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Fujii Nobutaka  藤井 信孝

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… Alternative Names

FUJII Nobutaka  藤井 信孝

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Researcher Number 60109014
Other IDs
External Links
Affiliation (Current) 2019: 京都大学, 薬学研究科, 名誉教授
Affiliation (based on the past Project Information) *help 2017: 京都大学, 薬学部, 名誉教授
2017: 京都大学, 薬学部, 教授
2015 – 2017: 京都大学, 薬学研究科, 名誉教授
2011 – 2014: 京都大学, 薬学研究科(研究院), 教授
1997 – 2008: Kyoto University, Graduated School of Pharmaceutical Sciences, Professor, 薬学研究科, 教授 … More
2006: 京都大学, 薬学部, 教授
2001: Graduate School of Pharmaceutical Sciences, Kyoto University, Professor, 薬学研究科(研究院), 教授
1999 – 2001: 京都大学, 大学院・薬学研究科, 教授
1989 – 1996: Faculty of Pharmaceutical Sciences, Kyoto Univ. Professor., 薬学部, 教授
1987 – 1988: Faculty of Pharmaceutical Sciences, Kyot University, 薬学部, 助教授
1986: 京大, 薬学部, 助教授 Less
Review Section/Research Field
Principal Investigator
Biological Sciences / 医薬分子機能学 / Drug development chemistry / Chemical pharmacy / Bioorganic chemistry
Except Principal Investigator
Chemical pharmacy / Digestive surgery / Bioorganic chemistry / 膠原病・アレルギー・感染症内科学 / Physical pharmacy … More / Biological Sciences / Pathological medical chemistry / Biomedical engineering/Biomaterial science and engineering / General surgery Less
Keywords
Principal Investigator
CXCR4 / ケモカイン / 癌 / CXCR4拮抗剤 / 環状ペプチド / GPR54 / 構造活性相関 / T140 / HIV第二受容体拮抗剤 / T22 … More / 有機銅試薬 / gp41 / 創薬テンプレート / ジスルフィド形成反応 / マラリア / Plasmepsin II / aza-Payne転位反応 / 基質遷移状態模倣型酵素阻害剤 / de novo設計 / HIV-cell融合阻害剤 / ケモカイン受容体 / 乳癌 / 膵臓癌 / 小細胞肺癌 / SARS Corona Virus / 膜融合阻害剤 / SDF-1 / 薬剤耐性 / コンビナトリアル合成 / キナーゼ / 複素環 / CXCR4ケモカイン受容体 / FC131 / tachyplesin / polyphemusin / ボンベシンアンタゴニスト / 抗腫瘍活性 / Bombesin Antagonist / ペプチドイソスター / 立体配座固定 / エイズ / HIVプロテアーゼ阻害剤 / Constitutively Active Receptor Technology / G-protein coupled receptor / GPCR / Plasmodium falciparum / ChondroitinsulfateA / Duffy-結合様ドメイン / マラリアワクチン / T-細胞指向性HIV / ケモカインレセプター / Pd(0) / Ru-触媒オレフィンメタセシス / HIV-cell膜融合阻害剤 / 6-helical bundle / X-線解析 / SC34 / MAGI assay / Spring 8 / 3-ヘリックスバンドル構造 / 多剤耐性株 / 化学合成ワクチン / T20 / MAGI細胞 / 受容体 / 膜タンパク質 / ペプチドチオエステル / 脂質二重膜 / タンパク質合成 / HIV / 脂質膜 / リポソーム / 癌転移 / 血液癌 / メラノーマ / 慢性リンパ性B-Cell白血病 / 癌転移抑制剤 / 骨髄ストローマ細胞依存性薬剤耐性 / 新興・再興ウイルス / I-型ウイルス-宿主細胞膜融合 / SARSCoV / VERO-E6細胞 / 猫エイズ / インフルエンザウイルス / HIV膜融合阻害剤 / XEEXXKK概念 / Bioinformatics / SARS CoVゲノム / defensin / 比較ゲノミクス / Nelfinavir / X-EE-XX-KK配列 / CXCR4-ケモカイン受容体 / 癌の化学療法剤 / 癌転移メカニズム / ストローマ細胞依存性薬物耐性 / 立体配座固定創薬テンプレート / ALL / Eg5 / Kisspeptin / kisspeptin / 化合物バンク / ドラッグ指向性 / ケミカルバイオロジー / 多成分反応 / イソキノリン / キノリン / インドリン / インドール / 固相反応 / CXCR7 / CK2 / KSP / キネシン / CXCR7ケモカイン受容体 / ホモロジーモデル / プロテインキナーゼCK2 / スフィンゴシンキナーゼ / jaspine B / キネシンモータータンパク / 分子設計 / ドラッグライク / 複素環骨格構築反応 / 天然物 / 化合物ライブラリー / スクリーニング / アッセイ / 生物活性化合物 / 鏡像体 / 天然有機化合物 / ヒトコレシストキニン全合成 / 選択的硫酸エステル化 / トリメチルシリルトリフルオロメタンスルホネート / 膵蛋白放出活性 / カルシトニン遺伝子関連ペプチド(cGRP) / Sー保護システインスルホキシド / トリメチルシリルトリフルオロメタンスルホネート(TMSOTf) / エンドセリン / ビッグエンドセリン / Sー脱保護試薬 / トリフルオロメタンスルホン酸銀 / トリメチルシリルブロマイド / 血管収縮作用 / システインのSH保護基 / Caイオンチャンネル / Endothelin / Big Endothelin / S-Deprotecting Reagent / Silver Trifluoromethanesulphonate / 老人性痴呆 / アルツハイマー型痴呆 / 神経栄養因子 / 化学選択的精製法 / Trk受容体 / Tau蛋白質 / 非水解性リン酸化ペプチド / NGF合成促進因子 / アルツハイマー / NGF / フラグメント縮合 / 二価官能性試薬 / 化学選択的固定化 / ジメチルスルホキシド / ジスルフィド形成 / 老人性痴呆症 / Biotin化試薬 / アフィニテイークロマト / Arg-vasopressin(4-9) / Senile Dementia / Alzheimer Disase / Neurotrophin / Chemoselective Purification / Disulfide-bond Formation / Trk-receptor / Tau-protein / Nonhydrolyzable Phosophopeptide / 抗HIV活性 / β‐sheet / T細胞 / 液相合成 / AgOTf‐DMSO / HCl / AgOTf / DMSO / NMR / β-sheet / anti-HIV activity / beta-sheet / T cell / AgOTf-DMSO / HCI / solution-phase synthesis / 活性化アジリジンエノエ-ト / 0価パラジウム / (E)-アルケンジペプチドイソスター / アミラーゼ分泌抑制 / 立体制御合成プロセス / キラルプール / 立体特異的1,3-不斉転移 / (E)-アルケン型ジペプチドイソスター / 遷移金属触媒による異性化反応 / 膵癌細胞増殖抑制 / Organocopper Reagents / Activated Aziridinyl Enoates / Palladium(0) / (E)-Alkene Dipeptide Isosters / Inhibition of Amylase Release / Anti-Cancer Activity / Stereocontrolled Synthetic Route / 有機銅化合物 / ボンベシン・アンタゴニスト / SN2型開環反応 / アルケンイソスター / アジリジニル・エノエイト / ビニルアジリジン / 有機パラジウム化合物 / アリルパラジウム錯体 / トリプトファン・イソスター / トリプトフアン・イソスター / Organocopper Compound / SN2-type Ring-Opening / Alkene Isostere / Aziridinylenoate / Vinylaziridine / Organopalladium Compound / Allylpalladium Complex / 立体的選択的合成反応 / アスパルチルプロテアーゼ / 基質遷移状態模倣型阻害剤 / aza-Payne転位 / β-セクレターゼ / HIVプロテアーゼ / アルケン型ジペプチドイソスター / ゲノム情報集約型ライブラリー / αVβ3インテグリン拮抗剤剤 / アルツハイマー型痴呆症 / 有機亜鉛-銅複合試薬 / ペプチドリード医薬品 / Ru-触媒メタセシス閉環反応 / グローバル配座固定 / β-secretase / 多剤耐性HIV型プロテアーゼ / オレフィンメタセシス閉環反応 / (E)-Alkcnc型dipcptidcisostcrc / 非天然型アミノ酸誘導体 / 基質遷移状態ミミック構造 / 遷移金属触媒 / ケモカインアンタゴニスト / Stereoselective Synthesis / Aspartyl Protease / Substrate Transition State Mimic / aza-Payne Rearrangement / β-Secretase / HIV-protease / Organocopper Reagent / Alkene-type tipeptide isostere / HIV進入阻害剤 / CXCR4ケモカインレセプター / T細胞指向性HIV / 多剤耐性HIV / 低分子化 / de novo分子設計 / CXCR4アンタゴニスト / HIV侵入阻害剤 / T細胞指向性HIV-1 / 環状ペンタペプチドライブラリー / ホモロジーモデリング / 機能性CXCR4変異体 / T140-CXCR4ドッキング解析 / gp41-標的型HIV-Cell膜融合阻害剤 / SC34EK / spring8 / 多剤耐性克服型抗HIV剤 / 二価官能性抗HIV剤 / T140立体構造 / 逆転写酵素阻害 / エイス / 有用金属試薬 / anti-HIV agents / chemokine receptor / T-cell line-tropic HIV / low molecular weight CXCR4 antagonists / HIV-cell fusion inhibitors / de novo design / ゲノム科学 / 創薬研究 / ペプチド化学 / Chemical Ligation / 7回膜貫通型GPCR / ゲノム情報 / 蛋白質化学 / 7回膜貫通型レセプター / HIV感染 / Germinal Center / リウマチ / ゲノム / プロテオーム / 7TM-GPCR / αVβ3-integrin / ユニバーサル創薬テンプレート / genome science / drug discovery / peptide-isosteres / Peptide Chemistry / CXCR4 antagonist / chemical ligation / 7回膜貫通型受容体 / ケミカルプロテオミクス / 7TMGPCR / Cysteine-ligation / 光感受性保護基 / GPR-54 / 非ペプチド化 / Bioluminescece Resonance Energy Transfer / Intein-splicing system / Seven transmembrane protein / chemical proteomics / ヒト腫瘍増殖因子-α / 成長因子 / 腫瘍細胞増殖 / 1Mトリメチルシリルトリフルオロメタンスルホネート / トリフルオロメタンスルホン酸銀塩 / ヒト腫瘍細胞増殖因子α / 【N^(ih)】-benzyloxymethyl histidine / 癌診断 / トリメチルシリルトリフラート / タリウム(【III】)酸化 / human transforming growth factor-<alpha> / mitogenic factor / cancer cell growth / 1 M trimethylsilyl trifluoromethanesulfonate / ペプチド / 合理的分子設計 … More
Except Principal Investigator
EGF / 膵再生 / ハイブリッド型人工膵 / 免疫抑制剤 / ペプチド合成 / DDS / 不斉合成 / Avidin-biotin / p16 / DNA認識 / DNA切断 / 抗腫瘍性抗生物質 / ダイネミシン / ブレオマイシン / エナペラミシン / ポルフィリン / プタキロサイド / エンドセリン / 膵炎 / ラ島移植 / 異種移植 / 急性膵炎 / アッセイ / シオニン / 分離ラ島 / MRPT / バッグタイプ人工膵 / 生体機能性ペプチド / ペプチド科学 / 生体内信号 / ペプチド三次構造 / 構造活性相関 / 分子設計 / 重点領域 / ペプチドイソスター / アルケン / GRP拮抗剤 / ペプチドリード医薬品 / (E)-アルケン型ジペプチドイソスター / GRP / ボンベシン / 有機銅試薬 / 還元的アルキル化 / パラジウム触媒 / 抗菌薬 / 好中球 / 感染症 / ポリビニ-ルアルコ-ル / 移植 / 成熟ブタ分離ラ氏島 / 胃切除後胆石 / GIP / 成熟ブタ膵ラ氏島 / 膵外分泌 / 肝血流 / ハイブリッド人工膵 / 成熟ブタ ラ氏島 / EGF & Pancreatic regeneration / GIP & splanchnic circulation / Endothelin & pancreas / Post-gastrectomy gallstone / FK506 and cyclosporine / Isolation of islet from adult pit pancreas / Hybrid islet pancreas with MRPT / Transplantation / ヒペルシン / トリコポリン / マガイニン / タキプレシン / 脂質膜 / 膜透過性 / コンホメ-ション / 配向 / タチプレシン / Hypelcin / Trichopolyn / Magainin / Tachyplesin / Lipid membrane / Membrane permeability / Conformation / Orientation / 生理活発微量天然物合成 / 有機金属化合物の利用 / アミノ酸装飾 / 不斉合成素子の開発 / 有用酵素の量的供給 / 生理活性微量天然物合成 / アミノ酸修飾 / 生物活性天然物 / 海洋性天然物 / 甘味成分 / アレニルスルホニウム / Tautomycin,A / Protein Phosphayase Inhibitor / Biologically active natural products / Asymmetric Synthesis / Organometalic Chenistry / Modification of amino acid / Development of chiral synthon / Ample supply of useful enzymes / 固相合成 / ジスルフィド結合 / 生体防御ペプチド / プロテグリン / デフェンシン / アフィニティークロマト / Solid-phase synthesis / Disulfide bond / Self-defense peptide / Protegrin / Defensin / Affinity purification / プロテアーゼ阻害剤 / CCR5阻害剤 / 薬剤耐性 / CXCR4阻害剤 / 膜融合阻害剤 / Vprトランスジェニックマウス / 中和抗体 / 逆転写酵素阻害剤 / HIV-1 / T140 / CXCR4拮抗剤 / トランスジェニックマウス / 遺伝子発現制御 / hu-PBL-SCIDマウス / ケモカインレセプター阻害剤 / 発症予防ワクチン / 抗ウイルス剤 / CTL / tat / 転写制御 / フィットネス / rev / u-CRM1 / Protease inhibitor / CCR5 inhibitor / Drug resistance / CXCR4 inhibitor / Membrane fusion inhibitor / Vpr transgenic mouse / Neutralizing antibody / Reverse transcriptase inhibitor / アポトーシス / Bcl-X遺伝子 / シグナル伝達 / インテグリンαvβ3 / 膵癌 / DcR3 / 膵癌治療 / 遺伝子 / 受容体 / Apoptosis / Bcl-X gene / Signal transduction / integrin αV β3 / Pancreatic cancer / 5ーデアザフラビン / Pー450モデル / オリゴヌクレオチド / レチノイド / オピオイド受容体 / エスペラミシン / 面不斉5-デアザフラビン / P-450モデル / 修飾オリゴフクレオチド / ペプチヂ合成 / 5-デアザフラビン / ヒトパンクレオスタチン / 核酸 / 蛋白質 / 機能性分子の合成 / 作用機序の解明 / レセプター / 生物有機化学 / 生物活性物質 / Chiral 5-deazaflavin / Retinoid / P-450 model / Modified oligonucleotide / Chiral synthesis / Peptide synthesis / Opioid receptor / Esperamicin / 非対称ジスルフィルド形成反応 / Sー保護システインスルホキシド / カルシトニン遺伝子関連ペプチド / インシュリン / リラキシン / 非対称シスチンペプチド / ニワトリカルシトニン遺伝子関連ペプチド / 非対称シスチン含有ペプチドの合成法インシュリンの改良合成 / リラキシンの全合成 / Thallium (III) oxidation / Sulfoxide-directed disulfide bond forming reaction / Open-chain unsymmetrical cystine peptide / CGRP / Insulin / Txnip / 糖尿病 / 癌 / インスリン抵抗性 / 低分子化合物 / スクリーニング / ケミカルバイオロジー / 創薬 / 癌抑制 / アルファアレスチン / イノベーション / TBP-2 / 化合物スクリーニング / 低分子化合物スクリーニング / 抗HIV / 抗HIVペプチド / 薬物送達 / ポリペプチド / 高分子型プロドラッグ / 人工エラスチン / 注射ゲル製剤 / 創剤 / ペプチド製剤 / 徐放 / エラスチン / 生体材料 / 注射ゲル / 生分解材料 / デポ製剤 / kinesin spindle protein / 乳癌 / 微小管阻害薬 / 末梢神経障害 / KSP Less

  • Research Projects

    (45 results)

  • Research Products

    (601 results)

  • Co-Researchers

    (86 People)

  •  Development of Novel Drug Discovery Technologies for Target Proteins with Elusive Molecular BasisPrincipal Investigator

    • Principal Investigator
      Fujii Nobutaka
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      Kyoto University

  •  Development of anti HIV peptide applying multifunctional polypeptide

    • Principal Investigator
      Nakashima Hideki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biomedical engineering/Biomaterial science and engineering
    • Research Institution
      St. Marianna University School of Medicine

  •  Potential new chemotherapy for breast cancer therapy with a novel KSP inhibitor

    • Principal Investigator
      Ohta Yuki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      St. Marianna University School of Medicine

  •  Elucidation of the molecular mechanism of insulin resistance by investigating TBP-2/Txnip and chemical biology

    • Principal Investigator
      MASUTANI Hiroshi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kyoto University

  •  Development and application of a novel screening technolgy toward effective uses of chemical libraryPrincipal Investigator

    • Principal Investigator
      FUJII Nobutaka
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Drug development chemistry
    • Research Institution
      Kyoto University

  •  Practical medicinal chemistry on the basis of protein chemistry, computational science and synthetic technologies for a variety of heterocyclesPrincipal Investigator

    • Principal Investigator
      FUJII Nobutaka
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      Kyoto University

  •  多重標的創薬概念に基づくがん化学療法の新機軸Principal Investigator

    • Principal Investigator
      大石 真也, 藤井 信孝
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University

  •  GPCR周辺の細胞外環境解明のためのケミカルプローブの創出と応用Principal Investigator

    • Principal Investigator
      大石 真也, 藤井 信孝
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University

  •  癌転移・骨髄依存薬物耐性の動的超分子機構解明のケミカルプローブ創出と創薬展開Principal Investigator

    • Principal Investigator
      藤井 信孝
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University

  •  有機化学を基盤にしたGPCR細胞外環境のケミカルバイオロジー研究Principal Investigator

    • Principal Investigator
      藤井 信孝
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University

  •  ドラッグ指向性化合物バンクの構築と創薬展開Principal Investigator

    • Principal Investigator
      藤井 信孝
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Drug development chemistry
    • Research Institution
      Kyoto University

  •  CXCR4を分子標的とした癌転移およびストローマ細胞依存性薬物耐性の克服Principal Investigator

    • Principal Investigator
      藤井 信孝
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University

  •  好中球を利用した抗菌薬を感染病巣に到達させる特異的DDSの開発

    • Principal Investigator
      笹田 昌孝
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Kyoto University

  •  Evolution of Drug Discovery Targeting for G-protein Coupled ReceptorsPrincipal Investigator

    • Principal Investigator
      FUJII Nobutaka
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Drug development chemistry
    • Research Institution
      Kyoto University

  •  CXCR4を標的とする癌転移抑制剤の開発Principal Investigator

    • Principal Investigator
      藤井 信孝
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University

  •  生物情報科学を活用した新興ウイルス性感染症に対する化学療法剤の実践的開発戦略研究Principal Investigator

    • Principal Investigator
      藤井 信孝
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Drug development chemistry
    • Research Institution
      Kyoto University

  •  腫瘍転移抑制剤を指向した実用的CXCR4アンタゴニストの開発研究Principal Investigator

    • Principal Investigator
      藤井 信孝
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University

  •  ケミカルレセプトームの開発と応用Principal Investigator

    • Principal Investigator
      藤井 信孝
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      医薬分子機能学
    • Research Institution
      Kyoto University

  •  Genome/Proteome-lead Drug Discovery Based on Peptide/Protein ChemistryPrincipal Investigator

    • Principal Investigator
      FUJII Nobutaka
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      医薬分子機能学
    • Research Institution
      Kyoto University

  •  HIV-Cell融合遷移状態を標的とした化学合成ワクチンの開発Principal Investigator

    • Principal Investigator
      藤井 信孝
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Chemical pharmacy
    • Research Institution
      Kyoto University

  •  DEVELOPMENT OF NOVEL ANTI -HIV AGENTS BASED ON HIGHLY' SELECTIVE CHEMOKINE RECEPTOR CXCR$ ANTAGONISTSPrincipal Investigator

    • Principal Investigator
      FUJII Nobutaka
    • Project Period (FY)
      2000 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      KYOTO UNIVERSITY

  •  マラリア原虫の増殖機構をターゲットとする新規マラリア治療薬の開発研究Principal Investigator

    • Principal Investigator
      藤井 信孝
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyoto University

  •  低分子CXCR4アンタゴニストT22を基盤構造とした抗エイズ治療薬の開発研究Principal Investigator

    • Principal Investigator
      藤井 信孝
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University

  •  (E)-アルケンペプチドイソスターを探索子とする高活性GRP拮抗剤の創製

    • Principal Investigator
      大高 章
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyoto University

  •  Basic Research for AIDS control A03 ; Prevention and control of AIDS

    • Principal Investigator
      MATSUSHITA Shuzo
    • Project Period (FY)
      1998 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      KUMAMOTO UNIVERSITY

  •  Molecular cancer therapy based on the pathological analysis of the pancreatic cancer

    • Principal Investigator
      HOSOTANI Ryo
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Digestive surgery
    • Research Institution
      KYOTO UNIVERSITY

  •  Studies on Practical Strategy for Peptide-lead Drug Discovery and DevelopmentPrincipal Investigator

    • Principal Investigator
      FUJII Nobutaka
    • Project Period (FY)
      1998 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      KYOTO UNIVERSITY

  •  (E)-アルケンペプチドイソスターを探索子とする高活性GRP拮抗剤の創製

    • Principal Investigator
      OTAKA Akira
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto University

  •  Development of highly efficient, selective, and practical synthetic method of pseudo-peptides possessing anti-tumour activity.Principal Investigator

    • Principal Investigator
      FUJII Nobutaka, 井深 俊郎
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      KYOTO UNIVERSITY

  •  Synthesis of Peptide Isosteres with Strong Bombesin Antagonist Activity and Its Development to Anti-Cancer AgentsPrincipal Investigator

    • Principal Investigator
      FUJII Nobutaka
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      KYOTO UNIVERSITY

  •  機能性ペプチドの分子設計における新展開

    • Principal Investigator
      宗像 英輔
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      Bioorganic chemistry
    • Research Institution
      University of Tsukuba

  •  Synthetic Studies for Ample Supply of Biologically Active Natural Products

    • Principal Investigator
      IRIE Hiroshi
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Ngasaki University

  •  Synthetic Study on Neurotrophins and Its Application for Development of Diagnostic Immunoassay Method for Senile DementiaPrincipal Investigator

    • Principal Investigator
      FUJII Nobutaka
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Bioorganic chemistry
    • Research Institution
      KYOTO UNIVERSITY

  •  Development of efficient synthetic methods for peptides and syntheses of self-defense peptides possessing anti-virus activity

    • Principal Investigator
      OTAKA Akira
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      KYOTO UNIVERSITY

  •  Studies on the elucidantion of action mechanisms of tachyplesin analogs as anti-HIV peptidesPrincipal Investigator

    • Principal Investigator
      FUJII Nobutaka
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      医薬分子機能学
    • Research Institution
      KYOTO UNIVERSITY

  •  消化管ホルモンを介する臓器相関

    • Principal Investigator
      INOUE Kazutomo
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyoto University

  •  生物活性分子による核酸の精密構造認識と機能発現

    • Principal Investigator
      杉浦 幸雄
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto University

  •  Effect of Gastrointestinal Hormones on Organ Interrelationship

    • Principal Investigator
      INOUE Kazutomo, TOBE Takayoshi
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyoto University

  •  Interactions of antibiotic peptides with lipid membranes

    • Principal Investigator
      MIYAJIMA Koichiro
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      Kyoto University

  •  Synthetic Studies on Endothelin and Its Related Peptides Using a New S-Derotecting ReagentPrincipal Investigator

    • Principal Investigator
      FUJII Nobutaka
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Kyoto University

  •  新しいジスルフィド形成反応を用いるカルシトニン遺伝子関連ペプチドの合成研究Principal Investigator

    • Principal Investigator
      藤井 信孝
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Kyoto University

  •  選択的硫酸エステル化法によるヒトコレシストキニンの全合成Principal Investigator

    • Principal Investigator
      藤井 信孝
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Kyoto University

  •  New Frontier in Bioorganic Chemistry Research

    • Principal Investigator
      YONEDA Fumio
    • Project Period (FY)
      1987 – 1989
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Kyoto University

  •  Exploitation of a New Unsymmetrical Disulfide-Bonding Reaction and Its Application to the Synthesis of Cystine-Conatining Peptides

    • Principal Investigator
      YAJIMA Haruaki
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Kyoto University

