Iwakura Yoichiro 岩倉洋一郎

… Alternative Names

IWAKURA Yoichiro 岩倉洋一郎

岩倉洋一朗イワクラヨウイチロウ

Less

Researcher Number	10089120
Other IDs
External Links
Affiliation (Current)	2023: 東京大学, 大学院農学生命科学研究科(農学部), 名誉教授
Affiliation (based on the past Project Information) *help	2023: 東京大学, 大学院農学生命科学研究科(農学部), 名誉教授 2015 – 2022: 東京理科大学, 研究推進機構生命医科学研究所, 教授 2011 – 2016: 東京理科大学, 付置研究所, 教授 2012 – 2014: 東京理科大学, 生命医科学研究所, 教授 2012: 東京理科大学生命医科学研究所, 生命医科学研究所, 教授 … More 1992 – 2011: 東京大学, 医科学研究所, 教授 2007: The Institute of Medical Science, Professor 2000: 東京大学, 医学科研究所, 教授 2000: University of Tokyo, Institute of Medical Science, Professor, 医科学研究所・ヒト疾患モデル動物センター, 教授 1998: 東京大学, 医科学研究科, 教授 1994: 東京大学, 医科研, 教授 1988 – 1992: 東京大学, 医科学研究所, 助教授 1989: 東京大学, 医学研究所・ウイルス部, 助教授 1989: 東京大学, 医科学研究所ウイルス感染研究部, 助教授 1988: 東京大学, 医科学研究所・ウイルス感染部, 助教授 1987: 東京大学, 医科学研究所, 教授 1987: 東京大学, 医科学研究所・ウィルス感染部, 助教授 1986: 東京大学, 医学部研究所・ウィルス感染部, 助教授 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Laboratory animal science / Laboratory animal science / Virology / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Basic Section 42040:Laboratory animal science-related / Complex systems / Basic Section 49070:Immunology-related / Immunology / Immunology … More Except Principal Investigator … More Biological Sciences / Basic Section 42040:Laboratory animal science-related / Neuroscience in general / Ophthalmology / Laboratory animal science / Applied veterinary science / Laboratory animal science / Basic veterinary science/Basic zootechnical science / Immunology / Parasitology (including Sanitary zoology) / Functional biochemistry / Virology / 寄生虫学(含医用動物学) / Immunology / Hematology / Applied animal science / 畜産学(含草地学) / Laboratory animal science / Bacteriology (including mycology) / Bacteriology (including Mycology) Less
Keywords	Principal Investigator サイトカイン / 関節リウマチ / トランスジェニックマウス / ノックアウトマウス / IL-1 / HTLV-I / 自己免疫 / IL-6 / 自己免疫疾患 / インターフェロン … More / C型レクチン / マイクロアレイ / IL-1レセプターアンタゴニスト / 疾患モデル動物 / 遺伝子欠損マウス / 遺伝子改変マウス / 自然免疫 / 免疫学 / マウス / 標的遺伝子組換え / Autoimmune / IL-17 / 炎症性疾患 / 疾患モデルマウス / 樹状細胞 / 関節炎 / 発癌 / コラーゲン誘導関節炎 / インターロイキン-1 / HTLV-1 / 腫瘍 / TNF-α / 疾患モデル / HTLV-I-Tgマウス / Disease model / Tax / Cytokine / Inflammation / Transgenic mouse / Arthritis / C型レクチン受容体 / CTRP / Th17 / 獲得免疫 / 連鎖解析 / ゲノム / モデルマウス / IL-1Rアンタゴニスト / 発生工学 / 遺伝子 / 免疫応答 / HIV / エイズ / IFN-γ / エンドトキシンショック / IL-1 receptor antagonist / IL-1 signal / negative selection / 実験動物学関連 / PAQR / 多発性硬化症 / 腎炎 / PAQR 受容体 / CTRP ファミリー分子 / 腫瘍形成制御機構 / 線維化 / アレルギー / 炎症 / DSS誘発性大腸炎 / アレルギー性気道炎症（AAI） / Gene knockout mice / 感染防御 / 腸管免疫 / シングルセル / 免疫疾患 / 腸内細菌叢 / 大腸がん / Innate immunity / C-type lectin / Dendritic Cells / Inflmmation / Rheumatiod arthritis / cvtokine / Animal disease models / IL-1R antagonist / Animal Models1 / Rheumatoid Arthritis / IL-IRアンタゴニスト / model mice / antoimmune disease / knockout mice / transgenic mice / Rheumatoid arthritis / コンジェニック / 病態モデルマウス / HIV-I-Tgマウス / IL-12 / HTLV-I Tgマウス / HIV-Tgマウス / HTLV-L Tgマウス / IL-1β / IL-1α / 成人T細胞白血病ウイルス(HTLV-I) / 自己抗体 / Cytekine / 精子形成 / メタロチオネイン / 実験動物 / C1qTNF / Th17鈿胞 / 間接リウマチ / Th17細胞 / 自己応答性 / IL-17F / IL-17A / 慢性関節リウマチ / 生体防御 / 細菌感染 / 応用植物 / 発生・分化 / シグナル伝達 / 細胞・組織 / 応用動物 / 病態モデル動物 / ウイルス / OX40 / CD40L / トランジェニックマウス / T細胞 / アレルギー・ぜんそく / 遺伝要因 / 抗体産生 / CXCR4 / loxpシステム / Cre / ケモカイン / 慢性関節炎 / IFN-γレセプター / B16メラノーマ / ConA誘導肝炎 / 炎症性発熱 / インターフェロンγ / インターロイキン1 / 標的遺伝子組み換え / 検索 / システム / コンピューター / ソフト / 維持 / 管理 / ConA肝炎 / ES細胞 / 遺伝子相同組換え / 遺伝子標的法 / 癌抑制遺伝子 / 癌 … More Except Principal Investigator トランスジェニックマウス / ノックアウトマウス / サイトカイン / C型レクチン / 癌遺伝子 / 自然免疫 / 体外受精 / 自己免疫疾患 / 受精 / C型レクチン受容体 / 遺伝子改変マウス / 真菌感染 / 樹状細胞 / 標的遺伝子組換え / 胚培養 / 相同遺伝子組換え / ES細胞 / マウス / 形質転換動物 / ヒト疾患モデル / 生物機能モデル / 自然免疫受容体 / NO / MyD88 / interferon gamma / インターフェロンガンマ / トキソプラズマ / LTR / HIV / B-1細胞 / SDF-1 / TAG-1 / Inflammation / 関節リウマチ / IL-1 / コンタクチン / IL-3 / アポトーシス / STAT5 / 発生工学 / Toxoplasma / トキソプラズマ原虫 / バベシア原虫 / chimeras / parthenogenesis / endothelin / acrosin / fertilization / oocyte maturation / 減数分裂 / 卵丘 / 遺伝子発現 / キメラ胚 / 単為発生 / アクロシン / 卵成熟 / 遺伝子改変動物 / C-type lectin / 炎症反応 / 獲得免疫 / 感染防御 / 感染免疫 / 腫瘍免疫 / 炎症 / 初期胚 / セレクチン / ガラクトース転移酵素 / 疾患モデル / シグナル伝達 / マウスエイズ / ネコ免疫不全ウイルス / サル免疫不全ウイルス / 遺伝子解析 / キメラマウス / 遺伝子トラップ / 多段階発癌 / 再構成卵巣 / 哺乳動物初期胚 / T細胞受容体遺伝子再配列 / 成人性T細胞白血病 / 発癌遺伝子 / animal model / AdipoR / Paqr / CTRP / CRISPR-Cas / Dectin-1 / 腸管免疫 / 真菌 / 抑制型C型レクチン受容体 / 炎症・がん / DAMP / 免疫原性核酸 / がん / HMGB1 / 恒常性維持 / 免疫シグナル伝達 / Innate immunity / Autoimmune / Dendritic cells / Rheumatoid arthritis / cytokine / Animal disease models / 網羅的解析 / 炎症性疾患 / 疾患モデル動物 / 自己免疫 / B-1 effector cells / acquired immunity / innate immunity / systemic erthetodes / Toll like receptor(TLR) / T.gondii-derived HSP70(TgHSP70) / 抑制性B-2細胞 / IRAK4 / TLR4 / TLR2 / ループス腎炎 / B-2抑制性細胞 / 全身性エリトマトーデス / B-1エフェクター細胞 / 自然免疫と獲得免疫 / TgHSP70 / トキソプラズマ毒性分子 / 全身性エリテマトーデス / NO産生 / Toll-like receptor / トキソプラズマ由来ストレス蛋白TgHSP70 / retinal vasculitis / uveitis / micro array / toxoplasmic retinochoroiditis / トキソプラズマ性網脈絡膜炎 / 網膜血管炎 / ブドウ膜炎 / マイクロアレイ / トキソプラズマ件網脈絡膜炎 / Genetic altered animals / Knockout / Embryonic Srem cell / ノックアウト / TRANSGENIC MICE / OSTEOCLASTOGENESIS INHIBITORY FACTOR / OSTEOCLAST DIFFERENTIATION FACTOR / OSTEOCLASTS / BONE DESTRUCTION / 破骨細胞形成抑制因子 / 破骨細胞分化因子 / 破骨細胞 / 骨破壊 / interferon gamma knock out mouse / organ specificity / heat shock protein / chorioretinitis / インターフェロンガンマノックアウトマウス / 臓器特異性 / 熱ショック蛋白 / 網脈絡膜炎 / Latent Infection / CpG Methylation / Transcription / 細胞内シグナル伝達 / 潜伏HIV再活性化シグナルによるLTRの脱メチル化制御 / ヌクレオソーム / クロマチン免疫沈降法 / Histone Code / 潜伏感染 / 転写抑制 / 潜状感染 / CpGメチル化 / 転写 / VTR / IFN-γ knockout (KO) mice / SAG1 / T.g.HSP30 / T.g.HSP70 / T.gondii stress protein HSP70 / cDNA microarray / Toxoplasma gondi / danger signal / IFN-γ / マイクロアレー / TgHSP30遺伝子 / TgHSP70遺伝子 / testesterone / RAG遺伝子 / HSP70自己抗体 / IFN-γKOマウス / SAG1遺伝子 / T.g.HSP30遺伝子 / T.g.HSP70遺伝子 / トキソプラズマ原虫ストレス蛋白HSP70 / cDNAマイクロアレイ / scid mice / stem cell / transgenic mice / 血液幹細胞 / ケモカイン / expression / Lac Z gene / motor coordination / behavior / NB-3 deficient mice / cell adhesion molecule / contakutin subgroup / 遺伝子変異マウス / NB-3 / 発現 / LacZ遺伝子 / 運動機能障害 / 行動実験 / NB-3欠損マウス / 神経接着分子 / コンタクチンサブグループ / Adenosine / axon guidance / Knockout mouse / Gene targeting / アデノシン / 免疫グロブリンスーパーファミリー / 脳神経細胞 / 細胞接着分子 / Apoptosis / Stress Response / RheumatoidArthritis / Contact Hypersensitivity / Antibody Production / Knockout mice / エンドトキシンショック / ディファレンシャル・ディスプレイ / 細菌誘導性肝炎 / T細胞フライミング / ストレス応答 / 接触過敏症反応 / 抗体産生 / Reverse transcriptase inhibitor / Neutralizing antibody / Vpr transgenic mouse / Membrane fusion inhibitor / CXCR4 inhibitor / Drug resistance / CCR5 inhibitor / Protease inhibitor / u-CRM1 / rev / フィットネス / 転写制御 / tat / CTL / 抗ウイルス剤 / 発症予防ワクチン / ケモカインレセプター阻害剤 / hu-PBL-SCIDマウス / 遺伝子発現制御 / CXCR4拮抗剤 / T140 / HIV-1 / 逆転写酵素阻害剤 / 中和抗体 / Vprトランスジェニックマウス / 膜融合阻害剤 / CXCR4阻害剤 / 薬剤耐性 / CCR5阻害剤 / プロテアーゼ阻害剤 / 神経細胞 / 接着分子 / Proliferation / Differentiation / Apotosis / Transcription factor / Cytokine receptor / Cytokine / サイトカインレセプター / 増殖 / 分化 / 転写因子 / サイトカインセプター / developmental engineering / Monoclonal antibody / diagnostic antigens / gene engineering / recombinant antigen / cytokine knock-out mice / protective immunity / Babesia parasites / 防御抗原 / ELISA / イヌバベシア / ウマバベシア / マウスバベシア / モノクローナル抗体 / 診断用抗原 / リコンビナント抗原 / 防御免疫 / サイトカインノックアウトマウス / mouse / Trypanosoma / Babesia / Interferon / Scavenger receptor / macrophage / Transgenic / ネオスポーラ原虫 / インターフエロン / 遺伝子導入 / トリパノソーマ原虫 / インターフェロン / スカベンジャー受容体 / マクロファージ / Gonad / Implantation / Fertilization / Embryo differentiation / Embryo manipulation / Reproduction / Gene targetting / Transgenic animal / トランスジェニック動物 / 性腺 / 着床 / 胚分化 / 初期胚操作 / 生殖 / ジーンターゲティング / embryo freezing / c-mos / PCR / 性比 / 初期発生 / c-mos遺伝子 / 遺伝子ターゲット法 / 胚の凍結保存 / c-mos 遺伝子 / 遺伝子ターゲット / adenovirus / cyclin / ベータガラクトシダーゼ / メタロチオネイン / 顕微注入 / レポーター遺伝子 / 性判別 / 性分化 / アデノウイルスベクター / エンドセリン / サイクリン / チミヂンキナーゼ遺伝子 / グロビン / F9細胞 / 胚の分化と増殖 / 胚割球の分離 / 体外培養 / カニクイザル / 染色体外環状DNA / TNF / HIV-1 tatIII / HTLV-1 tax-1 / 生殖系列 / 人小細胞肺癌 / ヒト成人性T細胞白血病 / DNAートランスフェクション / pXーII遺伝子 / HTLVーII / pXーI遺伝子 / HTLVー / 腫瘍遺伝子 / 細胞工学方法 / 核移植細胞 / テラトカルシノーマ / リガンド / DCIR / Ｃ型レクチン受容体 / レクチン / 骨代謝 / 細菌感染 / 真菌感染防御 / ｻｲﾄｶｲﾝ / 疾患モデルマウス / Th17 / T細胞 / 肥満 / インスリン / 脂肪細胞 / siRNA / データベース / 再プログラム化 / Nanog / 4 / Oct-3 / 多能性 / 神経幹細部 / 遺伝子 / 発生・分化 / 再生医学 / 遅延型接触過敏症反応 / 胎生致死 / 成長遅延 / 分子進化 / cDNA突然変異誘発法 / 白血病抑制因子 / 胎盤性ラクトジェン / 絨毛性性腺刺激ホルモン / 糖鎖 / 血球分化 / 造血幹細胞 / MDS / 白血病 / 変異G-CSFR / Kostmann症候群 / G-CSF受容体(G-CSFR) / チロシンキナーゼ / ネコ免疫不全ウィルス / サル免疫不全ウィルス / ヒト免疫不全ウィルス / 後天性免疫不全症 / ヒト免疫不全ウイルス / スキッドマウス / キメラウイルス / 癌抑制遺伝子 / 動物モデル / エイズ / 組換えウイルス / HTLVI / トランスサイレチン / 遺伝子欠損モデル / 胚幹細胞 / ジーンターゲッティング / 遺伝子治療 / 遺伝子診断 / 病因変異 / 遺伝子単離 / 分子生物学 / 単一遺伝子病 / 癌抑制院伝子 / 相同的組替え / 核移植 / 遺伝子導入動物 / 胚奇形腫 / 始原生植細胞 / 高脂血症 / 高血圧 / 標的遺伝子置換法 / ジ-ンタ-ゲッティング / モデル動物 / 分化遺伝子 / ウシ / サル / テラト-マ / キメラ / ジ-ンタ-ゲッティング法 / 高血圧症モデル / 家族性アミロイドニュ-ロパシ- / インターフェロン遺伝子 / 成長ホルモン遺伝子 / 共培養 / 遺伝子標的導入法 / アンチセンス / 家族性アミロイドポリニューロパチー / vーmos / cーfos / HIVーtatIII遺伝子 / HTLVーI taxー1遺伝子 Less

腎尿細管間質病変の進行における CTRP6-PAQR シグナル伝達経路の役割
- Principal Investigator
  
  紀熙華
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Tokyo University of Science
Mechanisms of autoimmunity induced by excess IL-1 signalingPrincipal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  The University of Tokyo
Functional analysis of CTRP3, CTRP6 and their receptors using gene targeted micePrincipal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  The University of Tokyo
  Tokyo University of Science
Analysis of inflammation, allergy, fibrosis, and tumorigenesis through the innate immune systemPrincipal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tokyo University of Science
Generation of gene-modified mice by targeting on innate immune receptor family and analysis of the function of these receptors by using human disease-models.
- Principal Investigator
  
  唐策
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Tokyo University of Science
真菌感染現象における抑制型C型レクチン受容体の生理機能の解明
- Principal Investigator
  
  矢部力朗
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Chiba University
自然免疫受容体を介した腸管免疫の制御と全身免疫への影響の解析Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Tokyo University of Science
Analysis of physiological function of C-type lectin receptor and application to disease controlPrincipal Investigator
- Principal Investigator
  
  Iwakura Yoichiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Tokyo University of Science
Elucidation of the host's homeostatic responses by the regulation of immune system and its application to the prevention and treatment of immunological disorders
- Principal Investigator
  
  Taniguchi Tadatsugu
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
Anti-fungal Immunity
- Principal Investigator
  
  Saijo Shinobu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Chiba University
The physiological functions of a C-type lectin receptor and the relation with diseases
- Principal Investigator
  
  KAIFU Tomonori
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Tohoku Medical and Pharmaceutical University
  Tokyo University of Science
Establishment of an IL-1-related gene-manipulated mouse library and dissection of the gene-targeted mice, aiming at identifying new therapeutic targets for diseasesPrincipal Investigator
- Principal Investigator
  
  Iwakura Yoichiro
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Laboratory animal science
- Research Institution
  Tokyo University of Science
創薬標的の探索を目指したIL-1関連遺伝子改変マウスライブラリーの作製研究Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  Tokyo University of Science
The role of C-type lectins in the host defense against fungal infections
- Principal Investigator
  
  SAIJO Shinobu
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Chiba University
Establishing a new animal model for ankylosing spondylolysis using DCIR deficient mice
- Principal Investigator
  
  KAIFU Tomonori
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Tokyo University of Science
  The University of Tokyo
真菌感染防御におけるC型レクチンの役割
- Principal Investigator
  
  西城忍
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
  The University of Tokyo
炎症性サイトカインとC型レクチンによる発がん制御機構の解析
- Principal Investigator
  
  角田茂
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Establishment of an IL-1-related gene-manipulated mice library, aiming at uncovering pathophysiology of disease from a view point of systems biologyPrincipal Investigator
- Principal Investigator
  
  IWAKURA Yoichiro
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo
疾患のシステム的理解を目指したIL-1関連遺伝子欠損マウスライブラリーの作製Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo
インターロイキン17/17Fによる細菌感染防御機構の解析Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
The roles of cytokines in the development of autoimmune deseasesPrincipal Investigator
- Principal Investigator
  
  IWAKURA Yoichiro
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
骨・軟骨の恒常性維持におけるケモカイン及びC型レクチンの役割の解明Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
脂肪細胞から分泌されるlL-1Raの役割
- Principal Investigator
  
  千田大
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
自己免疫性関節炎発症における樹状細胞の役割Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Roles of dendritic cells in the development of autoimmune arthropathyPrincipal Investigator
- Principal Investigator
  
  IWAKURA Yoichiro
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
Analysis of genes involved in the pathogenesis of the arthritis using animal disease models..
- Principal Investigator
  
  SAIJO Shinobu
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo
関節リウマチの遺伝的要因の解析Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
自己免疫性関節炎発症における樹状細胞の役割Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
慢性関節リウマチの遺伝的要因の解析Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
HTLV-Iによる自己免疫性慢性関節炎発症機構の解明Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
体細胞初期化誘導および未分化維持に関するシグナル因子の解析
- Principal Investigator
  
  角田茂, 須藤カツ子
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Interplay between TLR-mediated innate immunity, acquired immunity and in Toxoplasma gondii-derived heat shock protein, TgHSP70, in toxoplasmosis
- Principal Investigator
  
  YANO Akihiko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Parasitology (including Sanitary zoology)
- Research Institution
  Chiba University
疾患モデルマウスを用いた関節リウマチの遺伝的要因の解析Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
HTLV-Iによる自己免疫性慢性関節炎発症機構の解明Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
cDNA microarray analysis of toxoplasmic retinochoroiditis
- Principal Investigator
  
  NOROSE Kazumi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Chiba University
IL-1による免疫応答制御機構の解明Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
関節リウマチの遺伝要因の解明Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
インターフェロン・サイトカインの抗癌作用の研究Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
HTLV-Iによる自己免疫性慢性関節炎発症機構の解明Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
A STUDY ON THE CONTROL OF BONE DESTRUCTION USING OSTEOCLAST DIFFERENTIATION FACTOR AS A TARGET
- Principal Investigator
  
  YASUDA Hisataka
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  THE UNIVERSITY OF TOKYO
Establishment of ES cell lines derived from several inbred strains
- Principal Investigator
  
  SUDO Katsuko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo
IL-1による免疫応答制御機構の解明Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
関節リウマチの遺伝要因の解明Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
インターフェロン・サイトカインの抗癌作用の研究Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
The roles of cytokines on the development of rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  IWAKURA Yoichiro
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
Establishment of in-house cDNA microarray for analysis of pathogenicity of Toxoplasma gondii infection and developing methods of diagnosis and therapy for toxoplasmosis
- Principal Investigator
  
  YANO Akihiko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  寄生虫学(含医用動物学)
- Research Institution
  Chiba University
Regulation Mechanisms of HIV LTR Demethylation through Reactivation Signaling
- Principal Investigator
  
  ISHIDA Takaomi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  The University of Tokyo
Effect of Heart Shock Protein and Interferon on Toxoplasmic Chorioretinitis
- Principal Investigator
  
  NOROSE Kazumi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  CHIBA UNIVERSITY
インターフェロン・サイトカインの抗癌作用の研究Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
ヒトT細胞白血病ウイルスによる自己免疫発症機構の解析Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
ガラクトース転移酵素遺伝子ノックアウトマウスを用いた糖鎖機能の解析
- Principal Investigator
  
  浅野雅秀
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kanazawa University
発生工学的手法によるエイズ制圧の試みPrincipal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
発生工学的手法を用いたケモカインによる造血分化決定機構の解析Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Production and Analysis of TAG-1 Knockout Mouse
- Principal Investigator
  
  FUKAMAUCHI Fumihiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  Tokyo Medical and Dental University
Generation and analysis of NB-3 deficient mice
- Principal Investigator
  
  WATANABE Kazutada
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
A trial to generate recipient mice which support the development of human hematopoietic stem cells to T-lymphocytes
- Principal Investigator
  
  SUDO Katsuko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo
ヒトT細胞白血病ウイルスによる自己免疫発症機構の解析Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
ガラクトース転移酵素遺伝子ノックアウトマウスを用いた糖鎖機能の解析
- Principal Investigator
  
  浅野雅秀
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
発生工学的手法によるエイズ制圧の試みPrincipal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Basic Research for AIDS control A03 ; Prevention and control of AIDS
- Principal Investigator
  
  MATSUSHITA Shuzo
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  KUMAMOTO UNIVERSITY
Development of rheumatoid arthritis models using transgenic techniquePrincipal Investigator
- Principal Investigator
  
  IWAKURA Yoichiro
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo
Functional analysis of IL-1 in immune and stress responses using gene knockout mice
- Principal Investigator
  
  ASANO Masahide
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Kanazawa University
  The University of Tokyo
インターフェロンによるアポトーシスの誘導と発がん抑制Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
ヒトG-CSFレセプタートランスジェニックマウスを用いた白血病発症機構の研究
- Principal Investigator
  
  中畑龍俊
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
ヒト細胞白血病ウィルスによる自己免疫症機構の解析Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
糖鎖による情報積載の分子発達：糖タンパク質の機能と構造
- Principal Investigator
  
  小川智也
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  The University of Tokyo
Analysis on protective antigen of Babesia parasites by developmental engineering
- Principal Investigator
  
  IGARASHI Ikuo
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Applied veterinary science
- Research Institution
  Obihiro University Agriculture and Veterinary Medicine
Activation of cytokine signaling by constitutively active STAT5.
- Principal Investigator
  
  KITAMURA Toshio
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
ジーンターゲティングによるコンタクチン遺伝子欠損マウスの作製と解析
- Principal Investigator
  
  FUKAMAUCHI Fumihiko
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  Tokyo Medical and Dental University
標的遺伝子組み換え法によるサイトカインの炎症反応における役割の解析Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
ヒトT細胞白血病ウイルスによる自己免疫発症機構の解析Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Deveropmental biotechnological analysis of host defense mechanisms against protozoan infection
- Principal Investigator
  
  TOYODA Yutaka
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied veterinary science
- Research Institution
  OBIHIRO UNIVERSITY OF AGRICULTURE AND VETERINARY MEDICINE
サイトカイン研究のための遺伝子改変マウスライブラリーの作製Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo
標的遺伝子組み換え法を用いたサイトカインの生理機能の解析Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
エイズの病態と制御に関する基礎研究エイズの動物モデル
- Principal Investigator
  
  速水正憲
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
遺伝子導入マウスのコンピューターによる維持・管理システムの開発Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo
単一遺伝子病の分子・細胞生物学的研究
- Principal Investigator
  
  多田啓也, 勝木元也
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
  Kyushu University
エイズ制圧に向けての基礎研究・エイズの動物モデル
- Principal Investigator
  
  速水正憲
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
標的遺伝子組換え法を用いたサイトカインの生理機能の解析Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
遺伝子導入動物による発癌の研究
- Principal Investigator
  
  樋野興夫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Japanese Foundation For Cancer Research
遺伝子導入動物による発症の研究
- Principal Investigator
  
