Wada Takeshi 和田猛

… Alternative Names

Researcher Number	90240548
Other IDs
External Links
Affiliation (Current)	2019: 東京理科大学, 薬学部生命創薬科学科, 教授
Affiliation (based on the past Project Information) *help	2016 – 2019: 東京理科大学, 薬学部生命創薬科学科, 教授 2015: 東京理科大学, 薬学部, 教授 2013: 東京理科大学, 薬学部, 教授 2012: 東京大学, 新領域創成科学研究科, 准教授 2009 – 2011: The University of Tokyo, 大学院・新領域創成科学研究科, 准教授 … More
Review Section/Research Field	Principal Investigator Bioorganic chemistry / Biological Sciences / Chemistry related to living body / Science and Engineering / Bio-related chemistry Except Principal Investigator 天然物有機化学 / Medical sociology / Bioorganic chemistry / 広領域 / Molecular biology / Biological Sciences / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 保護基 / アンチセンス核酸 / 固相合成 / 核酸医薬 / DNAアナログ / 不斉合成 / mRNA / H-ホスホネートDNA / siRNA / ホスホロチオエートRNA … More Except Principal Investigator RNA / ANTISENCE NUCLEIC ACID / SOLID PHASE SYNTHESIS / HIV / AMIDITE / アンチセンス核酸 / 2'-PHOSPHATE / ENZYME RESISTANCE / 環状シリルエーテル / 3'-endo / 浸潤・転移 / アカデミック・ディテーリング / エイズ / 6-チオグアノシン / 修飾RNA / アンチセンス / シクロヌクレオチド / 分子内環状化反応 / ANTISENCE NUCLEIC ACID RNA / 医薬品比較 / 固相合成 / 標識 / 化学発光 / シクロウリジル酸 / アミダイト法 / 縮合反応 / 2-AZIDODEOXYADENOSINE / 蛋白質 / CONFORMATION / アミダイト試薬 / 2-アジドデオイシアデノシン / 保護基 / 3′-endo / 分子力場計算 / U1 RNA / 固相合成法 / 6-チオイノシン / 2'、3'-リン酸基転移 / チオリン酸基 / リンカー / 4-チオウリジン / tRNA / ゲノム / 分子内水素結合 / アンチ核酸 / CHEMICAL SYNTHESIS / SYNTHETIC / PHOTOCROSSLINKING / 医薬品比較システム / DUPLEX FORMATION / 遺伝子治療 / 発現制御 / ホスホネート法 / SOLID PHASE / リン酸化 / ビオチン / 医薬品情報提供 / 医薬品情報提供アプローチ / 合成RNA / MODIFIED RNA / 酸素耐性 / 2'-リン酸化RNA / 光クロスリンク / 核酸製剤 / CYCLOURIDYLIC ACID / CHEMICALSYNTHESIS / 膵癌 / コンホメーション / 固相法 / H-ホスホネートDNA / MOLECULAR MECHANICS / 処方支援 / アミダイト / 酵素耐性 / 二重らせん形成 / INTRAMOLECULAR CYCLIZATION / U1RNA / 化学合成 / 3'-ENDO / 遺伝子 / 核酸 / TRANSFER RNA SYNTHESIS / 基礎薬学の臨床活用 / 塩基配列決定法 / 臨床薬剤師 / ジホスフェート / 2'-リン酸 Less

膵癌治療への実用化を目指した新規核酸化合物のマウスモデルを用いた作用機序の検討Ongoing
- Principal Investigator
  
  坪井麻記子
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kochi University
医薬品比較システム開発とそれを用いたアカデミック・ディテーリング効果に関する研究Ongoing
- Principal Investigator
  
  小茂田昌代
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical sociology
- Research Institution
  Tokyo University of Science
Molecule selection and optimization of highly active antisense DNA and determination of absolute configuration of phosphorus atomsPrincipal InvestigatorOngoing
- Principal Investigator
  
  和田猛
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Tokyo University of Science
Functional machinery for non-coding RNAs
- Principal Investigator
  
  TOMARI Yukihide
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Medicinal Application of Functional Machinery for non-coding RNAsPrincipal Investigator
- Principal Investigator
  
  WADA Takeshi
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo University of Science
  The University of Tokyo
Stereocontrolled synthesis of P-modified RNA nucleic acid drugsPrincipal Investigator
- Principal Investigator
  
  WADA Takeshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemistry related to living body
- Research Institution
  The University of Tokyo
New synthetic methods for the large scale synthesis of nucleic acid drugsPrincipal Investigator
- Principal Investigator
  
  WADA Takeshi
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemistry related to living body
- Research Institution
  The University of Tokyo
Synthesis and properties of novel artificial nucleic acid analogs having chiral backbonesPrincipal Investigator
- Principal Investigator
  
  WADA Takeshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  The University of Tokyo
ボラノホスフェートDNAを用いるHIV-nefタンパク質の発現制御Principal Investigator
- Principal Investigator
  
  和田猛
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Highly Efficient Synthesis of Artificial Nucleic Acids Having New FunctionsPrincipal Investigator
- Principal Investigator
  
  WADA Takeshi
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
修飾塩基を含むRNAの化学合成Principal Investigator
- Principal Investigator
  
  和田猛
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
新規アンチセンス核酸を用いるHIV-nefタンパク質の発現制御Principal Investigator
- Principal Investigator
  
  和田猛
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
修飾塩基を含むRNAの化学合成および構造と機能の探索Principal Investigator
- Principal Investigator
  
  和田猛
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
新規アンチセンス核酸を用いるエイズウイルス遺伝子の発現制御Principal Investigator
- Principal Investigator
  
  和田猛
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
官能基選択的ホスホリル化反応を用いる機能性核酸の分子構築Principal Investigator
- Principal Investigator
  
  和田猛
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Tokyo Institute of Technology
エイズウイルス遺伝子を標的とした新規アンチセンス核酸のマルチ固相合成Principal Investigator
- Principal Investigator
  
  和田猛
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Institute of Technology
アミノ基・リン酸基無保護法による新規アンチセンス核酸の分子構築Principal Investigator
- Principal Investigator
  
  和田猛
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Tokyo Institute of Technology
MOLECULAR DESIGN OF NEW EFFECTIVE ANTISENSE NUCLEIC ACIDS CAPABLE OF HYBRIDIZATION TO THE TARGET NENES
- Principal Investigator
  
  SEKINE Mitsuo
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  TOKYO INSTITUTE OF TECHNOLOGY
DEVELOPMENTS OF THE METHOD FOR THE CHEMICAL SYNTHESIS OF RNA CONTAINING MODIFIED BASED" -DIRECTED TOWARD FULL AUTOMATION OF RNA CONTAINING MODIFIED BASES BY USE OF NEW SYNTHETIC UNITS-
- Principal Investigator
  
  SEKINE Mitsuo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  広領域
- Research Institution
  TOKYO INSTITUTE OF TECHNOLOGY
超高速DNA/RNA化学合成法の開発-酵素反応にせまる効率的核酸合成反応-Principal Investigator
- Principal Investigator
  
  和田猛
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Tokyo Institute of Technology
環状ADPリボースの化学合成-イオン輸送のカギを握る新しい情報伝達分子-Principal Investigator
- Principal Investigator
  
  和田猛
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Tokyo Institute of Technology
CHEMICAL SYNTHESIS OF A NEW MATERIAL OF ANTISENSE NUCLEIC ACID "2'-PHOSPHORYLATED RNAS" -DIRECTED TOWARD ITS BASIC STRUCTURAL STUDIES AND REGULATION OF EXPRESSION OF HIV VIRUS-
- Principal Investigator
  
  SEKINE Mitsuo
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Molecular biology
- Research Institution
  TOKYO INSTITUTE OF TECHNOLOGY
CHEMICAL SYNTHESIS OF A NEW MATERIAL OF ANTISENSE NUCLEIC ACID"2"PHOSTHORYLATEDRNAS" DIRETED TOWARD IIS BASIC STRUCTRAL STUDIES AND REGULATION OF EXPRESSION OF HIV VIRUS-
- Principal Investigator
  
