TOKUHISA Takeshi 徳久剛史

Researcher Number	20134364
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Affiliation (based on the past Project Information) *help	2014: 千葉大学, 学長 2011 – 2013: 千葉大学, 医学(系)研究科(研究院), 教授 2001 – 2012: Chiba University, Graduate School of Medicine, Professor, 大学院・医学研究院, 教授 2005 – 2006: Chiba University, Graduate School of Medicine, Professor, 大学院医学研究院, 教授 1998 – 2002: Graduate School of Medicine, Developmental Genetics Professor, 大学院・医学研究科, 教授 … More 1993 – 2000: 千葉大学, 医学部, 教授 1996: 千葉大学, 医学部・高次機能制御研究センター, 教授 1994 – 1995: 千葉大学, 医学部・高次機能センター, 教授 1990 – 1991: 神戸大学, 国際交流センター, 教授 1986 – 1991: 神戸大学, 医学部, 教授 1986: 千葉大学, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator Immunology / Immunology / Biological Sciences / Circulatory organs internal medicine / Experimental pathology / Experimental pathology / 膠原病・アレルギー・感染症内科学 / 免疫の制御機構 / Laboratory animal science / 内科学一般 / Functional basic dentistry … More Except Principal Investigator … More Biological Sciences / Immunology / Immunology / 膠原病・アレルギー・感染症内科学 / Pathological medical chemistry / Gastroenterology / Hematology / Respiratory organ internal medicine / Pathological medical chemistry / 内分泌・代謝学 / Nerve anatomy/Neuropathology / General surgery / Circulatory organs internal medicine / Digestive surgery / Otorhinolaryngology / Respiratory organ internal medicine / 内科学一般 / アレルギー Less
Keywords	Principal Investigator トランスジェニックマウス / BCL6 / アポトーシス / 胚中心 / ノックアウトマウス / メモリーB細胞 / c-Fos / c-fos / クラススイッチ / BAZF … More / IL-5 / B細胞 / 転写抑制 / Bcl6 / 転写因子 / サイトカイン / AP-1 / 好酸球 / メモリーT細胞 / 体細胞突然変異 / 遺伝子 / Bリンパ球 / Transgenic mice / 心筋細胞 / 転写抑制活性 / ゲノム / 癌 / IL-21 / 免疫学 / Apoptosis / ADAR1 / c-jun / 幼若B細胞 / 心筋炎 / ノックアウト(KO)マウス / リンパ球 / 好酸球性アレルギー / アレルギー炎症 / 遺伝子治療 / Th1細胞 / 好酸球性アレルギー炎症 / CD8T細胞 / 自己抗体 / 免疫記憶 / IgE抗体 / Ｂリンパ球 / 血球系幹細胞 / Memory B cells / Germinal center / 発現制御 / 胚中心B細胞 / 遺伝子欠損マウス / anti-sense RNA / cーfos / トランスジェニックスマウス / メモリ-B細胞 / cーmyc / vーjun / B細胞リンフォ-マ / Mx / Mxプロモーター / P53 / P21 / 細胞周期 / TUNEL法 / B細胞初期分化 / アポトーシス関連遺伝子 / 終末分化細胞死 / 骨髄細胞移植 / リンフォーマ / 精母細胞 / クリプトパッチ / 腸管免疫 / 点突然変異 / 胸腺細胞 / 粘膜免疫 / 多能性造血幹細胞 / 骨髄キメラ / ウイルスベクター / Th2細胞 / Bcl6-欠損(KO)マウス / 転写抑制因子 / central memory / effector memory / 胸腺腫 / 放射線 / 老化 / ストレス / Niche / CXCR4 / Long-lived Plasma細胞 / ヘルパーT細胞 / アレルギー疾患 / Igクラススイッチ / 抗体産生細胞 / 獲得免疫 / 体細胞超突然変異 / 発生・分化 / 濾胞ヘルパーＴ細胞 / 胸腺 / 記憶Ｔ細胞 / 血球糸幹細胞 / ドーマントな状態 / 発現誘導型遺伝子 / Mature B cells / Hematopoietic stem cells / Dormant satae / Inducible promoter / 特発性心筋性 / モデルマウス / Knockout mice / Transcriptional repressor / Cardiac myocytes / リンパ腫 / 欠損マウス / リンパ種 / Autoantibody / Lymphoma / Deficient mice / 疾患モデルマウス / IgE産生メモリーB細胞 / Allergic inflammation / Gene therapy / Eosinophil / Homeostatic Proliferation / Central Memory T Cell / CD8 T Cells / エフェクター細胞 / Memory T cells / Transcription factor / Homeostatic proliferation / Central memory T cells / CD8 T cells / アレルギー・喘息 / 感染症 / 免疫記憶細胞 / 胚工学 / STAT3 / Blimp-1 / Follicular helper T cell / Allergy / CO Gene / Infectious Disease / Transcription / Immunology / Immune Memory Cell / Transcription Factor / Transgenic Technology / Ig遺伝子のスイッチ領域 / somatic hypermutation / immunoglobulin class-switch region / germinal center B cells / memory B cells / class-switch / gene-deficient mice / immunology / target gene / cancer / genome / gene regulation / クラスII主要細織適合抗原 / Ia抗原 / 遺伝子導入 / クラスII主要組織適合抗原 / Antisense RNA / プロトプラスト法 / 抗原提示能 / class II major hitocompatibility antigen / Gene transfection / Protoplast method / antigen presenting activity … More Except Principal Investigator トランスジェニックマウス / BCL6 / アポトーシス / 転写因子 / ノックアウトマウス / 細胞周期 / Ncx / T細胞 / Bcl6 / サイトカイン / リンパ球 / c-fos / TIAP / アレルギー / BAZF / 造血幹細胞 / survivin / 神経堤細胞 / 遺伝子欠損マウス / Nczf / B細胞 / CD43 / HOX11 / ホメオボックス遺伝子 / 細胞増殖 / 腸管神経節 / IL-5 / マクロファージ / リンパ腫 / 気管支喘息 / Th2サイトカイン / 転写抑制因子 / 免疫学 / 遺伝子 / 発現制御 / 発生・分化 / 単クローン抗体 / 抗ガングリオシド抗体 / シグナル伝達 / STAT / トランスジェニック・マウス / 神経細胞死 / Survivin / B細胞分化 / アクチン結合蛋白 / 放射線誘導性腫瘍 / クロマチンリモデリング / 免疫記憶 / CD8T細胞 / CD4T細胞 / IgE / ts変異株 / V_H gene replacement / circular DNA / transcription factor / SSCP / RDA / DNA結合 / DNA binding / cDNA array / DNA chip / mRNA / DNAチップ / c-Fos / Hox11L1 / Intestinal neuronal dysplasia / Knockout mice / Transcription factor / ロイコトリエン / ケモカイン / 好酸球 / bronchial asthma / chemokine / 転写抑制 / 間質性肺炎 / 線維化 / 気道上皮細胞 / 遺伝子導入マウス / 標的遺伝子 / 樹状細胞 / allergy / 熱中性子捕促療法 / シクロデキストリン / neuropeptide Y / 神経ペプチド / Germinal Center(胚中心) / 記憶細胞 / 体細胞点変異 / 代替L鎖 / VpreB-3 / 癌遺伝子 / 癌抑制遺伝子 / 多段階発癌 / 疾患モデル / 遺伝子発現誘導 / 関連遺伝子 / 臓器形成 / 胚中心B細胞 / V_H遺伝子 / 体細胞超変異 / error prone DNA repair / 高親和性B細胞 / CD40 / B7-2 / MAPキナーゼ / キャップサイト / サイレンサー / 増殖抑制 / 抗原受容体 / 免疫異常 / 免疫病 / レセプター / 情報伝達 / ノックアオウト・マウス / インターフェロン / インターフェロン受容体 / ニューロン / 中脳ドーパミンニューロン / 小脳顆粒細胞 / c-jun / トランスジェニック / マウス / NID / Caspase3 / 類似遺伝子 / BIRドメイン / プロモーター領域 / caspase3 / AP-1 / NF-IL-6 / T細胞分化 / リンパ球前駆細胞 / 胚中心 / 遺伝子再構成 / プレB細胞レセプター / Btk / BLNK / NK細胞 / CD94 / トランスジェニックマウ / 欠損マウス / 精母細胞 / 減数分裂 / IAPファミリー / kelchファミリー / ND-1 / ドキソルビシン / 心筋症 / 心筋細胞 / 放射線発癌 / 胸腺リンパ腫 / Kelchファミリー蛋白 / Doxorubicin / Nd-1 / β-catenin / 発癌 / Kelch / Nd1 / 接着分子 / 転移 / β-カテニン / 腫瘍 / Th2細胞 / ヒストン脱アセチル化 / DNA損傷 / IL-4 / 記憶T細胞 / KLRG1 / メモリーＴ細胞 / ＣＤ８Ｔ細胞 / Ｂｃｌ６ / メモリーＴ　細胞 / ＣＤ８　Ｔ　細胞 / mTOR / ＰＨＦ１１ / ＩｇＥ / PHF11 / クラススイッチ / Allergy / 免疫 / LL-PCs / 抗体産生 / アレルギー・ぜんそく / 細胞・組織 / 脱腫瘍化・分化誘導機構 / 遺伝子発現抑制機構 / 脱腫瘍化・分化関連遺伝子 / Abelsonマウス白血病ウィルス / 幼若Bリンフォーマ / ts変異株ウィルスDNA / 熱中性子捕捉療法 / 悪性黒色腫 / 幼若B細胞特異的遺伝子 / Ig gene superfamily / B細胞成熟 / μ鎖発現 / μ鎖輸送 / CD45R / Macー1陽性細胞 / μ鎖複合体 / 前B細胞 / virgin B細胞 / B cell maturation / mu chain expression / B cell specific gene / surrogate L chains / lg gene super family / mu chain transport / B細胞生存維持 / 細胞周期調節 / CD43トランスジェニックマウス / 免疫反応 / IgM抗体産生 / IgG抗体産生 / B細胞dynamics / 細胞内相互作用 / CD43強発現マウス / IgMb抗体産生 / ホモ遺伝子強発現マウス / ターゲッティング / CD43ゲノム遺伝子 / Cre-loxPシステム / 細胞生存維持 / B cell survival / cell cycle regulation / CD43 transgenic mice / immune response / lgM antibodies / lgG antibodies / B cell dynamics / 胸腺 / 分化 / 前駆細胞 / ストローマ細胞 / 正の選択 / 決定 / 生長因子 / 骨髄 / 胸腺ストローマ細胞 / 増殖因子 / 正・負の選択 / thymus / T cell / differentiation / hematopoietic stem cell / progenitor / stromal cell / positive selection / ホメオボックス / ヒルシュスプルング病類縁疾患 / 遺伝子発現調節 / 疾患モデル動物 / NCX / Hirschsprung-related disease / homebox / HCV core蛋白 / トランスジェニックマウス / Suppression subtractive hybridization / C型肝炎ウイルスコア蛋白 / サブトラクション法 / 肝細胞癌 / C型慢性肝炎 / Northern blotting / C型肝炎ウイルス / HCVコアタンパク / Fasシグナル伝達系 / HCV core protein / transgenic mouse / suppression subtractive hybridization / Hematopoietic stem cells / Transcriptional factor / Interstinal neuronal dysplasia / 膀胱神経節 / Yeast one hybrid / Neural crest cells / プロスタグランデイン / LTC4合成酵素 / ロイコトリエンC4合成酵素 / eosinophil / FLAP / LTC4 / leukotriene / prostaglandin / LTC4 synthase / 血球分化 / C-fos / Differentiation / macrophage / Memory B cell / Th2 cytokine / lymphocyte / transcriptional repression / 劇症肝炎 / 肝再生 / 蛋白合成 / DNAマイクロアレイ / osteopontin / 遺伝子発現 / オーバル細胞 / IGFBP1 / SNP解析 / FAS / FLIP / FULMINANT HEPATITIS / LIVER REGENERATION / PROTEIN SYNTHESIS / DNA MICROARRAY / OSTEOPONTIN / GENE EXPRESSION / OVAL CELL / 気道炎症 / トイコトリエン / 転写制御因子 / 線維芽細胞 / interstitial peumonia / fibrosis / brnchial epithelial cells / leukotrien / bronchial inflammation / gene Knock out mouse / gene transgenic mouse / 肺線維症 / 細胞死 / transcriptional repressor / Pulmonary fibrosis / Apoptosis / alveolar epithelial cell / chromatin remodeling / Hirschsprung病類縁疾患 / Zinc finger protein / DNA結合配列 / クロマチン免疫沈降 / Neural crest cell / Target genes / Neural cell death / Transcriptional repressor / Hirschsprung related diseases / Th2炎症 / 遣伝子欠損マウス / dendritic cells / regulation of gene expression / development differentiation / gene-deficient mice / 腸管神経細胞 / zinc finger蛋白 / Neural Crest cells / Cell proliferation / 発王制御 / BCL6欠損マウス / CD8陽性樹状細胞 / CD4陽性樹状細胞 / 抗原提示細胞 / Immunology / target gene / gene regulation / development / 抑制T細胞 / Vα14α鎖遺伝子 / 多様性欠除 / 自己反応性レパトア / 胸腺非依存性の選択 / 分子生物学 / 免疫系ネットワ-ク / 抑制T細胞リセプター / α鎖遺伝子 / 免疫応答調節 / 抑制T細胞レセプター / V_α遺伝子ゲノム塩基配列 / Antiーsense RNA / 抗原レセプター / 内部抗原 / キメラ・マウス / Suppresser T cell receptor / T cell repertoire / Homogenous TCR usage / Valpha14 TCR gene family / TCRalpha-chain / Self reactive repertoire / Abelsonマウス白血病ウイルス / リンパ球分化 / Ig遺伝子発現機構 / 胎生期胸腺由来幼若T細胞 / 胸腺由来B細胞 / 温度感受性変異ウイルス株 / 抗体遺伝子発現 / lymphoid cell differentiation / programming of Ig gene expression Less