  •  Synthetic Studies on Human Transforming Growth Factor(hTGF)-<alpha>Principal Investigator

    • Principal Investigator
      FUJII Nobutaka
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Kyoto University

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Book

  • [Book] ケミカルバイオロジー研究を基盤にした抗癌剤の創出：KSP阻害剤の創出2012
    • Author(s)
      竹内智起、大石真也、藤井信孝
    • Publisher
      メディカルドゥ
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Book] インシリコ創薬科学2008
    • Author(s)
      大石真也、藤井信孝、他
    • Total Pages
      210
    • Publisher
      京都廣川書店
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Book] インシリコ創薬科学2008
    • Author(s)
      大石真也、藤井信孝、他
    • Total Pages
      210
    • Publisher
      京都廣川書店
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Book] Screening and characterization of cyclic pentapeptide CXCR4 antagonists/inverse agonists using a pheromone responsive reporter gene in Saccharomyces cerevisiae: utility of G plotein coupled receptor constitutively active mutants2007
    • Author(s)
      Fujii N., et. al.
    • Publisher
      Birkhaeuser
    • Data Source
      KAKENHI-PROJECT-18659027

  • [Book] プロテオミクスを基盤とするケミカルバイオロジー-情報から制御へ2006
    • Author(s)
      藤井信孝, 他
    • Total Pages
      6
    • Publisher
      オーム社
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Book] 細胞工学(特集)飛躍するケミカルバイオロジー:科学から生命現象を明らかに(分担執筆)2005
    • Author(s)
      藤井信孝, 大高 章, 玉村啓和
    • Total Pages
      6
    • Publisher
      秀潤社
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Book] Chemokine Roles in Immunoregulation and Disease(ed by P.M.Murphy & R.Horuk)2004
    • Author(s)
      H.Zhang, N.Fujii, S.C.Peiper, et al.
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-14207099

  • [Journal Article] Head-to-tail macrocyclization of cysteine-free peptides using an o -aminoanilide linker2018
    • Author(s)
      T. Ohara, M. Kaneda, T. Saito, N. Fujii, H. Ohno, S. Oishi
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 28 Pages: 1283-1286

    • DOI

      10.1016/j.bmcl.2018.03.027

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15KT0061, KAKENHI-PROJECT-15H04654, KAKENHI-PROJECT-15J05499

  • [Journal Article] Synthesis of jaspine B regioisomers through palladium-catalyzed stereoselective tetrahydrofuran formation: Insight into the ligand recognition of sphingosine kinases2018
    • Author(s)
      Miyagawa, S. Inuki, M. Honda, S. Nakamura, I. Nakanishi, N. Fujii, S. Oishi, H. Ohno
    • Journal Title

      Tetrahedron

      Volume: 74 Pages: 1802-1809

    • DOI

      10.1016/j.tet.2018.02.042

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15KT0061, KAKENHI-PROJECT-15H04654, KAKENHI-PUBLICLY-18H04408

  • [Journal Article] Relationship Study of Cyclic Pntapeptide Ligands for Atypical Chemokine Receptor 3 (ACKR3)2018
    • Author(s)
      Sekiguchi Haruka、Kuroyanagi Tomoko、Rhainds David、Kobayashi Kazuya、Kobayashi Yuka、Ohno Hiroaki、Heveker Nikolaus、Akaji Kenichi、Fujii Nobutaka、Oishi Shinya
    • Journal Title

      J. Med. Chem.

      Volume: 61 Pages: 3745-3751

    • DOI

      10.1021/acs.jmedchem.8b00336

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04654, KAKENHI-PROJECT-16H05104

  • [Journal Article] Identification of selective inhibitors of sphingosine kinases 1 and 2 through a structure?activity relationship study of 4- epi -jaspine B2017
    • Author(s)
      H. Ohno, M. Honda, N. Hamada, J. Miyagaki, A. Iwata, K. Otsuki, T. Maruyama, S. Nakamura, I. Nakanishi, S. Inuki, N. Fujii, S. Oishi
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 25 Pages: 3046-3052

    • DOI

      10.1016/j.bmc.2017.03.059

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24689001, KAKENHI-PROJECT-15KT0061, KAKENHI-PROJECT-15H04654, KAKENHI-PROJECT-17H03971

  • [Journal Article] A Novel KSP Inhibitor, KPYB10602, Induces Mitotic Arrest and Cell Death in Breast Cancer Cells2016
    • Author(s)
      Kojima-Tsuchiya Seiko, Ohta Yuki, Takenaga Mitsuko, Niimi Jun, Watanabe Daiki, Tsunoda Satoshi, Ootaki Masanori, Oishi Shinya, Fujii Nobutaka, Matsumoto Naoki, Tsugawa Koichiro
    • Journal Title

      Journal of St.Marianna University

      Volume: 7 Pages: 105-116

    • NAID

      130005251535

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10074

  • [Journal Article] Development of novel NK3 receptor antagonists with reduced environmental impact2016
    • Author(s)
      Yamamoto Koki、Okazaki Shiho、Ohno Hiroaki、Matsuda Fuko、Ohkura Satoshi、Maeda Kei-ichiro、Fujii Nobutaka、Oishi Shinya
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 24 Pages: 3494-3500

    • DOI

      10.1016/j.bmc.2016.05.054

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Journal Article] Screening of a virtual mirror-image library of natural products.2016
    • Author(s)
      T. Noguchi, S. Oishi, K. Honda, Y. Kondoh, T. Saito, H. Ohno, H. Osada, N. Fujii
    • Journal Title

      Chem Comm

      Volume: 52 Pages: 7653-7656

    • DOI

      10.1039/c6cc03114e

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04653, KAKENHI-PROJECT-15H04654, KAKENHI-PROJECT-14J07738, KAKENHI-PROJECT-26350976

  • [Journal Article] Total Synthesis of (+)-Conolidine by the Gold(I)-Catalyzed Cascade Cyclization of a Conjugated Enyne2016
    • Author(s)
      S. Naoe, Y. Yoshida, S. Oishi, N. Fujii, H. Ohno
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 81 Pages: 5690-5698

    • DOI

      10.1021/acs.joc.6b00720

    • NAID

      120006634624

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24689001, KAKENHI-PROJECT-15KT0061, KAKENHI-PROJECT-15H04654

  • [Journal Article] Formal Total Synthesis of (±)-Strictamine Based on a Gold-Catalyzed Cyclization2016
    • Author(s)
      D. Nishiyama, A. Ohara, H. Chiba, H. Kumagai, S. Oishi, N. Fujii, H. Ohno
    • Journal Title

      Org. Lett.

      Volume: 18 Pages: 1670-1673

    • DOI

      10.1021/acs.orglett.6b00536

    • NAID

      120006634625

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15KT0061, KAKENHI-PROJECT-24689001, KAKENHI-PROJECT-15H04654

  • [Journal Article] Structure-Activity Relationship Study of 4-(Thiazol-5-yl)benzoic Acid Derivatives as Potent Protein Kinase CK2 Inhibitors2016
    • Author(s)
      H. Ohno, D. Minamiguchi, S. Nakamura, K. Shu, S. Okazaki, M. Honda, R. Misu, H. Moriwaki, S. Nakanishi, S. Oishi, T. Kinoshita, I. Nakanishi, N. Fujii
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 24 Pages: 1136-1141

    • DOI

      10.1016/j.bmc.2016.01.043

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15KT0061, KAKENHI-PROJECT-24689001, KAKENHI-PROJECT-15H04654

  • [Journal Article] Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors2016
    • Author(s)
      Alam, M., Kuwata, T., Shimura, K., Yokoyama, M., Ramirez Valdez, K. P., Tanaka, K., Maruta, Y., Oishi, S., Fujii, N., Sato, H., Matsuoka M. and Matsushita S.
    • Journal Title

      Retrovirology

      Volume: 13 Pages: 70-70

    • DOI

      10.1186/s12977-016-0304-7

    • NAID

      120005973385

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26430091, KAKENHI-PROJECT-16K08824, KAKENHI-PROJECT-15H04654, KAKENHI-PROJECT-15H04870

  • [Journal Article] CXCL12/CXCR4 pathway is activated by oncogenic JAK2 in a PI3K-dependent manner2016
    • Author(s)
      Abdelouahab Hadjer、Zhang Yanyan、Wittner Monika、Oishi Shinya、Fujii Nobutaka、Besancenot Rodolphe、Plo Isabelle、Ribrag Vincent、Solary Eric、Vainchenker William、Barosi Giovanni、Louache Fawzia
    • Journal Title

      Oncotarget

      Volume: 8 Pages: 54082-54095

    • DOI

      10.18632/oncotarget.10789

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Journal Article] Novel 3,4,7-Substituted Benzofuran Derivatives Having Binding Affinity to κ-Opioid Receptor2016
    • Author(s)
      D. Nishiyama, Y. Sakai, H. Sekiguchi, H. Chiba, R. Misu, S. Oishi, N. Fujii, H. Ohno
    • Journal Title

      CHEMICAL & PHARMACEUTICAL BULLETIN

      Volume: 64 Issue: 7 Pages: 996-1003

    • DOI

      10.1248/cpb.c16-00302

    • NAID

      130005160050

    • ISSN
      0009-2363, 1347-5223
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24689001, KAKENHI-PROJECT-15KT0061, KAKENHI-PROJECT-15H04654

  • [Journal Article] A Novel Peptide Derived from the Fusion Protein Heptad Repeat Inhibits Replication of Subacute Sclerosing Panencephalitis Virus In Vitro and In Vivo2016
    • Author(s)
      Watanabe M, Hashimoto K, Abe Y, Kodama EN, Nabika R, Oishi S, Ohara S, Sato M,Kawasaki Y, Fujii N, Hosoya M.
    • Journal Title

      PLOS ONE

      Volume: 11

    • DOI

      10.1371/journal.pone.0162823

    • NAID

      120005997738

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05346, KAKENHI-PROJECT-15H04654

  • [Journal Article] Development of novel neurokinin 3 receptor (NK3R) selective agonists with resistance to proteolytic degradation2015
    • Author(s)
      Misu R, Oishi S, Yamada A, Yamamura T, Matsuda F, Yamamoto K, Noguchi T, Ohno H, Okamura H, Ohkura S, Fujii N.
    • Journal Title

      Journal of Medicinal Chemistry

      Volume: 57 Pages: 8646-8651

    • DOI

      10.1021/jm500771w

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-12J06309, KAKENHI-PROJECT-14J07738, KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-23689007, KAKENHI-PROJECT-24380154

  • [Journal Article] Formal [4 + 2] Reaction between 1,3-Diynes and Pyrroles: Gold(I)-Catalyzed Indole Synthesis via Double Hydroarylation2015
    • Author(s)
      Matsuda Y, Naoe S, Oishi S, Fujii N, Ohno H.
    • Journal Title

      Chem. Eur. J.

      Volume: 21 Pages: 1463-1467

    • DOI

      10.1002/chem.201405903

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-24689001

  • [Journal Article] Potential new chemotherapy strategy for human ovarian carcinoma with a novel KSP inhibitor.2015
    • Author(s)
      Takenaga, M., Yamamoto, Y., Takeuchi T., Ohta, Y., Tokura, Y., Hamaguchi, A., Asai, D., Nakashima, H., Oishi, S., and Fujii, N.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 463 Pages: 222-228

    • DOI

      10.1016/j.bbrc.2015.05.029

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K01319, KAKENHI-PROJECT-26460050, KAKENHI-PROJECT-25462618

  • [Journal Article] Synthesis and biological evaluation of the [D-MeAla11]-epimer of coibamide A2015
    • Author(s)
      Nabika R, Suyama TL, Hau AM, Misu R, Ohno H, Ishmael JE, McPhail KL, Oishi S, Fujii N.
    • Journal Title

      Bioorganic Medicinal Chemistry Letters

      Volume: 25 Pages: 302-306

    • DOI

      10.1016/j.bmcl.2014.11.044

    • NAID

      120005555485

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-12J06309, KAKENHI-PROJECT-14J07872, KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-24659004

  • [Journal Article] Structure-activity relationship study on senktide for development of novel potent neurokinin-3 receptor selective agonists2015
    • Author(s)
      Misu R, Yamamoto K, Yamada A, Noguchi T, Ohno H, Yamamura T, Okamura H, Matsuda F, Ohkura S, Oishi S, Fujii N.
    • Journal Title

      Medicinal Chemistry Communications

      Volume: 6 Pages: 469-476

    • DOI

      10.1039/c4md00514g

    • NAID

      120005615647

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-12J06309, KAKENHI-PROJECT-14J07738, KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-23689007, KAKENHI-PROJECT-24380154

  • [Journal Article] Synthesis of Fused Carbazoles by Gold-Catalyzed Tricyclization of Conjugated Diynes via Rearrangement of an N-Propargyl Group2015
    • Author(s)
      M. Taguchi, Y. Tokimizu, S. Oishi, N. Fujii, H. Ohno
    • Journal Title

      Org. Lett.

      Volume: 17 Pages: 6250-6253

    • DOI

      10.1021/acs.orglett.5b03254

    • NAID

      120006634626

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15KT0061, KAKENHI-PROJECT-24689001, KAKENHI-PROJECT-15H04654

  • [Journal Article] Dual Gold Catalysis: A Novel Synthesis of Bicyclic and Tricyclic Pyrroles from N-Propargyl Ynamides2015
    • Author(s)
      Tokimizu Y, Wieteck M, Rudolph M, Oishi S, Fujii N, Hashmi ASK, Ohno H.
    • Journal Title

      Org. Lett.

      Volume: 17 Pages: 604-606

    • DOI

      10.1021/ol503623m

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-24689001

  • [Journal Article] Gold-Catalyzed Cascade Cyclization of (Azido)ynamides: an Efficient Strategy for the Construction of Indoloquinolines2014
    • Author(s)
      Tokimizu Y, Oishi S Fujii N, Ohno H.
    • Journal Title

      Org. Lett.

      Volume: 16 Pages: 3138-3141

    • DOI

      10.1021/ol5012604

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-24689001

  • [Journal Article] A radiogallium-DOTA-based bivalent peptidic ligand targeting a chemokine receptor, CXCR4, for tumor imaging.2014
    • Author(s)
      Sano K, Masuda R, Hisada H, Oishi S, Shimokawa K, Ono M, Fujii N, Saji H, Mukai T.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 24 Pages: 1386-1388

    • DOI

      10.1016/j.bmcl.2014.01.031

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-23689007

  • [Journal Article] Optimization of diaryl amine derivatives as kinesin spindle protein inhibitors2014
    • Author(s)
      Takeuchi T, Oishi S, Kaneda M, Misu R, Ohno H, Sawada J, Asai A, Nakamura S, Nakanishi I, Fujii N.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 22 Pages: 3171-3179

    • DOI

      10.1016/j.bmc.2014.04.008

    • NAID

      120005466732

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Journal Article] Synthesis of Fused Tetracyclic Spiroindoles via Palladium-Catalysed Cascade Cyclisation2014
    • Author(s)
      Akira Iwata, Shinsuke Inuki, Shinya Oishi, Nobutaka Fujii and Hiroaki Ohno
    • Journal Title

      Chem. Commun

      Volume: 50 Pages: 298-300

    • DOI

      10.1039/c3cc46511j

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J05601, KAKENHI-PROJECT-23390025, KAKENHI-PUBLICLY-24106720, KAKENHI-PROJECT-24689001

  • [Journal Article] Synthesis of IB-01212 by multiple N-methylations of peptide bonds2014
    • Author(s)
      Nabika R, Oishi S, Misu R, Ohno H, Fujii N.
    • Journal Title

      Bioorganic Medicinal Chemistry

      Volume: 22 Pages: 6156-6162

    • DOI

      10.1016/j.bmc.2014.08.036

    • NAID

      120005512275

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-12J06309, KAKENHI-PROJECT-14J07872, KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-24659004

  • [Journal Article] Design and synthesis of fluorescent probes for GPR542014
    • Author(s)
      Kaneda M, Misu R, Ohno H, Hirasawa A, Ieda N, Uenoyama Y, Tsukamura H, Maeda K, Oishi S, Fujii N.
    • Journal Title

      Bioorg Med Chem.

      Volume: 22 Pages: 3325-3330

    • DOI

      10.1016/j.bmc.2014.04.052

    • NAID

      120005466733

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-12J06309, KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-23689007, KAKENHI-PROJECT-26252046

  • [Journal Article] Kinesin spindle protein inhibitors with diaryl amine scaffolds: crystal packing analysis for improved aqueous solubility2014
    • Author(s)
      Takeuchi T, Oishi S, Kaneda M, Ohno H, Nakamura S, Nakanishi I, Yamane M, Sawada J, Asai A, Fujii N.
    • Journal Title

      ACS Med. Chem. Lett.

      Volume: 5 Pages: 566-571

    • DOI

      10.1021/ml500016j

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Journal Article] Characterization of the receptor binding residues of kisspeptins by positional scanning using peptide photoaffinity probes.2013
    • Author(s)
      Misu R, Oishi S, Setsuda S, Noguchi T, Kaneda M, Ohno H, Evans B, Navenot JM, Peiper SC, Fujii N.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 23 Pages: 2628-2631

    • DOI

      10.1016/j.bmcl.2013.02.098

    • NAID

      120005244679

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-12J06309, KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-23689007

  • [Journal Article] Design and synthesis of biotinor alkyne-conjugated photoaffinity probes for studying the target molecules of PD 4041822013
    • Author(s)
      Tsukasa Mizuhara, Shinya Oishi, Hiroaki Ohno, Kazuya Shimura, Masao Matsuoka, Nobutaka Fujii
    • Journal Title

      Bioorg Med Chem

      Volume: 21 Pages: 2079-2087

    • DOI

      10.1016/j.bmc.2013.01.016

    • NAID

      120005244253

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J01895, KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-24791021

  • [Journal Article] Convergent Synthesis of (-)-Quinocarcin Based on the Combination of Sonogashira Coupling and Gold(I)-Catalyzed 6-endo-dig Hydroamination2013
    • Author(s)
      Hiroaki Chiba, Yuki Sakai, Ayako Ohara, Shinya Oishi, Nobutaka Fujii, Hiroaki Ohno
    • Journal Title

      Chem. Eur. J.

      Volume: (in press) Pages: 8875-8883

    • DOI

      10.1002/chem.201300687

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J01905, KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-24689001, KAKENHI-PUBLICLY-24106720

  • [Journal Article] Diversity-Oriented Synthesis of Pyrazolo[4,3-b]indoles by Gold-Catalysed Three-Component Annulation: Application to the Development of a New Class of CK2 Inhibitors2013
    • Author(s)
      Hou Z, Oishi S, Suzuki Y, Kure T, Nakanishi I., Hirasawa A, Tsujimoto G, Ohno H, Fujii N.
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 11 Pages: 3288-3296

    • DOI

      10.1039/c3ob40223a

    • NAID

      120005474525

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-23659038, KAKENHI-PROJECT-24689001, KAKENHI-PUBLICLY-24106720

  • [Journal Article] Structure-activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents2013
    • Author(s)
      Mizuhara T, Kato T, Hirai A, Kurihara H, Shimada Y, Taniguchi M, Maeta M, Togami H, Shimura K, Matsuoka M, Okazaki S, Takeuchi T, Ohno H, Oishi S, Fujii N.
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 23 Pages: 4557-4561

    • DOI

      10.1016/j.bmcl.2013.06.026

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-24791021

  • [Journal Article] Synthesis of Pachastrissamine (Jaspine B) and Its Derivatives by the Late-Stage Introduction of the C-2 Alkyl Side-Chain Using Cross Metathesis2013
    • Author(s)
      Yoshimitsu Y, Miyagaki J, Oishi S, Fujii N, Ohno H.
    • Journal Title

      Tetrahedron

      Volume: 69 Pages: 4211-4220

    • DOI

      10.1016/j.tet.2013.03.091

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-24659046, KAKENHI-PROJECT-24689001, KAKENHI-PUBLICLY-24106720

  • [Journal Article] An optimized method of G-protein coupled receptor homology modeling: its application to the discovery of novel CXCR7 ligands.2013
    • Author(s)
      Yoshikawa Y, Oishi S, Kubo T, Tanahara N, Fujii N, Furuya T.
    • Journal Title

      J. Med. Chem.

      Volume: 56 Pages: 4236-4251

    • DOI

      10.1021/jm400307y

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-23689007

  • [Journal Article] Affinity-based screening of MDM2/MDMXp53 interaction inhibitors by chemical array: identification of novel peptidic inhibitors2013
    • Author(s)
      Noguchi T, Oishi S, Honda K, Kondoh Y, Saito T, Kubo T, Kaneda M, Ohno H, Osada H, Fujii N
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 23 Pages: 3802-3805

    • DOI

      10.1016/j.bmcl.2013.04.094

    • NAID

      120005302102

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23510287, KAKENHI-PROJECT-24659046

  • [Journal Article] Structure-activity relationship study of a CXC chemokine receptor type 4 (CXCR4) antagonist FC131 using a series of alkene dipeptide isosteres2012
    • Author(s)
      Kobayashi K., et al
    • Journal Title

      J. Med. Chem.

      Volume: (in press) Pages: 2746-2757

    • DOI

      10.1021/jm2016914

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J02083, KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-23570192, KAKENHI-PROJECT-23689007

  • [Journal Article] Peptide and peptidomimetic ligands for CXC chemokine receptor 4 (CXCR4)2012
    • Author(s)
      Oishi S, Fujii N.
    • Journal Title

      Org. Biomol. Chem.

      Volume: 10 Pages: 5720-5731

    • DOI

      10.1039/c2ob25107h

    • NAID

      120005243444

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Journal Article] Paradoxical downregulation of CXC chemokine receptor 4 induced by polyphemusin II-derived antagonists2012
    • Author(s)
      Masuda R, Oishi S, Tanahara N, Ohno H, Hirasawa A, Tsujimoto G, Yano Y, Matsuzaki K, Navenot J, Peiper S, Fujii N.
    • Journal Title

      Bioconjugate Chemistry

      Volume: 23 Pages: 1259-1265

    • DOI

      10.1021/bc300084h

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-23659038, KAKENHI-PROJECT-23689007

  • [Journal Article] Structure-Based Design of Novel Potent Protein Kinase CK2 (CK2) Inhibitors with Phenyl-azole Scaffolds2012
    • Author(s)
      Z. Hou, I. Nakanishi, T. Kinoshita, Y. Takei, M. Yasue, R. Misu, Y. Suzuki, S. Nakamura, T. Kure, H. Ohno, K. Murata, K. Kitaura, A. Hirasawa, G. Tsujimoto, S. Oishi, N. Fujii.
    • Journal Title

      Journal of Medicinal Chemistry

      Volume: 55 Pages: 2899-2903

    • DOI

      10.1021/jm2015167

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590110, KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-23659038

  • [Journal Article] Efficient synthesis of aminomethylated azaindoles and corresponding pyrrole-fused derivatives by copper-catalyzed domino multicomponent coupling and cyclization.2012
    • Author(s)
      Hou, Z., Ohno, H., et al
    • Journal Title

      Tetrahedron

      Volume: 68 Pages: 1695-1703

    • DOI

      10.1016/j.tet.2011.12.059

    • NAID

      120003874274

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-22106521, KAKENHI-PROJECT-22590005, KAKENHI-PROJECT-23390025

  • [Journal Article] Development and application of fluorescent SDF-1 derivatives.2012
    • Author(s)
      Masuda R, Oishi S, Tanahara N, Ohno H, Hirasawa A, Tsujimoto G, Kodama E, Matsuoka M, Fujii N.
    • Journal Title

      Future Medicinal Chemistry

      Volume: 4 Pages: 837-844

    • DOI

      10.4155/fmc.12.31

    • NAID

      120005285488

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-23590636, KAKENHI-PROJECT-23659038, KAKENHI-PROJECT-23689007

  • [Journal Article] Concise synthesis and anti-HIV activity of pyrimido [1,2-c][1,3]-benzothiazin-6-imines and related tricyclic heterocycles2012
    • Author(s)
      Mizuhara T, Oishi S, Ohno H, Shimura K, Matsuoka M, Fujii N.
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 10 Pages: 6792-6802

    • DOI

      10.1039/c2ob25904d

    • NAID

      120005302103

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-24791021

  • [Journal Article] Structure-activity relationship study of pyrimido[1, 2-c][1, 3]benzothiazin-6- imine derivatives for potent anti-HIV agents2012
    • Author(s)
      Tsukasa Mizuhara, Shinya Oishi, Hiroaki Ohno, Kazuya Shimura, Masao Matsuoka, Nobutaka Fujii
    • Journal Title

      Bioorg Med Chem

      Volume: 20 Pages: 6434-41

    • DOI

      10.1016/j.bmc.2012.08.030

    • NAID

      120004920439

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J01895, KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-24791021

  • [Journal Article] Non-invasive longitudinal imaging of tumor progression using an 111Indium labeled CXCR4 peptide antagonist.2012
    • Author(s)
      Buckle T, Van den Berg NS, Kuil J, Bunschoten A, Oldenburg J, Borowsky AD, Wesseling J, Masada R, Oishi S, Fujii N, Van Leeuwen FB.
    • Journal Title

      Am. J. Nucl. Med. Mol. Imaging,

      Volume: 2 Pages: 99-109

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Journal Article] Design and synthesis of a novel class of CK2 inhibitors: application of copper- and gold-catalysed cascade reactions for fused nitrogen heterocycles2012
    • Author(s)
      Suzuki Y, Oishi S, Takei Y, Yasue M, Misu R, Naoe S, Hou Z, Kure T, Nakanishi I, Ohno H, Hirasawa A, Tsujimoto G, Fujii N.
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 10 Pages: 4907-4915

    • DOI

      10.1039/c2ob25298h

    • NAID

      120005244966

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J06309, KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-23659038

  • [Journal Article] Molecular modeling study of cyclic pentapeptide CXCR4 antagonists: new insight into CXCR4-FC131 interactions.2012
    • Author(s)
      Kobayashi K., Yoshikawa Y., et al
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 22 Pages: 2146-2150

    • DOI

      10.1016/j.bmcl.2012.01.134

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J02083, KAKENHI-PROJECT-23390025

  • [Journal Article] Gold-catalyzed three-component annulation: efficient synthesis of highly functionalized dihydropyrazoles from alkynes, hydrazines, and aldehydes or ketones.2012
    • Author(s)
      Suzuki, Y., Ohno, H., et al
    • Journal Title

      Org. Lett.

