助手 Less
Review Section/Research Field
Principal Investigator
天然物有機化学 / Bioorganic chemistry / Biological Sciences / Living organism molecular science / Science and Engineering / Bio-related chemistry / Biomolecular chemistry / Molecular biology / 広領域
Except Principal Investigator
Chemical pharmacy / 科学教育(含教育工学) / Chemistry / 天然物有機化学
Keywords
Principal Investigator
RNA / tRNA / コンホメーション / 固相合成 / SOLID PHASE SYNTHESIS / アンチコドン / 水素結合 / ベント構造 / 遺伝子治療 / 3'-endo … More / シクロウリジル酸 / フェロセン / 固相合成法 / 筋ジストロフィー / HIV / ANTISENCE NUCLEIC ACID / 保護基 / なげなわ構造 / リン酸化 / Uターン構造 / コドン / ペプチド核酸 / PNA / 分子力場計算 / アンチセンス / 立体異性体 / リン酸トリエステル / マイナーグルーブバインダー / 2'-O-MCE-RNA / 核酸医薬 / アンチジーン法 / 人工核酸 / 塩基対形成能 / アミダイトユニット / RNAの化学合成 / 酵素耐性 / アンチセンス核酸 / 2'-PHOSPHATE / ENZYME RESISTANCE / AMIDITE / アンチセンスDNA / メチル化 / カルバモイルホスホネ-ト / 機能性DNA / スプライシング / イントロン / 分岐構造 / 脱保護 / NMR / 核酸の化学合成 / スペーサー / U-ターン構造 / ベントRNA / がん / ハイブリダイゼーション / 環状ウリジル酸 / rRNA / ab initio計算 / 塩基対水素結合 / 2-チオウラシル塩基 / 二重分子識別原理 / DNA検出法 / 電気化学的遺伝子検出法 / ハイブリダイセーション / 人工RNA / BVDV / 3'-Ο-BDTチミジ / 増殖阻害 / ブレディニン / HCVの代替ウィルス / 抗C型肝炎ウイルス剤 / 4-N-メトキシカルボニルシチジン / マイナーグルーブ / ピロール / イミダゾール / ホリアミド分子 / 塩基配列認識 / 2重分子認識 / 電気化学応答 / ミスマッチ / N-アシル型DNA / 非W-C型DNA2重らせん / シランジイル型のスペーサー / DNAプローブ / 遺伝診断 / 塩基対 / mRNA検出法 / 固相担体 / Dervan則 / 電気化学的酸化還元反応 / DNA2重らせん / ポリアミド / 遺伝子診断法 / 二重分子識別 / 連続合成 / マイクロフロー / U1snRNA / muscular dystrophy / trimethylguanosine cap / RNA transcript / 集積合成 / TMGキャップ構造 / 連続的固相合成 / 三重鎖形成核酸 / マイクロフロー系反応 / エキソン・スキッピング / 筋ジストロフィー医薬 / ホスホロチオエート / 3重鎖形成核酸 / 修飾RNA合成 / マイクロフロー合成 / 相間移動触媒反応 / 塩基識別能 / Activator 42 / 分子動力学的解析 / 塩素対形成能 / 分子設計 / 2重鎖熱融解曲線 / 修飾塩基 / 生体高分子 / RNA合成 / 2'水酸基の保護基 / RNA医薬 / Michael反応 / シアノエチル基 / MCE基 / 2'水酸某の保護基 / 塩基部無保護 / マイケル反応 / 2'-保護基 / シアノエチル化 / 脱アミノ化反応 / 合成モノマーユニット / アデノシン / グアノシン / 2'-O-修飾RNA / エキソンスキッピング / 2-チオウラシル / 2ーチオチミン / ホスホロチオエートRNA / 2,6-ジアミノプリン / (ピロール-2-イル)カルボニル基 / 新規塩基対 / DNAポリメラーゼ / 人工塩基 / トリリン酸化 / 遺伝暗号拡張 / 光延反応 / ヌクレオチドプロテイン / ポリオウィルス / ペプチド / 環状RNA / オリゴヌクレオチド合成 / アンチ核酸 / 2'-リン酸 / 化学合成 / 固相法 / アミダイト / 酸素耐性 / 2'-リン酸化RNA / アミダイト試薬 / エイズ / 環状シリルエーテル / 2'、3'-リン酸基転移 / チオリン酸基 / CHEMICALSYNTHESIS / 化学発光 / ビオチン / 標識 / 塩基配列決定法 / ジホスフェート / リンカー / CHEMICAL SYNTHESIS / 分子内環状化反応 / 二重らせん形成 / 3′-endo / シクロヌクレオチド / 分子内水素結合 / H-ホスホネートDNA / CONFORMATION / 3'-ENDO / CYCLOURIDYLIC ACID / INTRAMOLECULAR CYCLIZATION / MOLECULAR MECHANICS / DUPLEX FORMATION / 修飾RNA / 合成RNA / 光クロスリンク / 2-アジドデオイシアデノシン / U1RNA / 4-チオウリジン / 6-チオイノシン / 6-チオグアノシン / アミダイト法 / ホスホネート法 / 縮合反応 / ANTISENCE NUCLEIC ACID RNA / MODIFIED RNA / SYNTHETIC / TRANSFER RNA SYNTHESIS / PHOTOCROSSLINKING / SOLID PHASE / 2-AZIDODEOXYADENOSINE / U1 RNA / 塩基部無保護DNAの化学合成 / 活性ホスファイト法 / 修飾DDNA / 遺伝子診断 / DNAチップ / プロトンブロック法 / 塩基部位無保護DNA合成法 / プロントンブロック法 / ホスファチル化 / DNAの化学合成 / キャップ化反応 / ン-メチルピロリドン / 溶媒効果 / DNA CHEMICAL SYNTHESIS / NUCLEOBASE / ACTIVATOR / PROTECTING GROUP / LINKER / PHOSPHORAMIDITE METHOD / OLIGODEOXYNUCLEOTIDE … More
Except Principal Investigator
核酸 / 構造 / アンチセンス核酸 / オリゴヌクレオチド / 炭素環ヌクレオシド / 抗HIV活性 / グリコシル化反応 / 分岐RNA / DNA / RNA / 機能 / 有機化学 / 分子設計 / 遺伝子 / RNAの化学合成 / ヌクレオシド / CMP-Neu5Ac / リボザイム / レトロアルド-ル反応 / ブレオマイシン / ディスタマイシン / 抗腫瘍性 / アデノシンデアミナーゼ / 核酸塩基 / β-ヌクレオシド / C-myb protooncogene / 投げ縄構造 / CNDAC / ルイス酸 / 塩基特異性 / 2'-リン酸化RNA / 転移反応 / フローサイトメトリー / 核酸構造 / 核酸有機化学 / NMR / 機能性核酸 / 核酸高次構造 / 核酸合成 / 核酸水素給合 / 代謝拮抗剤 / 抗がん剤 / アポトーシス / カスパーゼ / p53 / RNA合成阻害剤 / ドラッグデザイン / 血管新生 / エンジイン / 核酸の化学合成 / 理工系大学テキストデータベース / 語彙調査 / 漢字頻度 / 助詞相当句 / 構文解析 / ディスコース分析 / 科学技術日本語講義 / 科学技術文章読解教科書 / ディスコーテ分析 / 理工系大学テキスト / 形態素解析 / 専門日本語講義 / デ-タベ-ス入力 / 頻度解析プログラム / ニ-ズアナリシス / 学習行動分析 / CAI / Text data base of science and technology / Vocabulary survey / Frequency of c hinese characters / Particles equivalents / Syntactic analysis / Discourse analysis / Lecturs on science and technology in Japanese / Scientific and technological text books for reading comprehenshion / ホスホロアミダイト法 / アリル保護法 / 酸 / アゾール複合体 / オキザノシン / テロメア / H-ホスホネート法 / N-アシル化DNA / ヌクレオチド化学合成 / CMP-New5Ac / デオキシオキザノシン / 2-5A / 一酸化窒素 / RNAオリゴマー / 遺伝子傷害 / クロスリンク / N-アシルDNA / 塩基対形成能 / 分子認識能 / 塩基部無保護アミダイト法 / 修飾DNAオリゴマー / アリル保護アミダイト法 / DNA-ペプチドコンジュゲート / 一酸化窒素による発ガン / 塩基配列認識ペプチド / phosphoramidite method / allyl protection / acid / azole complex / oxanosine / telomere / H-phosphonate method / N-acylated DNA / 投げなわ構造 / リン酸トリエステル法 / リン酸化 / Lariat Structure / Branched RNA / Phosphotriester Approach / Phosphorylation Less
  • Research Projects