Heterogeneity of naive CD4 T cellsPrincipal Investigator
- Principal Investigator
  
  TOKUHISA Takeshi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Chiba University
Molecular mechanisum of memory CD8 T cell differentiation
- Principal Investigator
  
  SAKAMOTO Akemi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Chiba University
A role of Plant homeodomain finger protein 11 in class switch recombination to IgE in murine activated B cells
- Principal Investigator
  
  ARIMA Masafumi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Chiba University
アレルゲン特異的ＩｇＥ型長期生存抗体産生細胞の形成阻害剤の開発
- Principal Investigator
  
  佐々木絢子 (稲嶺絢子 / 佐々木絢子(稲嶺絢子))
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
Molecular mechanisms of memory B cell differentiation in germinal centersPrincipal Investigator
- Principal Investigator
  
  TOKUHISA Takeshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Chiba University
A role of ADAR1 in induction of somatic hypermutationPrincipal Investigator
- Principal Investigator
  
  TOKUHISA Takeshi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Chiba University
アレルギー性炎症におけるPHF11ファミリーの機能解析と新規治療法の開発Principal Investigator
- Principal Investigator
  
  徳久剛史
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Chiba University
胚中心における末梢性自己免疫寛容誘導機序Principal Investigator
- Principal Investigator
  
  徳久剛史
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Survival mechanism of memory B cellsPrincipal Investigator
- Principal Investigator
  
  TOKUHISA Takeshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Chiba University
Mechanism of memory CD8 T cell generation
- Principal Investigator
  
  SAKAMOTO Akemi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Chiba University
細胞寿命に関する転写因子レベルでの研究Principal Investigator
- Principal Investigator
  
  徳久剛史
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Chiba University
気管支喘息における新規のTh2細胞維持機構の解明と新規治療の研究開発
- Principal Investigator
  
  有馬雅史
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Chiba University
A role of Bcl6 in regulation of somatic hypermutation in the immunoglobulin genePrincipal Investigator
- Principal Investigator
  
  TOKUHISA Takeshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Chiba University
Regulation of neural crest cell proliferation, differentiation and death in normal development and diseases
- Principal Investigator
  
  HATANO Masahiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Chiba University
Role of Bcl6 for generation of CD8+ dendritic cells
- Principal Investigator
  
  SAKAMOTO Akemi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Chiba University
新規アクチン結合蛋白Nd1による細胞骨格制御と発癌
- Principal Investigator
  
  幡野雅彦
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
消化器癌の浸潤・転移制御を行うkelch関連遺伝子を用いた新しい遺伝子治療の開発
- Principal Investigator
  
  軍司祥雄
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University
A role of Bcl6 in induction of somatic hypermutation in immunoglobulin genePrincipal Investigator
- Principal Investigator
  
  TAKESHI Tokuhisa
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Chiba University
Regulation for expression of chemokine genes in the gene cluster including CCL2/MCP-1 by BCL-6
- Principal Investigator
  
  ARIMA Masafumi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Chiba University Graduate school of Medicine
Molecular mechanism of neural crest cell differentiation, proliferation and death
- Principal Investigator
  
  HATANO Masahiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Chiba University
A role of Bc16 in differentiation of dendritic cells
- Principal Investigator
  
  SAKAMOTO Akemi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  アレルギー
- Research Institution
  Chiba University
免疫記憶の成立機構に関する転写因子レベルでの解析Principal Investigator
- Principal Investigator
  
  徳久剛史
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
BCL6がん遺伝子のリンパ球腫瘍化機序の解析Principal Investigator
- Principal Investigator
  
  徳久剛史
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
新規アクチン結合蛋白Nd1による細胞骨格制御と発癌
- Principal Investigator
  
  幡野雅彦
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Study for Development and Maintenance of mune MemoryPrincipal Investigator
- Principal Investigator
  
  TOKUHISA Takeshi
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Study on molecular mechanisms of development of interstitial pneumonia
- Principal Investigator
  
  FUKUDA Takeshi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Dokkyo Medical University School of Medicine
TIAP/Survivinによる細胞死、細胞周期の制御と発癌機構の解析
- Principal Investigator
  
  幡野雅彦
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
IAPファミリー蛋白TIAP/Survivinによる細胞死、細胞周期の制御と発癌
- Principal Investigator
  
  幡野雅彦
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Induction Mechanisms of Memory T CellsPrincipal Investigator
- Principal Investigator
  
  TOKUHISA Takeshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Chiba University
Functional analysis of BCL6 on allergic inflammation
- Principal Investigator
  
  ARIMA Masafumi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  CHIBA UNIVERSITY
STUDIES ON HOST FACTORS RELATED TO FULMINANT HEPATITIS
- Principal Investigator
  
  YOKOSUKA Osamu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  CHIBA UNIVERSITY
IAPファミリー蛋白TIAP/survivinによる細胞死,細胞周期の制御と発癌
- Principal Investigator
  
  幡野雅彦
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
TIAP/Survivinによる細胞死,細胞周期の制御と発癌機構
- Principal Investigator
  
  幡野雅彦
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
新規アクチン結合蛋白ND-1の機能と心疾患病態解析への応用
- Principal Investigator
  
  幡野雅彦
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Chiba University
Control of hematopoietic cell differentiation by c-Fos and Bcl6
- Principal Investigator
  
  OKADA Seiji
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University
  Chiba University
AP-1遺伝子群による造血制御
- Principal Investigator
  
  岡田誠治
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
免疫システム構築の情報伝達制御
- Principal Investigator
  
  烏山一
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
末梢リンパ組織における免疫系再構築のシグナル伝達機構Principal Investigator
- Principal Investigator
  