      Volume: 14 Pages: 326-329

    • DOI

      10.1021/ol203072u

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-22106521, KAKENHI-PROJECT-22590005, KAKENHI-PROJECT-23390025

  • [Journal Article] Pachastrissamine (jaspine B) and its stereoisomers inhibit sphingosine kinases and atypical protein kinase C.2011
    • Author(s)
      Yoshimitsu Y.Oishi S.miyagaki J.Inuki S.Ohno H.Fujii N.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 19 Pages: 5402-5408

    • DOI

      10.1016/j.bmc.2011.07.061

    • NAID

      120003386631

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J02576, KAKENHI-PROJECT-23390025

  • [Journal Article] Structure-activity relationships of carboline and carbazole derivatives as a novel class of ATP-competitive kinesin spindle protein inhibitors2011
    • Author(s)
      Takeuchi T, Oishi S, Watanabe T, Ohno H, Sawada J, Matsuno K,Asai A, Asada N, Kitaura K, Fujii N.
    • Journal Title

      J. Med. Chem.

      Volume: 54巻 Pages: 4839-4846

    • DOI

      10.1021/jm200448n

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590067, KAKENHI-PROJECT-23390025

  • [Journal Article] Fluorescent imaging of high grade bladder cancer using a specific antagonist for chemokine receptor CXCR42010
    • Author(s)
      Nishizawa K, Oishi S, Fujii N, et al.
    • Journal Title

      Int.J.Cancer

      Volume: 127 Pages: 1180-1187

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Journal Article] Fluorescent imaging of high grade bladder cancer using a specific antagonist for chemokine receptor CXCR42010
    • Author(s)
      Nishizawa K, Oishi S, Fujii N, et al.
    • Journal Title

      Int.J.Cancer

      Volume: 127 Pages: 1180-1187

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Journal Article] Synthesis and biological evaluation of selective CXCR4 antagonists containing alkene dipeptide isosteres2010
    • Author(s)
      Narumi T, Ohno H, Oishi S, Fujii N, et al.
    • Journal Title

      Org.Biomol.Chem.

      Volume: 8 Pages: 616-621

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Journal Article] Synthesis and biological evaluation of selective CXCR4 antagonists containing alkene dipeptide isosteres2010
    • Author(s)
      Narumi T, Ohno H, Oishi S, Fujii N, et al.
    • Journal Title

      Org.Biomol.Chem.

      Volume: 8 Pages: 616-621

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Journal Article] Chemokine receptor CXCR4 as a therapeutic target for neuroectodermal tumors2009
    • Author(s)
      Hyunsuk S., Oishi S., Fujii N., et.al.
    • Journal Title

      Semin. Cancer Biol 19

      Pages: 123-134

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Journal Article] SDF-1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair2009
    • Author(s)
      Kitaori T., Oishi S., Fujii N., et.al.
    • Journal Title

      Arthritis Rheum 60

      Pages: 813-823

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Journal Article] Amino acid-based synthesis of trifluoromethylalkene dipeptide isosteres by alcohol-assisted nucleophilic trifluoromethylation and organozinc-ccopper-mediated SN2' alkylation2009
    • Author(s)
      Kobayashi K, Oishi S, Ohno H, Fujii N, et al.
    • Journal Title

      J.Org.Chem.

      Volume: 74 Pages: 4626-4629

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Journal Article] Prognostic value of metastin expression in human pancreatic cancer2009
    • Author(s)
      Nagai K, Oishi S, Fujii N, et al.
    • Journal Title

      J.Exp.Clin.Cancer Res.

      Volume: 28 Pages: 9-9

    • NAID

      120004770245

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Journal Article] Structure-activity relationship study on artificial CXCR4 ligands possessing the cyclicpentapeptide scaffold : the exploration of amino acid residues of pentapeptides by substitutions of several aromatic amino acids2009
    • Author(s)
      Tanaka T, Oishi S, Fujii N, et al.
    • Journal Title

      Org.Biomol.Chem

      Volume: 7 Pages: 3805-3809

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Journal Article] Prognostic value of metastin expression in human pancreatic cancer2009
    • Author(s)
      Nagai K, Oishi S, Fujii N, et al.
    • Journal Title

      J.Exp.Clin.Cancer Res.

      Volume: 28 Pages: 9-9

    • NAID

      120004770245

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Journal Article] Targeted disruption of the CXCL12/CXCR4 axis inhibits osteolysis in a murine model of mveloma-associated bone loss2009
    • Author(s)
      Diamond P., Fujii N., et.al.
    • Journal Title

      J. Bone Miner

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Journal Article] Amino acid-based synthesis of trifluoromethylalkene dipeptide isosteres by alcoholassisted nucleophilic trifluoromethylation and organozinc-ccopper-mediated SN2' alkylation2009
    • Author(s)
      Kobayashi K, Oishi S, Ohno H, Fujii N, et al.
    • Journal Title

      J.Org.Chem.

      Volume: 74 Pages: 4626-4629

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Journal Article] SDF-1/CXCR4 signaling is critical for the recruitment of mesenchvmal stem cells to the fracture site during skeletal repair2009
    • Author(s)
      Kitaori T., Oishi S., Fujii N., et.al.
    • Journal Title

      Arthritis Rheum 60

      Pages: 813-823

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Journal Article] Structure-activity relationship study on artificial CXCR4 ligands possessing the cyclic pentapeptide scaffold : the exploration of amino acid residues of pentapeptides by substitutions of several aromatic amino acids2009
    • Author(s)
      Tanaka T, Oishi S, Fujii N, et al.
    • Journal Title

      Org.Biomol.Chem.

      Volume: 7 Pages: 3805-3809

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Journal Article] Targeted disruption of the CXCL12/CXCR4 axis inhibits osteolysis in a murine model of myeloma-associated bone loss2009
    • Author(s)
      Diamond P., Fujii N., et.al.
    • Journal Title

      J. Bone Miner

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Journal Article] Expression of CXCR4, a G-protein-coupled receptor for CXCL12 in yeast identification of new-generation inverse agonists2009
    • Author(s)
      Evans BJ, Oishi S, Fujii N, et al.
    • Journal Title

      Methods Enzymol.

      Volume: 460 Pages: 399-412

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Journal Article] Expression of CXCR4, a G-protein-coupled receptor for CXCL12 in yeast identification of new-generation inverse agonists2009
    • Author(s)
      Evans BJ, Oishi S, Fujii N, et al.
    • Journal Title

      Methods Enzymol.

      Volume: 460 Pages: 399-412

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Journal Article] Chemokine receptor CXCR4 as a therapeutic target for neuroectodermal tumors2009
    • Author(s)
      Hyunsuk S., Oishi S., Fujii N., et.al.
    • Journal Title

      Semin. Cancer Biol 19

      Pages: 123-134

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Journal Article] Clinical significance of plasma metastin level in pancreatic cancer patients2009
    • Author(s)
      Katagiri F, Oishi S, Fujii N, et al.
    • Journal Title

      Oncol.Rep.

      Volume: 21 Pages: 815-819

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Journal Article] Clinical significance of plasma metastin level in pancreatic cancer patients2009
    • Author(s)
      Katagiri F, Oishi S, Fujii N, et al.
    • Journal Title

      Oncol.Rep.

      Volume: 21 Pages: 815-819

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Journal Article] Development of peptide-targeted lipoplexes to CXCR4-expressing rat glioma cells and rat proliferating endothelial cells2008
    • Author(s)
      Driessen W.H., Fujii N., et.al.
    • Journal Title

      Mol. Ther 16

      Pages: 516-524

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Journal Article] Stromal-derived factor 1 signalling regulates radial and tangential migration in the developing cerebral cortex2008
    • Author(s)
      Liapi A., Fujii N., et.al.
    • Journal Title

      Dev. Neurosci 30

      Pages: 117-131

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Journal Article] Structure-activity relationship study of CXCR4 antagonists bearing the cyclic pentapeptide scaffold : identification of the new pharmacophore2008
    • Author(s)
      Tanaka T., Fujii N., et.al.
    • Journal Title

      Org. Biomol. Chem 6

      Pages: 4374-4377

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Journal Article] Direct construction of bicyclic heterocycles by palladium-catalyzed domino cyclization of propargyl bromides.2008
    • Author(s)
      Ohno H., Okano A., Kosaka S., Tsukamoto K., Ohata M., Ishihara K., Maeda H., Tanaka T., Fujii N.
    • Journal Title

      Org. Lett. 10

      Pages: 1171-1174

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Modulation of network-driven, GABA-mediated giant depolarizing potentials by SDF-la in the developing hippocampus2008
    • Author(s)
      Kasiyanov A., Fujii N., et.al.
    • Journal Title

      Dev. Neurosci 30

      Pages: 285-292

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Journal Article] Synthesis of highly functionalized alkene dipeptide isosteres and its application to the structure-activity relationship study on bioactive peptides2008
    • Author(s)
      Oishi S., Fujii N., et.al.
    • Journal Title

      J. Synth. Org. Chem. Jpn 66

      Pages: 846-857

    • NAID

      10024278609

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Journal Article] Efficient synthesis of trifluoromethyl and related trisubstituted alkene dipeptide isosteres by palladium-catalyzed carbonylation of amino acid-derived allylic carbonates.2008
    • Author(s)
      Inokuchi E., Narumi T., Niida A., Kobayashi K., Tomita K., Oishi S., Ohno H., Fujii N.
    • Journal Title

      J. Org. Chem. 73

      Pages: 3942-3945

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Modulation of network-driven, GABA-mediated giant depolarizing potentials by SDF-la in the developing hippocampus2008
    • Author(s)
      Kasiyanov A., Fujii N., et.al.
    • Journal Title

      Dev. Neurosci 30

      Pages: 285-292

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Journal Article] A future perspective on the development of chemokine receptorCXCR4 antagonists2008
    • Author(s)
      Tamamura H., Fujii N., et.al.
    • Journal Title

      Expert Opin. Drug Discov 3

      Pages: 1155-1166

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Journal Article] Facile synthesis of 3-(aminomethyl)isoquinolines by copper-catalysed domino four-component coupling and cyclisation.2008
    • Author(s)
      Ohta Y., Oishi S., Fujii N., Ohno H.
    • Journal Title

      Chem. Commun. 7

      Pages: 835-837

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Efficient synthesis of trifluoromethyl and related trisubstituted alkene dipeptide isosteres by palladium-catalyzed carbonylation of amino acid-derived allylic carbonates2008
    • Author(s)
      Fujii N., Ohno H., Oishi, S., et. al.
    • Journal Title

      J. Org. Chem. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] Stromal-derived factor 1 signalling regulates radial and tangential migration in thedeveloping cerebral cortex2008
    • Author(s)
      Liapi A., Fujii N., et al
    • Journal Title

      Dev. Neurosci 30

      Pages: 117-131

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Journal Article] Diastereoselective synthesis of highly functionalized fluoroalkene dipeptide isosteres and its application to fmoc-based solid phase synthesis of a cyclic pentapeptide mimetic.2008
    • Author(s)
      Narumi T., Tomita K., Inokuchi E., Kobayashi K., Oishi S., Ohno H., Fujii N.
    • Journal Title

      Tetrahedron 64

      Pages: 4332-4346

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Blockade of CXCL12/CXCR4 axis ameliorates murine experimentalcolitis2008
    • Author(s)
      Mikami S., Fujii N., et.al.
    • Journal Title

      J. Pharmacol. Exp. Ther 327

      Pages: 383-392

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Journal Article] Design of a novel HIV-1 fusion inhibitor that displays a minimal interface for binding affinity2008
    • Author(s)
      Fujii N., Ohno H., Oishi, S., et. al.
    • Journal Title

      J. Med. Chem. 51

      Pages: 388-391

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] Synthesis of highly functionalized alkene dipeptide isosteres and its application to thestructure-activity relationship study on bioactive peptides2008
    • Author(s)
      Oishi S., Fujii N., et.al.
    • Journal Title

      J. Synth. Org. Chem. Jpn 66

      Pages: 846-857

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Journal Article] Diastereoselective synthesis of highly functionalized fluoroalkene dipeptide isosteres and its application to Fmoc-based solid phase synthesis of a cyclic pentapeptide mimetic2008
    • Author(s)
      Narumi T., Oishi S., Fujii N., et.al.
    • Journal Title

      Tetrahedron 64

      Pages: 4332-4346

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Journal Article] Palladium-catalyzed sp3 C-H activation of simple alkyl groups: direct preparation of indoline derivatives from N-alkyl-2-bromoanilines2008
    • Author(s)
      Fujii N., Ohno H., Oishi, S., et. al.
    • Journal Title

      Org. Lett. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] Identification of novel nonpeptide CXCR4 antagonists by ligand-baseddesian aporoach2008
    • Author(s)
      Ueda S., Oishi S., Fujii N., et.al.
    • Journal Title

      Bioorg. Med. Chem. Lett 18

      Pages: 4124-4129

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Journal Article] Design of a novel HIV-1fusion inhibitor that displays a minimal interface for binding affinity.2008
    • Author(s)
      Oishi S., Ito S., Nishikawa H., Watanabe K., Tanaka M., Ohno H., Izumi K., Sakagami Y., Kodama E., Matsuoka M., Fujii N.
    • Journal Title

      J. Med. Chem. 51

      Pages: 388-391

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Potent synergistic anti-HIV effects using combinations of a CCR52008
    • Author(s)
      Nakata H., Fujii N., et.al.
    • Journal Title

      Antimicrob. Agents. Chemother 52

      Pages: 2111-2119

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Journal Article] Heptad repeat-derived peptides block protease-mediated direct entry from the cell surface of severe acute respiratory syndrome coronavirus but not entry via the endosomal pathway pathway.2008
    • Author(s)
      Ujike M., Nishikawa H., Otaka A., Yamamoto N., Yamamoto N., Matsuoka M., Kodama E., Fujii N., Taguchi F.
    • Journal Title

      J. Virol. 82

      Pages: 588-592

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Development of peptide-targeted lipoplexes to CXCR4-expressing rat glioma cells and rat proliferating, endothelial cells.2008
    • Author(s)
      Driessen W. H., Fujii N., Tamamura H., Sullivan S. M.
    • Journal Title

      Mol. Ther. 16

      Pages: 516-524

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Efficient synthesis of trifluoromethyl and related trisubstituted alkene dipeptide isosteres bypalladium-catalyzed carbonylation of amino acid-derived Arlie carbonates2008
    • Author(s)
      Inokuchi E., Oishi S., Fujii N., et.al.
    • Journal Title

      J. Org. Chem 73

      Pages: 3942-3945

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Journal Article] Blockade of CXCL12/CXCR4 axis ameliorates murine experimental colitis2008
    • Author(s)
      Mikami S., Fujii N., et.al.
    • Journal Title

      J. Pharmacol. Exp. Ther 327

      Pages: 383-392

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Journal Article] Potent synergistic anti-HIV effects using combinations of a CCR52008
    • Author(s)
      Nakata H., Fujii N., et.al.
    • Journal Title

      Antimicrob. Agents. Chemother 52

      Pages: 2111-2119

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Journal Article] Development of novel GPR54 agonists with resistance to degradation by matrix metalloproteinase2008
    • Author(s)
      Tomita K., Oishi S., Fujii N., et.al.
    • Journal Title

      J. Med. Chem 51

      Pages: 7645-7649

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Journal Article] Identification of novel nonpeptide CXCR4 antagonists by ligand-based design approach2008
    • Author(s)
      Ueda S., Oishi S., Fujii N., et.al.
    • Journal Title

      Bioorg. Med. Chem. Lett 18

      Pages: 4124-4129

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Journal Article] Efficient synthesis of trifluoromethyl and related trisubstituted alkene dipeptide isosteres by palladium-catalyzed carbonylation of amino acid-derived allylic carbonates2008
    • Author(s)
      Inokuchi E., Oishi S., Fujii N., et.al.
    • Journal Title

      J. Org. Chem 73

      Pages: 3942-3945

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Journal Article] Diastereoselective synthesis of highly functionalized fluoroalkene dipeptide isosteres and itsapplication to Fmoc-based solid phase synthesis of a cyclic pentapeptide mimetic2008
    • Author(s)
      Narumi T., Oishi S., Fujii N., et.al.
    • Journal Title

      Tetrahedron 64

      Pages: 4332-4346

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Journal Article] Facile synthesis of 3-(aminomethyl) isoquinolines by copper-catalysed domino four-component coupling and cyclisation2008
    • Author(s)
      Fujii N., Ohno H., Oishi, S., et. al.
    • Journal Title

      Chem. Commun. 7

      Pages: 835-837

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] Direct construction of bicyclic heterocycles by palladium-catalyzed domino cyclization of propargyl bromides2008
    • Author(s)
      Fujii N., Ohno H., et. al.
    • Journal Title

      Org. Lett. 10

      Pages: 1171-1174

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] Diastereoselective synthesis of highly functionalized fluoroalkene dipeptide isosteres and its application to fmoc-based solid phase synthesis of a cyclic pentapeptide mimetic2008
    • Author(s)
      Fujii N., Ohno H., Oishi, S., et. al.
    • Journal Title

      Tetrahedron (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] Structure-activity relationship study of CXCR4 antagonists bearing the cyclic pentapeptide scaffold : identification of the new pharmacophore2008
    • Author(s)
      Tanaka T., Fujii N., et.al.
    • Journal Title

      Org. Biomol. Chem 6

      Pages: 4374-4377

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Journal Article] Palladium-catalyzed sp3 C-H activation of simple alkyl groups: direct preparation of indoline derivatives from N-alkyl-2-bromoanilines.2008
    • Author(s)
      Watanabe T., Oishi S., Fujii N., Ohno H.
    • Journal Title

      Org. Lett. 10

      Pages: 1759-1762

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Development of peptide-targeted lipoplexes to CXCR4-expressing rat glioma cells andrat proliferating endothelial cells2008
    • Author(s)
      Driessen W.H., Fujii N., et.al.
    • Journal Title

      Mol. Ther 16

      Pages: 516-524

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Journal Article] A future perspective on the development of chemokine receptor CXCR4 antagonists2008
    • Author(s)
      Tamamura H., Fujii N., et.al.
    • Journal Title

      Expert Opin. Drug Discov 3

      Pages: 1155-1166

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Journal Article] Synthesis and application of fluorescein- and botin-labeled molecular probes for chemokine receptor CXCR4.2008
    • Author(s)
      Oishi S., Masuda R., Evans B., Ueda S., Goto Y., Ohno H., Hirasawa A., Tsujimoto G., Wang Z., Peiper S. C., Naito T., Kodama E., Matsuoka M., Fujii N.
    • Journal Title

      Chem BioChem 9

      Pages: 1154-1158

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Stromal-derived factor 1 signalling regulates radial and tangential migration in the developing cerebral cortex.2008
    • Author(s)
      Liapi A., Pritchett J., Jones O., Fujii N., Parnavelas J. G., Nadarajah B.
    • Journal Title

      Dev. Neurosci. 30

      Pages: 117-131

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Development of novel GPR54 agonists with resistance to degradation by matrixmetalloproteinase2008
    • Author(s)
      Tomita K., Oishi S., Fujii N., et.al.
    • Journal Title

      J. Med. Chem 51

      Pages: 7645-7649

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Journal Article] Establishment and clinical application of enzyme immunoassays for determination of luteinizing hormone releasing hormone and metastin.2007
    • Author(s)
      Katagiri F., Tomita K., Oishi S., Takeyama M., Fujii N.
    • Journal Title

      J. Pept. Sci. 13

      Pages: 422-429

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Direct synthesis of 2-(aminomethyl)indoles through copper(I)-catalyzed domino three-component coupling and cyclization reactions.2007
    • Author(s)
      Ohno H., Ohta Y., Oishi S., Fujii N.
    • Journal Title

      Angew. Chem. Int. Ed. 46

      Pages: 2295-2298

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Direct Synthesis of 2-(Aminomethyl)indoles through Copper(I)-Catalyzed Domino Three-Component Coupling and Cyclization Reactions.2007
    • Author(s)
      Ohno, H., Oishi, S., Fujii, N.et al.
    • Journal Title

      Angew. Chem. Int. Ed. Engl. 46・13

      Pages: 2295-2298

    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Inhibitors of the chemokine receptor CXCE4 : chemotherapy of AIDS, metastatic cancer, leukemia and rheumatoid arthritis.2007
    • Author(s)
      Tsutsumi H., Tamamura H., Fujii N.
    • Journal Title

      Lett. Drug Design Discov. 4

      Pages: 20-26

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Synthesis of (Z)-alkene-containing cis-proline dipeptide mimetics using samarium(II) diiodide (SmI_2)-mediated reduactive alkylation2007
    • Author(s)
      Sasaki, T., Fujii, N., Otaka, A.et al.
    • Journal Title

      Tetrahedron 63・9

      Pages: 2000-2008

    • Data Source
      KAKENHI-PROJECT-18015027

  • [Journal Article] The therapeutic potential of the chemokine receptor CXCR4 antagonists as multi-functional agents.2007
    • Author(s)
      Tsutsumi H., Tanaka T., Ohashi N., Masuno H., Tamamura H., Hiramatsu K., Araki T., Ueda S., Oishi S., Fujii N.
    • Journal Title

      Biopolymers 88

      Pages: 279-289

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Bromoallenes as allyl dication equivalents in the presence or absence of palladium(O) : direct construction of bicyclic sulfamides containing five-to eight-membered rings by tandem cyclization of bromoallenes.2007
    • Author(s)
      Hamaguchu, H., Ohno, H., Fujii, N., Tanaka, T.et al.
    • Journal Title

      Chem.Eur.J. 13・6

      Pages: 1692-1708

    • Data Source
      KAKENHI-PROJECT-18060020

  • [Journal Article] Development of copper-mediated allylation of y-activated-a, B-unsaturated lactam toward peptide mimetic synthesis.2007
    • Author(s)
      Sasaki Y., Fujii N., Otaka A.
    • Journal Title

      Tetrahedron Lett. 48

      Pages: 3221-3224

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Structureactivity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists : disclosing the importance of side-chain and hackbone2007
    • Author(s)
      Ueda S., Oishi S., Wang Z. X., Araki T., Tamamura H., Cluzeau J., Ohno H. Kusano S., Nakashima H., Trent J. O., Peiper S. C., Fujii N.
    • Journal Title

      J. Med. Chem. 50

      Pages: 192-198

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] One-pot synthesis of carbazoles by palladium-catalyzed N-arylation and oxidative coupling2007
    • Author(s)
      Fujii N., Ohno H., Oishi, S., et. al.
    • Journal Title

      Chem. Commun. 43

      Pages: 4516-4518

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] Development of copper-mediated allylation of γ-activated-α, β-unsaturated lactam toward peptide mimetic synthesis.2007
    • Author(s)
      Sasaki, T., Fujii, N., Otaka, A.et al.
    • Journal Title

      Tetrahedron Lett. 48・18

      Pages: 3221-3224

    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Development of copper-mediated allylation of γ-activated-α,β-unsaturated lactam toward peptide mimetic synthesis.2007
    • Author(s)
      Sasaki, T., Fujii, N., Otaka, A.et al.
    • Journal Title