    (37 results)
  • Research Products

    (128 results)
  • Co-Researchers

    (30 People)
  •  Development of the ultimate third nucleobase required for expansion of the genetic codePrincipal Investigator

    • Principal Investigator
      SEKINE Mitsuo
    • Project Period (FY)
      2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Biomolecular chemistry
    • Research Institution
      Tokyo Institute of Technology
  •  筋ジストロフィー治療薬を目指した新規人工核酸の合成Principal Investigator

    • Principal Investigator
      関根 光雄
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bio-related chemistry
    • Research Institution
      Tokyo Institute of Technology
  •  Sequential synthesis of functional synthetic nucleic acidsPrincipal Investigator

    • Principal Investigator
      SEKINE MITSUO
    • Project Period (FY)
      2009 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Science and Engineering
    • Research Institution
      Tokyo Institute of Technology
  •  Exploration of Innovative Methods for the synthesis of RNA Capable of Machting Requirement for New dayPrincipal Investigator

    • Principal Investigator
      SEKINE Mitsuo
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Living organism molecular science
    • Research Institution
      Tokyo Institute of Technology
  •  二重分子識別原理に基づく新しい高精度DNA/RNA検出法Principal Investigator

    • Principal Investigator
      関根 光雄
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Institute of Technology
  •  二重分子識別原理に基づく新しい高精度DNA/RNA検出法Principal Investigator

    • Principal Investigator
      関根 光雄
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Institute of Technology
  •  非天然型DNA2重らせんの創成Principal Investigator

    • Principal Investigator
      関根 光雄
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Living organism molecular science
    • Research Institution
      Tokyo Institute of Technology
  •  ベント構造を利用する新しい高精度DNA/RNA検出法Principal Investigator

    • Principal Investigator
      関根 光雄
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Institute of Technology
  •  抗C型肝炎ウイルス活性をもつ新しいヌクレオシド誘導体の合成と活性評価Principal Investigator

    • Principal Investigator
      関根 光雄
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Institute of Technology
  •  EXPLORATION OF ULTIMATE NEW SYNTHETIC METHOD OF DNA/RNA BY USE OF "PROTON-BLOCK APPROACH"-DIRECTED TOWARD ESTABLISHMENT OF INOVATIVE METHOD FOR THE SYNTHESIS OF NUCLEIC ACIDS WITHOUT BASE PROTECTION-Principal Investigator

    • Principal Investigator
      SEKINE Mitsuo
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Bioorganic chemistry
    • Research Institution
      TOKYO INSTITUTE OF TECHNOLOGY
  •  ドラッグデザインによる新しい抗がん剤の合成

    • Principal Investigator
      松田 彰
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Hokkaido University
  •  5’水酸基と3’リン酸基の同時保護法による核酸の化学合成Principal Investigator

    • Principal Investigator
      関根 光雄
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Bioorganic chemistry
    • Research Institution
      Tokyo Institute of Technology
  •  Basic Research for the Creation of Artificial Nucleic Acids and Related Biomolecules with Useful Functions

    • Principal Investigator
      HAYAKAWA Yoshihiro
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Review Section
      Chemistry
    • Research Institution
      Nagoya University
  •  tRNAに存在する特異な構造モチーフの分子固定と構造解析Principal Investigator

    • Principal Investigator
      関根 光雄
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  ベント構造をもつ核酸の化学合成Principal Investigator

    • Principal Investigator
      関根 光雄
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Bioorganic chemistry
    • Research Institution
      Tokyo Institute of Technology
  •  tRNAアンチコドン部位のコンホメーションの人工固定化およびその分子認識能Principal Investigator

    • Principal Investigator
      関根 光雄
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  がん遺伝子に特異的に結合できるペプチド核酸を用いる新しいがん治療法Principal Investigator

    • Principal Investigator
      関根 光雄
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  MOLECULAR DESIGN OF NEW EFFECTIVE ANTISENSE NUCLEIC ACIDS CAPABLE OF HYBRIDIZATION TO THE TARGET NENESPrincipal Investigator

    • Principal Investigator
      SEKINE Mitsuo
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Bioorganic chemistry
    • Research Institution
      TOKYO INSTITUTE OF TECHNOLOGY
  •  DEVELOPMENTS OF THE METHOD FOR THE CHEMICAL SYNTHESIS OF RNA CONTAINING MODIFIED BASED" -DIRECTED TOWARD FULL AUTOMATION OF RNA CONTAINING MODIFIED BASES BY USE OF NEW SYNTHETIC UNITS-Principal Investigator

    • Principal Investigator
      SEKINE Mitsuo
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      広領域
    • Research Institution
      TOKYO INSTITUTE OF TECHNOLOGY
  •  tRNAアンチコドン部位のコンホメーションの人工的固定化およびその分子認識能Principal Investigator

    • Principal Investigator
      関根 光雄
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  がん遺伝子に特異的に結合できるペプチド核酸を用いる新しいがん治療法-高ハイブリダイゼーション能力をもつ新素材分子の可能性-Principal Investigator

    • Principal Investigator
      関根 光雄
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  特異な構造をもつヌクレオシドの化学合成と反応

    • Principal Investigator
      金子 主税
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University
  •  tRNAアンチコドン部位のコンホメーションの人工的固定化およびその分子認識能Principal Investigator

    • Principal Investigator
      関根 光雄
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  CHEMICAL SYNTHESIS OF A NEW MATERIAL OF ANTISENSE NUCLEIC ACID "2'-PHOSPHORYLATED RNAS" -DIRECTED TOWARD ITS BASIC STRUCTURAL STUDIES AND REGULATION OF EXPRESSION OF HIV VIRUS-Principal Investigator

    • Principal Investigator
      SEKINE Mitsuo
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Molecular biology
    • Research Institution
      TOKYO INSTITUTE OF TECHNOLOGY
  •  核酸の構造と機能の有機化学的展開(成果とりまとめ)

    • Principal Investigator
      畑 辻明
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  アンチセンス核酸の活性と水素結合の機能の研究

    • Principal Investigator
      大塚 栄子
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Hokkaido University
  •  CHEMICAL SYNTHESIS OF A NEW MATERIAL OF ANTISENSE NUCLEIC ACID"2"PHOSTHORYLATEDRNAS" DIRETED TOWARD IIS BASIC STRUCTRAL STUDIES AND REGULATION OF EXPRESSION OF HIV VIRUS-Principal Investigator

    • Principal Investigator
      SEKINE Mitsuo
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      天然物有機化学
    • Research Institution
      TOKYO INSTITUTE OF TECHNOLOGY
  •  特異な構造をもつヌクレオシドの化学合成と反応

    • Principal Investigator
      金子 主税
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University
  •  核酸の構造と機能の有機化学的展開

    • Principal Investigator
      畑 辻明
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  特異な分岐構造をもつ核酸の化学合成と機能Principal Investigator

    • Principal Investigator
      関根 光雄
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  核酸の構造と機能の有機化学的展開

    • Principal Investigator
      HATA Tsujiaki
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Institution
      Tokyo Institute of Technology
  •  Development of Japanese textbooks for Science and Technology

    • Principal Investigator
      NISHINA Kikuko
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      科学教育(含教育工学)
    • Research Institution
      Education Center for Foreign Student;Tokyo Institute of Technology
  •  標的遺伝子の選択的不活性化機能をもつアンチセンスDNAの設計と合成Principal Investigator

    • Principal Investigator
      関根 光雄
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      天然物有機化学
    • Research Institution
      Tokyo Institute of Technology
  •  核酸および核酸構成成分の合成と生体機能に関する研究

    • Principal Investigator
      畑 辻明
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Tokyo Institute of Technology
  •  投げなわ構造をもつRNA分子の2'-5'結合を含む環状RNAの構築反応Principal Investigator

    • Principal Investigator
      関根 光雄
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      天然物有機化学
    • Research Institution
      Tokyo Institute of Technology
  •  ペプチド側鎖に共有結合したRNAオリゴマーの化学合成に関する基礎的研究Principal Investigator

    • Principal Investigator
      関根 光雄
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      天然物有機化学
    • Research Institution
      Tokyo Institute of Technology
  •  Chemical Synthesis of RNAs Containing Lariat Structure

    • Principal Investigator
      HATA Tsujiaki
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      天然物有機化学
    • Research Institution
      Tokyo Institute of Technology

