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NARIUCHI Hideo
成内 秀雄
Connect your ORCID iD
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Alternative Names
成内 秀雄 ナリウチ ヒデオ
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Researcher Number
10012741
Affiliation (based on the past Project Information)
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2000: University of Tokyo Institute of Medical Science Department of Allergology Emeritus Professor, 医科学研究所, 名誉教授
1988 – 1999: 東京大学, 医科学研究所, 教授
1993: 東京大学医科学研究所, アレルギー部門, 教授
1986: 東大, 医科学研究所, 教授
1985: 東京大学, 医科研, 教授
Review Section/Research Field
Principal Investigator
内科学一般
/
Immunology
Except Principal Investigator
Digestive surgery
/
Biological Sciences
/
Immunology
/
老化(加齢)
/
細菌学
/
内科学一般
/
寄生虫学(含医用動物学)
/
General surgery
/
Bacteriology (including Mycology)
Keywords
Principal Investigator
T細胞亜集団 / IL-12 / TNF / 細胞傷害性T細胞 / トランスジェニックマウス / 血管新生抑制 / 腫瘍壊死 / IL-12p35 / B7 / CD28
…
More
/ CD152 / インターロイキン2受容体発現因子 / 分離精製 / ヘルパーT細胞 / 第二シグナル / IL-2受容体 / シグナル伝達経路 / ナイーブとメモリー / 遺伝子構造 / IL-12産生 / CD40-CD40L / Th1 / Th2 / IL-10 / B7分子 / IL-12遺伝子 / 移植腫瘍 / 免疫記憶 / 遺伝子導入 / Fas-FasL反応 / IL-12遺伝子導入腫瘍 / IRES / IL-12p40トランスジェニックマウス / 肝転移モデル / 血管内皮細胞 / 増殖抑制 / 培養 / 血管内皮傷害作用 / インターロイキン2受容体 / 未知液性因子 / 活性化T細胞 / CD4T細胞CD8T細胞 / 炎症 / サイトカイン / インターフェロン / Tヘルパー細胞亜集団 / 腫瘍壊死因子 / 内毒素 / 炎症反応 / インターロイセン1 / Inflammation / Cytokine / Tumor necrosis factor / Interferon / T helper cell subset / IL-12p40 / MHCクラスII / IL-12非依存性Th1分化 / IL-12受容体 / IL-12Rβ2 / B7刺激 / 副刺激 / T細胞抗原受容体 / T細胞上B7-2発現 / IL-2p40 / MHC class II / IL-12 independent TH1 differentiation
…
More
Except Principal Investigator
IFN-γ / IL-12 / マラリア / NO / MHC Class II / CD28 / CTLA-4 / ワクチン / アポトーシス / 赤内型マラリア感染 / NK細胞 / 貪食能 / 赤内型マラリア / 硼素化合物 / 熱中性子照射 / 中性子捕捉療法 / Thermal neutron / vaccine / Immunoliposome / HIV / gp120 / 自己免疫病 / 防御免疫 / MAIDS / LMFS / HCFU / ND2001 / p-53 / point mutation / Fas / BRM / p35 / Fc Receptor / T細胞 / 細胞内情報伝達 / 加齢 / 感染免疫防御 / サイトカイン / シグナル伝達 / リンパ球 / STAT / 増殖抑制 / 抗原受容体 / 免疫異常 / 免疫病 / レセプター / 情報伝達 / 細胞増殖 / 防御免疫機構 / CD4^+T細胞 / FcR / FcRγ鎖KOマウス / DTH反応 / 可溶性CD4 / IFN-Y / 細胞性免疫反応 / IL-12 Rceptor / Two-Hybrid Screening / Retroviral Expression Cloning / B7-1 / 2 / 中性子捕促療法 / リポソ-ム / 抗CEA単クロ-ン抗体 / 抗CEAモノクロナ-ル抗体 / Boron neutron capture therapy / ^<10>B compound / Liposome / Anti CEA monoclonal antibody / 赤痢菌 / 病原性 / ビルレンス / 組換えDNA実験 / 細胞侵入性 / 分子遺伝学 / 組換えDNA / 赤痢 / サル実験 / 分子遺伝学的解析 / 免疫病理学 / Shigella flexneri / pathogenicity / virulence / recombinant DNA experiments / cell invasion / molecular genetics / 熱中性子 / 抗CEA単クローン抗体 / イムノリポソーム / Boron neutron capture therapy (BNCT) / ^<10>B-compound / Anti-CEA monoclonal antibody / 自己免疫 / 1pr^<cg>遺伝子 / イディオタイプネットワーク / 自己免疫マウス / 抗gp120抗体 / autoimmunity / lpr^<cg> gene / idiotype network / ウエスタンブロット / ポリペプチド / 電気泳動 / モノクローナル抗体 / アフィニティクロマトグラフィ / ウェスタンブロ-ト / モノクロナール抗体 / アフインティクロマトグラフィ / 熱帯熱マラリア原虫 / 抗原蛋白 / malaria / Western blot / polypeptide / electrophoresis / monoclonal antibody / affinity chromatography / protective immunity / HIV感染者 / 外科手術 / 手術適応基準 / 創傷治癒 / 線維芽細胞 / 創傷治癒能 / MAIDSマウス / 引張力 / 抗張力 / HIV-infected patient / Surgical operation / Criteria for surgical indications / wound healing / fibroblast / 自然肝転移 / 転移抑制 / 化学療法 / 浸潤 / spontaneous liver metastasis / Inhibition of metastasis / chemotherapy / アンタゴニスト / ペプチド / 細胞死 / 受容体 / 化学修飾 / 生体応答調節薬 / 遮断剤 / ペプチド合成 / Antagonist / Peptide / Cell death / Apoptosis / receptor / Chemical modification / マラリア感染 / 病態形成 / 組み換えウイルス / 組み替えウイルス / 感染防御 / Malaria Infection / Host Resistance / Vaccine / IFN-gamma. / Pathogenesis / Recombinant Virus / IL-12p40 / IL-12Receptor / Fc Beceptor / MHCクラスII / 貧食能 / IL-12p35 / IL-12 p40 / IL-12 Receptor / Autoimmune Diseases / Blood-Stage Malaria Infection
Less
Research Projects
(
29
results)
Co-Researchers
(
41
People)
Project Start Year (Newest)
Project Start Year (Oldest)
Th1反応における情報伝達制御機構の解明-IL-12Rを介したIFN-γ産生へのシグナル伝達-
Principal Investigator
善本 隆之
Project Period (FY)
2000
Research Category
Grant-in-Aid for Scientific Research on Priority Areas (A)
Review Section
Biological Sciences
Research Institution
Tokyo Medical University
マラリア感染に対する防御免疫機構-赤内型P.berghel強毒株NK65とその弱毒株XATを用いた解析-
Principal Investigator
善本 隆之
Project Period (FY)
1999
Research Category
Grant-in-Aid for Scientific Research on Priority Areas (A)
Research Institution
The University of Tokyo
免疫機能低下の機構解明
Principal Investigator
善本 隆之
Project Period (FY)
1999
Research Category
Grant-in-Aid for Scientific Research on Priority Areas (A)
Review Section
Biological Sciences
Research Institution
The University of Tokyo
Studies on the regulation of IL-12 expression and function and its application to therapy
Principal Investigator
YOSHIMOTO Takatyuki
Project Period (FY)
1999 – 2000
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Immunology
Research Institution
Tokyo Medical University
The University of Tokyo
マラリア感染における防御免疫機構の研究-赤内型P.berghei強毒株NK65とその弱毒株XATを用いた検討-
Principal Investigator
善本 隆之
Project Period (FY)
1998
Research Category
Grant-in-Aid for Scientific Research on Priority Areas (A)
Research Institution
The University of Tokyo
IL-12遺伝子導入腫瘍を用いた抗腫瘍効果機序の基礎的研究
Principal Investigator
Principal Investigator
成内 秀雄
Project Period (FY)
1997
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
Study on the role of IL-12 in protective immunity against infection
Principal Investigator
YOSHIMOTO Takayuki
Project Period (FY)
1997 – 1998
Research Category
Grant-in-Aid for international Scientific Research
Research Field
Immunology
Research Institution
The University of Tokyo