  SEKINE Mitsuo
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  天然物有機化学
- Research Institution
  TOKYO INSTITUTE OF TECHNOLOGY

[Book] 核酸医薬への有機合成化学的アプローチ2016
- Author(s)
  和田猛
- Total Pages
  278
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-15H03839
[Book] 複合糖質の化学と最新応用技術《普及版》2015
- Author(s)
  和田猛
- Total Pages
  298
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-15H03839
[Book] RNA工学の基礎と応用2011
- Author(s)
  和田猛, 他
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-21350088
[Book] フルオラスケミストリーの基礎と応用2010
- Author(s)
  和田猛(共著)
- Publisher
  CMC出版
- Data Source
  KAKENHI-PLANNED-21115008
[Book] 10. RNA工学の基礎と応用2010
- Author(s)
  和田猛(共著)
- Publisher
  CMC出版
- Data Source
  KAKENHI-PLANNED-21115008
[Book] 核酸医薬の最前線2009
- Author(s)
  和田猛(監修), 他
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-21350088
[Book] フルオラスケミストリー2007
- Author(s)
  和田猛(共著)
- Total Pages
  8
- Publisher
  シーエムシー出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Artificial cationic oligosaccharides for heteroduplex oligonucleotide-type drugs2018
- Author(s)
  Rintaro Iwata Hara, Yuki Hisada, Yusuke Maeda, Takanori Yokota, Takeshi Wada
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Pages: 4323-4323
- DOI
  10.1038/s41598-018-22161-8
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08933, KAKENHI-PROJECT-15K17886
[Journal Article] Solid-Phase Synthesis of Oligopeptides Containing Sterically Hindered Amino Acids on Nonswellable Resin Using 3-Nitro-1,2,4-triazol-1-yl-tris(pyrrolidin-1-yl)phosphonium Hexafluorophosphate (PyNTP) as the Condensing Reagent2018
- Author(s)
  Hara Rintaro Iwata、Mitsuhashi Yuta、Saito Keita、Maeda Yusuke、Wada Takeshi
- Journal Title
  
  ACS Combinatorial Science
  
  Volume: 20 Pages: 132-136
- DOI
  10.1021/acscombsci.7b00184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08933
[Journal Article] Stereocontrolled Synthesis of <i>P</i>-Modified <i>N</i>-Acetylmannosamine-α-1-phosphate Analogs2017
- Author(s)
  Hara Rintaro Iwata、Ogawa Yuki、Noro Mihoko、Wada Takeshi
- Journal Title
  
  Chemistry Letters
  
  Volume: 46 Issue: 7 Pages: 1051-1053
- DOI
  10.1246/cl.170349
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08933
[Journal Article] 薬として働く人工生体分子の合成2017
- Author(s)
  和田　猛
- Journal Title
  
  理大科学フォーラム
  
  Volume: 6 Pages: 26-27
- Data Source
  KAKENHI-PROJECT-17K08933
[Journal Article] Synthesis and properties of 2-deoxy-2-fluoromannosyl phosphate derivatives2017
- Author(s)
  Hara Rintaro Iwata、Kobayashi Satoshi、Noro Mihoko、Sato Kazuki、Wada Takeshi
- Journal Title
  
  Tetrahedron
  
  Volume: 73 Pages: 4560-4565
- DOI
  10.1016/j.tet.2017.06.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08933
[Journal Article] Synthesis of 2′-O-monohaloethoxymethyl-modified RNAs and their duplex formation ability2017
- Author(s)
  Hara Rintaro Iwata、Kageyama Masayuki、Arai Koichiro、Uchiyama Naoki、Wada Takeshi
- Journal Title
  
  RSC Advances
  
  Volume: 7 Pages: 41297-41303
- DOI
  10.1039/c7ra07767j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08933
[Journal Article] リン原子修飾オリゴ核酸の立体選択的合成2016
- Author(s)
  岡夏央、和田猛
- Journal Title
  
  有機合成化学協会誌
  
  Volume: 74 Pages: 31-44
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H03839
[Journal Article] 核酸医薬への化学的アプローチ2016
- Author(s)
  和田猛
- Journal Title
  
  MEDCHEM NEWS
  
  Volume: 26 Pages: 18-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H03839
[Journal Article] Enhancement of affinity of 2'-O-Me-oligonucleotides for complementary RNA by incorporating a stereoregulated boranophosphate backbone2015
- Author(s)
  Nukaga, Y.; Takemura, T.; Iwamoto, N.; Oka, N.; Wada, T.
- Journal Title
  
  RSC Advances
  
  Volume: 5 Pages: 2392-2395
- DOI
  10.1039/c4ra11335g
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26410175, KAKENHI-PUBLICLY-26105720, KAKENHI-PROJECT-15H03839
[Journal Article] Chimeric Antisense Oligonucleotide Conjugated to α-Tocopherol2015
- Author(s)
  Nishina T, Numata J, Nishina K, Yoshida-Tanaka K, Nitta K, Piao W, Iwata R, Ito S, Kuwahara H, Wada T, Mizusawa H, Yokota T
- Journal Title
  
  MOLECULAR THERAPY - NUCLEIC ACIDS
  
  Volume: 4
- DOI
  10.1038/mtna.2014.72
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26282136, KAKENHI-PROJECT-15H03839
[Journal Article] Synthesis and properties of vitamin E analog-conjugated neomycin for delivery of RNAi drugs to liver cells2015
- Author(s)
  Iwata R, Nakayama F, Hirochi S, Sato K, Piao W, Nishina K, Yokota T, Wada T
- Journal Title
  
  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  
  Volume: 25 Pages: 815-819
- DOI
  10.1016/j.bmcl.2014.12.079
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26282136, KAKENHI-PROJECT-15H03839
[Journal Article] Synthesis and properties of double-stranded RNA-bindable oligodiaminogalactose derivatives conjugated with vitamin E.2014
- Author(s)
  Rintaro Iwata, Kazutaka Nishina, Takanori Yokota, Takeshi Wada
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 22 Pages: 1394-1403
- DOI
  10.1016/j.bmc.2013.12.060
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008, KAKENHI-PROJECT-25000006, KAKENHI-PROJECT-26282136
[Journal Article] 3-Nitro-l,2,4-triazol-l-yl-tris(pyrrolidin-1-yl)phosphonium hexafluorophosphate (PyNTP) as a condensing reagent for solid-phase peptide synthesis2014
- Author(s)
  Keita Saito, Takeshi Wada
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 55 Pages: 1991-1993
- DOI
  10.1016/j.tetlet.2014.02.013
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Solid-phase synthesis of P-boronated oligonucleotides by the H-boranophosphonate method2014
- Author(s)
  Sho Uehara, Shingo Hiura, Renpei Higashida, Natsuhisa Oka, Takeshi Wada
- Journal Title
  
  J. Org. Chem
  
  Volume: 79 Pages: 3465-3472
- DOI
  10.1021/jo500185b
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008, KAKENHI-PUBLICLY-24105510, KAKENHI-PROJECT-24790108
[Journal Article] Synthesis and properties of double-stranded RNA-bindable oligodiaminogalactose derivatives conju-gated with vitamin E2014
- Author(s)
  Iwata R, Nishina K, Yokota, T, Wada T
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 22(4) Pages: 1394-1403
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Solid-phase synthesis of p-boronated oligonucleotides by the H-boranophosphonate method2014
- Author(s)
  Uehara S, Hiura S, Higashida R, Oka N, Wada T
- Journal Title
  
  J. Org. Chem.
  
  Volume: 79(8) Pages: 3465-72
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Stereoselective synthesis of P-modified α-glycosyl phosphates by the oxazaphospholidine approach2013
- Author(s)
  Noro M, Fujita S, Wada T
- Journal Title
  
  Org. Lett.
  
  Volume: 15(23) Pages: 5948-51
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] A protein-protein interaction assay based on the functional complementation of mutant firefly luciferases2013
- Author(s)
  Yuki Ohmuro-Matsuyama, Kota Nakano, Aoi Kimura, Keiichi Ayabe and Hiroshi Ueda
- Journal Title
  
  Anal. Chem.
  