All 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book

  • [Book] Synthesis and Exon-Skipping Assay of Chemically Modified RNAs, in RNA Technologies: DNA and RNA Chemical Biology in Science and Medicine, ed. V. A. Erdmann, W. T. Markiewicz, and J. Barciszewski. Chaptor 192014

    • Author(s)
      Y. Masaki, T. Yamada, H. Saneyoshi, A. Ohkubo, K. Seio, and M. Sekine
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Journal Article] A new modified cytosine base capable of base pairing with guanine using four hydrogen bonds2014

    • Author(s)
      Yamada, K.; Masaki, Y.; Tsunoda, H.; Ohkubo, A.; Seio, K.;Sekine, M
    • Journal Title

      Org. Biomol. Chem

      Volume: 12 Pages: 2255-2262

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Journal Article] Properties of 5- and/or 2-modified 2 '-O-cyanoethyl uridine residue: 2 '-O-cyanoethyl-5-propynyl-2-thiouridine as an efficient duplex stabilizing component2014

    • Author(s)
      Masaki Y, Miyasaka R, Hirai K, Kanamori T, Tsunoda H, Ohkubo A, Seio K, Sekine M
    • Journal Title

      ORGANIC & BIOMOLECULAR CHEMISTRY

      Volume: 12 Pages: 1157-1162

    • DOI

      10.1039/c3ob41983e

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24550184, KAKENHI-PROJECT-25288074
  • [Journal Article] Development of New Methods for Synthesis of Artificial Nucleic Acids having Various Functional Groups2014

    • Author(s)
      Ohkubo, Akihiro; Seio, Kohji; Sekine, Mitsuo
    • Journal Title

      JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN

      Volume: 72 Pages: 899-909

    • NAID

      130004691490

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25288074
  • [Journal Article] A new modified cytosine base capable of base pairing with guanine using four hydrogen bonds2014

    • Author(s)
      Yamada K, Masaki Y, Tsunoda H, Ohkubo A, Seio K, Sekine M.
    • Journal Title

      Org Biomol Chem.

      Volume: 12 Pages: 2255-2262

    • DOI

      10.1039/c3ob42420k

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007, KAKENHI-PROJECT-24550184
  • [Journal Article] Synthesis and properties of oligonucleotides modified with 2 '-O-(2-carboxyethyl)nucleotides and their carbamoyl derivatives2014

    • Author(s)
      Yamada T, Masaki Y, Okaniwa N, Kanamori T, Ohkubo A, Tsunoda H, Seio K, Sekine M
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 12 Pages: 6457-6464

    • DOI

      10.1039/c4ob01260g

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24550184, KAKENHI-PROJECT-25288074, KAKENHI-PROJECT-26810086
  • [Journal Article] Properties of 5-and/or 2-modified 2'-O-cyanoethyl uridine residue: 2'-O-cyanoethyl-5-propynyl-2-thiouri dine as an efficient duplex stabilizing component2014

    • Author(s)
      Masaki, Y.; Miyasaka, R.;Hirai, K.;Kanamori, T.; Tsunoda, H.; Ohkubo, A.; Seio, K.; Sekine, M
    • Journal Title

      Org. Biomol. Chem

      Volume: 12 Pages: 1157-1162

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Journal Article] Base recognition of gap sites in DNA-DNA and DNA-RNA duplexes by short oligonucleotides2013

    • Author(s)
      Yamada, K.;Ohkubo, A.; Esaka, Y.; Kanamori, T.;Masaki, Y.;Seio, K.;Sekine, M. Bioorg
    • Journal Title

      Med. Chem. Lett

      Volume: 23 Pages: 3448-3451

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Journal Article] Remarkable stabilization of antiparallel DNA triplexes by strong stacking effects of consecutively modified nucleobases containing thiocarbonyl groups2013

    • Author(s)
      Yamada K, Hattori Y, Inde T, Kanamori T, Ohkubo A, Seio K, Sekine M.
    • Journal Title

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

      Volume: 23 Pages: 776-778

    • DOI

      10.1016/j.bmcl.2012.11.079

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007, KAKENHI-PROJECT-24550184, KAKENHI-PROJECT-25288074
  • [Journal Article] Chemical synthesis of U1 snRNA derivatives.2013

    • Author(s)
      Ohkubo, A.; Kondo, Y.; Suzuki, M.;Kobayashi, H.;Kanamori, T.; Masaki, Y.; Seio, K.; Nagai, K.; Sekine, M
    • Journal Title

      Org. Lett.

      Volume: 15 Pages: 4386-4389

    • DOI

      10.1021/ol401917r

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007, KAKENHI-PROJECT-24550184, KAKENHI-PROJECT-25288074
  • [Journal Article] 61. Base recognition of gap sites in DNA-DNA and DNA-RNA duplexes by short oligonucleotides2013

    • Author(s)
      Yamada K, Ohkubo A, Esaka Y, Kanamori T, Masaki Y, Seio K, Sekine M.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 23 Pages: 3448-3451

    • DOI

      10.1016/j.bmcl.2013.03.054

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007, KAKENHI-PROJECT-24550184, KAKENHI-PROJECT-25288074
  • [Journal Article] Remarkable stabilization of antiparallel DNA triplexes by strong stacking effects of consecutively modified nucleobases containing thiocarbonyl groups2013

    • Author(s)
      Yamada, K.; Hattori, Y.; Inde, T.; Kanamori, T.; Ohkubo, A.; Seio, K.; Sekine, M. Bioorg
    • Journal Title

      Med. Chem. Lett

      Volume: 23 Pages: 776-778

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Journal Article] Fluorescent properties of oligonucleotides doubly modified with an indole-fused cytosine analog and 2-aminopurine2013

    • Author(s)
      Seio, K.; Kanamori, T.;Tokugawa, M.;Ohzeki, H.;Masaki, Y.; Tsunoda, H.; Ohkubo, A.; Sekine, M. Bioorg
    • Journal Title

      Med. Chem

      Volume: 21 Pages: 3197-3201

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Journal Article] Modified oligodeoxynucleotide primers for reverse-transcription of target RNAs that can discriminate among length variants at the 3'-terminus2013

    • Author(s)
      Iijima, Y.;Kojima, S.; Kodama, E.; Kurohagi, S.; Kanamori, T.; Masaki, Y.; Ohkubo, A.; Sekine, M.;Seio, K
    • Journal Title

      Org. Biomol. Chem

      Volume: 11 Pages: 8276-8282

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Journal Article] Prediction of the stability of modified RNA duplexes based on deformability analysis: oligoribonucleotide derivatives modified with 2'-O-cyanoethyl-5-propynyl-2-thiouridine as a promising component.2012

    • Author(s)
      Masaki, Y.; Miyasaka, R.;Hirai, K.;Tsunoda, H.; Ohkubo, A.;Seio, K.;Sekine, M
    • Journal Title

      CHEMICAL COMMUNICATIONS

      Volume: 48 Pages: 7313-7315

    • DOI

      10.1039/c2cc33409g

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007, KAKENHI-PROJECT-24550184
  • [Journal Article] Synthesis of 5'-terminal capped oligonucleotide using O-N phosphoryl migration of phosphoramidite derivatives.2012

    • Author(s)
      Ohkubo, A.;Tago, N.;Nishino, Y.;Yamada, K.; Tsunoda, H.:Seio, K.:Sekine, M
    • Journal Title

      Org. Lett.

      Volume: 14 Pages: 10-13

    • DOI

      10.1021/ol2026075

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007, KAKENHI-PROJECT-24550184
  • [Journal Article] Development of an Efficient Method for Phosphorodiamidate Bond Formation by Using Inorganic Salts2012

    • Author(s)
      Harakawa, T.; Tsunoda, H.; Ohkubo, A.;Seio, K.;Sekine, M. Bioorg
    • Journal Title

      Med. Chem. Lett

      Volume: 22 Pages: 1445-1447

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Journal Article] DNA Duplexes and Triplex-Forming Oligodeoxynucleotides Incorporating Modified Nucleosides Forming Stable and Selective Triplexes2012

    • Author(s)
      T. Kanamori, Y. Masaki, M. Mizuta, H. Tsunoda, A. Ohkubo, M. Sekine, and K. Seio
    • Journal Title

      Org. Biomol. Chem

      Volume: 10巻 Pages: 1007-1013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Journal Article] Synthesis and Properties of Cationic 2'-O-[ N-(4-aminobutyl) carbamoyl] modified Oligonucleotides.2012

    • Author(s)
      K. Seio, M. Tokugawa, T. Kanamori, H. Tsunoda, A. Ohkubo, and M. Sekine
    • Journal Title

      Bioorg. Med. Chem. Lett

      Volume: 22巻 Pages: 2470-2473

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Journal Article] DNA Duplexes and Triplex-Forming Oligodeoxynucleotides Incorporating Modified Nucleosides Forming Stable and Selective Triplexes2012

    • Author(s)
      Kanamori, T.; Masaki, Y.; Mizuta, M.; Tsunoda, H.; Ohkubo, A.; Sekine, M.; Seio, K.
    • Journal Title

      Org.Biomol.Chem

      Volume: 10 Pages: 1007-1013

    • DOI

      10.1039/c1ob06411h

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007, KAKENHI-PROJECT-21241053
  • [Journal Article] Synthesis of 5'-Terminal Capped Oligonucleotides Using O-N Phosphoryl Migration of Phosphoramidite Derivatives2012

    • Author(s)
      Ohkubo, A.; Nishino, Y.; Ito, Y.; Tsunoda, H.; Seio, K.; Sekine
    • Journal Title

      Org. Biomol. Chem.