      Tetrahedron Lett. 48・18

      Pages: 3221-3224

    • Data Source
      KAKENHI-PROJECT-18015027

  • [Journal Article] A Highly Regio- and Stereoselective Formation of Bicyclo[4.2.0]oct-5-ene Derivatives through Thermal Intramolecular [2+2] Cycloaddition2007
    • Author(s)
      Ohno, H., Fujii, N., Tanaka, T.
    • Journal Title

      J.Ore.Chem. (in press)

    • Data Source
      KAKENHI-PROJECT-18015027

  • [Journal Article] Heck-type cyclization of oxime ethers : stereoselective carbon-carbon bond formation with aryl halides to produce heterocyclic oximes.2007
    • Author(s)
      Ohno H., Aso A., Kadoh Y., Fujii N., Tanaka T.
    • Journal Title

      Angew. Chem. Int. Ed. 46

      Pages: 6325-6328

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and Gai activation.2007
    • Author(s)
      Berchiche Y. A., Chow K. Y., Lagane B., Leduc M., Percherancier Y., Fujii N., Tamamura H., Bachelerie F., Heveker N.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 5111-5115

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Design and synthesis of all diastereomers of cyclic pseudo-dipeptides as mimics of cyclic CXCR4 pentapeptide antagonists.2007
    • Author(s)
      Cluzeau J., Oishi S., Ohno H., Wang Z., Evans B., Peiper S. C., Fujii N.
    • Journal Title

      Org. Biomol. Chem. 5

      Pages: 1915-1923

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Development of copper-mediated allylation of γ-activated-α,β-unsaturated lactam toward peptide mimetic synthesis.2007
    • Author(s)
      Sasaki, T., Fujii, N., Otaka, A.et al.
    • Journal Title

      Tetrahedron Lett. 48・18

      Pages: 3221-3224

    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells2007
    • Author(s)
      Kabashima K., Shiraishi N., Sugita K., Mori T., Onoue A., Kobayashi M., Sakabe J., Yoshiki R., Tamamura H., Fujii N., Inaba K., Tokura Y.
    • Journal Title

      Am. J. Pathol. 171

      Pages: 1249-1257

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Versatile use of acid-catalyzed ring-opening of □-aziridinyl-□, □ enoates to stereoselective synthesis of peptidomimetics.2007
    • Author(s)
      Tamamura H., Tanaka T., Tsutsumi H., Nemoto K., Mizokami S., Ohashi N., Oishi S., Fujii N.
    • Journal Title

      Tetrahedron 63

      Pages: 9243-9254

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and G(alpha)(i) activation.2007
    • Author(s)
      Berchiche, Y.A., Fujii, N., Heveker, N.et al.
    • Journal Title

      J.Biol.Chem. 282・8

      Pages: 5111-5115

    • Data Source
      KAKENHI-PROJECT-18015027

  • [Journal Article] Direct Synthesis of 2-(Aminomethyl)indoles through Copper(I)-Catalyzed Domino Three-Component Coupling and Cyclization Reactions.2007
    • Author(s)
      Ohno, H., Fujii, N.et al.
    • Journal Title

      Angew.Chem.Int.Ed.Engl. 46・13

      Pages: 2295-2298

    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] Development of low molecular weight CXCR4 antagonists by exploratory structural tuning of cyclic tetra- and pentapeptide-scaffolds towards the treatment of HIV infection, cancer metastasis and rheumatoid arthritis.2007
    • Author(s)
      Tamamura, H., Fujii, N.et al.
    • Journal Title

      Curr Med Chem 14・1

      Pages: 93-102

    • Data Source
      KAKENHI-PROJECT-18060020

  • [Journal Article] Synthesis of (Z)-alkene-containing cis-proline dipeptide mimetics using samarium(II) diiodide (SmI2)-mediated reduactive alkylation2007
    • Author(s)
      Sasaki, T., Fujii, N., Otaka, A.et al.
    • Journal Title

      Tetrahedron 63・9

      Pages: 2000-2008

    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] A Highly Regio- and Stereoselective Formation of Bicyclo[4.2.0]oct-5-ene Derivatives through Thermal Intramolecular [2 + 2] Cycloaddition of Allenes2007
    • Author(s)
      Ohno, H., Fujii, N., Tanaka, T.
    • Journal Title

      J. Org. Chem. (in press)

    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Synthesis of (Z)-alkene-containing cis-proline dipeptide mimetics using samarium(II) diiodide (SmI_2)-mediated reduactive alkylation2007
    • Author(s)
      Sasaki, T., Fujii, N., Otaka, A.et al.
    • Journal Title

      Tetrahedron 63・9

      Pages: 2000-2008

    • Data Source
      KAKENHI-PROJECT-18060020

  • [Journal Article] Development of low molecular weignt CXCR4 antagonists by exploratory structural tuning of cyclic tetra- and pentapeptide-scaffolds towards the treatment of HIV infection, cancer metastasis and rheumatoid arthritis2007
    • Author(s)
      Tamamura, H., Fujii, N.et al.
    • Journal Title

      Curr Med Chem 14・1

      Pages: 93-102

    • Data Source
      KAKENHI-PROJECT-18015027

  • [Journal Article] CXCR4 antagonists mobilize childhood acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftment.2007
    • Author(s)
      Juarez, J., Fujii, N., Bendall, L.J.et al.
    • Journal Title

      Leukemia (in press)

    • Data Source
      KAKENHI-PROJECT-18060020

  • [Journal Article] Synthesis of (Z)-alkene-containing cis-proline dipeptide mimetics using samarium(II) diiodide (SmI_2)-mediated reduactive alkylation2007
    • Author(s)
      Sasaki, T., Fujii, N., Otaka, A.et al.
    • Journal Title

      Tetrahedron 63・9

      Pages: 2000-2008

    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Fmoc-based solid-phase synthesis of GPR54-agonistic pentapeptide derivatives containing alkene- and fluoroalkene-dipeptide isosteres.2007
    • Author(s)
      Tomita, K., Oishi, S., Fujii, N.et al.
    • Journal Title

      Biopolymers 88・2

      Pages: 272-278

    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Fmoc-based solid-phase synthesis of GPR54-agonistic pentapeptide derivatives containing alkene- and fluoroalkene-dipeptide isosteres.2007
    • Author(s)
      Tomita K., Narumi T., Niida A., Oishi S., Ohno H., Fujii N.
    • Journal Title

      Biopolymers 88

      Pages: 272-278

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Zipper-mode double C-H activation : palladium-catalyzed direct construction of highly-fused heterocyclic systems.2007
    • Author(s)
      Ohno H., Iuchi M., Fujii N., Tanaka T.
    • Journal Title

      Org. Lett. 9

      Pages: 4813-4815

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] SAR and QSAR studies on the N-terminally acylated pentapeptide agonists for GPR54.2007
    • Author(s)
      Tomita K., Oishi S., Cluzeau J., Ohno H., Navenot J. M., Wang Z. X., Peiper S. C., Akamatsu M., Fujii N.
    • Journal Title

      J. Med. Chem. 50

      Pages: 3222-3228

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] A Highly Regio- and Stereoselective Formation of Bicyclo[4.2.0]oct-5-ene Derivatives through Thermal Intramolecular [2+2] Cycloaddition2007
    • Author(s)
      Ohno, H., Fujii, N., Tanaka, T.
    • Journal Title

      J.Org.Chem. (in press)

    • Data Source
      KAKENHI-PROJECT-18060020

  • [Journal Article] Structure-activity relationships of cyclic Peptide-based chemokine receptor CXCR4 antagonists : disclosing the importance of side-chain and backbone functionalities.2007
    • Author(s)
      Ueda, S., Ohno, H., Fujii, N.et al.
    • Journal Title

      J.Med.Chem. 50・2

      Pages: 192-198

    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] Association of nucleophosmin negatively regulates CXCR4-mediated G protein activation and chemotaxis.2007
    • Author(s)
      Zhang W., Navenot J. M., Frilot N. M., Fujii N., Peiper S. C.
    • Journal Title

      Mol. Pharmacol. 72

      Pages: 1310-1321

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] CXCR4 antagonists mobilize childhood acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftment.2007
    • Author(s)
      Juarez, J., Fujii, N., Bendall, L.J.et al.
    • Journal Title

      Leukemia (in press)

    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] Development of copper-mediated allylation of γ-activated-α,β-unsaturated lactam toward peptide mimetic synthesis.2007
    • Author(s)
      Sasaki, T., Fujii, N., Otaka, A.t al.
    • Journal Title

      Tetrahedron Lett. 48・18

      Pages: 3221-3224

    • Data Source
      KAKENHI-PROJECT-18060020

  • [Journal Article] Direct Synthesis of 2-(Aminomethyl)indoles through Copper(I)-Catalyzed Domino Three-Component Coupling and Cyclization Reactions.2007
    • Author(s)
      Ohno, H., Fujii, N.et al.
    • Journal Title

      Angew.Chem.Int.Ed.Engl. 46・13

      Pages: 2295-2298

    • Data Source
      KAKENHI-PROJECT-18015027

  • [Journal Article] CXCR4 engagement promotes dendritic cell survival and maturation.2007
    • Author(s)
      Kabashima K., Sugita K., Shiraishi N., Tamamura H., Fujii N., Tokura Y.
    • Journal Title

      Biochem. Biophys. Kes. Commun. 361

      Pages: 1012-1016

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Systematc solution-phase parallel synthesis of active vitamin D3 analogs with elongated side chains and their cell differentiation activities.2007
    • Author(s)
      Ono Y., Kashiwagi H., Esaki T., Tadakatsu T., Sato H., Fujii N.
    • Journal Title

      J. Comb. Chem. 9

      Pages: 711-716

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Structure-activity relationships of cyclic Peptide-based chemokine receptor CXCR4 antagonists : disclosing the importance of side-chain and backbone functionalities.2007
    • Author(s)
      Ueda, S., Oishi, S., Fujii, N.et al.
    • Journal Title

      J.Med.Chem. 50・2

      Pages: 192-198

    • Data Source
      KAKENHI-PROJECT-18060020

  • [Journal Article] Gold-catalyzed hydroarylation of allenes : a highly regioselective carbon-carbon bond formation producing sixmembered rings.2007
    • Author(s)
      Watanabe T., Oishi S., Fujii N., Ohno H.
    • Journal Title

      Org. Lett. 9

      Pages: 4821-4824

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Bromoallenes as allyl dication equivalents in the presence or absence of palladlum(O) : direct construction of bicyclic sulfamides containing five- to eight-membered rings by tandem cyclization of bromoallenes2007
    • Author(s)
      Hamaguchu, H., Ohno, H., Fujii, N., Tanaka, T.et al.
    • Journal Title

      Chem.Eur.J. 13・6

      Pages: 1692-1708

    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] Structure-activity relationships of cyclic Peptide-based chemokine receptor CXCR4 antagonists : disclosing the importance of side-chain and backbone functionalities.2007
    • Author(s)
      Ueda, S., Ohno, H., Fujii, N.et al.
    • Journal Title

      J.Med.Chem. 50・2

      Pages: 192-198

    • Data Source
      KAKENHI-PROJECT-18015027

  • [Journal Article] Development of low molecular weight CXCR4 antagonists by exploratory structural tuning of cyclic tetra- and pentapeptide-scaffolds towards the treatment of HIV infection, cancer metastasis and rheumatoid arthritis.2007
    • Author(s)
      Tamamura H., Tsutsumi H., Masuno H., Fujii N.
    • Journal Title

      Curr. Med. Chem. 14

      Pages: 93-102

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] SAR and QSAR studies on the N-terminally acylated pentapeptide agonists for GPR542007
    • Author(s)
      Fujii N., Ohno H., Oishi, S., et. al.
    • Journal Title

      J. Med. Chem. 50

      Pages: 3222-3228

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and G(alpha)(i) activation.2007
    • Author(s)
      Berchiche, Y.A., Fujii, N., Heveker, N.et al.
    • Journal Title

      J. Biol. Chem. 282・8

      Pages: 5111-5115

    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and G(alpha)(i) activation.2007
    • Author(s)
      Berchiche, Y.A., Fujii, N., Heveker, N.et al.
    • Journal Title

      J.Biol.Chem. 282・8

      Pages: 5111-5115

    • Data Source
      KAKENHI-PROJECT-18060020

  • [Journal Article] Development of plasmacytoid dendritic cells in bone marrow stromal cell niches requires CXCL12-CXCR4 chemokine signaling.2007
    • Author(s)
      Kohara H., Omatsu Y., Sugiyama T., Noda M., Fujii N., Nagasawa T.
    • Journal Title

      Blood 110

      Pages: 4153-4160

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] A highly regio- and stereoselective formation of bicyclo[4.2.0]oct-5-ene derivatives through thermal intramolecular [2 + 2] cycloaddition of allenes.2007
    • Author(s)
      Ohno H., Mizutani T., Kadoh Y., Aso A., Miyamura K, Fujii N., Tanaka T.
    • Journal Title

      J. Org. Chem. 72

      Pages: 4378-4389

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Facile synthesis of fluoroalkenes by palladium-catalyzed reductive defluorination of allylic gem-difluorides.2007
    • Author(s)
      Narumi T., Tomita K., Inokuchi E., Kobayashi K., Oishi S., Ohno H., Fujii N.
    • Journal Title

      Org. Lett. 9

      Pages: 3465-3468

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Fmoc-based solid-phase synthesis of GPR54-agonistic pentapeptide derivatives containing alkene- and fluoroalkene-dipeptide isosteres.2007
    • Author(s)
      Tomita, K., Oishi, S., Fujii, N.et al.
    • Journal Title

      Biopolymers 88・2

      Pages: 272-278

    • Data Source
      KAKENHI-PROJECT-18060020

  • [Journal Article] Direct Synthesis of 2-(Aminomethyl)indoles through Copper(I)-Catalyzed Domino Three-Component Coupling and Cyclization Reactions.2007
    • Author(s)
      Ohno, H., Oishi, S., Fujii, N.et al.
    • Journal Title

      Angew.Chem.Int.Ed.Engl. 46・13

      Pages: 2295-2298

    • Data Source
      KAKENHI-PROJECT-18060020

  • [Journal Article] Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and G(alpha)(i) activation.2007
    • Author(s)
      Berchiche, Y.A., Fujii, N., Heveker, N.et al.
    • Journal Title

      J.Biol.Chem. 282・8

      Pages: 5111-5115

    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] CXCR4 antagonists mobilize childhood acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftment.2007
    • Author(s)
      Juarez, J., Fujii, N., Bendall, L.J.et al.
    • Journal Title

      Leukemia (in press)

    • Data Source
      KAKENHI-PROJECT-18015027

  • [Journal Article] A Highly Regio- and Stereoselective Formation of Bicyclo[4.2.0]oct-5-ene Derivatives through Thermal Intramolecular [2 + 2] Cycloaddition2007
    • Author(s)
      Ohno, H., Fujii, N., Tanaka, T.
    • Journal Title

      J.Org.Chem. (in press)

    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] One-pot synthesis of carbazoles by palladium-catalyzed N-arylation and oxidative coupling2007
    • Author(s)
      Watanabe T., Ueda S., Inuki S., Oishi S., Fujii N., Ohno H.
    • Journal Title

      Chem. Commun.

      Pages: 4516-4518

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Modulation of networkdriven, GABA-mediated giant depolarizing potentials by SDF-1a in the developing hippocampus.2007
    • Author(s)
      Kasiyanov A., Fujii N., Tamamura H., Xiong H.
    • Journal Title

      Dev. Neurosci. 30

      Pages: 285-292

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Bromoallenes as allyl dication equivalents in the presence or absence of palladium(O) : direct construction of bicyclic sulfamides containing five- to eight-membered rings by tandem cyclization of bromoallenes.2007
    • Author(s)
      Hamaguchi H., Kosaka S., Ohno H., Fujii N., Tanaka T.
    • Journal Title

      Chem-Eur. J. 13

      Pages: 1692-1708

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Fmoc-based solid-phase synthesis of GPR54-agonistic pentapeptide derivatives containing alkene- and fluoroalkene-dipeptide isosteres.2007
    • Author(s)
      Tomita, K., Ohno, H., Fujii, N.et al.
    • Journal Title

      Biopolymers 88・2

      Pages: 272-278

    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] Structure-activity relationships of cyclic Peptide-based chemokine receptor CXCR4 antagonists : disclosing the importance of side-chain and backbone functionalities.2007
    • Author(s)
      Ueda, S., Oishi, S., Fujii, N.et al.
    • Journal Title

      J. Med. Chem. 50・2

      Pages: 192-198

    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Rapid hematopoietic progenitor mobilization by sulfated colominic acid.2007
    • Author(s)
      Kubonishi S., Kikuchi T., Yamaguchi S., Tamamura H., Fujii N., Watanabe T., Arenzana-Seisdedos F., Ikeda K., Matsui T., Tanimoto M., Katayama Y.
    • Journal Title

      Biochem. Biophys. Res. Commun. 355

      Pages: 970-975

    • NAID

      120001384686

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Development of low molecular weight CXCR4 antagonists by exploratory structural tuning or cyclic tetra- and pentapeptide-scaffolds towards the treatment of HIV infection, cancer metastasis and rheumatoid arthritis2007
    • Author(s)
      Tamamura, H., Fujii, N.et al.
    • Journal Title

      Curr Med Chem 14・1

      Pages: 93-102

    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] Zipper-mode double C-H activation: palladium-catalyzed direct construction of highly-fused heterocyclic systems2007
    • Author(s)
      Fujii N., Ohno H., et. al.
    • Journal Title

      Org. Lett. 9

      Pages: 4813-4815

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] A novel oxazolidine linker for the synthesis of peptide aldehydes.2007
    • Author(s)
      Tanaka M., Oishi S., Ohno H., Fujii N.
    • Journal Title

      Int. J. Pep. Res. Ther. 13

      Pages: 271-279

    • NAID

      10020528946

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Fmoc-based solid-phase synthesis of GPR54-agonistic pentapeptide derivatives containing alkene- and fluoroalkene-dipeptide isosteres.2007
    • Author(s)
      Tomita, K., Ohno, H., Fujii, N.et al.
    • Journal Title

      Biopolymers 88・2

      Pages: 272-278

    • Data Source
      KAKENHI-PROJECT-18015027

  • [Journal Article] Bromoallenes as allyl dication equivalents in the presence or absence of palladium(O) : direct construction of bicyclic sulfamides containing five- to eight-membered rings by tandem cyclization of bromoallenes.2007
    • Author(s)
      Hamaguchu, H., Ohno, H., Fujii, N., Tanaka, T.et al.
    • Journal Title

      Chem.Eur.J. 13・6

      Pages: 1692-1708

    • Data Source
      KAKENHI-PROJECT-18015027

  • [Journal Article] Synthesis of (Z)-alkenecontaining cis-proline dipeptide mimetics using samarium (II) diiodide (SmI2)-mediated reductive-alkylation reaction.2007
    • Author(s)
      Sasaki Y., Shigenaga A., Fujii N., Otaka A.
    • Journal Title

      Tetrahedron 63

      Pages: 2000-2008

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Facile synthesis of fluoroalkenes by palladium-catalyzed reductive defluorination of allylic gem-difluorides2007
    • Author(s)
      Fujii N., Ohno H., Oishi, S., et. al.
    • Journal Title

      Org. Lett. 9

      Pages: 3465-3468

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] Development of low molecular weight CXCR4 antagonists by exploratory structural tuning of cyclic tetra- and pentapeptide-scaffolds towards the treatment of HIV infection, cancer metastasis and rheumatoid arthritis.2007
    • Author(s)
      Tamamura, H., Fujii, N.et al.
    • Journal Title

      Curr Med Chem 14・1

      Pages: 93-102

    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] CXCR4 antagonists mobilize childhood acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftment.2007
    • Author(s)
      Juarez, J., Fujii, N., Bendall, L.J.et al.
    • Journal Title

      Leukemia (in press)

    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Heck-type cyclization of oxime ethers: stereoselective carbon-carbon bond formation with aryl halides to produce heterocyclic oximes2007
    • Author(s)
      Fujii N., Ohno H., et. al.
    • Journal Title

      Angew. Chem. Int. Ed. 46

      Pages: 6325-6328

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] Bromoallenes as allyl dication equivalents in the presence or absence of palladium(O) : direct construction of bicyclic sulfamides containing five-to eight-membered rings by tandem cyclization of bromoallenes.2007
    • Author(s)
      Hamaguchu, H., Ohno, H., Fujii, N., Tanaka, T.et al.
    • Journal Title

      Chem. Eur. J. 13・6

      Pages: 1692-1708

    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors.2007
    • Author(s)
      Ogo N., Oishi S., Matsuno K., Sawada J., Fujii N., Asai A.
    • Journal Title

      Bioorg. Med. Chem. Lett. 17

      Pages: 3921-3924

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] CXCR4 antagonists mobilize childhood acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftment.2007
    • Author(s)
      Juarez J., Dela Pena A., Baraz R., Hewson J., Khoo M., Cisterne A., Frickei S., Fujii N., Bradstock K. F., Bendall L. J.
    • Journal Title

      Leukemia 21

      Pages: 1249-1257

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Identification of a new class of low molecular weight antagonists against the chemokine receptor CXCR4 having the dipicolylamine-zinc(II) complex structure.2006
    • Author(s)
      Tamamura, H., Fujii, N.et al.
    • Journal Title

      J. Med. Chem. 49・11

      Pages: 3412-3415

    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Structure-activity relationship study on small peptidic GPR54 agonists.2006
    • Author(s)
      Tomita, K., Ohno, H., Fujii, N.et al.
    • Journal Title

      Bioorg.Med.Chem. 45・22

      Pages: 7595-7603

    • Data Source
      KAKENHI-PROJECT-18015027

  • [Journal Article] The chemokine receptor CXCR4 as a therapeutic target for several disease.2006
    • Author(s)
      Tamamura, H., Tsutsumi, H., Fujii, N.
    • Journal Title

      Mini.Rev.Med.Chem. 6・9

      Pages: 989-995

    • Data Source
      KAKENHI-PROJECT-18015027

  • [Journal Article] Stereoselective synthesis of (Z)-alkene-containing proline dipeptide mimetics2006
    • Author(s)
      Sasaki, T., Fujii, N., Otaka, A.et al.
    • Journal Title

      J.Org.Chem. 71・13

      Pages: 4969-4979

    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases2006
    • Author(s)
      Tamamura H, Tsutumi A, Fujii N
    • Journal Title

      Mini-Reviews in Medicinal Chemistry 6

      Pages: 109-120

    • Data Source
      KAKENHI-PROJECT-16659029

  • [Journal Article] Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs.2006
    • Author(s)
      Tamamura H., Tsutsumi H., Masuno H., Mizokami S., Hiramatsu K., Wang Z., Trent J. O., Nakashima H., Yamamoto N., Peiper S. C., Fujii N.
    • Journal Title

      Org. Biomol. Chem. 4

      Pages: 2354-2357

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs.2006
    • Author(s)
      Tamamura, H., Fujii, N.et al.
    • Journal Title

      Org.Biomol.Chem. 4・12

      Pages: 2354-2357

    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] A novel one-pot reaction involving organocopper-mediated reduction/transmetalation/asymmetric alkylation, leading to the diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres2006
    • Author(s)
      Narumi, T., Ohno, H., Fujii, N.et al.
    • Journal Title

      Chem.Commun. 45

      Pages: 4720-2722

    • Data Source
      KAKENHI-PROJECT-18015027

  • [Journal Article] Therapeutic potential of the chemokine receptor CXCR4 antagonists as multifunctional agents.2006
    • Author(s)
      Tsutsumi H, Fujii N. et al.
    • Journal Title

      Biopolymers 88・2

      Pages: 279-289

    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Stereoselective synthesis of (Z)-alkene-containing proline dipeptide mimetics2006
    • Author(s)
      Sasaki, T., Fujii, N., Otaka, A.et al.
    • Journal Title

      J. Org. Chem. 71・13

      Pages: 4969-4979

    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Stereoselective synthesis of (Z)-alkene-containing proline dipeptide mimetics2006
    • Author(s)
      Sasaki, T., Fujii, N., Otaka, A.et al.
    • Journal Title

      J.Org.Chem. 71・13

      Pages: 4969-4979

    • Data Source
      KAKENHI-PROJECT-18015027

  • [Journal Article] Structure-activity relationship study on small peptidic GPR54 agonists.2006
    • Author(s)
      Tomita K., Niida A., Oishi S., Ohno H., Cluzeau J., Navenot J. M., Wang Z. X., Peiper S. C., Fujii N.
    • Journal Title

      Bioorg. Med. Chem. 14

      Pages: 7595-7603

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Structure-activity relationship study on small peptidic GPR54 agonists.2006
    • Author(s)
      Tomita, K., Oishi, S., Fujii, N.et al.
    • Journal Title

      Bioorg. Med. Chem. 45・22

      Pages: 7595-7603

    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Synthesis of (Z)-alkene and (E)-fluoroalkene-containing diketopiperazine mimetics utili-zing organocopper-mediated reduction-alkylation and diastereoselectivity examination using DFT calculations.2006
    • Author(s)
      Niida, A., Oishi, S., Fujii, N.et al.
    • Journal Title

      J. Org. Chem. 71・11

      Pages: 4118-4129

    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] The chemokine receptor CXCR4 as a therapeutic target for several diseases.2006
    • Author(s)
      Tamamura, H., Tsutsumi, H., Fujii, N.
    • Journal Title

      Mini.Rev.Med.Chem. 6・9

      Pages: 989-995

    • Data Source
      KAKENHI-PROJECT-18060020

  • [Journal Article] A novel one-pot reaction involving organocopper-mediated reduction/transmetalation/asymmetric alkylation, leading to the diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres.2006
    • Author(s)
      Narumi T., Niida A., Tomita K., Oishi S., Otaka A., Ohno H., Fujii N.
    • Journal Title

      Chem. Commun.

