MITSUYA HIROAKI 満屋裕明

… Alternative Names

MITSUYA Hiroaki 満屋裕明

MITUYA Yoshiaki 満屋裕明

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Researcher Number	20136724
Other IDs
Affiliation (Current)	2025: 熊本大学, 病院, 特別招聘教授 2025: 国立健康危機管理研究機構, 国立国際医療研究所, 所長
Affiliation (based on the past Project Information) *help	2024: 国立研究開発法人国立国際医療研究センター, その他部局等, 研究所長 2017 – 2022: 国立研究開発法人国立国際医療研究センター, その他部局等, 研究所長 2016: 熊本大学, 医学部附属病院, 特別招聘教授 2015: 熊本大学, その他の研究科, 教授 2012 – 2015: 熊本大学, 大学院生命科学研究部, 教授 … More 2013: 熊本大学, 大学院生命科学研究部科, 教授 2009 – 2012: Kumamoto University, 大学院・生命科学研究部, 教授 2008: Kumamoto University, 大学院・医学薬学研究部, 教授 2005: 熊本大学, 大学院医学薬学研究部, 教授 2003 – 2004: Kumamoto University, Faculty of Medical and Pharmaceutical Sciences, Professor, 大学院・医学薬学研究部, 教授 1998 – 2002: 熊本大学, 医学部, 教授 Less
Review Section/Research Field	Principal Investigator Infectious disease medicine / Biological Sciences / Basic Section 54030:Infectious disease medicine-related / 膠原病・アレルギー・感染症内科学 / Medium-sized Section 53:Organ-based internal medicine and related fields / Pathology, Infection/Immunology, and related fields / 内科学一般 Except Principal Investigator Biological Sciences / 内科学一般
Keywords	Principal Investigator 薬剤耐性 / HIV / HIV-1 / プロテアーゼ阻害剤 / AIDS / エイズ / CCR5阻害剤 / ケモカイン / 結晶構造解析 / 創薬 … More / 感染症 / CCR5 / 新規抗HIV-1剤開発 / 二量体化阻害 / プロテアーゼ / in vivo imaging / HIVmcherry / humanizedマウス / HIV蛋白の自壊 / HIV酵素二量体化阻害剤 / 多剤耐性 / メインプロテアーゼ(Mpro)阻害剤 / SARS-CoV-2 / インテグラーゼ阻害剤 / 新規抗HBV剤の開発 / HBVキャプシド阻害剤 / 薬剤耐性HBV変異株 / 慢性B型肝炎 / HBV / ハロゲン結合 / 阻害剤開発 / 薬物動態 / CYP3A4 / ウイルス / 表面プラズモン法 / 動的解析 / 薬剤耐性機構 / 作用機序 / 質量分析 / 熱安定性 / 二量体化阻害剤 / AIDS/HIV-1 / CCR5 inhibitor / protease inhibitor / reverse taranscriptase / multi drug resistance / LD78β / spirodiketopiperazine誘導体 / Gaq / 逆転写酵素阻害剤 / 薬剤耐性メカニズム / 薬剤開発 / 相互作用解析 / 新規抗HIV剤 / 構造解析 / 新薬開発 / 新規薬剤の開発 / BiFC法 / IN多量体阻害 / HIVインテグラーゼ（IN） / 新規薬剤開発 / HIVプロテアーゼ / ESI-MS / 新規抗 HIV 剤開発 / AIDS(エイズ) / 単球/樹状細胞 / 抗HIV薬 / HIV初期感染病態 / 感染症治療学 / HIVプロテアーゼ二量体 / HIV感染症治療薬開発 / 持続産生細胞 / possible sanctuary / in vivo imaging法 / raltegravir / HIV初期感染動態 / HIVmC / hNOJマウス / リンパ節腫脹 / 新規抗HIV化合物 / コロニーアッセイ / 逆転写酵素 / 造血幹細胞 / 血液疾患 / 併用効果 / HIV感染 / bis-THF derivative / 組み換えHIVクローン / Cp-THF / bix-THF / X線結晶構造解析 / Gag / AK602 / E913 / AK60 / ケモカインレセプター阻害剤 … More Except Principal Investigator HIV-1 / 薬剤耐性 / Reverse transcriptase inhibitor / Neutralizing antibody / Vpr transgenic mouse / Membrane fusion inhibitor / CXCR4 inhibitor / Drug resistance / CCR5 inhibitor / Protease inhibitor / u-CRM1 / rev / フィットネス / 転写制御 / tat / CTL / 抗ウイルス剤 / 発症予防ワクチン / ケモカインレセプター阻害剤 / hu-PBL-SCIDマウス / 遺伝子発現制御 / トランスジェニックマウス / CXCR4拮抗剤 / T140 / 逆転写酵素阻害剤 / 中和抗体 / Vprトランスジェニックマウス / 膜融合阻害剤 / CXCR4阻害剤 / CCR5阻害剤 / プロテアーゼ阻害剤 / Chemokine Receptor / Chemokine / AIDS Control / Immune response / Pathophysiology / Host Factors / 抗HIV剤 / 抗HIV免疫 / コレセプター / HIV複製 / エイズ / ケモカイン受容体 / ケモカイン / 制御 / 免疫 / 病態 / 宿主因子 / インムノスクリーニング / cDNAライブリー / 脈絡膜 / 自己抗原 / 自己抗体 / HLAクラスII分子 / Vogt-小柳-原田病 / 自己免疫疾患 Less

ハロゲン修飾を介したブースター不要抗COVID-19治療薬のデザイン・合成と臨床開発Principal Investigator
- Principal Investigator
  
  満屋裕明
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  National Center for Global Health and Medicine
Development of a long-acting halogenated HBV capsid inhibitor that is potent against drug-resistant HBV mutantsPrincipal Investigator
- Principal Investigator
  
  Mitsuya Hiroaki
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  National Center for Global Health and Medicine
Study of mechanism of HIV resistance to integrase strand transfer inhibitors (INSTI) aiming at development of INSTI-resistance-repellant therapeuticsPrincipal Investigator
- Principal Investigator
  
  MITSUYA Hiroaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  National Center for Global Health and Medicine
Protease inhibitors exerting potent activity against wild type and multi-drug resistant HIV-1 variants without boosters.Principal Investigator
- Principal Investigator
  
  Mitsuya Hiroaki
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Pathology, Infection/Immunology, and related fields
- Research Institution
  National Center for Global Health and Medicine
Development of Halogen-Containing Compounds Potent against Wild-type and Multidrug-Resistant HIV-1 StrainsPrincipal Investigator
- Principal Investigator
  
  Hiroaki Mitsuya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  National Center for Global Health and Medicine
Elucidation of the mechanism of HIV-1's drug resistance against protease inhibitors using crystal structure and thermodynamic analysesPrincipal Investigator
- Principal Investigator
  
  MITSUYA Hiroaki
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kumamoto University
Development of Novel HIV-1 Protease Dimerization Inhibitors Using Crystal Structure, Thermal Stability and Mass Spectrum AnalysesPrincipal Investigator
- Principal Investigator
  
  Mitsuya Hiroaki
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kumamoto University
The molecular mechanism of HIV-1's drug resistance against protease inhibitors including darunavir and the development of novel resistance-repelling protease inhibitorsPrincipal Investigator
- Principal Investigator
  
  MITSUYA Hiroaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kumamoto University
Structural analysis of HIV integrase multimerization and development of inhibitors of integrase interactions with cellular cofactosPrincipal Investigator
- Principal Investigator
  
  MITSUYA Hiroaki
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kumamoto University
The analysis of HIV-protease dimerization mechanism at atomic andmolecular resolution, and the design of novel dimerization inhibition compounds.Principal Investigator
- Principal Investigator
  
  MITSUYA Hiroaki
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kumamoto University
Elucidation of the Emergence of HIV-1 Variants Resistant to HIV-1 Protease Dimerization Inhibitors (PDIs) and Development of Novel, Potent PDIsPrincipal Investigator
- Principal Investigator
  
  MITSUYA Hiroaki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kumamoto University
Analysis of the early phase dynamics of HIV-1 infection in hPBM-transplanted SCID mice using infectious HIV-1 carrying fluorescent protein mCherry and changes with anti HIV drug administrationPrincipal Investigator
- Principal Investigator
  
  MITSUYA Hiroaki
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kumamoto University
赤色蛍光発光HIVとその感染細胞の生体内播種・感染拡大の分子イメージング動態解析Principal Investigator
- Principal Investigator
  
  満屋裕明
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kumamoto University
HIVとHIV感染細胞の生体内播種と感染拡大ダイナミックスの分子イメージング解析Principal Investigator
- Principal Investigator
  
  満屋裕明
- Project Period (FY)
  2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kumamoto University
Study of generation and dynamics of HIV enzymes essential for replication and structural design of their inhibitorsPrincipal Investigator
- Principal Investigator
  
  MITSUYA Hiroaki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kumamoto University
感染細胞内でHIVコンポーネントの自壊をもらたす機序の解明とその誘導剤の研究Principal Investigator
- Principal Investigator
  
  満屋裕明
- Project Period (FY)
  2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kumamoto University
HIV感染症での血液幹細胞異常と新規抗HIV剤の影響の解析と対応策の研究・開発Principal Investigator
- Principal Investigator
  
  満屋裕明
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kumamoto University
新規のCCR5阻害剤の同定・開発とCCR5を介したHIV感染の分子機構の解明Principal Investigator
- Principal Investigator
  
  満屋裕明
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
CCR5を標的とした新規の抗HIV剤の基礎的研究と開発Principal Investigator
- Principal Investigator
  
  満屋裕明
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
耐「薬剤耐性」プロテアーゼ阻害剤(抗HIV剤)の基礎研究と開発Principal Investigator
- Principal Investigator
  
  満屋裕明
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kumamoto University
CCR5を標的とした新規の抗HIV剤の基礎的研究と開発Principal Investigator
- Principal Investigator
  
  満屋裕明
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Basic Research for AIDS control
- Principal Investigator
  
  UCHIYAMA Takashi
- Project Period (FY)
  2002
- Research Category
  
  特定領域研究
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Design, identification and development of novel antiviral agents active against HIVPrincipal Investigator
- Principal Investigator
  
  MITSUYA Hiroaki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  内科学一般
- Research Institution
  Kumamoto University
日本人の自己免疫疾患に特有のHLAクラスII・自己抗原ペプチド複合体の解析
- Principal Investigator
  
  西村泰治
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  内科学一般
- Research Institution
  Kumamoto University
Basic Research for AIDS control A03 ; Prevention and control of AIDS
- Principal Investigator
  
  MATSUSHITA Shuzo
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  KUMAMOTO UNIVERSITY

[Book] HIV/AIDS最近の治療. 臨牀と研究2016
- Author(s)
  服部真一朗、服部京子、満屋裕明
- Total Pages
  7
- Publisher
  大同学館出版部
- Data Source
  KAKENHI-PROJECT-16K15520
[Book] Development of the first AIDSdrugs: AZT and other dideoxynucleosides.In Human Immunodeficiency Virus ReverseTranscriptase2013
- Author(s)
  Yarchoan, R. and Mitsuya, H., A
- Publisher
  Bench-to-Bedside Success (S.F.J. Le Griceand M. Goette, eds.), Springer Publishing,New York
- Data Source
  KAKENHI-PROJECT-24659484
[Journal Article] Structural features in common of HBV and HIV-1 resistance against chirally-distinct nucleoside analogues entecavir and lamivudine.2020
- Author(s)
  Yasutake Y, Hattori SI, Tamura N, Matsuda K, Kohgo S, Maeda K, Mitsuya H.
- Journal Title
  
  Sci Rep.
  
  Volume: 10 Issue: 1 Pages: 3021-3021
- DOI
  10.1038/s41598-020-59775-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04222
[Journal Article] Novel Protease Inhibitors Containing C-5-Modified bis-Tetrahydrofuranylurethane and Aminobenzothiazole as P2 and P2′ Ligands That Exert Potent Antiviral Activity against Highly Multidrug-Resistant HIV-1 with a High Genetic Barrier against the Emergence of Drug Resistance2019
- Author(s)
  Yuki Takamatsu, Manabu Aoki, Haydar Bulut, Debananda Das, Masayuki Amano, Venkata Reddy Sheri, Ladislau C. Kovari, Hironori Hayashi, Nicole S. Delino, Arun K. Ghosh, Hiroaki Mitsuya.
- Journal Title
  
  Antimicrobial Agents and Chemotherapy.
  
  Volume: 63 Issue: 8 Pages: 1-1
- DOI
  10.1128/aac.00372-19
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08435, KAKENHI-PROJECT-19K17921, KAKENHI-PROJECT-17H04222, KAKENHI-PROJECT-19H03701
[Journal Article] Potent HIV-1 protease inhibitors incorporating squaramide-derived P2 ligands: Design, synthesis, and biological evaluation.2019
- Author(s)
  Ghosh AK, Williams JN, Kovela S, Takayama J, Simpson HM, Walters DE, Hattori SI, Aoki M, Mitsuya H.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 29 Issue: 18 Pages: 2565-2570
- DOI
  10.1016/j.bmcl.2019.08.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04222
[Journal Article] Potent HIV-1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein-Ligand X-ray Structural Studies.2019
- Author(s)
  Ghosh AK, Xia Z, Kovela S, Robinson WL, Johnson ME, Kneller DW, Wang YF, Aoki M, Takamatsu Y, Weber IT, Mitsuya H.
- Journal Title
  
  Chem Med Chem.
  
  Volume: 14 Issue: 21 Pages: 1863-1872
- DOI
  10.1002/cmdc.201900508
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04222
[Journal Article] Novel Central Nervous System (CNS)-Targeting Protease Inhibitors for Drug-Resistant HIV Infection and HIV-Associated CNS Complications2019
- Author(s)
  Masayuki Amano, Pedro Miguel Salcedo-Gomez, Ravikiran S. Yedidi, Rui Zhao, Hironori Hayashi, Kazuya Hasegawa, Tomofumi Nakamura, Cuthbert D. Martyr, Arun K. Ghosh, Hiroaki Mitsuya.
- Journal Title
  
  Antimicrobial Agents and Chemotherapy.
  
  Volume: 63 Issue: 7 Pages: 1-1
- DOI
  10.1128/aac.00466-19
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08435, KAKENHI-PROJECT-19K17921, KAKENHI-PROJECT-17H04222, KAKENHI-PROJECT-19H03701
[Journal Article] Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI) (GRL-001-15 and GRL-003-15) with the Flap of Protease Are Critical for Their Potent Activity against Wild-Type HIV-1 and Multi-PI-Resistant Variants2019
- Author(s)
  Hattori Shin-ichiro、Hayashi Hironori、Bulut Haydar、Rao Kalapala Venkateswara、Nyalapatla Prasanth R.、Hasegawa Kazuya、Aoki Manabu、Ghosh Arun K.、Mitsuya Hiroaki
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 63 Issue: 6 Pages: 1-1
- DOI
  10.1128/aac.02635-18
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17921, KAKENHI-PROJECT-17H04222, KAKENHI-PROJECT-19H03701
[Journal Article] Amino-acid inserts of HIV-1 capsid (CA) induce CA degradation and abrogate viral infectivity: Insights for the dynamics and mechanisms of HIV-1 CA decomposition.2019
- Author(s)
  Masayuki Amano, Haydar Bulut, Sadahiro Tamiya, Tomofumi Nakamura, Yasuhiro Koh, Hiroaki Mitsuya.
- Journal Title
  
  Scientific Reports.
  
  Volume: 9 Issue: 1 Pages: 9806-9806
- DOI
  10.1038/s41598-019-46082-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08435, KAKENHI-PROJECT-17H04222
[Journal Article] Mechanism of Darunavir (DRV)'s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance.2018
- Author(s)
  Aoki M, Das D, Hayashi H, Aoki-Ogata H, Takamatsu Y, Ghosh AK, Mitsuya H.
- Journal Title
  
  MBio.
  
  Volume: 9(2) Issue: 2
- DOI
  10.1128/mbio.02425-17
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04222, KAKENHI-PROJECT-17K19577, KAKENHI-PROJECT-17K15710
[Journal Article] Design and Synthesis of Potent HIV-1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure-Activity Studies and Biological and X-ray Structural Studies.2018
- Author(s)
  Ghosh AK, Williams JN, Ho RY, Simpson HM, Hattori SI, Hayashi H, Agniswamy J, Wang YF, Weber IT, Mitsuya H.
- Journal Title
  
  J Med Chem.
  
  Volume: 61(21) Issue: 21 Pages: 9722-9737
- DOI
  10.1021/acs.jmedchem.8b01227
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04222, KAKENHI-PROJECT-17K19577, KAKENHI-PROJECT-17K15710
[Journal Article] HIV-1 with HBV-associated Q151M substitution in RT becomes highly susceptible to entecavir: structural insights into HBV-RT inhibition by entecavir.2018
- Author(s)
  Yasutake Y, Hattori SI, Hayashi H, Matsuda K, Tamura N, Kohgo S, Maeda K, Mitsuya H.
- Journal Title
  
  Sci Rep.
  
  Volume: 8(1) Issue: 1 Pages: 1624-1624
- DOI
  10.1038/s41598-018-19602-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19577, KAKENHI-PROJECT-17H04222, KAKENHI-PROJECT-16K08826, KAKENHI-PROJECT-17K15710
[Journal Article] Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants.2018
- Author(s)
  Ghosh AK, Rao KV, Nyalapatla PR, Kovela S, Brindisi M, Osswald HL, Sekhara Reddy B, Agniswamy J, Wang YF, Aoki M, Hattori SI, Weber IT, Mitsuya H.
- Journal Title
  
  Chem Med Chem.
  