  Volume: 85 Pages: 7935-7940
- DOI
  10.1021/ac4016825
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J40072, KAKENHI-PLANNED-21115008, KAKENHI-PROJECT-24360336
[Journal Article] Stereocontrolled synthesis of dinucleoside phosphorothioates using a fluorous tag2013
- Author(s)
  Oka N, Murakami R, Kondo T, Wada T
- Journal Title
  
  J. Fluor. Chem.
  
  Volume: 150 Pages: 85-91
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Stereoselective Synthesis of P-Modified α-Glycosyl Phosphates by the Oxazaphospholidine Approach2013
- Author(s)
  Mihoko Noro, Shoichi Fujita, Takeshi Wada
- Journal Title
  
  Org. Lett.
  
  Volume: 15 Pages: 5948-5951
- DOI
  10.1021/ol402785h
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] 34. Glycosylation of alcohols using glycosyl boranophosphates as glycosyl donors2013
- Author(s)
  Natsuhisa Oka, Shiro Tatsumi, Fumiko Matsumura, Takeshi Wada
- Journal Title
  
  Tetrahedron Lett
  
  Volume: 54 Pages: 3731-3734
- DOI
  10.1016/j.tetlet.2013.04.032
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008, KAKENHI-PUBLICLY-24105510, KAKENHI-PROJECT-24790108
[Journal Article] Synthesis and properties of cationic oligopeptides with different side chain lengths that bind to RNA duplexes2013
- Author(s)
  Maeda Y, Iwata R, Wada T
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 21(7) Pages: 1717-23
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] 核酸医薬品に求められるもの2012
- Author(s)
  和田猛
- Journal Title
  
  医薬ジャーナル
  
  Volume: 48 Pages: 61-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] Synthesis of nucleoside 5'-boranophosphorothioate derivatives using an H-boranophosphonate monoester as a precursor2012
- Author(s)
  Oka N, Takayama Y, Ando K, Wada T
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 22(14) Pages: 4571-4
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Stereocontrolled solid-phase synthesis of phosphorothioate oligoribonucleotides using 2'-O-(2-cyanoethoxymethyl)-nucleoside 3'-O-oxazaphospholidine monomers2012
- Author(s)
  Nukaga Y, Yamada K, Ogata T, Oka N, Wada T
- Journal Title
  
  J. Org. Chem.
  
  Volume: 77(18) Pages: 7913-22
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] リン原子修飾核酸の合成と医薬への応用2012
- Author(s)
  和田猛
- Journal Title
  
  医薬ジャーナル
  
  Volume: 48 Pages: 71-76
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Stereocontrolled Solid- Phase Synthesis of Phosphorothioate Oligoribonucleotides Using 2'-O-(2- Cyanoethoxymethyl)-Nucleoside 3'-O- Oxazaphospholi- dine Monomers2012
- Author(s)
  Nukaga, Y., Yamada, K., Ogata, T., Oka, N., Wada, T.
- Journal Title
  
  J. Org. Chem.
  
  Volume: 77 Pages: 7913-7922
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] 核酸医薬品に求められるもの2012
- Author(s)
  和田猛
- Journal Title
  
  医薬ジャーナル
  
  Volume: 48 Pages: 61-63
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] リン原子修飾核酸の合成と医薬への応用2012
- Author(s)
  和田猛
- Journal Title
  
  医薬ジャーナル
  
  Volume: 48 Pages: 71-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] Stereo-controlled synthesis of oligodeoxyribonucleoside boranophosphates by an oxazaphospholidine approach using acid-labile N-protecting groups2012
- Author(s)
  Iwamoto N, Oka N, Wada T
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 53(33) Pages: 4361-4364
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Synthesis and properties of novel 2'-O-alkoxymethyl-modified nucleic acids2011
- Author(s)
  Arai, K., Uchiyama, N., Wada, T.
- Journal Title
  
  Bioorg.Med.Chem.Lett.
  
  Volume: 21 Pages: 6285-6287
- DOI
  10.1016/j.bmcl.2011.09.003
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008, KAKENHI-PROJECT-21350088
[Journal Article] Stereocontrolled synthesis of oligonucleotide analogs containing chiral in ternucleotidic phosphorus atoms2011
- Author(s)
  Oka, N., Wada, T.
- Journal Title
  
  Chem.Soc.Rev.
  
  Volume: 40 Pages: 5829-5843
- DOI
  10.1039/c1cs15102a
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008, KAKENHI-PROJECT-21350088
[Journal Article] Synthesis of Oligodiaminosaccharides Having a α-Glycoside Bonds and Their Interactions with Oligonucleotide Duplexes2011
- Author(s)
  Rintaro Iwata, Masafumi Sudo, Kenta Nagafuji, Takeshi Wada
- Journal Title
  
  J.Org.Chem.
  
  Volume: 76 Pages: 5895-5906
- DOI
  10.1021/jo200951p
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J05612, KAKENHI-PLANNED-21115008, KAKENHI-PROJECT-21350088
[Journal Article] Stereocontrolled synthesis of oligonucleotide analogs containing chiral internucleotidic phosphorus atoms2011
- Author(s)
  Oka N, Wada T
- Journal Title
  
  Chem. Soc. Rev.
  
  Volume: 40(12) Pages: 5829-43
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Stereocontrolled synthesis of oligonucleotide analogs containing chiral internucleotidic phosphorus atoms2011
- Author(s)
  Oka, N., Wada, T.
- Journal Title
  
  Chem. Soc. Rev.
  
  Volume: 40 Pages: 5829-5843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] Synthesis and properties of novel 2'-O-alkoxymethylmodified nucleic acids2011
- Author(s)
  Arai K, Uchiyama N, Wada T
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 21(21) Pages: 6285-7
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Solid-phase synthesis of oligodeoxyribonucleotides without base protection utilizing O-selective reaction of oxazaphospholidine derivatives2010
- Author(s)
  Oka, N., Maizuru, Y., Shimizu, M., Wada, T.
- Journal Title
  
  Nucleos.Nucleot.Nucl.Acids
  
  Volume: 29 Pages: 144-154
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] 1,2-trans-selective synthesis of Glycosyl Boranophosphates and their utility as building blocks for the synthesis of phosphodiester-linked disaccharides2010
- Author(s)
  Sato, K., Oka, N., Fujita, S., Matsu mura, F., Wada, T.
- Journal Title
  
  J.Org.Chem.
  
  Volume: 75 Pages: 2147-2156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] Solid-phase synthesis of oligodeoxyribonucleotides without base protection utilizing O-selective reaction of oxazaphospholidine derivatives2010
- Author(s)
  Oka N, Maizuru Y, Shimizu M, Wada T
- Journal Title
  
  Nucleos Nucleot Nucl Acids.
  
  Volume: 29 Pages: 144-145
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Synthesis and biological activity of artificial mRNA prepared with novel phosphorylating reagents2010
- Author(s)
  Nagata, S., Hamasaki, T., Uetake, K Masuda, H., Takagaki, K., Oka, N Wada.T., Ohgi, T., Yano, J.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 38 Pages: 7845-7857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] Synthesis, gene-silencing activity and nuclease resistance of 3'-3'-linked double short hairpin RNA2010
- Author(s)
  Masuda, H., Watanabe, N., Naruoka, H., Nagata, S., Takagaki K., Wada, T., Yano J.
- Journal Title
  
  Bioorg Med.Chem.
  
  Volume: 18 Pages: 8277-8283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] Synthesis, gene-silencing activity and nuclease resistance of 3'-3'-linked double short hairpin RNA2010
- Author(s)
  Masuda, H., Watanabe, N., Naruoka, H., Nagata, S., Takagaki K., Wada, T., Yano J.
- Journal Title
  
  Bioorg Med.Chem.
  