      Pages: 4720-4722

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] The chemokine receptor CXCR4 as a therapeutic target for several diseases.2006
    • Author(s)
      Tamamura, H., Tsutsumi, H., Fujii, N.
    • Journal Title

      Mini.Rev.Med.Chem. 6・9

      Pages: 989-995

    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] Application of tri- and tetrasubstituted alkene dipeptide mimetics to conformational studies of cyclic RGD peptides2006
    • Author(s)
      Oishi S., Miyamoto K., Niida A., Yamamoto M., Ajito K., Tamamura H., Otaka A., Kuroda Y., Asai A., Fujii N.
    • Journal Title

      Tetrahedron 62

      Pages: 1416-1424

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] The involvement of stromal derived factor la in homing and progression of multiple myeloma in the 5TMM model.2006
    • Author(s)
      Menu E., Asosingh K., Indraccolo S., De Raeve H., Van Riet I., Van Valckenborgh E., Van de Broek I, Fujii N., Tamamura H., Van Camp B., Vanderkerken K.
    • Journal Title

      Haematologica 91

      Pages: 605-612

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] HIV-1 gpl20 enhances giant depolarizing potentials via chemokine receptor CXCR4 in neonatal rathippocampus.2006
    • Author(s)
      Kasyanov A., Tamamura H., Fujii N., Xiong H.
    • Journal Title

      Eur. J. Neurosci. 23

      Pages: 1120-1128

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Transport characteristics of a novel PEPT1 substrate, antihypotensive drug midodrine, and its amino acid derivatives.2006
    • Author(s)
      Tsuda M., Terada T., Me M., Katsura T., Niida A., Tomita K., Fujii N., Inui K.
    • Journal Title

      J. Pharmacol. Exp. Ther. 318

      Pages: 455-460

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Unequivocal synthesis of (Z)-alkene and (E)-fluoroalkene dipeptide isosteres to probe structural requirements of the peptide transporter PEPT1.2006
    • Author(s)
      Niida A., Tomita K., Mizumoto M., Tanigaki H., Terada T., Oishi S., Otaka A., Inui K., Fujii N.
    • Journal Title

      Org. Lett. 8

      Pages: 613-616

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Structure-activity relationship study on small peptidic GPR54 agonists.2006
    • Author(s)
      Tomita, K., Ohno, H., Fujii, N.et al.
    • Journal Title

      Bioorg.Med.Chem. 45・22

      Pages: 7595-7603

    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs.2006
    • Author(s)
      Tamamura, H., Fujii, N.et al.
    • Journal Title

      Org.Biomol.Chem. 4・12

      Pages: 2354-2357

    • Data Source
      KAKENHI-PROJECT-18015027

  • [Journal Article] Synthesis of (Z)-alkene and (E)- fluoroalkene-containing diketopiperazine mimetics utili-zing organocopper-mediated reduction-alkylation and diastereoselectivity examination using DFT calculations2006
    • Author(s)
      Niida, A., Ohno, H., Fujii, N.et al.
    • Journal Title

      J.Org.Chem. 71・11

      Pages: 4118-4129

    • Data Source
      KAKENHI-PROJECT-18015027

  • [Journal Article] Identification of a new class of low molecular weight antagonists against the chemokine receptor CXCR4 having the dipicolylamine-zinc(II) complex structure.2006
    • Author(s)
      Tamamura, H., Fujii, N.et al.
    • Journal Title

      J.Med.Chem. 49・11

      Pages: 3412-3415

    • Data Source
      KAKENHI-PROJECT-18060020

  • [Journal Article] Syntnesis of (Z)-alkene and (E)-fluoroalkene-containing diketoplperazine mimetics utin-zing organocopper-mediated reduction-alkylation and diastereoselectivity examination using DFT calculations2006
    • Author(s)
      Niida, A., Ohno, H., Fujii, N.et al.
    • Journal Title

      J.Org.Chem. 71・11

      Pages: 4118-4129

    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] Structure-activity relationship study on small peptidic GPR54 agonists.2006
    • Author(s)
      Tomita, K., Oishi, S., Fujii, N.et al.
    • Journal Title

      Bioorg.Med.Chem. 45・22

      Pages: 7595-7603

    • Data Source
      KAKENHI-PROJECT-18060020

  • [Journal Article] Therapeutic potential of the chemokine receptor CXCR4 antagonists as multifunctional agents.2006
    • Author(s)
      Tsutsumi H, Fujii N. et al.
    • Journal Title

      Biopolymers 88・2

      Pages: 279-289

    • Data Source
      KAKENHI-PROJECT-18060020

  • [Journal Article] Synthesis of (Z)-alkene and (E)-fluoroalkenecontaining diketopiperazine mimetics utilizing organocopper-mediated reduction-alkylation and diastereoselectivity examination using DFT2006
    • Author(s)
      Niida A., Mizumoto M., Narumi T., Inokuchi E., Oishi S., Ohno H., Otaka A., Kitaura K., Fujii N.
    • Journal Title

      J. Org. Chem. 71

      Pages: 4118-4129

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Identification of a new class of low molecular weight antagonists against the chemokine receptor CXCR4 having the dipicolylamine-zinc(II) complex structure.2006
    • Author(s)
      Tamamura, H., Fujii, N.et al.
    • Journal Title

      J.Med.Chem. 49・11

      Pages: 3412-3415

    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] Therapeutic potential of the chemokine receptor CXCR4 antagonists as multifunctional agents.2006
    • Author(s)
      Tsutsumi H, Fujii N. et al.
    • Journal Title

      Biopolymers 88・2

      Pages: 279-289

    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] The chemokine receptor CXCR4 as atherapeutic target for several diseases.2006
    • Author(s)
      Tamamura H., Tstsumi H., Fujii N.
    • Journal Title

      Mini Rev. Med. Chem. 6

      Pages: 989-995

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] A-nover one-pot reaction involving orgamcopper-mediated reduction/transmealation/asymmetric alkylation, leading to the diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres2006
    • Author(s)
      Narumi, T., Ohno, H., Fujii, N.et al.
    • Journal Title

      Chem.Commun. 45

      Pages: 4720-2722

    • Data Source
      KAKENHI-PROJECT-18659027

  • [Journal Article] The chemokine receptor CXCR4 as a therapeutic target for several diseases.2006
    • Author(s)
      Tamamura, H., Tsutsumi, H., Fujii, N.
    • Journal Title

      Mini. Rev. Med. Chem. 6・9

      Pages: 989-995

    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Identification of a new class of low molecular weight antagonists against the chemokine receptor CXCR4 having the dipicolylamine-zinc(II) complex structure.2006
    • Author(s)
      Tamamura, H., Fujii, N.et al.
    • Journal Title

      J.Med.Chem. 49・11

      Pages: 3412-3415

    • Data Source
      KAKENHI-PROJECT-18015027

  • [Journal Article] Identification of a new class of low molecular weight antagonists against the chemokine receptor CXCR4 having the dipicolylamine-zinc(II) complex structure.2006
    • Author(s)
      Tamamura H., Ojida A., Ogawa T., Tsutsumi H., Masuno H., Nakashima H., Yamamoto N., Hamachi I., Fujii N.
    • Journal Title

      J. Med. Chem. 49

      Pages: 3412-3415

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] A novel one-pot reaction involving organocopper-mediated reduction/transmetalation/asymmetric alkylation, leading to the diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres.2006
    • Author(s)
      Narumi, T., Oishi, S., Fujii, N.et al.
    • Journal Title

      Chem. Commun. 45

      Pages: 4720-2722

    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Development of a lllln-labeled peptide derivative targeting a chemokine receptor, CXCR4, for imaging tumors.2006
    • Author(s)
      Hanaoka H., Mukai T., Tamamura H., Mori T., Ishino S., Ogawa K., Iida Y., Doi R., Fujii N., Saji H.
    • Journal Title

      Nucl. Med. Biol. 33

      Pages: 489-494

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Stereoselective synthesis of (Z)-alkene-containing proline dipeptide mimetics2006
    • Author(s)
      Sasaki Y., Niida A., Tsuji T., Shigenaga A., Fujii N., Otaka A.
    • Journal Title

      J. Org. Chem. 71

      Pages: 4969-49679

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] A novel one-pot reaction involving organocopper-mediated reduction/transmetalation/asymmetric alkylation, leading to the diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres.2006
    • Author(s)
      Narumi, T., Oishi, S., Fujii, N.et al.
    • Journal Title

      Chem.Commun. 45

      Pages: 4720-4722

    • Data Source
      KAKENHI-PROJECT-18060020

  • [Journal Article] Therapeutic potential of the chemokine receptor CXCR4 antagonists as multifunctional agents.2006
    • Author(s)
      Tsutsumi H, Fujii N. et al.
    • Journal Title

      Biopolymers 88・2

      Pages: 279-289

    • Data Source
      KAKENHI-PROJECT-18015027

  • [Journal Article] Stereoselective synthesis of (Z)-alkene-containing proline dipeptide mimetics2006
    • Author(s)
      Sasaki, T., Fujii, N., Otaka, A.et al.
    • Journal Title

      J.Org.Chem. 71・13

      Pages: 4969-4979

    • Data Source
      KAKENHI-PROJECT-18060020

  • [Journal Article] Cysteinederived S-protected oxazolidinones: potential chemical devices for the preparation of peptide thioesters.2006
    • Author(s)
      Ohta Y., Itoh S., Shigenaga A., Shintaku S., Fujii N., Otaka A.
    • Journal Title

      Org. Lett. 8

      Pages: 467-470

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs.2006
    • Author(s)
      Tamamura, H., Fujii, N.et al.
    • Journal Title

      Org. Biomol. Chem. 4・12

      Pages: 2354-2357

    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Design and synthesis of downsized metastin (45-54) analogs with maintenance of high GPR54 agonistic activity2006
    • Author(s)
      Niida A., Wang Z., Tomita K, Oishi S., Tamamura H., Otaka A., Navenot J. M., Broach J. R., Peiper S. C., Fujii N.
    • Journal Title

      Bioorg. Med. Chem. Lett. 16

      Pages: 134-137

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Development of antiviral fusion inhibiting peptides.2006
    • Author(s)
      Otaka A., Fujii N.
    • Journal Title

      Kagaku Kogyo 57

      Pages: 797-801

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Potassium carbonate-promoted stereospecific 5-endo-trig cyclization of unactivated allenes in the absence of any transition metals.2006
    • Author(s)
      Ohno H., Kadoh Y., Fujii N., Tanaka T.
    • Journal Title

      Org. Lett. 8

      Pages: 947-950

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Stereoselective synthesis of 3,6-disubstituted-3,6-dihydropyridin-2-ones as potential diketopiperazine mimetics using organocopper-mediated anti-SN2' reactions and their use in the preparation of low-molecule CXCR4 antagonists.2006
    • Author(s)
      Niida A., Tanigaki H., Inokuchi E., Sasaki Y., Oishi S., Ohno H., Tamamura H., Wang Z., Peiper S. C., Kitaura K., Otaka A., Fujii N.
    • Journal Title

      J. Org. Chem. 71

      Pages: 3942-3951

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Synthesis of (Z)-alkene and (E)- fluoroalkene-containing diketopiperazine mimetics utili-zing organocopper-mediated reduction-alkylation and diastereoselectivity examination using DFT calculations.2006
    • Author(s)
      Niida, A., Oishi, S., Fujii, N.et al.
    • Journal Title

      J.Org.Chem. 71・11

      Pages: 4118-4129

    • Data Source
      KAKENHI-PROJECT-18060020

  • [Journal Article] Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs.2006
    • Author(s)
      Tamamura, H., Fujii, N.et al.
    • Journal Title

      Org.Biomol.Chem. 4・12

      Pages: 2354-2357

    • Data Source
      KAKENHI-PROJECT-18060020

  • [Journal Article] Structure-activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds.2005
    • Author(s)
      Tamamura H., Esaka A., Ogawa T., Araki T., Ueda S., Wang Z., Trent J. O., Tsutsumi H., Masuno H., Nakashima H., Yamamoto N., Peiper S. C., Otaka A., Fujii N.
    • Journal Title

      Org. Biomol. Chem. 3

      Pages: 4392-4394

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] The therapeutic potential of CXCR4 antagonists in the treatment of HIV infection, cancer metastasis and rheumatoid arthritis.2005
    • Author(s)
      Tamamura H, Fujii N
    • Journal Title

      Expert Opin Ther Targets 9

      Pages: 1267-1282

    • Data Source
      KAKENHI-PROJECT-16659029

  • [Journal Article] Innovative platform for drug discovery based on chemical proteomics: from knowledge to controlling.2005
    • Author(s)
      Fujii N., Otaka A., Tamamura H.
    • Journal Title

      Saibo Kogaku 24

      Pages: 1181-1186

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Photolabile protection for one-pot sequential native chemical ligation.2005
    • Author(s)
      Ueda S., Pujita M., Tamamura H., Fujii N., Otaka A.
    • Journal Title

      ChemBioChem 6

      Pages: 1983-1986

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] New HIV-drug inhibits in vitro bladder cancer migration and invasion.2005
    • Author(s)
      Retz M., Sidhu S. S., Lehmann J., Tamamura H., Fujii N., Basbaum C.
    • Journal Title

      Eur. Urol. 48

      Pages: 1025-1030

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice : implications for CXCL12/CXCR4 axis in lymphoma generation.2005
    • Author(s)
      E.Piovan H.Tamamura, N.Fujii, et al.
    • Journal Title

      Blood 105

      Pages: 931-939

    • Data Source
      KAKENHI-PROJECT-16023235

  • [Journal Article] Stereoselective Synthesis of [L-Arg, L/D-3-(2-naphthyl)alanine]-Type (E)-Alkene Dipeptide Isosteres and its Application to the Synthesis and Biological Evaluation of Pseudopeptide Analogs of the CXCR4 Antagonist FC131.2005
    • Author(s)
      H.Tamamura, N.Fujii, S.C.Peiper et al.
    • Journal Title

      J.Med.Chem. 48

      Pages: 380-391

    • Data Source
      KAKENHI-PROJECT-16023235

  • [Journal Article] Kisspeptin-10induced signaling of GPR54 negatively regulates chemotactic responses mediated by CXCR4: a potential mechanism for the metastasis suppressor activity of kisspeptins.2005
    • Author(s)
      Navenot J. M., Wang Z., Chopin M., Fujii N., Peiper S. C.
    • Journal Title

      Cancer Res. 65

      Pages: 10450-10456

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Stereoselective Synthesis of [L-Arg, L/D-3-(2-naphthyl)alanine]-Type(E)-Alkene Dipeptide Isosteres and its Application to the Synthesis and Biological Evaluation of Pseudopeptide Analogs of the CXCR4 Antagonist FC131.2005
    • Author(s)
      H.Tamamura, N.Fujii, et al.
    • Journal Title

      J.Med.Chem. 48

      Pages: 380-391

    • Data Source
      KAKENHI-PROJECT-16659029

  • [Journal Article] Mutations Conferring Resistance to Human Immunodeficiency Virus Type 1 Fusion Inhibitors Are Restricted by gp41 and Rev-Responsive Element Functions.2005
    • Author(s)
      D.Nameki, M.Matsuoka, N.Fujii, et al.
    • Journal Title

      J.Virology 79

      Pages: 764-770

    • Data Source
      KAKENHI-PROJECT-16659029

  • [Journal Article] The therapeutic potential of CXCR4 antagonists in the treatment of HIV infection, cancer metastasis and rheumatoid arthritis2005
    • Author(s)
      Tamamura H., Fujii N.
    • Journal Title

      Exp. Opin. Ther. Target 9

      Pages: 1267-1282

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Development of anti-HIV agents targeting dynamic supramolecular mechanism : entry and fusion inhibitors based on CXCR4/CCR5 antagonists and gp41-C34-remodeling peptides.2005
    • Author(s)
      Tamamura H, Otaka A, Fujii N.
    • Journal Title

      Curr HIV Res 3

      Pages: 289-301

    • Data Source
      KAKENHI-PROJECT-16659029

  • [Journal Article] Germinal Center Dark and Light Zone Organization Is Mediated by CXCR4 and CXCR5.2004
    • Author(s)
      C.D.C.Allen, H.Tamamura, N.Fujii, J.G.Cyster, et al.
    • Journal Title

      Nature Immunol. 5

      Pages: 943-952

    • Data Source
      KAKENHI-PROJECT-16023235

  • [Journal Article] Identification of a CXCR4 Antagonist, a T140 Analog, as an Anti-rheumatoid Arthritis Agent.2004
    • Author(s)
      H.Tamamura, N.Fujii, et al.
    • Journal Title

      FEBS Lett. 569・1

      Pages: 99-104

    • Data Source
      KAKENHI-PROJECT-14207099

  • [Journal Article] SmI2-mediated Reduction of γ,γ-Difluoro-_α,β-enoates and Its Application to the Synthesis of (Z)-Fluoroalkene-type Dipeptide Isosteres2004
    • Author(s)
      A.Otaka, J.Watanabe, N.Fujii, et al.
    • Journal Title

      J.Org.Chem. 69

      Pages: 1634-1645

    • Data Source
      KAKENHI-PROJECT-14207099

  • [Journal Article] Facile Synthesis of Membrane-embedded Peptides Utilizing Lipid Bilayer-assisted Chemical Ligation.2004
    • Author(s)
      A.Otaka, S.Ueda, N.Fujii, et al.
    • Journal Title

      Chem.Commun. 7

      Pages: 1722-1723

    • Data Source
      KAKENHI-PROJECT-14207099

  • [Journal Article] HIV protease inhibitor, nelfinavir, inhibits replication of SARS-associted coronavirus.2004
    • Author(s)
      N.Yamamoto, N.Fujii, et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 318

      Pages: 719-725

    • Data Source
      KAKENHI-PROJECT-16659029

  • [Journal Article] Two Orthogonal Approaches to Overcome Multi-Drug Resistant HIV-ls : Development of Protease Inhibitors and Entry Inhibitors Based on CXCR4 Antagonists.2004
    • Author(s)
      H.Tamamura, N.Fujii
    • Journal Title

      Curr.Drug Targets-Infectious Disorders 4・2

      Pages: 103-110

    • Data Source
      KAKENHI-PROJECT-16659029

  • [Journal Article] CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer.2004
    • Author(s)
      T.Mori, R.Doi, N.Fujii, et al.
    • Journal Title

      Molecular Cancer Therapeutics 3

      Pages: 29-37

    • Data Source
      KAKENHI-PROJECT-16023235

  • [Journal Article] Germinal Center Dark and Light Zone Organization Is Mediated by CXCR4 and CXCR5.2004
    • Author(s)
      C.D.C.Allen, H.Tamamura, N.Fujii, J.G.Cyster, et al.
    • Journal Title

      Nature Immunol. 5

      Pages: 943-952

    • Data Source
      KAKENHI-PROJECT-14207099

  • [Journal Article] A Single Treatment with Microcapsules Containing a CXCR4 Antagonist Suppresses Pulmonary Metastasis of Murine Melanoma.2004
    • Author(s)
      M.Takenaga, H.Tamamura, N.Fujii, et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 320・1

      Pages: 226-232

    • Data Source
      KAKENHI-PROJECT-16023235

  • [Journal Article] Synthesis of Fluorine-Containing Bioisosteres Corresponding to Phosphoamino Acids and Dipeptide Units2004
    • Author(s)
      A.Otaka, E.Mitsuyama, N.Fujii, et al.
    • Journal Title

      Biopolymers 76

      Pages: 140-149

    • Data Source
      KAKENHI-PROJECT-14207099

  • [Journal Article] Germinal Center Dark and Light Zone Organization Is Mediated by CXCR4 and CXCR5.2004
    • Author(s)
      C.D.C.Allen, H.Tamamura, N.Fujii, J.G.Cyster, et al.
    • Journal Title

      Nat.Immunol. 5

      Pages: 943-952

    • Data Source
      KAKENHI-PROJECT-16659029

  • [Journal Article] Topochemical Exploration of Potent Compounds Using Retro-Enantiomer Libraries of Cyclic Pentapeptides.2004
    • Author(s)
      H.Tamamura, N.Fujii, et al.
    • Journal Title

      Org.Biomol.Chem. 2

      Pages: 1255-1257

    • Data Source
      KAKENHI-PROJECT-14207099

  • [Journal Article] Functional Expression of CXCR4 in Scerevisiae : Development of Tools for Mechanistic and Pharmacologic Studies.2004
    • Author(s)
      H.Zhang, H.Tamamura, N.Fujii, S.C.Peier et al.
    • Journal Title

      Chemokine Roles in Immunoregulation and Disease 45

      Pages: 125-152

    • Data Source
      KAKENHI-PROJECT-16023235

  • [Journal Article] Indium-modiated Atom-transfer and Reductive Radical Cyclizations of Iodoalkynes : Synthesis and Biological Evaluation of HIV-Protease Inhibitors.2004
    • Author(s)
      R.Yanada, Y.Takemoto, H.Mitsuya, N.Fujii, et al.
    • Journal Title

      J.Org.Chem., 69

      Pages: 2417-2422

    • Data Source
      KAKENHI-PROJECT-16659029

  • [Journal Article] The Therapeutic Potential of CXCR4 Antagonists in the Treatment of HIV.2003
    • Author(s)
      N.Fujii, et al.
    • Journal Title

      Expert Opinion on Investigational Drugs 12

      Pages: 185-195

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207099

  • [Journal Article] Molecular Size Reduction of a Potent CXCR4-Chemokimne Antagonists Using Orthogona Combination of Conformation-based and Sequence-based Libraries.2003
    • Author(s)
      N.Fujii, et al.
    • Journal Title

      Angew.Chem.Int Ed.Engl. 42(28)

      Pages: 3251-3253

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207099

  • [Journal Article] The Therapeutic Potential of CXCR4 Antagonists in the Treatment of HIV.2003
    • Author(s)
      N.Fujii, et al.
    • Journal Title

      Expert Opinion on Investigational Drugs 12(2)

      Pages: 185-195

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207099

  • [Journal Article] Molecular Size Reduction of a Potent CXCR4-Chemokimne Antagonists Using Orthogona Combination of Conformation-based and Sequence-based Libraries.2003
    • Author(s)
      N.Fujii, et al.
    • Journal Title

      Angew.Chem.Int Ed.Engl. 42

      Pages: 3251-3253

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207099

  • [Journal Article] Coiled-coil tag-probe system for quick labeling of membrane receptors in living cells.
    • Author(s)
      Yano Y., Yano A., Oishi S., Sugimoto Y., Tsujimoto G., Fujii N., Matsuzaki K.
    • Journal Title

      ACS Chem. Biol. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Identification of novel nonpeptide CXCR4 antagonists by ligand-based design approach.
    • Author(s)
      Ueda S., Kato M., Inuki S., Ohno H., Evans B., Wang Z., Peiper S. C., Izumi K., Kodama E., Matsuoka M., Nagasawa H., Oishi S., Fujii N.
    • Journal Title

      Bioorg. Med. Chem. Lett. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Novel screening systems for HIV-1 fusion mediated by two extra-virion heptad repeats of gp41.
    • Author(s)
      Nishikawa H., Kodama E., Sakakibara A., Fukudome A., Izumi K., Oishi S., Fujii N., Matsuoka M.
    • Journal Title

      Antivir. Res. (in press)

    • NAID

      120002790066

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Structure-activity relationship of pyrazine-based CK2 inhibitors : synthesis and biological evaluation of 2,6-disubstituted pyrazine and 4,6-disubstituted pyrimidine derivatives.
    • Author(s)
      Suzuki Y., Cluzeau J., Hara T., Hirasawa A.. Tsujimoto G., Oishi S., Ohno H., Fujii N.
    • Journal Title