  Volume: 13(8) Issue: 8 Pages: 803-815
- DOI
  10.1002/cmdc.201700824
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04222, KAKENHI-PROJECT-17K19577
[Journal Article] GRL-079, a novel P2-Tp-THF-C5-alkylamine- and P2' -Abt-containing HIV-1 protease inhibitor, is extremely potent against multi-drug-resistant HIV-1 variants including HIVDRVRp51 and has a high genetic barrier against the emergence of resistant variants.2018
- Author(s)
  Delino NS, Aoki M, Hayashi H, Hattori SI, Chang SB, Takamatsu Y, Martyr CD, Das D, Ghosh AK, Mitsuya H.
- Journal Title
  
  Antimicrob Agents Chemother.
  
  Volume: 62(5) Issue: 5 Pages: 02060-17
- DOI
  10.1128/aac.02060-17
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19577, KAKENHI-PROJECT-17H04222, KAKENHI-PROJECT-17K15710
[Journal Article] Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands.2018
- Author(s)
  Ghosh AK, Jadhav RD, Simpson H, Kovela S, Osswald H, Agniswamy J, Wang YF, Hattori SI, Weber IT, Mitsuya H.
- Journal Title
  
  Eur J Med Chem.
  
  Volume: 160 Pages: 171-182
- DOI
  10.1016/j.ejmech.2018.09.046
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04222, KAKENHI-PROJECT-17K19577
[Journal Article] GRL-09510, a Unique P2-Crown-Tetrahydrofuranylurethane -Containing HIV-1 Protease Inhibitor, Maintains Its Favorable Antiviral Activity against Highly-Drug-Resistant HIV-1 Variants in vitro.2017
- Author(s)
  Masayuki Amano, Pedro Miguel Salcedo-Gomez, Ravikiran S. Yedidi, Nicole S. Delino, Hirotomo Nakata, Kalapala Venkateswara Rao, Arun K. Ghosh, Hiroaki Mitsuya.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 12235-12235
- DOI
  10.1038/s41598-017-12052-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09574, KAKENHI-PROJECT-17K19577, KAKENHI-PROJECT-17H04222
[Journal Article] Design, synthesis, biological evaluation, and X-ray studies of HIV-1 protease inhibitors with modified P2'-ligands of Darunavir.2017
- Author(s)
  Arun K Ghosh, W. Sean Fyvie, Margherita Brindisi, Melinda Steffey, Johnson Agniswamy, Yuan-Fang Wang, Manabu Aoki, Masayuki Amano, Irene T. Weber, Hiroaki Mitsuya.
- Journal Title
  
  ChemMedChem
  
  Volume: 12 Issue: 23 Pages: 1942-1952
- DOI
  10.1002/cmdc.201700614
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09574, KAKENHI-PROJECT-17K19577, KAKENHI-PROJECT-17H04222
[Journal Article] Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1′-P2′ ligands2017
- Author(s)
  Arun K. Ghosh, W. Sean Fyvie, Margherita Brindisi, Melinda Steffey, Johnson Agniswamy, Yuan-Fang Wang, Manabu Aoki, Masayuki Amano, Irene T. Weber, Hiroaki Mitsuya
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 27 Issue: 21 Pages: 4925-4931
- DOI
  10.1016/j.bmcl.2017.09.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09574, KAKENHI-PROJECT-17K19577, KAKENHI-PROJECT-17H04222
[Journal Article] Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants.2017
- Author(s)
  Ghosh AK, Rao KV, Nyalapatla PR, Osswald HL, Martyr CD, Aoki M, Hayashi H, Agniswamy J, Wang YF, Bulut H, Das D, Weber IT, Mitsuya H.
- Journal Title
  
  J Med Chem.
  
  Volume: 60(10) Issue: 10 Pages: 4267-4278
- DOI
  10.1021/acs.jmedchem.7b00172
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19577, KAKENHI-PROJECT-17K15710, KAKENHI-PROJECT-17H04222
[Journal Article] Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.2017
- Author(s)
  Arun K. Ghosh , Margherita Brindisi, Prasanth R. Nyalapatla, Jun Takayama, Jean-Rene Ella-Menye, Sofiya Yashchuk, Johnson Agniswamy, Yuan-Fang Wang, Manabu Aoki, Masayuki Amano, Irene T. Weber, Hiroaki Mitsuya
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 25 Issue: 19 Pages: 5114-5127
- DOI
  10.1016/j.bmc.2017.04.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09574, KAKENHI-PROJECT-17K19577, KAKENHI-PROJECT-17H04222
[Journal Article] A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency.2017
- Author(s)
  Aoki M, Hayashi H, Rao KV, Das D, Higashi-Kuwata N, Bulut H, Aoki-Ogata H, Takamatsu Y, Yedidi RS, Davis DA, Hattori SI, Nishida N, Hasegawa K, Takamune N, Nyalapatla PR, Osswald HL, Jono H, Saito H, Yarchoan R, Misumi S, Ghosh AK, Mitsuya H.
- Journal Title
  
  Elife
  
  Volume: 6
- DOI
  10.7554/elife.28020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19577, KAKENHI-PROJECT-17K15710, KAKENHI-PROJECT-17H04104, KAKENHI-PROJECT-17H04222
[Journal Article] Development and validation of a cell-based assay system to assess human immunodeficiency virus type 1 integrase multimerization.2016
- Author(s)
  Nakamura T, Campbell JR, Moore AR, Otsu S, Aikawa H, Tamamura H, Mitsuya H
- Journal Title
  
  J Virol Methods.
  
  Volume: 236 Pages: 196-206
- DOI
  10.1016/j.jviromet.2016.07.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293239, KAKENHI-PROJECT-16K15520
[Journal Article] A Modified P1 Moiety Enhances In Vitro Antiviral Activity against Various Multidrug-Resistant HIV-1 Variants and In Vitro Central Nervous System Penetration Properties of a Novel Nonpeptidic Protease Inhibitor, GRL-10413.2016
- Author(s)
  Amano M, Salcedo-Gomez PM, Zhao R, Yedidi RS, Das D, Bulut H, Delino NS, Sheri VR, Ghosh AK, Mitsuya H
- Journal Title
  
  Antimicrob Agents Chemother.
  
  Volume: 60(12) Pages: 7046-7059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293239
[Journal Article] Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV-1 Protease Inhibitors: Design, Synthesis, Protein X-ray Structural Studies, and Biological Evaluation.2016
- Author(s)
  Ghosh AK, Osswald HL, Glauninger K, Agniswamy J, Wang YF, Hayashi H, Aoki M, Weber IT, Mitsuya H
- Journal Title
  
  J Med Chem.
  
  Volume: 59(14) Issue: 14 Pages: 6826-37
- DOI
  10.1021/acs.jmedchem.6b00639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293239, KAKENHI-PROJECT-16K15520
[Journal Article] A Modified P1 Moiety Enhances In Vitro Antiviral Activity against Various Multidrug-Resistant HIV-1 Variants and In Vitro Central Nervous System Penetration Properties of a Novel Nonpeptidic Protease Inhibitor, GRL-10413.2016
- Author(s)
  Amano M, Salcedo-Gomez PM, Zhao R, Yedidi RS, Das D, Bulut H, Delino NS, Sheri VR, Ghosh AK, Mitsuya H
- Journal Title
  
  Antimicrob Agents Chemother.
  
  Volume: 60(12) Pages: 7046-7059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15520
[Journal Article] Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine(EFdA).2016
- Author(s)
  Salie ZL, Kirby KA, Michailidis E, Marchand B, Singh K, Rohan LC, Kodama EN, Mitsuya H, Parniak MA, Sarafianos SG.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 113 Issue: 33 Pages: 9274-9276
- DOI
  10.1073/pnas.1605223113
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05346, KAKENHI-PROJECT-26293239, KAKENHI-PROJECT-16K15520
[Journal Article] Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation, and Protein–Ligand X-ray Studies.2015
- Author(s)
  Ghosh, AK., Martyr, CD., Osswald, HL., Sheri, VR., Kassekert, LA., Chen, S., Agniswamy, J., Wang, YF., Hayashi, H., Aoki, M., Weber, IT., and Mitsuya, H.
- Journal Title
  
  J Med Chem
  
  Volume: 58 Issue: 17 Pages: 6994-7006
- DOI
  10.1021/acs.jmedchem.5b00900
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15382, KAKENHI-PROJECT-26293239
[Journal Article] C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir2015
- Author(s)
  Aoki, M. Hayashi, H. Yedidi, R. S. Martyr, C. D. Takamatsu, Y. Aoki-Ogata, H. Nakamura, T. Nakata, H. Das, D. Yamagata, Y. Ghosh, A. K. Mitsuya, H.
- Journal Title
  
  Journal of Virology
  
  Volume: 90 Issue: 5 Pages: 2180-94
- DOI
  10.1128/jvi.01829-15
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461510, KAKENHI-PROJECT-15K15382, KAKENHI-PROJECT-26293239
[Journal Article] Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands.2015
- Author(s)
  Arun K. Ghosh, Jun Takayama, Luke A. Kassekert, Jean-Rene Ella-Menye, Sofiya Yashchuk, Johnson Agniswamy, Yuan-Fang Wang, Manabu Aoki, Masayuki Amano, Irene T. Weber, Hiroaki Mitsuya.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 25 Issue: 21 Pages: 4903-4909
- DOI
  10.1016/j.bmcl.2015.05.052
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09574, KAKENHI-PROJECT-15K15382, KAKENHI-PROJECT-26293239
[Journal Article] Design of gem-Difluoro-bis-Tetrahydrofuran as P2 Ligand for HIV-1 Protease Inhibitors to Improve Brain Penetration: Synthesis, X-ray Studies, and Biological Evaluation.2015
- Author(s)
  Arun K. Ghosh, Sofiya Yashchuk, Akira Mizuno, Nilanjana Chakraborty, Johnson Agniswamy, Yuan-Fang Wang, Manabu Aoki, Pedro Miguel Salcedo Gomez, Masayuki Amano, Irene T. Weber, Hiroaki Mitsuya.
- Journal Title
  
  ChemMedChem
  
  Volume: 10 Issue: 1 Pages: 107-115
- DOI
  10.1002/cmdc.201402358
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09574, KAKENHI-PROJECT-15K15382, KAKENHI-PROJECT-26293239
[Journal Article] A NOVEL TRICYCLIC LIGAND-CONTAINING NONPEPTIDIC HIV-1 PROTEASE INHIBITOR, GRL-0739, EFFECTIVELY INHIBITS THE REPLICATION OF MULTI-DRUG-RESISTANT HIV-1 VARIANTS AND HAS A DESIRABLE CENTRAL NERVOUS SYSTEM (CNS) PENETRATION PROPERTY IN VITRO2015
- Author(s)
  Masayuki Amano, Yasushi Tojo, Pedro Miguel Salcedo-Gómez, Garth L. Parham, Prasanth R. Nyalapatla, Debananda Das, Arun K. Ghosh and Hiroaki Mitsuya
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 59 Issue: 5 Pages: 2625-2635
- DOI
  10.1128/aac.04757-14
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293239, KAKENHI-PROJECT-15K09574, KAKENHI-PROJECT-15K15382
[Journal Article] Conserved hydrogen-bonding network of P2 bis-tetrahydrofuran containing HIV-1 protease inhibitors (PI) with protease active site amino acid-backbone aid in their activity against PI-resistant HIV.2014
- Author(s)
  Yedidi RS, Garimella H, Aoki M, Aoki H, Desai DV, Chang SB, Davis DA, Fyvie WS, Kaufman JD, Smith DW, Das D, Wingfield PT, Maeda K, Ghosh AK and Mitsuya H.
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 58 Issue: 7 Pages: 3679-88
- DOI
  10.1128/aac.00107-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791031, KAKENHI-PROJECT-26293239
[Journal Article] Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir.2014
- Author(s)
  Hayashi H, Takamune N, Nirasawa T, Aoki M, Morishita Y, Das D, Koh Y, Ghosh AK, Misumi S, Mitsuya H.
- Journal Title
  
  Proc. Natl. Acad. Sci. U S A.
  
  Volume: 111 Issue: 33 Pages: 12234-9
- DOI
  10.1073/pnas.1400027111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590161, KAKENHI-PROJECT-24791031, KAKENHI-PROJECT-26293239
[Journal Article] Comparative analysis of ER stress response into HIV protease inhibitors : Lopinavir but not Darunavir induces potent ER stress response via ROS/JNK pathway.2013
- Author(s)
  Taura M, Kariya R, Kudo E, Goto H, Iwawaki T, Amano M, Suico MA, Kai H, Mitsuya H, Okada S.
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 65 Pages: 778-788
- DOI
  10.1016/j.freeradbiomed.2013.08.161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J08328, KAKENHI-PROJECT-23390265, KAKENHI-PROJECT-24390049
[Journal Article] GRL-04810 AND GRL-05010; DIFLUORIDE-CONTAINING NONPEPTIDIC HIV-1 PROTEASE INHIBITORS (PIs) THAT INHIBIT THE REPLICATION OF MULTI-PI-RESISTANT HIV-1 IN VITRO AND POSSESS FAVORABLE LIPOPHILICITY THAT MAY ALLOW BLOOD-BRAIN BARRIER PENETRATION2013
- Author(s)
  Gomez PMS, Amano M, Yashchuk S, Mizuno A, Das D, Ghosh, AK and Mitsuya H
- Journal Title
  
  Antimicrob. Agents Chemother
  
  Volume: 57 Issue: 12 Pages: 6110-6121
- DOI
  10.1128/aac.01420-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390265
[Journal Article] Highly Potent HIV-1 Protease Inhibitors with Novel Tricyclic P2 Ligands : Design, Synthesis, and Protein- Ligand X-ray Studies2013
- Author(s)
  Ghosh A, Partham GL, Martyr CD, Nyalapatla PR, Osswald HL, Agniswamy J, Wang YF, Amano M, Weber IT, Mitsuya H
- Journal Title
  
  J. Med. Chem
  
  Volume: 56 Issue: 17 Pages: 6792-6802
- DOI
  10.1021/jm400768f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390265
[Journal Article] GRL-0519, a Novel Oxatricyclic Ligand-Containing Nonpeptidic HIV-1 Protease Inhibitor (PI), Potently Suppresses Replication of a Wide Spectrum of Multi-PI-Resistant HIV-1 Variants In Vitro, Antimicrob2013
- Author(s)
  Amano M, Tojo Y, Gomez PMS, Campbell JR, Das D, Aoki M, Xu CX, Rao KV, Ghosh AK, and Mitsuya H
- Journal Title
  
  Agents Chemother
  
  Volume: 57 Issue: 5 Pages: 2036-2046
- DOI
  10.1128/aac.02189-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390265, KAKENHI-PROJECT-23791140, KAKENHI-PROJECT-24659484, KAKENHI-PROJECT-24791031
[Journal Article] Effect oftranslocation defective reversetranscriptase inhibitors on theactivity of n348i, a connectionsubdomain drug resistant HIV-1 reversetranscriptase mutant.2012
- Author(s)
  Michailidis E, Singh K, Ryan EM,Hachiya A, Ong YT, Kirby KA, MarchandB, Kodama EN, Mitsuya H, Parniak MA,Sarafianos SG
- Journal Title
  
  Cell. Mol. Biol
  
  Volume: 58 Pages: 187-195
- URL
  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551986/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659484
[Journal Article] Mechanism of interaction of humanmitochondrial DNA polymerase γ withthe novel nucleoside reversetranscriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine indicates alow potential for host toxicity2012
- Author(s)
  Sohl, C.D., Singh, K., Kasiviswanathan,R., Copeland, W.C., Mitsuya, H.,Sarafianos, S.G., Anderson, K.S
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 56 Issue: 3 Pages: 1630-1634
- DOI
  10.1128/aac.05729-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659484
[Journal Article] Biochemical, inhibition, and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase.2012
- Author(s)
  Tanyaradzwa P. Ei-Ichi Kodama, et al.
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 40 Issue: 1 Pages: 345-359
- DOI
  10.1093/nar/gkr694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590636, KAKENHI-PROJECT-24659484
[Journal Article] Loss of the Protease Dimerization Inhibition Activity of Tipranavir (TPV) and Its Association with the Acquisition of Resistance to TPV by HIV-1.2012
- Author(s)
  Manabu Aoki, Matthew L. Danish, Hiromi Aoki-Ogata, Masayuki Amano, Kazuhiko Ide, Debananda Das, Yasuhiro Koh, and Hiroaki Mitsuya
- Journal Title
  
  Journal of Virology.
  
  Volume: 86 Pages: 13384-13396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390265
[Journal Article] Response of simianimmunodeficiency virus to the novelnucleoside reverse transcriptaseinhibitor4'-ethynyl-2-fluoro-2'-deoxyadenosine in vitro and in vivo.2012
- Author(s)
  Murphey-Corb, M., Rajakuma, P.,Michael., H., Nyaundi, J., Didier,P.J., Reeve, A.B., Mitsuya, H.,Sarafianos, S.G., and Parniak MA
- Journal Title
  
  AntimicrobAgents Chemother.
  
  Volume: 56 Issue: 9 Pages: 4707-4712
- DOI
  10.1128/aac.00723-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659484
[Journal Article] Substituent effects on P2-cyclopentyltetrahydrofuranyl urethanes: Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors.2012
- Author(s)
  Ghosh AK, Chapsal BD, Steffey M, Agniswamy J, Wang YF, Amano M, Weber IT, Mitsuya H.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters.
  