  Volume: 18 Pages: 8277-8283
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Synthesis and biological activity of artificial mRNA prepared with novel phosphorylating reagents2010
- Author(s)
  Nagata, S., Hamasaki, T., Uetake, K., Masuda, H., Takagaki, K., Oka, N., Wada, T., Ohgi, T., Yano, J.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 38 Pages: 7845-7857
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Agmatine-conjugated cytidine in a tRNA anticodon is essential for AUA decoding in archaea2010
- Author(s)
  Ikeuchi, Y., Kimura, S., Numata, T., Nakamura, D., Yokogawa, T., Ogata T., Wada, T., Suzuki, T., Suzuki, T.
- Journal Title
  
  Nat.Chem.Biol.
  
  Volume: 6 Pages: 277-282
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] Agmatine-conjugated cytidine in a tRNA anticodon is essential for AUA decoding in archaea2010
- Author(s)
  Ikeuchi Y, Kimura S, Numata T, Nakamura D, Yokogawa T, Ogata T, Wada T, Suzuki T, Suzuki T
- Journal Title
  
  Nat Chem Biol
  
  Volume: 6(4) Pages: 277-282
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-21115001
[Journal Article] Solid-phase synthesis of oligodeoxyribonucleotides without base protection utilizing O-selective reaction of oxazaphospholidine derivatives2010
- Author(s)
  Oka, N., Maizuru, Y., Shimizu, M., Wada, T.
- Journal Title
  
  Nucleos.Nucleot.Nucl.Acids
  
  Volume: 29 Pages: 144-154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] Agmatine-conjugated cytidine in a tRNA anticodon is essential for AUA decoding in archaea2010
- Author(s)
  Ikeuchi, Y., Kimura, S., Numata, T., Nakamura, D., Yokogawa, T., Ogata, T., Wada, T., Suzuki, T., Suzuki, T.
- Journal Title
  
  Nat.Chem.Biol.
  
  Volume: 6 Pages: 277-282
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Rapid glycosylation under extremely mild acidic conditions.Use of ammonium salts to activate glycosyl phosphites via P-protonation2010
- Author(s)
  Matsumura, F., Tatsumi, S., Oka, N., Wada, T.
- Journal Title
  
  Carbohyd.Res.
  
  Volume: 345 Pages: 1211-1215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] Nucleoside H-Boranophosphonates : a New Class of Boron-Containing Nucleotide Analogues2009
- Author(s)
  Higashida, R., Oka, N., Kawanaka, T., Wada, T.
- Journal Title
  
  Chem.Commun.
  
  Pages: 2466-2468
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Stereocontrolled synthesis of oligodeoxyribonucleoside boranophosphates via stereodefined H-phosphonate intermediate2009
- Author(s)
  Iwamoto, N., Oka, N., Wada, T.
- Journal Title
  
  Nucleic Acids Symp. Ser. 53
  
  Pages: 9-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] Stereocontrolled Solid-phase Synthesis of Oligonucleoside H-phosphonates by an Oxazaphospholidine Approach2009
- Author(s)
  Iwamoto, N., Oka, N., Sato, T., Wada, T.
- Journal Title
  
  Angew.Chem.Int.Ed. 48
  
  Pages: 496-499
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] Stereo-controlled synthesis of oligodeoxyribonucleoside boranophosphates via stereodefined H-phosphonate intermediates2009
- Author(s)
  Iwamoto N, Oka N, Wada T
- Journal Title
  
  Nucleic Acids Symp Ser.
  
  Volume: (53) Pages: 9-10
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Chemical synthesis of nucleoside H-boranophopsphonates and their application as precursors of P-modified nucleotide analogue2009
- Author(s)
  Oka, N., Higashida, R., Takayama, Y., Ando, K., Wada, T.
- Journal Title
  
  Nucleic Acids Symp.Ser. 53
  
  Pages: 111-112
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Chemical Synthesis and Properties of 5-Taurinomethyluridine and 5-Taurinomethyl-2-thiouridine2009
- Author(s)
  Ogata, T., Shimazaki, T., Umemoto, T., Kurata, S., Ohtsuki, T., Suzuki, T., Wada, T.
- Journal Title
  
  J.Org. Chem. 74
  
  Pages: 2585-2588
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] Chemical synthesis of nucleoside H-boranophosphonates and their application as precursors of P-modified nucleotide analogues2009
- Author(s)
  Oka N, Higashida R, Takayama Y, Ando K, Wada T
- Journal Title
  
  Nucleic Acids Symp Ser.
  
  Volume: (53) Pages: 111-2
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Stereocontrolled Synthesis of Oligoribonucleoside Phosphorothioates by an Oxazaphospholidine Approach2009
- Author(s)
  Oka, N., Kondo, T., Fujiwara, S., Maizuru, Y., Wada, T.
- Journal Title
  
  Org.Lett. 11
  
  Pages: 967-970
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Solid-phase synthesis of backbone-modefied DNA analogs by the boranophosphotriester method using new protecting groups for nucleobases2008
- Author(s)
  Kawanaka, T., Shimizu, M., Shintani, N, Wada, T.
- Journal Title
  
  Bioorg. Med. Chem. Lett. 13
  
  Pages: 783-3786
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Synthesis of glycosyl boranophosphates and their applications as precursors of glycosyl phosphate analogues2008
- Author(s)
  Matsumura, F.; Oka, N; Wada, T.
- Journal Title
  
  Organic Letters 10
  
  Pages: 1557-1560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Synthesis of Dinucleoside Phosphates and their Analogs by the Boranophosphotriester Method Using Azido-Based Protecting Groups2007
- Author(s)
  Kawanaka, T., Shintani, N., Shimizu, M, Wada, T.
- Journal Title
  
  Tetrahedron Lett. 48
  
  Pages: 1973-1976
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Solid-phase synthesis and propenies of chiral peptide nucleic acids bearing cationic side chains2007
- Author(s)
  Harada, H.; Funayama, S., Shoji, Y; Wada, T.
- Journal Title
  
  Nueleic Acids Symp.Ser 51
  
  Pages: 259-260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Chemical synthesis and properties of stereoregulated phosphorothioate RNAs2007
- Author(s)
  Wada. T., Kondo, T., Fujiwara, S., Sato, T., Oka, N.
- Journal Title
  
  □Nucleic Acids Symp. Ser. 51
  
  Pages: 119-120
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Synthesis of dinucleoside phosphates and their analogs by the boranophosphotriester method using azido-based protecting groups2007
- Author(s)
  Kawanaka, T.; Shintani, N.; Shimizu, M.; Wada, T.
- Journal Title
  
  Tetrahedron Letters 48
  
  Pages: 1973-1976
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Nucleoside H-boranophosphonates : Synthesis and properties of a new class of nucleotide analogs2007
- Author(s)
  Higashida, R., Kawanaka, T., Oka, N., Wada. T.
- Journal Title
  
  Nucleic Acids Symp. Ser. 51
  
  Pages: 133-134
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Chemical synthesis and properties of stereoregulated phosphorothioate RNAs2007
- Author(s)
  Wada, T.; Kondo, T.; Fujiwara, S.; Sato, T.; Oka, N.
- Journal Title
  
  Nucleic Acids Symp.Ser 51
  
  Pages: 119-120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Nucleoside H-boranophosphonates:Synthesis and properties of a new class of nucleotide analogs2007
- Author(s)
  Higashida, R.; Kawanaka, T.; Oka, N.; Wada, T.
- Journal Title
  
  Nucleic Acids Symp.Ser 51
  
  Pages: 133-134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Protein-based peptide-bond formation by aminoacyl-tRNA protein transferase2007
- Author(s)
  Watanabe, K., Toh, Y., Suto, K., Shimizu, Y., Oka, N., Wada. T., Tomita, K.
- Journal Title
  
  Nature 449
  
  Pages: 867-871
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Protein-based peptide-bond formation by aminoacyl-tRNA protein transfcrase2007
- Author(s)
  Watanabe, K.; Toh, Y.; Suto, K.; Shimizu, Y.; Oka, N.; Wada, T.; Tomita, K.
- Journal Title
  
