OHNISHI Kazuo 大西和夫

… Alternative Names

大西和夫オオニシカズオ

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Researcher Number	90169011
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2015 – 2017: 国立感染症研究所, 免疫部, 主任研究官 2013: 国立感染症研究所, 免疫部, 主任研究員 2010 – 2011: 国立感染症研究所, 免疫部, 主任研究員 2002 – 2005: 国立感染症研究所, 免疫部, 主任研究官 1997: 感染研, 研究員 … More 1996: 国立予防衛生研究所, 免疫部, 研究員 1991: NIH, Dep. Cell. Immunol., Researcher, 細胞免疫部, 研究員 1990: 国立予防衛生研究所, 細胞免疫部, 研究官 Less
Review Section/Research Field	Principal Investigator Immunology / Immunology Except Principal Investigator Biological Sciences / Morphological basic dentistry / Immunology
Keywords	Principal Investigator プレB細胞受容体 / 代替軽鎖 / B細胞分化 / μ鎖分子複合体 / アッセンブリ / 小胞体 / シグナル伝達 / 分化シグナル / クローニング / Bリンパ球分化 … More / 抗体産生機構 / 粘膜免疫 / 細胞接着分子 / リンパ球動態制御 / カドヘリン / 感染の分子機構 / プレB細胞レセプター / リンパ球ホーミング / B-lymphocyte developmet / Antibody production / Mucosal immunity / Adhesion molecule / Lymphocyte translocation / Cadherin / Molecular mechanism of infection / PreB cell receptor / 抗体レパトア全体像 / 抗体レパトア発生機構 / 自己抗原反応レパトア / 抗原応答抗体予測 / 抗体遺伝子合成 / 抗原抗体反応測定 / VDJ遺伝子再構成制御 / 次世代シークエンサー / 次世代シークエンサ / 抗体レパトア / 抗体応答 / VDJ遺伝子再構成 / 立体構造モデリング / 体細胞突然変異 … More Except Principal Investigator V_H gene replacement / circular DNA / 幼若造血細胞株 / 分化 / 胎児胸腺 / マクロファ-ジ / マスト細胞 / 幼若造血細胞特異的単クロ-ン抗体 / 造血細胞表面抗原 / Abelson マウス白血病ウィルス / SARSコロナウイルス / 不活化ワクチン / 免疫応答 / UV照射不活化ワクチン / 口腔解剖学（含組織学・発生学） / 歯髄 / 血管 / トロンボポエチン / 歯胚 / TPO / vegfr / 歯　胚 / 歯　髄 / c-Mpl / 幼若B細胞特異的遺伝子 / Ig gene superfamily / B細胞成熟 / μ鎖発現 / μ鎖輸送 / トランスジェニックマウス / CD45R / Macー1陽性細胞 / シグナル伝達 / μ鎖複合体 / 前B細胞 / virgin B細胞 / B cell maturation / mu chain expression / B cell specific gene / surrogate L chains / lg gene super family / mu chain transport Less

Explicit representation of holistic antibody repertoire by exhaustive RNA sequencing and the antibody expression by reverse genetics.Principal Investigator
- Principal Investigator
  
  OHNISHI Kazuo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  National Institute of Infectious Diseases
Spatiotemporal analysis of a TPO signal control mechanism and examination of clinical application in pulp chamber high order blood vessel construction
- Principal Investigator
  
  SUNOHARA Masataka
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  The Nippon Dental University
SARS-coronavirusワクチン開発に関する基礎研究
- Principal Investigator
  
  横田恭子
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Infectious Diseases
Studies on the freme-work of mucosal immunity by the functional analysis of novel cadherin family moleculePrincipal Investigator
- Principal Investigator
  
  OHNISHI Kazuo
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  National Institute of Infectious Diseases
u鎖分子複合体のアッセンブリとシグナル伝達関連因子のクローニングPrincipal Investigator
- Principal Investigator
  
  大西和夫
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  国立予防衛生研究所
胎児胸腺由来幼若造血細胞株の確立とその多能性分化能の解析
- Principal Investigator
  
  TAKEMORI Toshitada
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  国立予防衛生研究所
The analysis of B cell differentiation and maturation
- Principal Investigator
  