      Archiv. Pharm. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Palladiumcatalysed biscyclisation of allenic bromoalkenes through zipper-mode cascade.
    • Author(s)
      Okano A., Mizutani T., Oishi S., Tanaka T., Ohno H., Fujii N.
    • Journal Title

      Chem. Commun. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Structure-activity relationship study and NMR analysis of fluorobenzoyl pentapeptide GPR54 agonists.
    • Author(s)
      Tomita K., Oishi S., Ohno H., Fujii N.
    • Journal Title

      Biopolymers (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Journal Article] Potent synergistic anti-HIV effects using combinations of a CCR5. inhibitor aplaviroc with other anti-HIV drugs.
    • Author(s)
      Nakata H., Steinberg S. M., Koh Y., Maeda K., Takaoka Y, Tamamura H., Fujii N., Mitsuya H.
    • Journal Title

      Antimicroh. Agents. Chemother. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] 新規KSP阻害薬のヒト乳癌細胞に対する効果2018
    • Author(s)
      太田有紀、土屋聖子、武永美津子、新美純、渡邉大輝、大滝正訓、大石真也、藤井信孝、津川浩一郎、松本直樹
    • Organizer
      第138年会日本薬学会
    • Data Source
      KAKENHI-PROJECT-15K10074

  • [Presentation] ケモカイン受容体CXCR7選択的リガンドの構造最適化研究2017
    • Author(s)
      関口遼、黒柳友子、小林由佳、藤井信孝、大野浩章、大石真也
    • Organizer
      日本薬学会第137回年会
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Presentation] CXCR7受容体選択的リガンドの構造活性相関研究2017
    • Author(s)
      関口遼、黒柳友子、小林由佳、小林数也、赤路健一、藤井信孝、大野浩章、大石真也
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Presentation] Development of novel NK3 receptor antagonists with reduced environmental impact2017
    • Author(s)
      Koki Yamamoto, Hiroaki Ohno, Nobutaka Fujii, Shinya Oishi
    • Organizer
      254th ACS National Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Presentation] 4-epi-Jaspine B位置異性体の合成と構造活性相関研究2017
    • Author(s)
      宮川貴吏、本田真歩、小林由佳、中村真也、仲西功、藤井信孝、井貫晋輔、大石真也、大野浩章
    • Organizer
      第34回有機合成化学セミナー
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Presentation] Facile access to the mirror-image library of chiral natural product derivatives: identification of MDM2-p53 interaction inhibitor2016
    • Author(s)
      Taro Noguchi, Shinya Oishi, Kaori Honda, Yasumitsu Kondoh, Tamio Saito, Hiroaki Ohno, Hiroyuki Osada, Nobutaka Fujii
    • Organizer
      第8回武田振興財団薬科学シンポジウム
    • Place of Presentation
      武田研修センター（大阪府吹田市）
    • Year and Date
      2016-01-21
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Presentation] Strictamineの不斉形式全合成2016
    • Author(s)
      熊谷洋、西山大亮、大石真也、藤井信孝、大野浩章
    • Organizer
      第42回反応と合成の進歩シンポジウム
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Presentation] 新規合成KSP阻害剤のヒト卵巣がんに対する抗腫瘍効果2016
    • Author(s)
      武永美津子、竹内智起、山本有貴、都倉享恵、新美純、濱口明美、太田有紀、浅井大輔、大石真也、中島秀喜、藤井信孝
    • Organizer
      日本薬学会第１３６年会
    • Place of Presentation
      パシフィコ横浜、横浜市西区
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-15K01319

  • [Presentation] Design of iron-chelating cyclic peptides2016
    • Author(s)
      Yuka Kobayashi, Shinya Oishi, Hiroaki Ohno, Nobutaka Fujii
    • Organizer
      8th International Peptide Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Presentation] Design of Fe(II)-chelaing cyclic hexapeptide with bidentate pyridinyl-triazlole groups2016
    • Author(s)
      Yuka Kobayashi, Shinya Oishi, Hiroaki Ohno, Nobutaka Fujii
    • Organizer
      第53回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Presentation] ヒト乳癌細胞に対する新規KSP(kinesin spindle protein)阻害薬の効果2016
    • Author(s)
      太田有紀, 土屋聖子, 武永美津子, 角田智志, 大滝正訓, 新美純, 大石真也,　藤井信孝, 渡辺実, 武半優子, 飯利太朗, 松本直樹
    • Organizer
      第37回日本臨床薬理学会
    • Place of Presentation
      米子コンベンションセンター（鳥取県・米子市）
    • Year and Date
      2016-12-01
    • Data Source
      KAKENHI-PROJECT-15K10074

  • [Presentation] 長時間作用型PEG化NK3受容体作動薬の創製2016
    • Author(s)
      桑井真司、大石真也、三須良介、大野浩章、山村崇、若林嘉浩、岡村裕昭、藤井信孝
    • Organizer
      日本薬学会第136回年会
    • Place of Presentation
      パシフィコ横浜（神奈川県横浜市）
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Presentation] 新規合成KSP(Kinesin spindle protein)阻害剤のヒト乳癌細胞に対する抗腫瘍効果に関する研究2016
    • Author(s)
      土屋聖子, 太田有紀, 武永美津子, 大滝正訓, 新美純, 大石真也, 藤井信孝, 松本直樹, 津川浩一郎
    • Organizer
      第24回日本乳癌学会学術総会
    • Place of Presentation
      東京ビッグサイト（東京都・江東区）
    • Year and Date
      2016-06-16
    • Data Source
      KAKENHI-PROJECT-15K10074

  • [Presentation] Development of Novel CXCR7 Ligands: Selectivity Switch from CXCR4 Antagonists with Cyclic Pentapeptide Scaffold2016
    • Author(s)
      Tomoko Kuroyanagi, Shinya Oishi, Tatsuhiko Kubo, Yuka Kobayashi, Haruka Sekiguchi, Ryosuke Misu, Hiroaki Ohno, Nicolas Montpas, Nikolaus Heveker, Nobutaka Fujii
    • Organizer
      第8回武田振興財団薬科学シンポジウム
    • Place of Presentation
      武田研修センター（大阪府吹田市）
    • Year and Date
      2016-01-21
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Presentation] Strictamineの全合成研究2016
    • Author(s)
      西山大亮、大原礼子、熊谷洋、千葉浩亮、藤井信孝、大石真也、大野浩章
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Presentation] ケモカイン受容体CXCR7 選択的リガンドの構造最適化研究2016
    • Author(s)
      関口遼、大石真也、黒柳友子、小林由佳、大野浩章、藤井信孝
    • Organizer
      日本ケミカルバイオロジー学会　第11回年会
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Presentation] Total synthesis of a novel cytotoxic depsipeptide from Okinawan marine cyanobacteria2016
    • Author(s)
      Masato Kaneda, Shinya Oishi, Kosuke Sueyoshi, Toshiaki Teruya, Hiroaki Ohno and Nobutaka Fujii
    • Organizer
      第8回武田振興財団薬科学シンポジウム
    • Place of Presentation
      武田研修センター（大阪府吹田市）
    • Year and Date
      2016-01-21
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Presentation] 天然物とその誘導体の鏡像体化合物群の活用を目指した新規スクリーニング法の開発2015
    • Author(s)
      野口太朗、大石真也、本田香織、近藤恭光、斎藤臣雄、大野浩章、長田裕之、藤井信孝
    • Organizer
      日本ケミカルバイオロジー学会　第10回年会
    • Place of Presentation
      東北大学川内キャンパス（宮城県仙台市）
    • Year and Date
      2015-06-10
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Presentation] Development of Novel CXCR7 Ligands by Selectivity Switch from CXCR4 Antagonists with a Cyclic Pentapeptide Scaffold2015
    • Author(s)
      Shinya Oishi, Tomoko Kuroyanagi, Tatsuhiko Kubo, Nicolas Montpas, Yasushi Yoshikawa, Ryosuke Misu, Yuka Kobayashi, Hiroaki Ohno, Nikolaus Heveker, Toshio Furuya, and Nobutaka Fujii
    • Organizer
      AIMECS2015
    • Place of Presentation
      Jeju international convention center（韓国、済州島）
    • Year and Date
      2015-10-18
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Presentation] Identification of a novel MDM2-p53 inhibitor using mirror-image-screening technology for chiral natural products2015
    • Author(s)
      Taro Noguchi, Shinya Oishi, Kaori Honda, Yasumitsu Kondoh, Tamio Saito, Hiroaki Ohno, Hiroyuki Osada, Nobutaka Fujii
    • Organizer
      SKO symposium
    • Place of Presentation
      New Drug Development Center, Seoul University（韓国、ソウル）
    • Year and Date
      2015-11-17
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Presentation] ケモカイン受容体CXCR7選択的リガンドの構造最適化研究2015
    • Author(s)
      黒柳友子，大石真也，小林由佳，関口遼，三須良介，大野浩章，Montpas Nicolas，Heveker Nikolaus，藤井信孝
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      幕張国際研修センター（千葉県幕張市）
    • Year and Date
      2015-11-25
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Presentation] プロパルギル転位を伴う共役ジインの金触媒三連続環化反応を用いたカルバゾールの合成2015
    • Author(s)
      田口将光、時水勇輔、大石真也、藤井信孝、大野浩章
    • Organizer
      第45回複素環化学討論会
    • Place of Presentation
      早稲田大学（東京都新宿区）
    • Year and Date
      2015-11-19
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Presentation] ケモカイン受容体CXCR7選択的リガンドの構造最適化研究2015
    • Author(s)
      黒柳友子，大石真也，久保達彦，三須良介，小林由佳，大野浩章，Montpas Nicolas，Heveker Nikolaus，吉川寧，古谷利夫，藤井信孝
    • Organizer
      第65回日本薬学会　近畿支部総会・大会
    • Place of Presentation
      大阪大谷大学（大阪府羽曳野市）
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Presentation] 環境調和型NK3受容体拮抗剤の創製研究2015
    • Author(s)
      山本昂輝、 大石真也、大野浩章、藤井信孝
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      幕張国際研修センター（千葉県幕張市）
    • Year and Date
      2015-11-25
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Presentation] Novel screening approach for drug discovery from virtual mirror-image library of natural products2015
    • Author(s)
      Taro Noguchi, Shinya Oishi, Kaori Honda, Yasumitsu Kondoh, Tamio Saito, Hiroaki Ohno, Hiroyuki Osada, Nobutaka Fujii
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Hilton Hawaiian Village（アメリカ、ホノルル）
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Presentation] PEG修飾による長時間作用型NK3受容体作動薬の創製2015
    • Author(s)
      桑井真司、 大石真也、三須良介、岡崎志穂、山本昂輝、大野浩章、山村崇、若林嘉浩、岡村裕昭、藤井信孝
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      幕張国際研修センター（千葉県幕張市）
    • Year and Date
      2015-11-25
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Presentation] 共役ジインとピロールを用いた金触媒[4+2]型インドール合成と縮環骨格構築への展開2015
    • Author(s)
      松田優佳、直江紗織、大石真也、藤井信孝、大野浩章
    • Organizer
      第45回複素環化学討論会
    • Place of Presentation
      早稲田大学（東京都新宿区）
    • Year and Date
      2015-11-19
    • Data Source
      KAKENHI-PROJECT-15H04654

  • [Presentation] 化合物アレイを用いた新規MDM2/MDMX-p53阻害剤探索法の開発2013
    • Author(s)
      野口太朗、大石真也、久保達彦、大野浩章、近藤恭光、斎藤臣雄、長田裕之、藤井信孝
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜（神奈川県）
    • Data Source
      KAKENHI-PROJECT-24659046

  • [Presentation] ピリミドベンゾチアジン誘導体の新規合成法の開発と抗HIV剤を指向した構造活性相関研究2012
    • Author(s)
      水原司、大石真也、大野浩章、志村和也、松岡雅雄、藤井信孝
    • Organizer
      第7回日本ケミカルバイオロジー学会年会
    • Place of Presentation
      京都大学（京都府）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] ピリミドベンゾチアジン誘導体の合成法の開発と抗HIV 剤の構造活性相関研究への応用2012
    • Author(s)
      水原司、大石真也、大野浩章、志村和也、松岡雅雄、藤井信孝
    • Organizer
      第42回複素環化学討論会
    • Place of Presentation
      京都テルサ（京都府）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] Potent CXCR4 Antagonists Containing Amidine-type Peptide Bond Isosteres2012
    • Author(s)
      Kubo T, Inokuchi E, Oishi S, Ohno H, Shimura K, Matsuoka M, Fujii N.
    • Organizer
      AIMECS11
    • Place of Presentation
      京王プラザホテル（東京都）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] Jaspine B立体異性体の分岐的合成と構造活性相関研究2012
    • Author(s)
      宮垣潤、吉光佑二、大石真也、大野浩章、藤井信孝
    • Organizer
      第7回日本ケミカルバイオロジー学会年会
    • Place of Presentation
      京都大学（京都府）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] Efficient synthesis of pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives and its application to structure-activity relationship study of anti-HIV agents2012
    • Author(s)
      Mizuhara T, Oishi S, Ohno H, Shimura K, Matsuoka M, Fujii N.
    • Organizer
      第6回武田科学振興財団薬科学シンポジウム
    • Place of Presentation
      武田薬品工業研修所（大阪府）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] Jaspine Bおよびその誘導体の多様性指向型合成研究2012
    • Author(s)
      宮垣潤、吉光佑二、大石真也、藤井信孝、大野浩章
    • Organizer
      第42回複素環化学討論会
    • Place of Presentation
      京都テルサ（京都府）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] Stereoselective divergent synthesis of four diastereomers of pachastrissamine (jaspine B) and their sphingosine kinase inhibitory activities2012
    • Author(s)
      吉光佑二、宮垣潤、大石真也、藤井信孝、大野浩章
    • Organizer
      ISMC2012
    • Place of Presentation
      ベルリン（ドイツ）
    • Data Source
      KAKENHI-PROJECT-24659046

  • [Presentation] Jaspine Bおよびその誘導体の多様性指向型合成2012
    • Author(s)
      宮垣潤、吉光佑二、大石真也、藤井信孝、大野浩章
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学（北海道）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] Stereoselective divergent synthesis of four diastereomers of pachastrissamine (jaspine B) and their sphingosine kinase inhibitory activities2012
    • Author(s)
      吉光佑二、宮垣潤、大石真也、藤井信孝、大野浩章
    • Organizer
      ISMC2012
    • Place of Presentation
      ベルリン（ドイツ）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] Synthesis and anti-HIV activity of pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives2012
    • Author(s)
      Mizuhara T, Oishi S, Ohno H, Shimura K, Matsuoka M, Fujii N.
    • Organizer
      IKCOC-12
    • Place of Presentation
      リーがロイヤルホテル京都（京都府）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] Synthesis and structure-activity relationship study of pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives for development of anti-HIV agents2012
    • Author(s)
      水原司、大石真也、大野浩章、志村和也、松岡雅雄、藤井信孝
    • Organizer
      The 7th SKO Joint Symposium for Young Scientists
    • Place of Presentation
      京都大学（京都府）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] アザインドール骨格またはフェニルアゾール骨格を有する新規プロテインキナーゼCK2阻害剤の開発研究2012
    • Author(s)
      侯増燁、大石真也、武井義則、安江美里、三須良介、鈴木大和、村田克美、北浦和夫、平澤明、辻本豪三、大野浩章、藤井信孝、仲西功、中村真也、呉竜英、木下誉富
    • Organizer
      第10回次世代を担う有機化学シンポジウム
    • Place of Presentation
      大阪大学銀杏会館（大阪府）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] Jaspine Bおよびその誘導体の多様性指向型合成研究2012
    • Author(s)
      宮垣潤、吉光佑二、大石真也、藤井信孝、大野浩章
    • Organizer
      第42回複素環化学討論会
    • Place of Presentation
      京都テルサ（京都府）
    • Data Source
      KAKENHI-PROJECT-24659046

  • [Presentation] Efficient Synthesis of Highly Functionalized Dihydropyrazoles via Gold-Catalyzed Three-Component Annulation2012
    • Author(s)
      Suzuki Y, Oishi S, Fujii N, Ohno H.
    • Organizer
      AIMECS11
    • Place of Presentation
      京王プラザホテル（東京都）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] Efficient Synthesis of Pyrimido[1,2-c]benzothiazin-6-imine and Related Tricyclic Heterocycles by Cu(II)-mediated C-H Functionalization and Aromatic Nucleophilic Substitution2011
    • Author(s)
      Mizuhara T, Oishi S, Fujii N, Ohno H.
    • Organizer
      AIMECS11
    • Place of Presentation
      京王プラザホテル（東京都）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] Synthesis and Biological Evaluation of Novel CXCR4 Antagonists Containing Amidine-type Peptide Bond Isosteres2011
    • Author(s)
      Inokuchi E, Oishi S, Kubo T, Ohno H, Shimura K, Matsuoka M, Fujii N.
    • Organizer
      22nd American Peptide Symposium
    • Place of Presentation
      San Diego（United States of America）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] Structure-activity Relationship Study on a CXCR4 Antagonist FC131 Using Alkene-type Dipeptide Isosteres2011
    • Author(s)
      Kobayashi K, Oishi S, Hayashi R, Tomita K, Kubo T, Tanahara N, Ohno H, Naito T, Matsuoka M, Fujii N.
    • Organizer
      22nd American Peptide Symposium
    • Place of Presentation
      San Diego（United States of America）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] DIVERSITY-ORIENTED SYNTHESIS OF PYRIMIDO[1,2-c][1,3]BENZOTHIAZIN-6-IMINE AND THE RELATED TRICYCLIC HETEROCYCLES2011
    • Author(s)
      Mizuhara T, Oishi S, Ohno H, Fujii N
    • Organizer
      Nature Chemical Biology Symposium 2011: Cancer Chemical Biology
    • Place of Presentation
      Boston（United States of America）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] INTERNALIZATION OF CXC CHEMOKINE RECEPTOR 4 (CXCR4) INDUCED BY POLYPHEMUSIN II-DERIVED ANTAGONIST PEPTIDES2011
    • Author(s)
      Masuda R, Oishi S, Tanahara N, Ohno H, Hirasawa A, Tsujimoto G, Yano Y, Matsuzaki K, Nakase I, Futaki S, Fujii N.
    • Organizer
      第48回ペプチド討論会
    • Place of Presentation
      札幌コンベンションセンター（北海道）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] Jaspine Bおよびその誘導体の多様性指向型合成2011
    • Author(s)
      宮垣潤、吉光佑二、大石真也、藤井信孝、大野浩章
    • Organizer
      第28回有機合成化学セミナー
    • Place of Presentation
      滝の湯（山形県）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] アミジン型ペプチド結合等価体の合成と応用2011
    • Author(s)
      井ノ口恵利子、山田愛、大石真也、久保達彦、大野浩章、保住健太郎、野水基義、志村和也、松岡雅雄、藤井信孝
    • Organizer
      日本ケミカルバイオロジー学会第6回年会
    • Place of Presentation
      東京工業大学大岡山キャンパス（東京都）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] アルケン型及びアミジン型ジペプチドイソスターの合成とCXCR4拮抗剤の構造活性相関研究への応用2011
    • Author(s)
      小林数也、大石真也、井ノ口恵利子、林亮子、富田健嗣、久保達彦、棚原憲子、大野浩章、藤井信孝、吉川寧、古谷利夫、志村和也、松岡雅雄
    • Organizer
      第37回 反応と合成の進歩シンポジウム
    • Place of Presentation
      あわぎんホール（徳島県）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] Gold-catalyzed three-component annulation: an efficient synthesis of 1,2,3,5-tetrasubstituted dihydropyrazoles from alkynes, aldehydes, and hydrazines2011
    • Author(s)
      Suzuki Y, Oishi S, Fujii N, Ohno H.
    • Organizer
      242nd American Chemical Society National Meeting & Exposition
    • Place of Presentation
      Denver（United States of America）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] 金触媒による三成分環形成反応を用いた多置換ジヒドロピラゾールの効率的合成法の開発2011
    • Author(s)
      鈴木大和，大石真也，藤井信孝，大野浩章
    • Organizer
      第37回 反応と合成の進歩シンポジウム
    • Place of Presentation
      あわぎんホール（徳島県）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] 縮環インドール構造を有する新規Eg5阻害剤の開発2011
    • Author(s)
      竹内智起、大石真也、渡部敏明、大野浩章、浅田直也、北浦和夫、澤田潤一、浅井章良、藤井信孝
    • Organizer
      日本ケミカルバイオロジー学会第6回年会
    • Place of Presentation
      東京工業大学大岡山キャンパス（東京都）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] Jaspine Bおよびその誘導体の 立体分岐合成と構造活性相関研究2011
    • Author(s)
      吉光佑二、大石真也、宮垣　潤、井貫晋輔、藤井信孝、大野浩章
    • Organizer
      第7回次世代を担う有機化学シンポジウム
    • Place of Presentation
      日本薬学会長井記念ホール（東京都）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] DEVELOPMENT AND APPLICATION OF FLUORESCENT PROBES FOR MONITORING CXCR4 RECEPTOR INTERNALIZATION2011
    • Author(s)
      Oishi S, Masuda R, Tanahara N, Ohno H, Yano Y, Matsuzaki K, Hirasawa A, Tsujimoto G, Fujii N.
    • Organizer
      Nature Chemical Biology Symposium 2011: Cancer Chemical Biology
    • Place of Presentation
      Boston（United States of America）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] Synthesis and Application of Fluorescent SDF-1 Derivatives2011
    • Author(s)
      Masuda R, Oishi S, Tanahara N, Ohno H, Hirasawa A, Tsujimoto G, Yano Y, Matsuzaki K, Fujii N.
    • Organizer
      22nd American Peptide Symposium
    • Place of Presentation
      San Diego（United States of America）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] Development of a Novel Class of ATP-competitive Kinesin Spindle Protein Inhibitors2011
    • Author(s)
      Oishi S, Takeuchi T, Watanabe T, Ohno H, Sawada J, Matsuno M, Asai A, Asada N, Kitaura K, Fujii N.
    • Organizer
      AIMECS11
    • Place of Presentation
      京王プラザホテル（東京都）
    • Data Source
      KAKENHI-PROJECT-23390025