  Nature 449
  
  Pages: 867-871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Solid-phase synthesis and properties of chiral peptide nucleic acids bearing cationic side chains2007
- Author(s)
  Harada, H., Funayama, S., Shoji, Y, Wada. T.
- Journal Title
  
  Nucleic Acids Symp. Ser. 51
  
  Pages: 259-260
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Synthesis of a Novel Ester Analog of Nucleic Acids Bearing a Serine Backbone2006
- Author(s)
  Murata, A., Wada, T.
- Journal Title
  
  Bioorg. Med. Chem. Lett. 16
  
  Pages: 2933-2936
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] 1,3-Dimethyl-2-(3-nitoro-1, 2, 4-triazol-1-yl)-2-pyrrolidin-1-yl-1, 3, 2-diazaphospholidinium Hexafluorophosphate : a Powerful Condensing Reagent for Phosphate and Phosphonate Esters2006
- Author(s)
  Oka, N., Shimizu, M., Saigo, K., Wada, T.
- Journal Title
  
  Tetrahedron 62
  
  Pages: 3667-3673
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Highly Chemo- and Regioselective Phosphitylation of Unprotected 2'-Deoxyribonucleosides2006
- Author(s)
  Kato, Y., Oka, N., Wada, T.
- Journal Title
  
  Tetrahedron Lett. 47
  
  Pages: 2501-2505
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] A Novel Linker for Solid-phase Synthesis Cleavable under Neutral Conditions2006
- Author(s)
  Murata, A., Wada, T.
- Journal Title
  
  Tetrahedron Lett. 47
  
  Pages: 2147-2150
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Stereoselective Synthesis of Dinucleoside Boranophosphates by an Oxazaphospholidine Method2006
- Author(s)
  Wada, T., Maizuru, Y., Oka, N., Saigo, K.
- Journal Title
  
  Bioorg. Med. Chem. Lett. 16
  
  Pages: 3111-3114
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Solid-phase Synthesis of Oligodeoxyribonucleoside Boranophosphates by the Boranophosphotriester Method2006
- Author(s)
  Shimizu, M., Saigo, K., Wada, T.
- Journal Title
  
  J. Org. Chem. 71
  
  Pages: 4262-4269
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Nitromethane as a Scavenger of Acrylonitrile in the Deprotection of Synthetic Oligonucleotides2005
- Author(s)
  Umemoto, T., Wada, T.
- Journal Title
  
  Tetrahedron Lett. 46
  
  Pages: 4251-4253
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Stereocontrolled Synthesis of Phosphorothioate DNA by the Oxazaphospholidine Approach2005
- Author(s)
  Wada, T.
- Journal Title
  
  Front Org.Chem. 1・1
  
  Pages: 41-61
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] A Novel Method for the Synthesis of DNA Using 2'-Deoxyribonucleoside 5'-Phosphites as Monomer Units2005
- Author(s)
  Kato, Y., Saigo, K., Wada, T.
- Journal Title
  
  Nucleic Acids Symp.Ser. 49
  
  Pages: 129-130
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Stereocontrolled synthesis of phosphorothioate DNA by the oxazaphospholidine approach.2005
- Author(s)
  Wada, T.
- Journal Title
  
  Front. Org. Chem. 1
  
  Pages: 41-61
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] Stereocontrolled Synthesis of Dinucleoside Boranophosphates by an Oxazaphospholidine Method2005
- Author(s)
  Oka, N., Maizuru, Y., Shimizu, M., Saigo, K., Wada, T.
- Journal Title
  
  Nucleic Acids Symp.Ser. 49
  
  Pages: 131-132
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] A Novel Method for the Synthesis of DNA and its Analogs by the Use of BH_3 as protecting Group for Phosphonic Acid2005
- Author(s)
  Kawanaka, T., Shimizu, M., Saigo, K., Wada, T.
- Journal Title
  
  Nucleic Acids Symp.Ser. 49
  
  Pages: 27-28
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Highly Chemo- and Regioselective Phosphitylation of Unprotected 2'-Deoxyribonucleosides2005
- Author(s)
  Kato, Y., Oka, N., Wada, T.
- Journal Title
  
  Tetrahedron Lett. 47(in press)
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Stereocontrolled Synthesis of Phosphorothioate DNA by the Oxazaphospholidine Approach2005
- Author(s)
  Wada, T.
- Journal Title
  
  Front.Org.Chem. 1・1
  
  Pages: 41-61
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] BH_3 as a Protecting Group for Phosphonic Acids : A Novel Method for the Synthesis of Dinucleoside H-Phosphonates2004
- Author(s)
  Shimizu, M., Tamura, K., Wada, T., Saigo, K.
- Journal Title
  
  Tetrahedron Lett. 45
  
  Pages: 371-374
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] Oligoribonucleotide Synthesis by the Use of 1-(2-Cyanoethoxy)ethyl (CEE) As a 2'-Hydroxy Protecting Group2004
- Author(s)
  Umemoto, t., Wada, T.
- Journal Title
  
  Tetrahedron Lett. 45
  
  Pages: 9529-9531
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] A Novel Method for the Synthesis of Dinucleoside Boranophosphates by a Boranophosohotriester Method2004
- Author(s)
  Shimizu, M., Wada, T., Oka, N., Saigo, K.
- Journal Title
  
  J.Org.Chem. 69・16
  
  Pages: 5261-5268
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] A Novel Method for the Synthesis of Dinucleoside Boranophosphates by a Boranophosohotriester Method2004
- Author(s)
  Shimizu, M., Wada, T., Oka, N., Saigo, K.
- Journal Title
  
  J.Org.Chem. 69・16
  
  Pages: 5261-5268
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] RNA Interference (RNAi) and Chemical Synthesis of RNA2004
- Author(s)
  Wada, T.
- Journal Title
  
  Bio Industry 21
  
  Pages: 17-24
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] Stereocontrolled Synthesis of Phosphorothioate RNA by the Oxazaphospholi-dine Approach2004
- Author(s)
  Wada.T., Fujiwara, S., Sato, T., Oka, N., Saigo, K.
- Journal Title
  
  Nucleic Acids Symp.Ser. 47
  
  Pages: 57-58
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] BH_3 as a Protecting Group for Phosphonic Acids : A Novel Method for the Synthesis of Dinucleoside H-Phosphonates2004
- Author(s)
  Shimizu, M., Tamura, K., Wada, T., Saigo, K.
- Journal Title
  
  Tetrahedron Lett. 45
  
  Pages: 371-374
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Oligoribonucleotide Synthesis by the Use of 1-(2-Cyanoethoxy)ethyl (CEE) As a 2'-Hydroxy Protecting Group2004
- Author(s)
  Umemoto, T., Wada, T.
- Journal Title
  
  Tetrahedron Lett. 45
  
  Pages: 9529-9531
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] Stereocontrolled Synthesis of Phosphorothioate RNA by the Oxazaphospholidine Approach2004
- Author(s)
  Wada, T., Fujiwara, S., Sato, T., Oka, N., Saigo, K.
- Journal Title
  
  Nucleic Acids Symp.Ser. 47
  
  Pages: 57-58
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] RNA Interference (RNAi) and Chemical Synthesis of RNA2004
- Author(s)
  Wada, T.
- Journal Title
  
  Bio Industry 21
  
  Pages: 17-24
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Synthesis of Dinucleoside Boranophosphates by a Boranophosphotriester Approach2003
- Author(s)
  Wada, T., et al.
- Journal Title
  
  Nucleosides, Nucleotides, Nucleic Acids 22
  
  Pages: 1431-1433
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] Synthesis of Chiral Oligopeptides which Recognize Double-stranded DNAs2003
- Author(s)
  Wada.T., Funayama, S., Shoji, Y., Saigo, K.
- Journal Title
  
  Peptide Science 40
  
  Pages: 181-182
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] Solid-phase Synthesis of a Novel Polyester Analog of Nucleic Acid Bearing Serine Backbone2003
- Author(s)
  Wada, T., Murata, A., Tsuneyama, T., Saigo, K.
- Journal Title
  