Elucidation of T cell subset Th1 differentiation by IL-12
Principal Investigator
Principal Investigator
NARIUCHI Hideo
Project Period (FY)
1997 – 1999
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Immunology
Research Institution
The University of Tokyo
IL-12遺伝子をもちいた癌免疫療法開発の基礎的研究
Principal Investigator
Principal Investigator
成内 秀雄
Project Period (FY)
1996
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
IL-12による弱毒化マラリア原虫のワクチン効果増強に関する基礎的研究
Principal Investigator
善本 隆之
Project Period (FY)
1996
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
情報伝達とリンパ球の機能分化
Principal Investigator
宮園 浩平
Project Period (FY)
1996 – 1999
Research Category
Grant-in-Aid for Scientific Research on Priority Areas (A)
Research Institution
Japanese Foundation For Cancer Research
Molecular design of BRMs using synthetic peptide libraries
Principal Investigator
OHMI Shinobu
Project Period (FY)
1996 – 1997
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
Bacteriology (including Mycology)
Research Institution
The University of Tokyo
T細胞亜集団による免疫制御の分子機構
Principal Investigator
Principal Investigator
成内 秀雄
Project Period (FY)
1995
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
IL-12遺伝子をもちいた癌免疫療法開発の基礎的研究
Principal Investigator
Principal Investigator
成内 秀雄
Project Period (FY)
1995
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
INVESTIGATION OF SPONTANEOUS LIVER METASTASIS MODEL OF BALB/c REIROPERITONEAL SARCOMA (LMFS) AND CLINICAL APPLICATION
Principal Investigator
FUJII Yuzo
Project Period (FY)
1995 – 1996
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Digestive surgery
Research Institution
The University of Tokyo
T細胞亜集団による免疫制御の分子機構
Principal Investigator
Principal Investigator
成内 秀雄
Project Period (FY)
1994
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
Studies on purification isolation and immunological characterization of 47kD and 23kD polypeptide from blood stage P.falciparum parasite
Principal Investigator
SUZUKI Mamoru
Project Period (FY)
1994 – 1995
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
寄生虫学(含医用動物学)
Research Institution
Gunma University School of Medicine
Study for wound healing in HIV-infected patients
Principal Investigator
ERIGUCHI Masazumi
Project Period (FY)
1994 – 1995
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
General surgery
Research Institution
The University of Tokyo
T細胞亜集団による免疫制御の分子機構
Principal Investigator
Principal Investigator
成内 秀雄
Project Period (FY)
1993
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
T細胞におけるシグナル伝達の分子機能:その加齢変化
Principal Investigator
宇津山 正典
Project Period (FY)
1993
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
老化(加齢)
Research Institution
Tokyo Metropolitan Institute of Gerontology
Role of anti-HIV-gp120 antibody in the lpr^<cg> and other autoimmune mice.