      Volume: 10 Pages: 10-13

    • DOI

      10.1039/c2ob06641f

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007, KAKENHI-PROJECT-21241053, KAKENHI-PROJECT-22750146, KAKENHI-PROJECT-24550184
  • [Journal Article] Formation of New Base Pairs between Inosine and 5-Methyl-2-thiocytidine Derivatives2012

    • Author(s)
      A. Ohkubo, Y. Nishino, Y. Ito, H. Tsunoda, K. Seio, and M. Sekine
    • Journal Title

      Org. Biomol. Chem

      Volume: 10巻 Pages: 10-13

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Journal Article] Formation of New Base Pairs between Inosine and 5-Methyl-2-thiocytidine Derivatives2012

    • Author(s)
      Ohkubo, A.;Nishino, Y.; Ito, Y.;Tsunoda, H.;Seio, K.;Sekine, M
    • Journal Title

      Org. Biomol. Chem

      Volume: 10 Pages: 2008-2010

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Journal Article] Synthesi and Properties of Cationic 2'-O-[N-(4-aminobutyl)carbamoyl]modified Oligonucleotides2012

    • Author(s)
      Seio, K.; Tokugawa, M.; Kanamori, T.; Tsunoda, H.; Ohkubo, A.; Sekine, M
    • Journal Title

      Bioorg.Med.Chem.Lett

      Volume: 22 Pages: 2470-2473

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Journal Article] Synthesis and Properties of Cationic 2'O-[N-(4-aminobutyl)carbamoyl]- modified Oligonucleotides2012

    • Author(s)
      Seio, K.; Tokugawa, M.; Kanamori, T.; Tsunoda, H.;Ohkubo, A.;Sekine, M. Bioorg
    • Journal Title

      Med. Chem. Lett

      Volume: 22 Pages: 2470-2473

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Journal Article] Synthesis and Properties of Cationic 2'-O-[N-(4-aminobutyl)carbamoyl]modified Oligonucleotides2012

    • Author(s)
      Seio, K.; Tokugawa, M.; Kanamori, T.; Tsunoda, H.; Ohkubo, A.; Sekine, M
    • Journal Title

      Bioorg.Med.Chem.Lett

      Volume: 22 Pages: 2470-2473

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Journal Article] Short-RNA Selective Binding of Oligonucleotides Modified Using Adenosine and Guanosine Derivatives That Possess Cyclohexyl Phosphates as Substituents2012

    • Author(s)
      Seio, K.; Kurohagi, S.;Kodama, E.;Tsunoda, H.;Ohkubo, A.; Sekine, M
    • Journal Title

      Org. Biomol. Chem

      Volume: 10 Pages: 994-1006

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Journal Article] DNA Duplexes and Triplex-Forming Oligodeoxynucleotides Incorporating Modified Nucleosides Forming Stable and Selective Triplexes2012

    • Author(s)
      T.; Masaki, Y.; Mizuta, M.; Tsunoda, H.;Ohkubo, A.;Sekine, M.;Seio, K
    • Journal Title

      Org. Biomol. Chem

      Volume: 10 Pages: 1007-1013

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Journal Article] Synthesis and Properties of Oligoribonucleotides Having 5'-Terminal 2,2,7-Trimethylguanosine Cap Analogues2011

    • Author(s)
      Ohkubo, A.;Yokouchi, A.;Yamada, K.;Tsunoda, H.;Seio, K.; Sekine, M
    • Journal Title

      Nucleic Acids Therapeutics

      Volume: 21

    • DOI

      10.1089/nat.2011.1502

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Journal Article] Synthesis of 2'-O-[ 2-(N-Methylcarbamoyl) ethyl] ribonucl eosides Using Oxa-Michael Reaction and Chemical and Biological Properties of Oligonucleotide Derivatives Incorporating These Modified Ribonucleosides2011

    • Author(s)
      T. Yamada, N. Okaniwa, H. Saneyoshi, A. Ohkubo, K. Seio, T. Nagata, Y. Aoki, S. Takeda, and M. Sekine
    • Journal Title

      J. Org. Chem

      Volume: 76巻 Pages: 3042-3053

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Journal Article] Synthesis and Hybridization Properties of 2'-O-Methylated Oligoribonucleotides Incorporating 2'-O-Naphthyluridines2011

    • Author(s)
      M. Sekine, Y. Oeda, Y. Iijima, H. Taguchi, A. Ohkubo, and K. Seio
    • Journal Title

      Org. Biomol. Chem

      Volume: 9巻 Pages: 210-218

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Journal Article] Synthesis and Hybridization Properties of 2'-0-Methylated Oligoribonucleotides Incorporating 2'-0-Naphthyluridines2011

    • Author(s)
      M.Sekine, et al.
    • Journal Title

      Org.Biomol.Chem.

      Volume: 76 Pages: 210-218

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Journal Article] Synthesis and Hybridization Properties of 2'-O-Methylated Oligoribonucleotides Incorporating 2'-O-Naphthyluridines2011

    • Author(s)
      M.Sekine, et al.
    • Journal Title

      Org.Biomol.Chem.

      Volume: 76 Pages: 210-218

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Journal Article] Stable Triplex Formation Using the Strong Stacking Effect of Consecutive Thionucleoside Moieties Incorporated into Triplex-forming Oligonucleotides2011

    • Author(s)
      Ohkubo, A.; Nishino, Y.; Yokouchi, A.; Ito, Y.; Noma, Y.;Tsunoda, H.;Sekine, M
    • Journal Title

      Chem. Commun

      Volume: 47 Pages: 12556-12558

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Journal Article] Synthesis of 6-N-(Benzothiazol-2-yl) deoxyadenosine and Its Exciton-coupled Circular Dichroism2010

    • Author(s)
      Y. Masaki, A. Ohkubo, K. Seio, and M. Sekine
    • Journal Title

      Bioorg. Med. Chem

      Volume: 18巻 Pages: 567-572

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Journal Article] Linear Relationship between Deformability and Thermal Stability of 2'-O-Modified RNA Hetero Duplexes2010

    • Author(s)
      Y.Masaki, R.Miyasaka, A.Ohkubo, K.Seio, M.Sekine
    • Journal Title

      J.Phys.Cheer.(B) 114

      Pages: 2517-2524

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Journal Article] Linear Relationship between Deformability and Thermal Stability of 2'-O-Modified RNA Hetero Duplexes2010

    • Author(s)
      Y. Masaki, R. Miyasaka, A. Ohkubo, K. Seio, and M. Sekine
    • Journal Title

      J. Phys. Chem.(B)

      Volume: 114巻 Pages: 2517-2524

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Journal Article] Linear Relationship between Deformability and Thermal Stability of 2'-O-Modified RNA Hetero Duplexes2010

    • Author(s)
      Y.Masaki, R.Miyasaka, A.Ohkubo, K.Seio, M.Sekine
    • Journal Title

      J.Phys.Chem.(B) 114

      Pages: 2517-2524

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Journal Article] Efficient solid-phase synthesis of oligodeoxynucleotides having a 5'-terminal 2,2,7-trimethylguanosine pyrophosphate linkage2009

    • Author(s)
      A.Ohkubo, K.Sasaki, Y.Noma, H.Tsunoda, K.Seio, M.Sekine
    • Journal Title

      Bioorg.Med.Chem. 17

      Pages: 4819-4824

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Journal Article] Introduction of 3'-Terminal Nucleosides Having a Silyl Linker into Polymer Supports without Base Protection2009

    • Author(s)
      A.Ohkubo, Y.Noma, K.Aoki, H.Tsunoda, K.Seio, M Sekine
    • Journal Title