  Peptide Science 40
  
  Pages: 159-150
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] Synthesis of Dinucleoside Boranophosphates by a Boranophosphotriester Approach2003
- Author(s)
  Wada.T., Shimizu, M., Oka, N., Saigo, K.
- Journal Title
  
  Nucleosides, Nucleotides, Nucleic Acids 22
  
  Pages: 1431-1433
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] Synthesis of Dinucleoside Boranophosphates by a Boranophosphotriester2003
- Author(s)
  Wada, T., Shimizu, M., Oka, N., Saigo, K.
- Journal Title
  
  Nucleosides, Nucleotides, Nucleic Acids 22
  
  Pages: 1471-1473
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] Solid-phase Synthesis of a Novel Polyester analog of Nucleic Acid Bearing Serine Backbone2003
- Author(s)
  Wada, T., Murata, A., Tsuneyama, T., Saigo, K.
- Journal Title
  
  Peptide Science 40
  
  Pages: 159-160
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] Diastereocontrolled Synthesis of Phosphorothioate DNA via an Oxazaphospholidine Approach Using a Novel Class of Activators, Dialkyl(cyanomethyl)-ammonium salts2003
- Author(s)
  Oka, N, Wada, T., Saigo, K.
- Journal Title
  
  Nucleosides, Nucleotides, Nucleic Acids 22
  
  Pages: 1411-1413
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] An Oxazaphospholidine Approach for the Stereocontrolled Synthesis of Oligonucleoside Phosphorothioates2003
- Author(s)
  Oka, N, Wada.T., Saigo, K.
- Journal Title
  
  J.Am.Chem.Soc. 125
  
  Pages: 8307-8317
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] Synthesis of Chiral Oligopeptides which Recognize Double-stranded DNAs2003
- Author(s)
  Wada, T. et al.
- Journal Title
  
  Peptide Science 40
  
  Pages: 181-182
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] Solid-phase Synthesis of a Novel Polyester Analog of Nucleic Acid Bearing Serine Backbone2003
- Author(s)
  Wada, T. et al.
- Journal Title
  
  Peptide Science 40
  
  Pages: 159-150
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] An Oxazaphospholidine Approach for the Stereocontrolled Synthesis of Ologonucleoside Phosphorothioates2003
- Author(s)
  Oka, N., Wada, T., Saigo, K.
- Journal Title
  
  J. Am. Chem. Soc. 125
  
  Pages: 8307-8317
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] Reaction Mechanism for the Sterercontrolled Synthesis of Phosphorothioate DNA by the Oxazaphospholidine Approach2003
- Author(s)
  Wada.T., Oka, N, Saigo, K.
- Journal Title
  
  Nucleosides, Nucleotides, Nucleic Acids 22
  
  Pages: 1471-1473
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] Reaction Mechanism for the Sterercontrolled Synthesis of Phosphorothioate DNA by the Oxazaphospholidine Approach2003
- Author(s)
  Wada, T., Oka, N, Saigo, K.
- Journal Title
  
  Nucleosides, Nucleotides, Nucleic Acids 22
  
  Pages: 1431-1433
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] Diastereocontrolled Synthesis of Phosphorothioate DNA via an Oxazaphospholidine Approach Using a Novel Class of Activators, Dialkyl(cyanomethyl)ammonium salts2003
- Author(s)
  Oka, N, Wada, T., Saigo, K.
- Journal Title
  
  Nucleosides, Nucleotides, Nucleic Acids 22
  
  Pages: 1141-1143
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] Reaction Mechanism for the Sterercontrolled Synthesis of Phosphorothio- ate DNA by the Oxazaphospholidine Approach2003
- Author(s)
  Wada, T. et al.
- Journal Title
  
  Nucleosides, Nucleotides, Nucleic Acids 222
  
  Pages: 1471-1473
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] Synthesis of Chiral Oligopeptides which Recognize Double-stranded DNAs2003
- Author(s)
  Wada, T., Funayama, S., Shoji, Y., Saigo, K.
- Journal Title
  
  Peptids Science 40
  
  Pages: 181-182
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] A New Boranophosphorylation Reaction for the Synthesis of Deoxyribonucleoside Boranophosphates2002
- Author(s)
  Wada, T.et al.
- Journal Title
  
  Tetrahedron Lett. 43
  
  Pages: 4137-4140
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] Taurine as a Constituent of Mitochondrial tRNAs : New Insight into the Functions of Taurine and Human Mitochondrial Diseases2002
- Author(s)
  Suzuki, T., Suzuki, T., Wada.T., Saigo, K., Watanabe, K.
- Journal Title
  
  EMBO J. 21
  
  Pages: 6581-6589
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] Diastereocontrolled Synthesis of Dinucleoside Phosphorothioates Using a Novel Activators, Dialkyl(cyanomethyl)ammonium Tetrafluoroborates2002
- Author(s)
  Oka, N, Wada.T., Saigo, K.
- Journal Title
  
  J.Am.Chem.Soc. 124
  
  Pages: 1962-1963
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] A New Boranophosphorylation Reaction for the Synthesis of Deoxyribo- nucleoside Boranophosphates2002
- Author(s)
  Wada, T. et al.
- Journal Title
  
  Tetrahedron Lett. 43
  
  Pages: 4137-4140
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] A New Boranophosphorylation Reaction for the Synthesis of Deoxyribonucleoside Boranophosphates2002
- Author(s)
  Wada.T., Shimizu, M., Oka, N., Saigo, K.
- Journal Title
  