  • [Presentation] 縮環インドール構造を有する新規Eg5阻害剤の開発2010
    • Author(s)
      竹内智起、大石真也、大野浩章、藤井信孝, 他
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] アルケン型ジペプチドイソスターの合成とケモカイン受容体CXCR4拮抗剤の構造活性相関研究への応用2009
    • Author(s)
      林亮子、大石真也、大野浩章、藤井信孝, 他
    • Organizer
      第28回メディシナルケミストリーシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-11-25
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] Efficient Synthesis of Trifluoromethyl and Related Trisubstituted Alkene Dipeptide Isosteres by Pd-Catalyzed Carbonylation of Amino Acid-Derived Allylic Carbonates2009
    • Author(s)
      Inokuchi E, Oishi S, Ohno H, Fujii N, et al.
    • Organizer
      8th Australian Peptide Conference
    • Place of Presentation
      Queensland Australia
    • Year and Date
      2009-10-12
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Presentation] 固相上におけるペプチド鎖へのDTPAの新規標識法の開発2009
    • Author(s)
      増田亮、大石真也、大野浩章、藤井信孝, 他
    • Organizer
      第46回ペプチド討論会
    • Place of Presentation
      北九州
    • Year and Date
      2009-11-04
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Presentation] アルケン型ジペプチドイソスターの合成とケモカイン受容体CXCR4拮抗剤の構造活性相関研究への応用2009
    • Author(s)
      林亮子、大石真也、大野浩章、藤井信孝, 他
    • Organizer
      第59回日本薬学会近畿支部総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] カルバゾール骨格を有する新規Eg5阻害剤のデザインと合成2009
    • Author(s)
      渡部敏明、大石真也、大野浩章、藤井信孝, 他
    • Organizer
      日本ケミカルバイオロジー研究会第4回年会
    • Place of Presentation
      神戸
    • Year and Date
      2009-05-19
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] ケモカイン受容体CXCR4選択的蛍光プローブを活用した新規化合物評価系の構築2009
    • Author(s)
      棚原憲子、大石真也、大野浩章、藤井信孝, 他
    • Organizer
      第59回日本薬学会近畿支部総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] 有機銅-亜鉛複合試薬を用いたトリフルオロメチルアルケンジペプチドイソスターの新規合成法の開発2009
    • Author(s)
      小林数也、大石真也、大野浩章、藤井信孝, 他
    • Organizer
      第35回反応と合成の進歩シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-11-16
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Presentation] ケモカイン受容体CXCR4選択的蛍光プローブを活用した化合物評価系の構築2009
    • Author(s)
      棚原憲子、大石真也、大野浩章、藤井信孝, 他
    • Organizer
      第46回ペプチド討論会
    • Place of Presentation
      北九州
    • Year and Date
      2009-11-04
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] アルケン型ジペプチドイソスターの合成とケモカイン受容体CXCR4拮抗剤の構造活性相関研究への応用2009
    • Author(s)
      林亮子、大石真也、大野浩章、藤井信孝, 他
    • Organizer
      日本ケミカルバイオロジー研究会第4回年会
    • Place of Presentation
      神戸
    • Year and Date
      2009-05-18
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Presentation] ケモカイン受容体CXCR4選択的蛍光プローブを活用した新規化合物評価系の構築2009
    • Author(s)
      棚原憲子、大石真也、大野浩章、藤井信孝, 他
    • Organizer
      第59回日本薬学会近畿支部総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Presentation] アルケン型ジペプチドイソスターの合成とケモカイン受容体CXCR4拮抗剤の構造活性相関研究への応用2009
    • Author(s)
      林亮子、大石真也、大野浩章、藤井信孝, 他
    • Organizer
      第59回日本薬学会近畿支部総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Presentation] ペプチドミメティクスの利用による新規GPR54アゴニストの創製2009
    • Author(s)
      説田章平、大石真也、大野浩章、藤井信孝, 他
    • Organizer
      第6回GPCR研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-08
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] ペプチドミメティクスの利用による新規GPR54アゴニストの創製2009
    • Author(s)
      説田章平、大石真也、大野浩章、藤井信孝, 他
    • Organizer
      第6回GPCR研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-08
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Presentation] Synthesis and Application of Novel Fluorescent-Labeled CXCR4 Antagonists2009
    • Author(s)
      増田亮、大石真也、大野浩章、藤井信孝, 他
    • Organizer
      第10回文部科学省特定領域研究「がん」5領域 若手研究者ワークショップ
    • Place of Presentation
      蓼科
    • Year and Date
      2009-09-02
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Presentation] 固相上におけるペプチド鎖へのDTPAの新規標識法の開発2009
    • Author(s)
      増田亮、大石真也、大野浩章、藤井信孝, 他
    • Organizer
      第46回ペプチド討論会
    • Place of Presentation
      北九州
    • Year and Date
      2009-11-04
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] アルケン型ジペプチドイソスターの合成とケモカイン受容体CXCR4拮抗剤の構造活性相関研究への応用2009
    • Author(s)
      林亮子、大石真也、大野浩章、藤井信孝, 他
    • Organizer
      日本ケミカルバイオロジー研究会第4回年会
    • Place of Presentation
      神戸
    • Year and Date
      2009-05-18
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] ケモカイン受容体CXCR4選択的蛍光プローブを活用した化合物評価系の構築2009
    • Author(s)
      棚原憲子、大石真也、大野浩章、藤井信孝, 他
    • Organizer
      第46回ペプチド討論会
    • Place of Presentation
      北九州
    • Year and Date
      2009-11-04
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Presentation] Synthesis and Application of Novel Fluorescent-Labeled CXCR4 Antagonists2009
    • Author(s)
      増田亮、大石真也、大野浩章、藤井信孝, 他
    • Organizer
      第10回文部科学省特定領域研究「がん」5領域 若手研究者ワークショップ
    • Place of Presentation
      蓼科
    • Year and Date
      2009-09-02
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] アルケン型ジペプチドイソスターの合成とケモカイン受容体CXCR4拮抗剤の構造活性相関研究への応用2009
    • Author(s)
      林亮子、大石真也、大野浩章、藤井信孝, 他
    • Organizer
      第28回メディシナルケミストリーシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-11-25
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Presentation] 縮環インドール構造を有する新規Eg5阻害剤の開発2009
    • Author(s)
      竹内智起、大石真也、大野浩章、藤井信孝, 他
    • Organizer
      第28回メディシナルケミストリーシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-11-25
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] CXCR4受容体アンタゴニストの蛍光標識体の創製と応用2008
    • Author(s)
      増田亮、大石真也、藤井信孝、他
    • Organizer
      日本ケミカルバイオロジー研究会第3回年会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-19
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] 多様なジペフチドイゾースターの分岐的合成とGPR54アゴニストへの応用2008
    • Author(s)
      富田健嗣、大石真也、藤井信孝、他
    • Organizer
      第27回メディシナルケミストリーシンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2008-11-26
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Presentation] Development of novel non-peptide CXCR4 antagonists based on cyclic peptide structure2008
    • Author(s)
      Oishi S., Katoh M., Ueda S., Inuki S., Ohno H., Barry Evans, Zi-xuan Wang, Stephen C. Peiper, Fujii N.
    • Organizer
      3rd Annual Meeting of Japan Chemical Biology Society
    • Place of Presentation
      Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Development of Novel Pseudopeptide GPR54 Agonists with High Tolerance against MMP-Mediaed Digestion2008
    • Author(s)
      Kenji Tomita, Shinya Oishi,Nobutaka Fujii, 他
    • Organizer
      XXth International Symposium on Medicinal Chemistry
    • Place of Presentation
      ウイーン
    • Year and Date
      2008-09-01
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Presentation] 新規ファルマコフォアを有するケモカインレセプターCXCR4アンタゴニストの構造活性相関研究2008
    • Author(s)
      田中智博、大石真也、藤井信孝、他
    • Organizer
      日本ケミカルバイオロジー研究会第3回年会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-20
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] CXCR4 Antagonists : Relevance to Cancer Chemotherapy2008
    • Author(s)
      Nobutaka Fujii, Shinya Oishi
    • Organizer
      XXth International Symposium on Medicinal Chemistry
    • Place of Presentation
      ウイーン
    • Year and Date
      2008-09-03
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Presentation] マトリックスメタロプロテアーゼ耐性GPR54アゴニストの開発2008
    • Author(s)
      富田健嗣、大石真也、藤井信孝、他
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Presentation] Novel labeling protocol for cell-membrane proteins by tag-probe method-2008
    • Author(s)
      Yano Y., Yano A., Oishi S., Sugimoto Y., Tsujimoto G., Fujii N., Matsuszaki K.
    • Organizer
      The 128th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Synthesis and application of fluorescent CXCR4 antagonist2008
    • Author(s)
      Masuda R., Oishi S., Ueda S., Evans B., Peiper SC, Hirasawa A., Tsujimoto G., Ohno H., Fujii N.
    • Organizer
      3rd Annual Meeting of Japan Chemical Biology Society
    • Place of Presentation
      Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Chemical Virologyを基盤とする新興・再興ウイルス侵入阻害剤の開発研究2008
    • Author(s)
      藤井信孝
    • Organizer
      第4回ケミカルバイオロジーシンポジウム-化学-生物融合領域創成の軌跡-
    • Place of Presentation
      熱海
    • Year and Date
      2008-02-07
    • Data Source
      KAKENHI-PROJECT-18060020

  • [Presentation] Chemical Virologyを基盤とする新興・再興ウイルス侵入阻害剤の開発研究2008
    • Author(s)
      藤井信孝
    • Organizer
      第4回ケミカルバイオロジーシンボジウムー化学-生物融合領域創成の軌跡-
    • Place of Presentation
      熱海
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] 求核的CF3化反応による立体選択的トリフルオロメチルアルケン型ジペプチドイソスターの合成研究2008
    • Author(s)
      小林数也、大石真也、藤井信孝、他
    • Organizer
      第58回日本薬学会近畿支部総会
    • Place of Presentation
      神戸
    • Year and Date
      2008-10-25
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Presentation] Design and synthesis of anti-HIV peptides having helix-inducible motifs2008
    • Author(s)
      Watanabe K., Oishi S., Itoh S., Tanaka M., Hishikawa H., Watabe T., Izumi K., Sakagami Y., Kodama E., Matsuoka M., Ohno H., Fujii N.
    • Organizer
      The 128th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] ジペプチドイソスターの分岐型合成による酵素耐性GPR54アゴニストの創出2008
    • Author(s)
      富田健嗣、大石真也、藤井信孝、他
    • Organizer
      第34回反応と合成の進歩シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2008-11-04
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Presentation] Model development for virtual screening of CYP-interactive compounds using CCA spatial model2008
    • Author(s)
      Ogawa T., Minowa Y., Adachi T., Feng C, Niijima S., Oishi S., Fujii N., Okuno Y.
    • Organizer
      5th Seminars on Biomedical Researches
    • Place of Presentation
      Osaka
    • Year and Date
      2008-02-13
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] X-ray crystal structure analysis of 6-helical bundle structure of T-20 (Fuzeon) -resistant HIV mutants2008
    • Author(s)
      Watabe T., Oishi S., Nishikawa H., Watanabe K., Nakano H., Nakatsu T., Ohno H., Katoh H., Kodama E., Matsuoka M., Fujii N.
    • Organizer
      88th Spring meeting of the chemical society of Japan
    • Place of Presentation
      Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] 多様なジペプチドイソスターの分岐的合成と応用2008
    • Author(s)
      富田健嗣、大石真也、藤井信孝、他
    • Organizer
      第28回有機合成若手セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2008-11-12
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Presentation] ケモカイン受容体CXCR4に対する蛍光標識リカンドの創製と応用2008
    • Author(s)
      増田亮、大石真也、藤井信孝、他
    • Organizer
      第58回日本薬学会近畿支部総会
    • Place of Presentation
      神戸
    • Year and Date
      2008-10-25
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Presentation] 求核的CF3化反応による立体選択的トリフルオロメチルアルケン型ジペプチドイソスターの合成研究2008
    • Author(s)
      小林数也、大石真也、藤井信孝、他
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Presentation] 環状ペプチドをリードとする非ペプチド性CXCR4拮抗剤の開発2008
    • Author(s)
      大石真也、藤井信孝、他
    • Organizer
      日本ケミカルバイオロジー研究会第3回年会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-19
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] 求核的CF3化反応による立体選択的トリフルオロメチルアルケン型ジペプチドイソスターの合成研究2008
    • Author(s)
      小林数也、大石真也、藤井信孝、他
    • Organizer
      第58回日本薬学会近畿支部総会
    • Place of Presentation
      神戸
    • Year and Date
      2008-10-25
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] Structure-activity relathionship on pyrazine-based CK2 inhibitors2008
    • Author(s)
      Suzuki Y., Cluzeau J., Oishi S., Ohno H., Fujii N., Hara T., Hirasawa A., Tsujimoto G.
    • Organizer
      The 128th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Establishment of bioevaluation technology for drug discovery for GPCR -novel labeling protocol for cell-membrane proteins by tag-probe method-2008
    • Author(s)
      Yano Y., Oishi S., Sugimoto Y., Tsujimoto G., Fujii N., Matsuzaki K.
    • Organizer
      The 1st Symposium on Target Protein Research Program
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-02-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Development of anti viral agents of emerging and re-emerging viruses based on chemical virology2008
    • Author(s)
      Fujii N.
    • Organizer
      The 4th Chemical Biology Symposium
    • Place of Presentation
      Atami
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] 求核的CF3化反応による立体選択的トリフルオロメチルアルケン型ジペプチドイソスターの合成研究2008
    • Author(s)
      小林数也、大石真也、藤井信孝、他
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] CXCR4受容体アンタゴニストの蛍光標識体の創製と応用2008
    • Author(s)
      増田亮、大石真也、藤井信孝、他
    • Organizer
      第41回若手ペプチド夏の勉強会
    • Place of Presentation
      京都
    • Year and Date
      2008-08-04
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Presentation] 多様なジペプチドイソスターの分岐的合成と応用2008
    • Author(s)
      富田健嗣、大石真也、藤井信孝、他
    • Organizer
      第28回有機合成若手セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2008-11-12
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] CXCR4 Antagonists: Relevance to Cancer Chemotherapy2008
    • Author(s)
      Nobutaka Fujii, Shinya Oishi
    • Organizer
      XXth International Symposium on Medicinal Chemistry
    • Place of Presentation
      ウイーン
    • Year and Date
      2008-09-03
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] Contribution to chemical library by preparation of novel fragment compound -efficient synthesis of multi-substituted heterocycles having drug-like strucure-2008
    • Author(s)
      Fujii N., Ohno H., Oishi S., Takemoto Y., Takasu K, Yasui Y., Tomioka K., Yamada K., Yamamoto Y.
    • Organizer
      The 1st Symposium on Target Protein Research Program
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-02-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] 化合物の提供と新規フラグメント化合物群の創製による化合物ライブラリー充実への貢献-ドラッグライク構造を有する多置換型複素環の効率的合成法の開発-2008
    • Author(s)
      藤井信孝, et al.
    • Organizer
      ターゲットタンパク研究プログラム第1回公開シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-02-12
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Synthesis and application of Z-alkene and E-fluoroalkene dipeptide isosteres as cis-amide bond equivalents2008
    • Author(s)
      Tomita K, Narumi T., Niida A., Oishi S., Ohno H., Fujii N.
    • Organizer
      The 128th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] ジペプチドイソスターの分岐型合成による酵素耐性GPR54アゴニストの創出2008
    • Author(s)
      富田健嗣、大石真也、藤井信孝、他
    • Organizer
      第34回反応と合成の進歩シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2008-11-04
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] 環状ペンタペプチド骨格を有するCXCR4アンタゴニスドの構造活性相関研究 : 新規ファルマコフォアの同定2008
    • Author(s)
      田中智博、藤井信孝、他
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-30
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] Synthesis of nitrogen heterocycles by palladium-catalyzed sp3 C-H activation.2008
    • Author(s)
      Toshiaki Watanabe, Shinya Oishi, Nobutaka Fujii, Hiroaki Ohno
    • Organizer
      The 9th Youngnam-Kinki Joint Symposium on Organometallic Chemistry
    • Place of Presentation
      Kyoto
    • Year and Date
      2008-01-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] CXCR4受容体アンタゴニストの蛍光標識体の創製と応用2008
    • Author(s)
      増田亮、大石真也、藤井信孝、他
    • Organizer
      第41回若手ペプチド夏の勉強会
    • Place of Presentation
      京都
    • Year and Date
      2008-08-04
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] Development of screening system for anti-cancer lead compounds -for HIF-1-targeting agents -2008
    • Author(s)
      Hattori A., Yagura T., Nishimura S., Oishi S., Fujii N., Kakeya H.
    • Organizer
      The 1st Symposium on Target Protein Research Program
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-02-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Selection of Chemicals for General Library2008
    • Author(s)
      Yasuno K., Kojima H., Okabe T., Oishi S., Fujii N., Nagano T. Furuya T.
    • Organizer
      The 1st Symposium on Target Protein Research Program
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-02-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] 環状ペンタペプチド骨格を有するCXCR4アンタゴニストの構造活性相関研究 : 新規ファルマコフォアの同定2008
    • Author(s)
      田中智博、藤井信孝、他
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-30
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Presentation] Development of novel in silico technology based on compounds-protein interactions2008
    • Author(s)
      Ogawa T., Kitajima M., Minowa Y., Matsuda H., Fujii N., Okuno Y.
    • Organizer
      The 128th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] 多様なジペプチドイソスターの分岐的合成とGPR54アゴニストへの応用2008
    • Author(s)
      富田健嗣、大石真也、藤井信孝、他
    • Organizer
      第27回メディシナルケミストリーシンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2008-11-26
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] 環状ペプチドをリードとする非ペプチド性CXCR4拮抗剤の開発2008
    • Author(s)
      大石真也、藤井信孝、他
    • Organizer
      日本ケミカルバイオロジー研究会第3回年会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-19
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Presentation] 新規ファルマコフォアを有するケモカインレセプターCXCR4アンタゴニストの構造活性相関研究2008
    • Author(s)
      田中智博、大石真也、藤井信孝、他
    • Organizer
      日本ケミカルバイオロジー研究会第3回年会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-20
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Presentation] Development of Novel Pseudopeptide GPR54 Agonists withHigh Tolerance against MMP-Mediaed Digestion2008
    • Author(s)
      Kenji Tomita, Shinya Oishi, Nobutaka Fujii, 他
    • Organizer
      XXth International Symposium on Medicinal Chemistry
    • Place of Presentation
      ウイーン
    • Year and Date
      2008-09-01
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] Synthesis and application of fluorescent CXCR4 antagonist2008
    • Author(s)
      Masuda R., Oishi S., Ueda S., Barry Evans, Stephen C. Peiper, Hirasawa A., Tsujimoto G., Ohno H., Fujii N.
    • Organizer
      The 128th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Stereoselective synthesis of trifluoromethylalkene dipeptide isosteres by nucliophilic CF3-introduction2008
    • Author(s)
      Kobayashi K., Narumi T., Inokuchi E., Tomita K., Oishi S., Ohno H., Fujii N.
    • Organizer
      The 128th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] ケモカイン受容体CXCR4に対する蛍光標識リガンドの創製と応用2008
    • Author(s)
      増田亮、大石真也、藤井信孝、他
    • Organizer
      第58回日本薬学会近畿支部総会
    • Place of Presentation
      神戸
    • Year and Date
      2008-10-25
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] Structure-activity relathionship on pyrazine-based CK2 inhibitors2008
    • Author(s)
      Suzuki Y., Jerome Cluzeau, Hara T., Hirasawa A., Tsujimoto G., Oishi S., Ohno H., Fujii N.
    • Organizer
      3rd Annual Meeting of Japan Chemical Biology Society
    • Place of Presentation
      Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] マトリックスメタロプロテアーゼ耐性GPR54アゴニストの開発2008
    • Author(s)
      富田健嗣、大石真也、藤井信孝、他
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-20015021

  • [Presentation] Structure-activity relationship on CXCR4 antagonists having novel pharmacophores2008
    • Author(s)
      Tanaka T., Nomura W., Tsutsumi H., Tabe Y., Ohhashi N., Itoya K., Oishi S., Fujii N., Evans B., Wang Z., Peiper SC, Tamamura H.
    • Organizer
      3rd Annual Meeting of Japan Chemical Biology Society
    • Place of Presentation
      Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] CXCR4受容体アンタゴニストの蛍光標識体の創製と応用2008
    • Author(s)
      増田亮、大石真也、藤井信孝、他
    • Organizer
      日本ケミカルバイオロジー研究会第3回年会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-19
    • Data Source
      KAKENHI-PROJECT-20057011

  • [Presentation] Structure-activity relationship study on GPR54 agonist as novel anti-metastatic agent.2007
    • Author(s)
      Tomita K., Oishi S., Ohno H., Akamatsu M., Fujii N.
    • Organizer
      First JCA-AACR Special Joint Conference : The Latest Advances in Lung Cancer Research : From Basic Science to Therapeutics
    • Place of Presentation
      Nagoya
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Synthesis of fluoroalkene isosteres using intramolecular redox reaction by N-heterocyclic carbene2007
    • Author(s)
      Yamaki Y., Shigenaga A., Tomita K., Narumi T., Fujii N., Otaka A.
    • Organizer
      The 127th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Toyama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] From amino acids to peptide isosteres: Implication to genome-lead drug discovery.2007
    • Author(s)
      Fujii N., Oishi S., Narumi T., Tomita K., Ohno H.
    • Organizer
      2nd. World Congress of Pharmacy and Pharmaceutical Sciences
    • Place of Presentation
      Beijing
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Synthesis and application of fluorescent CXCR4 antagonist2007
    • Author(s)
      Masuda R., Oishi S., Ueda S., Gotoh S., Ohno H., Evans B., Peiper SC, Hirasawa A., Tsujimoto G., Kodama E., Matsuoka M., Fujii N.
    • Organizer
      44th Japanese Peptide Symposium
    • Place of Presentation
      Toyama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] CXCR4 antagonists : Relevance to small cell lung cancer chemotherapy.2007
    • Author(s)
      Fujii N., Oishi S., Ueda S.
    • Organizer
      First JCA-AACR Special Joint Conference : The Latest Advances in Lung Cancer Research : From Basic Science to Therapeutics
    • Place of Presentation
      Nagoya
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Anti-HIV activity of water-soluble analogue of C29, SC29EK2007
    • Author(s)
      Naitoh T., Izumi K., Kodama E., Oishi S., Fujii N., Matsuoka M.
    • Organizer
      21st Annual meeting of the Japan Society for AIDS research
    • Place of Presentation
      Hiroshima
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Stereoselective synthesis of peptidomimetics based on acid-catalyzed ring-opening of □-aziridinyl-□, □-enoates.2007
    • Author(s)
      Tamamura H., Tanaka T., Tsutsumi H., Nemoto K., Mizokami S., Ohashi N., Oishi S., Fujii N.
    • Organizer
      20th American Peptide Symposium
    • Place of Presentation
      Montreal
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] CXCR4 Antagonists; Relevance to Cancer Chemotherapy2007
    • Author(s)
      Fujii N.
    • Organizer
      6th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      Istanbul
    • Year and Date
      2007-07-11
    • Data Source
      KAKENHI-PROJECT-18659027

  • [Presentation] One-pot synthesis of carbazoles by palladium-catalyzed N-arylation and oxidative coupling2007
    • Author(s)
      Watanabe T., Inuki S., Ueda S., Oishi S., Ohno H., Fujii N.
    • Organizer
      6th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      Istanbul
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] From knowledge to controlling : implications of peptide-lead drug templates for genome-lead discovery.2007
    • Author(s)
      Nobutaka Fujii, Hiroaki Ohno, Shinya Oishi
    • Organizer
      RIKEN International Symposium on Chemical Biology
    • Place of Presentation
      Hakone
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Construction of 2-(aminomethyl)indole motif by Cu-catalyzed multi-component reaction.2007
    • Author(s)
      Ohta Y., Oishi S., Fujii N., Ohno H.
    • Organizer
      234th ACS meeting & exposition
    • Place of Presentation
      Boston
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Plasma concentration of metastins in pancreatic cancer patients2007
    • Author(s)
      Katagiri F., Nagai K., Kida M., Tomita K., Oishi S., Takeyama M., Doi R., Fujii N.
    • Organizer
      2nd annual meeding of Japan Chemical Biology Society
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Development of synthetic methodology for fused aromatic compounds by consecutive bond formations2007
    • Author(s)
      Ohno H., Ohta Y., Oishi S., Fujii N., Iuchi M., Tanaka T.
    • Organizer
      The 33rd Symposium on Progress in Organic Reactions in the Life Sciences
    • Place of Presentation
      Nagasaki
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Pd-Catalyzed carbonylation of CF3-containing allylic carbonate : application to the synthesis of (Z)-trifluoromethylalkene dipeptide isosteres.2007
    • Author(s)
      Inokuchi E., Narumi T., Tomita K., Niida A., Kobayashi K., Oishi S., Ohno H., Fujii N.
    • Organizer
      14th IUPAC Symposium on Organometallic Chemistry Directed Towards Organic Synthesis
    • Place of Presentation
      Nara
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] 情報から制御へ : ゲノム情報収斂型創薬科学2007
    • Author(s)
      藤井信孝
    • Organizer
      21C0E公開シンポジウム
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Development of a novel fusion inhibitor against T-20-resistant HIV-1.2007
    • Author(s)
      Oishi S., Ito S., Nishikawa H., Tanaka M., Ohno H., Otaka A., Izumi K., Kodama E., Matsuoka M., Fujii N.
    • Organizer
      20th American Peptide Symposium
    • Place of Presentation
      Montreal
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Development of fusion inhibitors against feline immunodeficiency virus (FIV)2007
    • Author(s)
      Nishikawa H., Kodera Y., Tanaka M., Mizukoshi F., Tsujimoto H., Kodama E., Matsuoka M., Oishi S., Ohno H., Fujii N.
    • Organizer
      2nd annual meeding of Japan Chemical Biology Society
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Synthesis of trifluoroalkene dipeptide isosteres and the related compounds using paradium-catalyzed carbonylation2007
    • Author(s)
      Inokuchi E., Narumi T., Niida A., Tomita K, Oishi S., Ohno H., Fujii N.
    • Organizer
      27th Seminars on Organic Synthesis for Young Scientists
    • Place of Presentation
      Kyoto
    • Year and Date
      2007-11-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] From knowledge to controlling : implications of peptide-lead drug templates for genome-lead discovery2007
    • Author(s)
      Nobutaka Fujii, et al.
    • Organizer
      RIKEN International Symposium on Chemical Biology
    • Place of Presentation
      箱根
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Development of novel FIV membrane fusion inhibitors.2007
    • Author(s)
      Nishikawa H., Kodera Y., Oishi S., Tanaka M., Tochikura T., Kajiwara K., Ohno H., Mizukoshi F., Tsujimoto H., Kodama E., Matsuoka M., Fujii N.
    • Organizer
      Virus Molecular Interactions : Therapeutic Targets
    • Place of Presentation
      Oxford
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] 98. CXCE4 antagonists : relevance to cancer chemotherapy2007
    • Author(s)
      Kobutaka Fujii
    • Organizer
      6th AFMC IEternational Medicinal Chemistry Symposium
    • Place of Presentation
      イスタンブール
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] CXCR4 antagonists ; relevance to cancer chemotherapy.2007
    • Author(s)
      Fujii N.
    • Organizer
      6th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      Istanbul
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] CXCR4 antagonists; relevance to cancer chemotherapy2007
    • Author(s)
      Nobutaka Fujii
    • Organizer
      6th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      イスタンブール
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Synthesis and in vivo evaluation of 18F labeled fluorobenzoyl pentapeptide ([18F]TOM80) as a PET imaging agent for GPR54.2007
    • Author(s)
      T. Fuchigami, N. Harada, H. Tsukada, M. Ogawa, H. Yamaguchi, H. Raku, K. Tomita, S. Ohishi, N. Fujii, Y. Magata
    • Organizer
      Seventh Japan-China Joint Semiinar on Radiopharmaceutical Chemistry
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Synthesis and application of (Z)-alkene- and (E)-fluoroalkene-dipeptide isosteres as cis-amide equivalents.2007
    • Author(s)
      Tomita K., Narumi T., Niida A., Oishi S., Ohno H., Fujii N.
    • Organizer
      20th American Peptide Symposium
    • Place of Presentation
      Montreal
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Synthesis of bicyclic heterocycles by paradium-catalyzed domino cyclizations of propargyl bromide2007
    • Author(s)
      Okano A., Ohno H., Fujii N., Kosaka S., Ohhata M., Ishihara K., Tanaka T. Tsukamoto K.
    • Organizer
      The 33rd Symposium on Progress in Organic Reactions in the Life Sciences
    • Place of Presentation
      Nagasaki
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Synthesis of trifluoroalkene dipeptide isosteres and the related compounds using paradium-catalyzed carbonylation2007
    • Author(s)
      Inokuchi E., Narumi T., Niida A., Oishi S., Ohno H., Fujii N.
    • Organizer
      The 33rd Symposium on Progress in Organic Reactions in the Life Sciences
    • Place of Presentation
      Nagasaki
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] From information to controls : Drug discovery based on genomeinformation2007
    • Author(s)
      Fujii N.
    • Organizer
      21COE symposium
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Design and synthesis of anti-HIV peptides having helix-inducible motifs2007
    • Author(s)
      Watanabe K., Itoh S., Nishikawa H., Tanaka M., Oishi S., Ohno H., Izumi K., Kodama E., Matsuoka M., Fujii N.
    • Organizer
      44th Japanese Peptide Symposium
    • Place of Presentation
      Toyama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Synthesis and structure-activity relationship on cystein derivatives having Eg5 inhibiory activity2007
    • Author(s)
      Ogo N., Oishi S., Matsuno K., Sawada J., Fujii N., Asai A.
    • Organizer
      The 26th Symposium on Medicinal Chemistry
    • Place of Presentation
      Sagamihara
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Synthesis of fluoroalkenes of organometal-mediated C-F bond cleavage : application of stereoselective synthesis of multifunctionalized fluoroalkene dipeptide isosteres2007
    • Author(s)
      Narumi T., Tomita K., Inokuchi E., Kobayashi K., Oishi S., Ohno H., Fujii N.
    • Organizer
      The 57th Kinki Regional Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Osaka
    • Year and Date
      2007-10-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Synthesis and application of carbazoles by palladium-catalyzed tandem N-arylation and oxidative C-H activation2007
    • Author(s)
      Watanabe T., Ueda S., Oishi S., Fujii N., Ohno H.
    • Organizer
      Eighth Tetrahedron Symposium
    • Place of Presentation
      Berlin
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Development of novel CXCR4 antagonist having an indole scaffold2007
    • Author(s)
      Katoh M., Ueda S., Inuki S., Oishi S., Ohno H., Evans B., Wang Z., Peiper SC, Fujii N.
    • Organizer
      The 26th Symposium on Medicinal Chemistry
    • Place of Presentation
      Sagamihara
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] CXCR4 Antagonists; Relevance to Cancer Chemotherapy.2007
    • Author(s)
      Nobutaka Fujii
    • Organizer
      6th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      Istanbul
    • Year and Date
      2007-07-11
    • Data Source
      KAKENHI-PROJECT-18015027