  徳久剛史
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
BCL6の強発現によるリンパ球腫瘍化能の解析
- Principal Investigator
  
  岡田誠治
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
新しいIAPファミリー蛋白TIAPによる細胞死、細胞周期の制御機構解析
- Principal Investigator
  
  幡野雅彦
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
好酸球性炎症の抑性機序の解析Principal Investigator
- Principal Investigator
  
  徳久剛史
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Chiba University
Molecular genetics of neurocristopathy
- Principal Investigator
  
  HATANO Masahiko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Chiba University
Functinal analysis of leukotrine C4 synthase gene in the pathogenesis of asthma
- Principal Investigator
  
  FUKUDA Takeshi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Dokkyo University School of Medicine
Development of the gene therapy model for allergic diseasesPrincipal Investigator
- Principal Investigator
  
  TOKUHISA Takeshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Chiba University
BCL6ファミリーによるリンパ球腫瘍化能の解析Principal Investigator
- Principal Investigator
  
  徳久剛史
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Chiba University
転写抑制因子(BCL6遺伝子群とポリコーム遺伝子群)による造血制御
- Principal Investigator
  
  岡田誠治
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
終末分化した心筋細胞の機能維持機構の解析Principal Investigator
- Principal Investigator
  
  徳久剛史
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Chiba University
多臓器不全発症におけるアポトーシスの関与に関する研究
- Principal Investigator
  
  平澤博之
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Chiba University
Induction mechanisms of B cell self-toleranacePrincipal Investigator
- Principal Investigator
  
  TOKUHISA Takeshi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Immunology
- Research Institution
  Chiba University
Functional analysis of HCV core protein using HCV core transgenic mouse
- Principal Investigator
  
  IMAZEKI Fumio
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
Control of Hematopoiesis by AP-1 and Bcl6
- Principal Investigator
  
  OKADA Seiji
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Chiba University
BCL6ファミリーによる終末分化細胞死の抑制機序の解析Principal Investigator
- Principal Investigator
  
  徳久剛史
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Chiba University
DEVELOPMENT OF ANIMAL MODEL OF DILATED CARDIOMYORATHYPrincipal Investigator
- Principal Investigator
  
  TOKUHISA Takishi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Chiba University
Analysis of NCX gene mutation in patients with Hirschsprung-related disease
- Principal Investigator
  
  HATANO Masahiko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Chiba University
BCL6欠損マウスに見られた終末分化細胞死の誘導機序の解析Principal Investigator
- Principal Investigator
  
  徳久剛史
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba University
Ncxノックアウトマウスにおける巨大結腸症と神経細胞死
- Principal Investigator
  
  幡野雅彦
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba University
FUNCTIONAR ROFE OF C-FOS IN DIFFERENTIATION AND PROLIFERATION OF MATURE B CELLSPrincipal Investigator
- Principal Investigator
  
  TOKUHISA Takeshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  免疫の制御機構
- Research Institution
  CHIBA UNIVERSITY
c-Fosによるアポトーシス誘導機序の解析Principal Investigator
- Principal Investigator
  
  徳久剛史
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba University
情報伝達とリンパ球の機能分化
- Principal Investigator
  
  宮園浩平
- Project Period (FY)
  1996 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Japanese Foundation For Cancer Research
メモリーB細胞分化の分子機構の解析Principal Investigator
- Principal Investigator
  
  徳久剛史
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba University
B細胞初期分化におけるc-FosやBCL6遺伝子の機能解析Principal Investigator
- Principal Investigator
  
  徳久剛史
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Chiba University
神経細胞のアポトーシスにおけるc-fos,c-junの役割-遺伝子操作マウスにおける検討-
- Principal Investigator
  
  仙波恵美子
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Wakayama Medical University
B細胞免疫寛容とメモリーB細胞分化の分子機構の解析Principal Investigator
- Principal Investigator
  
  徳久剛史
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba University
B細胞分化・成熟分子機構の解明及びその制御
- Principal Investigator
  
  竹森利忠
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  国立予防衛生研究所
HOX11によるリンパ球腫瘍化の分子機構の解析
- Principal Investigator
  
  幡野雅彦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba University
B細胞初期分化増殖におけるC-Fosがん遺伝子の機能解析Principal Investigator
- Principal Investigator
  
  徳久剛史
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Chiba University
Studies on the mechanism of T cell development in the thymus
- Principal Investigator
  
  KATSURA Yoshimoto
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  KYOTO UNIVERSITY
B細胞免疫寛容とメモリーB細胞分化の分子機構の解析Principal Investigator
- Principal Investigator
  
  徳久剛史
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba University
B細胞分化・成熟分子機構の解明およびその制御
- Principal Investigator
  
  TAKEMORI Toshitada
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  国立予防衛生研究所
遺伝子導入動物による発癌の研究
- Principal Investigator
  
  樋野興夫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Japanese Foundation For Cancer Research
HOX11によるリンパ球腫瘍化の分子機構の解析
- Principal Investigator
  
  幡野雅彦
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba University
T細胞アポプトーシスにおけるHOX11の役割の解析
- Principal Investigator
  
  幡野雅彦
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Chiba University
AP-1のB細胞初期分化における機能解析Principal Investigator
- Principal Investigator
  
  徳久剛史
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Chiba University
Functional role of CD43 in immune system
- Principal Investigator
  
  NAGAOKA Hitoshi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  National Institute of Health of Japan
リンパ球増殖におけるc-fosがん遺伝子産物の機能解析Principal Investigator
- Principal Investigator
  
  徳久剛史
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Chiba University
AP-1のB細胞分化における機能解析Principal Investigator
- Principal Investigator
  
  徳久剛史
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Chiba University
トランスジェニックマウスを用いた神経ペプチドの生理的,病態生理的意義に関する研究
- Principal Investigator
  
  乾明夫
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kobe University
生体内発癌におけるがん遺伝子相互の機能的連鎖に関する研究Principal Investigator
- Principal Investigator
  
  徳久剛史
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kobe University
The analysis of B cell differentiation and maturation
- Principal Investigator
  
  TAKEMORI Toshitada
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  National Institute of Health
ホウ酸熱中性子補促療法の適応拡大に関する研究副題:単クローン抗体利用の^<10>B集積,即発γ線による癌診断,L体単離による^<10>BーBPAの薬効増強
- Principal Investigator
  
  三島豊
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kobe University
ホウ素熱中性子捕捉療法の適応拡大に関する研究副題:単クローン抗体利用の^<10>B集積、即発γ線による癌診断、L体単離による^<10>B-BPAの薬効増強
- Principal Investigator
  
  三島豊
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kobe University
温度感受性レトロウィルスを用いた腫瘍発生に伴う造血細胞分化抑制の解析
- Principal Investigator
  
  竹森利忠
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Chiba University
Analysis of biological roles of class II major histocompatibility antigen by anti-sense RNAPrincipal Investigator
- Principal Investigator
  
  TOKUHISA Takeshi
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Kobe University
Molecualr mechanisms of cell-cell interactions and T cell repertoire formation.
- Principal Investigator
  
  TANIGUCHI Masaru
- Project Period (FY)
  1986 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  Chiba University
The analysis of lymphoid cell differention by using cell lines transformed with a ts mutant of Abelson murine leukemia viurs.
- Principal Investigator
  
  TAKEMORI Toshitaka
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Chiba University

All 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book

[Book] Recent Res. Devel. Immunology, Roles of Bcl6 in dendritic cell homeostasis2012
- Author(s)
  Akemi Sakamoto, Hiroyuki Matsuyama, Yuki Hayashi, Shun Hasegawa, Yuta Iijima、Mani Kohno, Jin Pan, Sumina Inage and Takeshi Tokuhisa
- Publisher
  Research Signpost
- Data Source
  KAKENHI-PROJECT-24590573
[Book] 胚中心におけるB細胞の移動とCXCR4の発現調節2012
- Author(s)
  吉田修也,徳久剛史
- Publisher
  科学評論社、臨床免疫・アレルギー科
- Data Source
  KAKENHI-PROJECT-23659239
[Book] B細胞免疫記憶研究の最先端と今後の展望2012
- Author(s)
  徳久剛史
- Publisher
  羊土社、実験医学
- Data Source
  KAKENHI-PROJECT-23659239
[Book] 耐性と免疫記憶2012
- Author(s)
  徳久剛史
- Publisher
  東京医学社、小児内科
- Data Source
  KAKENHI-PROJECT-23659239
[Book] 改訂:培養細胞実験(10-4血液細胞実験医学別冊ハンドブック)(黒木登志夫、許南浩編)2009
- Author(s)
  坂本明美、徳久剛史
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-20590486
[Book] 改訂:培養細胞実験ハンドブック黒木登志夫、許南浩編、実験医学別冊2009
- Author(s)
  坂本明美、徳久剛史
- Total Pages
  329
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-20590486
[Book] 改定)培養細胞実験ハンドブック10-4血液細胞2008
- Author(s)
  黒木登志夫、許南浩編、坂本明美、徳久剛史
- Total Pages
  329
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-20590486
[Journal Article] DA-Raf-dependent inhibition of the Ras-ERK signaling pathway in type 2 alveolar epithelial cells controls alveolar formation2014
- Author(s)
  Watanabe-Takano H, Takano K, Sakamoto A, Matsumoto K, Tokuhisa T, Endo T, Hatano M.
- Journal Title
  
  Proc Natl Acad Sci USA.
  