  Volume: 22 Pages: 2308-2311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390265
[Journal Article] Enhancing protein backbone binding--a fruitful concept for combating drug-resistant HIV.2012
- Author(s)
  Ghosh AK, Anderson DD, Weber IT, Mitsuya H.
- Journal Title
  
  Angewandte Chemie International Edition in English
  
  Volume: 51 Pages: 1778-1802
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390265
[Journal Article] Enhancing protein backbone binding- -a fruitful concept for combating drugresistant HIV2012
- Author(s)
  Ghosh AK, Anderson DD, Weber IT, Mitsuya H
- Journal Title
  
  Angewandte Chemie International Edition in English
  
  Volume: 51 Issue: 8 Pages: 1778-1802
- DOI
  10.1002/anie.201102762
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390265, KAKENHI-PROJECT-24659484
[Journal Article] Substituent effects on P2-cyclopentyltetrahydrofuranyl urethanes : Design, synthesis, and X- ray studies of potent HIV- 1 protease inhibitors2012
- Author(s)
  Ghosh AK, Chapsal BD, Steffey M, Agniswamy J, Wang YF, Amano M, Weber IT, Mitsuya H
- Journal Title
  
  Bioorganic &Medicinal Chemistry Letters
  
  Volume: 22 Issue: 6 Pages: 2308-2311
- DOI
  10.1016/j.bmcl.2012.01.061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390265, KAKENHI-PROJECT-23791140, KAKENHI-PROJECT-24659484
[Journal Article] Balancing antiviralpotency and host toxicity: identifyinga nucleotide inhibitor with an optimalkinetic phenotype for HIV-1 reversetranscriptase.2012
- Author(s)
  Sohl, C.D., Kasiviswanathan, R., Kim,J., Pradere, U., Schinazi, R.F.,Copeland, W.C., Mitsuya, H., Baba, M.,Anderson, K.S.
- Journal Title
  
  Mol Pharmacol
  
  Volume: 82 Issue: 1 Pages: 125-133
- DOI
  10.1124/mol.112.078758
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659484
[Journal Article] Loss of the Protease Dimerization Inhibition Activity of Tipranavir (TPV) and Its Association with the Acquisition of Resistance to TPV by HIV- 12012
- Author(s)
  Manabu Aoki, Matthew L. Danish, Hiromi Aoki- Ogata, Masayuki Amano, Kazuhiko Ide, Debananda Das, Yasuhiro Koh, and Hiroaki Mitsuya
- Journal Title
  
  Journal of Virology
  
  Volume: 86 Issue: 24 Pages: 13384-13396
- DOI
  10.1128/jvi.07234-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390265, KAKENHI-PROJECT-23791140, KAKENHI-PROJECT-24659484, KAKENHI-PROJECT-24791031
[Journal Article] CCR5 inhibitors:emergence, success, and challenges2012
- Author(s)
  Maeda, K., Das, D. Nakata, H., andMitsuya, H
- Journal Title
  
  Expert Opin Emerging Drugs
  
  Volume: 17 Issue: 2 Pages: 135-145
- DOI
  10.1517/14728214.2012.673584
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659484
[Journal Article] Substituent effects on P2-cyclopentyltetrahydrofuranyl urethanes : Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors2012
- Author(s)
  Arun K.Ghosh, Bruno D.Chapsal, Melinda Steffey, Johnson Agniswamy, Yuan-Fang Wang, Masayuki Amano, Irene T.Weber, Hiroaki Mitsuya
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 22 Pages: 2308-2311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390265
[Journal Article] Novel HIV-1 Protease Inhibitors (PIs) Containing a Bicyclic P2 Functional Moiety, Tetrahydropyrano- Tetrahydrofuran, That Are Potent against Multi-PI -Resistant HIV-1 Variants.2011
- Author(s)
  Ide K, Aoki M, Amano M, Koh Y, Yedidi RS, Das D, Leschenko S, Chapsal B, Ghosh AK, Mitsuya H
- Journal Title
  
  Antimicrob Agents Chemother.
  
  Volume: 55 Pages: 1717-1787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Novel HIV-1 Protease Inhibitors (PIs) Containing a Bicyclic P2 Functional Moiety, Tetrahydropyrano- Tetrahydrofuran, That Are Potent against Multi-PI-Resistant HIV-1 Variants.2011
- Author(s)
  Ide K, Aoki M, Amano M, Koh Y, Yedidi RS, Das D, Leschenko S, Chapsal B, Ghosh AK, Mitsuya H
- Journal Title
  
  Antimicrob Agents Chemother.
  
  Volume: 55 Pages: 1717-1787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659189
[Journal Article] Design of Substituted Bis-tetrahydrofuran (Bis-THF)-Derived Potent HIV-1 Protease Inhibitors, Protein-Ligand X-ray Structure, and Convenient Syntheses of Bis-THF and Substituted Bis-THF Ligands2011
- Author(s)
  Arun K. Ghosh, Cuthbert D. Martyr, Melinda Steffey, Yuan-Fang Wang, Johnson Agniswamy, Masayuki Amano, Irene T. Weber, Hiroaki Mitsuya
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 2 Pages: 298-302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390265
[Journal Article] Design, Synthesis, and X-ray Structure of Substituted bis-tetrahydrofuran (bis-THF)- Derived Potent HIV-1 Protease Inhibitors.2011
- Author(s)
  Ghosh AK, Martyr CD, Steffey M, Wang YF, Agniswamy J, Amano M, Weber IT, Mitsuya H
- Journal Title
  
  ACS Med.Chem.Lett.
  
  Volume: 2 Pages: 298-302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659189
[Journal Article] Design of HIV-1 Protease Inhibitors with C3-Substituted Hexahydrocy clopentafuranyl Urethane as P2-Ligands : Synthesis, Biological Evaluations, and Protein-Ligand X-ray Crystal Structure2011
- Author(s)
  Arun K.Ghosh, Bruno D.Chapsal, Garth L.Parham, Melinda Steffey, Johnson Agniswamy, Yuan-Fang Wang, Masayuki Amano, Irene T.Weber, Hiroaki Mitsuya
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 54 Pages: 5890-5901
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390265
[Journal Article] Design and synthesis of potent HIV-1 protease inhibitors incorporating Hexahydrofuropyranol-derived high affinity P(2)ligands : structure-activity studies and biological evaluation.2011
- Author(s)
  Ghosh AK, Chapsal BD, Baldridge A, Steffey MP, Walters DE, Koh Y, Amano M, Mitsuya H
- Journal Title
  
  J Med Chem.
  
  Volume: 27;54(2) Pages: 622-634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Design, Synthesis, and X-ray Structure of Substituted bis-tetrahydrofuran (bis-THF)-Derived Potent HIV-1 Protease Inhibitors.2011
- Author(s)
  Ghosh AK, Martyr CD, Steffey M, Wang YF, Agniswamy J, Amano M, Weber IT, Mitsuya H
- Journal Title
  
  ACS Med.Chem.Lett.
  
  Volume: 2 Pages: 298-302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Novel HIV-1 Protease Inhibitors (PIs) Containing a Bicyclic P2 Functional Moiety, Tetrahydropyrano-Tetrahydrofuran, That Are Potent against Multi-PI-Resistant HIV-1 Variants.2011
- Author(s)
  Ide K, Aoki M, Amano M, Koh Y, Yedidi RS, Das D, Leschenko S, Chapsal B, Ghosh AK, Mitsuya H
- Journal Title
  
  Antimicrob Agents Chemother. 55
  
  Pages: 1717-1787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Design, Synthesis, and X-ray Structure of Substituted bis-tetrahydrofuran (bis-THF)- Derived Potent HIV-1 Protease Inhibitors.2011
- Author(s)
  Ghosh AK, Martyr CD, Steffey M, Wang YF, Agniswamy J, Amano M, Weber IT, Mitsuya H
- Journal Title
  
  ACS Med.Chem.Lett 2
  
  Pages: 298-302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Design and synthesis of potent HIV-1 protease inhibitors incorporating Hexahydrofuropyranolderived high affinity P(2) ligands : structure-activity studies and biological evaluation.2011
- Author(s)
  Ghosh AK, Chapsal BD, Baldridge A, Steffey MP, Walters DE, Koh Y, Amano M, Mitsuya H.
- Journal Title
  
  J Med Chem. 27;54(2)
  
  Pages: 622-634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Design and synthesis of potent HIV-1 protease inhibitors incorporating Hexahydrofuropyranol-derived high affinity P(2) ligands : structure-activity studies and biological evaluation.2011
- Author(s)
  Ghosh AK, Chapsal BD, Baldridge A, Steffey MP, Walters DE, Koh Y, Amano M, Mitsuya H
- Journal Title
  
  J Med Chem.
  
  Volume: 27;54(2) Pages: 622-634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659189
[Journal Article] Loss of Protease Dimerization Inhibition Activity of Darunavir Is Associated with the Acquisition of Resistance to Darunavir by HIV-12011
- Author(s)
  Yasuhiro Koh, Manabu Aoki, Matthew L. Danish, Hiromi Aoki-Ogata, Masayuki Amano, Debananda Das, Robert W. Shafer, Arun K. Ghosh, Hiroaki Mitsuya
- Journal Title
  
  Journal of Virology
  
  Volume: 85 Issue: 19 Pages: 10079-10089
- DOI
  10.1128/jvi.05121-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390265
[Journal Article] Design of HIV-1 Protease Inhibitors with C3-Substituted Hexahydrocyclopentafuranyl Urethane as P2-Ligands : Synthesis, Biological Evaluations, and Protein-Ligand X-ray Crystal Structure2011
- Author(s)
  Arun K. Ghosh, Bruno D. Chapsal, Garth L. Parham, Melinda Steffey, Johnson Agniswamy, Yuan-Fang Wang, Masayuki Amano, Irene T. Weber, Hiroaki Mitsuya
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 54 Issue: 16 Pages: 5890-5901
- DOI
  10.1021/jm200649p
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390265
[Journal Article] Design and Synthesis of Potent HIV-1 Protease Inhibitors Incorporating Hexahydrofuropyranol-Derived High Affinity P2 Ligands : Structure-Activity Studies and Biological Evaluation2011
- Author(s)
  Arun K.Ghosh, Bruno D.Chapsal, Abigail Baldridge, Melinda P.Steffey, D.Eric Walters, Yasuhiro Koh, Masayuki Amano, Hiroaki Mitsuya
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 54 Pages: 622-634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390265
[Journal Article] Loss of Protease Dimerization Inhibition Activity of Durunavir Is Associated with the Acquisition of Resistance to Darunavir by HIV-12011
- Author(s)
  Yasuhiro Koh, Manabu Aoki, Matthew L.Danish, Hiromi Aoki-Ogata, Masayuki Amano, Debananda Das, Robert W.Shafer, Arun K.Ghosh, Hiroaki Mitsuya
- Journal Title
  
  Journal of Virology
  
  Volume: 85 Pages: 10079-10089
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390265
[Journal Article] Novel HIV-1 protease inhibitors (PIs) containing a bicyclic P2 functional moiety, tetrahydropyrano-tetrahydrofuran, that are potent against multi-PI-resistant HIV-1 variants2011
- Author(s)
  Kazuhiko Ide, Manabu Aoki, Masayuki Amano, Yasuhiro Koh, Ravikiran S. Yedidi, Debananda Das, Sofiya Leschenko, Bruno Chapsal, Arun K. Ghosh, Hiroaki Mitsuya
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 55 Issue: 4 Pages: 1717-1727
- DOI
  10.1128/aac.01540-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390265
[Journal Article] Design and Synthesis of Potent HIV-1 Protease Inhibitors Incorporating Hexahydrofuropyranol -Derived High Affinity P2 Ligands2011
- Author(s)
  Arun K. Ghosh, Bruno D. Chapsal, Abigail Baldridge, Melinda P. Steffey, D. Eric Walters, Yasuhiro Koh, Masayuki Amano, Hiroaki Mitsuya
- Journal Title
  
  Structure-Activity Studies and Biological Evaluation
  
  Volume: 54 Issue: 2 Pages: 622-634
- DOI
  10.1021/jm1012787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390265
[Journal Article] Probing multidrug-resistance and protein-ligand interactions with oxatricyclic designed ligands in HIV-1 protease inhibitors.2010
- Author(s)
  Ghosh AK, Xu CX, Rao KV, Baldridge A, Agniswamy J, Wang YF, Weber IT, Aoki M, Miguel SG, Amano M, Mitsuya H
- Journal Title
  
  ChemMedChem.
  
  Volume: 5 Pages: 1850-1854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Probing multidrug-resistance and protein-ligand interactions with oxatricyclic designed ligands in HIV-1 protease inhibitors.2010
- Author(s)
  Ghosh AK, Xu CX, Rao KV, Baldridge A, Agniswamy J, Wang YF, Weber IT, Aoki M, Miguel SG, Amano M, Mitsuya H.
- Journal Title
  
  ChemMedChem. 5
  
  Pages: 1850-1854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] In vitro selection of highly darunavir-resistant and replication-competent HIV-1 variants using a mixture of clinical HIV-1 isolates resistant to multiple conventional protease inhibitors.2010
- Author(s)
  Koh Y, Amano M, Towata T, Danish M, Leshchenko-Yashchuk S, Das D, Nakayama M, Tojo Y, Ghosh AK, Mitsuya H
- Journal Title
  
  J Virol.
  
  Volume: 84 Pages: 11961-969
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Novel protease inhibitors (PIs) containing macrocyclic components and 3(R),3a(S),6a(R)-bis tetrahydrofuranylurethane that are potent against multi-PI-resistant HIV-1 variants in vitro.2010
- Author(s)
  Tojo Y, Koh Y, Amano M, Aoki M, Das D, Kulkarni S, Anderson DD, Ghosh AK, Mitsuya H.
- Journal Title
  
  Antimicrob Agents Chemother. 54
  
  Pages: 3460-3470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Novel protease inhibitors (PIs) containing macrocyclic components and 3(R), 3a(S), 6a(R)-bis- tetrahydrofuranylurethane that are potent against multi-PI-resistant HIV-1 variants in vitro.2010
- Author(s)
  Tojo Y, Koh Y, Amano M, Aoki M, Das D, Kulkarni S, Anderson DD, Ghosh AK, Mitsuya H
- Journal Title
  
  Antimicrob Agents Chemother.
  
  Volume: 54 Pages: 3460-3470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] In vitro selection of highly darunavir-resistant and replicationcompetent HIV-1 variants using a mixture of clinical HIV-1 isolates resistant to multiple conventional protease inhibitors.2010
- Author(s)
  Koh Y, Amano M, Towata T, Danish M, Leshchenko-Yashchuk S, Das D, Nakayama M, Tojo Y, Ghosh AK, Mitsuya H.
- Journal Title
  
  J Virol. 84
  
  Pages: 11961-11969
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Probing multidrug-resistance and protein-ligand interactions with oxatricyclic designed ligands in HIV-1 protease inhibitors.2010
- Author(s)
  Ghosh AK, Xu CX, Rao KV, Baldridge A, Agniswamy J, Wang YF, Weber IT, Aoki M, Miguel SG, Amano M, Mitsuya H
- Journal Title
  
  ChemMedChem.
  
  Volume: 5 Pages: 1850-1854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659189
[Journal Article] In vitro selection of highly darunavir-resistant and replication-competent HIV-1 variants using a mixture of clinical HIV-1 isolates resistant to multiple conventional protease inhibitors.2010
- Author(s)
  Koh Y, Amano M, Towata T, Danish M, Leshchenko-Yashchuk S, Das D, Nakayama M, Tojo Y, Ghosh AK, Mitsuya H
- Journal Title
  
  J Virol.
  
  Volume: 84 Pages: 11961-969
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659189
[Journal Article] Synthesis and biological evaluation of novel allophenyl-norsta tine-based HIV-1 protease inhibitors incorporating high affinity P2-ligands2010
- Author(s)
  Ghosh, AK, Mitsuya, H., et al.
- Journal Title
  
  Bioorg.Med.Chem.Lett 20
  
  Pages: 1241-1246
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Synthesis and biological evaluation of novel allophenylnorstatine-based HIV-1 protease inhibitors incorporating high affinity P2-ligands.2010
- Author(s)
  Ghosh AK, Gemma S, Simoni E, Baldridge A, Walters DE, Ide K, Tojo Y, Koh Y, Amano M, Mitsuya H
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 20 Pages: 1241-1246
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Effects of CCR5 Inhibitors on the Dynamics of CCR5 and CC-chemo kine-CCR5 interactions2010
- Author(s)
  Nakata, H., Mitsuya, H., et al.
- Journal Title
  
  Antiviral Therapy (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Synthesis and biological evaluation of novel allophenylnorstatine-based HIV-1 protease inhibitors incorporating high affinity P2-ligands.2010
- Author(s)
  Ghosh AK, Gemma S, Simoni E, Baldridge A, Walters DE, Ide K, Tojo Y, Koh Y, Amano M, Mitsuya H.
- Journal Title
  
  Bioorg Med Chem Lett. 20
  
  Pages: 1241-1246
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Novel protease inhibitors (PIs) containing macrocyclic components and 3(R), 3a(S), 6a(R)-bis- tetrahydrofuranylurethane that are potent against multi-PI-resistant HIV-1 variants in vitro.2010
- Author(s)
  Tojo Y, Koh Y, Amano M, Aoki M, Das D, Kulkarni S, Anderson DD, Ghosh AK, Mitsuya H
- Journal Title
  
  Antimicrob Agents Chemother.
  