  山村研一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kumamoto University
トランスジェニックマウスを用いたインターフェロンの癌抑制作用の解析Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
成人T細胞白血病ウイルスによる自己免疫状態の誘導機構に関する研究Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
標的遺伝子組換え法を用いたサイトカインの生理機能の解析Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Biotechnological studies on the mechanisms regulating embryogenesis
- Principal Investigator
  
  TOYODA Yutaka
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
Analysis of reproductive processes by means of transgenic animals
- Principal Investigator
  
  TAKAHASHI Michio
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  The University of Tokyo
遺伝子導入動物による発癌の研究
- Principal Investigator
  
  山村研一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kumamoto University
遺伝子破壊法によるインターフェロンの癌抑制機能の解析Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
Studies on te regulatory mechanisms of gene expression in early embryos
- Principal Investigator
  
  TOYODA Yutaka
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  畜産学(含草地学)
- Research Institution
  The University of Tokyo
Pathogenesis of inflammatory arthropathy developed in HTLV-I transgenic micePrincipal Investigator
- Principal Investigator
  
  IWAKURA Yoichiro
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  The University of Tokyo
遺伝子導入動物による発癌の研究
- Principal Investigator
  
  山村研一
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kumamoto University
外来遺伝子DNA導入による新しいモデル動物の開発
- Principal Investigator
  
  勝木元也
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
初期発生における割球分化の分子機構
- Principal Investigator
  
  入谷明
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
初期発生における割球分化の分子機構
- Principal Investigator
  
  入谷明
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
発癌遺伝子移入による正常造血系細胞のimmortalization
- Principal Investigator
  
  関口豊三
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kohno Clinical Medicine Research Institute
初期発生の分子機構
- Principal Investigator
  
  入谷明
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
発癌遺伝子移入による正常造血系細胞のimmortalzation
- Principal Investigator
  
  関口豊三
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kohno Clinical Medicine Research Institute
個体レベルにおける各種インターフェロンの生物活性の検討Principal Investigator
- Principal Investigator
  
  岩倉洋一郎
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  The University of Tokyo
初期発生の分子機構
- Principal Investigator
  
  入谷明
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
外来遺伝子DNA導入による新しいモデル動物の開発
- Principal Investigator
  
  勝木元也
- Project Period (FY)
  1987 – 1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokai University
外来遺伝子DNA導入による新しいモデル動物の開発
- Principal Investigator
  
  勝木元也
- Project Period (FY)
  1987 – 1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokai University
発癌遺伝子の移入による正常造血系細胞のImmortalizationと癌化
- Principal Investigator
  
  関口豊三
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
生殖系列の分子機構に関する基礎研究
- Principal Investigator
  
  毛利秀雄
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Institution
  The University of Tokyo
細胞工学方法によるテラトカルシノーマの分化誘導と腫瘍遺伝子発現の制御
- Principal Investigator
  
  関口豊三
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East

[Book] 消化器外科 2020年1月号「癌と炎症を学ぶ解説１　IL-17，Th17」2020
- Author(s)
  唐策、岩倉洋一郎
- Total Pages
  128
- Publisher
  へるす出版
- Data Source
  KAKENHI-PROJECT-18H02671
[Book] EXPERT膠原病・リウマチ改訂第4版2019
- Author(s)
  20.角田茂、岩倉洋一郎
- Total Pages
  416
- Publisher
  診断と治療社
- ISBN
  9784787823830
- Data Source
  KAKENHI-PROJECT-15H05787
[Book] 医学のあゆみ　食品成分による腸管Tregの制御2019
- Author(s)
  岩倉洋一郎
- Total Pages
  264
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-18H02671
[Book] 医学のあゆみ　IL-17ファミリー分子の生体における役割2019
- Author(s)
  岩倉洋一郎
- Total Pages
  120
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-18H02671
[Book] トピックス「自己免疫疾患に対する新たな治療標的の発見」2017
- Author(s)
  村山正承、岩倉洋一郎
- Total Pages
  4
- Publisher
  理大科学フォーラム
- Data Source
  KAKENHI-PROJECT-15H05787
[Book] トピックス「自己免疫疾患に対する新たな治療標的の発見」2017
- Author(s)
  村山正承、岩倉洋一郎
- Total Pages
  4
- Publisher
  理大科学フォーラム
- Data Source
  KAKENHI-PROJECT-24220011
[Book] セミナー室「低分子βグルカン摂取により炎症性腸疾患を予防，改善する」2016
- Author(s)
  唐策、角田茂、岩倉洋一郎
- Total Pages
  6
- Publisher
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-15H05787
[Book] セミナー室「低分子βグルカン摂取により炎症性腸疾患を予防，改善する」2016
- Author(s)
  唐策、角田茂、岩倉洋一郎
- Total Pages
  6
- Publisher
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-24220011
[Book] IL-1ファミリー分子による免疫制御2016
- Author(s)
  秋津葵、岩倉洋一郎
- Total Pages
  7
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-15H05787
[Book] Dendritic Cell Immunoreceptor (DCIR): An ITIM-Harboring C-Type Lectin Receptor.2016
- Author(s)
  Tomonori Kaifu and Yoichiro Iwakura.
- Total Pages
  12
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PROJECT-24220011
[Book] 自己免疫性関節炎と病原性T細胞2016
- Author(s)
  秋津葵、岩倉洋一郎
- Total Pages
  5
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-15H05787
[Book] 医歯薬出版株式会社2016
- Author(s)
  秋津葵、岩倉洋一郎
- Total Pages
  5
- Publisher
  自己免疫性関節炎と病原性T細胞
- Data Source
  KAKENHI-PROJECT-24220011
[Book] Dendritic Cell Immunoreceptor (DCIR): An ITIM-Harboring C-Type Lectin Receptor.2016
- Author(s)
  Tomonori Kaifu and Yoichiro Iwakura.
- Total Pages
  12
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PROJECT-15H05787
[Book] IL－1ファミリー分子による免疫制御2016
- Author(s)
  秋津葵、岩倉洋一郎
- Total Pages
  7
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-24220011
[Book] 第1章インターロイキン「IL-18/33/36/37」サイトカイン・増殖因子キーワード事典2015
- Author(s)
  海部知則、岩倉洋一郎
- Total Pages
  3
- Publisher
  洋土社
- Data Source
  KAKENHI-PROJECT-24220011
[Book] 第1章インターロイキン「成長ホルモン」「プロラクチン」サイトカイン・増殖因子キーワード事典2015
- Author(s)
  米沢朋、丸田大貴、岩倉洋一郎
- Total Pages
  5
- Publisher
  洋土社
- Data Source
  KAKENHI-PROJECT-24220011
[Book] 第1章インターロイキン「IL-12」サイトカイン・増殖因子キーワード事典2015
- Author(s)
  矢部力朗、岩倉洋一郎
- Total Pages
  2
- Publisher
  洋土社
- Data Source
  KAKENHI-PROJECT-24220011
[Book] 第1章インターロイキン「IL-19/20/22/24/26」サイトカイン・増殖因子キーワード事典2015
- Author(s)
  神谷知憲、岩倉洋一郎
- Total Pages
  3
- Publisher
  洋土社
- Data Source
  KAKENHI-PROJECT-24220011
[Book] 第1章インターロイキン「IL-14」「IL-16」「IL-32」サイトカイン・増殖因子キーワード事典2015
- Author(s)
  村山正承、岩倉洋一郎
- Total Pages
  3
- Publisher
  洋土社
- Data Source
  KAKENHI-PROJECT-24220011
[Book] 第1章インターロイキン「IL-17A/17B/17C/17D/17E/17F」サイトカイン・増殖因子キーワード事典2015
- Author(s)
  秋津葵、岩倉洋一郎
- Total Pages
  3
- Publisher
  洋土社
- Data Source
  KAKENHI-PROJECT-24220011
[Book] Current Topics. デクチン1シグナルの阻害は、腸内乳酸桿菌を増殖させ、制御性Ｔ細胞を増加させることによって、大腸炎を抑制する」実験医学20162015
- Author(s)
  唐策、岩倉洋一郎
- Total Pages
  4
- Publisher
  洋土社
- Data Source
  KAKENHI-PROJECT-24220011
[Book] 第1章インターロイキン「IL-23/35」サイトカイン・増殖因子キーワード事典2015
- Author(s)
  唐策、岩倉洋一郎
- Total Pages
  3
- Publisher
  洋土社
- Data Source
  KAKENHI-PROJECT-24220011
[Book] 【大学発日本人と技術】日本を支える研究活動と技術開発関節リウマチの新たな治療薬開発2015
- Author(s)
  村山正承、岩倉洋一郎
- Total Pages
  1
- Publisher
  フジサンケイビジネスアイ
- Data Source
  KAKENHI-PROJECT-24220011
[Book] 第2章インターフェロン「概論」「IFN-α/β」「IFN-γ」「IFN-λファミリー（IL-28, IL-29）」サイトカイン・増殖因子キーワード事典2015
- Author(s)
  角田茂、岩倉洋一郎
- Total Pages
  10
- Publisher
  洋土社
- Data Source
  KAKENHI-PROJECT-24220011
[Book] 第1章インターロイキン「IL-10」サイトカイン・増殖因子キーワード事典2015
- Author(s)
  鄭琇絢、岩倉洋一郎
- Total Pages
  3
- Publisher
  洋土社
- Data Source
  KAKENHI-PROJECT-24220011
[Book] 第1章インターロイキン「IL-1」サイトカイン・増殖因子キーワード事典2015
- Author(s)
  清水謙次、岩倉洋一郎
- Total Pages
  3
- Publisher
  洋土社
- Data Source
  KAKENHI-PROJECT-24220011
[Book] 実験医学増刊、炎症―全体像を知り慢性炎症を制御するー2014
- Author(s)
  矢部力朗、岩倉洋一郎、西城忍
- Total Pages
  219
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-24220011
[Book] サイトカインと自己免疫疾患．EXPERT膠原病・リウマチ　改訂第３版（住田孝之編）2013
- Author(s)
  角田茂、岩倉洋一郎
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-24220011
[Book] 炎症性サイトカインと骨破壊2012
- Author(s)
  海部知則, 岩倉洋一郎
- Publisher
  医学のあゆみ
- Data Source
  KAKENHI-PROJECT-23500489
[Book] 遺伝子改変動物.新しい薬学事典2012
- Author(s)
  角田茂、岩倉洋一郎
- Publisher
  朝倉書店(印刷中)
- Data Source
  KAKENHI-PROJECT-20220009
[Book] IL-1. seriesモデル動物利用マニュアル免疫疾患-疾患モデルの作製と利用2011
- Author(s)
  角田茂、岩倉洋一郎
- Publisher
  エル・アイ・シー
- Data Source
  KAKENHI-PROJECT-20220009
[Book] 免疫疾患.疾患モデルの作製と利用.シリーズ「モデル動物利用マニュアル」2011
- Author(s)
  岩倉洋一郎
- Total Pages
  580
- Publisher
  エル・アイ・シー
- Data Source
  KAKENHI-PROJECT-20220009
[Book] 発刊にあたって.免疫疾患-疾患モデルの作製と利用.シリーズモデル動物利用マニュアル2011
- Author(s)
  岩倉洋一郎
- Total Pages
  580
- Publisher
  エル・アイ・シー
- Data Source
  KAKENHI-PROJECT-20220009
[Book] 遺伝子改変マウス."哺乳動物の分子生物学"を切り拓いた技術バイオテクノロジーの温故知新2011
- Author(s)
  岩倉洋一郎
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-20220009
[Book] アグリゲーション法によるキメラマウスの作製.改訂第5版新遺伝子工学ハンドブック2010
- Author(s)
  角田茂、佐藤希、久保幸子、岩倉洋一郎
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-20220009
[Book] Dcirと自己免疫疾患最新医学2009
- Author(s)
  藤門範行、岩倉洋一郎
- Data Source
  KAKENHI-PROJECT-20220009
[Book] サイトカインシグナルと代謝疾患2008
- Author(s)
  千田大、岩倉洋一郎
- Publisher
  ニュー・サイエンス社
- Data Source
  KAKENHI-PROJECT-20220009
[Book] nterleukin-1 deficiency and aggressiveness in male mice.(M.T. Czerbnska ed., Psychoneuroendocrinology Research Trends)2007
- Author(s)
  Tamagawa, A., Kolosova, I., Endo, Y., Gerlinskaya, L., Iwakura, Y., Moshikin, M.
- Publisher
  Nova Science Publishers, Inc.
- Data Source
  KAKENHI-PROJECT-19059006
[Book] The roles of IL-17A and IL-17F in mucosal infection and allergy.(ed. S. Jiang, Th17 cells in health and disease)
- Author(s)
  Ishigame, H., Nakae, S., Iwakura, Y.
- Publisher
  Springer Science + Buisiness(in press)
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Dermal Vγ6+ γδ T17 Cells Are Involved in Skin Pressure Ulcers in Mice2022
- Author(s)
  Mine Keiichiro、Tun Xin、Hatano Shinya、Noguchi Naoto、Iwakura Yoichiro、Sawa Shinichiro、Nagafuchi Seiho、Yoshikai Yasunobu
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 1 Issue: 8 Pages: 1-10
- DOI
  10.1016/j.jid.2021.12.030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394
[Journal Article] An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity2022
- Author(s)
  Borriello Francesco、Poli Valentina、Shrock Ellen、Spreafico Roberto、Liu Xin、Pishesha Novalia、Carpenet Claire、Chou Janet、Di Gioia Marco、McGrath Marisa E.、Dillen Carly A.、Barrett Nora A.、Lacanfora Lucrezia、Franco Marcella E.、Marongiu Laura、Iwakura Yoichiro、Pucci Ferdinando、Kruppa Michael D.、et al
- Journal Title
  
  Cell
  
  Volume: 185 Issue: 4 Pages: 614-629.e21
- DOI
  10.1016/j.cell.2022.01.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394
[Journal Article] Heat-Killed Levilactobacillus brevis as a Candidate Postbiotics Through Immunostimulation Mediated by Macrophage-Inducible C-Type Lectin2022
- Author(s)
  Shimazu Tomoyuki、Suzuki Mai、Takasaki Ryo、Besshi Asuka、Suzuki Yuna、Iwakura Yoichiro
- Journal Title
  
  Probiotics and Antimicrobial Proteins
  
  Volume: 1 Issue: 3 Pages: 1-10
- DOI
  10.1007/s12602-021-09890-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394
[Journal Article] The C-type lectin receptor Clec1A plays an important role in the development of experimental autoimmune encephalomyelitis by enhancing antigen presenting ability of dendritic cells and inducing inflammatory cytokine IL-172022
- Author(s)
  MAKUSHEVA Yulia、CHUNG Soo-Hyun、AKITSU Aoi、MAEDA Natsumi、MARUHASHI Takumi、YE Xiao-Qi、KAIFU Tomonori、SAIJO Shinobu、SUN Haiyang、HAN Wei、TANG Ce、IWAKURA Yoichiro
- Journal Title
  
  Exp. Anim.
  
  Volume: 71 Issue: 3 Pages: 288-304
- DOI
  10.1538/expanim.21-0191
- NAID
  130008158392
- ISSN
  0007-5124, 1341-1357, 1881-7122
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394, KAKENHI-PROJECT-21J01492
[Journal Article] Intestinal commensal microbiota and cytokines regulate Fut2 <sup>+</sup> Paneth cells for gut defense2022
- Author(s)
  Kamioka Mariko、Goto Yoshiyuki、Nakamura Kiminori、Yokoi Yuki、Sugimoto Rina、Ohira Shuya、Kurashima Yosuke、Umemoto Shingo、Sato Shintaro、Kunisawa Jun、Takahashi Yu、Domino Steven E.、Renauld Jean-Christophe、Nakae Susumu、Iwakura Yoichiro、Ernst Peter B.、Ayabe Tokiyoshi、Kiyono Hiroshi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 3 Pages: 1-10
- DOI
  10.1073/pnas.2115230119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03702, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02394, KAKENHI-PROJECT-21H02891, KAKENHI-PROJECT-21H02963, KAKENHI-PROJECT-20J11528, KAKENHI-PROJECT-21K15460
[Journal Article] Resolving the Mutually Exclusive Immune Responses of Chitosan with Nanomechanics and Immunological Assays2022
- Author(s)
  Lee S, Byun S, Lee C, Park SH, Rudra D, Iwakura Y, Lee YJ, Im SH, Hwang DS.
- Journal Title
  
  Advanced healthcare materials
  
  Volume: 9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02394
[Journal Article] USP10 Inhibits Aberrant Cytoplasmic Aggregation of TDP-43 by Promoting Stress Granule Clearance2022
- Author(s)
  Takahashi Masahiko、Kitaura Hiroki、Kakita Akiyoshi、Kakihana Taichi、Katsuragi Yoshinori、Onodera Osamu、Iwakura Yuriko、Nawa Hiroyuki、Komatsu Masaaki、Fujii Masahiro
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 42 Issue: 3
- DOI
  10.1128/mcb.00393-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-21H04771, KAKENHI-PROJECT-19H03432, KAKENHI-PROJECT-21H02394, KAKENHI-PROJECT-20K07757, KAKENHI-PROJECT-21K07291
[Journal Article] Innate Lymphoid Cells Are Required to Induce Airway Hyperreactivity in a Murine Neutrophilic Asthma Model2022
- Author(s)
  Jonckheere Anne-Charlotte、Seys Sven F.、Steelant Brecht、Decaesteker Tatjana、Dekoster Kaat、Cremer Jonathan、Dilissen Ellen、Schols Dominique、Iwakura Yoichiro、Vande Velde Greetje、Breynaert Christine、Schrijvers Rik、Vanoirbeek Jeroen、Ceuppens Jan L.、Dupont Lieven J.、Bullens Dominique M. A.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 1-10
- DOI
  10.3389/fimmu.2022.849155
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394
[Journal Article] Derepression of inflammation-related genes link to microglia activation and neural maturation defect in a mouse model of Kleefstra syndrome2021
- Author(s)
  Yamada Ayumi、Hirasawa Takae、Nishimura Kayako、Shimura Chikako、Kogo Naomi、Fukuda Kei、Kato Madoka、Yokomori Masaki、Hayashi Tetsutaro、Umeda Mana、Yoshimura Mika、Iwakura Yoichiro、Nikaido Itoshi、Itohara Shigeyoshi、Shinkai Yoichi
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 7 Pages: 102741-102741
- DOI
  10.1016/j.isci.2021.102741
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05530, KAKENHI-PROJECT-18H03991, KAKENHI-PROJECT-21H02394
[Journal Article] Dual interleukin-17A/F deficiency protects against acute and chronic response to cigarette smoke exposure in mice2021
- Author(s)
  Wada Hiroo、Nakamura Masuo、Inoue Shin-Ichi、Kudo Akihiko、Hanawa Tomoko、Iwakura Yoichiro、Kobayashi Fumie、Kamma Hiroshi、Kamiya Shigeru、Ito Kazuhiro、Barnes Peter J.、Takizawa Hajime
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 1-10
- DOI
  10.1038/s41598-021-90853-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394
[Journal Article] Interleukin-17 family members in health and disease2021
- Author(s)
  Chung Soo-Hyun、Ye Xiao-Qi、Iwakura Yoichiro
- Journal Title
  
  International Immunology
  
  Volume: 33 Issue: 12 Pages: 723-729
- DOI
  10.1093/intimm/dxab075
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394
[Journal Article] Vγ6 + γδ T cells are critical for protection against infection by Escherichia coli in mice2021
- Author(s)
  Tun Xin、Hatano Shinya、Mine Keiichiro、Noguchi Naoto、Iwakura Yoichiro、Sun Xun、Yoshikai Yasunobu
- Journal Title
  
  European Journal of Immunology
  
  Volume: n/a Issue: 8 Pages: 2093-2096
- DOI
  10.1002/eji.202049010
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H04954, KAKENHI-PROJECT-18H02671, KAKENHI-PLANNED-16H06496, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394
[Journal Article] Staphylococcus cohnii is a potentially biotherapeutic skin commensal alleviating skin inflammation2021
- Author(s)
  Ito Y, Sasaki T, Li Y, et al
- Journal Title
  
  Cell Reports
  
  Volume: 35 Issue: 4 Pages: 109052-109052
- DOI
  10.1016/j.celrep.2021.109052
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H04954, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-20H05627, KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-20H00495, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394, KAKENHI-PROJECT-21K08308
[Journal Article] Homeostatic regulation of T follicular helper and antibody response to particle antigens by IL-1Ra of medullary sinus macrophage origin2021
- Author(s)
  Lin Xinwen、Twelkmeyer Trix、Zhu Danming、Zhang Li、Zhao Yang、Zhang Chao、Iwakura Yoichiro、Meng Guangxun、Hua Zhaolin、Yan Bingyu、Liu William J.、Luo Zhongguang、Gong Sitang、Chen Hairong、Li Shuran、Hou Baidong、Tang Hong
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 17 Pages: 1-10
- DOI
  10.1073/pnas.2019798118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H04954, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394
[Journal Article] DCIR and its ligand asialo-biantennary N-glycan regulate DC function and osteoclastogenesis2021
- Author(s)
  Kaifu Tomonori、Yabe Rikio、Maruhashi Takumi、Chung Soo-Hyun、Tateno Hiroaki、Fujikado Noriyuki、Hirabayashi Jun、Iwakura Yoichiro
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 218 Issue: 12 Pages: 1-10
- DOI
  10.1084/jem.20210435
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394
[Journal Article] Role of Dectin-2 in the Phagocytosis of Cryptococcus neoformans by Dendritic Cells2021
- Author(s)
  Kitai Yuki、Sato Ko、Tanno Daiki、Yuan Xiaoliang、Umeki Aya、Kasamatsu Jun、Kanno Emi、Tanno Hiromasa、Hara Hiromitsu、Yamasaki Sho、Saijo Shinobu、Iwakura Yoichiro、Ishii Keiko、Kawakami Kazuyoshi
- Journal Title
  
  Infection and Immunity
  
  Volume: 89 Issue: 10 Pages: 1-10
- DOI
  10.1128/iai.00330-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00505, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394, KAKENHI-PROJECT-21H02965, KAKENHI-PROJECT-21K07063, KAKENHI-PROJECT-21K16314
[Journal Article] Arthritis flares mediated by tissue-resident memory T cells in the joint2021
- Author(s)
  Chang Margaret H.、Levescot Ana?s、Nelson-Maney Nathan、Blaustein Rachel B.、Winden Kellen D.、Morris Allyn、Wactor Alexandra、Balu Spoorthi、Grieshaber-Bouyer Ricardo、Wei Kevin、Henderson Lauren A.、Iwakura Yoichiro、Clark Rachael A.、Rao Deepak A.、Fuhlbrigge Robert C.、Nigrovic Peter A.
- Journal Title
  
  Cell Reports
  
  Volume: 37 Issue: 4 Pages: 109902-109902
- DOI
  10.1016/j.celrep.2021.109902
- Data Source
  KAKENHI-PROJECT-20H03176
[Journal Article] Structural specificities of cell surface β-glucan polysaccharides determine commensal yeast mediated immuno-modulatory activities2021
- Author(s)
  Lee Changhon、Verma Ravi、Byun Seohyun、Jeun Eun-Ji、Kim Gi-Cheon、Lee Suyoung、Kang Hye-Ji、Kim Chan Johng、Sharma Garima、Lahiri Abhishake、Paul Sandip、Kim Kwang Soon、Hwang Dong Soo、Iwakura Yoichiro、Speciale Immacolata、Molinaro Antonio、De Castro Cristina、Rudra Dipayan、Im Sin-Hyeog
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 1-10
- DOI
  10.1038/s41467-021-23929-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394
[Journal Article] Distinct Roles for Dectin-1 and Dectin-2 in Skin Wound Healing and Neutrophilic Inflammatory Responses2021
- Author(s)
  Yamaguchi Kenji、Kanno Emi、Tanno Hiromasa、Sasaki Ayako、Kitai Yuki、Miura Takayuki、Takagi Naoyuki、Shoji Miki、Kasamatsu Jun、Sato Ko、Sato Yuka、Niiyama Momoko、Goto Yuka、Ishii Keiko、Imai Yoshimichi、Saijo Shinobu、Iwakura Yoichiro、Tachi Masahiro、Kawakami Kazuyoshi
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 141 Issue: 1 Pages: 164-176
- DOI
  10.1016/j.jid.2020.04.030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H04954, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-18K09473, KAKENHI-PROJECT-19K19494, KAKENHI-PROJECT-19H03812, KAKENHI-PROJECT-21K07063
[Journal Article] TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens2021
- Author(s)
  Yabe Rikio、Chung Soo-Hyun、Murayama Masanori A.、Kubo Sachiko、Shimizu Kenji、Akahori Yukiko、Maruhashi Takumi、Seno Akimasa、Kaifu Tomonori、Saijo Shinobu、Iwakura Yoichiro
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 94-94
- DOI
  10.1038/s41467-020-20307-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K20681, KAKENHI-PUBLICLY-20H04954, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-19K06465, KAKENHI-PROJECT-17K16229, KAKENHI-PROJECT-21K07063
[Journal Article] The CTRP3-AdipoR2 Axis Regulates the Development of Experimental Autoimmune Encephalomyelitis by Suppressing Th17 Cell Differentiation2021
- Author(s)
  Murayama Masanori A.、Chi Hsi-Hua、Matsuoka Mako、Ono Takahiro、Iwakura Yoichiro
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 607346-607346
- DOI
  10.3389/fimmu.2021.607346
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K20681, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394, KAKENHI-PROJECT-21K06955
[Journal Article] Arthritis flares mediated by tissue-resident memory T cells in the joint.2021
- Author(s)
  Chang, M. H., Levescot, A., Nelson-Maney, N., Blaustein, R. B., Winden, K. D., Morris, A., Wactor, A. Balu, S., Grieshaber-Bouyer, R., Wei, K., Henderson, L. A., Iwakura, Y., Clark, R. A., Rao, D. A., Fuhlbrigge, R. C., and Nigrovic, P. A.
- Journal Title
  
  Cell Rep.
  