  Volume: 111
- DOI
  10.1073/pnas.1321574111
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590573, KAKENHI-PUBLICLY-25117706, KAKENHI-PROJECT-25460380, KAKENHI-PROJECT-25670104, KAKENHI-PROJECT-25670227, KAKENHI-PROJECT-26440045
[Journal Article] Plant homeodomain finger protein 11 promotes class switch recombination to IgE in murine activated B cells2014
- Author(s)
  Ikari J, Inamine A, Yamamoto T, Watanabe-Takano H, Yoshid a N, Fujimura L, Taniguchi T, Sakamoto A, Hatano M, Tatsumi K, Tokuhisa T, Arima M.
- Journal Title
  
  Allergy
  
  Volume: 69 Pages: 223-230
- DOI
  10.1111/all.12328
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-12J05613, KAKENHI-PROJECT-23390121, KAKENHI-PROJECT-24590573, KAKENHI-PROJECT-24591460, KAKENHI-PROJECT-24592575, KAKENHI-PROJECT-25460380, KAKENHI-PROJECT-25460942, KAKENHI-PROJECT-25670227
[Journal Article] Generation of tissue-specific H-2Kd transgenic mice for the study of Kdrestricted malaria epitopespecific CD8+ T-cell responses in vivo2013
- Author(s)
  Huang J, Li X, Kohno K, Hatano M, Tokuhisa T, Murray PJ, Brocker T, and Tsuji M
- Journal Title
  
  J.Immunol.Methods
  
  Volume: 387 Pages: 254-261
- DOI
  10.1016/j.jim.2012.10.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390121, KAKENHI-PROJECT-23659428, KAKENHI-PROJECT-25460380
[Journal Article] ADAR1 protein induces adenosine-targeted DNA mutations in senescent Bcl6 gene-deficient cells2013
- Author(s)
  Tsuruoka, N., Arima, M., Yoshida, N., Okada, S., Sakamoto, A., Hatano, M., Satake, H., Arguni, E., Wang, Ji-Y., Yang,J-H., Nishikura, K., Sekiya, S., Shozu, M., and Tokuhisa, T.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Pages: 826-836
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659239
[Journal Article] ADAR1 protein induces adenosine-targeted DNA mutations in senescent Bcl6 gene-deficient cells2013
- Author(s)
  Tsuruoka, N., Arima, M., Yoshida, N., Okada, S., Sakamoto, A., Hatano, M., Satake, H., Arguni, E., Wang, J.-Y., Yang, J.-H., Nishikura, K., Sekiya, S., Shozu, M. and Tokuhisa, T.
- Journal Title
  
  J Biol Chem
  
  Volume: 288 Pages: 826-36
- DOI
  10.1074/jbc.m112.365718
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590445, KAKENHI-PROJECT-23390121, KAKENHI-PROJECT-23659428, KAKENHI-PROJECT-23659772, KAKENHI-PROJECT-24591460, KAKENHI-PROJECT-25460380, KAKENHI-PROJECT-25460604, KAKENHI-PROJECT-25670227
[Journal Article] Generation of tissue- specific H-2K(d) transgenic mice for the study of K(d)-restricted malariaepitope-specific CD8(+) T-cell responses in vivo2013
- Author(s)
  Huang, J., Li, X., Kohno, K., Hatano, M., Tokuhisa, T., Murray, P.J., Brocker, T., and Tsuji, M.
- Journal Title
  
  J. Immunol. Methods
  
  Volume: 387 Pages: 254-261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659239
[Journal Article] Lack of both α2-antiplasmin and plasminogen activator inhibitor type-1 induces high IgE production.2013
- Author(s)
  Okada K, Ueshima S, Kawao N, Yano M, Tamura Y, Tanaka M, Sakamoto A, Hatano M, Arima M, Miyata S, Nagai N, Tokuhisa T, and Matsuo O
- Journal Title
  
  Life Sciences
  
  Volume: 93 Pages: 89-95
- DOI
  10.1016/j.lfs.2013.05.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390121, KAKENHI-PROJECT-23590268, KAKENHI-PROJECT-23590291, KAKENHI-PROJECT-24590573, KAKENHI-PROJECT-24591460, KAKENHI-PROJECT-24790227, KAKENHI-PROJECT-25460380, KAKENHI-PROJECT-25670227
[Journal Article] Kinetics and protective role of autophagy in a mouse cecal ligation and puncture-induced sepsis2013
- Author(s)
  Takahashi W, Watanabe E, Fujimura L, Watanabe-Takano H, Yoshidome H, Swanson PE, Tokuhisa T, Oda S, and Hatano M
- Journal Title
  
  Crit. Care
  
  Volume: 17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390121
[Journal Article] Leukotriene (LT)C4 aggravates bleomycin-induced pulmonary fibrosis in mice2013
- Author(s)
  Hirata H, Arima M, Fukushima Y, Sugiyama K, Tokuhisa T, and Fukuda T
- Journal Title
  
  Respirology
  
  Volume: 18 Pages: 674-681
- DOI
  10.1111/resp.12072
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390121, KAKENHI-PROJECT-24591460
[Journal Article] Critical role of the IgM Fc receptor in IgM homeostasis, B cell survival, and humoral immune responses2012
- Author(s)
  Ouchida, R., Mori, H., Hase, K., Takatsu, H., Kurosaki, T., Tokuhisa, T., Ohno, H., and Wang, Ji-Yang
- Journal Title
  
  Proc. Natl. Acad. Sci. USA.
  
  Volume: 109 Pages: 2699-2706
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659239
[Journal Article] BAZF, a novel component of cullin3-based E3 ligase complex, mediates VEGFR and Notch cross-signaling in angiogenesis2012
- Author(s)
  Ohnuki H, Inoue H, Takemori N, Nakayama H, Sakaue T, Fukuda S, Miwa D, Nishiwaki E, Hatano M, Tokuhisa T, Endo Y, Nose M, and Higashiyama S
- Journal Title
  
  Blood
  
  Volume: 119 Pages: 2688-2698
- DOI
  10.1182/blood-2011-03-345306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390121, KAKENHI-PROJECT-23659428, KAKENHI-PUBLICLY-23112513
[Journal Article] BAZF, a novel component ofcullin3-based E3 ligase complex, mediates VEGFR and Notch cross-signalling in angiogenesis.2012
- Author(s)
  Ohnuki, H., Inoue, H., Takemori, N., Nakayama, H., Sakaue, T., Fukuda, S., Miwa, D., Nishiwaki, E., Hatano, M., Tokuhisa, T., Endo, Y., Nose, M., and Higashiyama, S.
- Journal Title
  
  Blood
  
  Volume: 119 Pages: 2688-2698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659239
[Journal Article] CD40 amplifies Fas-mediated apoptosis : a mechanism contributing to emphysema2012
- Author(s)
  Shigeta, A., Tada, Y., Wang, J.-Y., Ishizaki, S., Tuyusaki, J., Yamauchi, K., Kasahara, Y., Iesato, K., Tanabe, N., Takiguchi, Y., Sakamoto, A., Tokuhisa, T., Shibuya, K., Hiroshima, K., West, J. and Tatsumi, K.
- Journal Title
  
  American Journal Of Physiology. Lung Cellular And Molecular Physiology
  
  Volume: 303 Pages: 141-151
- DOI
  10.1152/ajplung.00337.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590445, KAKENHI-PROJECT-22590850, KAKENHI-PROJECT-23390121, KAKENHI-PROJECT-23591114, KAKENHI-PROJECT-23591136
[Journal Article] CD40 amplifies Fas-mediated apoptosis: a mechanism contributing to emphysema2012
- Author(s)
  Shigeta, A., Tada, Y., Wang, J.Y., Ishizaki, S., Tsuyusaki, J., Yamauchi, K., Kasahara, Y., Iesato, K., Tanabe, N., Takiguchi, Y., Sakamoto, A., Tokuhisa, T., Shibuya, K., Hiroshima, K., West, J., and Tatsumi, K.
- Journal Title
  
  Am. J. Physiol. Lung Cell Mol. Physiol.
  
  Volume: 303 Pages: 141-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659239
[Journal Article] Critical role of the IgM Fc receptor in IgM homeostasis, B-cell survival, and humoral immune responses.2012
- Author(s)
  Ouchida, R., Mori, H., Hase, K., Takatsu, H., Kurosaki, T., Tokuhisa, T., Ohno, H., Wang. J. -Y.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 109 Pages: 2699-2706
- DOI
  10.1073/pnas.1210706109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12F02784, KAKENHI-PROJECT-21229007, KAKENHI-PROJECT-22590445, KAKENHI-PROJECT-22689017, KAKENHI-PROJECT-23390121, KAKENHI-PLANNED-20113003, KAKENHI-PUBLICLY-24117723
[Journal Article] CXCR4 expression on activated B cells is down-regulated by CD63 and IL-212011
- Author(s)
  Yoshida N, Kitayama D, Arima M, Sakamoto A, Inamine A, Takano H, Hatano M, Koike T, and Tokuhisa T
- Journal Title
  
  J. Immunol
  
  Volume: 186 Pages: 2800-2808
- DOI
  10.4049/jimmunol.1003401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390121
[Journal Article] Bcl6 is required for the development of mouse CD4+ and CD8α+ dendritic cells.2011
- Author(s)
  Ohtsuka, H., Sakamoto, A., Pan, J., Inage, S., Horigome, S., Ichii, H., Arima, M., Hatano, M., Okada, S., Tokuhisa, T.
- Journal Title
  
  J.Immunol. 186
  
  Pages: 255-263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590486
[Journal Article] Over-expression of the LTC(4) synthase gene in mice reproduces human aspirin-induced asthma2011
- Author(s)
  Hirata, H., Arima, M., Fukushima, Y., Honda, K., Sugiyama, K., Tokuhisa, T., and Fukuda, T.
- Journal Title
  
  Clin. Exp. Allergy
  
  Volume: 41 Pages: 1133-1142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659239
[Journal Article] CXCR4 expression on activated B cells is down-regulated by CD63 and IL-212011
- Author(s)
  Yoshida, N., Kitayama, D., Arima, M., Sakamoto, A., Inamine, A., Takano, H., Hatano, M., Koike, T., and Tokuhisa, T
- Journal Title
  