  Volume: 54 Pages: 3460-3470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659189
[Journal Article] Synthesis and biological evaluation of novel allophenylnorstatine-based HIV-1 protease inhibitors incorporating high affinity P2-ligands.2010
- Author(s)
  Ghosh AK, Gemma S, Simoni E, Baldridge A, WaltersDE, Ide K, Tojo Y, Koh Y, Amano M, Mitsuya H
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 20 Pages: 1241-1246
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659189
[Journal Article] Design, Synthesis, Protein-Ligand X-ray Structure, and Biological Evaluation of a Series of Novel Macrocyclic Human Immunodeficiency Virus-1 Protease Inhibitors to Combat Drug Resistance.2009
- Author(s)
  Ghosh AK, Kulkarni S, Anderson DD, Hong L, Baldridge A, Wang YFChumanevich AA, Kovalevsky AY, Tojo Y, Amano M, Koh Y, Tang J, Weber IT, Mitsuya H.
- Journal Title
  
  J.Med.Chem. 52
  
  Pages: 7689-7705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Non-cleavage Site Gag Mutations in Amprenavir-resistant HIV-1 Predispose HIV-1 to Rapid Acquisition of Amprenavir Resistance But Delays Development of Resistance to Other Protease Inhibitors.2009
- Author(s)
  Aoki M, David JV, Koh Y, Aoki-Ogata H, Miyakawa T, Yoshimura K, Maeda K, Mitsuya H.
- Journal Title
  
  J Virol. 83
  
  Pages: 3059-3068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] P-glycoprotein mediates efflux transport of darunavir in human intestinal Caco-2 and ABCB1 gene-transfected renal LLC-PK1 cell lines2009
- Author(s)
  Fujimoto H, Mitsuya, H., et al.
- Journal Title
  
  Biol.Pharm.Bull. 32
  
  Pages: 1588-1593
- NAID
  130000117288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Design, synthesis, protein-ligand X-ray structures and biological evaluation of a series of novel macrocyclic HIV-1 protease inhibitors to combat drug-resistance2009
- Author(s)
  Ghosh, AK, Mitsuya, H., et al.
- Journal Title
  
  J.Med.Chem 52
  
  Pages: 7689-7705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Prediction of Potency of Protease Inhibitors Using Free Energy Simulations with Polarizable Quantum Mechanics-Based Ligand Charges and a Hybrid Water Model.2009
- Author(s)
  Das D, Koh Y, Tojo Y, Ghosh AK, Mitsuya H.
- Journal Title
  
  J.Chem.Inf.Model. 49
  
  Pages: 2851-2862
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Effects of CCR5 Inhibitors on the Dynamics of CCR5 and CC-chemokine-CCR5 interactions.2009
- Author(s)
  Nakata H, Kruhlak M, Kamata W, Ogata-Aoki H, Li J, Maeda K, Ghosh AK, Mitsuya H.
- Journal Title
  
  Antivir Ther. 15
  
  Pages: 321-331
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] GRL-02031 : A Novel Nonpeptidic Protease Inhibitor (PI) Containing A Stereochemically Defined Fused Cyclopentanyltetrahydrofuran (Cp-THF) Potent Against Multi-PI-Resistant HIV-1 In Vitro.2009
- Author(s)
  Koh Y, Das D, Leschenko S, Nakata H, Ogata-Aoki H, Amano M, Nakayama M, Ghosh AK, Mitsuya H.
- Journal Title
  
  Antimicrob Agents Chemother. 53
  
  Pages: 997-1006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Prediction of Potency of Protease Inhibitors Using Free Energy Simulations with Polarizable Quantum Mechanics-Based Ligand Charges and a Hybrid Water Model2009
- Author(s)
  Das D, Mitsuya, H., et al.
- Journal Title
  
  J.Chem.Inf.Model 49
  
  Pages: 2851-2862
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Synthesis and biological evaluation of novel allophenylnorstatine-based HIV-1 protease inhibitors incorporating high affinity P2-ligands.2009
- Author(s)
  Ghosh AK, Gemma S, Simoni E, Baldridge A, Walters DE, Ide K, Tojo Y, Koh Y, Amano M, Mitsuya H.
- Journal Title
  
  J.Med.Chem. 20
  
  Pages: 1241-1246
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Design of HIV-1 protease inhibitors with pyrrolidinones and oxazolidinones as novel Pl'-ligands to enhance backbone-binding interactions with protease : synthesis, biological evaluation, and protein-ligand X-ray studies2009
- Author(s)
  Ghosh, AK, Mitsuya, H., et al.
- Journal Title
  
  J.Med.Chem 52
  
  Pages: 3902-3914
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Mechanism of inhibition of HIV-1 reverse transcriptase by 4'-ethynyl-2-fluoro-deoxyadenosine triphosphate, a translocation defective reverse transcriptase inhibitor2009
- Author(s)
  Michailidis E, Mitsuya, H., et al.
- Journal Title
  
  J.Biol.Chem. 284
  
  Pages: 35681-35691
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Potent synergistic anti-human immunodeficiency virus (HIV) effects using combinations of the CCR5 inhibitor aplaviroc with other anti-HIV drugs.2008
- Author(s)
  Nakata H, Steinberg SM, Koh Y, Maeda K, Takaoka Y, Tamamura H, Fujii N, Mitsuya H.
- Journal Title
  
  Antimicrob Agents Chemother. 52
  
  Pages: 2111-2119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Design and Synthesis of Stereochemically Defined Novel Spirocyclic P2-Ligands for HIV-1 Protease Inhibitors.2008
- Author(s)
  Ghosh AK, Chapsal BD, Baldridge A, Ide K, Koh Y, Mitsuya H.
- Journal Title
  
  Org Lett. 10
  
  Pages: 5135-5138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Potent HIV-1 protease inhibitors incorporating meso-bicyclic urethanes as P2-ligands : structure-based design, synthesis, biological evaluation and protein-ligand X-ray studies.2008
- Author(s)
  Ghosh AK, Gemma S, Takayama J, Baldridge A, Leshchenko-Yashchuk S, Miller HB, Wang YF, Kovalevsky AY, Koh Y, Weber IT, Mitsuya H.
- Journal Title
  
  Org Biomol Chem. 6
  
  Pages: 3703-3713
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Flexible cyclic ethers/ polyethers as novel P2-ligands for HIV-1 protease inhibitors : design, synthesis, biological evaluation, and protein-ligand X-ray studies.2008
- Author(s)
  Ghosh AK, Gemma S, Baldridge A, Wang YF, 5 Kovalevsky AY, Koh Y, Weber IT, Mitsuya H.
- Journal Title
  
  J Med Chem. 51
  
  Pages: 6021-6033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Development of protease inhibitors and the fight with drug-resistant HIV-1 variants.2008
- Author(s)
  Mitsuya H, Maeda K, Das D, Ghosh AK.
- Journal Title
  
  Adv Pharmacol. 56
  
  Pages: 169-197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Involvement of the second extracellular loop and transmembrane residues of CCR5 in inhibitor binding and HIV-1 fusion : insights into the mechanism of allosteric inhibition.2008
- Author(s)
  Maeda K, Das D, Yin PD, Tsuchiya K, Ogata-Aoki H, Nakata H, Norman RB, Hackney LA, Takaoka Y, Mitsuya H.
- Journal Title
  
  J Mol Biol. 381
  
  Pages: 956-974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Development of protease inhibitors and the fight with drug-resistant HIV-1 variants.2008
- Author(s)
  Mitsuya H
- Journal Title
  
  Adv Pharmacol. 56
  
  Pages: 169-197
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Design of HIV protease inhibitors targeting protein backbone : an effective strategy for combating drug resistance.2008
- Author(s)
  Ghosh AK, Chapsal BD, Weber IT, Mitsuya H.
- Journal Title
  
  Acc Chem Res. 41
  
  Pages: 78-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390288
[Journal Article] Structural and molecular interactions of CCR5 inhibitors with CCR5.2006
- Author(s)
  Maeda, K., Mitsuya, H.et al.
- Journal Title
  
  J.Biol.Chem.(Published on-lin on February 13,2006)
- Data Source
  KAKENHI-PROJECT-17659302
[Journal Article] Overcoming HIV Drug Resistance through Rational Drug HIV Based on Molecular, Biochemical, and Structural Profiles of HIV Resistance.2006
- Author(s)
  Yin, P.D., Mitsuya, H.et al.
- Journal Title
  
  Cell Mol Life Sci. (In press)
- Data Source
  KAKENHI-PROJECT-17659302
[Journal Article] Altered HIV-1 gag protein interactions with cyclophilin A (CypA) on the acquisition of H219Q and H219P substitutions in the CypA binding loop.2006
- Author(s)
  Gatanaga, H., Mitsuya, H.et al.
- Journal Title
  
  J.Biol.Chem 281
  
  Pages: 1241-1250
- Data Source
  KAKENHI-PROJECT-17659302
[Journal Article] Design and synthesis of novel HIV-1 protease inhibitors incorporating oxyindoles as the P2'-ligands.2006
- Author(s)
  Ghosh, A.K., Mitsuya, H.et al.
- Journal Title
  
  Bioorg.Med.Chem.Lett. 76
  
  Pages: 1869-1873
- Data Source
  KAKENHI-PROJECT-17659302
[Journal Article] Increase of C1q biosynthesis in brain microglia and macrophages during lentivirus infection in the rhesus macaque is sensitive to antiretroviral treatment with 6-chloro-2',3' dideoxyguanosine.2005
- Author(s)
  Depboylu, C., Mitsuya, H.et al.
- Journal Title
  
  Neurobiol Dis 20
  
  Pages: 12-26
- Data Source
  KAKENHI-PROJECT-17659302
[Journal Article] Potent anti-R5-HIV-1 effects of a CCR5 antagonist AK602 in a novel hu-PBMC-non-obese diabetic-SCID, IL-2R γ-chain-knocked-out AIDS mouse model.2005
- Author(s)
  Nakata, H., H.Mitsuya, et al.
- Journal Title
  
  J Virol. 79
  
  Pages: 2087-2096
- Data Source
  KAKENHI-PROJECT-16017286
[Journal Article] Potent anti-R5 human immunodeficiency virus type 1 effects of a CCR5 antagonist, AK602/ONO4128/GW873140, in a novel human peripheral blood mononuclear cell nonobese diabetic-SCID, interleukin-2 receptor γ-chain-knocked-out AIDS mouse model.2005
- Author(s)
  Nakata, H., Mitsuya, H.et al.
- Journal Title
  
  J.Virol 79
  
  Pages: 2087-2096
- Data Source
  KAKENHI-PROJECT-17659302
[Journal Article] Spontaneous recovery of hemoglobin and neutrophil levels in Japanese patients on a long-term Combivir【○!R】 containing regimen.2005
- Author(s)
  Matsushita, S., Mitsuya, H.et al.
- Journal Title
  
  J.Clin.Virol 33
  
  Pages: 188-193
- Data Source
  KAKENHI-PROJECT-17659302
[Journal Article] Structure-Based Design : Synthesis and biological evaluation of a series of novel cycloamide-derived HIV-1 protease inhibitors. J Med Chem2005
- Author(s)
  Ghosh, A.K., Mitsuya, H.et al.
- Journal Title
  
  J Med Chem 48
  
  Pages: 3576-3585
- Data Source
  KAKENHI-PROJECT-17659302
[Journal Article] Potent anti-R5-HIV-1 effects of a CCR5 antagonist AK602 in a novel hu-PBMC-non-obese diabetic-SCID, IL-2R γ-chain-knocked-out AIDS mouse model.2005
- Author(s)
  Nakata, H., H.Mitsuya, et al.
- Journal Title
  
  J Virol. 79
  
  Pages: 2087-2096
- Data Source
  KAKENHI-PROJECT-15659237
[Journal Article] Identification of aberrantly methylated genes in association with adult T-cell leukemia.2004
- Author(s)
  Yasunaga, J., H.Mitsuya, et al.
- Journal Title
  
  Cancer Res. 64
  
  Pages: 6002-6009
- Data Source
  KAKENHI-PROJECT-16017286
[Journal Article] Attempt to reduce cytotoxicity by synthesizing the L-enantiomer of 4'-C-ethynyl-2'-deoxypurine nucleosides as antiviral agents against HIV and HBV.2004
- Author(s)
  Kitano, K., H.Mitsuya, et al.
- Journal Title
  
  Antivir.Chem.Chemother. 15
  
  Pages: 161-167
- Data Source
  KAKENHI-PROJECT-15659237
[Journal Article] Amino acid insertions near Gag cleavage sites restore the other-wise compromised replication of human immunodeficiency virus type 1 variants resistant to protease inhibitors.2004
- Author(s)
  Tamiya, S., H.Mitsuya, et al.
- Journal Title
  
  J Virol. 78
  
  Pages: 12030-12040
- Data Source
  KAKENHI-PROJECT-16017286
[Journal Article] Attempt to reduce cytotoxicity by synthesizing the L-enantiomer of 4'-C-ethynyl-2'-deoxypurine nucleosides as antiviral agents against HIV and HBV.2004
- Author(s)
  Kitano, K., H.Mitsuya, et al.
- Journal Title
  
  Antivir.Chem.Chemother. 15
  
  Pages: 161-167
- Data Source
  KAKENHI-PROJECT-16017286
[Journal Article] Spirodiketopiperazine-based CCR5 inhibitor which preserves CC-chemokine/CCR5 interactions and exerts potent activity against R5 human immuno-deficiency virus type 1 in vitro.2004
- Author(s)
  Maeda, K., H.Mitsuya, et al.
- Journal Title
  
  J Virol. 78
  
  Pages: 8654-8662
- Data Source
  KAKENHI-PROJECT-15659237
[Journal Article] The current status of, and challenges in, the development of CCR 5 inhibitors as therapeutics for HIV-1 infection.2004
- Author(s)
  Maeda, K., H.Mitsuya, et al.
- Journal Title
  
  Curr.Opin.Pharmacol. 4
  
  Pages: 447-452
- Data Source
  KAKENHI-PROJECT-15659237
[Journal Article] Amino acid insertions near Gag cleavage sites restore the other wise compromised replication of human immunodeficiency virus type 1 variants resistant to protease inhibitors.2004
- Author(s)
  Tamiya, S., H.Mitsuya, et al.
- Journal Title
  
  J Virol. 78
  
  Pages: 12030-12040
- Data Source
  KAKENHI-PROJECT-15659237
[Journal Article] Identification of aberrantly methylated genes in association with adult T-cell leukemia.2004
- Author(s)
  Yasunaga, J., H.Mitsuya, et al.
- Journal Title
  
  Cancer Res. 64
  
  Pages: 6002-6009
- Data Source
  KAKENHI-PROJECT-15659237
[Journal Article] Spirodiketopiperazine-based CCR5 inhibitor which preserves CC-chemokine/ CCR5 interactions and exerts potent activity against R5 human immuno-deficiency virus type 1 in vitro.2004
- Author(s)
  Maeda, K., H.Mitsuya, et al.
- Journal Title
  
  J Virol. 78
  
  Pages: 8654-8662
- Data Source
  KAKENHI-PROJECT-16017286
[Journal Article] The current status of, and challenges in, the development of CCR5 inhibitors as therapeutics for HIV-1 infection.2004
- Author(s)
  Maeda, K., H.Mitsuya, et al.
- Journal Title
  