  • [Presentation] Prediction of drugcytochrome P450 interaction using chemical-biological correlation space model.2007
    • Author(s)
      Teppei Ogawa, Yosuke Minowa, Tetsuya Adachi, Chunlai Fen, Satoshi Niijima, Shinya Oishi, Nobutaka Fujii, Yasushi Okuno
    • Organizer
      Annual meeding of CBI society
    • Place of Presentation
      Hiroshima
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Development of fusion inhibitors based on resistant mutation against T-202007
    • Author(s)
      Izumi K., Kodama E., Shimura K., Oishi S., Fujii N., Matsuoka M.
    • Organizer
      21st Annual meeting of the Japan Society for AIDS research
    • Place of Presentation
      Hiroshima
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Palladium-catalyzed synthesis of carbazole by tandem N-arylation and C-H activation.2007
    • Author(s)
      Watanabe T., Ueda S., Oishi S., Fujii N., Ohno H.
    • Organizer
      The 5th Symposium on Organic Chemistry - The Next Generation
    • Place of Presentation
      Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Stereoselective synthesi of (Z)-trifluoromethylalkene dipeptide isosteres2007
    • Author(s)
      Inokuchi E., Narumi T., Niida A., Kobayashi K., Oishi S., Ohno H., Fujii N.
    • Organizer
      The 127th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Toyama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] From Amino Acids to Peptide Isosteres: Implication to Genome-lead drug discovery.2007
    • Author(s)
      Fujii N
    • Organizer
      2. World Congress of Pharmacy and Pharmaceutical Sciences
    • Place of Presentation
      Beijing
    • Year and Date
      2007-09-06
    • Data Source
      KAKENHI-PROJECT-18015027

  • [Presentation] Construction of 2-(aminomethyl)indole motif by Cu-catalyzed multi-component reaction.2007
    • Author(s)
      Ohta Y., Oishi S., Fujii N., Ohno H.
    • Organizer
      14th IUPAC Symposium on Organometallic Chemistry Directed Towards Organic Synthesis
    • Place of Presentation
      Nara
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Synthesis and application of (Z)-alkene and (E)-fluoroalkene dipeptide isosteres as cis amide equivalents2007
    • Author(s)
      Tomita K., Narumi T., Niida A., Oishi S., Ohno H., Fujii N.
    • Organizer
      2nd annual meeding of Japan Chemical Biology Society
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] 情報から制御へ:ゲノム情報収斂型創薬科学2007
    • Author(s)
      藤井信孝
    • Organizer
      21COE公開シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2007-09-20
    • Data Source
      KAKENHI-PROJECT-18060020

  • [Presentation] From amino acids to peptide isosteres : Implication to genome-lead drug discovery2007
    • Author(s)
      Nobutaka Fujii, et al.
    • Organizer
      2nd. World Congress of Pharmacy and Pharmaceutical Sciences
    • Place of Presentation
      北京
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Fluoroalkenes for peptidomimetics2007
    • Author(s)
      Narumi T., Tomita K., Inokuchi E., Kobayashi K., Oishi S., Ohno H., Fujii N.
    • Organizer
      44th Japanese Peptide Symposium
    • Place of Presentation
      Toyama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] 情報から制御へ:ゲノム情報収斂型創薬科学2007
    • Author(s)
      藤井信孝
    • Organizer
      21COE公開シンポジウム
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Development of Highly potent HIV fusion inhibitors2007
    • Author(s)
      Tanaka M., Itoh S., Oishi S., Nishikawa H., Izumi K., Kodama E., MatsuokE M., Ohno H., Fujii N.
    • Organizer
      2nd annual meeding of Japan Chemical Biology Society
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] From Amino Acids to Peptide Isosteres: Implication to Genome-lead drug discovery.2007
    • Author(s)
      Fujii N
    • Organizer
      2. World Congress of Pharmacy and Pharmaceutical Sciences
    • Place of Presentation
      Beijing
    • Year and Date
      2007-09-06
    • Data Source
      KAKENHI-PROJECT-18060020

  • [Presentation] HIV activity of T-20 derivatives2007
    • Author(s)
      Shimane K., Izumi K., Kodama E., Oishi S., Fujii N., Matsuoka M.
    • Organizer
      21st Annual meeting of the Japan Society for AIDS research
    • Place of Presentation
      Hiroshima
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Development of chemokine receptor CXCE4 antagonists using bio-mimetic strategy.2007
    • Author(s)
      Tamamura H., Tanaka T., Tsutsumi H., Ohashi N., Hiramatsu K., Araki T., Ojida A., Hamachi I., Wang Z., Peiper SC, Trent JO., Ueda S., Oishi S., Fujii N.
    • Organizer
      20th American Peptide Symposium
    • Place of Presentation
      Montreal
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Palladium-catalyzed synthesis of carbazole by tandem N-arylation and C-H activation.2007
    • Author(s)
      Watanabe T., Ueda S., Oishi S., Fujii N., Ohno H.
    • Organizer
      The 127th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Toyama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] CXCR4 antagonists : Relevance to small cell lung cancer chemotherapy.2007
    • Author(s)
      Nobutaka Fujii, et al.
    • Organizer
      First JCA-AACR Special Joint Conference : The Latest Advances in Lung Cancer Research : From Basic Science to Therapeutics
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Development of highly potent HIV fusion inhibitors by application of EK concept2007
    • Author(s)
      Itoh S., Oishi S., Nishikawa H., Tanaka M., Watanabe K., Izumi K., Kodama E., Matsuoka M., Ohno H., Fujii N.
    • Organizer
      The 127th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Toyama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Structure-affinity relationship study on fluorobenzoyl pentapeptides for GPR542007
    • Author(s)
      Tomita K., Oishi S., Ohno H., Fujii N.
    • Organizer
      The 127th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Toyama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Propertie of intracellular fragment peptides of mouse prostaglandin E2 receptor mEP3b isoform.2007
    • Author(s)
      Shinbo S., Yano Y., Oishi S., Fujii N., Sugimoto Y., Matsuzaki K.
    • Organizer
      44th Japanese Peptide Symposium
    • Place of Presentation
      Toyama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Development of GPR54 agonists as anti-metastasis agents.2007
    • Author(s)
      Tomita K., Oishi S., Ohno H., Akamatsu M., Fujii N.
    • Organizer
      The 8th workshop for cancer research for young scientists
    • Place of Presentation
      Tateshina
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Development of novel CXCR4 antagonist having an indole scaffold2007
    • Author(s)
      Katoh M., Ueda S., Inuki S., Oishi S., Ohno H., Fujii N.
    • Organizer
      The 57th Kinki Regional Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Osaka
    • Year and Date
      2007-10-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Unprecedented palladium- mediated carbon-fluorine bond cleavage : relevance to the synthesis of fluoroalkene dipeptidomimetics.2007
    • Author(s)
      Narumi T., Inokuchi E., Tomita K, Oishi S., Ohno H., Fujii N.
    • Organizer
      American Chemical Society 233rd National Meeting & Exposition
    • Place of Presentation
      Chicago
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] 情報から制御へ:ゲノム情報収斂型創薬科学2007
    • Author(s)
      藤井信孝
    • Organizer
      21COE公開シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2007-09-20
    • Data Source
      KAKENHI-PROJECT-18015027

  • [Presentation] Development of synthetic method for trifluoromethylalkene dipeptide isosteres by paradium-catalyzed carbonylation2007
    • Author(s)
      Inokuchi E., Narumi T., Niida A., Oishi S., Ohno H., Fujii N.
    • Organizer
      The 57th Kinki Regional Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Osaka
    • Year and Date
      2007-10-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Synthesis and applicatior of carbazoles by palladium-catalyzed tandem N-arylation and oxidative C-H activation.2007
    • Author(s)
      Watanabe T., Ueda S., Oishi S., Fujii N., Ohno H.
    • Organizer
      14th IUPAC Symposium on Organometallic Chemistry Directed Towards Organic Synthesis
    • Place of Presentation
      Nara
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Design and synthesis of novel HIV fusion inhibitors.2007
    • Author(s)
      Oishi S., Ito S., Nishikawa H., Tanaka M., Ohno H., Otaka A., Izumi K., Kodama E., Matsuoka M., Fujii N.
    • Organizer
      Virus Molecular Interactions : Therapeutic Targets
    • Place of Presentation
      Oxford
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Synthesis and application of Z-alkene and E-fluoroalkene dipeptide isosteres as cis-amide bond equivalents2007
    • Author(s)
      Tomita K., Narumi T., Niida A., Oishi S., Ohno H., Fujii N.
    • Organizer
      The 26th Symposium on Medicinal Chemistry
    • Place of Presentation
      Sagamihara
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres : Lys-Lys and Glu-Glu type FADIs.2007
    • Author(s)
      Narumi T., Kodera Y., Tomita K., Inokuchi E., Oishi S., Ohno H., Fujii N.
    • Organizer
      234th ACS meeting & exposition
    • Place of Presentation
      Boston
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] CXCR4 Antagonists; Relevance to Cancer Chemotherapy.2007
    • Author(s)
      Nobutaka Fujii
    • Organizer
      6th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      Istanbul
    • Year and Date
      2007-07-11
    • Data Source
      KAKENHI-PROJECT-18060020

  • [Presentation] Development of cyclic pentapeptide- based CXCR4 antagonists for the treatment of CXCR4-mediated diseases.2007
    • Author(s)
      Ueda S., Oishi S., Wang Z., Ohno H., Peiper SC, Fujii N.
    • Organizer
      First JCA-AACR Special Joint Conference : The Latest Advances in Lung Cancer Research : From Basic Science to Therapeutics
    • Place of Presentation
      Nagoya
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Development and application of novel photo-labile protecting groups (2) : One-pot coupling reactions of peptide fragments for chemical synthesis of membrane proteins2006
    • Author(s)
      Ogawa T., Ueda S., Tomita K, Otaka A., Fujii N.
    • Organizer
      The 126th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Sendai
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Drug Discovery for GPCR: From information to controls2006
    • Author(s)
      Fujii N.
    • Organizer
      The 269th Symposium of CBI society
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-11-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Preparation of peptide thioester utilizing S-protected oxazolidinone derived from cysteine.2006
    • Author(s)
      Otaka A., Ohta Y., Shigenaga A., Fujii N.
    • Organizer
      The 1lth Korea-Japan Joint Symposium on Drug Design and Development
    • Place of Presentation
      Cheju
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Synthesis of fluoroalkenes by paradium-catalyzed C-F bond cleavage2006
    • Author(s)
      Narumi T., Tomita K., Inokuchi E., Oishi S., Ohno H., Fujii N.
    • Organizer
      The 32th Symposium on Progress in Organic Reactions in the Life Sciences
    • Place of Presentation
      Hiroshima
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Structureactivity relationship study on GPR54 agonists.2006
    • Author(s)
      Tomita K., Niida A., Oishi S., Ohno H., Akamatsu M., Fujii N.
    • Organizer
      ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] From information to controls2006
    • Author(s)
      Fujii N.
    • Organizer
      The 7th Nagai Nagayoshi Memorial Symposium
    • Place of Presentation
      Tokushima
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Structure-activity relationship studies on cyclic peptide-based CXCK4 antagonists.2006
    • Author(s)
      eda S., Oishi S., Wang Z., Araki T., Tamamura H., Ohno H., NakashimaH., Peiper SC, Fujii N.
    • Organizer
      ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Development of small-molecule CXCR4 antagonists2006
    • Author(s)
      Tamamura H., Mizogami T., Hiramatsu K., Ogawa T., Ueda S., Tsutsumi H., Masuno H., Yamamoto N., Fujii N.
    • Organizer
      The 126th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Sendai
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Kegio- and stereoselective synthesis of (Z)-alkene cis-Xaa-Pro dipeptide mimetics with organocopper- mediated anti-SN2'2006
    • Author(s)
      Yoshikazu Sasaki, Takashi Tsuji, Ayumu Niida, Akira Shigenaga, Nobutaka Fujii, Akira Otaka
    • Organizer
      29th European Peptide Symposium
    • Place of Presentation
      Gdansk
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Discovery of novel low-molecular-weight GPR54 agonists.2006
    • Author(s)
      Shinya Oishi, Kenji Tomita, Ayumu Niida, Miki Akamatsu, Toshihiko Masui, Ryuichiro Doi, Jean-Marc Navenot, Zixang Wang, Stephen C. Peiper, Nobutaka Fujii
    • Organizer
      29th European Peptide Symposium
    • Place of Presentation
      Gdansk
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Diastereoselective synthesis of (Z)-fluoroalkene dipeptide isosteres based on organocopper-mediated reduction/direct alkylation via transmetalation.2006
    • Author(s)
      Tetsuo Narumi, Kenji Tomita, Ayumu Niida, Shinya Oishi, Hiroaki Ohno, Nobutaka Fujii
    • Organizer
      29th European Peptide Symposium
    • Place of Presentation
      Gdansk
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Structure-activity relationship studies on GPR54 agonists2006
    • Author(s)
      Tomita K., Oishi S., Ohno H., Akamatsu M., Fujii N.
    • Organizer
      The International Conference of 43rd Japanese Peptide Symposium and 4th Peptide Engineering Meeting
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] From amino acids to peptide isosteres : Implication to genome-lead drug discovery.2006
    • Author(s)
      Fujii N.
    • Organizer
      2nd Intermational Symposium on Biomolecules and Related Compounds
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] GPCR創薬 : 情報から制御へ2006
    • Author(s)
      藤井信孝
    • Organizer
      第269回CBI研究会講演会
    • Place of Presentation
      東京
    • Year and Date
      2006-11-01
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Development of chemokine receptor CXCR4 antagonists having bivalent Zn-complex structure2006
    • Author(s)
      Ogawa T., Tamamura H., Ojida A., Tsutsumi H., Masuno H., Nakajima H., Yamamoto N., Oishi S., Ohno H., Hamachi I., Fujii N.
    • Organizer
      The 56th Kinki Regional Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-10-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Synthesi of calbazoles by paradium-mediated tandem N-arylation and C-H activation2006
    • Author(s)
      Watanabe T., Ueda S., Oishi S., Fujii N., Ohno H.
    • Organizer
      The 56th Kinki Regional Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-10-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Synthesis of carbazoles by paradium-catalyzed tandem N-arylation and C-H activation2006
    • Author(s)
      Watanabe T., Ueda S., Oishi S., Fujii N., Ohno H.
    • Organizer
      The 23rd Seminars on Organic Chemistry
    • Place of Presentation
      Onuma
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] From amino acids to peptide isosteres : Implications to peptide-lead drug templates for genome-lead drug discovery.2006
    • Author(s)
      Nobutaka Fujii, Shinya Oishi, Tetsuo Narumi, Kenji Tomita, Hiroaki Ohno
    • Organizer
      232nd American Chemical Society National Meeting & Exposition
    • Place of Presentation
      San Francisco
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Novel synthesis of fluoroalkene isosteres utilizing paradium-catalyzed cleavage of C-F bond activation2006
    • Author(s)
      Narumi T., Niida A., Tomita K., Oishi S., Otaka A., Ohno H., Fujii N.
    • Organizer
      The 126th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Sendai
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Development of synthetic methodology toward (Z)-fluoro- alkene dipeptide isosteres based on the concept of organometalic-mediated C-F bond cleavage.2006
    • Author(s)
      Tetsuo Narumi, Kenji Tomita, Ayumu Niida, Yasuyo Kodera, Shinya Oishi, Hiroaki Ohno, Nobutaka Fujii
    • Organizer
      ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Synthesis of (Z)-alkene-containing Pro dipeptide isosteres corresponding to cis-prolyl peptides2006
    • Author(s)
      Sasaki Y., Niida A., Tsuji T., Shigenaga A., Fujii N., Otaka A.
    • Organizer
      The 1lth Korea-Japan Joint Symposium on Drug Design and Development
    • Place of Presentation
      Cheju
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] One-pot synthesis of carbazoles using paradium-catalyzed tandem N-arylation and C-H activation2006
    • Author(s)
      Watanabe T., Ueda S., Oishi S., Fujii N., Ohno H.
    • Organizer
      The 7th Nagai Nagayoshi Memorial Symposium
    • Place of Presentation
      Tokushima
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] From amino acids to peptide isosteres and heterocycles : implications to vinylaziri- dines and amino allene chemistry.2006
    • Author(s)
      Hiroaki Ohno, Tetsuaki Tanaka, Nobutaka Fujii
    • Organizer
      11th Akabori conference
    • Place of Presentation
      Regensburg
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Allylic hydrodefluorination under palladium catalysis for the synthesis of fluoroalkene dipeptide isosteres.2006
    • Author(s)
      Narumi T., Tomita K., Inokuchi E., Oishi S., Ohno H., Fujii H.
    • Organizer
      The 10th International KYOTO Conference on New Aspects of Organic Chemistry
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Synthesis of 2-(aminomethyl)indoles by organocopper-catalyzed three-component coupling2006
    • Author(s)
      Ohta Y., Oishi S., Fujii N., Ohno H.
    • Organizer
      The 56th Kinki Regional Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-10-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] From amino acids to peptide isosteres : Implications to peptide-lead drugtemplates for genome-lead drug discovery2006
    • Author(s)
      Nobutaka Fujii, et al.
    • Organizer
      232nd American Chemical Society National Meeting & Exposition
    • Place of Presentation
      サンフランシスコ
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Drag discovery targeting for 7TM-GPCRs2006
    • Author(s)
      Fujii N.
    • Organizer
      The 126th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Sendai
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Regio- and stereo-selective cis-Xaa-Pro-type (Z)-alkene dipeptide isosteres using organometal reagents2006
    • Author(s)
      Sasaki Y., Tsuji T., Niida A., Fujii N., Otaka A.
    • Organizer
      The 126th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Sendai
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Development of highly potent HIV fusion inhibitors based on EK-concept2006
    • Author(s)
      Itoh S., Oishi S., Nishikawa H., Tanaka M., Izumi K., Kodama E., Matsuoki M., Ohno H., Fujii N.
    • Organizer
      The 25th Symposium on Medicinal Chemistry
    • Place of Presentation
      Nagoya
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Synthesi and application of cis-amide equivalent alkene dipeptide isosteres2006
    • Author(s)
      Oishi S., Niida A., Narumi T., Tomita K., Inokuchi E., Ohno H., Kitaura K., Fujii N., Otaka A., Inui K.
    • Organizer
      The 32th Symposium on Progress in Organic Reactions in the Life Sciences
    • Place of Presentation
      Hiroshima
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Structure-activity relationship study on novel CXCR4 antagonists having a cyclic scaffold2006
    • Author(s)
      Watanabe T., Esaka R., Ogawa T., Ueda S., Tamamura H., Oishi S., Trent, JO., Wang, Z., Peiper, SC. Fujii N.
    • Organizer
      The 126th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Sendai
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Development of novel antiviral agents against T-20 registant HIV2006
    • Author(s)
      Itoh S., Oishi S., Nishikawa H., Tanaka M., Izumi K., Kodama E., Matsuoka M., Ohno H., Fujii N.
    • Organizer
      The 56th Kinki Regional Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-10-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Development of novel CXCR4 antagonists having bivalent Zn-complexes2006
    • Author(s)
      Ogawa T., Tamamura H., Ojida A., Tsutsumi H., Nakajima H., Oishi S., Ohno H., Hamachi I., Fujii N.
    • Organizer
      The 25th Symposium on Medicinal Chemistry
    • Place of Presentation
      Nagoya
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] A novel oxazolidine linker for the synthesis of peptide aldehydes.2006
    • Author(s)
      Tanaka M., Oishi S., Ohno H., Fujii N.
    • Organizer
      The International Conference of 43rd Japanese Peptide Symposium and 4th Peptide Engineering Meeting
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Development of chemical probes for the chemokine receptor CXCR4 involving radiolabeled T140 anglogs.2006
    • Author(s)
      Tamamura H., Hanaoka H., Tsutsumi H., Ohashi N., Tanaka T., Mori T., Mukai T., Doi R., Saji H., Fujii N.
    • Organizer
      The International Conference of 43rd Japanese Peptide Symposium and 4th Peptide Engineering Meeting
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] New peptide design for HIV-1 fusion inhibitors against T-20resistant HIV-1 variants.2006
    • Author(s)
      Nishikawa H., Kodama E., Ito S., Kajiwara K., Izumi K., Oishi S., Matsuoka M., Fujii N.
    • Organizer
      The 3rd Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
    • Place of Presentation
      Seoul
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Establishment anc clinical application of an enzyme immunoassay for metastin to determination of the human plasma levels.2006
    • Author(s)
      Katagiri F., Tomita K., Oishi S., Takeyama M., Fujii N.
    • Organizer
      The International Conference of 43rd Japanese Peptide Symposium and 4th Peptide Engineering Meeting
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209004

  • [Presentation] Development of a novel photo-labile protecting group having 4(dimethylamino)phenacyl group and the application to peptide synthesis2006