  J. Immunol.
  
  Volume: 186 Pages: 2800-2808
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659239
[Journal Article] Bcl6 is required for the development of mouse CD4^+ and CD8α^+ dendritic cells.2011
- Author(s)
  Ohtsuka H, Sakamoto A, Pan J, Inage S, Horigome S, Ichii H, Arima M, Hatano M, Okada S, Tokuhisa T
- Journal Title
  
  J.Immunol. 186
  
  Pages: 255-263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390139
[Journal Article] CXCR4 expression on activated B cells is down-regulated by CD63 and IL-21.2011
- Author(s)
  Yoshida N, Kitayama D, Arima M, Sakamoto A, Inamine A, Takano H, Hatano M, Koike T, Tokuhisa T
- Journal Title
  
  J.Immunol. 186
  
  Pages: 2800-2808
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390139
[Journal Article] Outcome prediction in sepsis combined use of genetic polymorphisms -A study in Japanese population2011
- Author(s)
  Shimada, T., Oda, S., Sadahiro, T., Nakamura, M., Hirayama, Y., Watanabe, E., Abe, R., Nakada, T.A., Tateishi, Y.,Otani, S., Hirasawa, H., Tokuhisa, T., and Uno, H.
- Journal Title
  
  Cytokine
  
  Volume: 54 Pages: 79-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659239
[Journal Article] Over-expression of the LTC(4) synthase gene in mice reproduces human aspirin-induced asthma2011
- Author(s)
  Hirata H, Arima M, Fukushima Y, Honda K, Sugiyama K, Tokuhisa T, and Fukuda T
- Journal Title
  
  Clin. Exp. Allergy
  
  Volume: 41 Pages: 1133-1142
- DOI
  10.1111/j.1365-2222.2011.03720.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390121
[Journal Article] Bcl6 is required for the development of mouse CD4^+ and CD8α^+ dendritic cells2011
- Author(s)
  Ohtsuka H, Sakamoto A, Pan J, Inage S, Horigome S, Ichii H, Arima M, Hatano M, Okada S, and Tokuhisa T
- Journal Title
  
  J. Immunol
  
  Volume: 186 Pages: 255-263
- DOI
  10.4049/jimmunol.0903714
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390121
[Journal Article] Outcome prediction in sepsis combined use of genetic polymorphisms- A study in Japanese population.2011
- Author(s)
  Shimada T, Oda S, Sadahiro T, Nakamura M, Hirayama Y, Watanabe E, Abe R, Nakada TA, Tateishi Y, Otani S, Hirasawa H, Tokuhisa T, Uno H
- Journal Title
  
  Cytokine 54
  
  Pages: 79-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390139
[Journal Article] CXCR4 expression on activated B cells is down-regulated by CD63 and IL-21.2011
- Author(s)
  Yoshida, N., Kitayama, D., Arima, M., Sakamoto, A., Inamine, A., Takano, H., Hatano, M., Koike, T., Tokuhisa, T.
- Journal Title
  
  J.Immunol. 186
  
  Pages: 2800-2808
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590486
[Journal Article] Bcl6 in pulmonary epithelium coordinately controls the expression of the CC-type chemokine genes and attenuates allergic airway inflammation2011
- Author(s)
  Seto, T., Yoshitake, M., Ogasawara, T., Ikari, J, Sakamoto, A., Hatano, M., Hirata, H., Fukuda, T., Kuriyama, T., Tatsumi, K., Tokuhisa, T., and Arima, M.
- Journal Title
  
  Clin. Exp. Allergy
  
  Volume: 41 Pages: 1568-1578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659239
[Journal Article] Bcl6 is required for the development of mouse CD4^+and DC・^+ dendritic cells.2011
- Author(s)
  Ohtsuka, H., Sakamoto, A., Pan, J., Inage, S., Horigome, S., Ichii, H., Arima, M., Hatano, M., Okada, S., and Tokuhisa, T.
- Journal Title
  
  J. Immunol.
  
  Volume: 186 Pages: 255-263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659239
[Journal Article] Bcl6 in pulmonary epithelium coordinately controls the expression of the CC-type chemokine genes and attenuates allergic airway inflammation airway inflammation2011
- Author(s)
  Seto T, et al
- Journal Title
  
  Clin. Exp. Allergy
  
  Volume: 41 Pages: 1568-1578
- DOI
  10.1111/j.1365-2222.2011.03836.x
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22021010, KAKENHI-PROJECT-23390121, KAKENHI-PROJECT-23659428
[Journal Article] Outcome prediction in sepsis combined use of genetic polymorphisms - A study in Japanese population2011
- Author(s)
  Shimada T, Oda S, Sadahiro T, Nakamura M, Hirayama Y, Watanabe E, Abe R, Nakada TA, Tateishi Y, Otani S, Hirasawa H, Tokuhisa T, and Uno H
- Journal Title
  
  Cytokine
  
  Volume: 54 Pages: 79-84
- DOI
  10.1016/j.cyto.2010.12.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390121
[Journal Article] The proto-oncogene BCL6 promotes survival of olfactory sensory neurons. Dev.2010
- Author(s)
  Otaki JM, Hatano M, Matayoshi R, Tokuhisa T, Yamamoto H
- Journal Title
  
  Neurobiol. 70
  
  Pages: 424-435
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390139
[Journal Article] The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis.2010
- Author(s)
  Miyauchi Y, Ninomiya K, Miyamoto H, Sakamoto A, Iwasaki R, Hoshi H, Miyamoto K, Hao W, Yoshida S, Morioka H, Chiba K, Kato S, Tokuhisa T, Saitou M, Toyama Y, Suda T, Miyamoto T
- Journal Title
  
  J.Exp.Med. 207
  
  Pages: 751-762
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390139
[Journal Article] The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis.2010
- Author(s)
  Miyauchi, Y., Ninomiya, K., Miyamoto, H., Sakamoto, A., Iwasaki, R., Hoshi, H., Miyamoto, K., Hao, W., Yoshida, S., Morioka, H., Chiba, K., Kato, S., Tokuhisa, T., Saitou, M., Toyama, Y., Suda, T., Miyamoto, T.
- Journal Title
  
  J Exp Med. 207
  
  Pages: 751-762
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590486
[Journal Article] Augmented antibody response with premature germinal center regression in CD40L-transgenic mice.2010
- Author(s)
  Kishi Y, Aiba Y, Higuchi T, Furukawa K, Tokuhisa T, Takemori T, Tsubata T
- Journal Title
  
  J.Immunol. 185
  
  Pages: 211-219
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390139
[Journal Article] Clinical application of cytokine-related gene polymorphism analysis using a newly developed DNA chip in critically ill patients.2009
- Author(s)
  Otani S, Oda S, Sadahiro T, Nakamura M, Watanabe E, Abe R, Tokuhisa T, Hirasawa H
- Journal Title
  
  Clin.Biochem. 42
  
  Pages: 1387-1393
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390139
[Journal Article] TBP (TATA-binding protein)-like protein (TLP) is engaged in etoposide-induced apoptosis through transcriptional activation of humanTAp63 Gene.2009
- Author(s)
  Suenaga Y, Ozaki T, Tanaka Y, Bu Y, Kamijo T, Tokuhisa T, Nakagawara A, Tamura TA
- Journal Title
  
  J.Biol.Chem. 284
  
  Pages: 35433-35440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390139
[Journal Article] Prickle promotes neurite outgrowth via the Dishevelled dependent pathway in C1300 cells.2009
- Author(s)
  Fujimura L, Takano H, Sato Y, Tokuhisa T, Hatano M
- Journal Title
  
  Neuroscience Letters 467
  
  Pages: 6-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390139
[Journal Article] A kelch family protein Nd1-L functions as a metastasis suppressor in cancer cells via Rho family proteins mediated mechanism.2009
- Author(s)
  Ohta Y, Fujimura L, Nishio S, Arima M, Sakamoto A, Shimada H, Ochiai T, Tokuhisa T, Hatano M
- Journal Title
  
  Int.J.Oncology 36
  
  Pages: 427-434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390139
[Journal Article] A role for Bcl6 in sequential class switch recombination to IgE in B cells stimulated with IL-4 and IL-212008
- Author(s)
  Kitayama, D., Sakamoto, A., Arima, M., Hatano, M., Miyazaki, M. and Tokuhisa, T.
- Journal Title
  
  Mol. Immunol 45
  
  Pages: 1337-1345
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590467
[Journal Article] A Lysosomal Protein Negatively Regulates Surface T Cell Antigen Receptor Expression by Promoting CD3ζ Degradation.2008
- Author(s)
  Ouchida, R., Yamasaki , S., Hikida, M., Masuda, K., Kawamura, K., Wada, A., Mochizuki, S., Tagawa, M., Sakamoto, A., Hatano, M., Tokuhisa, T., Koseki, H., Saito, T., Kurosaki, T., Wang, J.
- Journal Title
  
  Immunity 29
  
  Pages: 33-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590486
[Journal Article] A role for Bcl6 in sequential class switch recombination to IgE in B cells stimulated with IL-4 and IL-21.2008
- Author(s)
  Kitayama D, Sakamoto A, Arima M, Hatano M, Miyazaki M, Tokuhisa T
- Journal Title
  
  Mol.Immunol. 45
  
  Pages: 1337-1345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390139
[Journal Article] A lysosomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3ζ degradation.2008
- Author(s)
  Ouchida R, Yamasaki S, Hikida M, Masuda K, Kawamura K, Wada A, Mochizuki S, Tagawa, M, Sakamoto A, Hatano M, Tokuhisa T, Koseki H, Saito T, Kurosaki T, Wang Ji-Y
- Journal Title
  
  Immunity 29
  
  Pages: 33-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390139
[Journal Article] Effects of Th2 pulmonary inflammation in mice with bleomycin-induced pulmonary fibrosis.2008
- Author(s)
  Hirata H, Arima M, Fukushima Y, Ishii Y, Tokuhisa T, Fukuda T
- Journal Title
  