  Curr.Opin.Pharmacol. 4
  
  Pages: 447-452
- Data Source
  KAKENHI-PROJECT-16017286
[Patent] HIV-1 PROTEASE INHIBITORS AND USES THEREOF2014
- Inventor(s)
  GHOSH A, RAO V, MITSUYA H
- Industrial Property Rights Holder
  Purdue U. & Kumamoto U.
- Industrial Property Rights Type
  特許
- Filing Date
  2014-05-16
- Acquisition Date
  2015-05-15
- Overseas
- Data Source
  KAKENHI-PROJECT-26293239
[Presentation] HIV-1プロテアーゼ阻害剤GRL-142は、インテグラーゼのNLSに結合、HIV-1DNAの核移行を阻害し、インテグラーゼ阻害剤耐性HIV-1変異体を強力に阻害する2022
- Author(s)
  青木学, 青木宏美, Haydar Bulut, 林宏典, 長谷川和也, Arun K Ghosh, Alice K. Pau, 満屋裕明
- Organizer
  第30回日本抗ウイルス療法学会
- Data Source
  KAKENHI-PROJECT-20H03727
[Presentation] GRL142 Binds to and Impairs HIV-1-Integrase-Nuclear Localizing Signal and Exerts Potent Activity against INSTI-Resistant HIV-12022
- Author(s)
  Manabu Aoki1, Hiromi Aoki-Ogata, Haydar Bulut1, Hironori Hayashi, Arun K. Ghosh, Alice K. Pau, and Hiroaki Mitsuya
- Organizer
  HIV DART 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03727
[Presentation] 新規プロテアーゼ阻害剤GRL-142は、インテグラーゼのNLSに結合、HIV-1DNAの核移行を阻害し、インテグラーゼ阻害剤耐性HIV-1変異体を強力に阻害する2022
- Author(s)
  青木学, 青木宏美, Haydar Bulut, 林宏典, 長谷川和也, Arun K Ghosh, Alice K. Pau, 満屋裕明
- Organizer
  第36回日本エイズ学会学術集会総会
- Data Source
  KAKENHI-PROJECT-20H03727
[Presentation] Discovery of Reverse Transcriptase Inhibitors for Treating HIV-1/AIDS2022
- Author(s)
  Hiroaki Mitsuya
- Organizer
  2022 Cold Spring Harbor biohistory meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03727
[Presentation] Long Time Scale Molecular Dynamics Reveal Mechanism of HIV’s High Resistance to Darunavir2019
- Author(s)
  Debananda Das, Manabu Aoki, Hironori Hayashi, Ravikiran Yedidi, Haydar Bulut, Arun K. Ghosh, Hiroaki Mitsuya
- Organizer
  第33回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17H04222
[Presentation] GRL-142とそのアナログの強力な抗ウイルス活性発揮機序の解明2019
- Author(s)
  服部真一朗, 林宏典, Haydar Bulut, 青木学, 長谷川和也, Arun K. Ghosh, 満屋裕明
- Organizer
  第29回抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17H04222
[Presentation] P2-bis-THF基およびP2'-CpAbt基を有し、多剤耐性HIV変異株に対しても強力な抗ウイルス活性を発揮する新規プロテアーゼ阻害薬の同定2019
- Author(s)
  高松悠樹、青木　学、Bulut Haydar、Das Debananda、天野将之、Sheri Venkata Reddy、Kovari Ladislau C.、林　宏典、Delino Nicole S.、Ghosh Arun K.、満屋裕明
- Organizer
  第33回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17H04222
[Presentation] HIVプロテアーゼ阻害剤GRL-142とその誘導体の強力な抗ウイルス活性発揮機序の解明2019
- Author(s)
  服部真一朗, Haydar Bulut, 林宏典, 青木学, 青木宏美, 長谷川和也, Arun K. Ghosh, 満屋裕明
- Organizer
  第33回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17H04222
[Presentation] 極めて強力な抗ウイルス活性を発揮する新規HIVプロテアーゼ阻害剤の同定とその機序2018
- Author(s)
  服部真一朗、林宏典、Bulut Haydar、長谷川和也、青木学、Ghosh Arun K.、満屋裕明
- Organizer
  第32回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17H04222
[Presentation] 多剤耐性HIV変異株にも強力な抗ウイルス活性を発揮する新規HIVプロテアーゼ阻害剤の同定とその機序2018
- Author(s)
  服部真一朗、林宏典、Haydar Bult、青木学、長谷川和也、Arun K. Ghosh、満屋裕明
- Organizer
  第28回抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K19577
[Presentation] 多剤耐性HIV変異株にも強力な抗ウイルス活性を発揮する新規HIVプロテアーゼ阻害剤の同定とその活性・構造相関2018
- Author(s)
  服部真一朗、林宏典、Haydar Bulut、Debananda Das、長谷川和也、青木学、Arun K. Ghosh、満屋裕明
- Organizer
  第20回白馬シンポジウム in 屋久島
- Data Source
  KAKENHI-PROJECT-17H04222
[Presentation] Discovery of an unprecedentedly potent HIV-1 protease inhibitor, GRL-0142, and its biological features.2018
- Author(s)
  Manabu Aoki, Nobuyo Higashi-Kuwata, Hiromi Aoki, Haydar Bulut, Debananda Das, Ruth M. Ruprecht, Arun K. Ghosh, Hiroaki Mitsuya,
- Organizer
  HIV DART & EMERGING VIRUSES
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04222
[Presentation] 多剤耐性HIV変異株にも強力な抗ウイルス活性を発揮する新規HIVプロテアーゼ阻害剤の同定とその機序2018
- Author(s)
  服部真一朗、林宏典、Haydar Bult、青木学、長谷川和也、Arun K. Ghosh、満屋裕明
- Organizer
  第28回抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17H04222
[Presentation] 6.A novel HIV protease inhibitor, GRL-142, binds to interase and potently blocks INSTI-resistant HIV-1 varients.2018
- Author(s)
  Manabu Aoki, Hydar Bulut, Yuki Takamatsu, Tomofumi Nakamura, Arun Ghosh, Hiroaki Mitsuya,
- Organizer
  HIV DART & EMERGING VIRUSES
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04222
[Presentation] Discovery of an unprecedentedly potent HIV-1 protease inhibitor, GRL-0142, and its biological features.2018
- Author(s)
  Manabu Aoki, Nobuyo Higashi-Kuwata, Hiromi Aoki, Haydar Bulut, Debananda Das, Ruth M. Ruprecht, Arun K. Ghosh, Hiroaki Mitsuya
- Organizer
  HIV DART & EMERGING VIRUSES
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19577
[Presentation] 極めて強力な抗ウイルス活性を発揮する新規HIVプロテアーゼ阻害剤の同定とその機序2018
- Author(s)
  服部真一朗、林宏典、Bulut Haydar、長谷川和也、青木学、Ghosh Arun K.、満屋裕明
- Organizer
  第32回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K19577
[Presentation] 多剤耐性HIV変異株にも強力な抗ウイルス活性を発揮する新規HIVプロテアーゼ阻害剤の同定とその活性・構造相関2018
- Author(s)
  服部真一朗、林宏典、Haydar Bulut、Debananda Das、長谷川和也、青木学、Arun K. Ghosh、満屋裕明
- Organizer
  第20回白馬シンポジウム in 屋久島
- Data Source
  KAKENHI-PROJECT-17K19577
[Presentation] 極めて強力な活性を有する新規HIV-1プロテアーゼ阻害剤GRL-142 /KU-241の同定及びその SIVmac251感染サルにおける抗SIV効果の検討2018
- Author(s)
  鍬田伸好, 青木学, Viraj Kulkarni, 服部真一朗, 青木宏美, 林宏典, 城野博史, 山川佑可子, 前田賢次, 刈谷龍昇, 岡田誠治, Arun K. Ghosh, Ruth M. Ruprecht, 満屋裕明,
- Organizer
  第20回白馬シンポジウム in 屋久島
- Data Source
  KAKENHI-PROJECT-17H04222
[Presentation] 極めて強力な活性を有する新規HIV-1プロテアーゼ阻害剤GRL-142 /KU-241の同定及びその SIVmac251感染サルにおける抗SIV効果の検討2018
- Author(s)
  鍬田伸好, 青木学, Viraj Kulkarni, 服部真一朗, 青木宏美, 林宏典, 城野博史, 山川佑可子, 前田賢次, 刈谷龍昇, 岡田誠治, Arun K. Ghosh, Ruth M. Ruprecht, 満屋裕明
- Organizer
  第20回白馬シンポジウム in 屋久島
- Data Source
  KAKENHI-PROJECT-17K19577
[Presentation] Antiviral activity of GRL-142 against SIVmac251 in Rhesus macaques.2018
- Author(s)
  Nobuyo Kuwata, Manabu Aoki, Viraj Kulkarni, Shin-ichiro Hattori, Hiromi Aoki, Ryusho Kariya, Hirofumi Jono, Yukako Yamakawa, Seiji Okada, Arun Ghosh, Ruth Ruprecht, Hiroaki Mitsuya,
- Organizer
  HIV DART & EMERGING VIRUSES
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04222
[Presentation] Antiviral activity of GRL-142 against SIVmac251 in Rhesus macaques.2018
- Author(s)
  Nobuyo Kuwata, Manabu Aoki, Viraj Kulkarni, Shin-ichiro Hattori, Hiromi Aoki, Ryusho Kariya, Hirofumi Jono, Yukako Yamakawa, Seiji Okada, Arun Ghosh, Ruth Ruprecht, Hiroaki Mitsuya
- Organizer
  HIV DART & EMERGING VIRUSES
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19577
[Presentation] A novel HIV protease inhibitor, GRL-142, binds to interase and potently blocks INSTI-resistant HIV-1 varients2018
- Author(s)
  Manabu Aoki, Hydar Bulut, Yuki Takamatsu, Tomofumi Nakamura, Arun Ghosh, Hiroaki Mitsuya
- Organizer
  HIV DART & EMERGING VIRUSES
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19577
[Presentation] 多剤耐性HIV変異株にも強力な抗ウイルス活性を発揮する新規HIVプロテアーゼ阻害剤の同定2017
- Author(s)
  服部真一朗、林宏典、青木学、長谷川和也、Haydar Bulut、Debananda Das、Arun Ghosh、満屋裕明
- Organizer
  第31回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17H04222
[Presentation] 4’-Modified NRTIs’ Potent Anti-HIV Activity Stems from Strong RT Active Site Binding.2017
- Author(s)
  Takamatsu Y, Das D, Kohgo S, Hattori S, Hayashi H, Matsuda K, Stefan G. Sarafianos SG, Mitsuya H, and Maeda K.
- Organizer
  2017 Conference on Retroviruses and Opportunistic Infections (CROI)
- Place of Presentation
  シアトル、アメリカ
- Year and Date
  2017-02-12
- Data Source
  KAKENHI-PROJECT-26293239
[Presentation] GRL-079, a novel P2-Tp-THF-C5-alkylamine- and P2’-Abt-containing HIV-1 protease inhibitor, is extremely potent against a wide spectrum of HIVMDRs including HIVDRVRp51 with a high genetic barrier against the emergence of resistant variants2017
- Author(s)
  Nicole S. Delino, Manabu Aoki, Hironori Hayashi, Shin-ichiro Hattori, Simon B. Chang, Yuki Takamatsu, Cuthbert D. Martyr, Debananda Das, Arun K. Ghosh, and Hiroaki Mitsuya
- Organizer
  第19回白馬シンポジウムin仙台
- Data Source
  KAKENHI-PROJECT-17H04222
[Presentation] GRL-079, a novel P2-Tp-THF-C5 alkylamine and P2’-Abt-containing HIV-1 protease inhibitor, is extremely potent against a wide spectrum of HIVMDRs, including HIVDRVRp51, with a high genetic barrier against the emergence of resistant variants2017
- Author(s)
  Nicole S. Delino, Aoki Manabu, Hayashi Hironori,Hattori Shin-ichiro, Simon B. Chang, Takamatsu Yuki, Cuthbert D. Martyr, Debananda Das, Arun K. Ghosh, and Mitsuya Hiroaki
- Organizer
  第31回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17H04222
[Presentation] P1-phenylにフッ素原子を導入したHIVプロテアーゼ阻害剤は強力な抗ウイルス活性を発揮する2017
- Author(s)
  服部真一朗、林宏典、青木学、Debananda Das、青木宏美、鍬田伸好、高松悠樹、Yedidi Ravikran、長谷川和也、Arun K Ghosh、前田賢次、満屋裕明
- Organizer
  第27回抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K19577
[Presentation] P2-Tp-THF-C5-alkylamine and P'2-Abt contribute to the potency of newly-generated protease inhibitors against a wide spectrum of HIVMDRS including HIVDRVRP512017
- Author(s)
  Nicole S. Delino, Manabu Aoki, Hironori Hayashi, Haydar Bulut, Shin-ichiro Hattori, Simon B. Chang, Yuki Takamatsu, Cuthbert D. Martyr, Debananda Das, Arun K. Ghosh, and Hiroaki Mitsuya,
- Organizer
  第27回抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K19577
[Presentation] GRL-079, a novel P2-Tp-THF-C5-alkylamine- and P2’-Abt-containing HIV-1 protease inhibitor, is extremely potent against a wide spectrum of HIVMDRs including HIVDRVRp51 with a high genetic barrier against the emergence of resistant variants,2017
- Author(s)
  Nicole S. Delino, Manabu Aoki, Hironori Hayashi, Shin-ichiro Hattori, Simon B. Chang, Yuki Takamatsu, Cuthbert D. Martyr, Debananda Das, Arun K. Ghosh, and Hiroaki Mitsuya,
- Organizer
  第19回白馬シンポジウムin仙台
- Data Source
  KAKENHI-PROJECT-17K19577
[Presentation] 多剤耐性HIV変異株に対して強力な抗ウイルス活性を発揮する新規HIVプロテアーゼ阻害剤、GRL-001～004の同定と構造・活性相関2017
- Author(s)
  服部真一朗、林宏典、青木学、長谷川和也、青木宏美、鍬田伸好、Haydar Bulut、Debananda Das、前田賢次、Arun K. Ghosh、満屋裕明
- Organizer
  第19回白馬シンポジウムin仙台
- Data Source
  KAKENHI-PROJECT-17H04222
[Presentation] GRL-079, a novel P2-Tp-THF-C5-alkylamine- and P2’-Abt-containing HIV-1 protease inhibitor, is extremely potent against a wide spectrum of multi-drug-resistant HIVs including HIVDRVRp51 and has a high genetic barrier against the emergence of resistant variants2017
- Author(s)
  Nicole S. Delino, Manabu Aoki, Hironori Hayashi, Shin-ichiro Hattori, Simon B. Chang, Yuki Takamatsu, Cuthbert D. Martyr, Debananda Das, Arun K. Ghosh, and Hiroaki Mitsuy
- Organizer
  第18回熊本エイズセミナー
- Data Source
  KAKENHI-PROJECT-17K19577
[Presentation] P1-phenylにフッ素原子を導入したHIVプロテアーゼ阻害剤は強力な抗ウイルス活性を発揮する2017
- Author(s)
  服部真一朗、林宏典、青木学、Debananda Das、青木宏美、鍬田伸好、高松悠樹、Yedidi Ravikran、長谷川和也、Arun K Ghosh、前田賢次、満屋裕明
- Organizer
  第27回抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17H04222
[Presentation] GRL-079, a novel P2-Tp-THF-C5-alkylamine- and P2’-Abt-containing HIV-1 protease inhibitor, is extremely potent against a wide spectrum of multi-drug-resistant HIVs including HIVDRVRp51 and has a high genetic barrier against the emergence of resistant variants2017
- Author(s)
  Nicole S. Delino, Manabu Aoki, Hironori Hayashi, Shin-ichiro Hattori, Simon B. Chang, Yuki Takamatsu, Cuthbert D. Martyr, Debananda Das, Arun K. Ghosh, and Hiroaki Mitsuya
- Organizer
  第18回熊本エイズセミナー
- Data Source
  KAKENHI-PROJECT-17H04222
[Presentation] 多剤耐性HIV変異株に対して強力な抗ウイルス活性を発揮する新規HIVプロテアーゼ阻害剤、GRL-001～004の同定と構造・活性相関2017
- Author(s)
  服部真一朗、林宏典、青木学、長谷川和也、青木宏美、鍬田伸好、Haydar Bulut、Debananda Das、前田賢次、Arun K. Ghosh、満屋裕明
- Organizer
  第19回白馬シンポジウムin仙台
- Data Source
  KAKENHI-PROJECT-17K19577
[Presentation] GRL-079, a novel P2-Tp-THF-C5 alkylamine and P2’-Abt-containing HIV-1 protease inhibitor, is extremely potent against a wide spectrum of HIVMDRs, including HIVDRVRp51, with a high genetic barrier against the emergence of resistant variants.2017
- Author(s)
  Nicole S. Delino, Aoki Manabu, Hayashi Hironori,Hattori Shin-ichiro, Simon B. Chang, Takamatsu Yuki, Cuthbert D. Martyr, Debananda Das, Arun K. Ghosh, and Mitsuya Hiroaki,
- Organizer
  第31回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K19577
[Presentation] 多剤耐性HIV変異株にも強力な抗ウイルス活性を発揮する新規HIVプロテアーゼ阻害剤の同定2017
- Author(s)
  服部真一朗、林宏典、青木学、長谷川和也、Haydar Bulut、Debananda Das、Arun Ghosh、満屋裕明,
- Organizer
  第31回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K19577
[Presentation] P2-Tp-THF-C5-alkylamine and P'2-Abt contribute to the potency of newly-generated protease inhibitors against a wide spectrum of HIVMDRS including HIVDRVRP512017
- Author(s)
  Nicole S. Delino, Manabu Aoki, Hironori Hayashi, Haydar Bulut, Shin-ichiro Hattori, Simon B. Chang, Yuki Takamatsu, Cuthbert D. Martyr, Debananda Das, Arun K. Ghosh, and Hiroaki Mitsuya
- Organizer
  第27回抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17H04222
[Presentation] HIV-1プロテアーゼのflap領域と相互作用する化合物はdarunavir高度耐性HIV-1を強力に阻害する2016
- Author(s)
  林宏典, 青木学, Yedidi Ravikiran, 中田浩智, Debananda Das, 中村照也, 長谷川和也, 山縣ゆり子, Arun K Ghosh, 満屋裕明
- Organizer
  第26回抗ウイルス療法学会総会
- Place of Presentation
  名古屋
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-16K15520
[Presentation] 本邦におけるHIV感染者・AIDS発症者数の動向とARTの医療経済的解析2016
- Author(s)
  尾又一実, 菊池嘉, 岡慎一, 満屋裕明. 本邦におけるHIV感染者・AIDS発症者数の動向とARTの医療経済的解析
- Organizer
  第26回抗ウイルス療法学会総会
- Place of Presentation
  名古屋
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-26293239
[Presentation] 新規抗HIV薬候補化合物KU-241のin vitro遺伝毒性・体内動態・脳組織内濃度2016
- Author(s)
  鍬田伸好, 青木学, 服部真一朗, 青木宏美, 林宏典, 前田賢次, Arun K. Ghosh, 満屋裕明
- Organizer
  第26回抗ウイルス療法学会総会
- Place of Presentation
  名古屋
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-16K15520
[Presentation] 極めて強力な抗HIV活性を有する新規HIV-1プロテアーゼ阻害剤、KU-2412016
- Author(s)
  服部真一朗, 青木学, 鍬田伸好, 林宏典, 青木宏美, 前田賢次, Arun K. Ghosh, 満屋裕明
- Organizer
  第30回日本エイズ学会学術集会・総会
- Place of Presentation
  鹿児島
- Year and Date
  2016-11-24
- Data Source
  KAKENHI-PROJECT-16K15520
[Presentation] Mechanism of unprecedentedly potent activity of KU-241 against various HIV-1 variants2016
- Author(s)
  Hayashi H., Aoki M., Hattori S., Higashi-Kuwata N., Yedidi RS., Ogata-Aoki H., Das D., Hasegawa K., Ghosh AK. and Mitsuya H.
- Organizer
  第15回あわじしま感染症・免疫フォーラム
- Place of Presentation
  兵庫
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-16K15520
[Presentation] 前例を見ないほど強力な抗HIV活性を示すKU-241の作用機序の解析2016
- Author(s)
  林宏典, 青木学, Debananda Das, 鍬田伸好, 青木宏美, 服部真一朗, 高松　悠樹, Yedidi Ravikiran, 長谷川和也, Arun K Ghosh and 満屋裕明
- Organizer
  白馬シンポジウムin山梨
- Place of Presentation
  山梨
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-16K15520
[Presentation] 前例を見ない程強力な活性を有する新規HIV-1プロテアーゼ阻害剤KU-241の同定2016
- Author(s)
  服部真一朗, 青木学, 鍬田伸好, 青木宏美, 林宏典, Arun K. Ghosh, 前田賢次, 満屋裕明
- Organizer
  第26回抗ウイルス療法学会総会
- Place of Presentation
  名古屋
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-26293239
[Presentation] KU-241が前例を見ない程強力な抗HIV活性を発揮する機序の解析2016
- Author(s)
  林宏典, 青木学, Debananda Das, 服部真一朗, 青木宏美, 鍬田伸好, 高松　悠樹, Yedidi Ravikiran, 長谷川和也, Arun K Ghosh and 満屋裕明
- Organizer
  第30回日本エイズ学会学術集会・総会
- Place of Presentation
  鹿児島
- Year and Date
  2016-11-24
- Data Source
  KAKENHI-PROJECT-16K15520
[Presentation] 表面プラズモン共鳴法を用いた新規HIV-1侵入阻害剤活性評価法の樹立2016
- Author(s)
  松田幸樹, 林宏典, 原田恵嘉, 服部真一朗, 鳴海哲夫, 玉村啓和, 吉村和久, 満屋裕明, 前田賢次
- Organizer
  第30回日本エイズ学会学術集会・総会
- Place of Presentation
  鹿児島
- Year and Date
  2016-11-24
- Data Source
  KAKENHI-PROJECT-26293239
[Presentation] KU-241が前例を見ない程強力な抗HIV作用を発揮するメカニズムの解析2016
- Author(s)
  林宏典, 青木学, Debananda Das, 服部真一朗, 高松　悠樹, Yedidi Ravikiran, 長谷川和也, Arun K Ghosh, 満屋裕明
- Organizer
  第26回抗ウイルス療法学会総会
- Place of Presentation
  名古屋
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-16K15520
[Presentation] DRV耐性株を含む種々の多剤耐性変異株にも有効な新規抗HIV薬候補化合物KU-241の体内動態・脳組織内濃度・2週間反復投与毒性2016
- Author(s)
  鍬田伸好, 青木学, 服部真一朗, 青木宏美, 林宏典, 前田賢次, Arun K. Ghosh, 満屋裕明
- Organizer
  第30回日本エイズ学会学術集会・総会
- Place of Presentation
  鹿児島
- Year and Date
  2016-11-24
- Data Source
  KAKENHI-PROJECT-26293239
[Presentation] HIV-1プロテアーゼのflap領域と相互作用する化合物はdarunavir高度耐性HIV-1を強力に阻害する2016
- Author(s)
  林宏典, 青木学, Yedidi Ravikiran, 中田浩智, Debananda Das, 中村照也, 長谷川和也, 山縣ゆり子, Arun K Ghosh, 満屋裕明
- Organizer
  第26回抗ウイルス療法学会総会
- Place of Presentation
  名古屋
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-26293239
[Presentation] 前例を見ない程強力な活性を有する新規HIV-1プロテアーゼ阻害剤KU-241の同定2016
- Author(s)
  服部真一朗, 青木学, 鍬田伸好, 青木宏美, 林宏典, Arun K. Ghosh, 前田賢次, 満屋裕明
- Organizer
  第26回抗ウイルス療法学会総会
- Place of Presentation
  名古屋
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-16K15520
[Presentation] KU-241が前例を見ない程強力な抗HIV活性を発揮する機序の解析2016
- Author(s)
  林宏典, 青木学, Debananda Das, 服部真一朗, 青木宏美, 鍬田伸好, 高松　悠樹, Yedidi Ravikiran, 長谷川和也, Arun K Ghosh and 満屋裕明
- Organizer
  第30回日本エイズ学会学術集会・総会
- Place of Presentation
  鹿児島
- Year and Date
  2016-11-24
- Data Source
  KAKENHI-PROJECT-26293239
[Presentation] 前例を見ない程強力な抗HIV活性を有する新規HIV-1プロテアーゼ阻害剤、KU-2412016
- Author(s)
  服部真一朗, 青木学, 鍬田伸好, 林宏典, 青木宏美, Arun K. Ghosh, 満屋裕明
- Organizer
  白馬シンポジウムin山梨
- Place of Presentation
  山梨
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-16K15520
[Presentation] In vitro evaluation of the genotoxic　potential of the novel anti-HIV protease　inhibitor, KU-241, which is potent against multi-PI-Resistant HIV-1 variants2015