      J.Org.Chem. 74

      Pages: 2817-2823

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Journal Article] Synthesis and Properties of Nucleoside Derivatives Masked by the Chemically Stable 2-(Trimethylsilyl) benzoyl Group2009

    • Author(s)
      K. Yamada, H. Taguchi, A. Ohkubo, K. Seio, and M. Sekine
    • Journal Title

      Bioorg. Med. Chem

      Volume: 17巻 Pages: 5928-5932

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Journal Article] Microwave-Assisted Synthesis of 2'-O-Aryluridine Derivatives2009

    • Author(s)
      Y.Oeda, Y.Iijima, H.Taguchi, A.Ohkubo, K.Seio, M.Sekine
    • Journal Title

      Org.Lett. 11

      Pages: 5582-5585

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Journal Article] Synthesis and hybridization of 2'-O-methyl-RNAs incorporating 2'-O-carbamoyluridine and unique participation of the carbamoyl group in U. G base pair2009

    • Author(s)
      K. Seio, R. Tawarada, T. Sasami, M. Serizawa, M. Ise, A. Ohkubo, and M. Sekine
    • Journal Title

      Bioorg. Med. Chem

      Volume: 17巻 Pages: 7275-7280

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Journal Article] Synthesis and hybridization of 2'-O-methyl-RNAs incorporating 2'-O-carbamoyluridine and unique participation of the carbamoyl group in U-G base pair2009

    • Author(s)
      K.Seio, R.Tawarada, T.Sasami, M.Serizawa, M.Ise, A.Ohkubo, M.Sekine
    • Journal Title

      Bioorg.Med.Chem. 17

      Pages: 7275-7280

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Journal Article] icrowave-Assisted Synthesis of 2'-O-Aryluridine Derivatives2009

    • Author(s)
      Y. Oeda, Y. Iijima, H. Taguchi, A. Ohkubo, K. Seio, and M. Sekine
    • Journal Title

      Org. Lett

      Volume: 11巻 Pages: 5582-5585

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Journal Article] Efficient solid-phase synthesis of oligodeoxynucleotides having a 5'-terminal 2, 2, 7-trimethylguanosine pyrophosphate linkage2009

    • Author(s)
      A.Ohkubo, K.Sasaki, Y.Noma, H.Tsunoda, K.Seio, M.Sekine
    • Journal Title

      Bioorg.Med.Chem. 17

      Pages: 4819-4824

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Journal Article] 3'-Terminal Nucleosides Having a SilylLinker into Polymer Supports without Base Protection2009

    • Author(s)
      A. Ohkubo, Y. Noma, K. Aoki, H. Tsunoda, K. Seio and M. Sekine
    • Journal Title

      J. Org. Chem

      Volume: 74巻 Pages: 2817-2823

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Journal Article] Synthesis and Properties of Nucleoside Derivatives Masked by the Chemically Stable 2-(Trimethylsilyl)benzoyl Group2009

    • Author(s)
      K.Yamada, H.Taguchi, A.Ohkuho, K.Seio, M.Sekine
    • Journal Title

      Bioorg.Med.Chem. 17

      Pages: 5928-5932

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Journal Article] Microwave-Assisted Synthesis of 2'-O-Aryluridine Derivatives2009

    • Author(s)
      Y.Oeda, Y.Iijima, H.Taguchi, A.Ohkubo, K.Seio, M.Sekine
    • Journal Title

      Org.Lett. 11

      Pages: 5582-5585

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Journal Article] Synthesis and hybridization of 2'-O-methyl-RNAs incorporating 2'-O-carbamoyluridine and unique participation of the carbamoyl group in U-G base pair2009

    • Author(s)
      K.Seio, R.Tawarada, T.Sasami, M.Serizawa, M.Ise, A.Ohkubo, M.Sekine
    • Journal Title

      Bioorg.Med.Chem. 17

      Pages: 7275-7280

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Journal Article] Synthesis of terminally modified oligonucleotides and their hybridization dependence on the size of the target RNAs2009

    • Author(s)
      K.Seio, Y.Takaku, K.Miyazaki, Y.Masaki, A.Ohkubo, M.Sekine
    • Journal Title

      Org.Biomol.Chem. 7

      Pages: 2440-2451

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Journal Article] Synthesis of terminally modified oligonucleotides and their hybridization dependence on the size of the target RNAs2009

    • Author(s)
      K.Seio, Y.Takaku, K.Miyazaki, Y.Masaki, A.Ohkubo, M.Sekine
    • Journal Title

      Org.Biomol.Chem. 7

      Pages: 2440-2451

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Journal Article] Synthesis of terminally modifiedoligonucleotides and their hybridization dependence on the size of the target RNAs2009

    • Author(s)
      K. Seio, Y. Takaku, K. Miyazaki, Y. Masaki, A. Ohkubo, and M. Sekine
    • Journal Title

      Org. Biomol. Chem

      Volume: 7巻 Pages: 2440-2451

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Journal Article] Synthesis and Properties of Nucleoside Derivatives Masked by the Chemically Stable 2-(Trimethylsilyl) benzoyl Group2009

    • Author(s)
      K.Yamada, H.Taguchi, A.Ohkubo, K.Seio, M.Sekine
    • Journal Title

      Bioorg.Med.Chem. 17

      Pages: 5928-5932

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Journal Article] Introduction of 3'-Terminal Nucleosides Having a Silyl Linker into Polymer Supports without Base Protection2009

    • Author(s)
      A.Ohkubo, Y.Noma, K.Aoki, H.Tsunoda, K.Seio, M.Sekine
    • Journal Title

      J.Org.Chem. 74

      Pages: 2817-2823

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Journal Article] Efficient solid-phase synthesis of oligodeoxynucleotides having a 5'-terminal 2, 2, 7-trimethylguanosine pyrophosphate linkage2009

    • Author(s)
      A. Ohkubo, K. Sasaki, Y. Noma, H. Tsunoda, K. Seio, and M. Sekine
    • Journal Title

      Bioorg. Med. Chem

      Volume: 17巻 Pages: 4819-4824

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Presentation] 核酸医薬を指向した修飾オリゴヌクレオチドの創成2015

    • Author(s)
      関根光雄
    • Organizer
      日本薬学会
    • Place of Presentation
      神戸学院大学神戸
    • Year and Date
      2015-03-29
    • Invited
    • Data Source
      KAKENHI-PROJECT-26560434
  • [Presentation] 核酸医薬を指向した修飾オリゴヌクレオチドの創成2015

    • Author(s)
      関根光雄
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2015-03-28
    • Invited
    • Data Source
      KAKENHI-PROJECT-25288074
  • [Presentation] 遺伝子制御機能をもつ人工核酸の合成研究2015

    • Author(s)
      関根光雄
    • Organizer
      日本化学会第95春季年会
    • Place of Presentation
      日本大学理工学部  船橋キャンパス/薬学部
    • Year and Date
      2015-03-29
    • Invited
    • Data Source
      KAKENHI-PROJECT-25288074
  • [Presentation] 遺伝子制御機能をもつ人工核酸の合成研究2015

    • Author(s)
      関根光雄
    • Organizer
      日本化学会
    • Place of Presentation
      日本大学理工学部
    • Year and Date
      2015-03-29
    • Invited
    • Data Source
      KAKENHI-PROJECT-26560434
  • [Presentation] 筋ジストロフィー治療を指向した塩基部修飾2'-0-MCE RNAの合成と性質2014

    • Author(s)
      石井陽大,正木慶昭,山田剛史,岡庭夏己,永田哲也,武田伸一,金森功吏,大窪章寛,清尾康志,関根光雄
    • Organizer
      第94回春季年会プログラム
    • Place of Presentation
      名古屋大学 東山キャンパス
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] 3-アミノピリダジン型核酸塩基を有するペプチド核酸の合成と性質2014

    • Author(s)
      友利貴人,宮武佑弥,佐藤祐太,金森功吏,正木慶昭,大窪章寛,関根光雄,清尾康志
    • Organizer
      第94春季年会プログラム
    • Place of Presentation
      名古屋大学 東山キャンパス
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] Sutudies of Modified Oligonucleotides Directed toward Nucleic Acid Drugs2014

    • Author(s)
      Mitsuo Sekine
    • Organizer
      Mini-Symposium on Frontiers of Nucleic Acid Therapeutics
    • Place of Presentation
      Lodz, Poland
    • Year and Date
      2014-09-01
    • Invited
    • Data Source
      KAKENHI-PROJECT-25288074
  • [Presentation] GFPクロモフォアを導入したDNA三重鎖の蛍光増強を目指した構造探索2014