  Respirology 13
  
  Pages: 788-798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390139
[Journal Article] A distinct role for IL-4 and IL-21 in their collaboration on proliferation and differentiation of activated B cells2008
- Author(s)
  Saito, T., Kitayama, D., Sakamoto, A., Tsuruoka, N., Arima, M., Hatano, M., Miyazaki, M., and Tokuhisa, T.
- Journal Title
  
  Immunobiol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390149
[Journal Article] Role of the transcriptional repressor BCL6 in allergic response and inflammation.2008
- Author(s)
  Arima M, Fukuda T, Tokuhisa T
- Journal Title
  
  WAO Journal
  
  Pages: 115-122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390139
[Journal Article] Genetic analysis reveals an intrinsic property of the germinal center B cells to generate A : T mutations.2008
- Author(s)
  Ouchida R, Ukai A, Mori H, Kawamura K, Dolle MET, Tagawa M, Sakamoto A, Tokuhisa T, Yokosuka T, Saito T, Yokoi M, Hanaoka F, Vijg J, Wang Ji-Y
- Journal Title
  
  DNA Repair 7
  
  Pages: 1392-1398
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390139
[Journal Article] IL-23 and Th17 cells enhance Th2 cell-mediated eosinophilic airway inflammation in mice.2008
- Author(s)
  Wakashin H, Hirose K, Maezawa Y, Kagami, S-I, Suto A, Watanabe N, Saito Y, Hatano M, Tokuhisa T, Iwakura Y, Puccetti P, Iwamoto I, Nakajima H
- Journal Title
  
  Am.J.Resp.Crit Care Med. 178
  
  Pages: 1023-1032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390139
[Journal Article] A role for Bcl6 in sequential class switch recombination to IgE in B cells stimulated with IL-4 and IL-21.2008
- Author(s)
  Kitayama, D., Sakamoto, A., Arima, M., Hatano, M., Miyazaki, M., Tokuhisa, T.
- Journal Title
  
  Mol.Immunol. 45
  
  Pages: 1337-1345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590486
[Journal Article] A distinct role for IL-4 and IL-21 in their collaboration on proliferation and differentiation of activated B cells.2008
- Author(s)
  Saito T, Kitayama D, Sakamoto A, Tsuruoka N, Arima M, Hatano M, Miyazaki M, Tokuhisa T
- Journal Title
  
  Immunobiol. 213
  
  Pages: 545-555
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390139
[Journal Article] Bcl6 is essential for the generation of long-term memory CD4^+ T cells2007
- Author(s)
  Ichii, H., Sakamoto, A., Arima, M., Hatano, H., Kuroda, Y., and Tokuhisa, T.
- Journal Title
  
  Int. Immunol. 19
  
  Pages: 427-433
- NAID
  10020110313
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390149
[Journal Article] Bc16 is essential for the generation of long-term memory CD4^+ T cells2007
- Author(s)
  Ichii, H., Sakamoto, A., Arima, M., Hatano, H., Kuroda, Y, and Tokuhisa, T.
- Journal Title
  
  Int. Immunol 19
  
  Pages: 427-433
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590467
[Journal Article] Identification of the consensus DNA sequence for Nczf-binding2007
- Author(s)
  Kitahashi, M., Sato, Y, Fujimura, L., Arima, M., Sakamoto, A., Yamamoto, S., Tokuhisa, T., and Hatano, H.
- Journal Title
  
  DNA and Cell Biol. 26
  
  Pages: 395-401
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390149
[Journal Article] A role for Bc16 in sequential class switch recombination to IgE in B cells stimulated with IL-4 and IL-212007
- Author(s)
  Kitayama, D., Sakamoto, A., Arima, M., Hatano, M., Miyazaki, M., and Tokuhisa, T.
- Journal Title
  
  Mol. Immunol. 45
  
  Pages: 1337-1345
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390149
[Journal Article] Bc16 protects apoptosis of naive B cells stimulated with IL-212007
- Author(s)
  Tsuruoka, N., Arima, M., Arguni, E., Saito, T., Kitayama, D., Sakamoto,A., Hatano, M., and Tokuhisa, T.
- Journal Title
  
  Immunol. Lett. 110
  
  Pages: 145-151
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390149
[Journal Article] Role of Clastl in differentiation of cerebellar granule cells2006
- Author(s)
  Maeda, Y, Fujimura, L., O-Wang, J., Hatano, M., Sakamoto,A., Arima, M., Ebara, M., Ino, H., Yamashita, T., Saisho, H., and Tokuhisa, T.
- Journal Title
  
  Brain Res. 1104
  
  Pages: 18-26
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390149
[Journal Article] JunD/AP-1 and STAT3 are the major enhancer molecules for high Bcl6 expression in germinal center B cells2006
- Author(s)
  Arguni, E., Arima, M., Tsuruoka, N., Sakamoto, A., Hatano, M., and Tokuhisa, T.
- Journal Title
  
  Int. Immunol 18
  
  Pages: 1079-89
- NAID
  10020617885
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590467
[Journal Article] Bc16 controls Granzyme B expression in effector CD8 T cells2006
- Author(s)
  Yoshida, K., Sakamoto, A., Yamashita, K., Arguni, E., Horigome, S., Arima, M., Hatano, M., Seki, N., Ichikawa, T., and Tokuhisa, T.
- Journal Title
  
  Eur. J. Immunol. 36
  
  Pages: 3146-3156
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390149
[Journal Article] JunD/AP-1 and STAT3 are the major enhancer molecules for high Bc16 expression in germinal center B cells2006
- Author(s)
  Arguni, E., Arima, M., Tsuruoka, N., Sakamoto, A., Hatano, M., and Tokuhisa, T.
- Journal Title
  
  Int. Immunol. 18
  
  Pages: 1079-1089
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390149
[Journal Article] Lung-specific expression of IL-25 enhances allergic airway inflammation by amplifying a Th2 cell-dependent pathway2006
- Author(s)
  Tamachi, T., Maezawa, Y., Ikeda, K., Kagami, S., Hatano, M., Seto, Y., Suto, A., Suzuki, K., Watanabe, N., Saito, Y., Tokuhisa, T., Iwamoto, I., and Nakajima, H.
- Journal Title
  
  J. Allergy Clin. Immunol. 118
  
  Pages: 606-614
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390149
[Journal Article] Expression of the Ndl gene is down-regulated by doxorubicin at post-transcriptional level2006
- Author(s)
  Takamori, Y., Matsudo, Y., Fujimura, L., Kang, M., Harada, Y, Moriya, H., Tokuhisa, T., and Hatano, M.
- Journal Title
  
  Int. J. Mol. Med. 18
  
  Pages: 963-967
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390149
[Journal Article] Bc16 controls granzyme B expression in effector CD8+ T cells2006
- Author(s)
  Yoshida, K., Sakamoto, A., Yamashita, K., Arguni, E., Horigome, S., Arima, M., Hatano, M., Seki, N., Ichikawa, T., and Tokuhisa, T.
- Journal Title
  
  Eur. J. Immunol 36
  
  Pages: 3146-56
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590467
[Journal Article] Overexpression of Ndl, a novel Kelch family protein, in the heart of transgenic mice protects against doxorubicin-induced cardiomyopathy2006
- Author(s)
  Matsudo, Y., Takamori, Y., Sasagawa, K., Fujimura, L., Komuro, I., Tokuhisa, T., and Hatano, M.
- Journal Title
  
  Transgenic Research 15
  
  Pages: 573-581
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390149
[Journal Article] Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through induction ofP53 and activation of JNK.2005
- Author(s)
  Nishio, S., Hatano, M., Nagata, M., Horie, S., Koike, T., Tokuhisa, T., Mochizuki, T.
- Journal Title
  
  J.Clin.Invest. 115
  
  Pages: 910-918
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590240
[Journal Article] A role for c-Fos/AP-1 in B lymphocyte terminal differentiation.2005
- Author(s)
  Ohkubo, Y, Arima, M., Arguni, E., Okada, S., Yamashita, K., Asari, S., Obata, S., Sakamoto, A., Hatano, M., O-Wang, J., Ebara, M., Saisho, H., Tokuhisa, T.
- Journal Title
  
  J.Immunol. 174
  
  Pages: 7703-7710
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616001
[Journal Article] Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through induction of P53 and activation of JNK.2005
- Author(s)
  Nishio, S., Hatano, M., Nagata, M., Horie, S., Koike, T., Tokuhisa, T., Mochizuki, T.
- Journal Title
  
  J.Clin.Invest. 115
  
  Pages: 910-918
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390140
[Journal Article] Overexpression of Nd1-S, a variant form of new kelch family protein, perturbs the cell cycle progression of fibroblasts.2005
- Author(s)
  Inoue, A., Kang, M., Fujimura, L., Takamori, Y., Sasagawa, K., Itoh, H., Tokuhisa, T., Hatano, M.
- Journal Title
  
  DNA Cell Biol. 24
  
  Pages: 30-34
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590240
[Journal Article] Abnormal erythroid differentiation in neonatal Bcl6-deficient mice.2005
- Author(s)
  Asari, S., Sakamoto, A., Okada, S., Ohkubo, Y., Arima, M., Hatano, M., Kuroda, K., Tokuhisa, T.
- Journal Title
  
  Exp.Hematol. 33
  
  Pages: 26-34
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616001
[Journal Article] DNA polymerase (theta) contributes to the generation of C/G mutations during somatic hypermutation of Ig genes.2005
- Author(s)
  Masuda, K., Ouchida, R., Takeuchi, A., Saito, T., Koseki, H., Kawamura, K., Tagawa, M., Tokuhisa, T., Azuma, T., Jiyang O-Wang, J.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 102
  