  TAKEMORI Toshitada
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  National Institute of Health

All 2018 2017 2016 2015 2006 2005 2004 2003 2002

All Journal Article Presentation Book

[Book] リンパ球分化(免疫学ハンドブック/第2部「免疫の分子機構」の一部)2005
- Author(s)
  大西和夫
- Total Pages
  470
- Publisher
  オーム社(2005年9月刊行予定)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570290
[Journal Article] Deciphering antigen-responding antibody repertoires by using next-generation sequencing and confirming them through antibody-gene synthesis2018
- Author(s)
  Lin Sun, Naoko Kono, Takeyuki Shimizu, Hiroyuki Toh, Hanbing Xue, Osamu Numata, Manabu Ato, Shigeyuki Itamura, Kazuo Ohnishi
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 495 Pages: 1411-1417
- DOI
  10.1016/j.bbrc.2017.11.171
- NAID
  120007134450
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15159
[Journal Article] Severe acute respiratory syndrome (SARS) coronavirus : application of monoclonal antibodies and for the development of an effective vaccine.2006
- Author(s)
  Tsunetsugu-Yokota, Y., Ohnishi, K., Takemori, T.
- Journal Title
  
  Rev.Med.Virol. 16
  
  Pages: 117-131
- Data Source
  KAKENHI-PROJECT-16017314
[Journal Article] Lymphocyte-expressed BILL-cadherin/cadherin-17 contributes to the development of B cells at two stages2005
- Author(s)
  Kazuo Ohnishi, et al.
- Journal Title
  
  Eur.J.Immunol. 35(3)
  
  Pages: 957-963
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570290
[Journal Article] Immunological detection of serve acute respiratory syndrome coronavirus by monoclonal antibodies.2005
- Author(s)
  Ohnishi, K., et al.
- Journal Title
  
  Jp.J.Infect.Dis. 58
  
  Pages: 88-94
- Data Source
  KAKENHI-PROJECT-16017314
[Journal Article] Immunological detection of severe acute respiratory syndrome coronavirus by monoclonal antibodies.2005
- Author(s)
  Ohnishi, K., et al.
- Journal Title
  
  JJID. (in press)
- NAID
  40006702872
- Data Source
  KAKENHI-PROJECT-16017314
[Journal Article] How preBCR signal is generated2004
- Author(s)
  Kazuo Ohnishi
- Journal Title
  
  Rinsho-meneki 41(6)
  
  Pages: 629-637
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570290
[Journal Article] PreBCRシグナルはいかにして用意されるか2004
- Author(s)
  大西和夫
- Journal Title
  
  臨床免疫 41(6)
  
  Pages: 629-637
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570290
[Journal Article] The nonimmunoglobulin portion of λ5 mediates cell-autonomous pre-B cell receptor signaling.2003
- Author(s)
  Kazuo Ohnishi, et al.
- Journal Title
  
  Nature Immunol. 4(9)
  
  Pages: 849-856
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570290
[Journal Article] The functional roles of preB-cell receptor2002
- Author(s)
  Kazuo Ohnishi
- Journal Title
  
  Rinsho-meneki 38(6)
  
  Pages: 640-647
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570290
[Journal Article] プレB細胞レセプターの役割とその機序2002
- Author(s)
  大西和夫
- Journal Title
  
  臨床免疫 38(6)
  