    • Author(s)
      金森功吏,高村亮宏,正木慶昭,大窪章寛,関根光 雄,清尾康志
    • Organizer
      第94春季年会プログラム
    • Place of Presentation
      名古屋大学 東山キャンパス
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] New Approach to the Synthesis of Modified Oligonucleotides. Contemporary Snapshot of Nucleic Acids Mini-symposium Dedicated to honour Professor Collin B. Reese for his contributions in the area of nucleic acids research2014

    • Author(s)
      Mitsuo Sekine
    • Organizer
      Contemporary Snapshot of Nucleic Acids Mini-symposium Dedicated to honour Professor Collin B. Reese for his contributions in the area of nucleic acids research
    • Place of Presentation
      Polish Academy of Sciences, Poznan, Poland
    • Year and Date
      2014-08-24
    • Invited
    • Data Source
      KAKENHI-PROJECT-25288074
  • [Presentation] デオキシシュードイソシチジンと5-メチル -4-ピリミジノンヌクレオシドを導入したDNA 三重鎖の塩基対形成能の評価2014

    • Author(s)
      山口慧, 金森功吏,正木慶昭,大窪章寛,関根光 雄,清尾康志
    • Organizer
      第94回春季年会プログラム
    • Place of Presentation
      名古屋大学, 東山キャンパス
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] イミダゾリノン誘導体を導入した新規蛍光核酸の合成と蛍光特性2013

    • Author(s)
      金森功吏,高村亮宏,大窪章寛,関根光雄,清尾康志
    • Organizer
      第93春季年会プログラム
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] 4-(2-グアニドエチル)ピリミジン誘導体を含む三重鎖形成核酸の合成と塩基識別能2013

    • Author(s)
      伊藤優,大窪章寛,山田健司,吉村貴一,金森功吏,正木慶昭,清尾康志,関根光雄
    • Organizer
      第93春季年会プログラム
    • Place of Presentation
      立命館大学びわこ・くさっキャンパス
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] 新規 2′-O-修飾 RNA の開発とそのエキソン・スキッピング 活性2013

    • Author(s)
      関根光雄
    • Organizer
      第15回日本RNA学会年会
    • Place of Presentation
      愛媛県・県民文化会館ひめぎんホール
    • Invited
    • Data Source
      KAKENHI-PROJECT-25288074
  • [Presentation] 塩基部修飾を導入した2'-0-[2-(N-メチルカルバモイル)エチル]修飾核酸の合成とその性質2013

    • Author(s)
      石井陽大、正木慶昭、劉天文、田胡信広、岡庭夏己、山田剛史、永田哲也、武田 伸一、金森功吏、大窪章寛、清尾康志、関根光雄
    • Organizer
      第23回アンチセンスシンポジウム
    • Place of Presentation
      徳島大学蔵本キャンパス
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] 新規 2′-O-修飾 RNA の開発とそのエキソン・スキッピング 活性2013

    • Author(s)
      関根光雄
    • Organizer
      第15回日本RNA学会年会
    • Place of Presentation
      愛媛県・県民文化会館ひめぎんホール
    • Invited
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] 四塩基対認識を指向した人工三重鎖形成核酸の合成と性質2013

    • Author(s)
      山田健司,大窪章寛,伊藤優,吉村貴一,金森功吏,正木慶昭,清尾康志,関根光雄
    • Organizer
      第93春季年会プログラム
    • Place of Presentation
      立命館大学びわこ・くさっキャンパス
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] T-A, C-G塩基対を含む配列で認識可能な新規三重鎖形成核酸の合成2013

    • Author(s)
      伊藤優、大窪章寛、山田健司、吉村貴一、金森功吏、正木慶昭、清尾康志、関根光雄
    • Organizer
      第23回アンチセンスシンポジウム
    • Place of Presentation
      徳島大学 蔵本キャンパス
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] Synthesis and properties of new triplex forming oligonucleotides capable of recognizing TA and CG base pair in parallel orientation2012

    • Author(s)
      Kenji Yamada, Yu Ito, Kiichi Yoshimura, Takashi Kanamori, Akihiro Ohkubo, Kohji Seio, Mitsuo Sekine
    • Organizer
      The 39th International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      Nagoya University(IGER)
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] チオカルボニル基を有する修飾塩基の連続導入による三重鎖形成能の向上2012

    • Author(s)
      山田健司,服部勇作,印出健志,金森功吏,大窪章寛,清尾康志,関根光雄
    • Organizer
      アンチセンス・遺伝子・デリバリーシンポジウム
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] Design and Synthesis of New Oligonucleotides Capable of Forming Triplexes Highly Selectively with DNA Duplexes without Binding to Single Stranded mRNAs2012

    • Author(s)
      関根光雄
    • Organizer
      2012 International Symposium on Advanced Biological Engineering (ISABE'2012)
    • Place of Presentation
      Guilin, Guangxi, China(桂林)
    • Year and Date
      2012-10-25
    • Invited
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] 6-チオプリンおよび4-チオピリミジン誘導体を含むオリゴヌクレオチドの合成とその三重鎖形成能2012

    • Author(s)
      服部勇作・印出健志・山田健司・伊藤優・角田浩佑・大窪章寛・清尾康志・関根光雄
    • Organizer
      第92春季年会
    • Place of Presentation
      慶應大学
    • Year and Date
      2012-03-25
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Presentation] DNA二重鎖および三重鎖に導入したデオキシシュードイソシチジンの塩基対形成能の評価2012

    • Author(s)
      金森功吏・山口慧・角田浩佑・大窪章寛・関根光雄・清尾康志
    • Organizer
      第92春季年会
    • Place of Presentation
      慶應大学
    • Year and Date
      2012-03-25
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Presentation] 4-O-(アミノエチル)ウリジン誘導体を含む新規三重鎖形成核酸の合成とその性質2012

    • Author(s)
      伊藤優・山田健司・角田浩佑・大窪章寛・清尾康志・関根光雄
    • Organizer
      第92春季年会
    • Place of Presentation
      慶應大学
    • Year and Date
      2012-03-25
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Presentation] 2,2,7-トリメチルグアノシンキャップ構造およびそのアナログ構造を有するアンチセンス分子の合成と性質2011

    • Author(s)
      横内瑛,山田研,鈴木真,角田浩佑,大窪章寛,清尾康志,関根光雄
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場「エポカルつくば」
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] 4-0-(アミノエチル)ウリジン誘導体を含む新規三重鎖形成核酸の合成とその性質2011

    • Author(s)
      伊藤優,西野雄大,角田浩佑,大窪章寛,清尾康志,関根光雄
    • Organizer
      第92春季年会プログラム
    • Place of Presentation
      慶磨大学日吉キャンパス・矢上キャンパス
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] Synthesis and Properties of Oligonucleotides 2,2,7-Trimethyl- guanosine Cap Analogues2011

    • Author(s)
      Yokouchi, A.; Yamada, K.;Tsunoda, H.;Ohkubo, A.; Seio, K.;Sekine, M
    • Organizer
      2011 International Graduate Forum on Biotechnology, Bioengineering and Biomedical Science
    • Place of Presentation
      北京
    • Year and Date
      2011-08-27
    • Invited
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] 新規人工核酸の創成研究2011

    • Author(s)
      関根光雄
    • Organizer
      日本化学会関東支部主催群馬地区講演会
    • Place of Presentation
      群馬大学
    • Year and Date
      2011-07-08
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Presentation] 6-チオプリンおよび4一チオピリミジン誘導体を含むオリゴヌクレオチドの合成とその三重鎖形成能2011

    • Author(s)
      服部勇作,印出健志,山田健司,伊藤優,角田浩佑,大窪章寛,清尾康志,関根光雄
    • Organizer
      第92春季年会プログラム
    • Place of Presentation
      慶慮大学日吉キャンパス・矢上キャンパス
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] Recent Studies on the Chemical Synthesis on Modified RNA OIigomers Directed towawd Genen Therapy2011

    • Author(s)
      Sekine, M
    • Organizer
      International Graduate Forum on Biotechnology, Bioengineering and Biomedical Science
    • Place of Presentation
      北京
    • Year and Date
      2011-08-27
    • Invited
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] Synthesis and Properties of Oligonucleotides Having 5'-Termina1 2,2,7-Trimethylguanosine Cap Analogues2011