  Pages: 13986-13991
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390140
[Journal Article] Targeted disruption of TGF-β-Smad3 signaling leads to enhanced neointimal hyperplasia with diminished matrix deposition in response to vascular injury.2005
- Author(s)
  Kobayashi, K., Yokote, K., Fujimoto, M., Yamashita, K., Sakamoto, A., Kitahara, M., Kawamura, H., Maezawa, Y, Asaumi, S., Tokuhisa, T., Mori, S., Saito, Y.
- Journal Title
  
  Circ.Res. 96
  
  Pages: 904-912
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616001
[Journal Article] A role for c-Fos/AP-1 in B lymphocyte terminal differentiation.2005
- Author(s)
  Ohkubo, Y., Arima, M., Arguni, E., Okada, S., Yamashita, K., Asari, S., Obata, S., Sakamoto, A., Hatano, M., O-Wang, J., Ebara, M., Saisho, H., Tokuhisa, T.
- Journal Title
  
  J.Immunol. 174
  
  Pages: 7703-7710
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390140
[Journal Article] A role for c-Fos/AP-1 in B lymphocyte terminal differentiation.2005
- Author(s)
  Ohkubo, Y., Arima, M., Arguni, E., Okada, S., Yamashita, K., Asari, S., Obata, S., Sakamoto, A., Hatano, M., O-Wang, J., Ebara, M., Saisho, H., Tokuhisa, T.
- Journal Title
  
  J.Immunol. 174
  
  Pages: 7703-7710
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590240
[Journal Article] β-galactosidase of ROSA26 mice is a useful marker for detecting the definitive erythropoiesis after stem cell transplantation.2004
- Author(s)
  Asari, S., Okada, S., Ohkubo, Y., Sakamoto, A., Arima, M., Hatano, M., Kuroda, Y., Tokuhisa, T.
- Journal Title
  
  Transplantation 78
  
  Pages: 516-523
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616001
[Journal Article] Impaired lymphocyte development and function in Clast5/Stra13/DEC1 transgenic mice.2004
- Author(s)
  Seimiya, M., Wada, A., Kawamura, K., Sakamoto, A., Ohkubo, Y., Okada, S., Hatano, M., Tokuhisa, T., Watanabe, T., Saisho, H., Tagawa, M., O-Wang, J.
- Journal Title
  
  Eur.J.Immunol. 34
  
  Pages: 1322-1332
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616001
[Journal Article] Bcl6 acts as an amplifier for the generation and proliferative capacity of central memory CD8^+ T cells.2004
- Author(s)
  Ichii, H., Sakamoto, A., Kuroda, Y., Tokuhisa, T.
- Journal Title
  
  J.Immunol. 173
  
  Pages: 883-891
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616001
[Journal Article] Role of autophagy during the early neonatal starvation period.2004
- Author(s)
  Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., Mizushima, N.
- Journal Title
  
  Nature 432
  
  Pages: 1032-1036
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590240
[Journal Article] Bcl6 acts as an amplifier for the generation and proliferative capacity of central memory CD8^+ T cells.2004
- Author(s)
  Ichii, H., Sakamoto, A., Kuroda, Y., Tokuhisa T.
- Journal Title
  
  J.Immunol. 173
  
  Pages: 883-891
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390140
[Journal Article] Protective role of Nd1 in doxorubicin-induced cardiotoxicity.2004
- Author(s)
  Fujimura, L., Matsudo, Y., Kang, M., Takamori, Y., Tokuhisa, T., Hatano, M.
- Journal Title
  
  Cardiovasc.Res. 64
  
  Pages: 315-321
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590240
[Journal Article] Abnormal erythroid differentiation in neonatal Bcl6-deficient mice.2004
- Author(s)
  Asari, S., Sakamoto, A., Okada, S., Ohkubo, Y, Arima, M., Hatano, M., Kuroda, K., Tokuhisa, T.
- Journal Title
  
  Transplantation 78
  
  Pages: 516-523
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390140
[Journal Article] Role of autophagy during the early neonatal starvation period.2004
- Author(s)
  Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., Mizushima, N.
- Journal Title
  