- Author(s)
  Nobuyo Higashi-Kuwata、Manabu Aoki1、Shinichiro Hattori、Hiromi Ogata-Aoki、Hironori Hayashi、Kenji Maeda、Arun K. Ghosh、Hiroaki Mitsuya
- Organizer
  第29回日本エイズ学会学術集会・総会
- Place of Presentation
  東京ドームホテル（東京都）
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-26293239
[Presentation] Modified P1-Moiety Enhances Antiviral Activity against Drug-Resistant HIV-1 Variants and Central Nervous System (CNS) Penetration Effectiveness of Newly-Generated HIV-1 Protease Inhibitors In Vitro.2015
- Author(s)
  Masayuki Amano and Hiroaki Mitsuya
- Organizer
  第16回熊本エイズセミナー
- Place of Presentation
  阿蘇ホテルグランビリオ（熊本県阿蘇市）
- Year and Date
  2015-10-07
- Data Source
  KAKENHI-PROJECT-15K15382
[Presentation] Modified P1-Moiety Enhances Antiviral Activity against Drug-Resistant HIV-1 Variants and Central Nervous System (CNS) Penetration Effectiveness of Newly-Generated HIV-1 Protease Inhibitors In Vitro.2015
- Author(s)
  Masayuki Amano and Hiroaki Mitsuya
- Organizer
  第16回熊本エイズセミナー
- Place of Presentation
  阿蘇ホテルグランビリオ（熊本県阿蘇市）
- Year and Date
  2015-10-07
- Data Source
  KAKENHI-PROJECT-26293239
[Presentation] n vitro evaluation of the genotoxic　potential of the novel anti-HIV protease　inhibitor, KU-241, which is potent against multi-PI-Resistant HIV-1 variants2015
- Author(s)
  Nobuyo Higashi-Kuwata、Manabu Aoki1、Shinichiro Hattori、Hiromi Ogata-Aoki、Hironori Hayashi、Kenji Maeda、Arun K. Ghosh、Hiroaki Mitsuya
- Organizer
  第29回日本エイズ学会学術集会・総会
- Place of Presentation
  東京ドームホテル（東京都）
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-15K15382
[Presentation] 新規HIV-1 プロテアーゼ阻害剤KU-241 の同定と抗HIV 活性の検討2015
- Author(s)
  服部真一朗、青木学、鍬田伸好、青木宏美、林宏典、Arun K. Ghosh、前田賢次、満屋裕明
- Organizer
  第29回日本エイズ学会学術集会・総会
- Place of Presentation
  東京ドームホテル（東京都）
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-15K15382
[Presentation] 新規HIV-1プロテアーゼ阻害剤開発と構造解析2015
- Author(s)
  林宏典、青木学、Yedidi Ravikiran、中田浩智、Debananda Das、中村照也、長谷川和也、山縣ゆり子、Arun K Ghosh、満屋裕明
- Organizer
  第17回白馬シンポジウム in 米子
- Place of Presentation
  鳥取大学医学部（鳥取県米子市）
- Year and Date
  2015-06-19
- Data Source
  KAKENHI-PROJECT-26293239
[Presentation] 新規HIV-1プロテアーゼ阻害剤開発と構造解析2015
- Author(s)
  林宏典、青木学、Yedidi Ravikiran、中田浩智、Debananda Das、中村照也、長谷川和也、山縣ゆり子、Arun K Ghosh、満屋裕明
- Organizer
  第17回白馬シンポジウム
- Place of Presentation
  鳥取大学医学部（鳥取県米子市）
- Year and Date
  2015-06-19
- Data Source
  KAKENHI-PROJECT-15K15382
[Presentation] Novel protease inhibitors, which bind to the flap region of HIV-1 protease, strongly inhibit multi-drug resistant HIV-1 variants including darunavir- resistant variants.2015
- Author(s)
  Hironori Hayashi, Manabu Aoki, Ravikiran S. Yedidi, Hirotomo Nakata, Debananda Das, Teruya Nakamura, Kazuya Hasegawa, Yuriko Yamagata, Arun K. Ghosh and Hiroaki Mitsuya
- Organizer
  第16回熊本エイズセミナー
- Place of Presentation
  阿蘇ホテルグランビリオ（熊本県阿蘇市）
- Year and Date
  2015-10-07
- Data Source
  KAKENHI-PROJECT-15K15382
[Presentation] Novel protease inhibitors, which　bind to protease’s flap region,　strongly inhibit multi-drug resistant HIV-1 variants including darunavir-resistant variants2015
- Author(s)
  Hironori Hayashi、Manabu Aoki、Ravikiran S. Yedidi、Hirotomo Nakata、Debananda Das、Teruya NakamuraKazuya Hasegawa、Yuriko Yamagata、Arun K. Ghosh、Hiroaki Mitsuya
- Organizer
  第29回日本エイズ学会学術集会・総会
- Place of Presentation
  東京ドームホテル（東京都）
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-26293239
[Presentation] 新規HIV-1 プロテアーゼ阻害剤KU-241 の同定と抗HIV 活性の検討2015
- Author(s)
  服部真一朗、青木学、鍬田伸好、青木宏美、林宏典、Arun K. Ghosh、前田賢次、満屋裕明
- Organizer
  第29回日本エイズ学会学術集会・総会
- Place of Presentation
  東京ドームホテル（東京都）
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-26293239
[Presentation] Novel protease inhibitors, which　bind to protease’s flap region,　strongly inhibit multi-drug resistant HIV-1 variants including darunavir-resistant variants2015
- Author(s)
  Hironori Hayashi、Manabu Aoki、Ravikiran S. Yedidi、Hirotomo Nakata、Debananda Das、Teruya NakamuraKazuya Hasegawa、Yuriko Yamagata、Arun K. Ghosh、Hiroaki Mitsuya
- Organizer
  第29回日本エイズ学会学術集会・総会
- Place of Presentation
  東京ドームホテル（東京都）
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-15K15382
[Presentation] Novel protease inhibitors, which bind to the flap region of HIV-1 protease, strongly inhibit multi-drug resistant HIV-1 variants including darunavir- resistant variants.2015
- Author(s)
  Hironori Hayashi, Manabu Aoki, Ravikiran S. Yedidi, Hirotomo Nakata, Debananda Das, Teruya Nakamura, Kazuya Hasegawa, Yuriko Yamagata, Arun K. Ghosh and Hiroaki Mitsuya
- Organizer
  第16回熊本エイズセミナー
- Place of Presentation
  阿蘇ホテルグランビリオ（熊本県阿蘇市）
- Year and Date
  2015-10-07
- Data Source
  KAKENHI-PROJECT-26293239
[Presentation] ② Screenig HIV-1 Integrasde LEDGF binding inhibitors using BiFC2013
- Author(s)
  Joseph R. Campbell, Tomofumi Nakamura, Haruo Aikawa, Hirokazu Tamamura, and Hiroaki Mitsuya
- Organizer
  第15回白馬シンポジウム
- Place of Presentation
  名古屋医療センター（名古屋市中区）
- Data Source
  KAKENHI-PROJECT-25670467
[Presentation] HIV暴露後早期における抗HIV剤投与効果の解析2013
- Author(s)
  青木宏美、満屋裕明
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本市民会館（熊本市中央区）
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] HIVのDRV耐性獲得機構の解明2013
- Author(s)
  林宏典, 満屋裕明
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本市民会館, 熊本市
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] HIV患者における可溶性IL-24受容体増加の意義2013
- Author(s)
  宮川寿一, 満屋裕明
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本市民会館, 熊本市
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] New HIV-1 protease inhibitors with potent antiviral activity and potentially favorable CNS penetration2013
- Author(s)
  Pedro Miguel Salcedo Gomez , 満屋裕明
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本市民会館, 熊本市
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] HIV-1インテグラーゼ多量体形成を制御する薬剤のBiFC法による評価2013
- Author(s)
  中村朋文、Joseph R. Campbell、Amber R. Moore 相川春夫、玉村啓和、満屋裕明
- Organizer
  第15回白馬シンポジウム
- Place of Presentation
  名古屋医療センター（名古屋市中区）
- Data Source
  KAKENHI-PROJECT-25670467
[Presentation] Studing HIV-1 integrase LEDGF binding inhibitors using bimolecular fluorescence complementation.2013
- Author(s)
  Joseph R. Campbell, 満屋裕明
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本市民会館, 熊本市
- Data Source
  KAKENHI-PROJECT-25670467
[Presentation] HIV-1 インテグラーゼ多量体形成を制御する薬剤のBiFC法による評価2013
- Author(s)
  中村朋文、満屋裕明
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本市民会館（熊本市中央区）
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] ① Screening HIV-1 Integrasde LEDGF binding inhibitors using BiFC2013
- Author(s)
  Joseph R. Campbell, Tomofumi Nakamura, Haruo Aikawa, Hirokazu Tamamura, and Hiroaki Mitsuya
- Organizer
  第23回抗ウイルス療法研究会総会
- Place of Presentation
  リーガロイヤルホテル東京（東京都新宿区）
- Data Source
  KAKENHI-PROJECT-25670467
[Presentation] Studing HIV-1 integrase LEDGF binding inhibitors using bimolecular fluorescence complementation2013
- Author(s)
  Joseph R. Campbell, 満屋裕明
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本市民会館, 熊本市
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] Studying HIV-1 Integrasde LEDGF binding inhibitors using BiFC2013
- Author(s)
  Joseph R. Campbell, Tomofumi Nakamura, Haruo Aikawa, Hirokazu Tamamura, Hiroaki Mitsuya
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本市民会館（熊本市中央区）
- Data Source
  KAKENHI-PROJECT-25670467
[Presentation] HIV-1 Capsid 蛋白 (CA) の挿入変異がもたらす CA 自己崩壊の分子機構の解明およびCA 阻害活性を有する低分子化合物の検索・同定2013
- Author(s)
  天野将之、満屋裕明
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本市民会館（熊本市中央区）
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] HIV-1インテグラーゼ多量体形成を制御する薬剤の BiFC法による評価2013
- Author(s)
  中村朋文, 中田浩智, 満屋裕明
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本市民会館, 熊本市
- Data Source
  KAKENHI-PROJECT-25670467
[Presentation] Dymanics of IN multierzation and a potent modulation by allosteric HIV-1 intgrase inhibiters in living cells using BiFC2013
- Author(s)
  中村朋文, 満屋裕明
- Organizer
  14th Kumamoto AIDS Seminar
- Place of Presentation
  Kumamoto Hotel Casstle, Aso Resort Grandvrio
- Data Source
  KAKENHI-PROJECT-25670467
[Presentation] 非MACの非定型抗酸菌感染による免疫再構築症候群(IRIS)で治療に難渋した2症例2013
- Author(s)
  中田浩智, 満屋裕明
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本市民会館, 熊本市
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] 新規プロテアーゼ阻害剤 GRL-015, 085, 097 は , プロテアーゼD29, D30, G48の主鎖と重要な水素結合を形成, 多剤耐性HIV-1変異体に強力な活性を発揮する2013
- Author(s)
  青木学, 満屋裕明
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本市民会館, 熊本市
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] HIV感染患者における可溶性IL-2受容体増加の意義2013
- Author(s)
  宮川寿一、満屋裕明
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本市民会館（熊本市中央区）
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] Evaluation of HIV-1 reverse transcriptase (RT) heterodimerization within living cells using bimolecular fl uorescence complementation (BiFC)2013
- Author(s)
  Amber R. Moore、満屋裕明
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本市民会館（熊本市中央区）
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] Accessing HIV-1 Integrasde LEDGF binding inhibitors using BiFC2013
- Author(s)
  Joseph R. Campbell, Tomofumi Nakamura, Haruo Aikawa, Hirokazu Tamamura, Hiroaki Mitsuya
- Organizer
  第14回熊本エイズセミナー
- Place of Presentation
  熊本ホテルキャッスル（熊本市中央区）、阿蘇グランヴィリオホテル（阿蘇市）
- Data Source
  KAKENHI-PROJECT-25670467
[Presentation] HIVのDRV 耐性獲得機構の解明2013
- Author(s)
  林宏典、満屋裕明
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本市民会館（熊本市中央区）
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] HIV-1インテグラーゼ多量体形成を制御する薬剤の BiFC法による評価2013
- Author(s)
  中村朋文, 満屋裕明
- Organizer
  第15回白馬シンポジウム
- Place of Presentation
  国立病院機構名古屋医療センター
- Data Source
  KAKENHI-PROJECT-25670467
[Presentation] HIV-1インテグラーゼ多量体形成を制御する薬剤のBiFC法による評価2013
- Author(s)
  中村朋文、Joseph R. Campbell、Amber R. Moore 相川春夫、玉村啓和、満屋裕明
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本市民会館（熊本市中央区）
- Data Source
  KAKENHI-PROJECT-25670467
[Presentation] HIV暴露後早期における抗HIV剤投与効果の解析2013
- Author(s)
  青木宏美, 満屋裕明
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本市民会館, 熊本市
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] HIV-I Capsid蛋白(CA)の挿入変異がもたらすCA個崩壊の分子機構の解明およびCA阻害活性を有する低分子化合物の検索・同定2013
- Author(s)
  天野将之, 満屋裕明
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本市民会館, 熊本市
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] ① Dymanics of IN multierzation and a potent modulation by allosteric HIV-1 intgrase inhibiters in living cells using BiFC2013
- Author(s)
  Tomofumi Nakamura, Joseph R. Campbell, Amber R. Moore, Haruo Aikawa, Hirokazu Tamamura, and Hiroaki Mitsuya
- Organizer
  第14回熊本エイズセミナー
- Place of Presentation
  熊本ホテルキャッスル（熊本市中央区）、阿蘇グランヴィリオホテル（阿蘇市）
- Data Source
  KAKENHI-PROJECT-25670467
[Presentation] 非MAC の非定型抗酸菌感染による免疫再構築症候群(IRIS)で治療に難渋した2 症例2013
- Author(s)
  中田浩智、満屋裕明
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本市民会館（熊本市中央区）
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] 新規プロテアーゼ阻害剤GRL-015, -085,-097は、プロテアーゼD29, D30, G48の主鎖と重要な水素結合を形成、多剤耐性HIV-1 変異体に強力な活性を発揮する2013
- Author(s)
  青木学、満屋裕明
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本市民会館（熊本市中央区）
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] New HIV-1 protease inhibitors with potent antiviral activity and potentially favorable CNS penetration2013
- Author(s)
  Pedro Miguel Salcedo Gomez1、満屋裕明
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本市民会館（熊本市中央区）
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] Studying HIV-1 Integrase LEDGF binding inhibitors using bimolecular fluorescence complementation2013
- Author(s)
  Joseph R.Campbell、満屋裕明
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本市民会館（熊本市中央区）
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] Evaluation of HIV-1 reverse transcriptase(RT) heterodimerization within living cells using bimolecular fluorescence complemention (BiFC).2013
- Author(s)
  Amber R. Moore, 満屋裕明
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本市民会館, 熊本市
- Data Source
  KAKENHI-PROJECT-25670467
[Presentation] Evaluation of HIV-1 reverse transcriptase (RT) heterodimerization within living cells using bimolecular fluorescence complemention (BiFC)2013
- Author(s)
  Amber R. Moore, 満屋裕明
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本市民会館, 熊本市
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] HIV-1 capsid蛋白 (CA) の挿入変異がもたらすCA自壊の分子機構の解明およびCA阻害活性を有する化合物の検索2012
- Author(s)
  天野将之, 満屋裕明
- Organizer
  第26回日本エイズ学会学術集会
- Place of Presentation
  慶應義塾大学日吉キャンパス, 横浜市
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] HIV プロテアーゼ二量体化機構及び DRV の二量体化阻害メカニズムの解明2012
- Author(s)
  林宏典, 高宗暢暁, 三隅将吾, 青木学, 満屋裕明
- Organizer
  第14回白馬シンポジウム
- Place of Presentation
  京都市国際交流会館(京都)
- Data Source
  KAKENHI-PROJECT-24659484
[Presentation] DRV耐性HIV- 1変異株にも強力な活性を発揮する新規プロテアーゼ阻害剤GRL- 015- 11A, GRL- 085- 11A, GRL-097- 11Aの抗HIV- 1活性の検討2012
- Author(s)
  青木学, 満屋裕明
- Organizer
  第26回日本エイズ学会学術集会
- Place of Presentation
  慶應義塾大学日吉キャンパス, 横浜市
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] HIV-1 capsid蛋白（CA）の挿入変異がもたらすCA自壊の分子機構の解明およびCA阻害活性を有する化合物の検索2012
- Author(s)
  天野将之、満屋裕明
- Organizer
  第26回日本エイズ学会学術集会
- Place of Presentation
  横浜市（慶應義塾大学日吉キャンパス）
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] HIV プロテアーゼ二量体化機構及び darunavir の二量体化阻害メカニズムの解明2012
- Author(s)
  林宏典, 高宗暢暁, 三隅将吾, 青木学, 満屋裕明
- Organizer
  第26回エイズ学会学術集会・総会
- Place of Presentation
  慶應義塾大学日吉キャンパス(神奈川)
- Data Source
  KAKENHI-PROJECT-24659484
[Presentation] NRTI- sparingcARTが著効した拡張型心筋症合併AIDS症例2012
- Author(s)
  宮川寿一, 満屋裕明
- Organizer
  第26回日本エイズ学会学術集会
- Place of Presentation
  慶應義塾大学日吉キャンパス, 横浜市
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] BiFC法によるHIV-1インテグラーゼの多量体評価及び薬剤阻害効果の検討2012
- Author(s)
  中村朋文、満屋裕明
- Organizer
  第26回日本エイズ学会学術集会
- Place of Presentation
  横浜市（慶應義塾大学日吉キャンパス）
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] The binding properties of darunavir to HIV-1 protease monomer subunit.2012
- Author(s)
  Hironori Hayashi, Nobutoki Takamune, Manabu Aoki, Yasuhiro Koh, Shogo Misumi & (Hiroaki Mitsuya)
- Organizer
  第13回熊本エイズセミナー・グローバルCOE合同シンポジウム
- Place of Presentation
  ホテル日航熊本、阿蘇グランヴィリオホテル
- Data Source
  KAKENHI-PROJECT-24659484
[Presentation] Thebinding properties of darunavir toHIV-1 protease monomer subunit2012
- Author(s)
  Hironori Hayashi, Nobutoki Takamune,Manabu Aoki, Yasuhiro Koh, ShogoMisumi and Hiroaki Mitsuya
- Organizer
  第13回熊本エイズセミナー・グローバルCOE 合同シンポジウム
- Place of Presentation
  ホテル日航熊本(熊本)
- Data Source
  KAKENHI-PROJECT-24659484
[Presentation] BiFC法によるHIV-1インテグラーゼの多量体評価及び薬剤阻害効果の検討2012
- Author(s)
  中村朋文, 満屋裕明
- Organizer
  第26回日本エイズ学会学術集会
- Place of Presentation
  慶應義塾大学日吉キャンパス, 横浜市
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] HIVプロテアーゼ二量体化機構及びDRVの二量体化阻害メカニズムの解明2012
- Author(s)
  林宏典, 高宗暢暁, 三隅将吾, 青木学, (満屋裕明)
- Organizer
  第14回白馬シンポジウム
- Place of Presentation
  京都市国際交流会館
- Data Source
  KAKENHI-PROJECT-24659484
[Presentation] HIVプロテアーゼ二量体化及びdarunavirの二量体化阻害メカニズムの解明2012
- Author(s)
  林宏典、満屋裕明
- Organizer
  第26回日本エイズ学会学術集会
- Place of Presentation
  横浜市（慶應義塾大学日吉キャンパス）
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] GRL-01511A: a Novel HIV-1 Protease Inhibitor Potent Against Multi-PI-Resistant HIV-1s.2012
- Author(s)
  青木学、満屋裕明
- Organizer
  25th International Conference on Antiviral Research (ICAR)
- Place of Presentation
  札幌市（ロイトン札幌）
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] GRL- 007 : a Novel Small Molecule CCR5 Antagonist Potent Against a Wide Spectrumof HIV- 12012
- Author(s)
  中田浩智, 満屋裕明
- Organizer
  25th International Conference on Antiviral Research (ICAR)
- Place of Presentation
  ロイトン札幌, 札幌市
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] GRL- 01511A : a Novel HIV- 1 Protease Inhibitor Potent Against Multi- PI- Resistant HIV- 1s2012
- Author(s)
  青木学, 満屋裕明
- Organizer
  25th International Conference on Antiviral Research (ICAR)
- Place of Presentation
  ロイトン札幌, 札幌市
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] DRV耐性HIV-1変異株にも強力な活性を発揮する新規プロテアーゼ阻害剤GRL-015-11A, GRL-085-11A, GRL-097-11Aの抗HIV-1活性の検討2012
- Author(s)
  青木学、満屋裕明
- Organizer
  第26回日本エイズ学会学術集会
- Place of Presentation
  横浜市（慶應義塾大学日吉キャンパス）
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] HIVプロテアーゼ二量体化機構及びdarunavirの二量体化阻害メカニズムの解明2012
- Author(s)
  林宏典, 高宗暢暁, 三隅将吾, 青木学, 満屋裕明
- Organizer
  第26回　エイズ学会学術集会・総会
- Place of Presentation
  慶應義塾大学　日吉キャンパス
- Data Source
  KAKENHI-PROJECT-24659484
[Presentation] Structure‐Guided Development of AIDS Therapeutics: Successes, Challenges, and Opportunities2012
- Author(s)
  満屋裕明
- Organizer
  25th International Conference on Antiviral Research (ICAR)
- Place of Presentation
  札幌市（ロイトン札幌）
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] GRL-007: a Novel Small Molecule CCR5 Antagonist Potent Against a Wide Spectrum of HIV-1.2012
- Author(s)
  中田浩智、満屋裕明
- Organizer
  25th International Conference on Antiviral Research (ICAR)
- Place of Presentation
  札幌市（ロイトン札幌）
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] A Novel Oxatricyclic-Ligand-Containing Nonpeptidic Protease Inhibitor (PI) GRL-0519A Potent Against Multi-PI-Resistant HIV In Vitro.2012