    • Author(s)
      Yokouchi, A.;Yamada, K.;Tsunoda, H.; Ohkubo, A.;Seio, K.;Sekine, M
    • Organizer
      The 16th Annual Meeting of the RNA Society and The RNA Society of Japan 13th Annual Meeting
    • Place of Presentation
      国立京都国際会館
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] 新規人工核酸の創成研究2011

    • Author(s)
      関根光雄
    • Organizer
      日本化学会関東支部主催群馬地区講演会
    • Place of Presentation
      群馬大学(招待講演)
    • Year and Date
      2011-07-08
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Presentation] Synthesis and Triplex Formation of RNAs Containing 8-Thioxoadenine and 2-Thiopyrimidine2011

    • Author(s)
      Ohkubo, A.;Ito, Y.; Nishino, Y.;Yokouchi, A.;Tsunoda, H.; Seio, K.;Sekine, M
    • Organizer
      The 16th Annual Meeting of the RNA Society and The RNA Society of Japan 13th Annual Meeting
    • Place of Presentation
      国立京都国際会館
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] Synthesis and Biological Properties of Synthesis and Biological Properties of 2'-O-Modified Oligoribonucleotide Derivatives2011

    • Author(s)
      Sekine, M.
    • Organizer
      XVth Symposium on Chemistry of Nucleic Acid Components SCNAC 2011
    • Place of Presentation
      Cechy, Ceska republika(招待講演)
    • Year and Date
      2011-06-09
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] ホスホロアミダイト化合物を利用したオリゴヌクレオチド5'末端の新規アデニル化反応2011

    • Author(s)
      田胡信広,西野雄大,角田浩佑,大窪章寛,清尾康志,関根光雄
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場「エポカルつくば」
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] 1-アミノフタラジンを有する新規ペプチド核酸の合成2011

    • Author(s)
      佐藤祐太,金森功吏,角田浩佑,大窪章寛,関根光雄,清尾康志
    • Organizer
      第1回CSJ化学フェスタ2011世界化学年祈年大会
    • Place of Presentation
      早稲田大学大隈記念講堂・小野梓記念館
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] 3-メチルベンゾフランを導入したウリジン誘導体の合成と二重鎖構造及び三重鎖構造中での蛍光特性2011

    • Author(s)
      金森功吏,大関弘貴,徳川宗史,角田浩佑,大窪章寛,関根光雄,清尾康志
    • Organizer
      第92春季年会プログラム
    • Place of Presentation
      慶磨大学日吉キャンパス・矢上キャンパス
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] Synthesis and Biological Properties of Synthesis and Biological Properties of 2'-O-Modified Oligoribonucleotide Derivatives2011

    • Author(s)
      Sekine, M.
    • Organizer
      XVth Symposium on Chemistry of Nucleic Acid Components SCNAC 2011
    • Place of Presentation
      Cechy, Ceska republika(招待講演)
    • Year and Date
      2011-06-09
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Presentation] アミノナフチリジン誘導体を含む新規三重鎖形成核酸の合成とその性質2011

    • Author(s)
      山田健司,服部勇作,伊藤優,印出健志,角田浩佑,大窪章寛,清尾康志,関根光雄
    • Organizer
      第92春季年会プログラム
    • Place of Presentation
      慶慮大学日吉キャンパス・矢上キャンパス
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] Synthesis and Biological Properties of Synthesis and Biological Properties of 2'-O-Modified Oligoribonucleotide Derivatives2011

    • Author(s)
      M. Sekine
    • Organizer
      XVth Symposium on Chemistry of Nucleic Acid Components SCNAC 2011
    • Place of Presentation
      Cechy, eska republika
    • Year and Date
      2011-06-09
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Presentation] マイクロフローリアクターを利用した修飾ヌクレオチドの新規合成法の開発2011

    • Author(s)
      田胡信広,角田浩佑,大窪章寛,清尾康志,関根光雄
    • Organizer
      第92春季年会プログラム
    • Place of Presentation
      慶慮大学日吉キャンパス・矢上キャンパス
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] TMGキャップアナロクを有するモルフォリノ核酸の合成2011

    • Author(s)
      山田研・横内瑛・鈴木真・角田浩佑・大窪章寛・清尾康志・関根光雄
    • Organizer
      第21回アンチセンスシンポジウムおよび第11回遺伝子・デリバリー研究会シンポジウム
    • Place of Presentation
      大阪大学コンベンションセンター
    • Year and Date
      2011-09-01
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Presentation] An Effective Method for Phosphorodiamidate Bond Formation in the Synthesis of Morpholino Nucleic Acids2011

    • Author(s)
      Harakawa, T.; Ishii, A.; Tsunoda, H.; Ohkubo, A.;Seio, K.;Sekine, M
    • Organizer
      The 28th International Symposium on Nucleic Acid Chemistry(ISNAC2011)
    • Place of Presentation
      Clark Memorial Student Center, Hokkaido University, Japan
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] Synthesis and Properties of Oligonucleotides 2,2,7-Trimethylguano-sine Cap Analogues2011

    • Author(s)
      Ohkubo, A.; Yokouchi, A.;Yamada, K.;Tsunoda, H.; Seio, K.;Sekine, M
    • Organizer
      6^<th> Cambridge Symposium on Nucleic Acids Chemistry and Biolo
    • Place of Presentation
      Queens'College, Cambridge, UK
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] 新合成手法に基づく新規核酸医薬の開発2011

    • Author(s)
      関根光雄
    • Organizer
      千里ライフサイエンスセミナー
    • Place of Presentation
      千里
    • Year and Date
      2011-07-08
    • Invited
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] Synthesis and Biological Properties of 2'-O-Modified Oligoribonucleotide Derivatives2011

    • Author(s)
      Sekine, M
    • Organizer
      XVth Symposium on Chemistry of Nucleic Acid Components SCNAC 2011
    • Place of Presentation
      Cechy, Ceska republika
    • Invited
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] 生体関連核酸誘導体の効率的合成法に関する研究2011

    • Author(s)
      関根光雄
    • Organizer
      第92春季年会プログラム
    • Place of Presentation
      慶磨大学日吉キャンパス・矢上キャンパス
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] DNA二重鎖および三重鎖に導入したデオキシシュードイソシチジンの塩基対形成能の評価2011

    • Author(s)
      金森功吏,山口慧,角田浩佑,大窪章寛,関根光雄,清尾康志
    • Organizer
      第92春季年会プログラム
    • Place of Presentation
      慶慮大学日吉キャンパス・矢上キャンパス
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] One-pot Sequential Formation of Pyro- and Triphosphate Bonds by Using O-N Phosphoryl Migration of Phosphoramidite Derivatives2011

    • Author(s)
      Tago, N.;Ohkubo, A.;Tsunoda, H.;Seio, K.;Sekine, M
    • Organizer
      The Seventh International Symposium on Integrated Syntheaia(ISIS-7)
    • Place of Presentation
      Seaside Hotel Maiko Vill, Kobe, Japan
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] TMGキャップアナロクを有するモルフォリノ核酸の合成2011

    • Author(s)
      山田研,横内瑛,鈴木真,角田浩佑,大窪章寛,清尾康志,関根光雄
    • Organizer
      第21回アンチセンスシンポジウムおよび第11回遺伝子・デリバリー研究会シンポジウム
    • Place of Presentation
      大阪大学コンベンションセンター
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] 新規人工核酸の創成研究2011

    • Author(s)
      関根光雄
    • Organizer
      日本化学会関東支部主催群馬地区講演会
    • Place of Presentation
      群馬大学
    • Year and Date
      2011-06-20
    • Invited
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] 新規人工核酸の創成研究2011

    • Author(s)
      関根光雄
    • Organizer
      日本化学会関東支部主催群馬地区講演会
    • Place of Presentation
      群馬大学(招待講演)
    • Year and Date
      2011-07-08
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] 2-チオピリミジンおよび8-チオキソプリンを含む修飾核酸の三重鎖形成能2011

    • Author(s)
      伊藤優,西野雄大,角田浩佑,大窪章寛,清尾康志,関根光雄
    • Organizer
      第1回CSJ化学フェスタ2011世界化学年祈年大会
    • Place of Presentation
      早稲田大学大隈記念講堂・小野梓記念館
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] Synthesis and Properties of Oligonucleotides Having 2,2,7-Trimethylguanosine Cap Analogs2011

    • Author(s)
      Yamada, K.;Yokouchi, A.;Suzuki, M.; Tsunoda, H.;Ohkubo, A.;Seio, K.;Nagata, T.;Aoki, Y.;Takeda, S.;Sekine, M
    • Organizer
      The 28^<th> International Symposium on Nucleic Acid Chemistry (ISNAC2011)
    • Place of Presentation
      Clark Memorial Student Center, Hokkaido University, Japan
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] S-フェニルポスホロチオエート誘導体を利用した、固相上でのTMG-キャップ化反応の検討2011