  Tetrahedron Lett. 43
  
  Pages: 4137-4140
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Presentation] 化学構造式から見たアカデミック・ディテーリング2018
- Author(s)
  和田猛
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08933
[Presentation] Stereocontrolled synthesis and properties of boranophosphate DNA2017
- Author(s)
  和田　猛
- Organizer
  FISNA2017
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-17K08933
[Presentation] 核酸医薬の安定化と高活性化へ向けた分子技術の開発2017
- Author(s)
  和田　猛
- Organizer
  BioJapan2017
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-17K08933
[Presentation] Stabilization and Activation of Double-stranded Nucleic Acid Drugs by Artificial Cationic Molecules2016
- Author(s)
  Takeshi Wada
- Organizer
  AsiaTIDES 2016
- Place of Presentation
  ウェスティン都ホテル京都（京都府京都市）
- Year and Date
  2016-02-24
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] 核酸医薬の安定化と高活性化へ向けた分子技術の創製2015
- Author(s)
  和田猛
- Organizer
  日本核酸医薬学会第1回年会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2015-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] New Synthetic Approaches to Oligonucleotide Therapeutics2015
- Author(s)
  Takeshi Wada
- Organizer
  Asian 3 Roundtable on Nucleic Acids 2015
- Place of Presentation
  スウォン（韓国）
- Year and Date
  2015-09-18
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] 核酸医薬への有機合成化学的アプローチ2015
- Author(s)
  和田猛
- Organizer
  第52回薬剤学懇談会研究討論会
- Place of Presentation
  瑠璃光（石川県加賀市）
- Year and Date
  2015-07-16
- Invited
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] Stereocontrolled synthesis of boron-containing oligonucleotides as therapeutic agents2015
- Author(s)
  Takeshi Wada
- Organizer
  Pacifichem2015
- Place of Presentation
  ホノルル（アメリカ合衆国）
- Year and Date
  2015-12-15
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] 核酸医薬への合成化学的アプローチ2014
- Author(s)
  和田猛
- Organizer
  第25回歯工学連携講演会
- Place of Presentation
  九州工業大学、北九州
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] リン原子修飾核酸医薬の立体制御2013
- Author(s)
  和田猛
- Organizer
  Symposium on Innovative Research at KUT Part 1
- Place of Presentation
  高知工科大学、高知
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] リン原子修飾核酸医薬の立体制御、次世代医薬「核酸医薬」創出に向けた Strategy2013
- Author(s)
  和田猛
- Organizer
  次世代医薬「核酸医薬」創出に向けた Strategy
- Place of Presentation
  コクヨホール、東京
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] 有機合成で創り出す核酸医薬への新しいアプローチ2013
- Author(s)
  和田猛
- Organizer
  第23回万有福岡シンポジウム
- Place of Presentation
  九州大学、福岡
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] New synthetic strategies for RNA drugs2013
- Author(s)
  和田猛
- Organizer
  第15回RNAミーティング
- Place of Presentation
  愛媛県・県民文化会館、愛媛
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] Synthesis and Properties of 2´-O-Haloethox- ymethyl RNA2012
- Author(s)
  和田猛
- Organizer
  第39回国際核酸化学シンポジウム
- Place of Presentation
  名古屋大学（名古屋）
- Year and Date
  2012-11-15
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] 医薬品を志向した機能性キラル核酸の創成2012
- Author(s)
  和田猛
- Organizer
  第40回バイオインターフェース
- Place of Presentation
  全理連ビル、東京
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] Stereocontrolled synthesis and properties of P-chiral oligonucleotides2012
- Author(s)
  和田猛
- Organizer
  8th Annual Meeting of the Oligonucleotide Therapeutics Society 2012
- Place of Presentation
  ハーバード大学、アメリカ
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] 薬として働く核酸分子を化学の力で組み立てる2012
- Author(s)
  和田猛
- Organizer
  第7回理研「バイオものづくり」シンポジウム
- Place of Presentation
  理化学研究所和光キャンパス、和光市
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] リン原子修飾核酸医薬の化学的創製2011
- Author(s)
  和田猛
- Organizer
  第8回分子複合医薬研究会
- Place of Presentation
  産業技術総合研究所関西センター、大阪
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] 2'-O-CEM基を用いるオキサザホスホリジン法によるホスホロチオェートRNAの立体選択的合成2011
- Author(s)
  額賀陽平, 山田浩平, 緒方俊彦, 和田猛
- Organizer
  日本化学会第92春季年会
- Place of Presentation
  神奈川大学横浜キャンパス
- Year and Date
  2011-03-26
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] リン原子修飾核酸医薬の化学的創製2011
- Author(s)
  和田猛
- Organizer
  第27回日本DDS学会
- Place of Presentation
  東京大学、東京
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] 2'-O-CEM基を用いるオキサザホスホリジン法によるホスホロチオエートRNAの立体選択的合成2011
- Author(s)
  額賀陽平, 山田浩平, 緒方俊彦, 和田猛
- Organizer
  日本化学会第92春季年会
- Place of Presentation
  神奈川大学横浜キャンパス
- Year and Date
  2011-03-26
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] リン原子修飾核酸医薬の化学的創製2011
- Author(s)
  和田猛
- Organizer
  第8回分子複合医薬研究会
- Place of Presentation
  産業技術総合研究所関西センター
- Year and Date
  2011-12-09
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] P-Chiral Nucleic Acids as New Therapeutic Agents2011
- Author(s)
  和田猛
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜、横浜
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] P-Chiral Nucleic Acids as New Therapeutic Agents2011
- Author(s)
  和田猛
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] 核酸医薬の新機軸2011
- Author(s)
  和田猛
- Organizer
  第38回BMBコンファレンス
- Place of Presentation
  箱根高原ホテル
- Year and Date
  2011-07-10
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] 核酸医薬の新機軸2011
- Author(s)
  和田猛
- Organizer
  第38回BMBコンファレンス
- Place of Presentation
  箱根高原ホテル、神奈川
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] リン原子修飾核酸医薬の化学的創製2011
- Author(s)
  和田猛
- Organizer
  第27回日本DDS学会
- Place of Presentation
  東京大学
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] Stereocontrolled synthesis of P-chiral nucleic acid analogs as therapeutic agents2010
- Author(s)
  Wada, T.
- Organizer
  Asian 3 Roundtable on Nucleic Acids
- Place of Presentation
  関西国際空港会議場
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] New aspects for the chemical synthesis of backbone-modified nucleic acids as therapeutic agents2010
- Author(s)
  Wada, T.
- Organizer
  2010 The International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  ハワイコンベンションセンター(ホノルル、アメリカ)
- Year and Date
  2010-12-15
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] H-ボラノホスホネートDNA類縁体の合成と変換反応2010
- Author(s)
  植原渉, 日浦進吾, 東田廉平, 岡夏央, 和田猛
- Organizer
  第20回アンチセンスシンポジウム
- Place of Presentation
  甲南大学
- Year and Date
  2010-12-02
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] β,γ-ジアミノ酸骨格を有する新規ペプチド核酸の合成2010
- Author(s)
  斉藤敬太, 堀江暁, 岩田倫太朗, 緒方俊彦, 岡夏央, 和田猛
- Organizer
  第20回アンチセンスシンポジウム
- Place of Presentation
  甲南大学
- Year and Date
  2010-12-02
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] New aspects for the chemical synthesis of backbone-modified nucleic acids as therapeutic agents2010
- Author(s)
  和田猛
- Organizer
  2010 The International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  ハワイコンベンションセンター、アメリカ
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] Stereocontrolled synthesis of P-chiral nucleic acid analogs as therapeutic agents2010
- Author(s)
  Wada, T.
- Organizer
  Asian 3 Roundtable on Nucleic Acids
- Place of Presentation
  関西国際空港会議場
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] New aspects for the chemical synthesis of backbone-modified nucleicacids as therapeutic agents2010
- Author(s)
  Wada, T.
- Organizer
  2010 The International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  ハワイコンベンションセンター(ホノルル,アメリカ)
- Year and Date
  2010-12-15
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] β,γ-ジアミノ酸骨格を有する新規ペプチド核酸の合成2010
- Author(s)
  斉藤敬太, 堀江暁, 岩田倫太朗, 緒方俊彦, 岡夏央, 和田猛
- Organizer
  第20回アンチセンスシンポジウム
- Place of Presentation
  甲南大学
- Year and Date
  2010-12-02
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] Bis(trifluoromethyl)ethoxymethyl (BFEM) group as a novel 2'-OH protecting group for RNA synthesis2010
- Author(s)
  Shimizu, M., Nishina, Y., Ozaki, K., Wada, T.
- Organizer
  2010 The International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  ハワイコンベンションセンター(ホノルル、アメリカ)
- Year and Date
  2010-12-15
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] Synthesis of stereoregulated 2'-O-Me phosphorothioate oligoribonucleotides2010
- Author(s)
  Khandelwal, N., Iwamoto, N., Kondo, T., Oka, N., Wada, T.
- Organizer
  第20回アンチセンスシンポジウム
- Place of Presentation
  甲南大学
- Year and Date
  2010-12-02
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] 2'-O-アルコキシメチル修飾型新規アンチセンス核酸の合成と性質2010
- Author(s)
  新井浩一郎, 内山直樹, 和田猛
- Organizer
  第20回アンチセンスシシポジウム
- Place of Presentation
  甲南大学
- Year and Date
  2010-12-02
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] H-ボラノホスホネートDNA類縁体の合成と変換反応2010
- Author(s)
  植原渉, 日浦進吾, 東田廉平, 岡夏央, 和田猛
- Organizer
  第20回アンチセンスシンポジウム
- Place of Presentation
  甲南大学
- Year and Date
  2010-12-02
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] 2'-O-アルコキシメチル修飾型新規アンチセンス核酸の合成と性質2010
- Author(s)
  新井浩一郎, 内山直樹, 和田猛
- Organizer
  第20回アンチセンスシンポジウム
- Place of Presentation
  甲南大学
- Year and Date
  2010-12-02
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] New method for the synthesis of 2'-O-arylmethyluridine derivatives2010
- Author(s)
  Uchiyama, N., Ogata, T., Oka, N., Wada, T.
- Organizer
  The 37th International Symposium on Nucleic Acids Chemistry 2010
- Place of Presentation
  みなとみらい・はまぎんホール(横浜)
- Year and Date
  2010-11-10
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] Bis(trifluoromethyl)ethoxymethyl (BFEM) group as a novel 2'-OH protecting group for RNA synthesis2010
- Author(s)
  Shimizu, M., Nishina, Y., Ozaki, K., Wada, T.
- Organizer
  2010 The International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  ハワイコンベンションセンター (ホナルル,アメリカ)
- Year and Date
  2010-12-15
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] Synthesis of stereoregulated 2'-O-Me phosphorothioate oligoribonucleotides2010
- Author(s)
  Khandelwal, N., Iwamoto, N., Kondo , T., Oka, N., Wada, T.
- Organizer
  第20回アンチセンスシンポジウム
- Place of Presentation
  甲南大学
- Year and Date
  2010-12-02
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] New method for the synthesis of 2'-O-arylmethyluridine derivatives2010
- Author(s)
  Uchiyama, N., Ogata, T., Oka, N., Wada, T.
- Organizer
  The 37th International Symposium on Nucleic Acids Chemistry 2010
- Place of Presentation
  みなとみらい・はまぎんホール(横浜)
- Year and Date
  2010-11-10
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] Stereocontrolled synthesis of oligodeoxy-ribonucleoside phosphorothioates using light fluorus chemistry2009
- Author(s)
  Wada, T.
- Organizer
  19th International Symposium on Fluorine Chemistry
- Place of Presentation
  アメリカ、ワイオミング州、ジャクソンホール
- Year and Date
  2009-08-25
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] Recent Progress of Stereocontrolled Synthesis of Backbone-modified Nucleic Acids2009
- Author(s)
  Wada, T.
- Organizer
  Joint Symposium of 5th Annual Meeting of Oligonucleotide Therapeutics Society and the 19th Antisense Symposium
- Place of Presentation
  九州大学
- Year and Date
  2009-09-28
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] リン原子の立体を制御したPS/POキメラオリゴヌクレオチドの固相合成2008
- Author(s)
  岡夏央・山本美佳・佐藤輝聴・和田猛
- Organizer
  日本化学会第88春季年会
- Place of Presentation
  立教大学池袋キャンパス
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-16350085
[Presentation] H-ホスホネートDNAの立体選択的合成とインターヌクレオチド修飾型DNA類縁体への変換反応2008
- Author(s)
  岩本直樹・岡夏央・和田猛
- Organizer
  日本化学会第88春季年会
- Place of Presentation
  立教大学池袋キャンパス
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-16350085
[Presentation] 立体が制御されたホスホロチオエートRNAの化学合成と性質2007
- Author(s)
  和田猛, 近藤知明, 藤原聡, 佐藤輝聴, 岡夏央
- Organizer
  第5回国際核酸化学シンポジウム
- Place of Presentation
  東京大学
- Year and Date
  2007-11-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350085
[Presentation] Stereocontrolled synthesis of phosphorothioate DNA and RNA by the oxazaphospholidine approach2007
- Author(s)
  Wada T
- Organizer
  第17回国際リン化学シンポジウム
- Place of Presentation
  Xiamen University
- Year and Date
  2007-04-16
- Data Source
  KAKENHI-PROJECT-16350085
[Presentation] Chemical synthesis and properties of stereoregulated phosphorothioate RNA2007
- Author(s)
  Wada T., Kondo, T., Fujiwara, S., Sato, T., Oka, N
- Organizer
  第5回国際核酸化学シンポジウム
- Place of Presentation
  東京大学本郷キャンパス
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-16350085
[Presentation] リン原子修飾型核酸の立体選択的合成のための新規保護基の開発
- Author(s)
  濱村友香、額賀陽平、和田猛
- Organizer
  日本化学会第94春季年会
- Place of Presentation
  名古屋大学
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] リン原子修飾核酸医薬の立体制御、次世代医薬「核酸医薬」創出に向けたStrategy
- Author(s)
  和田猛
- Organizer
  次世代医薬「核酸医薬」創出に向けたStrategy
- Place of Presentation
  品川コクヨホール
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] Synthesis of Boron-Containing Antisense Molecules by the H-Boranophosphonate Method
- Author(s)
  植原渉、日浦進吾、東田廉平、岡夏央、和田猛
- Organizer
  40回国際核酸化学シンポジウム
- Place of Presentation
  神奈川大学
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] 核酸医薬への合成化学的アプローチ
- Author(s)
  和田猛
- Organizer
  第25回歯工学連携講演会
- Place of Presentation
  九州工業大学
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] リン原子修飾核酸医薬の立体制御
- Author(s)
  和田猛
- Organizer
  Symposium on Innovative Research at KUT Part 1
- Place of Presentation
  高知工科大学
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] リン原子修飾糖1-リン酸誘導体の立体選択的合成
- Author(s)
  野呂美穗子、藤田正一、和田猛
- Organizer
  第32回日本糖質学会年会
- Place of Presentation
  大阪国際交流センター
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] 有機合成で創り出す核酸医薬への新しいアプローチ
- Author(s)
  和田猛
- Organizer
  第23回万有福岡シンポジウム
- Place of Presentation
  九州大学
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] 2'-O-CEM保護H-ボラノホスホネート法によるボラン修飾型RNA類縁体の固相合成
- Author(s)
  和田猛、伊藤弘暁、首藤智仁、植原渉
- Organizer
  日本化学会第94春季年会
- Place of Presentation
  名古屋大学
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] New synthetic strategies for RNA drugs
- Author(s)
  和田猛
- Organizer
  第15回RNAミーティング
- Place of Presentation
  愛媛県・県民文化会館・ひめぎんホール
- Invited
- Data Source
  KAKENHI-PLANNED-21115008