  Volume: 37 Pages: 109902-109902
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02394
[Journal Article] Blocking of interleukin-1 suppresses angiotensin II-induced renal injury2021
- Author(s)
  Akita Koji、Isoda Kikuo、Ohtomo Fumie、Isobe Sarasa、Niida Tomiharu、Sato-Okabayashi Yayoi、Sano Motoaki、Shimada Kazunori、Iwakura Yoichiro、Minamino Tohru
- Journal Title
  
  Clinical Science
  
  Volume: 135 Issue: 17 Pages: 2035-2048
- DOI
  10.1042/cs20201406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394, KAKENHI-PROJECT-17K01470, KAKENHI-PROJECT-20K08433
[Journal Article] IL-1β-driven osteoclastogenic Tregs accelerate bone erosion in arthritis2021
- Author(s)
  Levescot Anais、Chang Margaret H.、Schnell Julia、Nelson-Maney Nathan、Yan Jing、Mart?nez-Bonet Marta、Grieshaber-Bouyer Ricardo、Lee Pui Y.、Wei Kevin、Blaustein Rachel B.、Morris Allyn、Wactor Alexandra、Iwakura Yoichiro、Lederer James A.、Rao Deepak A.、Charles Julia F.、Nigrovic Peter A.
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 131 Issue: 18 Pages: 1-10
- DOI
  10.1172/jci141008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394
[Journal Article] Obesity accelerates hair thinning by stem cell-centric converging mechanisms2021
- Author(s)
  Morinaga H, Mohri Y, Grachtchouk M, Asakawa K, Matsumura H, Oshima M, Takayama N, Kato T, Nishimori Y, Sorimachi Y,?Takubo K, Suganami T, Iwama A, Iwakura Y, Dlugosz AA, Nishimura EK.
- Journal Title
  
  Nature
  
  Volume: 595 Issue: 7866 Pages: 266-271
- DOI
  10.1038/s41586-021-03624-x
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21621, KAKENHI-PROJECT-18K15114, KAKENHI-PROJECT-18H02637, KAKENHI-PUBLICLY-20H04944, KAKENHI-PUBLICLY-20H05503, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-20H03447, KAKENHI-PROJECT-21H02394, KAKENHI-PROJECT-21H02957
[Journal Article] Derepression of inflammation-related genes link to microglia activation and neural maturation defect in a mouse model of Kleefstra syndrome2021
- Author(s)
  Yamada Ayumi、Hirasawa Takae、Nishimura Kayako、Shimura Chikako、Kogo Naomi、Fukuda Kei、Kato Madoka、Yokomori Masaki、Hayashi Tetsutaro、Umeda Mana、Yoshimura Mika、Iwakura Yoichiro、Nikaido Itoshi、Itohara Shigeyoshi、Shinkai Yoichi
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 11 Pages: 103253-103253
- DOI
  10.1016/j.isci.2021.103253
- Data Source
  KAKENHI-PROJECT-20H03176
[Journal Article] Ovalbumin-Induced Airway Inflammation Is Ameliorated in Dectin-1?Deficient Mice, in Which Pulmonary Regulatory T Cells Are Expanded through Modification of Intestinal Commensal Bacteria2021
- Author(s)
  Han Wei、Tang Ce、Baba Seiya、Hamada Tomofumi、Shimazu Tomoyuki、Iwakura Yoichiro
- Journal Title
  
  The Journal of Immunology
  
  Volume: 206 Issue: 9 Pages: 1991-2000
- DOI
  10.4049/jimmunol.2001337
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H04954, KAKENHI-PROJECT-18H02671, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394
[Journal Article] A Vaspin-HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease2021
- Author(s)
  Nakatsuka A, Yamaguchi S, Eguchi J, Kakuta S, Iwakura Y, Sugiyama H, Wada J.
- Journal Title
  
  Commun Biol .
  
  Volume: 4 Issue: 1 Pages: 373-373
- DOI
  10.1038/s42003-021-01902-y
- NAID
  120007004153
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08608, KAKENHI-PROJECT-20K08908, KAKENHI-PUBLICLY-20H04954, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-19H03675, KAKENHI-PROJECT-19K17984, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-19K08679
[Journal Article] Effector memory CD4+T cells in mesenteric lymph nodes mediate bone loss in food-allergic enteropathy model mice, creating IL-4 dominance2021
- Author(s)
  Ono-Ohmachi Aiko、Udagawa Nobuyuki、Nakamichi Yuko、Koide Masanori、Nakajima-Adachi Haruyo
- Journal Title
  
  Mucosal Immunology
  
  Volume: 14 Issue: 6 Pages: 1335-1346
- DOI
  10.1038/s41385-021-00434-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22729, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-20H03471, KAKENHI-PROJECT-20H03872, KAKENHI-PROJECT-21H02394, KAKENHI-PROJECT-21H03125, KAKENHI-PROJECT-19K22728, KAKENHI-PROJECT-20K21689, KAKENHI-PROJECT-21K16389, KAKENHI-PROJECT-19KK0234
[Journal Article] Immunomodulatory role of Parkinson’s disease 7 in inflammatory bowel disease2021
- Author(s)
  Lippai Rita、Veres-Szekely Apor、Sziksz Erna、Iwakura Yoichiro、Pap Domonkos、Rokonay R?ka、Szebeni Be?ta、Lotz G?bor、B?res N?ra J.、Cseh ?ron、Szab? Attila J.、Vannay ?d?m
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 1-10
- DOI
  10.1038/s41598-021-93671-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394
[Journal Article] Chlamydia evasion of neutrophil host defense results in NLRP3 dependent myeloid-mediated sterile inflammation through the purinergic P2X7 receptor2021
- Author(s)
  Yang Chunfu、Lei Lei、Collins John W. Marshall、Briones Michael、Ma Li、Sturdevant Gail L.、Su Hua、Kashyap Anuj K.、Dorward David、Bock Kevin W.、Moore Ian N.、Bonner Christine、Chen Chih-Yu、Martens Craig A.、Ricklefs Stacy、Yamamoto Masahiro、Takeda Kiyoshi、Iwakura Yoichiro、McClarty Grant、Caldwell Harlan D.
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 1-10
- DOI
  10.1038/s41467-021-25749-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394
[Journal Article] Dectin-2-mediated initiation of immune responses caused by influenza virus hemagglutinin2021
- Author(s)
  YAMAMOTO Hideki、TOMIYAMA Chikako、SATO Ko、KASAMATSU Jun、TAKANO Kazuki、UMEKI Aya、NAKAHATA Nana、MIYASAKA Tomomitsu、KANNO Emi、TANNO Hiromasa、YAMASAKI Sho、SAIJO Shinobu、IWAKURA Yoichiro、ISHII Keiko、KAWAKAMI Kazuyoshi
- Journal Title
  
  Biomed. Res.
  
  Volume: 42 Issue: 2 Pages: 53-66
- DOI
  10.2220/biomedres.42.53
- NAID
  130008023686
- ISSN
  0388-6107, 1880-313X
- Year and Date
  2021-04-10
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H04954, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-20K17461, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394, KAKENHI-PROJECT-21K07063
[Journal Article] TC10, a Rho family GTPase, is required for efficient axon regeneration in a neuron-autonomous manner.2021
- Author(s)
  Koinuma, S., Negishi, R., Nomura, R., Sato, K., Kojima, T., Segi-Nishida, E., Goitsuka, R., Iwakura, Y., Wada, N., Koriyama, Y., Kiryu-Seo, S., Kiyama, H., and Nakamura, T. J.
- Journal Title
  
  J. Neurochem.
  
  Volume: 157 Pages: 1196-1206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02394
[Journal Article] Influenza virus infection expands the breadth of antibody responses through IL-4 signalling in B cells2021
- Author(s)
  Miyauchi Kosuke、Adachi Yu、Tonouchi Keisuke、Yajima Taiki、Harada Yasuyo、Fukuyama Hidehiro、Deno Senka、Iwakura Yoichiro、Yoshimura Akihiko、Hasegawa Hideki、Yugi Katsuyuki、Fujii Shin-ichiro、Ohara Osamu、Takahashi Yoshimasa、Kubo Masato
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 1-10
- DOI
  10.1038/s41467-021-24090-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394, KAKENHI-PROJECT-20K07545, KAKENHI-PROJECT-21K08192
[Journal Article] IFN-γ and IL-17A regulate intestinal crypt production of CXCL10 in the healthy and inflamed colon2020
- Author(s)
  Walrath Travis、Malizia Robert A.、Zhu Xinjun、Sharp Stephen P.、D'Souza Shanti S.、Lopez-Soler Reynold、Parr Brian、Kartchner Brittany、Lee Edward C.、Stain Steven C.、Iwakura Yoichiro、O'Connor William
- Journal Title
  
  American Journal of Physiology-Gastrointestinal and Liver Physiology
  
  Volume: 318 Issue: 3 Pages: G479-G489
- DOI
  10.1152/ajpgi.00208.2019
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H02671
[Journal Article] Psoriasis-like skin disorder in transgenic mice expressing a RIG-I Singleton?Merten syndrome variant2020
- Author(s)
  Abu Tayeh Ahmed、Funabiki Masahide、Shimizu Shota、Satoh Saya、Sumin Lee、Iwakura Yoichiro、Kato Hiroki、Fujita Takashi
- Journal Title
  
  International Immunology
  
  Volume: 33 Issue: 4 Pages: 211-224
- DOI
  10.1093/intimm/dxaa071
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H04954, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-20H03176
[Journal Article] Interleukin 17A: a Janus-faced regulator of osteoporosis2020
- Author(s)
  Scheffler J. M.、Grahnemo L.、Engdahl C.、Drevinge C.、Gustafsson K. L.、Corciulo C.、Lawenius L.、Iwakura Y.、Sj?gren K.、Lagerquist M. K.、Carlsten H.、Ohlsson C.、Islander U.
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 1-11
- DOI
  10.1038/s41598-020-62562-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H02671
[Journal Article] Context-Dependent IL-1 mRNA-Destabilization by TTP Prevents Dysregulation of Immune Homeostasis Under Steady State Conditions2020
- Author(s)
  Sneezum Lucy、Eislmayr Kevin、Dworak Helene、Sedlyarov Vitaly、Le Heron Anita、Ebner Florian、Fischer Irmgard、Iwakura Yoichiro、Kovarik Pavel
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 11 Pages: 1-16
- DOI
  10.3389/fimmu.2020.01398
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H04954, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-20H03176
[Journal Article] C1q/TNF-related protein 3 regulates chondrogenic cell proliferation via adiponectin receptor 2 (progestin and adipoQ receptor 2)2020
- Author(s)
  MURAYAMA Masanori A.、IWAKURA Yoichiro
- Journal Title
  
  Translational and Regulatory Sciences
  
  Volume: 2 Issue: 1 Pages: 19-23
- DOI
  10.33611/trs.2_19
- NAID
  130007814846
- ISSN
  2434-4974
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K20681, KAKENHI-PUBLICLY-20H04954, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-17K14978
[Journal Article] Production of IL-17A at innate immune phase leads to decreased Th1 immune response and attenuated host defense against infection with Cryptococcus deneoformans2020
- Author(s)
  Sato K, Yamamoto H, Nomura T, Kasamatsu J, Miyasaka T, Tanno D, Matsumoto I, Kagesawa T, Miyahara A, Zong T, Oniyama A, Kawamura K, Yokoyama R, Kitai Y, Ishizuka S, Kanno E, Tanno H, Suda H, Morita M, Yamamoto M, Iwakura Y, Ishii K, Kawakami K
- Journal Title
  
  The Journal of Immunology
  
  Volume: 205 Issue: 3 Pages: 686-698
- DOI
  10.4049/jimmunol.1901238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07341, KAKENHI-PUBLICLY-20H04954, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-18H02851, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-19K17920
[Journal Article] TC10, a Rho family GTPase, is required for efficient axon regeneration in a neuron‐autonomous manner2020
- Author(s)
  Koinuma Shingo、Negishi Ryota、Nomura Riko、Sato Kazuki、Kojima Takuya、Segi‐Nishida Eri、Goitsuka Ryo、Iwakura Yoichiro、Wada Naoyuki、Koriyama Yoshiki、Kiryu‐Seo Sumiko、Kiyama Hiroshi、Nakamura Takeshi
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: - Issue: 4 Pages: 1196-1206
- DOI
  10.1111/jnc.15235
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06880, KAKENHI-PROJECT-20K07090, KAKENHI-PROJECT-20K20320, KAKENHI-PUBLICLY-20H04954, KAKENHI-PROJECT-18H02524, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-19H03395, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-19K11781, KAKENHI-PROJECT-21H04865, KAKENHI-PROJECT-21H02372, KAKENHI-PROJECT-21K19310
[Journal Article] Innate Immune Functions of Astrocytes are Dependent Upon Tumor Necrosis Factor-Alpha2020
- Author(s)
  Rodgers Kyla R.、Lin Yufan、Langan Thomas J.、Iwakura Yoichiro、Chou Richard C.
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 1-15
- DOI
  10.1038/s41598-020-63766-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-18H02671, KAKENHI-PUBLICLY-20H04954, KAKENHI-PROJECT-20H03176
[Journal Article] IL-17A promotes fatty acid uptake through the IL-17A/IL-17RA/p-STAT3/FABP4 axis to fuel ovarian cancer growth in an adipocyte-rich microenvironment2020
- Author(s)
  Chunyan Yu、 Xiulong Niu、Yongrui Du、Yan Chen、Xiaomei Liu、Lingling Xu、 Yoichiro Iwakura、Xiaoxia Ma、Yan Li、Zhi Yao、 Weimin Deng
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 69 Issue: 1 Pages: 115-126
- DOI
  10.1007/s00262-019-02445-2
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H02671
[Journal Article] Dysregulated skin barrier function in Tmem79 mutant mice promotes IL‐17A‐dependent spontaneous skin and lung inflammation2020
- Author(s)
  Saunders Sean P.、Floudas Achilleas、Moran Tara、Byrne Ciara M.、Rooney Michael D.、Fahy Caoimhe M. R.、Geoghegan Joan A.、Iwakura Yoichiro、Fallon Padraic G.、Schwartz Christian
- Journal Title
  
  Allergy
  
  Volume: 75 Issue: 12 Pages: 3216-3227
- DOI
  10.1111/all.14488
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H04954, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-20H03176
[Journal Article] Cutaneous p38 mitogen-activated protein kinase activation triggers psoriatic dermatitis.2019
- Author(s)
  Sakurai K, Dainichi T, Garcet S, Tsuchiya S, Yamamoto Y, Kitoh A, Honda T, Nomura T, Egawa G, Otsuka A, Nakajima S, Matsumoto R, Nakano Y, Otsuka M, Iwakura Y, Grinberg-Bleyer Y, Ghosh S, Sugimoto Y, Guttman-Yassky E, Krueger JG, Kabashima K.
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 144(4) Issue: 4 Pages: 1036-1049
- DOI
  10.1016/j.jaci.2019.06.019
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08748, KAKENHI-PROJECT-19K22503, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05905, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-17H03990, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-17K19655, KAKENHI-PROJECT-15H05790
[Journal Article] IL-1β Plays an Important Role in Pressure Overload-Induced Atrial Fibrillation in Mice2019
- Author(s)
  Matsushita N, Ishida N, Ibi M, Saito M, Takahashi M, Taniguchi S, Iwakura Y, Morino Y, Taira E, Sawa Y, Hirose M
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 42 Issue: 4 Pages: 543-546
- DOI
  10.1248/bpb.b18-00363
- NAID
  130007622152
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2019-04-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-18K06781, KAKENHI-PROJECT-18K08112, KAKENHI-PROJECT-19K11772, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H02671
[Journal Article] arge scale cacium imaging of the cerebellar vermis during sensory stimulus unravels two response’s components that differ in their spatiotemporal properties.2019
- Author(s)
  Byk, H., Huang, G. J., Iwakura, Y., and Yarom, Y.
- Journal Title
  
  Front. Syst. Neurosci.
  
  Volume: 13 Pages: 18-18
- DOI
  10.3389/fnsys.2019.00018
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H02671
[Journal Article] CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment.2019
- Author(s)
  Drummond, R. A., Swamydas, M., Oikonomou, V., Zhai, B., Dambuza, I. M., Schaefer, B. C., Bohrer, A. C., Mayer-Barber, K. D., Lira, S. A., Iwakura, Y., Filler, S. G., Brown, G. D., Hube, B., Naglik, J. R., Hohl, T. M., and Lionakis, M. S.
- Journal Title
  
  Nat Immunol.
  
  Volume: 20 Issue: 5 Pages: 559-570
- DOI
  10.1038/s41590-019-0377-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H02671
[Journal Article] Defect of interferon γ leads to impaired wound healing through prolonged neutrophilic inflammatory response and enhanced MMP-2 activation.2019
- Author(s)
  Kanno E, Tanno H, Masaki A, Sasaki A, Sato N, Goto M, Shisai M, Yamaguchi K, Takagi N, Shoji M, Kitai Y, Sato K, Kasamatsu J, Ishii K, Miyasaka T, Kawakami K, Imai Y, Iwakura Y, Maruyama R, Tachi M, Kawakami K.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 20(22) Issue: 22 Pages: 5657-5657
- DOI
  10.3390/ijms20225657
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17913, KAKENHI-PROJECT-19K19494, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H02671
[Journal Article] Uncoupling the senescence-associated secretory phenotype from cell cycle exit via IL-1 inactivation unveils its pro-tumorigenic role.2019
- Author(s)
  Lau, L., Porciuncula, A., Yu, A., Iwakura, Y., and David, G.
- Journal Title
  
  Mol. Cell Biol.
  
  Volume: 39 Issue: 12 Pages: 18-35
- DOI
  10.1128/mcb.00586-18
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H02671
[Journal Article] Spontaneous atopic dermataitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β.2019
- Author(s)
  Schwartz, C., Moran, T., Saunders, S. P., Kaszlikowska, A., Floudas, A., Bom, J., Nunez, G., Iwakura, Y., O’Neill, L., Irvine, A. D., McKenzie, A. N. J., Ogg, G., Walsh, P. T., Demengeot, J., and Fallon, P. G.
- Journal Title
  
  Allergy
  
  Volume: 74 Issue: 10 Pages: 1920-1933
- DOI
  10.1111/all.13801
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H02671
[Journal Article] CCR8 leads to eosinophil migration and regulates neutrophil migration in murine allergic enteritis.2019
- Author(s)
  Blanco-Perez, F., Kato, Y., Gonzalez-Menendez, I., Laino, J., Ohbayashi, M., Burggraf, M., Krause, M., Kirberg, J., Iwakura, Y., Martella, M., Quintanilla-Martinez, L., Shibata, N., Vieths, S., Scheurer, S., and Toda, M.
- Journal Title
  
  Sci. Rep.
  
  Volume: 9 Issue: 1 Pages: 9608-9608
- DOI
  10.1038/s41598-019-45653-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H02671
[Journal Article] Role of interleukin-17 in a murine community-associated methicillin-resistant Staphylococcus aureus pneumonia model2019
- Author(s)
  Shibue Yasushi、Kimura Soichiro、Kajiwara Chiaki、Iwakura Yoichiro、Yamaguchi Keizo、Tateda Kazuhiro
- Journal Title
  
  Microbes and Infection
  
  Volume: 21 Issue: 1 Pages: 33-39
- DOI
  10.1016/j.micinf.2018.06.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H02671
[Journal Article] Myeloid C-type lectin receptors in skin/mucoepithelial diseases and tumors.2019
- Author(s)
  Tang, C., Makusheva, Y., Sun, H., Han, W., and Iwakura, Y.
- Journal Title
  
  J. Leukoc. Biol.
  
  Volume: 106 Issue: 4 Pages: 903-917
- DOI
  10.1002/jlb.2ri0119-031r
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H02671
[Journal Article] Dectin-1 Contributes to Myocardial Ischemia/Reperfusion Injury by Regulating Macrophage Polarization and Neutrophil Infiltration2019
- Author(s)
  Fan Qin、Tao Rong、Zhang Hang、Xie Hongyang、Lu Lin、Wang Ting、Su Min、Hu Jian、Zhang Qi、Chen Qiujing、Iwakura Yoichiro、Shen Weifeng、Zhang Ruiyan、Yan Xiaoxiang
- Journal Title
  
  Circulation
  
  Volume: 139 Issue: 5 Pages: 663-678
- DOI
  10.1161/circulationaha.118.036044
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-15H05787
[Journal Article] Dectin-2?induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis2019
- Author(s)
  Miyabe Chie、Miyabe Yoshishige、Bricio-Moreno Laura、Lian Jeffrey、Rahimi Rod A.、Miura Noriko N.、Ohno Naohito、Iwakura Yoichiro、Kawakami Tamihiro、Luster Andrew D.
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 129 Issue: 9 Pages: 3610-3624
- DOI
  10.1172/jci123778
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17813, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-17K10259
[Journal Article] AIM2 inflammasome-derived IL-1β induces postoperative ileus in mice.2019
- Author(s)
  Hupa, K. J., Stein, K., Schneider, R., Lysson, M., Schneiker, B., Hornung, V., Latz, E., Iwakura, Y., Kalff, J. C., and Wehner, S.
- Journal Title
  
  Sci. Rep.
  
  Volume: 9 Issue: 1 Pages: 10602-10602
- DOI
  10.1038/s41598-019-46968-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H02671
[Journal Article] Dectin-2-Mediated Signaling Leads to Delayed Skin Wound Healing through Enhanced Neutrophilic Inflammatory Response and Neutrophil Extracellular Trap Formation.2019
- Author(s)
  Miura T, Kawakami K, Kanno E, Tanno H, Tada H, Sato N, Masaki A, Yokoyama R, Kawamura K, Kitai Y, Takagi N, Yamaguchi K, Yamaguchi N, Kyo Y, Ishii K, Imai Y, Saijo S, Iwakura Y, Tachi M.
- Journal Title
  
  J Invest Dermatol
  
  Volume: 139(3) Issue: 3 Pages: 702-711
- DOI
  10.1016/j.jid.2018.10.015
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09473, KAKENHI-PROJECT-18K19437, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-16K11909, KAKENHI-PROJECT-17K19710, KAKENHI-PROJECT-17K17393, KAKENHI-PROJECT-19K10143, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-16K11824
[Journal Article] Epidermal loss of phospholipase Cδ1 attenuates irritant contact dermatitis2019
- Author(s)
  Shiratori K, Kanemaru K, Ogura T, Nakajima A, Sugizaki Y, Fukuyama T, Iwakura Y, Nakamura Y, Fukami K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 511 Issue: 2 Pages: 330-335
- DOI
  10.1016/j.bbrc.2019.02.046
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02575, KAKENHI-PROJECT-19K16080, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-17H04051
[Journal Article] IL-1R2 deficiency suppresses dextran sodium sulfate-induced colitis in mice via regulation of microbiota.2018
- Author(s)
  Yoshida, K., Murayama, M., Shimizu, K., Tang, C., Katagiri, N., Matsuo, K., Fukai F., and Iwakura, Y.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 496 Issue: 3 Pages: 934-940
- DOI
  10.1016/j.bbrc.2018.01.116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-17K14978
[Journal Article] Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing T(reg) cells through modification of the intestinal microbiota.2018
- Author(s)
  Tang C, Kakuta S, Shimizu K, Kadoki M, Kamiya T, Shimazu T, Kubo S, Saijo S, Ishigame H, Nakae S, Iwakura Y.
- Journal Title
  
  Nat Immunol.
  
  Volume: 19 Issue: 7 Pages: 755-765
- DOI
  10.1038/s41590-018-0134-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19437, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H02671
[Journal Article] TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation2018
- Author(s)
  Zhang Cun-Jin、Jiang Meiling、Zhou Hao、Liu Weiwei、Wang Chenhui、Kang Zizhen、Han Bing、Zhang Quanri、Chen Xing、Xiao Jianxin、Fisher Amanda、Kaiser William J.、Murayama Masanori A.、Iwakura Yoichiro、Gao Ji、Carman Julie、Dongre Ashok、Dubyak George、Abbott Derek W.、Shi Fu-Dong、Ransohoff Richard M.、Li Xiaoxia
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 128 Issue: 12 Pages: 5399-5412
- DOI
  10.1172/jci121901
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-17K14978
[Journal Article] A dendritic cell-based systemic vaccine induces long-lived lung-resident memory Th17 cells and ameliorates pulmonary mycosis2018
- Author(s)
  Ueno Keigo、Urai Makoto、Sadamoto Sota、Shinozaki Minoru、Takatsuka Shogo、Abe Masahiro、Otani Yoshiko、Yanagihara Nao、Shimizu Kiminori、Iwakura Yoichiro、Shibuya Kazutoshi、Miyazaki Yoshitsugu、Kinjo Yuki
- Journal Title
  
  Mucosal Immunology
  
  Volume: 12 Issue: 1 Pages: 265-276
- DOI
  10.1038/s41385-018-0094-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K18385, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-16H05349, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-17K10040
[Journal Article] Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion2018
- Author(s)
  Marazioti A, Lilis I, Vreka M, Apostolopoulou H, Kalogeropoulou A, Giopanou I, Giotopoulou GA, Krontira AC, Iliopoulou M, Kanellakis NI, Agalioti T, Giannou AD, Jones-Paris C, Iwakura Y, Kardamakis D, Blackwell TS, Taraviras S, Spella M, Stathopoulos GT.
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 672-672
- DOI
  10.1038/s41467-018-03051-z
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045
[Journal Article] NK Cells Control Tumor-Promoting Function of Neutrophils in Mice2018
- Author(s)
  Ogura K, Sato-Matsushita M, Yamamoto S, Hori T, Sasahara M, Iwakura Y, Saiki I, Tahara H, Hayakawa Y
- Journal Title
  
  Cancer Immunol Res
  
  Volume: 印刷中 Issue: 3 Pages: 348-357
- DOI
  10.1158/2326-6066.cir-17-0204
- NAID
  120006402039
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06398, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-15K08902, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045
[Journal Article] MAIT cells protect against pulmonary Legionella longbeachae infection2018
- Author(s)
  Wang H, D'Souza C, Lim XY, Kostenko L, Pediongco TJ, Eckle SBG, Meehan BS, Shi M, Wang N, Li S, Liu L, Mak JYW, Fairlie DP, Iwakura Y, Gunnersen JM, Stent AW, Godfrey DI, Rossjohn J, Westall GP, Kjer-Nielsen L, Strugnell RA, McCluskey J, Corbett AJ, Hinks TSC, Chen Z.
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 3350-3350
- DOI
  10.1038/s41467-018-05202-8
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-18H02671
[Journal Article] HER2 overexpression triggers an IL-1α pro-inflammatory circuit to drive tumorigenesis and promote chemotherapy resistance.2018
- Author(s)
  Liu, S., Lee, J. S., Jie, C., Park, M. H., Iwakura, Y., Patel, Y., Soni, M., Reisman, D., and Chen, H.
- Journal Title
  
  Cancer Res.
  