Principal Investigator
KIMURA Mikio
Project Period (FY)
1993 – 1994
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
内科学一般
Research Institution
The University of Tokyo
Analysis of cytokine cascade in inflammatory reaction and application for the regulation
Principal Investigator
Principal Investigator
NARIUCHI Hideo
Project Period (FY)
1992 – 1993
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
内科学一般
Research Institution
The University of Tokyo
Application of monoclonal antibody against solid tumor to boron neutron capture therapy model
Principal Investigator
FUJII Yuzo
Project Period (FY)
1992 – 1993
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Digestive surgery
Research Institution
The University of Tokyo
Developement of live attenuated anti-Shigella vaccine based on molecular pathogenesis studies
Principal Investigator
YOSHIKAWA Masanosuke
Project Period (FY)
1991 – 1993
Research Category
Grant-in-Aid for Developmental Scientific Research (B)
Research Field
細菌学
Research Institution
The University of Tokyo
ILー2受体発現増強因子を用いたキラーT細胞高能率誘導法
Principal Investigator
Principal Investigator
成内 秀雄
Project Period (FY)
1989
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokyo
Application of Anti CEA-Immunoliposome to boron neutron capture therapy
Principal Investigator
FUJII Yuzo
Project Period (FY)
1989 – 1991
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Digestive surgery
Research Institution
The Institute of medical Science, University of Tokyo
IL-2受容体発現増強因子を用いた抗腫瘍活性細胞誘導の試み
Principal Investigator
Principal Investigator
成内 秀雄
Project Period (FY)
1988
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokyo
TNF(腫瘍壊死因子)の抗腫瘍活性機序の解明
Principal Investigator
Principal Investigator
成内 秀雄
Project Period (FY)
1986
Research Category
Grant-in-Aid for Special Project Research
Research Institution
The University of Tokyo
TNF(腫瘍壊死因子)の抗腫瘍活性機序の解明
Principal Investigator
Principal Investigator
成内 秀雄
Project Period (FY)
1985
Research Category
Grant-in-Aid for Special Project Research
Research Institution
The University of Tokyo
# of Projects (Dsc)
# of Projects (Asc)
1.
YOSHIMOTO Takayuki
(80202406)
# of Collaborated Projects:
15 results
# of Collaborated Products:
0 results
2.
KATO Takuma
(60224515)
# of Collaborated Projects:
7 results
# of Collaborated Products:
0 results
3.
FUJII Yuzo
(40143515)
# of Collaborated Projects:
4 results
# of Collaborated Products:
0 results
4.
脇 誠治
(10056286)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
5.
TOMITA Toshio
(00126129)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
6.
KOBAYASHI Hisao
(10062605)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
7.
YANAGIE Hironobu
(30212278)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
8.
MORI Shigero
(30010424)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
9.
MATSUZAWA Akio
(50012745)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
10.
平良 珠美子
(80154722)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
11.
SEKIGUCHI Morimasa
(60012712)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
12.
YOSHIKAWA Masanosuke
(80012714)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
13.
SASAKAWA Chihiro
(70114494)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
14.
DANBARA Hirobumi
(40114558)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
15.
SHIMADA Hiroyuki
(60113487)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
16.
TAKASAKA Masao
(80072924)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
17.
KIMURA Mikio
(90114462)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
18.
SUZUKI Mamoru
(60056033)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
19.
NAKAMURA Masatoshi
(10251092)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
20.
KANO Shigeyuki
(60233912)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
21.
ERIGUCHI Masazumi
(10114406)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
22.
OHMI Shinobu
(20160046)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
23.
NAKATA Ko
(80207802)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
24.
TAMURA Toshiki
(40291306)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
25.
宇津山 正典
(70167287)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
26.
広川 勝〓
(00014093)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
27.
白沢 卓二
(80226323)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
28.
石島 早苗
(80147214)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
29.
宮園 浩平
(90209908)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
30.
渡邊 武
(40028684)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
31.
田賀 哲也
(40192629)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
32.
吉村 昭彦
(90182815)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
33.
徳久 剛史
(20134364)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
34.
宮島 篤
(50135232)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
35.
菅村 和夫
(20117360)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
36.
江川 滉二
(00012724)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
37.
原中 勝征
(90012757)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
38.
高橋 司
(90143510)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
39.
木村 哲
(60010352)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
40.
SAEGUSA Yoshiyuki
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
41.
TSUJI Moriya
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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