  Nature 432
  
  Pages: 1032-1036
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390140
[Presentation] 免疫記憶細胞の形成と維持2014
- Author(s)
  徳久剛史
- Organizer
  東京免疫フォーラム
- Place of Presentation
  東京
- Year and Date
  2014-02-24
- Data Source
  KAKENHI-PROJECT-23390121
[Presentation] α2-antiplasmin/PAI-1両遺伝子欠損マウスにおける免疫系の変化についての検討.2014
- Author(s)
  上嶋繁, 岡田清孝, 河尾直之, 矢野昌人, 田村行識, 田中勝喜, 坂本明美, 幡野雅彦, 有馬雅史, 宮田清司, 永井信夫, 徳久剛史, 松尾理
- Organizer
  日本血栓止血学会
- Place of Presentation
  大阪国際交流センター (大阪府大阪市）
- Year and Date
  2014-05-30
- Data Source
  KAKENHI-PROJECT-24591460
[Presentation] 免疫記憶細胞の形成と維持2014
- Author(s)
  徳久剛史
- Organizer
  東京免疫フォーラム
- Place of Presentation
  東京大学医科学研究所（東京都）
- Invited
- Data Source
  KAKENHI-PROJECT-23390121
[Presentation] 粘液記憶細胞の形成と維持2014
- Author(s)
  徳久剛史
- Organizer
  東京免疫フォーラム
- Place of Presentation
  東京大学医科学研究（東京）
- Invited
- Data Source
  KAKENHI-PROJECT-25670227
[Presentation] Development of High Affinity IgE B Cells2013
- Author(s)
  Tokuhisa T
- Organizer
  Chiba and Auckland University Immunology Forum
- Place of Presentation
  New Zealand
- Year and Date
  2013-02-23
- Data Source
  KAKENHI-PROJECT-23390121
[Presentation] IgE 抗体産生機構と制御法の開発2013
- Author(s)
  徳久剛史, 有馬雅史
- Organizer
  第25回日本アレルギー学会
- Place of Presentation
  横浜
- Year and Date
  2013-05-12
- Data Source
  KAKENHI-PROJECT-23390121
[Presentation] 免疫記憶細胞の形成と維持2012
- Author(s)
  徳久剛史
- Organizer
  市川免疫研究会
- Place of Presentation
  市川市
- Year and Date
  2012-06-27
- Data Source
  KAKENHI-PROJECT-23659239
[Presentation] 若き臨床研究者たちへ2012
- Author(s)
  徳久剛史
- Organizer
  第51回日本鼻科学会特別講演
- Place of Presentation
  千葉市
- Year and Date
  2012-09-28
- Data Source
  KAKENHI-PROJECT-23659239
[Presentation] 若き臨床研究者たちへ2012
- Author(s)
  徳久剛史
- Organizer
  第51回日本鼻科学会
- Place of Presentation
  幕張メッセ
- Year and Date
  2012-09-28
- Data Source
  KAKENHI-PROJECT-23390121
[Presentation] 将来構想に基づく博士課程教育リーディングプログラム2012
- Author(s)
  徳久剛史
- Organizer
  神戸大G-COEセミナー
- Place of Presentation
  神戸市
- Year and Date
  2012-10-17
- Data Source
  KAKENHI-PROJECT-23659239
[Presentation] 免疫記憶細胞の形成と維持2012
- Author(s)
  徳久剛史
- Organizer
  第40回日本臨床免疫学会教育講演
- Place of Presentation
  東京
- Year and Date
  2012-09-29
- Data Source
  KAKENHI-PROJECT-23659239
[Presentation] アレルギーは治せるか2012
- Author(s)
  徳久剛史
- Organizer
  松戸東病院セミナー
- Place of Presentation
  松戸市
- Year and Date
  2012-11-16
- Data Source
  KAKENHI-PROJECT-23659239
[Presentation] 免疫記憶細胞の形成と維持2012
- Author(s)
  徳久剛史
- Organizer
  第40回日本臨床免疫学会
- Place of Presentation
  東京
- Year and Date
  2012-09-29
- Data Source
  KAKENHI-PROJECT-23390121
[Presentation] 免疫記憶と慢性アレルギー2012
- Author(s)
  徳久剛史
- Organizer
  第6回日本アミノ酸学会特別講演
- Place of Presentation
  松戸市
- Year and Date
  2012-09-28
- Data Source
  KAKENHI-PROJECT-23659239
[Presentation] 免疫記憶と慢性アレルギー2012
- Author(s)
  徳久剛史
- Organizer
  第6回日本アミノ酸学会
- Place of Presentation
  松戸市
- Year and Date
  2012-09-28
- Data Source
  KAKENHI-PROJECT-23390121
[Presentation] B cell activation and memory2011
- Author(s)
  Tokuhisa T.
- Organizer
  第40回日本免疫学会シンポジウム
- Place of Presentation
  千葉市
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-23659239
[Presentation] B cell activation and memory2011
- Author(s)
  Tokuhisa, T.
- Organizer
  日本免疫学会
- Place of Presentation
  幕張メッセ(千葉市)(招待講演)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-23390121
[Presentation] B cell activation and memory2011
- Author(s)
  Tokuhisa T.
- Organizer
  第40回日本免疫学会シンポジウム
- Place of Presentation
  千葉市
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-23659239
[Presentation] 老化すると免疫記憶にもボケがでるか2011
- Author(s)
  徳久剛史
- Organizer
  第11回日本抗加齢医学会「加齢と免疫」シンポジウム
- Place of Presentation
  京都
- Year and Date
  2011-05-28
- Data Source
  KAKENHI-PROJECT-23390121
[Presentation] A Role of Bcl6 in the generation and maintenance of follicular helper T cells.2010
- Author(s)
  Sakamoto A, Pan J, Kohno M, Arima M, Hatano M, Tokuhisa T.
- Organizer
  14^<th> International congress of Immunology
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590486
[Presentation] アレルギーは治せるか2010
- Author(s)
  徳久剛史
- Organizer
  千葉大経済人クラブ
- Place of Presentation
  浦安
- Year and Date
  2010-10-04
- Data Source
  KAKENHI-PROJECT-20390139
[Presentation] Role for Bcl6 in Differentiation of High Affinity IgE B Cells2010
- Author(s)
  徳久剛史
- Organizer
  5th G-COE symposium.
- Place of Presentation
  Tokyo
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-20390139
[Presentation] 高親和性IgE抗体産生細胞の分化とヘルパーT細胞の多様性2010
- Author(s)
  徳久剛史、有馬雅史
- Organizer
  第60回日本アレルギー学会
- Place of Presentation
  東京
- Year and Date
  2010-11-26
- Data Source
  KAKENHI-PROJECT-20390139
[Presentation] 高親和性IgE抗体産生細胞の分化とヘルパーT細胞の多様性2010
- Author(s)
  徳久剛史、有馬雅史
- Organizer
  第60回日本アレルギー学会
- Place of Presentation
  東京
- Year and Date
  2010-11-26
- Data Source
  KAKENHI-PROJECT-21659243
[Presentation] Roles for Bcl6 in differentiation of germinal center B cells2010
- Author(s)
  徳久剛史
- Organizer
  4th G-COE symposium.
- Place of Presentation
  Chiba
- Year and Date
  2010-08-20
- Data Source
  KAKENHI-PROJECT-20390139
[Presentation] 研究指導者に望まれる資質2010
- Author(s)
  徳久剛史
- Organizer
  G-COEリトリート
- Place of Presentation
  千葉
- Year and Date
  2010-09-05
- Data Source
  KAKENHI-PROJECT-20390139
[Presentation] 高親和性IgE抗体産生細胞の分化とヘルパーT細胞の多様性2010
- Author(s)
  徳久剛史
- Organizer
  第60回日本アレルギー学会
- Place of Presentation
  東京(特別講演)
- Year and Date
  2010-11-26
- Data Source
  KAKENHI-PROJECT-20390139
[Presentation] 部局の活性化にむけて2010
- Author(s)
  徳久剛史
- Organizer
  創立60周年記念大学改革シンポジウム
- Place of Presentation
  千葉
- Year and Date
  2010-01-25
- Data Source
  KAKENHI-PROJECT-20390139
[Presentation] Role of Bcl6 in the generation and maintenance of follicular helper T cells.2009
- Author(s)
  Sakamoto A, Pan J, Mochiduki A, Kohno M, Arima M, Hatano M, Tokuhisa T.
- Organizer
  第39回日本免疫学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590486
[Presentation] Possible roles for Bcl6 in differentiation of Germinal Center B cells2009
- Author(s)
  徳久剛史
- Organizer
  1st G-COE symposium.
- Place of Presentation
  Tokyo
- Year and Date
  2009-01-06
- Data Source
  KAKENHI-PROJECT-20390139
[Presentation] IgE抗体の産生機構2009
- Author(s)
  徳久剛史
- Organizer
  第17回関東アレルギークラブ
- Place of Presentation
  東京都
- Year and Date
  2009-03-07
- Data Source
  KAKENHI-PROJECT-20060004
[Presentation] Role for Bcl6 in development and maintenance of germinal center B cells2009
- Author(s)
  徳久剛史
- Organizer
  RISP2009 Lecture
- Place of Presentation
  Yokohama
- Year and Date
  2009-07-06
- Data Source
  KAKENHI-PROJECT-20390139
[Presentation] Role for Bcl6 in development and maintenance of germinal center B cells2009
- Author(s)
  徳久剛史
- Organizer
  LAH 50th Symposium
- Place of Presentation
  Stanford, USA
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-20390139
[Presentation] Role for Bc16 in development and maintenance of germinal center B cells2009
- Author(s)
  Tokuhisa, T.
- Organizer
  LAH 50th Memorial Symposium
- Place of Presentation
  米国カリフォルニア州スタンフォード市
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-20390139
[Presentation] IgE抗体の産生機構2009
- Author(s)
  徳久剛史
- Organizer
  第17回関東アレルギークラブ
- Place of Presentation
  東京都
- Year and Date
  2009-03-07
- Data Source
  KAKENHI-PROJECT-20390139
[Presentation] Role for Bcl6 in development and maintenance of germinal center B cells2009
- Author(s)
  Tokuhisa, T.
- Organizer
  LAH 50th Memorial Symposium
- Place of Presentation
  米国カリフォルニア州スタンフォード市
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-21659243
[Presentation] 抗体の威力2009
- Author(s)
  徳久剛史
- Organizer
  免疫ふしぎ未来2009免疫シンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-05-02
- Data Source
  KAKENHI-PROJECT-20390139
[Presentation] Role for Bcl6 in development and maintenance of germinal center B cells2009
- Author(s)
  Tokuhisa, T.
- Organizer
  LAH 50th Memorial Symposium
- Place of Presentation
  米国カリフォルニア州スタンフォード市
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-20060004
[Presentation] IgE抗体の産生機2009
- Author(s)
  徳久剛史
- Organizer
  第17回関東アレルギークラブ
- Place of Presentation
  東京(特別講演)
- Year and Date
  2009-03-07
- Data Source
  KAKENHI-PROJECT-20390139
[Presentation] Role of Bcl6 in the generation of follicular helper T cells.2008
- Author(s)
  Sakamoto A, Arima M, Hatano M, Tokuhisa T.
- Organizer
  第38回日本免疫学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590486
[Presentation] Self-Tolerance in Germinal Center B cells2008
- Author(s)
  徳久剛史
- Organizer
  Immunological Self-Recognition and Its Disorders.
- Place of Presentation
  Kyoto
- Year and Date
  2008-07-03
- Data Source
  KAKENHI-PROJECT-20390139
[Presentation] 医学部における寄生虫学教育2008
- Author(s)
  徳久剛史
- Organizer
  第77回日本寄生虫学会シンポジウム
- Place of Presentation
  長崎
- Year and Date
  2008-04-03
- Data Source
  KAKENHI-PROJECT-20390139
[Presentation] A Role for Bc16 in B Cells Activated with Sequential Stimulation of IL-4 and IL-212008
- Author(s)
  徳久剛史、他
- Organizer
  第36回日本免疫学会
- Place of Presentation
  大阪
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390149
[Presentation] Bc16 protects apoptosis of naive B cells stimulated with IL-212007
- Author(s)
  Tsuruoka, N., Tokuhisa, T., et. al.
- Organizer
  37h Japanese Society for Immunology
- Place of Presentation
  Tokyo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390149
[Presentation] A Role for Bcl6 in B Cells Activated with Sequential Stimulation of IL-4 and IL-212006
- Author(s)
  Tokuhisa, T., Kitayama, D., Tsuruoka, N., Saito, T., Sakamoto,A., Arima, M., and Hatano, M.
- Organizer
  36th Japanese Society for Immunology
- Place of Presentation
  Osaka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390149
[Presentation] 免疫記憶細胞の形成と維持
- Author(s)
  徳久剛史
- Organizer
  日本臨床免疫学会
- Place of Presentation
  京王プラザホテル（東京都）
- Invited
- Data Source
  KAKENHI-PROJECT-23390121
[Presentation] 免疫記憶細胞の形成と維持
- Author(s)
  徳久剛史
- Organizer
  日本臨床免疫学会
- Place of Presentation
  京王プラザホテル（東京都）
- Invited
- Data Source
  KAKENHI-PROJECT-23659239
[Presentation] 肝臓における薬物代謝の性差を制御する新規分子の探索
- Author(s)
  紙谷　聡英、近田裕美、井田絹代、坂本明美、徳久剛史.
- Organizer
  第8回日本性差医学・医療学会学術集会
- Place of Presentation
  ホテルクレメント徳島（徳島県・徳島市）
- Year and Date
  2015-01-31 – 2015-02-01
- Data Source
  KAKENHI-PROJECT-24590573
[Presentation] B cell activation and memory
- Author(s)
  Tokuhisa, T.
- Organizer
  日本免疫学会(招待講演)
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-23659239
[Presentation] IgE抗体産生機構と制御法の開発
- Author(s)
  徳久剛史、有馬雅史
- Organizer
  第25回日本アレルギー学会春季臨床大会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24591460
[Presentation] Role of enteric neurons in regulation of intestinal epithelial homeostasis.
- Author(s)
  Fujimura L, Ohara Y, Arima M, Sakamoto A, Tokuhisa T, Hatano M.
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  国立京都国際会館（京都府・京都市）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24590573
[Presentation] 肝臓における薬物代謝の性差を制御する新規分子の探索
- Author(s)
  紙谷　聡英、近田裕美、井田絹代、坂本明美、徳久剛史.
- Organizer
  第8回日本性差医学・医療学会学術集会
- Place of Presentation
  ホテルクレメント徳島（徳島）
- Year and Date
  2015-01-31 – 2015-02-01
- Data Source
  KAKENHI-PROJECT-25670227
[Presentation] Role of enteric neurons in regulation of intestinal epithelial homeostasis.
- Author(s)
  Fujimura L, Ohara Y, Arima M, Sakamoto A, Tokuhisa T, Hatano M.
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  京都国際会議場（京都）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25670227

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TOKUHISA Takeshi 徳久 剛史

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Heterogeneity of naive CD4 T cellsPrincipal Investigator

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Molecular mechanisms of memory B cell differentiation in germinal centersPrincipal Investigator

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A role of ADAR1 in induction of somatic hypermutationPrincipal Investigator

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アレルギー性炎症におけるPHF11ファミリーの機能解析と新規治療法の開発Principal Investigator

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胚中心における末梢性自己免疫寛容誘導機序Principal Investigator

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Survival mechanism of memory B cellsPrincipal Investigator

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細胞寿命に関する転写因子レベルでの研究Principal Investigator

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A role of Bcl6 in regulation of somatic hypermutation in the immunoglobulin genePrincipal Investigator

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TOKUHISA Takeshi 徳久剛史