  Volume: 78 Pages: 2040-2051
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02671
[Journal Article] HER2 overexpression triggers an IL-1α pro-inflammatory circuit to drive tumorigenesis and promote chemotherapy resistance.2018
- Author(s)
  Liu, S., Lee, J. S., Jie, C., Park, M. H., Iwakura, Y., Patel, Y., Soni, M., Reisman, D., and Chen, H.
- Journal Title
  
  Cancer Res.
  
  Volume: - Issue: 8 Pages: 2040-2051
- DOI
  10.1158/0008-5472.can-17-2761
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045
[Journal Article] IL-36α is involved in hapten-specific T-cell induction, but not local inflammation, during contact hypersensitivity2018
- Author(s)
  Numata Takafumi、Yoshizaki Takamichi、Yamaguchi Sachiko、Shimura Eri、Iwakura Yoichiro、Harada Kazutoshi、Sudo Katsuko、Tsuboi Ryoji、Nakae Susumu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 506 Issue: 3 Pages: 429-436
- DOI
  10.1016/j.bbrc.2018.10.104
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10256, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-18H02847
[Journal Article] Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation.2018
- Author(s)
  Ikenoue T, Terakado Y, Zhu C, Liu X, Ohsugi T, Matsubara D, Fujii T, Kakuta S,Kubo S, Shibata T, Yamaguchi K, Iwakura Y, Furukawa Y.
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 2021-2021
- DOI
  10.1038/s41598-018-19769-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08672, KAKENHI-PROJECT-16K10558, KAKENHI-PROJECT-17K09369, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-26860227, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PUBLICLY-16H01569
[Journal Article] IL-25 enhances Th17 cell-mediated contact dermatitis by promoting IL-1b production by dermal dendritic cells2018
- Author(s)
  Suto H, Nambu A, Morita H, Yamaguchi S, Numata T, Yoshizaki T, Shimura E, Arae K, Asada Y, Motomura K, Kaneko M, Abe T, Matsuda A, Iwakura Y, Okumura K, Saito H, Matsumoto K, Sudo K, Nakae S
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: In press Issue: 5 Pages: 1500-1509
- DOI
  10.1016/j.jaci.2017.12.1007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04866, KAKENHI-PROJECT-16K20333, KAKENHI-PROJECT-18K08395, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H02671
[Journal Article] Increased mTOR cancels out the effect of reduced Xbp-1 on antibody secretion in IL-1α-deficient B cells2018
- Author(s)
  Zhu Gaizhi、Liu Xiaoling、Fang Ying、Zhai Bing、Xu Ruonan、Han Gencheng、Chen Guojiang、Xiao He、Hou Chunmei、Shen Beifen、Li Yan、Iwakura Yoichiro、Wang Liang、Jiang Zhenyu、Ma Ning、Liu Guangchao、Wang Renxi
- Journal Title
  
  Cellular Immunology
  
  Volume: 328 Pages: 9-17
- DOI
  10.1016/j.cellimm.2018.02.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787
[Journal Article] Interleukin-17-producing γδT (γδ17) cells in inflammatory diseases2018
- Author(s)
  Aoi Akitsu, Yoichiro Iwakura
- Journal Title
  
  Immunology
  
  Volume: 155 Issue: 4 Pages: 418-426
- DOI
  10.1111/imm.12993
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-18H02671
[Journal Article] The ATP Transporter VNUT Mediates Induction of Dectin-1-Triggered Candida Nociception.2018
- Author(s)
  Maruyama K, Takayama Y, Sugisawa E, Yamanoi Y, Yokawa T, Kondo T, Ishibashi KI, Sahoo BR, Takemura N, Mori Y, Kanemaru H, Kumagai Y, Martino MM, Yoshioka Y, Nishijo H, Tanaka H, Sasaki A, Ohno N, Iwakura Y, Moriyama Y, Nomura M, Akira S, Tominaga M.
- Journal Title
  
  iScience
  
  Volume: 6 Pages: 306-318
- DOI
  10.1016/j.isci.2018.08.007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09885, KAKENHI-PROJECT-16K19148, KAKENHI-PROJECT-17K15793, KAKENHI-PLANNED-15H05928, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-16H01849, KAKENHI-PROJECT-18H01841, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-18H02970, KAKENHI-PROJECT-17K15725
[Journal Article] Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells.2018
- Author(s)
  Tong, H., Miyake, Y., Mi-Ichi, F., Iwakura, Y., Hara, H. and Yoshida, H.
- Journal Title
  
  PLoS One
  
  Volume: 13 Issue: 3 Pages: 0195119-0195119
- DOI
  10.1371/journal.pone.0195119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08888, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-16K08842, KAKENHI-PROJECT-16K19117, KAKENHI-PUBLICLY-16H01365, KAKENHI-PUBLICLY-18H04675, KAKENHI-PROJECT-18K07087
[Journal Article] A model of TH17-associated ileal hyperplasia that requires both IL-17A and IFNγ to generate self-tolerance and prevent colitis2018
- Author(s)
  Jeschke Jonathan C.、Mayne Christopher G.、Ziegelbauer Jennifer、DeCiantis Christopher L.、Singh Selina、Kumar Suresh N.、Suchi Mariko、Iwakura Yoichiro、Drobyski William R.、Salzman Nita H、Williams Calvin B.
- Journal Title
  
  Mucosal Immunology
  
  Volume: 11 Issue: 4 Pages: 1127-1137
- DOI
  10.1038/s41385-018-0023-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H02671
[Journal Article] IL-36α from Skin-Resident Cells Plays an Important Role in the Pathogenesis of Imiquimod-Induced Psoriasiform Dermatitis by Forming a Local Autoamplification Loop.2018
- Author(s)
  Hashiguchi Y, Yabe R, Chung SH, Murayama MA, Yoshida K, Matsuo K, Kubo S, Saijo S, Nakamura Y, Matsue H, Iwakura Y.
- Journal Title
  
  J Immunol.
  
  Volume: 201 Issue: 1 Pages: 167-182
- DOI
  10.4049/jimmunol.1701157
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19437, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-17K14978
[Journal Article] IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse.2018
- Author(s)
  Oike T, Kanagawa H, Sato Y, Kobayashi T, Nakatsukasa H, Miyamoto K, Nakamura S, Kaneko Y, Kobayashi S, Harato K, Yoshimura A, Iwakura Y, Takeuchi T, Matsumoto M, Nakamura M, Niki Y, Miyamoto T.
- Journal Title
  
  Sci Rep.
  
  Volume: - Issue: 1 Pages: 15783-15783
- DOI
  10.1038/s41598-018-34173-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15198, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-18H02930, KAKENHI-PROJECT-16K10917
[Journal Article] Inhibition of interleukin-1 suppresses angiotensin II-induced aortic inflammation and aneurysm formation.2018
- Author(s)
  Isoda K, Akita K, Kitamura K, Sato-Okabayashi Y, Kadoguchi T, Isobe S, Ohtomo F, Sano M, Shimada K, Iwakura Y, Daida H
- Journal Title
  
  Int J Cardiol
  
  Volume: 270 Pages: 221-227
- DOI
  10.1016/j.ijcard.2018.05.072
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K17935, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-16K09522, KAKENHI-PROJECT-16K16607
[Journal Article] Production of low-molecular weight soluble yeast β-glucan by an acid degradation method2018
- Author(s)
  Ishimoto Yuina、Ishibashi Ken-ichi、Yamanaka Daisuke、Adachi Yoshiyuki、Kanzaki Ken、Iwakura Yoichiro、Ohno Naohito
- Journal Title
  
  International Journal of Biological Macromolecules
  
  Volume: 107 Pages: 2269-2278
- DOI
  10.1016/j.ijbiomac.2017.10.094
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787
[Journal Article] Host defense against oral microbiota by bone-damaging T cells2018
- Author(s)
  Tsukasaki Masayuki、Komatsu Noriko、Nagashima Kazuki、Nitta Takeshi、Pluemsakunthai Warunee、Shukunami Chisa、Iwakura Yoichiro、Nakashima Tomoki、Okamoto Kazuo、Takayanagi Hiroshi
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 701-701
- DOI
  10.1038/s41467-018-03147-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19582, KAKENHI-PROJECT-16H05202, KAKENHI-PROJECT-16H05506, KAKENHI-PROJECT-15H05653, KAKENHI-PROJECT-15F15414, KAKENHI-PROJECT-15J05324, KAKENHI-PROJECT-15H05703, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-16K15252, KAKENHI-PROJECT-26713015
[Journal Article] BAFF inhibition attenuates fibrosis in scleroderma by modulating the regulatory and effector B cell balance2018
- Author(s)
  Matsushita Takashi、Kobayashi Tadahiro、Mizumaki Kie、Kano Miyu、Sawada Tomoyo、Tennichi Momoko、Okamura Ai、Hamaguchi Yasuhito、Iwakura Yoichiro、Hasegawa Minoru、Fujimoto Manabu、Takehara Kazuhiko
- Journal Title
  
  Science Advances
  
  Volume: 4 Issue: 7 Pages: 9944-9944
- DOI
  10.1126/sciadv.aas9944
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-16K10147
[Journal Article] Dectin-2 deficiency modulates Th1 differentiation and improves wound healing after myocardial infarction.2017
- Author(s)
  Yan, X., Zhang, H., Fan, Q., Hu, J., Tao, R., Chen, Q., Iwakura, Y., Shen, W., Lu, L., Zhang, Q., and Zhang, R.
- Journal Title
  
  Circ. Res.
  
  Volume: 120 Issue: 7 Pages: 1116-1129
- DOI
  10.1161/circresaha.116.310260
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787
[Journal Article] Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis2017
- Author(s)
  Maruyama Kenta、Takayama Yasunori、Kondo Takeshi、Ishibashi Ken-ichi、Sahoo Bikash Ranjan、Kanemaru Hisashi、Kumagai Yutaro、Martino Mika?l M.、Tanaka Hiroki、Ohno Naohito、Iwakura Yoichiro、Takemura Naoki、Tominaga Makoto、Akira Shizuo
- Journal Title
  
  Cell Reports
  
  Volume: 19 Issue: 13 Pages: 2730-2742
- DOI
  10.1016/j.celrep.2017.06.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15725, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-15H02501, KAKENHI-PROJECT-15H05686, KAKENHI-PROJECT-16K15665, KAKENHI-PROJECT-16K19148
[Journal Article] Interleukin-17A-deficient mice are highly susceptible to Toxoplasma gondii infection due to excessively induced T. gondii HSP70 and interferon gamma production2017
- Author(s)
  Moroda M, Takamoto M, Iwakura Y, Nakayama J, Aosai F
- Journal Title
  
  Infection and Immunity
  
  Volume: 85 Issue: 12 Pages: 00399-17
- DOI
  10.1128/iai.00399-17
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15255, KAKENHI-PROJECT-15H05787
[Journal Article] Modulation of an innate immune response by soluble yeast β-glucan prepared by a heat degradation method.2017
- Author(s)
  Ishimoto, Y., Ishibashi, K. I., Yamanaka, D., Adachi, Y., Kanzaki, K., Okita, K., Iwakura, Y., and Ohno, N.
- Journal Title
  
  Int. J. Biol. Macromol.
  
  Volume: 104 Pages: 367-376
- DOI
  10.1016/j.ijbiomac.2017.06.036
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787
[Journal Article] Preferentially expanding Vγ1+ γδ T cells are associated with protective immunity against Plasmodium infection in mice.2017
- Author(s)
  Inoue SI, Niikura M, Asahi H, Iwakura Y, Kawakami Y, Kobayashi F.
- Journal Title
  
  Eur J Immunol.
  
  Volume: 47 Issue: 4 Pages: 685-691
- DOI
  10.1002/eji.201646699
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-15K08449, KAKENHI-PROJECT-15K08451, KAKENHI-PROJECT-15K19085
[Journal Article] Dectin-1 Plays an Important Role in House Dust Mite-Induced Allergic Airway Inflammation through the Activation of CD11b+ Dendritic Cells.2017
- Author(s)
  Ito T, Hirose K, Norimoto A, Tamachi T, Yokota M, Saku A, Takatori H, Saijo S, Iwakura Y, Nakajima H.
- Journal Title
  
  J Immunol.
  
  Volume: 198 Issue: 1 Pages: 61-70
- DOI
  10.4049/jimmunol.1502393
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-26293094, KAKENHI-PROJECT-26461184, KAKENHI-PROJECT-16K09573, KAKENHI-PROJECT-16K15271
[Journal Article] Absence of DCIR1 reduces the rate of endotoxemic hepatitis in mice.2017
- Author(s)
  Ishiguro T, Fukawa T, Akaki K, Nagaoka K, Takeda T, Iwakura Y ,Inaba K, Takahara K.
- Journal Title
  
  Eur J Immunol.
  
  Volume: 47 Issue: 4 Pages: 704-712
- DOI
  10.1002/eji.201646814
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-16K08737
[Journal Article] IL-17A contributes to reducing IFN-gamma/IL-4 ratio and persistence of Entamoeba histolytica during intestinal amebiasis2017
- Author(s)
  Deloer, S. Nakamura, R. Kikuchi, M. Moriyasu, T. Kalenda, Y. D. J. Mohammed, E. S. Senba, M. Iwakura, Y. Yoshida, H. Hamano, S.
- Journal Title
  
  Parasitol Int
  
  Volume: 66 Issue: 6 Pages: 817-823
- DOI
  10.1016/j.parint.2017.09.011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08842, KAKENHI-PROJECT-26305013, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-17H04649, KAKENHI-PROJECT-16K19118
[Journal Article] Production of low-molecular weight soluble yeast β-glucans by an acid degradation method.2017
- Author(s)
  Ishimoto, Y., Ishibashi, K. I., Yamanaka, D., Adachi, Y., Kanzaki, K., Iwakura, Y., and Ohno, N.
- Journal Title
  
  Int. J. Biol. Macromol.
  
  Volume: 107 Issue: 3 Pages: 2269-2278
- DOI
  10.1038/mi.2017.86
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-18H02671
[Journal Article] IL-17A promotes neutrophilic inflammation and disturbs acute wound healing in skin.2017
- Author(s)
  Takagi N, Kawakami K, Kanno E, Tanno H, Takeda A, Ishii K, Imai Y, Iwakura Y, Tachi M.
- Journal Title
  
  Dermatol.
  
  Volume: 26 Issue: 2 Pages: 137-144
- DOI
  10.1111/exd.13115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-15H06052, KAKENHI-PROJECT-26462723
[Journal Article] Pre-Transplantation Blockade of TNF-α-Mediated Oxygen Species Accumulation Protects Hematopoietic Stem Cells.2017
- Author(s)
  Ishida T, Suzuki S, Lai CY, Yamazaki S, Kakuta S, Iwakura Y, Nojima M, Takeuchi Y, Higashihara M, Nakauchi H, Otsu M.
- Journal Title
  
  Stem Cells.
  
  Volume: 35 Issue: 4 Pages: 989-1002
- DOI
  10.1002/stem.2524
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-16H02661, KAKENHI-PROJECT-25713037, KAKENHI-PROJECT-15K20949
[Journal Article] Neutralization of either IL-17A or IL-17F is sufficient to inhibit house dust mite induced allergic asthma in mice.2017
- Author(s)
  Chenuet, P., Fauconnier, L., Madouri. F., Marchiol, T., Rouxel, N., Ledru, A., Mauny, P., Lory, R., Uttenhove, C., van Snick. J., Iwakura, Y., di Padova, F., Quesniaux, V., Togbe, D., and Ryffel, B.
- Journal Title
  
  Clin. Sci. (Lond)
  
  Volume: 131 Issue: 20 Pages: 2533-2548
- DOI
  10.1042/cs20171034
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787
[Journal Article] Brain Interleukin-1 Facilitates Learning of a Water Maze Spatial Memory Task in Young Mice.2017
- Author(s)
  Takemiya T, Fumizawa K, Yamagata K, Iwakura Y, Kawakami M.
- Journal Title
  
  Front Behav Neurosci.
  
  Volume: 11 Pages: 202-202
- DOI
  10.3389/fnbeh.2017.00202
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10064, KAKENHI-PROJECT-25293239, KAKENHI-PROJECT-15H05787
[Journal Article] Phospholipase Cδ1 regulates p38 MAPK activity and skin barrier integrity.2017
- Author(s)
  Kaori Kanemaru, Yoshikazu Nakamura, Kengo Totoki, Takatsugu Fukuyama, Madoka Shoji, Hisae Kaneko, Kanako Shiratori, Atsuko Yoneda, Takafumi Inoue, Yoichiro Iwakura, Kenji Kabashima, Kiyoko Fukami
- Journal Title
  
  Cell Death & Differentiation
  
  Volume: in press Issue: 6 Pages: 1079-1090
- DOI
  10.1038/cdd.2017.56
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293071, KAKENHI-PROJECT-26440036, KAKENHI-PROJECT-15K15417, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-17H04051
[Journal Article] Fungal-derived cues promote ocular autoimmunity through a Dectin-2/Card9-mediated mechanism.2017
- Author(s)
  Brown, B. R., Lee, E. J., Snow, P. E., Vance, E. E., Iwakura, Y., Ohno, N., Miura, N., Lin, X., Brown, G. D., Wells, C. A., Smith, J. R., Caspi, R. R., and Rosenzweig, H. L.
- Journal Title
  
  Clin. Exp. Immunol.
  
  Volume: 190 Issue: 3 Pages: 293-303
- DOI
  10.1111/cei.13021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787
[Journal Article] Advanced glycation end products induce brain-derived neurotrophic factor release from human platelets through the Src-family kinase activation2017
- Author(s)
  Furukawa, K. Fuse, I. Iwakura, Y. Sotoyama, H. Hanyu, O. Nawa, H. Sone, H. Takei, N.
- Journal Title
  
  Cardiovascular diabetology
  
  Volume: 16 Issue: 1 Pages: 20-20
- DOI
  10.1186/s12933-017-0505-y
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350885, KAKENHI-PROJECT-16K07053, KAKENHI-PROJECT-15H05787
[Journal Article] IL-17A promotes neutrophilic inflammation and disturbs acute wound healing in skin.2017
- Author(s)
  Takagi N, Kawakami K, Kanno E, Tanno H, Takeda A, Ishii K, Imai Y, Iwakura Y, Tachi M
- Journal Title
  
  Dermatol.
  
  Volume: 26 Pages: 137-144
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05787
[Journal Article] Elevation of pro-inflammatory cytokine levels following anti-resorptive drug treatment is required for osteonecrosis development in infectious osteomyelitis2017
- Author(s)
  Morita M, Iwasaki R, Sato Y, Kobayashi T, Watanabe R, Oike T, Nakamura S, Keneko Y, Miyamoto K, Ishihara K, Iwakura Y, Ishii K, Matsumoto M, Nakamura M, Kawana H, Nakagawa T, Miyamoto T.
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 46322-46322
- DOI
  10.1038/srep46322
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10490, KAKENHI-PROJECT-16K10917, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-15H04963, KAKENHI-PROJECT-15K11023
[Journal Article] Megakaryocytes compensate for Kit insufficiency in murine arthritis.2017
- Author(s)
  Cunin, P., Penke, L. R., Thon, J. N., Monach, P. A., Jones, T., Chang, M. H., Chen, M. M., Melki, I., Lacroix, S., Iwakura, Y., Ware, J., Gurish, M. F., Italiano, J. E., Boilard, E., and Nigrovic, P. A.
- Journal Title
  
  J. Clin. Invest.
  
  Volume: 27 Issue: 5 Pages: 1714-1724
- DOI
  10.1172/jci84598
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787
[Journal Article] The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation.2017
- Author(s)
  Wang, J., Ge, P., Qiang, L., Tian, F., Zhao, D., Chai, Q., Zhu, M., Zhou, R., Meng, G., Iwakura, Y., Gao, G. F., and Liu, C. H.
- Journal Title
  
  Nat. Commun.
  
  Volume: 8 Issue: 8 Pages: 244-244
- DOI
  10.4049/jimmunol.1700655
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787
[Journal Article] Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase.2017
- Author(s)
  Nakamura F, Okada T, Shishikura M, Uetani N, Taniguchi M, Yagi T, Iwakura Y, Ohshima T, Goshima Y, Strittmatter SM.
- Journal Title
  
  J Neurosci
  
  Volume: 37 Issue: 30 Pages: 7125-7139
- DOI
  10.1523/jneurosci.2519-16.2017
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07062, KAKENHI-PROJECT-16K08447, KAKENHI-PROJECT-15H05787
[Journal Article] Macrophage-derived IL-1α promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity.2017
- Author(s)
  Zhang, C., Feng, J., Du, J., Zhuo, Z., Yang, S., Zhang, W., Wang, W., Zhang, S., Iwakura, Y., Meng, G., Fu, Y. X., Hou, B., and Tang, H.
- Journal Title
  
  Cell. Mol. Immunol.
  
  Volume: - Issue: 11 Pages: 973-982
- DOI
  10.1038/cmi.2017.22
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787
[Journal Article] LC3-associated phagocytosis is required for dendritic cell inflammatory cytokine response to gut commensal yeast Saccharomyces cerevisiae.2017
- Author(s)
  Lamprinaki, D., Beasy, G., Zhekova, A., Wittmann, A., James, S., Dicks, J., Iwakura, Y., Saijo, S., Wang, X., Chow, C. W., Roberts, I., Korcsmaros, T., Mayer, U., Wileman, T., and Kawasaki, N.
- Journal Title
  
  Front. Immunol.
  
  Volume: 8 Pages: 1397-1397
- DOI
  10.3389/fimmu.2017.01397
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-16K15271
[Journal Article] An ocular commensal protects from corneal infection by driving an IL-17 response from mucosal γδT cells.2017
- Author(s)
  St Leger, A. J., Desal, J. V., Drummond, R. A., Kugadas, A., Almaghrabi, F., Silver, P., Raychaudhuri, K., Gadjeva, M., Iwakura, Y., Lionakis, M., and Caspi, R. R.
- Journal Title
  
  Immunity
  
  Volume: 47 Issue: 1 Pages: 148-158
- DOI
  10.1016/j.immuni.2017.06.014
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787
[Journal Article] Bone marrow transplantation alters lung antigen-presenting cells to promote Th17 reponse and the development of pneumonitis and fibrosis following gammaherpesvirus infection.2016
- Author(s)
  Zhou, X., Loomis-King, H., Gurczynski, S. J., Wilke, C. A., Konopka, K. E., Ptaschinski, C., Coomes, S. M., Iwakura, Y., van Dyk, L. F., Lukacs, N. W., and Moore, B. B.
- Journal Title
  
  Mucosal Immunol.
  
  Volume: 9 Issue: 3 Pages: 610-620
- DOI
  10.1038/mi.2015.85
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011
[Journal Article] T cell-intrinsic ASC critically prootes Th17-mediated experimental autoimmune encephalomyelitis.2016
- Author(s)
  Martin, B. N. , et al.
- Journal Title
  
  Nat. Immunol.
  
  Volume: 17 Issue: 5 Pages: 583-592
- DOI
  10.1038/ni.3389
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011
[Journal Article] Adiponectin enhances antibacterial activity of hematopoietic cells by suppressing bone marrow inflammation.2016
- Author(s)
  Masamoto Y, Arai S, Sato T, Yoshimi A, Kubota N, Takamoto I, Iwakura Y, Yoshimura A, Kadowaki T, Kurokawa M
- Journal Title
  
  Immunity
  
  Volume: 44 Issue: 6 Pages: 1422-33
- DOI
  10.1016/j.immuni.2016.05.010
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01481, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-25221305, KAKENHI-PROJECT-16K15500, KAKENHI-PROJECT-26000012
[Journal Article] Isolation of joint-infiltrating cells.2016
- Author(s)
  Akitsu A, Iwakura Y.
- Journal Title
  
  Bio-Protocol.
  
  Volume: 6 Issue: 17
- DOI
  10.21769/bioprotoc.1911
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011
[Journal Article] The potential for repositioning antithyroid agents as antiasthma drugs.2016
- Author(s)
  Suzuki S, Ogawa M, Ohta S, Arima K, Nunomura S, Nanri Y, Mitamura Y, Yoshihara T, Nakamura Y, Yamauchi K, Chibana K, Ishii Y, Lee JJ, Aratani Y, Kakuta S, Kubo S, Iwakura Y, Yoshida H, Izuhara K.
- Journal Title
  
  J Allergy Clin Immunol.
  
  Volume: 138 Issue: 5 Pages: 1458-1461
- DOI
  10.1016/j.jaci.2016.04.047
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-16H05343, KAKENHI-PROJECT-25461164, KAKENHI-PROJECT-26450446, KAKENHI-PROJECT-15K09553, KAKENHI-PROJECT-16K08842, KAKENHI-PROJECT-15K15372
[Journal Article] Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy.2016
- Author(s)
  Javed, N., Xue, G., Lu, A., Xing, Y., Iwakura, Y., Xiao, H., Lecoeur, H., Spath, G. F., and Meng, G.
- Journal Title
  
  Cytokine
  
  Volume: 81 Pages: 101-108
- DOI
  10.1016/j.cyto.2016.03.007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011
[Journal Article] Involvement of IL-17A-producing TCR γδ T cells in late protective immunity against pulmonary Mycobacterium tuberculosis infection.2016
- Author(s)
  Umemura M, Okamoto-Yoshida Y, Yahagi A, Touyama S, Nakae S, Iwakura Y, Matsuzaki G.
- Journal Title
  
  Immun Inflamm Dis.
  