- Author(s)
  天野将之、満屋裕明
- Organizer
  25th International Conference on Antiviral Research (ICAR)
- Place of Presentation
  札幌市（ロイトン札幌）
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] HIVプロテアーゼ二量体化及びdarunavirの二量体化阻害メカニズムの解明2012
- Author(s)
  林宏典, 満屋裕明
- Organizer
  第26回日本エイズ学会学術集会
- Place of Presentation
  慶應義塾大学日吉キャンパス, 横浜市
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] NRTI-sparing-cARTが著効した拡張型心筋症合併AIDS症例2012
- Author(s)
  宮川寿一、満屋裕明
- Organizer
  第26回日本エイズ学会学術集会
- Place of Presentation
  横浜市（慶應義塾大学日吉キャンパス）
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] 抗HIV剤raltegravirによるHIV体内播種早期ダイナミクスの変容2012
- Author(s)
  鍬田伸好、満屋裕明
- Organizer
  第26回日本エイズ学会学術集会
- Place of Presentation
  横浜市（慶應義塾大学日吉キャンパス）
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] Binding properties of darunavir to the HIV-1 protease monomer subunit.2012
- Author(s)
  Hironori Hayashi, Nobutoki Takamune, Manabu Aoki, Yasuhiro Koh, Shogo Misumi & (Hiroaki Mitsuya)
- Organizer
  第13回熊本エイズセミナー・グローバルCOE合同シンポジウム
- Place of Presentation
  ホテル日航熊本、阿蘇グランヴィリオホテル
- Data Source
  KAKENHI-PROJECT-24659484
[Presentation] BiFC法 (蛋白再構成法) によるHIV -1 インテグラーゼの4量体形成の可視化及び定量化2011
- Author(s)
  中村朋文, 満屋裕明
- Organizer
  第25回日本エイズ学会学術集会
- Place of Presentation
  ハイアットリージェンシー東京, 東京都新宿区
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] 蛍光蛋白質ラベル化HIVの分子基盤解析2011
- Author(s)
  林宏典、満屋裕明
- Organizer
  第25回日本エイズ学会学術集会
- Place of Presentation
  ハイアットリージェンシー東京
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] mCherry可視化HIV -1を用いたHIV -1体内播種早期ダイナミクスの検討 : 抗HIV薬を用いた治療による変化2011
- Author(s)
  青木宏美, 満屋裕明
- Organizer
  第21回抗ウイルス療法研究会
- Place of Presentation
  金沢市文化ホール, 金沢市
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] mCherry可視化HIV-1を用いたHIV-1体内播種早期ダイナミクスと抗HIV剤によるその変容の形態学的検討2011
- Author(s)
  鍬田伸好、青木宏美、服部真一郎、林宏典、青木学、岡田誠治、満屋裕明
- Organizer
  第13回白馬シンポジウム
- Place of Presentation
  北海道大学医学部学友会館(札幌)
- Data Source
  KAKENHI-PROJECT-23659509
[Presentation] mCherry 可視化HIV を用いた HIV 体内播種早期ダイナミクスと抗 HIV 剤によるその変容の検討-22011
- Author(s)
  鍬田伸好, 満屋裕明
- Organizer
  第25回日本エイズ学会学術集会
- Place of Presentation
  ハイアットリージェンシー東京, 東京都新宿区
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] 蛍光蛋白質タグ可視化HIV発現の分子基盤の解明2011
- Author(s)
  林宏典、青木宏美、鍬田伸好、満屋裕明
- Organizer
  第13回白馬シンポジウム
- Place of Presentation
  北海道大学医学部学友会館(札幌)
- Data Source
  KAKENHI-PROJECT-23659509
[Presentation] mCherry可視化HIV-1を用いたHIV-1体内播種早期ダイナミクスと抗HIV剤によるその変容の検討-12011
- Author(s)
  青木宏美、鍬田伸好、服部真一郎、林宏典、青木学、岡田誠治、満屋裕明
- Organizer
  第25回日本エイズ学会学術集会・総会
- Place of Presentation
  ハイアットリージェンシー東京(東京)
- Data Source
  KAKENHI-PROJECT-23659509
[Presentation] Oxatricyclic (tris-tetrahydrofuranylurethane : tris-THF)構造を有する新規のHIVプロテアーゼ阻害剤(PI),GRL-0519の抗ウイルス活性の検討2011
- Author(s)
  天野将之、満屋裕明
- Organizer
  第21回抗ウイルス療法研究会
- Place of Presentation
  金沢市文化ホール(石川)
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] mCherry可視化HIV-1を用いたHIV-1体内播種早期ダイナミクスの検討:抗HIV薬を用いた治療による変化2011
- Author(s)
  青木宏美、鍬田伸好、服部真一郎、林宏典、青木学、岡田誠治、満屋裕明
- Organizer
  第21回抗ウイルス療法研究会
- Place of Presentation
  金沢市文化ホール(金沢)
- Data Source
  KAKENHI-PROJECT-23659509
[Presentation] 蛍光蛋白質ラベル化HIVの分子基盤解析2011
- Author(s)
  林宏典、青木宏美、鍬田伸好、満屋裕明
- Organizer
  第25回日本エイズ学会学術集会・総会
- Place of Presentation
  ハイアットリージェンシー東京(東京)
- Data Source
  KAKENHI-PROJECT-23659509
[Presentation] Emergence of HIV-1 Variants Highly Resistant to Darunavir and the Resistance Mechanism2011
- Author(s)
  Matthew L.Danish、満屋裕明
- Organizer
  第21回抗ウイルス療法研究会
- Place of Presentation
  金沢市文化ホール(石川)
- Year and Date
  2011-05-30
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] HIV-1 capsid蛋白(CA)の挿入変異がもたらすCA自壊の分子機構の解明2011
- Author(s)
  天野将之、満屋裕明
- Organizer
  第25回日本エイズ学会学術集会
- Place of Presentation
  ハイアットリージェンシー東京
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] BiFC法(蛋白再構成法)によるHIV-1インテグラーゼの4量体形成の可視化及び定量化2011
- Author(s)
  中村朋文、満屋裕明
- Organizer
  第25回日本エイズ学会学術集会
- Place of Presentation
  ハイアットリージェンシー東京
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] mCherry可視化HIV-1を用いたHIV-1体内播種早期ダイナミクスと抗HIV剤によるその変容の検討2011
- Author(s)
  青木宏美、鍬田伸好、服部真一郎、林宏典、青木学、岡田誠治、満屋裕明
- Organizer
  第81回日本感染症学会西日本地方会学術集会
- Place of Presentation
  北九州国際会議場/ホテルニュータガワ(北九州)
- Data Source
  KAKENHI-PROJECT-23659509
[Presentation] mCherry可視化HIV-1を用いたHIV-1体内播種早期ダイナミクスと抗HIV剤によるその変容の検討2011
- Author(s)
  青木宏美、鍬田伸好、服部真一郎、林宏典、青木学、岡田誠治、満屋裕明
- Organizer
  第13回白馬シンポジウム
- Place of Presentation
  北海道大学医学部学友会館(札幌)
- Data Source
  KAKENHI-PROJECT-23659509
[Presentation] Alterration of the dynamics of HIVmC dissemination in huPBMC NOJ mice under Raltegravir administration2011
- Author(s)
  Nobuyo Higashi-Kuwata, Hiromi Ogata-Aoki, Tahei Nakamura, Shinichiro Hattori, Hironori Hayashi, Manabu Aoki, Seiji Okada, Hiroaki Mitsuya
- Organizer
  12^<th> KUMAMOTO AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Hotel Nikko Kumamoto and Aso Resort Grandvrio Hotel(Kumamoto)
- Data Source
  KAKENHI-PROJECT-23659509
[Presentation] mCherry可視化HIVを用いたHIV体内播種早期ダイナミクスと抗HIV剤によるその変容の検討-22011
- Author(s)
  鍬田伸好、満屋裕明
- Organizer
  第25回日本エイズ学会学術集会
- Place of Presentation
  ハイアットリージェンシー東京
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] Tipranavirの酵素活性阻止能とプロテアーゼ二量体化阻止能の喪失に関与するアミノ酸変異の同定2011
- Author(s)
  青木学, 満屋裕明
- Organizer
  第21回抗ウイルス療法研究会
- Place of Presentation
  金沢市文化ホール, 金沢市
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] Tipranavirの酵素活性阻止能とプロテアーゼ二量体化阻止能の喪失に関与するアミノ酸変異の同定2011
- Author(s)
  青木学, 満屋裕明
- Organizer
  第25回日本エイズ学会学術集会
- Place of Presentation
  ハイアットリージェンシー東京, 東京都新宿区
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] mCherry可視化HIVを用いたHIV体内播種早期ダイナミクスと抗HIV剤によるその変容の検討-12011
- Author(s)
  青木宏美、満屋裕明
- Organizer
  第25回日本エイズ学会学術集会
- Place of Presentation
  ハイアットリージェンシー東京
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] Early Phase Dynamics of HIV Infection in hPBMC-Transplanted NOD/SCID/Jak3-/-Mice Using Infectious HIV Carrying a Fluorescent Protein, mCherry2011
- Author(s)
  Hiromi Ogata-Aoki, Nobuyo Higashi-Kuwata, Shinichiro Hattori, Hironori Hayashi, Manabu Aoki, Kenji Maeda, Seiji Okada, Hiroaki Mitsuya
- Organizer
  12^<th> KUMAMOTO AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Hotel Nikko Kumamoto and Aso Resort Grandvrio Hotel(Kumamoto)
- Data Source
  KAKENHI-PROJECT-23659509
[Presentation] mCherry可視化HIV-1を用いたHIV-1体内播種早期ダイナミクスと抗HIV剤によるその変容の検討-22011
- Author(s)
  鍬田伸好、青木宏美、服部真一郎、林宏典、青木学、岡田誠治、満屋裕明
- Organizer
  第25回日本エイズ学会学術集会・総会
- Place of Presentation
  ハイアットリージェンシー東京(東京)
- Data Source
  KAKENHI-PROJECT-23659509
[Presentation] HIV-1capsid蛋白(CA) の挿入変異がもたらすCA自壊の分子機構の解明2011
- Author(s)
  天野将之, 満屋裕明
- Organizer
  第25回日本エイズ学会学術集会
- Place of Presentation
  ハイアットリージェンシー東京, 東京都新宿区
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] Tipranavirの酵素活性阻止能とプロテアーゼ二量体化阻止能の喪失に関与するアミノ酸変異の同定2011
- Author(s)
  青木学、満屋裕明
- Organizer
  第21回抗ウイルス療法研究会
- Place of Presentation
  金沢市文化ホール(石川)
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] 蛍光蛋白質ラベル化HIVの分子基盤解析2011
- Author(s)
  林宏典, 満屋裕明
- Organizer
  第25回日本エイズ学会学術集会
- Place of Presentation
  ハイアットリージェンシー東京, 東京都新宿区
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] mCherry 可視化HIV を用いた HIV 体内播種早期ダイナミクスと抗 HIV 剤によるその変容の検討-12011
- Author(s)
  青木宏美, 満屋裕明
- Organizer
  第25回日本エイズ学会学術集会
- Place of Presentation
  ハイアットリージェンシー東京, 東京都新宿区
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] mCherry可視化HIV-1を用いたHIV-1体内播種早期ダイナミクスの検討:抗HIV薬を用いた治療による変化2011
- Author(s)
  青木宏美、満屋裕明
- Organizer
  第21回抗ウイルス療法研究会
- Place of Presentation
  金沢市文化ホール(石川)
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] Tipranavirの酵素活性阻止能とプロテアーゼ二量体化阻止能の喪失に関与するアミノ酸変異の同定2011
- Author(s)
  青木学、満屋裕明
- Organizer
  第25回日本エイズ学会学術集会
- Place of Presentation
  ハイアットリージェンシー東京
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-23390265
[Presentation] HIV-1の体内播種とin vivo imaging-概要-2010
- Author(s)
  鍬田伸好、青木宏美、服部真一朗、中村太平、青木学、前田賢次、岡田誠治、満屋裕明
- Organizer
  第24回エイズ学会総会グランドプリンスホテル高輪・プリンスさくらタワー東京
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] The Binary Protease Inhibitor, Darunavir, Has a High Genetic Barrier to the Emergence of Resistant HIV-1 Variants2010
- Author(s)
  Yasuhiro Koh, M Aoki, M,Amano, H Ogata-Aoki, S Leschenko-Yashchuk, A Ghosh, H Mitsuya
- Organizer
  17th Conference on Retroviruses and Opportunistic Infections.No.p559.
- Place of Presentation
  Moscone Center West, San Francisco, CA, USA
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] 播種性ヒストプラズマ症と脳原発リンパ腫にて発症した1例2010
- Author(s)
  宮川寿一、徳永賢治、川口辰哉、満屋裕明
- Organizer
  第24回エイズ学会総会グランドプリンスホテル高輪・プリンスさくらタワー東京
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] Novel HIV-1 protease inhibitors (PIs) containing bis-tetrahydrofuran (bis- THF) and a novel polycyclic ligand2010
- Author(s)
  Kazuhiko Ide, Manabu Aoki, Yasuhiro Koh, Masayuki Amano, Sarang Kulkarni, David D. Anderson, Bruno Chapsal, Arun K. Ghosh, Hiroaki Mitsuya
- Organizer
  XVIII International AIDS conference
- Place of Presentation
  The Reed Messe Wien, Vienna,Austria, No. MOAA0102.
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] HIVプロテアーゼ阻害能(PI)とプロテアーゼ2量体形成阻害能(PDI)を有する新規化合物の同定と野生株・多剤耐性株に対する抗ウイルス活性の検討2010
- Author(s)
  井手一彦、青木学、天野将之、〓康博、Arun K.Ghosh、満屋裕明
- Organizer
  第24回エイズ学会総会グランドプリンスホテル高輪・プリンスさくらタワー東京
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] Tipranavir耐性HIVはプロテアーゼ二量体化阻止能と酵素活性阻止能の双方を喪失している2010
- Author(s)
  青木学、井手一彦、Matthew L.Danish、満屋裕明
- Organizer
  第24回エイズ学会総会グランドプリンスホテル高輪・プリンスさくらタワー東京
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] HIV-1 capsid蛋白(CA)の挿入変異とCA自壊の分子機構の解明2010
- Author(s)
  天野将之、田宮貞宏、〓康博、Matthew Danish、満屋裕明
- Organizer
  第24回エイズ学会総会グランドプリンスホテル高輪・プリンスさくらタワー東京
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] Mechanism of the Emergence of HIV-1 Variants Highly Resistant to Darunavir.2010
- Author(s)
  Matthew L.Danish, Manabu Aoki, Robert Shafer, Hiroaki Mitsuya
- Organizer
  第24回エイズ学会総会グランドプリンスホテル高輪・プリンスさくらタワー東京
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] HIV-1の体内播種とin vivo imaging-詳細-2010
- Author(s)
  青木宏美、鍬田伸好、服部真一朗、中村太平、青木学、前田賢次、岡田誠治、満屋裕明
- Organizer
  第24回エイズ学会総会グランドプリンスホテル高輪・プリンスさくらタワー東京
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] Macrocyclic Component-containing Protease Inhibitors(PIs)Active Against Multi-PI-Resistant HIV-1 In Vitro2009
- Author(s)
  Tojo Y, Mitsuya, H., et al.
- Organizer
  49^<th> Annual Interscience Conference on Antimicrobial Agents and Chemotherapy(ICAAC)
- Place of Presentation
  San Francisco, CA, US(米国)
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] Degradation of Gag Proteins in Multi -drug-resistant HIV Variants Containing Insertions in Gag Proteins2009
- Author(s)
  Amano M, Mitsuya, H., et al.
- Organizer
  49^<th> Annual Interscience Conference on Antimicrobial Agents and Chemotherapy(ICAAC)
- Place of Presentation
  San Francisco, CA, US(米国)
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] HIVプロテアーゼ阻害(PI)とプロテアーゼ2量体形成阻害(PDI)の2活性を有する新規化合物の同定と抗HIV活性の検討2009
- Author(s)
  井手一彦、〓康博、天野将之、Arun K.Ghosh、満屋裕明
- Organizer
  第23回エイズ学会総会
- Place of Presentation
  名古屋国際会議場、名古屋
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] Macrocyclic構造を有する新規プロテアーゼ阻害剤の抗HIV-1活性の検討2009
- Author(s)
  東條靖、〓康博、天野将之、Arun K, Ghosh、満屋裕明
- Organizer
  第23回エイズ学会総会
- Place of Presentation
  名古屋国際会議場、名古屋
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] 感染細胞内でHIVコンポーネントの自壊をもたらす機序の解明2009
- Author(s)
  天野将之、〓康博、田宮貞弘、満屋裕明
- Organizer
  第23回エイズ学会総会
- Place of Presentation
  名古屋国際会議場、名古屋
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] The binary mechanism of HIV-1 resistance to tipranavir(TPV) : Loss of inhibition of protease catalytic activity and protease dimerization2009
- Author(s)
  Aokl M, Mitsuya, H., et al.
- Organizer
  49^<th> Annual Interscience Conference on Antimicrobial Agents and Chemotherapy(ICAAC)
- Place of Presentation
  San Francisco, CA, US(米国)
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] HIV-1の体内播種とin vivo imaging-12009
- Author(s)
  鍬田伸好、青木宏美、服部真一朗、中村太平、青木学、前田賢次、岡田誠治、満屋裕明
- Organizer
  第23回エイズ学会総会
- Place of Presentation
  名古屋国際会議場、名古屋
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] HIV-1の体内播種とin vivo imaging-22009
- Author(s)
  青木宏美、鍬田伸好、服部真一朗、中村太平、青木学、前田賢次、岡田誠治、満屋裕明
- Organizer
  第23回エイズ学会総会
- Place of Presentation
  名古屋国際会議場、名古屋
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] Degradation of Gag Proteins in Multi -drug-resistant HIV Variants Containing Insertions in Gag Proteins2009
- Author(s)
  天野将之, 〓康博, 田宮貞弘, 満屋裕明
- Organizer
  49th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
- Place of Presentation
  The Moscone Center, San Francisco,CA, USA.
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] ドミノ肝移植にて救命し得たHIV・HCV 重複感染肝不全症例2009
- Author(s)
  宮川寿一、満屋裕明、山本栄和、猪俣裕紀洋、松下修三、塚田訓久、岡慎一
- Organizer
  第23回エイズ学会総会
- Place of Presentation
  名古屋国際会議場、名古屋
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] The binary mechanism of HIV-1 resistance to tipranavir (TPV) : Loss of inhibition of protease catalytic activity and protease dimerization2009
- Author(s)
  Manabu Aoki, Yasuhiro Koh, Kazuhiko Ide, Matthew L. Danish, Hiromi Aoki-Ogata, Hiroaki Mitsuya
- Organizer
  49th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
- Place of Presentation
  The Moscone Center, San Francisco, CA, USA.
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] Macrocyclic Component-containing Protease Inhibitors (PIs) Active Against Multi-PI-Resistant HIV-1 In Vitro2009
- Author(s)
  Yasushi Tojo, Yasuhiro Koh, Debananda Das, Masayuki Amano, Sarang Kulkarni, David Anderson, Arun K. Ghosh, Hiroaki Mitsuya
- Organizer
  49th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
- Place of Presentation
  The Moscone Center, San Francisco, CA, USA.
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] HIV Infection and AIDS : Halt the further spread.2008
- Author(s)
  Mitsuya, H.
- Organizer
  the 13th Congress of the Asia Pacific League of Associations for Rheumatology, Symposium on Infectious Risk in Developing Countries
- Place of Presentation
  横浜
- Year and Date
  2008-11-26
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] Structure-based Development of Antiviral Therapeutics for HIV-1 Infection and AIDS.2008
- Author(s)
  Mitsuya, H.
- Organizer
  International Conference on Drug Design and Discovery for Developing Countries
- Place of Presentation
  Trieste, Italy
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] Anti-HIV Drugs : Past, Present, and Medicinal Challenges.2008
- Author(s)
  Mitsuya, H.
- Organizer
  American Chemical Society 236th National Meeting, Symposium Honoring Victor Marquez for His Contributions to Conformational Analysis, Nucleosides, Nucleotides and Oligonucleotides
- Place of Presentation
  Philadelphia, U.S.A.
- Year and Date
  2008-08-18
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] Development of Antiviral Therapy of HIV Infection : From AZT to Darunavir.2008
- Author(s)
  Mitsuya, H.
- Organizer
  American Chemical Society 236th National Meeting, Robertson and Scarborough Awards Symposium
- Place of Presentation
  Philadelphia, U.S.A.
- Year and Date
  2008-08-18
- Data Source
  KAKENHI-PROJECT-20390288
[Presentation] Dimerization of HIV-1Protease Occurs through Two Steps, Which Relates to the Mechanism of Protease to the Mechanism of Protease Dimerization Inhibition by Darunavir
- Author(s)
  林　宏典、満屋裕明
- Organizer
  15th Kumamoto AIDS Seminar
- Place of Presentation
  阿蘇グランヴィリオホテル（熊本県阿蘇市）
- Year and Date
  2014-10-01 – 2014-10-03
- Data Source
  KAKENHI-PROJECT-26293239
[Presentation] HIV-1プロテアーゼ (PR) の二量体化は2ステップで起こりダルナビルのPR二量体化阻害は最初のステップで起こる
- Author(s)
  林宏典、高宗暢暁、韮澤崇、青木学、森下宣彦、Debanannda Das、閌康博、三隅将吾、満屋裕明
- Organizer
  第16回白馬シンポジウムin熊本
- Place of Presentation
  熊本大学（熊本市中央区）
- Year and Date
  2014-06-13 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-26293239
[Presentation] HIV-1プロテアーゼ（PR）の二量体化は2ステップで起こりdarunavirのPR二量体化阻害は最初のステップで起こる
- Author(s)
  林宏典、高宗暢暁、韮澤崇、青木学、森下宣彦、Debanannda Das、閌康博、三隅将吾、満屋裕明
- Organizer
  第28回エイズ学会総会
- Place of Presentation
  大阪国際会議場（大阪市北区）
- Year and Date
  2014-12-03 – 2014-12-05
- Data Source
  KAKENHI-PROJECT-26293239
[Presentation] 高い中枢神経系 (CNS) 移行性と強力な抗HIV-1活性を有する新規HIV関連神経認知障害 (HAND) 予防/治療薬の開発
- Author(s)
  天野将之、Pedro Miguel Salcedo-Gomez、Arun K. Ghosh、満屋裕明
- Organizer
  第24回抗ウイルス療法研究会総会
- Place of Presentation
  ハイランドリゾートホテル（山梨県富士吉田市）
- Year and Date
  2014-05-07 – 2014-05-08
- Data Source
  KAKENHI-PROJECT-26293239
[Presentation] 多剤耐性HIV-1変異体に強力な活性を発揮する新規プロテアーゼ阻害剤
- Author(s)
  青木学、林宏典、Ravikiran S. Yedidi、Debananda Das、青木宏美、Cuthbert D. Martyr、Arun K. Ghosh、満屋裕明
- Organizer
  第24回抗ウイルス療法研究会総会
- Place of Presentation
  ハイランドリゾートホテル（山梨県富士吉田市）
- Year and Date
  2014-05-07 – 2014-05-08
- Data Source
  KAKENHI-PROJECT-26293239
[Presentation] HIV-1の高度darunavir耐性発現にはdarunavir高感受性を単独で付与するV32Iの獲得が重要である
- Author(s)
  青木学、満屋裕明
- Organizer
  第16回白馬シンポジウムin熊本
- Place of Presentation
  熊本大学（熊本市中央区）
- Year and Date
  2014-06-13 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-26293239