1. SEKINE Mitsuo (40111679)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. TAKESHITA Fumitaka (40466199)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. ISHIKAWA Masahide (50212858)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. TOMARI Yukihide (90447368)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KAGEYAMA Yuji (90335480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SUZUKI Takeo (90533125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. TEI Kumiko (50213327)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NAKAZAWA Takanobu (00447335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SADO Takashi (70321601)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SIOMI Mikiko (20322745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MIYAGAWA Satomi (90291153)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NAKAGAWA Shinichi (50324679)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. ODA Takeaki (00608523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YAMASHITA Akio (20405020)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NISHIMURA Yukiko (30514567)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 西川一八 (60109262)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 小茂田昌代 (50167409)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 山本美智子 (90538125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 後藤惠子 (40434047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 真野泰成 (60406254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 根岸健一 (20286363)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 宮崎智 (30290894)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 坪井麻記子 (90833905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 谷内恵介 (50626869)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. KIDA Masahide

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 高橋秀臣

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. MATSUYAMA Yuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. ABE Ryoji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 岡夏央

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
30. 横田隆徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
31. 和田健彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
32. 原倫太朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 上田宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Wada Takeshi 和田 猛

和田 猛 ワダ タケシ

WADA Takeshi 和田 猛

Research Projects

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Co-Researchers

膵癌治療への実用化を目指した新規核酸化合物のマウスモデルを用いた作用機序の検討Ongoing

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医薬品比較システム開発とそれを用いたアカデミック・ディテーリング効果に関する研究Ongoing

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Molecule selection and optimization of highly active antisense DNA and determination of absolute configuration of phosphorus atomsPrincipal InvestigatorOngoing

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Functional machinery for non-coding RNAs

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Medicinal Application of Functional Machinery for non-coding RNAsPrincipal Investigator

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Stereocontrolled synthesis of P-modified RNA nucleic acid drugsPrincipal Investigator

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New synthetic methods for the large scale synthesis of nucleic acid drugsPrincipal Investigator

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Synthesis and properties of novel artificial nucleic acid analogs having chiral backbonesPrincipal Investigator

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ボラノホスフェートDNAを用いるHIV-nefタンパク質の発現制御Principal Investigator

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Highly Efficient Synthesis of Artificial Nucleic Acids Having New FunctionsPrincipal Investigator

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修飾塩基を含むRNAの化学合成Principal Investigator

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新規アンチセンス核酸を用いるHIV-nefタンパク質の発現制御Principal Investigator

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修飾塩基を含むRNAの化学合成および構造と機能の探索Principal Investigator

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Wada Takeshi 和田猛

和田猛ワダタケシ

WADA Takeshi 和田猛