  Volume: 4 Issue: 4 Pages: 401-412
- DOI
  10.1002/iid3.121
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-15K08468
[Journal Article] Expression of receptor protein tyrosine phosphatase δ, PTPδ, in mouse central nervous system.2016
- Author(s)
  Shishikura, M., Nakamura, F., Yamashita, N., Uetani, N., Iwakura, Y., and Goshima, Y.
- Journal Title
  
  Brain Res.
  
  Volume: 1642 Pages: 244-254
- DOI
  10.1016/j.brainres.2016.03.030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-16K07062
[Journal Article] Dectin-2-dependent host defense in mice infected with serotype 3 Streptococcus pneumoniae2016
- Author(s)
  Akahori Y, Miyasaka T, Toyama M, Matsumoto I, Miyahara A, Zong T, Ishii K, Kinjo Y, Miyazaki Y, Saijo S, Iwakura Y, Kawakami K.
- Journal Title
  
  BMC Immunol
  
  Volume: 17 Issue: 1 Pages: 1-1
- DOI
  10.1186/s12865-015-0139-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25713038, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-26293094, KAKENHI-PROJECT-16K15271
[Journal Article] Interleukin-17A promotes aortic endothelial cell activation via transcriptionally and post-transcriptionally activating p38 MAPK pathway.2016
- Author(s)
  Mai, J., Nanayakkara, G., Lopez-Pastrana, J., Li, X., Li, Y. F., Wang, X., Song, A., Virtue, A., Shao, Y., Shan, H., Liu, F., Autieri, M. V., Kunapuli, S. P., Iwakura, Y., Jiang, X., Wang, H., Yang, X. F.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 291 Issue: 10 Pages: 4939-4954
- DOI
  10.1074/jbc.m115.690081
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011
[Journal Article] IL-17-producing γδ T cells enhance bone regeneration2016
- Author(s)
  Ono T, et al.
- Journal Title
  
  Nat Commun
  
  Volume: 7 Issue: 1 Pages: 10928-10928
- DOI
  10.1038/ncomms10928
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04747, KAKENHI-PROJECT-15H05653, KAKENHI-PROJECT-14J03013, KAKENHI-PROJECT-25460606, KAKENHI-PROJECT-25670773, KAKENHI-PROJECT-15H05703, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-16H05506
[Journal Article] IL-21 inhibits IL-17A-producing γδ T cell response after infection with Bacillus Calmette-Guerin via induction of apoptosis2016
- Author(s)
  Huang Y., Matsumura Y., Hatano, S., Noguchi N., Murakamia, T., Iwakura Y., Sun X., Oharad N., Yoshikai Y.
- Journal Title
  
  Innate Immun.
  
  Volume: 22 Issue: 8 Pages: 588-597
- DOI
  10.1177/1753425916664125
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06496, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-26293098
[Journal Article] Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells.2016
- Author(s)
  Wittmann A, Lamprinaki D, Bowles KM, Katzenellenbogen E, Knirel YA, Whitfield C, Nishimura T, Matsumoto N, Yamamoto K, Iwakura Y, Saijo S, Kawasaki N.
- Journal Title
  
  J Biol Chem.
  
  Volume: 291 Issue: 34 Pages: 17629-38
- DOI
  10.1074/jbc.m116.741256
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-26293094, KAKENHI-PROJECT-16K15271
[Journal Article] Immune complexes indirectly suppress the generation of Th17 responses in vivo.2016
- Author(s)
  Ciraci, C., Janczy, J. R., Jain, N., Haasken, S., Pecli, E. Silva, C., Benjamim, C. F., Sadler, J. J., Olivier. A. K., Iwakura, Y., Shayakhmetov, D. M., Sutterwala, F. S., and Cassel, S. L.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 3 Pages: e0151252-e0151252
- DOI
  10.1371/journal.pone.0151252
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011
[Journal Article] The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis.2016
- Author(s)
  Kimura Y., Inoue A.., Hangai S.., Saijo S., Negishi H., Nishio J., Yamasaki S., Iwakura Y., Yanai H., Taniguchi T.
- Journal Title
  
  Proc. Natl. Acad. Sci. U S A.
  
  Volume: 113 Issue: 49 Pages: 14097-14102
- DOI
  10.1073/pnas.1617903113
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-16H06747, KAKENHI-PROJECT-26293094, KAKENHI-PROJECT-16K15271
[Journal Article] IL-17A-producing CD30(+) Vδ1 T cells drive inflammation-induced cancer progression.2016
- Author(s)
  Kimura Y, Nagai N, Tsunekawa N, Sato-Matsushita M, Yoshimoto T, Cua DJ, Iwakura Y, Yagita H, Okada F, Tahara H, Saiki I, Irimura T, Hayakawa Y.
- Journal Title
  
  Cancer Sci.
  
  Volume: 107 Issue: 9 Pages: 1206-14
- DOI
  10.1111/cas.13005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-15J11569, KAKENHI-PROJECT-25293011, KAKENHI-PROJECT-26290059, KAKENHI-PROJECT-26430158, KAKENHI-PROJECT-26460472, KAKENHI-PROJECT-15K07947, KAKENHI-PROJECT-15K08433, KAKENHI-PROJECT-15K08902, KAKENHI-PROJECT-26670023
[Journal Article] Phosphoinositide 3-Kinase δ Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity.2016
- Author(s)
  Lee MJ, Yoshimoto E, Saijo S, Iwakura Y, Lin X, Katz HR, Kanaoka Y, Barrett NA.
- Journal Title
  
  J Immunol.
  
  Volume: 197 Issue: 1 Pages: 278-87
- DOI
  10.4049/jimmunol.1502485
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-26293094, KAKENHI-PROJECT-16K15271
[Journal Article] Expression of Concern. Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein-Mediated β-Cell Proliferation in Human Pancreatic Islets.2016
- Author(s)
  Maedler K, Schumann DM, Sauter N, Ellingsgaard H, Bosco D, Baertschiger R, Iwakura Y, Oberholzer J, Wollheim CB, Gauthier BR, Donath MY.
- Journal Title
  
  Diabetes.
  
  Volume: 65 Issue: 8 Pages: 2462-2462
- DOI
  10.2337/db16-ec08a
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011
[Journal Article] IL-1 receptor antagonist inhibits pancreatic cancer growth by abrogating NF-κB activation.2016
- Author(s)
  Zhuang, Z. N., Ju, H. Q., Aguilar, M., Gocho, T., Li, H., Iida, T., Lee, H., Fan, X., Zhou, H., Ling, J., Li, Z., Fu, J., Wu, M., Li, M., Melisi, D., Iwakura, Y., Xu, K., Fleming, J. B., and Chiao, P. J.
- Journal Title
  
  Clin. Cancer Res.
  
  Volume: 22 Issue: 6 Pages: 1432-1444
- DOI
  10.1158/1078-0432.ccr-14-3382
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011
[Journal Article] Two types of IL-17A-producing γδ T cells in protection against pulmonary infection with Klebsiella pneumoniae2016
- Author(s)
  Murakami T., Hatano S., Yamada H., Iwakura Y., Yoshikai Y.
- Journal Title
  
  J. Infect.Dis.
  
  Volume: 214 Issue: 11 Pages: 1752-1761
- DOI
  10.1093/infdis/jiw443
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-16H06496, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-26293098
[Journal Article] Regulation of inflammation by IL-1A and IL-17F modulates non-alcholic fatty liver disease pathogenesis.2016
- Author(s)
  Giles, D. A., Moreno-Fernandez, M. E., Stankiewicz, T. E., Cappelletti, M., Huppert, S. S., Iwakura, Y., Dong, C., Shanmukhappa, S. K., and Divanovic, S.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 2 Pages: e0149783-e0149783
- DOI
  10.1371/journal.pone.0149783
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011
[Journal Article] Interleukin-17A Regulates Renal Sodium Transporters and Renal Injury in Angiotensin II-Induced Hypertension.2016
- Author(s)
  Norlander AE, Saleh MA, Kamat NV, Ko B, Gnecco J, Zhu L, Dale BL, Iwakura Y, Hoover RS, McDonough AA, Madhur MS.
- Journal Title
  
  Hypertension
  
  Volume: 68 Issue: 1 Pages: 167-74
- DOI
  10.1161/hypertensionaha.116.07493
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011
[Journal Article] Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation.2016
- Author(s)
  Kuroda E, Ozasa K, Temizoz B, Ohata K, Koo CX, Kanuma T, Kusakabe T, Kobari S, Horie M, Morimoto Y, Nakajima S, Kabashima K, Ziegler SF, Iwakura Y, Ise W, Kurosaki T, Nagatake T, Kunisawa J, Takemura N, Uematsu S, Hayashi M, Aoshi T, Kobiyama K, Coban C, Ishii KJ.
- Journal Title
  
  Immunity.
  
  Volume: 45(6) Issue: 6 Pages: 1299-1310
- DOI
  10.1016/j.immuni.2016.11.010
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01367, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-26221306, KAKENHI-PROJECT-16H05256, KAKENHI-PROJECT-15K14404, KAKENHI-PROJECT-15K19142, KAKENHI-PROJECT-16K15289, KAKENHI-PROJECT-15H05790, KAKENHI-PROJECT-16K19148
[Journal Article] IL-17A exacerbates cisplatin-based resistance of OVCA via upregulating the expression of ABCG2 and MDR1 through Gli1-mediated Hh signaling.2016
- Author(s)
  Niu X, Liu W, Wang Y, Liu X, Zhang H, Li Z, Li H, Iwakura Y, Deng W.
- Journal Title
  
  Oncotarget
  
  Volume: 印刷中 Issue: 0
- DOI
  10.18632/oncotarget.10655
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Mincle activation and the Syk/Card9 signaling axis are cetral to the development of autoimmune disease of the eye.2016
- Author(s)
  Lee, E. J., Brown, B. R., Vance, E. E., Snow, P. E., Silver, P. B., Heinrichs, D., Lin, X., Iwakura, Y., Wells, C. A., Caspi, R. R., and Rosenzweig, H. L.
- Journal Title
  
  J. Immunol.
  
  Volume: 196 Issue: 7 Pages: 3148-3158
- DOI
  10.4049/jimmunol.1502355
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011
[Journal Article] Mesenteric lymph nodes contribute to proinflammatory Th17-cell generation during inflammation of the samall intestine in mice.2016
- Author(s)
  Kawabe, T., Suzuki, N., Yamaki, S., Sun, S. L., Asao, A., Okuyama, Y., So, T., Iwakura, Y., and Ishii, N.
- Journal Title
  
  Eur. J. Immunol.
  
  Volume: 46 Issue: 5 Pages: 1119-1131
- DOI
  10.1002/eji.201545907
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-15H04640, KAKENHI-PROJECT-15H04742
[Journal Article] Dectin-1 and Dectin-2 promote control of the fungal pathogen Trichophyton rubrum independently of IL-17 and adaptive immunity in experimental deep dermatophytosis2016
- Author(s)
  Fabio Yoshikawa, Rikio Yabe, Yoichiro Iwakura, Sandro Rogerio de Almeida, Shinobu Saijo
- Journal Title
  
  Innate Immunity
  
  Volume: in press Issue: 5 Pages: 316-24
- DOI
  10.1177/1753425916645392
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293094, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-16K15271, KAKENHI-PROJECT-16K19147
[Journal Article] IL-1R Type 2 Suppresses Collagen-Induced Arthritis Inhibiting IL-1 Signal on Macrophages.2015
- Author(s)
  Shimizu K, Nakajima A, Sudo K, Yang L, Mizoroki A, Ikarashi T, Horai R, Kakuta S, Watanabe T, and Iwakura Y.
- Journal Title
  
  J Immunol.
  
  Volume: 194（７） Pages: 3156-68
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Dendritic cell immunoreceptor 1 alters neutrophil responses in the development of experimental colitis.2015
- Author(s)
  Tokieda, S., Komori, M., Ishiguro, Iwakura, Y., Takahara, K.* and Inaba, K.
- Journal Title
  
  BMC Immunol.
  
  Volume: 16 Issue: 1 Pages: 64-64
- DOI
  10.1186/s12865-015-0129-5
- NAID
  120005689211
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460494, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011
[Journal Article] Neutrophils negatively regulate induction of mucosal IgA responses after sublingual immunization.2015
- Author(s)
  Jee, J., Bonnegarde-Bernard, A., Duverger, A., Iwakura, Y., Cormet-Boyaka, E., Martin, T. L., Steiner, H. E., Bachman, R. C., and Boyaka, P. N.
- Journal Title
  
  Mucosal Immunol.
  
  Volume: 8 Issue: 4 Pages: 735-745
- DOI
  10.1038/mi.2014.105
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787
[Journal Article] A cruciall role of RORγt in the development of spontaneous sialadenitis-like Sjogren’s syndrome.2015
- Author(s)
  Iizuka, M., Tsuboi, H., Matsuo, N., Asashima, H., Hirota, T., Kondo, Y., Iwakura, Y., Takahashi, S., Matsumoto, I., Sumida, T.
- Journal Title
  
  J. Immunol.
  
  Volume: 194(1) Pages: 56-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] DCIR in the “osteo-immune” system.2015
- Author(s)
  1.Maruhashi T, Kaifu T, and Iwakura Y
- Journal Title
  
  Oncotarget
  
  Volume: 6 Issue: 33 Pages: 34051-2
- DOI
  10.18632/oncotarget.6043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26430095
[Journal Article] Neutrophils negatively regulate induction of mucosal IgA responses after sublingual immunization.2015
- Author(s)
  Jee, J., Bonnegarde-Bernard, A., Duverger, A., Iwakura, Y., Cormet-Boyaka, E., Martin, T. L., Steiner, H. E., Bachman, R. C., and Boyaka, P. N.
- Journal Title
  
  Mucosal Immunol.,
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Filaggrin deficiency promotes the dissemination of cutaneously inoculated vaccinia virus.2015
- Author(s)
  Oyoshi, M. K., Beaupre;, J., Venturelli, N., Lewis, C. N., Iwakura, Y., Geha, R. S.
- Journal Title
  
  J. Allergy Clin. Immunol.,
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2(+)Vγ6(+)γδ T cells.2015
- Author(s)
  Akitsu A, Ishigame H, Kakuta S, Chung SH, Ikeda S, Shimizu K, Kubo S, Liu Y, Umemura M, Matsuzaki G, Yoshikai Y, Saijo S, Iwakura Y.
- Journal Title
  
  Nat Commun
  
  Volume: 6 Issue: 1 Pages: 7464-7464
- DOI
  10.1038/ncomms8464
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08468, KAKENHI-PROJECT-25293105, KAKENHI-PROJECT-26293094, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011
[Journal Article] IFN-γ induction by neutrophil-derived IL-17A homodimer augments pulmonary antibacterial defense.2015
- Author(s)
  Cai, S., Batra, S., Langohr, I., Iwakura, Y., and Jeyaseelan, S.
- Journal Title
  
  Mucosal Immunol.
  
  Volume: 9 Issue: 3 Pages: 718-729
- DOI
  10.1038/mi.2015.95
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011
[Journal Article] Local IL-17 production exerts a protective role in murine experimental glomerulonephritis.2015
- Author(s)
  Hamour, S., Gan, P. Y., Pepper, R., Florez Barros, F., Wang, H. H., O'Sullivan, K., Iwakura, Y., Cook, T., Pusey, C., Holdsworth, S., and Salama, A.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 8 Pages: e0136238-e0136238
- DOI
  10.1371/journal.pone.0136238
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011
[Journal Article] 1.Inhibition of Dectin-1 signaling ameliorates colitis by inducing Lactobacillus- mediated regulatory T cell expansion in the intestine.2015
- Author(s)
  Ce Tang, Tomonori Kamiya, Yang Liu, Motohiko Kadoki, Shigeru Kakuta, Kenshiro Oshima, Masahira Hattori, Kozue Takeshita, Takanori Kanai, Shinobu Saijo and Yoichiro Iwakura
- Journal Title
  
  Cell Host & Microbe
  
  Volume: 18 Issue: 2 Pages: 183-197
- DOI
  10.1016/j.chom.2015.07.003
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26830058, KAKENHI-PROJECT-26293094, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011
[Journal Article] Exacerbation of experimental autoimmune encephalomyelitis in mice deficient for DCIR, an inhibitory C-type lectin receptor.2015
- Author(s)
  Seno, A., Maruhashi, T., Kaifu, T., Yabe, R., Fujikado, N., Ma, G., Ikarashi, T., Kakuta, S., and *Iwakura, Y.
- Journal Title
  
  Exp. Anim.
  
  Volume: 未定
- NAID
  130005069862
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice.2015
- Author(s)
  Uryu H, Hashimoto D, Kato K, Hayase E, Matsuoka S, Ogasawara R, Takahashi S, Maeda Y, Iwasaki H, Miyamoto T, Saijo S, Iwakura Y, Hill GR, Akashi K, Teshima T.:
- Journal Title
  
  Blood
  
  Volume: 125 Issue: 19 Pages: 3014-23
- DOI
  10.1182/blood-2014-12-615781
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22130002, KAKENHI-PROJECT-25253069, KAKENHI-PROJECT-26461438, KAKENHI-PROJECT-15K15365, KAKENHI-PROJECT-25461424, KAKENHI-PROJECT-26293094, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011
[Journal Article] Exacerbation of experimental autoimmune encephalomyelitis in mice deficient for DCIR, an inhibitory C-type lectin receptor.2015
- Author(s)
  Seno, A., Maruhashi, T., Kaifu, T., Yabe, R., Fujikado, N., Ma, G., Ikarashi, T., Kakuta, S., and Iwakura, Y.
- Journal Title
  
  Exp. Anim.
  
  Volume: 64 Pages: 109-119
- NAID
  130005069862
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Antibiotic-killed Staphyococcus aureus induces detructive arthritis in mice.2015
- Author(s)
  Ali, A., Zhu, X., Kwiecinski, J., Gjertsson, I., Lindholm, C., Iwakura, Y., Wang, X., Lycke, N., Josefsson, E., Pullerits, R., and Jin, T.
- Journal Title
  
  Arthritis Rheumatol.
  
  Volume: 67（1） Pages: 107-116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis.2015
- Author(s)
  Murayama A.M, Kakuta S, Inoue A, Umeda N, Yonezawa T, Maruhashi T, Tateishi K, Ishigame H, Yabe R, Ikeda S, Seno A, Chi H-H, Hashiguchi Y, Kurata R, Tada T, Kubo S, Sato N, Liu Y, Hattori M, Saijo S, Matsushita M, Fujita T, Sumida T, Iwakura Y
- Journal Title
  
  Nature Communications
  
  Volume: 6 Issue: 1 Pages: 1-12
- DOI
  10.1038/ncomms9483
- NAID
  120006986869
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26450448, KAKENHI-PROJECT-26293094, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011
[Journal Article] PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia.2015
- Author(s)
  Nakamura T, Maeda S, Horiguchi K, Maehara T, Aritake K, Choi BI, Iwakura Y, Urade Y, Murata T.
- Journal Title
  
  Nat Commun
  
  Volume: 10;6 Issue: 1 Pages: 7514-7514
- DOI
  10.1038/ncomms8514
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221205, KAKENHI-PROJECT-15J10812, KAKENHI-PROJECT-25460947, KAKENHI-PROJECT-26660225, KAKENHI-PROJECT-25252049, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-26293051
[Journal Article] CD11c+ DCs accelerate the rejection of older cardiac transplants via IL-17A.2015
- Author(s)
  Oberhuber, R., Heinbokel, T., Cetina Biefer, H. R., Boenisch, O., Hock, K., Bronson, R. T., Wilhelm, M. J., Iwakura, Y., Edtinger, K., Uehara, H., Quante, M., Voskuil, F., Krenzien, F., Slegtenhorst, B., Abdi, R., Pratschke, J., Elkhal, A., and Tullius, S. G.
- Journal Title
  
  Circulation
  
  Volume: 132 Issue: 2 Pages: 122-131
- DOI
  10.1161/circulationaha.114.014917
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011
[Journal Article] α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice.2015
- Author(s)
  Uryu H, Hashimoto D, Kato K, Hayase E, Matsuoka S, Ogasawara R, Takahashi S, Maeda Y, Iwasaki H, Miyamoto T, Saijo S, Iwakura Y, Hill GR, Akashi K, Teshima T.
- Journal Title
  
  Blood.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390101
[Journal Article] IL-1 receptor-antagonist (IL-1Ra) knockout mice show anxiety-like behavior by aging2015
- Author(s)
  Wakabayashi et al.
- Journal Title
  
  Neurosci. Lett.
  
  Volume: 599 Pages: 20-25
- DOI
  10.1016/j.neulet.2015.05.019
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K14309, KAKENHI-PROJECT-23220008, KAKENHI-PROJECT-24300139, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011
[Journal Article] NLRP3 deficiency exacerbates hyperoxia-induced lethality through Stat3 signaling independently of interleukin-1β2015
- Author(s)
  Mizushina, Y., Shirasuna, K., Usui, F., Karasawa, T., Kawashima, A., Kimura, H., Kobayashi, M., Komada, T., Inoue, Y., Mato, N., Yamasawa, H., Latz, E., Iwakura, Y., Kasahara, T., Bando, M., Sugiyama, Y., and Takahashi, M.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 290（8） Pages: 5065-5077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Dectin-2 deficiency promotes Th2 response and mucin production in the lungs after pulmonary infection with Cryptococcus neoformans.2015
- Author(s)
  Nakamura, Y., Sato, K., Yamamoto, H., Matsumura, K., Matsumoto, I., Nomura, T., Miyasaka, T., Ishii, K., Kanno, E., Tachi, M., Yamasaki, S., Saijo, S., Iwakura, Y., Kawakami, K.
- Journal Title
  
  Infect. Immun.
  
  Volume: 83(2) Pages: 671-681
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice.2015
- Author(s)
  Uryu H, Hashimoto D, Kato K, Hayase E, Matsuoka S, Ogasawara R, Takahashi S, Maeda Y, Iwasaki H, Miyamoto T, Saijo S, Iwakura Y, Hill GR, Akashi K, Teshima T.
- Journal Title
  
  blood
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293094
[Journal Article] DDCIR is important for bone homeostasis by regulating IFN-γ production in T cells.2015
- Author(s)
  Maruhashi T*, Kaifu T*, Yabe R, Seno A, Chung SH, Fujikado N, and Iwakura Y
- Journal Title
  
  J. Immunol.
  
  Volume: 194 Issue: 12 Pages: 5681-91
- DOI
  10.4049/jimmunol.1500273
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26430095, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011
[Journal Article] Interdependence between interleukin-1 and tumor necrosis factor regulates TNF-dependent control of Mycobacterium tuberculosis infection.2015
- Author(s)
  Di Paolo, N. C., Shafiani, S., Day, T., Papayannoupoulou, T., Russell, D. W., Iwakura, Y., Sherman, D., Urdahl, K., and Shayakhmetov, D. M.
- Journal Title
  
  Immunity
  
  Volume: 43 Issue: 6 Pages: 1125-36
- DOI
  10.1016/j.immuni.2015.11.016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011
[Journal Article] Mouse model for PTPRD associations with WED/RLS and addiction: reduced expansion alters locomotion, sleep behaviors and cocaine-conditioned place preference.2015
- Author(s)
  Drgonova, J., Walther, D., Wang, K. J., Hartstein, G. L., Lochte, B., Troncoso, J., Uetani, N., Iwakura, Y., and Uhl, G. R.
- Journal Title
  
  Mol. Med.
  
  Volume: 21 Issue: 1 Pages: 717-725
- DOI
  10.2119/molmed.2015.00017
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011
[Journal Article] IL-1 Receptor Type 2 Suppresses Collagen-Induced Arthritis by Inhibiting IL-1 Signal on Macrophages.2015
- Author(s)
  Shimizu K, Nakajima A, Sudo K, Liu Y, Mizoroki A, Ikarashi T, Horai R, Kakuta S, Watanabe T, Iwakura Y.
- Journal Title
  
  J Immunol.
  
  Volume: 194(7) Issue: 7 Pages: 3156-3168
- DOI
  10.4049/jimmunol.1402155
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24500488, KAKENHI-PROJECT-26461961, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011
[Journal Article] Dectin-2 deficiency promotes Th2 response and mucin production in the lungs after pulmonary infection with Cryptococcus neoformans.2015
- Author(s)
  Nakamura Y, Sato K, Yamamoto H, Matsumura K, Matsumoto I, Nomura T, Miyasaka T, Ishii K, Kanno E, Tachi M, Yamasaki S, Saijo S, Iwakura Y, Kawakami K.
- Journal Title
  
  Infect Immun.
  
  Volume: 83 Issue: 2 Pages: 671-681
- DOI
  10.1128/iai.02835-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390101, KAKENHI-PLANNED-26110009, KAKENHI-PROJECT-26293094, KAKENHI-PROJECT-26293099, KAKENHI-PROJECT-26670213
[Journal Article] A critical role of Dectin-1 in hypersensitivity pneumonitis2015
- Author(s)
  Higashino-Kameda M, Yabe-Wada T, Matsuba S, Takeda K, Anzawa K, Mochizuki T, Makimura K, Saijo S, Iwakura Y, Toga H, Nakamura A
- Journal Title
  
  Inflamm Res
  
  Volume: 65 Issue: 3 Pages: 235-44
- DOI
  10.1007/s00011-015-0910-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PROJECT-25460601, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-26293094, KAKENHI-PROJECT-16K09703, KAKENHI-PROJECT-16K15271
[Journal Article] CCR8 regulates contact hypersensitivity by restricting cutaneous dendritic cell migration to the draining lymph nodes.2015
- Author(s)
  Yabe, R., Shimizu, K., Shimizu, S., Azechi, S., Choi, B. I., Sudo, K., Kubo, S., Nakae, S., Ishigame, H., Kakuta, S., and Iwakura, Y.
- Journal Title
  
  Int. Immunol.
  