    • Author(s)
      山田研,鈴木真,横内瑛,角田浩佑,大窪章寛,清尾康志,関根光雄
    • Organizer
      第92春季年会プログラム
    • Place of Presentation
      慶磨大学日吉キャンパス・矢上キャンパス
    • Year and Date
      2011-03-25
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] Oligonucleotides 2,2,7-Trimethylguano- sine Cap Analogues2011

    • Author(s)
      Ohkubo, A.; Yokouchi, A.;Yamada, K.;Tsunoda, H.; Seio, K.;Sekine, M
    • Organizer
      7^<th> Annual Meeting of the Oligonucleotide Therapeutics Society
    • Place of Presentation
      The Royal Library, Copenhagen, Denmark
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] 2'-O-カルハモイルウリシン誘導体を有する人工核酸の合成と性質2011

    • Author(s)
      徳川宗史,角田浩佑,大窪章寛,清尾康志,関根光雄
    • Organizer
      第21回アンチセンスシンポジウムおよび第11回遺伝子・デリバリー研究会シンポジウム
    • Place of Presentation
      大阪大学コンベンションセンター
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] New Triplex Forming Oligonucleotides Capable of Binding to DNA Duplexes under Neutral Conditions2010

    • Author(s)
      M.Sekine
    • Organizer
      Heidelberg University-Tokyo Institute of Technology Joint Symposium on
    • Place of Presentation
      Wroclaw University, Poland
    • Year and Date
      2010-07-16
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] 2'-O-MCEオリゴヌクレオチドの合成と性質2010

    • Author(s)
      山田剛史、岡庭夏己、武田伸一、永田哲也、實吉尚郎、大窪章寛、関根光雄
    • Organizer
      第20回アンチセンスシンポジウム
    • Place of Presentation
      甲南大学
    • Year and Date
      2010-12-02
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Presentation] Relationship Between Thermal Stability and Deformability of Modified RNA, XIX International Round Table on Nucleosides2010

    • Author(s)
      正木慶昭・宮坂隆太・角田浩佑・大窪章寛・清尾康志・関根光雄
    • Organizer
      Nucleotides and Nucleic Acids
    • Place of Presentation
      クロードベルナールリヨン第一大学
    • Year and Date
      2010-09-01
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Presentation] Triplex Forming Oligonucleotides Containing Thiolated Nucleobases2010

    • Author(s)
      M.Sekine
    • Organizer
      ICPC2010-Symposium on Biophosphates
    • Place of Presentation
      Wroclaw Lniversity, Poland
    • Year and Date
      2010-07-13
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] Triplex Forming ligonucleotides Containing Thiolated Nucleobases2010

    • Author(s)
      M. Sekine
    • Organizer
      ICPC2010-Symposium on Biophosphates
    • Place of Presentation
      Wroclaw University, Poland
    • Year and Date
      2010-07-16
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Presentation] Synergetic effects of 2-thiolation and 5-propynylation of the uracil base on the stability of RNA duplexes2010

    • Author(s)
      R. Miyasaka, Y. Masaki, H. Tsunoda, A. Ohkubo, K. Seio, and M. Sekine
    • Organizer
      第37回国際核酸化学シンポジウム
    • Place of Presentation
      よこはま・はまぎんホール
    • Year and Date
      2010-11-10
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Presentation] Triplex Forming Oligonucleotides Containing Thiolated Nucleobases2010

    • Author(s)
      M.Sekine
    • Organizer
      ICPC2010-Symposium on Biophosphates
    • Place of Presentation
      Wroclaw University, Poland
    • Year and Date
      2010-07-13
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Presentation] New Triplex Forming Oligonucleotides Capable of Binding to DNA Duplexes under Neutral Conditions2010

    • Author(s)
      M. Sekine
    • Organizer
      Heidelberg University-Tokyo Institute of Technology Joint Symposium on
    • Place of Presentation
      Wroclaw University, Poland
    • Year and Date
      2010-07-16
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Presentation] 新規核酸医薬の創成を指向した合成研究2010

    • Author(s)
      関根光雄
    • Organizer
      第54回日本薬学会関東支部大会
    • Place of Presentation
      東京薬科大学
    • Year and Date
      2010-10-02
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] Synthesis and Properties of Modified Oligonucleotides Capable Triplex Formation with DNA Duplexes under Neutral Conditions2010

    • Author(s)
      M.Sekine
    • Organizer
      2010環太平洋国際化学会議
    • Place of Presentation
      Hawaii, Convention Center, USA
    • Year and Date
      2010-12-15
    • Data Source
      KAKENHI-PLANNED-21106007
  • [Presentation] Synthesis and Properties of 2'-O-[ 2-(N-methyl) carbamoyl] ethyl-RNAs2010

    • Author(s)
      T. Yamada, N. Okaniwa, H. Saneyoshi, A. Ohkubo, K. Seio, T. Nagata, S. Takeda, and M. Sekine
    • Organizer
      第37回国際核酸化学シンポジウム
    • Place of Presentation
      よこはま・はまぎんホール
    • Year and Date
      2010-11-10
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Presentation] Synthesis and Properties of Modified Oligonucleotides Capable Triplex Formation with DNA Duplexes under Neutral Conditions2010

    • Author(s)
      M. Sekine
    • Organizer
      2010環太平洋国際化学会議
    • Place of Presentation
      Hawaii, Convention Center, USA
    • Year and Date
      2010-12-15
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Presentation] 新規核酸医薬の創成を指向した合成研究2010

    • Author(s)
      関根光雄
    • Organizer
      第54回日本薬学会関東支部大会
    • Place of Presentation
      東京薬科大学
    • Year and Date
      2010-10-02
    • Data Source
      KAKENHI-PROJECT-21241053
  • [Presentation] Design and synthesis of fluorescent nucleosides for the development of oligonucleotides capable of emitting fluorescence upon formation of nucleic acid structures

    • Author(s)
      Mitsuo Sekine
    • Organizer
      FB3 Fluorescent Biomolecules and Their Building Blocks-Design and Applications
    • Place of Presentation
      UC San Diego, USA
    • Year and Date
      2014-08-06 – 2014-08-09
    • Invited
    • Data Source
      KAKENHI-PROJECT-25288074
  • [Presentation] Synthesis and Properties of Base or Sugar Modified RNA Derivatives

    • Author(s)
      Mitsuo Sekine
    • Organizer
      XVIth Symposium on Chemistry of Nucleic Acid Components SCNAC 2014
    • Place of Presentation
      Cesky Krumlov, Czech Republic
    • Year and Date
      2014-06-08 – 2014-06-12
    • Invited
    • Data Source
      KAKENHI-PROJECT-25288074
  • [Presentation] Studies on modified oligonucleotides capable of precise recognition and strong binding affinity for target nucleic acids

    • Author(s)
      Mitsuo Sekine
    • Organizer
      The 41th International Symposium on Nucleic Acid Chemistry
    • Place of Presentation
      Kitakyushu International Conference Center
    • Year and Date
      2014-11-05 – 2014-11-07
    • Invited
    • Data Source
      KAKENHI-PROJECT-25288074
  • 1.  HATA Tsujiaki (00016049)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 2.  金子 主税 (40013833)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 3.  松田 彰 (90157313)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 4.  大塚 栄子 (80028836)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 5.  HAYAKAWA Yoshihiro (50022702)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 6.  WADA Takeshi (90240548)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 7.  佐々木 琢磨 (90109976)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  ISHIKAWA Masahide (50212858)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  小林 進 (70101102)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  向山 光昭 (60016003)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  OHKUBO Akihiro (60376960)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 39 results
  • 12.  NISHINA Kikuko (40198479)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  KAGAWA Toshiharu (50108221)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  NAKAHAMA Seiich (90016410)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  KUMURA Tsutomu (40016506)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  MAKINO Keisuke (50159141)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  SEIO Khoji (20313356)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  西村 善文 (70107390)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  綿矢 有佑 (90127598)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  渋谷 雅之 (40027066)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  高久 洋 (50101267)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  石戸 良治 (60016037)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  上田 亨 (00001032)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  谷口 すみ子 (30217129)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  KANEKO Mineo (00185935)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  西川 一八 (60109262)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  KIDA Masahide
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  KIMOTO Haruo
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  高橋 秀臣
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  正木 慶昭
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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