  Pages: 640-647
- NAID
  40005620685
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570290
[Presentation] Examination of “Universal Light Chain” models that can be paired with a wide spectrum of immunoglobulin heavy chains maintaining their antigen-binding specificities2017
- Author(s)
  薛漢兵、孫琳、大西和夫
- Organizer
  第４６回日本免疫学会
- Data Source
  KAKENHI-PROJECT-15K15159
[Presentation] 代替L鎖の分子系統解析2016
- Author(s)
  藤　博幸, 大西和夫
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-15K15159
[Presentation] Designing of 'Universal Light-Chain' that might be able to associate with a wide spectrum of heavy-chains maintaining their antigen-binding specificity2016
- Author(s)
  XUE Hanbing, SUN Lin, OHNISHI Kazuo
- Organizer
  The 45th Annual Meeting of Japanese Society for Immunology
- Place of Presentation
  Okinawa Convention Center
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K15159
[Presentation] 代替L鎖の分子系統解析2016
- Author(s)
  藤　博幸、大西　和夫
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場(福岡市)
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-15K15159
[Presentation] Next Generation Sequencer Analysis of B cell Repertoires in λ5-deficient mice2016
- Author(s)
  SUN Lin, OHNISHI Kazuo
- Organizer
  The 45th Annual Meeting of Japanese Society for Immunology
- Place of Presentation
  Okinawa Convention Center
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K15159
[Presentation] Generation of Amino Acid Indices to Distinguish Two Peptide Groups2016
- Author(s)
  Miyaki, R., Toh H., Ohnishi, K.
- Organizer
  CBI学会2016年大会
- Place of Presentation
  タワーホール船堀
- Year and Date
  2016-10-25
- Data Source
  KAKENHI-PROJECT-15K15159
[Presentation] Search for a "Universal-IgL" that is able to associate with wide range of IgH species and the optimization of NGS-predicted antibody synthesis2015
- Author(s)
  SUN Lin, KONO Naoko, SHIMIZU Takeyuki, OHNISHI Kazuo
- Organizer
  第４４回日本免疫学会
- Place of Presentation
  札幌コンベンションセンター（札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K15159
[Presentation] Deep Sequence Landscape of Antibody Repertoire and its Antigen Responding Dynamics of Individual Mice Analyzed by Next Generation Sequencer (NGS)2015
- Author(s)
  KONO Naoko, XUE Hanbing, SUN Lin, SHIMIZU Takeyuki, OHNISHI Kazuo
- Organizer
  第４４回日本免疫学会
- Place of Presentation
  札幌コンベンションセンター（札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K15159

1. TAKEMORI Toshitada (60114295)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. 重本和宏 (00192104)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SUNOHARA Masataka (70287770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. TOKUHISA Takeshi (20134364)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MIZUGUCHI Junichiro (20150188)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KIMOTO Hiroshi (20225080)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 谷山忠義 (20136609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 横田恭子 (20182701)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 高橋宣聖 (60311403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 大島正道 (10272428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 藤猪英樹 (50356250)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 高須賀直美 (70203297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 藤博幸 (70192656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
14. 野口保 (00357740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 藤本浩文 (60373396)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OHNISHI Kazuo 大西 和夫

大西 和夫 オオニシ カズオ

Research Projects

Research Products

Co-Researchers

Explicit representation of holistic antibody repertoire by exhaustive RNA sequencing and the antibody expression by reverse genetics.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Spatiotemporal analysis of a TPO signal control mechanism and examination of clinical application in pulp chamber high order blood vessel construction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

SARS-coronavirusワクチン開発に関する基礎研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on the freme-work of mucosal immunity by the functional analysis of novel cadherin family moleculePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

u鎖分子複合体のアッセンブリとシグナル伝達関連因子のクローニングPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

胎児胸腺由来幼若造血細胞株の確立とその多能性分化能の解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

The analysis of B cell differentiation and maturation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] リンパ球分化(免疫学ハンドブック/第2部「免疫の分子機構」の一部)2005

Author(s)

Total Pages

Publisher

Description

Data Source

[Journal Article] Deciphering antigen-responding antibody repertoires by using next-generation sequencing and confirming them through antibody-gene synthesis2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Severe acute respiratory syndrome (SARS) coronavirus : application of monoclonal antibodies and for the development of an effective vaccine.2006

Author(s)

Journal Title

Data Source

[Journal Article] Lymphocyte-expressed BILL-cadherin/cadherin-17 contributes to the development of B cells at two stages2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Immunological detection of serve acute respiratory syndrome coronavirus by monoclonal antibodies.2005

Author(s)

Journal Title

Data Source

[Journal Article] Immunological detection of severe acute respiratory syndrome coronavirus by monoclonal antibodies.2005

Author(s)

Journal Title

NAID

Data Source

[Journal Article] How preBCR signal is generated2004

Author(s)

Journal Title

Description

OHNISHI Kazuo 大西和夫

大西和夫オオニシカズオ