  Volume: 27（４） Pages: 169-181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Stage-specific roles for Cxcr4 signaling in murine hematopoietic stem/progenitor cells in the process of bone marrow repopulation.2014
- Author(s)
  Lai, C. Y., Yamazaki, S., Okabe, M., Suzuki, S., Maeyama, Y., Iimura, Y., Onodera. M., Kakuta, S., Iwakura, Y., Nojima, M., Otsu, M., and Nakauchi, H.
- Journal Title
  
  Stem Cells
  
  Volume: 32(7) Pages: 1929-1942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Dectin-2 regulates the effector phase of house dust mite-elicited pulmonary inflammation independently from its role in sensitization.2014
- Author(s)
  Parsons MW, Li L, Wallace AM, Lee MJ, Katz HR, Fernandez JM, Saijo S, Iwakura Y, Austen KF, Kanaoka Y, Barrett NA.
- Journal Title
  
  J Immunol.
  
  Volume: 192 Issue: 4 Pages: 1361-1371
- DOI
  10.4049/jimmunol.1301809
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390101, KAKENHI-PROJECT-24220011
[Journal Article] Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in vial infection.2014
- Author(s)
  .Jie, Z., Liang, Y., Hou, L., Dong, C., Iwakura, Y., Soong, L., Cong, Y., and Sun, J.
- Journal Title
  
  J. Immunol.
  
  Volume: 192(7) Pages: 3289-3300
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Targeting IL-1b and IL-17A driven inflammation during influenza-induced exacerbations of chronic lung inflammation.2014
- Author(s)
  Sichelstiel, A., Yadava, K., Trompette, A., Salami, O., Iwakura, Y., Nicod, L. P., and Marsland, B. J.
- Journal Title
  
  PLoS One
  
  Volume: 9(2)
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Rag2-deficient IL-1 Receptor Antagonist-deficient Mice Are a Novel Colitis Model in Which Innate Lymphoid Cell-derived IL-17 Is Involved in the Pathogenesis.2014
- Author(s)
  Akitsu A, Kakuta S, Saijo S, Iwakura Y.
- Journal Title
  
  Exp Anim.
  
  Volume: 63 Pages: 235-246
- NAID
  130003391627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293094
[Journal Article] Immune complexes inhibit IL-1 secretion and inflammasome activation.2014
- Author(s)
  Janczy, J. R., Ciraci, C., Haasken, S., Iwakura, Y., Olivier, A. K., Cassel, S. L., and Sutterwala, F. S.
- Journal Title
  
  J. Immunol.,
  
  Volume: 193(10) Pages: 5190-5198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Chemokine receptor CCR8 is required for lipopolysassharide-triggered cytokine production in mouse peritoneal macrophages.2014
- Author(s)
  Oshio, T., Kawashima, R., Kawamura, Y. I., Hagiwara, T., Mizutani, N., Okada, T., Otsubo, T., Inagaki-Ohara, K., Matsukawa, A., Haga, T., Kakuta, S., Iwakura, Y., Hosokawa, S., and Dohi, T.
- Journal Title
  
  PLoS One
  
  Volume: 9(4)
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] NLRP3 regulates neutrophil functions and contributes to hepatic ischemia-reperfusion injury independently of inflammasomes.2014
- Author(s)
  Inoue, Y., Shirasuna, K., Kimura, H., Usui, F., Kawashima, A., Karasawa, T., Tago, K., Dezaki, K., Nishimura, S., Sagara, J., Noda, T., Iwakura, Y., Tsutsui, H., Taniguchi, S., Yanagisawa, K., Yada, T., Yasuda, Y., and Takahashi, M.
- Journal Title
  
  J. Immunol.
  
  Volume: 192(9) Pages: 4342-4351
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Excess IL-1 signaling enhances the development of Th17 cells by downregulating TGF-β-induced Foxp3 expression.2014
- Author(s)
  Ikeda S, Saijo S, Murayama MA, Shimizu K, Akitsu A, Iwakura Y.
- Journal Title
  
  J Immunol.
  
  Volume: 192 Issue: 4 Pages: 1449-1458
- DOI
  10.4049/jimmunol.1300387
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390101, KAKENHI-PROJECT-24220011
[Journal Article] Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses.2014
- Author(s)
  Chiba, S., Ikushima, H., Ueki, H., Yanai, H., Kimura, Y., Hangai, S., Nishio, J., Negishi, H., Tamura, T., Saijo, S., Iwakura, Y., and Taniguchi T.
- Journal Title
  
  Elife
  
  Volume: 3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Dectin-2 promotes house dust mite-induced Th2 and Th17 cell differentiation and allergic airway inflammation in mice.2014
- Author(s)
  Norimoto, A., Hirose, K., Iwata, A., Tamachi, T., Yokota, M., Takahashi, K., Saijo, S., Iwakura, Y., and Nakajima, H.
- Journal Title
  
  Am. J. Respir. Cell Mol. Biol.
  
  Volume: 印刷中 Issue: 2 Pages: 201-9
- DOI
  10.1165/rcmb.2013-0522oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-26461184, KAKENHI-PROJECT-26860598
[Journal Article] Critical role for inflammasome-independent IL-1b production in osteomyelitis.2014
- Author(s)
  Lukens, J. R., Gross, J. M., Calabrese, C., Iwakura, Y., Lamkanfi, M., Vogel, P., and Kanneganti, T. D.
- Journal Title
  
  Proc. Natl. Acad. Sci. U. S. A.
  
  Volume: 111 Issue: 3 Pages: 1066-1071
- DOI
  10.1073/pnas.1318688111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] The role of C-type lectin receptors in host defense against microbial pathogens.2014
- Author(s)
  Yabe, R., Iwakura, Y., and Saijo, S.
- Journal Title
  
  Glycoscinece: Biology and Medicine
  
  Volume: - Pages: 1319-1329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Dectin-2 promotes house dust mite-induced T helper type 2 and type 17 cell differentiation and allergic airway inflammation in mice.2014
- Author(s)
  Norimoto A, Hirose K, Iwata A, Tamachi T, Yokota M, Takahashi K, Saijo S, Iwakura Y, Nakajima H.
- Journal Title
  
  Am J Respir Cell Mol Biol.
  
  Volume: 51(2) Pages: 201-209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Rag2-deficient IL-1 receptor antagonist deficient mice are a novel colitis model in which innate lymphoid cell-derived IL-17 is involved in the pathogenesis.2014
- Author(s)
  Akitsu A., Kakuta S., Saijo S., Iwakura Y.
- Journal Title
  
  Exp. Anim.
  
  Volume: 印刷中
- NAID
  130003391627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Gene targeting study reveals unexpected expression of brain expressed X-linked 2 in endocrine and tissue stem/progenitor cells in mice.2014
- Author(s)
  Ito, K., Yamazaki, S., Yamamoto, R., Tajima, Y., Yanagida, A., Kobayashi, T., Kato-Itoh, M., Kakuta, S., Iwakura, Y., Nakauchi, H., and Kamiya, A.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 289(43) Pages: 29892-29911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Mast cell-derived IL-1β contributes to uric acid crystal-induced acute arthritis in mice.2014
- Author(s)
  Reber, L. L., Marichal, T., Sokolove, J., Starkl, P., Gaudenzio, N., Iwakura, Y., Karasuyama, H., Schwartz, L. B., Robinson, W. H., Tsai, M., and Galli, S. J.
- Journal Title
  
  Arthritis Rheumatol.,
  
  Volume: 66(10) Pages: 2881-2891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Persistent release of IL-1s from skin is associated with systemic cardio-vascular disease. Emaciation and systemic amyloidosis: the potential of anti-IL-1 therapy for systemic inflammatory disease.2014
- Author(s)
  Yamanaka, K., Nakanishim, T., Saito, H., Maruyamam, J., Isoda, K., Yokochi, A., Imanaka-Yoshida, K., Tsuda, K., Kakeda, M., Okamoto, R., Fujita, S., Iwakura, Y., Suzuki, N., Ito, M., Maruyama, K., Gabazza, E. C., Yoshida, T., Shimaoka, M., and Mizutani, H.
- Journal Title
  
  PLoS One
  
  Volume: 9（8）
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Rag2-deficient IL-1 receptor antagonist-deficient mice are a novel colitis model in which innate lymphoid cell-derived IL-17 is involved in the pathogenesis.2014
- Author(s)
  Akitsu, A., Kakuta, S., Saijo, S., and Iwakura, Y.
- Journal Title
  
  Exp. Anim.
  
  Volume: 63(2) Pages: 235-246
- NAID
  130003391627
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Ectopic cerebellar cell migration causes maldevelopment of purkinje cells and abnormal motor behavior in CXCR4 null mice.2014
- Author(s)
  Huang, G. J., Edwards, A., Tsai, C. Y., Lee, Y. S., Peng, L., Era, T., Hirabayashi, Y., Tsai, C. Y., Nishikawa, S., Iwakura, Y., Chen, S. J., and Flint, J.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 2 Pages: e86471-e86471
- DOI
  10.1371/journal.pone.0086471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses.2014
- Author(s)
  Chiba S, Ikushima H, Ueki H, Yanai H, Kimura Y, Hangai S, Nishio J, Negishi H, Tamura T, Saijo S, Iwakura Y, Taniguchi T.
- Journal Title
  
  eLife
  
  Volume: 04177 Pages: 04177-04177
- DOI
  10.7554/elife.04177
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-12J04120, KAKENHI-PROJECT-13J05883, KAKENHI-PROJECT-14F04416, KAKENHI-PROJECT-14J04316, KAKENHI-PROJECT-14J12292, KAKENHI-PLANNED-22114007, KAKENHI-PROJECT-23390101, KAKENHI-PROJECT-24590574, KAKENHI-PROJECT-26293094, KAKENHI-PROJECT-26860316
[Journal Article] Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity.2014
- Author(s)
  Kagoya Y, Yoshimi A, Kataoka K, Nakagawa M, Kumano K, Arai S, Kobayashi H, Saito T, Iwakura Y, Kurokawa M.
- Journal Title
  
  J Clin Invest.
  
  Volume: 124 Issue: 2 Pages: 528-542
- DOI
  10.1172/jci68101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591369, KAKENHI-PROJECT-23689065, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-24249055, KAKENHI-PROJECT-24790964, KAKENHI-PROJECT-25293316, KAKENHI-PROJECT-25462359, KAKENHI-PROJECT-25670445, KAKENHI-PROJECT-26293330, KAKENHI-PROJECT-26461170, KAKENHI-PROJECT-26860474
[Journal Article] The role of C-type lectin receptors in host defense against microbial pathogens.2014
- Author(s)
  Yabe R, Iwakura Y, Saijo S.
- Journal Title
  
  “Glycoscinece: Biology and Medicine”
  
  Volume: 1 Pages: 1-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293094
[Journal Article] Mechanism of pro-tumorigenic effect of BMP-6: Neovascularizatioon involving tumor-associated macrophages and IL-1a.2014
- Author(s)
  Kwon, S. J., Lee, G. T., Lee, J. H., Iwakura, Y., Kim, W. J., and Kim, I. Y.
- Journal Title
  
  Prostate
  
  Volume: 74 Issue: 2 Pages: 121-133
- DOI
  10.1002/pros.22734
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist.2014
- Author(s)
  Kobiyama K, Aoshi T, Narita H, Kuroda E, Hayashi M, Tetsutani K, Koyama S, Mochizuki S, Sakurai K, Katakai Y, Yasutomi Y, Saijo S, Iwakura Y, Akira S, Coban C, Ishii KJ.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 111 Issue: 8 Pages: 3086-3091
- DOI
  10.1073/pnas.1319268111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390101, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-24591145, KAKENHI-PROJECT-25293100, KAKENHI-PROJECT-25670225
[Journal Article] Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis.2014
- Author(s)
  Song, X., Gao, H., Lin, Y., Yao, Y,. Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi Y, Iwakura Y, and Qian Y.
- Journal Title
  
  Immunity
  
  Volume: 40(1) Pages: 140-152
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Inflammasome-independent IL-1b mediates autoinflammatory diseases in Pstpip2-deficient mice.2014
- Author(s)
  Cassel, S. L., Janczy, J. R., Bing, X., Wilson, S. P., Olivier, A. K., Otero, J. E., Iwakura, Y., Shayakhmetov, D. M., Bassuk, A. G., Abu-Amer, Y., Brogden, K. A., Burns, T. L., Sutterwala, F. S., and Ferguson, P. J.
- Journal Title
  
  Proc. Natl. Acad. Sci. U. S. A.
  
  Volume: 111 Issue: 3 Pages: 1072-1077
- DOI
  10.1073/pnas.1318685111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin.2014
- Author(s)
  Natsuaki, Y., Egawa, G., Nakamizo, S., Ono, S., Hanakawa, S., Okada, T., Kusuba, N., Otsuka, A., Kitoh, A., Honda, T., Nakajima, S., Tsuchiya, S., Sugimoto, Y., Ishii, K. J , Tsutsui, H., Yagita, H., Iwakura, Y., Kubo, M., Ng, L. G., Hashimoto, T., Fuentes, J., Guttman-Yassky, E., Miyachi, Y., and Kabashima, K.
- Journal Title
  
  Nat. Immunol.
  
  Volume: 15（11） Pages: 1064-1069
- NAID
  120005477231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Multiple CD11c+ cells collaboratively express IL-1β to modulate stromal vascular endothelial growth factor and lymph node vascular-stromal growth.2014
- Author(s)
  Benahmed, F., Chyou, S., Dasoveanu, D., Chen, J., Kumar, V., Iwakura, Y., and Lu, T. T.
- Journal Title
  
  J. Immunol.
  
  Volume: 192(9) Pages: 4153-4163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Rag2-deficient IL-1 Receptor Antagonist-deficient Mice Are a Novel Colitis Model in Which Innate Lymphoid Cell-derived IL-17 Is Involved in the Pathogenesis.2014
- Author(s)
  Akitsu A, Kakuta S, Saijo S, Iwakura Y.
- Journal Title
  
  Exp Anim.
  
  Volume: 63 Pages: 235-246
- NAID
  130003391627
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23390101
[Journal Article] Cardiac fibroblasts mediate IL-17A-driven inflammatory dilated cardiomyopathy.2014
- Author(s)
  Wu, L., Ong, S., Talor, M. V., Barin, J. G., Baldeviano, G.　C, Kass,D.A., Bedja, D., Zhang, H., Sheikhm, A., Margolick, J. B., Iwakura, Y., Rose, N. R., and Cihakova, D.
- Journal Title
  
  J. Exp. Med.
  
  Volume: 211(7) Pages: 1449-1464
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] An ITAM-Syk-CARD9 signaling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells.2014
- Author(s)
  Yasukawa, S., Miyazaki, Y., Yoshii, C., Nakaya, M., Ozaki, N., Toda, S., Kuroda, E., Ishibashi, K., Yasuda, T., Natsuaki, Y., Mi-Ichi, F., Iizasa, E., Nakahara, T., Yamazaki, M., Kabashima, K., Iwakura, Y., Takai, T., Saito, T., Kurosaki, T., Malissen, B., Ohno, N., Furue, M., Yoshida, H., and Hara, H.
- Journal Title
  
  Nat. Commun.,
  
  Volume: 5 Pages: 3755-3755
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Potential role of myeloid cell/eosinophil-derived IL-17 in LPS-induced endotoxin shock.2014
- Author(s)
  Shimura, E., Shibui, A., Narushima, S., Nambu, A., Yamaguchi, S., Akitsu, A., Leonard, W. J., Iwakura, Y., Matsumoto, K., Suto, H., Okumura, K., Sudo, K., and Nakae, S.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 453(1) Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Involvement of IL-17A-induced hypercontractility of intestinal smooth muscle cells in persistent gut moter dysfunction.2014
- Author(s)
  Akiho, H., Tokita, Y., Nakamura, K., Satoh, K., Nishiyama, M., Tsuchiya, N., Tsuchiya, K., Ohbuchi, K., Iwakura, Y., Ihara, E., Takayanagi, R., and Yamamoto, M.
- Journal Title
  
  PLoS One
  
  Volume: 9(5)
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Exacerbation of experimental autoimmune encephalomyelitis in mice deficient for DCIR, an inhibitory C-type lectin receptor2014
- Author(s)
  Seno A, Maruhashi T, Kaifu T, Yabe R, Fujikado N, Ma G, Ikarashi T, Kakuta S, Iwakura Y
- Journal Title
  
  Experimental Animals
  
  Volume: Epub
- NAID
  130005069862
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26430095
[Journal Article] Interleukin-1 receptor antagonist originating from bone marrow-derived cells and non-bone marrow-derived cells helps to suppress arterial inflammation and reduce neointimal formation after injury.2014
- Author(s)
  Isoda, K., Akita, K., Isobe, S., Niida, T., Adachi, T., Iwakura, Y., and Daida, H.
- Journal Title
  
  J. Atheroscler. Thromb.
  
  Volume: 21（11） Pages: 1208-1218
- NAID
  130004690941
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Multiple CD11c+ cells collaboratively express IL-1b to modulate stromal vascular endothelial growth factor and lymph node vascular-stromal growth.2014
- Author(s)
  Benahmed, F., Chyou, S., Dasoveanu, D., Chen, J., Kumar, V., Iwakura, Y., and Lu, T. T.
- Journal Title
  
  J. Immunol.
  
  Volume: 印刷中 Issue: 9 Pages: 4153-4163
- DOI
  10.4049/jimmunol.1301765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Involvement of Gr-1dull+ cellsin the production of TNF-a and IL-17 and exacerbated systemic inflammatory response caused by lipopolysaccharide.2014
- Author(s)
  Tanno, D., Akahori, Y., Toyama, M., Sato, K., Kudo, D., Abe, Y., Miyasaka, T., Yamamoto, H., Ishii, K., Kanno, E., Maruyama, R., Kushimoto, S., Iwakura, Y., and Kawakami, K.
- Journal Title
  
  Inflammation
  
  Volume: 37 Issue: 1 Pages: 186-195
- DOI
  10.1007/s10753-013-9729-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] IL-17A as an inducer for Th2 immune responses in murine atopic dermatitits models.2014
- Author(s)
  Nakajima, S., Kitoh, A., Egawa, G., Natsuaki, Y., Nakamizo, S., Sagita, Moniaga, C., Otsuka, A., Honda, T., Hanakawa, S., Amano, W., Iwakura, Y., Nakae, S., Kubo, M., Miyachi, Y., and Kabashima, K.
- Journal Title
  
  J. Invest. Dermatol.
  
  Volume: 134(8) Pages: 2122-2130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Cigarette smoke primes the pulmonary environment to IL-1α/CXCR-2-dependent nontypeable haemophilus influenzae-exacerbated neutrophillia in mice.2014
- Author(s)
  Nikota, J. K., Shen, P., Morissette, M. C., Fernandes, K., Roos, A., Chu, D. K., Barra, N. G., Iwakura, Y., Kolbeck, R., Humbles, A. A., and Stampfli, M. R.
- Journal Title
  
  J. Immunol.
  
  Volume: 193(6) Pages: 3134-3145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in vial infection.2014
- Author(s)
  Jie, Z., Liang, Y., Hou, L., Dong, C., Iwakura, Y., Soong, L., Cong, Y., and Sun, J.
- Journal Title
  
  J. Immunol.
  
  Volume: 192 Issue: 7 Pages: 3289-3300
- DOI
  10.4049/jimmunol.1303281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] CTRP3 plays an important role in the development of collagen-induced arthritis in mice.2014
- Author(s)
  Murayama MA, Kakuta S, Maruhashi T, Shimizu K, Seno A, Kubo S, Sato N, Saijo S, Hattori M, Iwakura Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 443 Issue: 1 Pages: 42-48
- DOI
  10.1016/j.bbrc.2013.11.040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390101, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-24500488
[Journal Article] Dectin-2 promotes house dust mite-induced Th2 and Th17 cell differentiation and allergic airway inflammation in mice.2014
- Author(s)
  Norimoto A, Hirose K, Iwata A, Tamachi T, Yokota M, Takahashi K, Saijo S, Iwakura Y, Nakajima H.
- Journal Title
  
  Am J Respir Cell Mol Biol.
  
  Volume: Epub ahead of print
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390101
[Journal Article] Defect of CARD9 leads to impaired accululation of IFN-g-producing memory-phenotype T cells in lungs and increased susceptibility to pulmonary infection with Cryptococcus neoformans.2014
- Author(s)
  Yamamoto, H., Nakamura, Y., Sato, K., Takahashi, Y., Nomura, T., Miyasaka, T., Ishii, K., Hara, H., Yamamoto, N., Kanno, E., Iwakura, Y., and Kawakami, K.
- Journal Title
  
  Infect. Immun.
  
  Volume: 82(4) Pages: 1606-1615
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Obesity-induced gut microbial metabolite prootes liver cancer through senescence secretome.2013
- Author(s)
  Yoshimoto, S., Loo, T. M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., Honda, K., Ishikawa, Y., Hara, E., and Ohtani, N.
- Journal Title
  
  Nature
  
  Volume: 499 Issue: 7488 Pages: 97-101
- DOI
  10.1038/nature13004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] MFGE8 inhibits inflammasome-induced IL-1b production and limits postischemic cerebral injury.2013
- Author(s)
  Deroide, N., Li, X., Lerouet, D., Van Vre, E., Baker, L., Harrison, J., Poittevin, M. Masters, L., Nih, L., Margaill, I., Iwakura, Y., Ryffel, B., Pocard, M., Tedgui, A., Kubis, N., and Mallat, Z.
- Journal Title
  
  J. Clin. Invest.
  
  Volume: 123 Issue: 3 Pages: 1176-1181
- DOI
  10.1172/jci65167
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] The Arf GAP SMAP2 is necessary for organized vesicle budding from the trans-Golgi network and subsequent acrosome formation in spermiogenesis.2013
- Author(s)
  Funaki T, Kon S, Tanabe K, Natsume W, Sato S, Shimizu T, Yoshida N, Wong WF, Ogura A, Ogawa T, Inoue K, Ogonuki N, Miki H, Mochida K, Endoh K, Yomogida K, Fukumoto M, Horai R, Iwakura Y, Ito C, Toshimori K, Watanabe T, Satake M.
- Journal Title
  
  Mol. Biol. Cell
  
  Volume: 24 Issue: 17 Pages: 2633-44
- DOI
  10.1091/mbc.e13-05-0234
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23113721, KAKENHI-PROJECT-23501256, KAKENHI-PROJECT-23770148, KAKENHI-PUBLICLY-24112706, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-24570159, KAKENHI-PROJECT-24592441, KAKENHI-ORGANIZER-25112001, KAKENHI-PROJECT-25293041, KAKENHI-PROJECT-25670087
[Journal Article] Double deficiency in IL-17 and IFN-γ signalling significantly suppresses the development of diabetes in the NOD mouse.2013
- Author(s)
  Kuriya G, Uchida T, Akazawa S, Kobayashi M, Nakamura K, Satoh T, Horie I, Kawasaki E, Yamasaki H, Yu L, Iwakura Y, Sasaki H, Nagayama Y, Kawakami A, Abiru N.
- Journal Title
  
  Diabetologia
  
  Volume: 56 Issue: 8 Pages: 1773-1780
- DOI
  10.1007/s00125-013-2935-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791060, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-24591334
[Journal Article] IL-17A promotes macrophage effector mechanisms against Trypanosoma cruzi by trapping parasites in the endolysosomal compartment.2013
- Author(s)
  Erdmann, H., RoBnagel, C., Bohme, J., Iwakura, Y., Jacobs, T., Schaible, U. E., and Holscher, C.
- Journal Title
  
  Immunobiology
  
  Volume: 218, Issue: 6 Pages: 910-923
- DOI
  10.1016/j.imbio.2012.10.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] IL-17A is essential to the development of elastase-induced pulmonary inflammation and emphysema in mice2013
- Author(s)
  Etsuko Kurimoto
- Journal Title
  
  Respiratory Research
  
  Volume: 14 Issue: 1 Pages: 5-5
- DOI
  10.1186/1465-9921-14-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590526, KAKENHI-PROJECT-22591092, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-25860644
[Journal Article] Transgenic expression of the human LEDGF/p75 gene relieves the species barrier against HIV-1 infection in mouse cells.2013
- Author(s)
  Tada, T., Kadoki, M., Yang, L., Tokunaga, K. and Iwakura, Y.
- Journal Title
  
  Front. Microbiol.
  
  Volume: 4 Pages: 377-377
- DOI
  10.3389/fmicb.2013.00377
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-24790992
[Journal Article] Dectin-2-dependent NKT cell activation and serotype-specific antibody production in mice immunized with pneumococcal polysaccharide vaccine.2013
- Author(s)
  Miyasaka T, Akahori Y, Toyama M, Miyamura N, Ishii K, Saijo S, Iwakura Y, Kinjo Y, Miyazaki Y, Oishi K, Kawakami K.
- Journal Title
  
  PLoS One.
  
  Volume: 8 Issue: 10 Pages: e78611-e78611
- DOI
  10.1371/journal.pone.0078611
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390101, KAKENHI-PROJECT-24220011
[Journal Article] Negative feedback on IL-23 exerted by IL-17A during pulmonary inflammation.2013
- Author(s)
  Silverpil, E., Wright, A. K., Hansson, M., Jirholt, P., Henningsson, L., Smith, M. E., Gordon, S. B., Iwakura, Y., Gjertsson, I., Glader, P., and Linden, A.
- Journal Title
  
  Innate Immun.
  
  Volume: 19 Issue: 5 Pages: 479-492
- DOI
  10.1177/1753425912470470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] IL-23 protection against Plasmodium berghei infection in mice is partially dependent on IL-17 from macrophages2013
- Author(s)
  Ishida H, Imai T, Suzue K, Hirai M, Taniguchi T, Yoshimura A, Iwakura Y, Okada H, Suzuki T, Shimokawa C, and Hisaeda
- Journal Title
  
  Eur. J. Immunol.
  