1. 宮川寿一 (40347000)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. MATSUSHITA Shuzo (00199788)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 青木学 (70389542)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. GHOSH Arun K.

# of Collaborated Projects: 2 results

# of Collaborated Products: 49 results
5. KOVARI Ladislau

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. UCHIYAMA Takashi (80151900)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KOYANAGI Yoshio (80215417)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HORI Toshiyuki (70243102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. IWAKURA Yoichiro (10089120)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. BABA Masanori (70181039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TANAKA Yuetsu (30163588)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. FUJII Nobutaka (60109014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 西村泰治 (10156119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 吉良潤一 (40183305)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 根木昭 (00189359)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 入江厚 (30250343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 松下祥 (50167649)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 松見信太郎 (60295152)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 高折晃史 (20324626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 永井美之 (20022874)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 志田壽利 (00144395)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 高松純樹 (80221365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. ARNOLD Eddy

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. ARNORLD Eddy

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 天野将之

# of Collaborated Projects: 0 results

# of Collaborated Products: 9 results
26. 児玉栄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
27. 林宏典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 中田浩智

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 高宗暢暁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MITSUYA HIROAKI 満屋 裕明

MITSUYA Hiroaki 満屋 裕明

MITUYA Yoshiaki 満屋 裕明

Research Projects

Research Products

Co-Researchers

ハロゲン修飾を介したブースター不要抗COVID-19治療薬のデザイン・合成と臨床開発Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Development of a long-acting halogenated HBV capsid inhibitor that is potent against drug-resistant HBV mutantsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of mechanism of HIV resistance to integrase strand transfer inhibitors (INSTI) aiming at development of INSTI-resistance-repellant therapeuticsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Protease inhibitors exerting potent activity against wild type and multi-drug resistant HIV-1 variants without boosters.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of Halogen-Containing Compounds Potent against Wild-type and Multidrug-Resistant HIV-1 StrainsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the mechanism of HIV-1's drug resistance against protease inhibitors using crystal structure and thermodynamic analysesPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Development of Novel HIV-1 Protease Dimerization Inhibitors Using Crystal Structure, Thermal Stability and Mass Spectrum AnalysesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The molecular mechanism of HIV-1's drug resistance against protease inhibitors including darunavir and the development of novel resistance-repelling protease inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural analysis of HIV integrase multimerization and development of inhibitors of integrase interactions with cellular cofactosPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

The analysis of HIV-protease dimerization mechanism at atomic andmolecular resolution, and the design of novel dimerization inhibition compounds.Principal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Elucidation of the Emergence of HIV-1 Variants Resistant to HIV-1 Protease Dimerization Inhibitors (PDIs) and Development of Novel, Potent PDIsPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Analysis of the early phase dynamics of HIV-1 infection in hPBM-transplanted SCID mice using infectious HIV-1 carrying fluorescent protein mCherry and changes with anti HIV drug administrationPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

赤色蛍光発光HIVとその感染細胞の生体内播種・感染拡大の分子イメージング動態解析Principal Investigator

Principal Investigator

MITSUYA HIROAKI 満屋裕明

MITSUYA Hiroaki 満屋裕明

MITUYA Yoshiaki 満屋裕明