  Volume: 43 Issue: 10 Pages: 2696-2706
- DOI
  10.1002/eji.201343493
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24117504, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-24590501, KAKENHI-PROJECT-24790399, KAKENHI-PROJECT-25670226
[Journal Article] Chronic follicular bronchiolitis requires antigen-specific regulatory T cell control to prevent fatal disease progression.2013
- Author(s)
  Schmitt, E. G., Haribhai, D., Jeschke, J. C., Co, D. O., Ziegelbauer, J., Yan, K., Iwakura, Y., Mishra, M. K., Simpson, P., Salzman, N. H., and Williams, C. B.
- Journal Title
  
  J. Immunol.
  
  Volume: 191 Issue: 11 Pages: 5460-5476
- DOI
  10.4049/jimmunol.1301576
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Mature Dendritic Cell Suppression by IL- 1 Receptor Antagonist on Retinal Pigment Epithelium Cells2013
- Author(s)
  Sugita S, Kawazoe Y, Imai A, Usui Y, Iwakura Y, Isoda K, Ito M, Mochizuki M
- Journal Title
  
  Invest Ophthalmol Vis Sci.
  
  Volume: 54巻 Issue: 5 Pages: 3240-3249
- DOI
  10.1167/iovs.12-11483
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591957, KAKENHI-PROJECT-24220011
[Journal Article] Generation of a mouse model with down-regulated U50 snoRNA (SNORD50) expression and its organ-specific phenotypic modulation2013
- Author(s)
  Soeno Y, Fujita K, Kudo T, Asagiri M, Kakuta S, Taya Y, Shimazu Y, Sato K, Tanaka-Fujita R, Kubo S, Iwakura Y, Nakamura Y, Mori S, and Aoba T
- Journal Title
  
  PLoS ONE
  
  Volume: 8 Issue: 8 Pages: e72105-e72105
- DOI
  10.1371/journal.pone.0072105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592716, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-24500488, KAKENHI-PROJECT-24592780, KAKENHI-PROJECT-24659822, KAKENHI-PROJECT-24689056, KAKENHI-PROJECT-25462935, KAKENHI-PROJECT-25463154
[Journal Article] Vaspin inhibits apoptosis of endothelial cells as a ligand for cell-surface GRP78/VDAC complex.2013
- Author(s)
  Nakatsuka A
- Journal Title
  
  Cir Res
  
  Volume: 112(5) Issue: 5 Pages: 771-780
- DOI
  10.1161/circresaha.111.300049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249053, KAKENHI-PROJECT-23390241, KAKENHI-PROJECT-23659470, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-24500488, KAKENHI-PROJECT-24790926, KAKENHI-PUBLICLY-23114504, KAKENHI-PUBLICLY-23126516
[Journal Article] C-Type lectin is an FcRr-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor2013
- Author(s)
  Miyake Y, Ynmasaki S, et al.
- Journal Title
  
  Immunity
  
  Volume: 38 Issue: 5 Pages: 1050-62
- DOI
  10.1016/j.immuni.2013.03.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11F01107, KAKENHI-PROJECT-22590875, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-24500488, KAKENHI-PROJECT-24791552, KAKENHI-PROJECT-25461178, KAKENHI-PUBLICLY-23114504
[Journal Article] Colitogenic effector T cells: roles of gut-homing integrin, gut antigen specificity and gd T cells.2013
- Author(s)
  Do, J. S., Visperas, A., Freeman, M. L., Iwakura, Y., Oukka, M., and Min, B.
- Journal Title
  
  Immunol. Cell Biol.
  
  Volume: 92 Issue: 1 Pages: 90-98
- DOI
  10.1038/icb.2013.70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Fatty acid-inudced mitochondrial uncoupling elicits inflammasome-independent IL-1a and sterile vascular inflammation in atherosclerosis.2013
- Author(s)
  Freigang, S., Ampenberger, F., Weiss, A., Kanneganti, T. D., Iwakura, Y., Hersberger, M., and Kopf, M.
- Journal Title
  
  Nat. Immunol.
  
  Volume: 14 Issue: 10 Pages: 1045-1053
- DOI
  10.1038/ni.2704
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Pam3CSK4 enhanced beta cell loss and diabetogenesis: The roles of IFN-gamma and IL-17.2013
- Author(s)
  Al Shamsi, M., Shahin, A., Iwakura, Y., Lukic, M. L., and Mensah-Brown, E. P.
- Journal Title
  
  Clin. Immunol.
  
  Volume: 149 Issue: 1 Pages: 86-96
- DOI
  10.1016/j.clim.2013.06.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Hypoxia enhances innate immune activation to Aspergillus fumigatus through cell wall modulation.2013
- Author(s)
  Shepardson, K. M., Ngo, L. Y., Aimanianda, V., Latge, J.-P., Barker, B. M., Blosser, S. J., Iwakura, Y., Hohl, T. M., and Cramer, R. A.
- Journal Title
  
  Microbe. Infect.
  
  Volume: 15 Issue: 4 Pages: 259-269
- DOI
  10.1016/j.micinf.2012.11.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] IL-17A mediates early post-translpant lesions agter teterotopic trachea allotransplantation in mice.2013
- Author(s)
  Lemaitre, P. H., Vokaer, B., Charbonnier, L. M., Iwakura, Y., Estenne, M., Goldman, M., Leo, O., Remmelink, M., and Le Moine, A.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 7 Pages: e70236-e70236
- DOI
  10.1371/journal.pone.0070236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Regulatory T cells are strong promoters of acute ischemia stroke in mice by inducing dysfunction of the cerebral microvasculature.2013
- Author(s)
  Kleinschnitz, C., Kraft, P., Dreykluft, A., Hagedorn, I., Gobel, K., Schuhmann, M. K., Langhauser, F., Helluy, X., Schwarz, T., Bittner, S., Mayer, C. T., Brede, M., Varallyay. C., Pham, M., Bendszus, M., Jakob, P., Magnus, T., Meuth, S. G., Iwakura, Y., Zernecke, A. et al.
- Journal Title
  
  Blood
  
  Volume: 121 Issue: 4 Pages: 679-691
- DOI
  10.1182/blood-2012-04-426734
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia.2013
- Author(s)
  Kon et al.
- Journal Title
  
  J. Clin. Invest.
  
  Volume: 123 Issue: 3 Pages: 1123-1137
- DOI
  10.1172/jci63711
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501256, KAKENHI-PROJECT-23770137, KAKENHI-PROJECT-23770148, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-24591404, KAKENHI-PROJECT-24659458
[Journal Article] Genetic deletion of IL-17A reduces cigarette smoke-induced inflammation and alveolar type II cell apoptosis.2013
- Author(s)
  Chang, Y., Al-Alwan, L., Audusseau, S., Chouiali, F., Carlevaro-Fita, J., Iwakura, Y., Baglole, C. J., Eidelman, D. H., and Hamid, Q.
- Journal Title
  
  Am. J. Physiol. Lung Cell Mol. Physiol.
  
  Volume: 306 Issue: 2 Pages: L132-L143
- DOI
  10.1152/ajplung.00111.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] RIP1-driven autoinflammation targets IL-1a independently of inflammasomes and RIP3.2013
- Author(s)
  Lukens, J. R., Vogel, P., Johnson, G. R., Kelliher, M. A., Iwakura, Y., Lamkanfi, M., and Kanneganti, T. D.
- Journal Title
  
  Nature
  
  Volume: 498 Issue: 7453 Pages: 224-227
- DOI
  10.1038/nature12174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilliate obesity-associated airway hyperreactivity.2013
- Author(s)
  Kim, H. Y., Lee, H. J., Chang, Y. J., Pichavant, M., Shore, S. A., Fitzgerald, K. A., Iwakura, Y., Israel, E., Bolger, K., Faul, J., Dekruyff, R. H., and Umetsu, D. T.
- Journal Title
  
  Nat. Med.
  
  Volume: 20 Issue: 1 Pages: 54-61
- DOI
  10.1038/nm.3423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Cyclosporine A drives a Th17- and Th2-mediated posttransplant obliterative airway disease.2013
- Author(s)
  Lemaitre, P. H., Vokaer, B., Charbonnier, L. M., Iwakura, Y., Field, K. A., Estenne, M., Goldman, M., Leo, O., Remmelink, M., and Le Moine, A.
- Journal Title
  
  Am. J. Transplant.
  
  Volume: 13 Issue: 3 Pages: 611-620
- DOI
  10.1111/ajt.12067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Interleukin-1b induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis.2013
- Author(s)
  Shigematsu, Y., Niwa, T., Rehnberg, E., Toyoda, T., Yoshida, S., Mori, A., Wakabayashi, M., Iwakura, Y., Ichinose, M., Kim, Y. J., and Ushijima, T.
- Journal Title
  
  Cancer Lett.
  
  Volume: 340 Issue: 1 Pages: 141-147
- DOI
  10.1016/j.canlet.2013.07.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Evaluation of Kampo medicines used to treat rheumatoid arthritis in collagen-induced arthritic and pX transgenic mice.2013
- Author(s)
  Ono, Y., Ogihara, Y., Saijo, S., Iwakura, Y., and Inoue, M.
- Journal Title
  
  Mod. Rheumatol.
  
  Volume: 13 Issue: 1 Pages: 50-56
- DOI
  10.3109/s101650300007
- NAID
  10015486726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] Neutrophils are essential as a source of IL-17 in the effector phase of arthritis.2013
- Author(s)
  Katayama, M., Ohmura, K., Yukawa, N., Terao, C., Hashimoto, M., Yoshifuji, H., Kawabata, D., Fujii, T., Iwakura, Y., and Mimori, T.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 12
- DOI
  10.1371/annotation/5fedb3bf-c9c2-4862-9ad5-23c8ae484ad5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] 遺伝子改変マウスによる疾患発症機構の解析．2013
- Author(s)
  岩倉洋一郎
- Journal Title
  
  感染・炎症・免疫
  
  Volume: 43 Pages: 313-319
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] IL-22+CD4+T細胞による大腸炎誘導と抑制．2013
- Author(s)
  角木基彦、岩倉洋一郎
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 59 Pages: 405-410
- NAID
  40019636556
- Data Source
  KAKENHI-PROJECT-24220011
[Journal Article] IL-1 signaling is dispensable for protective immunity in Leishmania-resistant mice2011
- Author(s)
  Kautz-Neu, K., Kostka, S. L., Dinges, S., Iwakura, Y., Udey, M. C., and Von Stebut, E.
- Journal Title
  
  Exp. Dermatol.
  
  Volume: 20 Pages: 76-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Functional specialization of interleukin-17 family members2011
- Author(s)
  Iwakura, Yoichiro
- Journal Title
  
  Immunity
  
  Volume: 34 Pages: 149-62
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022016
[Journal Article] G. Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation2011
- Author(s)
  Rivera, A., Hohl, T. M., Collins, N., Leiner, I., Gallegos, A., Saijo, S., Coward, J. W., Iwakura, Y., and Pamer, E.
- Journal Title
  
  J. Exp. Med.
  
  Volume: 208 Pages: 369-381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Desmoglein 3-specific CD4+T cells induce pemphigus vulgaris and interface dermatitis in mice2011
- Author(s)
  Takahashi, H., Kouno, M., Nagao, K., Wada, N., Hata, T., Nishimoto, S., Iwakura, Y., Yoshimura, A., Yamada, T., Kuwana, M., Fujii, H., Koyasu, S., and Amagai, M.
- Journal Title
  
  J. Clin. Invest.
  
  Volume: 121 Pages: 3677-3688
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Functional specialization of interleukin-17 family members.2011
- Author(s)
  Iwakura, Y.
- Journal Title
  
  Immunity
  
  Volume: 34 Pages: 149-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase2011
- Author(s)
  Yoshida, T., Yasumura, M., Uemura, T., Lee, S. J., Ra, M., Taguchi, R., Iwakura, Y., and Mishina, M.
- Journal Title
  
  J. Neurosci.
  
  Volume: 31 Pages: 13485-13499
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Control of T(H) 17 cells occurs in the small intestine2011
- Author(s)
  Esplugues, E., Huber, S., Gagliani, N., Hauser, A. E., Town, T., Wan, Y. Y., O' Connor, W., Rongvaux, A., Van Rooijen, N., Haberman, A. M., Iwakura, Y., Kuchroo, V. K., Kolls, J. K., Bluestone, J. A., Herold, K. C., and Flavell, R. A.
- Journal Title
  
  Nature
  
  Volume: 475 Pages: 514-518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Dectin-1 and Dectin-2 in innate immunity against fungi2011
- Author(s)
  Saijo, S., and Iwakura, Y.
- Journal Title
  
  Int. Immunol.
  
  Volume: 23 Pages: 467-472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Functional specialization of IL-17 family members2011
- Author(s)
  Iwakura, Y., Ishigame, H., Saijo, S., and Nakae, S.
- Journal Title
  
  Immunity
  
  Volume: 34 Pages: 149-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Local microbleeding facilitates IL-6-and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells2011
- Author(s)
  Murakami, M., Okuyama, Y., Ogura, H., Asano, S., Arima, Y., Tsuruoka, M., Harada, M., Kanamoto, M., Sawa, Y., Iwakura, Y., Takatsu, K., Kamimura, D., and Hirano, T.
- Journal Title
  
  J. Exp. Med.
  
  Volume: 208 Pages: 103-114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] The role of glucocorticoids in pregnancy, parturition, lactation, and nurturing in melanocortin receptor 2. deficient mice2011
- Author(s)
  Chida, D., Miyoshi, K., Sato, T., Yoda, T., Kikusui, T., and Iwakura, Y.
- Journal Title
  
  Endocrinology
  
  Volume: 152 Pages: 1652-1660
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Memory/effector(CD45RBlo) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology2011
- Author(s)
  Kamanaka, M., Huber, S., Zenewicz, L. A., Gagliani, N., Rathinam, C., O' Connor, W. Jr., Wan, Y. Y., Nakae, S., Iwakura, Y., Hao, L., and Flavell, R. A.
- Journal Title
  
  J. Exp. Med.
  
  Volume: 208 Pages: 1027-1040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Muramyldipeptide augments the actions of lipopolysacchairde in mice by stimulating macrophages to produe pro-IL-1B and by down-regulation of suppressor of cytokine signaling 1(SOCS1)2011
- Author(s)
  Shikama, Y., Kuroishi, T., Nagai, Y., Iwakura, Y., Shimauchi, H., Takada, H., Sugawara, S., and Endo, Y.
- Journal Title
  
  Innate Immun.
  
  Volume: 17 Pages: 54-59
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Functional recovery after peripheral nerve injury is dependent on the proinflammatory cytokines IL-1. and TNF : implicaitons for neuropathic pain2011
- Author(s)
  Nadeau, S., Filali, M., Zhang, J., Kerr, B. J., Rivest, S., Soulet, D., Iwakura, Y., de Rivero Vaccari, J. P., Keane, R. W., and Lacroix, S.
- Journal Title
  
  J. Neurosci.
  
  Volume: 31 Pages: 12533-12542
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Functional specialization of interleukin-17 family members2011
- Author(s)
  Iwakura, Y.
- Journal Title
  
  Immunity
  
  Volume: 34 Issue: 2 Pages: 149-62
- DOI
  10.1016/j.immuni.2011.02.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390101, KAKENHI-PROJECT-21390303
[Journal Article] M. Type I interferon signaling constrains IL-17A/F secretion byγδT cells during bacterial infection2010
- Author(s)
  Henry, T., Kirimanjeswara, G. S., Ruby, T., Jones, J. W., Peng, K., Perret, M., Ho, L., Sauer, J.-D., Iwakura, Y., Metzger, D. W., and Monack, D.
- Journal Title
  
  J. Immunol.
  
  Volume: 184 Pages: 3755-3767
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung2010
- Author(s)
  Okamoto Yoshida, Y., Umemura, M., Yahagi, A., O' Brien, R. L., Ikuta, K., Kishihara, K., Hara, H., Nakae, S., Iwakura, Y., and Matsuzaki, G.
- Journal Title
  
  J. Immunol.
  
  Volume: 184 Pages: 4414-4422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction.2010
- Author(s)
  Madhur, M.S., Lob, H.E., McCann, L.A., Iwakura, Y., Blinder, Y., Guzik, T.J., Harrison, D.G.
- Journal Title
  
  Hypertension 55
  
  Pages: 500-507
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] IL-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy.2010
- Author(s)
  Baldeviano, G.C., Barin, J.G., Talor, M.V., Srinivasan, S., Bedja, D., Zheng, D., Gabrielson, K., Iwakura, Y., Rose, N.R., Cihakova, D.
- Journal Title
  
  Circulation Res. 106
  
  Pages: 1645-1655
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] IFN-γis a master regulator of endotoxin shock syndrome in mice primed with heat-killed Propionibacterium acnes.2010
- Author(s)
  Kawa, K., Tsutsui, H., Uchiyama, R., Kato, J., Matsui, K., Iwakura, Y., Matsumoto, T., Nakanishi, K.
- Journal Title
  
  Int. Immunol. 22
  
  Pages: 157-166
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Nucleoprotein diet ameliorates arthritis symptoms in mice transgenic for human T-cell leukemia virus type I (HTLV-I).2010
- Author(s)
  Ohtaki, H., Yufu, S., Nakamachi, T., Satoh, K., Shimizu, A., Mori, H., Sato, A., Iwakura, Y., Matsunaga, M., Shioda, S.
- Journal Title
  
  J. Clin. Biochem. Nutr. 46
  
  Pages: 93-104
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] IL-17 is necessary for host protection against acute-phase Trypanosoma cruzi infection2010
- Author(s)
  Miyazaki, Y., Hamano, S., Wang, S., Shimanoe, Y., Iwakura, Y., and Yoshida, H.
- Journal Title
  
  J. Immunol.
  
  Volume: 185 Pages: 1150-1157
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Type I interferon signaling constrains IL-17A/F secretion by gd T cells during bacterial infection.2010
- Author(s)
  Henry, T., Kirimanjeswara, G.S., Ruby, T., Jones, J.W., Peng, K., Perret, M., Ho, L., Sauer, J. -D., Iwakura, Y., Metzger, D.W., Monack, D.M.
- Journal Title
  
  J. Immunol. 184
  
  Pages: 3755-67
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis.2010
- Author(s)
  Teng, M.W.L., Andrews, D.M., McLaughlin, N., von Scheidt, B., Ngiow, S.F., Moller, A., Hill, G.R., Iwakura, Y., Oft, M., Smyth, M.J.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 107
  
  Pages: 8328-33
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] D. Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis2010
- Author(s)
  Chou, R. C., Kim, N. D., Sadik, C. D., Seung, E., Lan, Y., Byrne, M. H., Haribabu, B., Iwakura, Y., and Luster, A.
- Journal Title
  
  Immunity
  
  Volume: 33 Pages: 266-278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Stem cell mobilization with G-CSF induces Type-17 differentiation and promotes scleroderma.2010
- Author(s)
  Hill, G.R., Olver, S.D., Kuns, R.D., Varelias, A., Raffelt, N.C., Don, A.L.J., Markey, K.A., Wilson, Y.A., Smyth, M.J., Iwakura, Y., Tocker, J., Clouston, A., MacDonald, K.P.A.
- Journal Title
  
  Blood 30(Epub ahead of print)
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Lung CD4-CD8-double-negative T cells are prominent producers of IL-17A and IFN-gamma during primary respiratory murine infection with Francisella tularensis live vaccine strain.2010
- Author(s)
  Cowley, S.C., Meierovics, A.I., Frelinger, J.A., Iwakura, Y., Elkins, K.L.
- Journal Title
  
  J. Immunol. 184
  
  Pages: 5791-5801
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] IFN-γregulates the requirement for IL-17 in proteoglycan-induced arthritis.2010
- Author(s)
  Doodes, P.D., Cao, Y., Hamel, K.M., Wang, Y., Rodeghero, R.I., Mikecz, K., Glant T.T., Iwakura, Y., Finnegan, A.
- Journal Title
  
  J. Immunol. 184
  
  Pages: 1552-1559
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death.2010
- Author(s)
  Kono, H., Karmarkar, D., Iwakura, Y., Rock, K.L.
- Journal Title
  
  J. Immunol. 184
  
  Pages: 4470-8
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Dectin-2 recognition ofα-mannans and induction of Th17 differentiation is essential for host defense against Candida albicans2010
- Author(s)
  Saijo, S., Ikeda, S., Yamabe, K., Kakuta, S., Ishigame, H., Akitsu, A., Fujikado, N., Kusaka, T., Kubo, S., Chung, S., Komatsu, R., Miura, N., Adachi, Y., Ohno, N., Shibuya, K., Yamamoto, N., Kawakami, K., Yamasaki, S., Saito, T., Akira, S., and Iwakura,
- Journal Title
  
  Immunity
  
  Volume: 32 Pages: 681-691
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Dectin-2 recognition of α-mannans and induction of Th17 differentiation is essential for host defense against Candida albicans.2010
- Author(s)
  Saijo, S., Ikeda, S., Yamabe, K., Kakuta, S., Ishigame, H., Akitsu, A., Fujikado, N., Kusaka, T., Kubo, S., Chung, S., Komatsu, R., Miura, N., Adachi, Y., Ohno, N., Shibuya, K., Yamamoto, N., Kawakami, K., Yamasaki, S., Saito, T., Akira, S., Iwakura, Y.
- Journal Title
  
  Immunity 32
  
  Pages: 1-11
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Tumor-infiltrating IL-17-producing gammadelta T cells spport the progression of tumor via promoting angiogenesis.2010
- Author(s)
  Wakita, D., Sumida, K., Iwakura, Y., Nishikawa, H., Ohkuri, T., Chamoto, K., Kitamura, H., Nishimura, T.
- Journal Title
  
  Eur. J. Immunol. 15(Epub ahead of print)
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Activation of myeloid dendritic cells by deoxynucleic acids from Cordyceps sinensis via a Toll-like receptor 9-dependent pathway.2010
- Author(s)
  Xiao, G., Miyazato, A., Abe, Y., Zhang, T., Nakamura, K., Inden, K., Tanaka, M., Tanno, D., Miyasaka, T., Ishii, K., Takeda, K., Akira, S., Saijo, S., Iwakura, Y., Adachi, Y., Ohno, N., Yamamoto, N., Kunishima, H., Hirakata, Y., Kaku, M., Kawakami, K.
- Journal Title
  
  Cellular Immunol. 263
  
  Pages: 241-250
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Neural tube defects and impaired neural progenitor cell proliferation in G. 1-deficient mice2010
- Author(s)
  Okae, H., and Iwakura, Y.
- Journal Title
  
  Developmental Dynamics
  
  Volume: 239 Pages: 1089-1101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Th17 cells promote autoimmune anti-myeloperoxidase glomerulomephritits.2010
- Author(s)
  Gan, P.Y., Steinmetz, O.M., Tan, D.S., O'Sullivan, K.M., Ooi, J.D., Iwakura, Y., Kitching, A.R., Holdsworth, S.R.
- Journal Title
  
  J. Am. Soc. Nephrol. 21
  
  Pages: 925-931
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] TNF, but not IL-6 and IL-17, is crucial for the development of T cell-independent psoriasis-like dermatitis in Il1rn^<-/-> mice2010
- Author(s)
  Nakajima, A., Matsuki, T., Komine, M., Asahina, A., Horai, R., Nakae, S., Ishigame, H., Kakuta, S., Saijo, S., and Iwakura, Y.
- Journal Title
  
  J. Immunol.
  
  Volume: 185 Pages: 1887-1893
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] L. Lung CD4-CD8-double-negative T cells are prominent producers of IL-17A and IFN-during primary respiratory murine infection with Francisella tularensis live vaccine strain2010
- Author(s)
  Cowley, S. C., Meierovics, A. I., Frelinger, J. A., Iwakura, Y., and Elkins, K.
- Journal Title
  
  J. Immunol.
  
  Volume: 184 Pages: 5791-5801
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis2010
- Author(s)
  Chung, S. H., Seki, K., Choi, B. I., Kimura, K. B., Ito, A., Fujikado, N., Saijo, S., and Iwakura, Y.
- Journal Title
  
  Arthritis Res. Ther.
  
  Volume: 12 Pages: 188-188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] IL-17 contributes to the development of chronic rejection in a murine-heart transpant model.2010
- Author(s)
  Itoh, S., Nakae, S., Axtell, R.C., Velotta, J.B., Kimura, N., Kajiwara, N., Iwakura, Y., Saito, H., Adachi, H., Steinman, L., Robbins, R.C., Fishbein, M.P.
- Journal Title
  
  J. Clin. Immunol. 30
  
  Pages: 235-40
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors.2010
- Author(s)
  Adamopoulos, I.E., Chao, C.C., Geissler, R., Laface, D., Blumenschein, W., Iwakura, Y., McClanahan, T., Bowman, E.P.
- Journal Title
  
  Arthritis Res. Ther. 12
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] A Th17-polarized cell population that has infiltrated the lung requires cells that convert to IFN-g production in order to induce airway hyperresponsiveness.2010
- Author(s)
  Ashino, S., Wakita, D., Shiohama, Y., Iwakura, Y., Chamoto, K., Ohkuri, T., Kitamura, H., Nishimura, T.
- Journal Title
  
  Int. Immunol. 22
  
  Pages: 503-513
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Deficiency of interleukin-1 receptor antagonist induces aortic valve disease in BALB/c mice.2010
- Author(s)
  Isoda, K., Matsuki, T., Kondo, H., Iwakura, Y., Ohsuzu, F.
- Journal Title
  
  Arterioscler. Thromb. Vasc. Biol. 30
  
  Pages: 708-15
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] IL-1 plays an important role in the bone metabolism under physiological conditions2010
- Author(s)
  Lee, Y.-M., Fujikado, N., Manaka, H., Yasuda, H., and Iwakura, Y.
- Journal Title
  
  Int. Immunol.
  
  Volume: 22 Pages: 805-816
- NAID
  10027907526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] IFN-regulates the requirement for IL-17 in proteoglycan-induced arthritis2010
- Author(s)
  Doodes, P. D., Cao, Y., Hamel, K. M., Wang, Y., Rodeghero, R. I., Mikecz, K., Glant T. T., Iwakura, Y., and Finnegan, A.
- Journal Title
  
  J. Immunol.
  
  Volume: 184 Pages: 1552-1559
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Host-derived Interleukin-1a is important in determining the immunogenicity of 3-Methylcholantrene-tumor cells.2009
- Author(s)
  Elkabets, M., Krelin, Y., Dotan, S., Cerwenka, A., Porgador, A., Lichtenstein, R.G., White, M.R., Zoller, M., Iwakura, Y., Dinarello, C.A., Voronov, E., Apte, R.N.
- Journal Title
  
  J. Immunol. 182
  
  Pages: 4874-4881
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Interleukin-1 deficiency in combination with macrophage depletion increases susceptibility to Pseudomonas aeruginosa bacteremia.2009
- Author(s)
  Horino, T., Matsumoto, T., Ishikawa, H., Kimura, S., Uramatsu, M., Tanabe, M., Tateda, K., Miyazaki, S., Aramaki, Y., Iwakura, Y., Yoshida, M., Onodera, S., Yamaguchi, K.
- Journal Title
  
  Microbiol. Immunol. 53
  
  Pages: 502-511
- NAID
  10027687393
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Characterization of mice deficient in Melanocortin 2 receptor on a B6/Balbc mix background2009
- Author(s)
  Chida, D., Sato, T., Sato, Y., Kubo, M., Yoda, T., Suzuki, H., and Iwakura, Y.
- Journal Title
  
  Mol. Cell. Endocrinol.
  
  Volume: 300 Pages: 32-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Role of T cell TGFβ signaling and IL-17 in allograft acceptance and fibrosis associated with chronic rejection2009
- Author(s)
  Faust, S.M., Lu, G., Marini, B.L., Zou, W., Gordon, D., Iwakura, Y., Laouar, Y., Bishop, D.K.
- Journal Title
  
  J.Immunol. 183
  
  Pages: 7297-7306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] IL-17 is involved in bone resorption in mouse periapical lesions.2009
- Author(s)
  Oseko, F., Yamamoto, T., Akamatsu, Y., Kanamura, N., Iwakura, Y., Imanishi, J., Kita, M.
- Journal Title
  
  Microbiol. Immunol. 53
  
  Pages: 287-294
- NAID
  10027686578
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Pivotal role of cerebral interleukin-17-producingγδT cells in the delayed phase of ischemic brain injury2009
- Author(s)
  Shichita, T., Sugiyama, Y., Ooboshi, H., Sugimori, H., Nakagawa, R., Takada, I., Iwaki, T., Okada, Y., Iida, M., Cua, D. J., Iwakura, Y., and Yoshimura, A.
- Journal Title
  
  Nat. Med.
  
  Volume: 15 Pages: 946-950
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Interleukin(IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-172009
- Author(s)
  Munoz, M., Heimesaat, M. M., Danker, K., Struck, D., Lohmann, U., Plickert, R., Bereswill, S., Fischer, A., Dunay, I. R., Wolk, K., Loddenkemper, C., Krell, H.-W., Libert, C., Lund, L. R., Frey, O., Holscher, C., Iwakura, Y., Ghilardi, N., Ouyang, W., Kamradt, T., Sabat, R., and Liesenfeld, O.
- Journal Title
  
  J. Exp. Med.
  
  Volume: 206 Pages: 3047-3059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Pivotal role of cerebral interleukin-17-producing gdT cells in the delayed phase of ischemic brain injury.2009
- Author(s)
  Shichita, T., Sugiyama, Y., Ooboshi, H., Sugimori, H., Nakagawa, R., Takada, I., Iwaki, T., Okada, Y., Iida, M., Cua, D.J., Iwakura, Y., Yoshimura, A.
- Journal Title
  
  Nat. Med. 15
  
  Pages: 946-950
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] IL-17 promotes progression of cutaneous leishmaniasis in susceptible mice.2009
- Author(s)
  Lopez Kostka, S., Dinges, S., Griewank, K., Iwakura, Y., Udey, M.C., Von Stebut, E.
- Journal Title
  
  J. Immunol. 182
  
  Pages: 3039-3046
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Biotin status affects nickel allergy via regulation of IL-1b production in mice.2009
- Author(s)
  Kuroishi, T., Kinbara, M., Sato, N., Tanaka, Y., Nagai, Y., Iwakura, Y., Endo, Y., Sugawara, S.
- Journal Title
  
  J. Nutrition 139
  
  Pages: 1031-1036
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Toll-like receptor 9-dependent activation of myeloid dendritic cells by deoxynucleic acids from Candida albicans.2009
- Author(s)
  Miyazato A, Nakamura K, Yamamoto N, Mora-Montes HM, Tanaka M, Abe Y, Tanno D, Inden K, Gang X, Ishii K, Takeda K, Akira S, Saijo S, Iwakura Y, Adachi Y, Ohno N, Mitsutake K, Gow NA, Kaku M, Kawakami K.
- Journal Title
  
  Infect. Immun. 77
  
  Pages: 3056-3064
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Role of T cell TGFβsignaling and IL-17 in allograft acceptance and fibrosis associated with chronic rejection.2009
- Author(s)
  Faust, S.M., Lu, G., Marini, B.L., Zou, W., Gordon, D., Iwakura, Y., Laouar, Y., Bishop, D.K.
- Journal Title
  
  J. Immunol. 183
  
  Pages: 7297-7306
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Role of T cell TGFβ signaling and IL-17 in allograft acceptance and fibrosis associated with chronic rejection2009
- Author(s)
  Faust, S.M., Lu, G., Marini, B.L., Zou, W., Gordon, D., Iwakura, Y., Laouar, Y., Bishop, D.K.
- Journal Title
  
  J.Immunol. 183
  
  Pages: 7297-7306
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022016
[Journal Article] Therapeutic effects of interleukin-6 blockade in a murine model of polymyositis that does not require interleukin-17A.2009
- Author(s)
  Okiyama, N., Sugihara, T., Iwakura, Y., Yokozeki, H., Miyasaka, N., Kohsaka, H.
- Journal Title
  
  Arth. Rheum. 60
  
  Pages: 2505-2512
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] E. Pulmonary inflammation triggered by Ricin toxin requires macrophages and IL-1 signaling2009
- Author(s)
  Lindauer, M. L., Wong, J., Iwakura, Y., and Magun, B.
- Journal Title
  
  J. Immunol.
  
  Volume: 183 Pages: 1419-1426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis.2009
- Author(s)
  Oyamada, A., Ikebem H., Itsumi, M., Saiwai, H., Okada, S., Shimoda, K., Iwakura, Y., Nakayama, K.I., Iwamoto, Y., Yoshikai, Y., Yamada, H.
- Journal Title
  
  J. Immunol. 183
  
  Pages: 7539-7546
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Differential roles of IL-17A and IL-17F in host defense against mucoepithelial bacterial infection and allergic responses2009
- Author(s)
  Ishigame, H., Kakuta, S., Nagai, T., Nambu, A., Komiyama, Y., Kadoki, M., Tanahashi, Y., Akitsu, A., Kotaki, H., Sudo, K., Nakae, S., Sasakawa, C., and Iwakura, Y
- Journal Title
  
  Immunity
  
  Volume: 30 Pages: 108-119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Natural occurring IL-17 producing T cells regulagte the initial phase of neutrophil mediated airway responses.2009
- Author(s)
  Tanaka, S., Yoshimoto, T., Naka, T., Nakae, S., Iwakura, Y., Cua, D., Kubo, M.
- Journal Title
  
  J. Immunol. 183
  
  Pages: 7523-7530
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Hepatic platelet accumulation in Fas-mediated hepatitis in mice.2009
- Author(s)
  Ohtaki Y, Yamaguchi K, Yu Z, Kumamoto H, Shimauchi H, Iwakura Y, Sugawara S, Endo Y.
- Journal Title
  
  Int. Immunopharmacol. 9
  
  Pages: 1071-1078
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft versus host disease.2009
- Author(s)
  Yi, T., Chen, Y., Wang, L., Du, G., Huang, D., Zhao, D., Johnstone, H., Young, J., Todorov, I., Umetsu, D.T., Chen, L., Iwakura, Y., Kandeel, F., Forman, S., Zeng, D.
- Journal Title
  
  Blood 114
  
  Pages: 3101-3112
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17.2009
- Author(s)
  Munoz, M., Heimesaat, M. M., Danker, K., Struck, D., Lohmann, U., Plickert, R.,Bereswill, S., Fischer, A., Dunay, I. R., Wolk, K., Loddenkemper, C., Krell, H. -W., Libert, C., Lund, L. R., Frey, O., Holscher, C., Iwakura, Y., Ghilardi, N., Ouyang, W., Kamradt, T., Sabat, R., Liesenfeld, O. Interleukin
- Journal Title
  
  J. Exp. Med. 206
  
  Pages: 3047-3059
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation2009
- Author(s)
  Inoue, A., Setoguchi, K., Matsubara, Y., Okada, K., Sato, N., Iwakura, Y., Higuchi, O., and Yamanashi, Y.
- Journal Title
  
  Science Signaling
  
  Volume: 2 Pages: 7-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] IL-17 promotes progression of cutaneous leishmaniasis in susceptible mice2009
- Author(s)
  Lopez Kostka, S., Dinges, S., Griewank, K., Iwakura, Y., Udey, M. C., and Von Stebut, E.
- Journal Title
  
  J. Immunol.
  
  Volume: 182 Pages: 3039-3046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] A. A protective function for interleukin 17A in T cell-mediated intestinal inflammation2009
- Author(s)
  O' Connor, W. Jr., Kamanaka, M., Booth, C. J., Town, T., Nakae, S., Iwakura, Y., Kolls, J. K., and Flavell, R.
- Journal Title
  
  Nat. Immunol.
  
  Volume: 10 Pages: 603-609
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] A protective function for interleukin 17A in T cell-mediated intestinal inflammation.2009
- Author(s)
  O'Connor, W. Jr., Kamanaka, M., Booth, C.J., Town, T., Nakae, S., Iwakura, Y., Kolls, J.K., Flavell, R.A.
- Journal Title
  
  Nat. Immunol. 10
  
  Pages: 603-609
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] MHC-matched corneal allograft rejection in an IFN-g/IL-17-independent manner in C57BL/6 mice.2009
- Author(s)
  Yamada, J., Hamuro, J., Fukushima, A., Ohteki, T., Terai, K., Iwakura, Y., Yagita, H., Kinoshita, S.
- Journal Title
  
  Invest. Ophthalmol. Vis. Sci. 50
  
  Pages: 2139-2146
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] T helper type 17 immune response plays an indispensable role for development of iodine-induced autoimmune thyroiditis in nonobese diabetic-H2h4 mice.2009
- Author(s)
  Horie, I., Abiru, N., Nagayama, Y., Kuriya, G., Saitoh, O., Ichikawa, T., Iwakura, Y., Eguchi, K.
- Journal Title
  
  Endocrinology 150
  
  Pages: 5135-5142
- NAID
  120006983712
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Muramyldipeptide augments the actions of lipopolysacchairde in mice by stimulating macrophages to produe pro-IL-1b and by down-regulation of suppressor of cytokine signaling 1 (SOCS1).2009
- Author(s)
  Shikama, Y., Kuroishi, T., Nagai, Y., Iwakura, Y., Shimauchi, H., Takada, H., Sugawara, S., Endo, Y.
- Journal Title
  
  Innate Immun. (Epub ahead of print)
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Pulmonary inflammation triggered by Ricin toxin requires macrophages and IL-1 signaling.2009
- Author(s)
  Lindauer, M.L., Wong, J., Iwakura, Y., Magun, B.E.
- Journal Title
  
  J. Immunol. 183
  
  Pages: 1419-1426
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] CXCL12 promotes CCR7-dependent naive T-cell trafficking to lymph nodes and Peyer's patches.2009
- Author(s)
  Bai, Z.B., Hayasaka, H., Kobayashi, M., Li, W., Guo, Z., Jang, M. -H., Kondo, A., Choi, B., Iwakura, Y., Miyasaka, M.
- Journal Title
  
  J. Immunol. 182
  
  Pages: 1287-1295
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Virus binding to a plasma membrane receptor triggers interleukin-1α-mediated proinflammatory macrophage response in vivo.2009
- Author(s)
  Di Paolo, N.C., Miao, E.A., Iwakura, Y., Kaja, M-K., Aderem, A., Flavell, R.A., Papayannopoulou, T., Shayakhmetov, D.M.
- Journal Title
  
  Immunity 31
  
  Pages: 110-121
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Fracisella tularensis.2009
- Author(s)
  Lin, Y., Ritchea, S., Logar, A., Slight, S., Messmer, M., Rangel-Moreno, J., Guglani, L., Alcorn, J. F., Strawbridge, H., Park, S. M., Onishi, R., Nyugen, N., Walter, M. J., Pociask, D., Randall, T. D., Gaffen, S. L., Iwakura, Y., Kolls, J. K., Khader, S. A*.
- Journal Title
  
  Immunity 31
  
  Pages: 799-810
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Differential roles of IL-17A and IL-17F in host defense against mucoepithelial bacterial infection and allergic responses.2009
- Author(s)
  Ishigame, H., Kakuta, S., Nagai, T., Nambu, A., Komiyama, Y., Kadoki, M., Tanahashi, Y., Akitsu, A., Kotaki, H., Sudo, K., Nakae, S., Sasakawa, C., Iwakura, Y.
- Journal Title
  
  Immunity 30
  
  Pages: 108-119
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] M. Virus binding to a plasma membrane receptor triggers interleukin-1α-mediated proinflammatory macrophage response in vivo2009
- Author(s)
  Di Paolo, N. C., Miao, E. A., Iwakura, Y., Kaja, M-K., Aderem, A., Flavell, R. A., Papayannopoulou, T., and Shayakhmetov, D.
- Journal Title
  
  Immunity
  
  Volume: 31 Pages: 110-121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages.2008
- Author(s)
  Ashino, T., Yamanaka, R., Yamamoto, M., Shimokawa, H., Sekikawa, K., Iwakura, Y., Shioda, S., Numazawa, S., Yoshida, T.
- Journal Title
  
  Mol. Immunol. 45
  
  Pages: 2106-2115
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] The roles of IL-17A in inflammatory immune responses and host defense against pathogens2008
- Author(s)
  Iwakura, Y.
- Journal Title
  
  Immunol. Rev 226
  
  Pages: 57-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015015
[Journal Article] The roles of IL-17A in inflammatory immune responses and host defense against pathogens2008
- Author(s)
  Iwakura, Y.
- Journal Title
  
  Immunol. Rev. 226
  
  Pages: 57-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041025
[Journal Article] Suppressive role of leukocyte cell-derived chemotaxin 2 in mouse anti-type II collagen antibody-induced arthritis.2008
- Author(s)
  Okumura, A., Saito, T., Otani, I., Kojima, K., Yamada, Y., Ishida-Okawara, A., Nakazato, K., Asano, M., Kanayama, K., Iwakura, Y., Suzuki, K., Yamagoe, S.
- Journal Title
  
  Arthritis Rheum. 58
  
  Pages: 413-421
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Human T-cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules.2008
- Author(s)
  Teruya, H., Tomita, M., Senba, M., Ishikawa, C., Tamayose, M., Miyazato, A., Yara, S., Tanaka, Y., Iwakura, Y., Fujita, J., Mori, N.
- Journal Title
  
  Retrovirology 5
  
  Pages: 86-86
- NAID
  120001374675
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction2008
- Author(s)
  Ogura, H., Murakami, M., Okyuyama, Y., Tsuruoka, M., Kitabayashi, C., Kanamoto, M., Nishihara, M., Iwakura, Y., and Hirano, T.
- Journal Title
  
  Immunity
  
  Volume: 29 Pages: 628-636
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] CD44 and Bak expression in IL-6 or TNF-a gene knockout mice after whole lung irradiation.2008
- Author(s)
  Sakai, M., Iwakawa, M., Iwakura, Y., Ohta, T., Tsujii, H., Imai, T.
- Journal Title
  
  J. Radiat. Res. 49
  
  Pages: 409-416
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction.2008
- Author(s)
  Ogura H., Murakami, M., Okyuyama, Y., Tsuruoka, M., Kitabayashi, C., Kanamoto, M., Nishihara, M., Iwakura, Y., Hirano, T*.
- Journal Title
  
  Immunity 29
  
  Pages: 628-636
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of Natural Killer T cells and IL-17.2008
- Author(s)
  Pichavant, M., Goya, S., Meyer, E.H., Johnston, R.A., Kim, H.Y., Matangkasombut, P., Zhu, M., Iwakura, Y., Savage, P.B., DeKruyff, R.H., Shore, S.A., Umetsu, D.T.
- Journal Title
  
  J. Exp. Med. 205
  
  Pages: 385-393
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Differential roles for IFN-g and IL-17 in experimental autoimmune uveoretinitis.2008
- Author(s)
  Yoshimura, T., Sonoda, K., Miyazaki, Y., Iwakura, Y., Ishibashi, T., Yoshimura, A., Yoshida, H.
- Journal Title
  
  Int. Immunol. 20
  
  Pages: 209-214
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] The roles of IL-17A in inflammatory immune responses and host defence against pathogens2008
- Author(s)
  Iwakura Y
- Journal Title
  
  Immunol Rev. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20240041
[Journal Article] The roles of IL-17A in inflammatory immune responses and host defense against pathogens2008
- Author(s)
  Iwakura, Y., Nakae, S., Saijo, S., and Ishigame, H.
- Journal Title
  
  Immunological Rev.
  
  Volume: 226 Pages: 57-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category.2008
- Author(s)
  Luger, D., Silver, P.B., Tang, J., Cua, D., Chen, Z., Iwakura, Y., Bowman, E.P., Sgambellone, N.M., Chan, C. -C., Caspi, R.R.
- Journal Title
  
  J. Exp. Med. 205
  
  Pages: 799-810
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Either a Th17 or a Th1 effector response can drive autoimmunity : conditions of disease induction affect dominant effector category2008
- Author(s)
  Luger, D., Silver, P. B., Tang, J., Cua, D., Chen, Z., Iwakura, Y., Bowman, E. P., Sgambellone, N. M., Chan, C.-C. and Caspi, R.
- Journal Title
  
  J. Exp. Med.
  
  Volume: 205 Pages: 799-810
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Increased fat-to-carbohydrate oxidation ratio in Il1ra^<-/-> mice on a high fat diet is associated with increased sympathetic tone2008
- Author(s)
  Chida, D., Hashimoto, O., Kuwahara, M., Sagara, H., Osaka, T., Tsubone, H., and Iwakura, Y.
- Journal Title
  
  Diabetologia
  
  Volume: 51 Pages: 1698-1706
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis.2008
- Author(s)
  Izcue, A., Hue, S., Buonocore, S., Arancibia-Carcamo, C.V., Ahern, P.P., Iwakura, Y., Maloy, K.J., Powrie, F
- Journal Title
  
  Immunity 28
  
  Pages: 559-570
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] IFN-γexpression in CD8+ T cells regulated by IL-6 signal is involved in superantigen-mediated CD4+ T cell death.2008
- Author(s)
  Atsumi, T., Sato, M., Kamimura, D., Moroi, A., Iwakura, Y., Betz, U.A., Yoshimura, A., Nishihara, M., Hirano, T., Murakami, M.
- Journal Title
  
  Int. Immunol. 21
  
  Pages: 73-80
- NAID
  10025383990
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Endogenous IL-17 does not play a significant role in the development of experimental murine allergic conjunctivitis.2008
- Author(s)
  Fukushima, A., Sumi, T., Ishida, W., Yamada, J., Iwakura, Y., Ueno, H.
- Journal Title
  
  Int. Arch. Allergy Imm. 147
  
  Pages: 206-212
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Deficiency of tumor necrosis factor-a and interferon-g in bone marrow cells synergistically inhibits neointimal formation following vascular injury.2008
- Author(s)
  Murayama, H., Takahashi, M., Takamoto, M., Shiba, Y., Ise, H., Koyama, J., Tagawa, Y., Iwakura, Y., Ikeda, U.
- Journal Title
  
  Cardiovascular Res. 80
  
  Pages: 175-180
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia.2008
- Author(s)
  Aujla, S.J., Fei, M., Pociask, D.A., Reinhart, T.A., Edeal, J., Gaus, K., Kreindler, J.L., Dubin, P.J., Zheng, M., Pilewski, J.M., Myerburg, M.M., Mason, C.A., Iwakura, Y., Kolls, J.K.
- Journal Title
  
  Nature Med. 14
  
  Pages: 275-281
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Host T cells are the main producers of IL-17 within the central nervous system during initiation of experimental autoimmune encephalomyelitis induced by adoptive transfer of Th1 cell lines.2008
- Author(s)
  Lees, J.R., Iwakura, Y., Russell, J.H.
- Journal Title
  
  J. Immunol. 180
  
  Pages: 8066-8072
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] IL-1 regulates the Cyp7a1 gene and serum total cholesterol level at steady state in mice.2008
- Author(s)
  Kojima, M., Ashino, T., Yoshida, T., Iwakura, Y., Sekimoto, M., Degawa, M.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 379
  
  Pages: 239-242
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis2008
- Author(s)
  Izcue, A., Hue, S., Buonocore, S., Arancibia-Carcamo, C. V., Ahern, P. P., Iwakura, Y., Maloy, K. J., and Powrie, F
- Journal Title
  
  Immunity
  
  Volume: 28 Pages: 559-570
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice.2008
- Author(s)
  Ito, R., Kita, M., Shin-Ya, M., Kishida, T., Urano, A., Takada, R., Sakagami, J., Imanishi, J., Iwakura, Y., Okanoue, T., Yoshikawa, T., Kataoka, K., Mazda, O.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 377
  
  Pages: 12-16
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1a released from dying cells.2008
- Author(s)
  Eigenbrod, T., Park, J-H., Harder, J., Iwakura, Y., Nunez, G.
- Journal Title
  
  J. Immunol. 181
  
  Pages: 8194-8198
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] The role of DCIR in the development of autoimmune diseases2008
- Author(s)
  Fujikado, N., Saijo, S., Yonezawa, T., Shimamori, K., Ishii, A., Sugai, S., Kotaki, H., Sudo, K., Nose, M., and Iwakura, Y.
- Journal Title
  
  Cytokine
  
  Volume: 43 Pages: 244-244
- NAID
  40017145116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] CCL2 recruitment of IL-6 producing CD11b+ monocytes to the draining lymph nodes during the initiation of TH17-dependent B cellmediated autoimmunity.2008
- Author(s)
  Bai, Y, Liu, R., Huang, D., La Cava, A., Tang, Y., Iwakura, Y., Campagnolo, D.I., Vollmer, T.L., Ransohoff, R.M., Shi, F.
- Journal Title
  
  Eur. J. Immunol. 38
  
  Pages: 1877-1888
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] IL-23 and Th17 cells enhance Th2 cell-mediated eosinophilic airway inflammation in mice.2008
- Author(s)
  Wakashin, H., Hirose, K., Maezawa, Y., Kagami, S., Suto, A., Watanabe, N., Saito, Y., Hatano, M., Tokuhisa, T., Iwakura, Y., Puccetti, P., Iwamoto, I., Nakajima, H.
- Journal Title
  
  Am. J. Respir. Crit. Care Med. 178
  
  Pages: 1023-1032
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Toll-like receptor 2 (TLR2) and dectin-1 contribute to the production of IL-12p40 by bone marrow-derived dendritic cells infected with Penicillium marneffei.2008
- Author(s)
  Nakamura, K., Miyazato, A., Koguchi, Y., Adachi, Y., Ohno, N., Saijo, S., Iwakura, Y., Takeda, K., Akira, S., Fujita, J., Ishii, K., Kaku, M., Kawakami, K.
- Journal Title
  
  Microbes Infect. 10
  
  Pages: 1223-1227
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Development of proteogylcan-induced arthritis is independent of IL-17.2008
- Author(s)
  Doodes, P.D., Cao, Y., Hamel, K., Wang, Y., Hutas, G., Iwakura, Y., Finnegan, A.
- Journal Title
  
  J. Immunol. 181
  
  Pages: 329-337
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway.2008
- Author(s)
  Nakamura, K., Miyazato, A., Gang, X., Hatta, M., Inden, K., Aoyagi, T., Takeda, K., Akira, S., Saijo, S., Iwakura, Y., Adachi, Y., Ohno, N., Suzuki, K., Fujita, J., Kaku, M., Kawakami, K.
- Journal Title
  
  J. Immunol. 180
  
  Pages: 4067-4074
- Data Source
  KAKENHI-PROJECT-19059006
[Journal Article] The roles of IL-17A in inflammatory immune responses and host defense against pathogens.2008
- Author(s)
  iwakura, Y.
- Journal Title
  
  Immunol. Rev., 226
  
  Pages: 57-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009
[Journal Article] Contribution of IL-1 to resistance to Streptococcus pneumoniae infection2008
- Author(s)
  Kafka, D., Ling, E., Feldman, G., Benharroch, D., Voronov, E., Givon-Laci, N., Iwakura, Y., Dagan, R.,

Iwakura Yoichiro 岩倉 洋一郎

IWAKURA Yoichiro 岩倉 洋一郎

岩倉 洋一朗 イワクラ ヨウイチロウ

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of autoimmunity induced by excess IL-1 signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of CTRP3, CTRP6 and their receptors using gene targeted micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of inflammation, allergy, fibrosis, and tumorigenesis through the innate immune systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

自然免疫受容体を介した腸管免疫の制御と全身免疫への影響の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Analysis of physiological function of C-type lectin receptor and application to disease controlPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of an IL-1-related gene-manipulated mouse library and dissection of the gene-targeted mice, aiming at identifying new therapeutic targets for diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

創薬標的の探索を目指したIL-1関連遺伝子改変マウスライブラリーの作製研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Iwakura Yoichiro 岩倉洋一郎

IWAKURA Yoichiro 岩倉洋一郎

岩倉洋一朗イワクラヨウイチロウ