Yoshimura Akihiko 吉村昭彦

… Alternative Names

YOSHIMURA Akihiko 吉村昭彦

吉村昭彦

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Researcher Number	90182815
Other IDs
Affiliation (Current)	2023: 慶應義塾大学, 医学部(信濃町), 教授
Affiliation (based on the past Project Information) *help	2016 – 2023: 慶應義塾大学, 医学部(信濃町), 教授 2008 – 2017: Keio University, 医学部, 教授 2008: 九大, 生体防御医学研究所, 教授 2001 – 2007: Kurume University, Institute of Life Science, Professor, 生体防御医学研究所, 教授 2001: 久留米大, 教授 … More 1995 – 2000: 久留米大学, 分子生命科学研究所, 教授 1992 – 1995: 鹿児島大学, 医学部, 助教授 1988: 鹿児島大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Immunology / Cell biology / Immunology / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Biological Sciences / Broad Section H / Functional biochemistry / General medical chemistry / Pathological medical chemistry Except Principal Investigator Biological Sciences … More / Basic Section 49030:Experimental pathology-related / Gastroenterology / Pathobiological dentistry/Dental radiology / Hematology / Natural medicines / Life / Health / Medical informatics / Pediatrics / General medical chemistry / Pathological medical chemistry / 膠原病・アレルギー・感染症内科学 / Bioinformatics/Life informatics / Immunology / 血管生物学 Less
Keywords	Principal Investigator STAT / サイトカイン / JAK / チロシンキナーゼ / シグナル伝達 / SH2ドメイン / 転写因子 / 情報伝達 / エリスロポエチン / 炎症 … More / りん酸化 / CIS / インターフェロン / SOCS / ノックアウトマウス / tyrosine kinase / TGFβ / ヘルパーT細胞 / プロモーター / cytokine / T細胞 / 免疫学 / 制御性T細胞 / 自己免疫疾患 / アレルギー / チロシンりん酸化 / 細胞分化 / 細胞増殖 / 獲得免疫 / 腫瘍免疫 / knockout mice / SH2 domain / 脳梗塞 / TGF-β / 抑制性T細胞 / Ras / c-Cbl / c-kit / 誘導遺伝子 / 分化 / 免疫記憶 / アレルギー・喘息 / 免疫 / 抗腫瘍免疫 / Notchシグナル / 代謝 / メモリーT細胞 / interferon / tyrosine phosphorylation / 胎児造血 / CISファミリー / erythropoietin / 組織損傷 / マクロファージ / シミュレーション / 免疫制御 / 肝がん / 肝炎 / MAPキナーゼ / エリスポエチン / EGF受容体 / インターロイキン / 増殖抑制 / 造血因子 / 分子生物学 / キメラ分子 / 活性化 / 情報伝達機構 / 受容体 / エリスロポエチン受容体 / 疲弊 / パーキンソン病 / アルツハイマー病 / グリア細胞 / T細胞受容体 / アルツハイマー / ミクログリア / 脳内炎症 / ミトコンドリア / DNAメチル化 / PD1 / 酸化的りん酸化 / 核内受容体 / T細胞疲弊 / 記憶T細 / 脳・神経 / 神経症状 / アストロサイト / 創傷治癒 / 慢性炎症 / 細胞・組織 / 生理活性 / 生体分子 / 脳神経 / 組織修復 / 神経炎症 / 癌 / リプログラム / 細胞老化 / 記憶T細胞 / 幹細胞メモリーT細胞 / 細胞移入療法 / 分化制御 / Notch / 疲弊化 / hepayoma / hepatitis / tyrosine phsphorylation / inflammation / 細胞膜 / Raf / FGF受容体 / HPV / ユビキチン化 / MITF / kinase inhibitor / APS / fetal liver hematopoiesis / Ubiquitin / Knockout mouse / Transgenic mouse / Tyrosine Kinase / Cytokine / ユビキチン / トランスジェニックマウス / differentiation / transcription factor / signal transduction / サブトラクション / 転写調節 / Tyrosine kinase / Activation / Dimerization / Epidermal growth factor / Erythropoietin / 受容体活性化 / 遺伝子発現制御 / エピジェネティクス / モデル化 / インフラマゾーム / 自然免疫 / 細菌 / 生体恒常性 / 組織傷害 / アレルギー・ぜんそく / レチノイン酸受容体 / スカベンジャー受容体 / 修復機構 / 修復 / 組織障害 / サイトカインシグナル伝達 / RORgammat / 胸腺 / Foxp3 / TGFーβ / 免疫応答 / アレルギー自己免疫疾患 / 負の制御 / Ras c-fos / 樹状細胞 / 細胞 / ヘルパーT / Sred / 神経繊維腫I型 / Spred / 発がん / 家族性変異 / ERK / コクサッキーウイルス / アデノウイルス / 関節リウマチ / 炎症性疾患 / 大腸炎 / 関節炎リウマチ / キナーゼ抑制因子 / 脂質ラフト / 好酸球 / 消化管神経 / チロシンキナ一ゼ / PH / SH2 / チロキシンギナーゼ / STAT5 / JAK2 / SATA / がん抑制遺伝子 / クローニング / オンコスタチンM / GAS / 赤血球増多症 / 二量体化 … More Except Principal Investigator サイトカイン / STAT / JAK / CIS / チロシンキナーゼ / キナーゼ抑制因子 / チロシンりん酸化 / 転写因子 / 細胞増殖 / シグナル伝達 / PD-ECGF / 免疫学 / 制御性T細胞 / tyrosine phosphorylation / cytokine / tyrosine kinase / JAB / ノックアウトマウス / MRP / 多剤耐性 / 粘膜免疫 / Th17 / シミュレーション / ヘルパーT細胞 / 大腸炎 / 自己免疫疾患 / リンパ球 / 血管新生 / チミジンホスホリラーゼ / 低分子化合物 / SOCSファミリー分子 / サイトカインシグナル / IL-21 / SOCS3 / IL6 / エフェクター / ミトコンドリア / CAR-T細胞 / 代謝 / エフェクター細胞 / T細胞 / 腫瘍免疫 / 内科 / 急性腸炎 / 核内受容体 / Hirschprung病 / 腸管免疫 / Nr4a3 / 腸管神経叢 / 核内オーファン受容体 / ヒルシュスプルング病 / セロトニン / カルシトニン関連ペプチド / 細菌感染 / PI3K / IL-10 / 血管内皮細胞 / エピジェネティクス / 造血幹細胞 / Treg / ジンコウ / インターフェロンガンマ / 癌 / 沈香 / 天然物 / 生薬 / 免疫賦活 / マクロファージ / 滑膜細胞 / コンピュータシミュレーション / NFkB / IL-6 / 炎症アンプ / F759マウス / リウマチ / ubiquitin ligase / leukemia / SOCS1 / oncogene / TEL / kinase inhibitor / knockout mice / 分化 / SH2ドメイン / Progesterone / Topoisomerase / Glutathione-S-transferase / Adriamycin / Multidrug resistance / P-glycoprotein / アドリアマイシン / プロゲステロン / トポイソメラーゼ / グルタチオンSトランスフェラーゼ / アドリアマイシン耐性 / P-糖蛋白質 / Prognosis / Metastasis / Thrombomodulin / Colorectal carcinoma / Deoxyribose / Angiogenic factor / Thymidine Phosphorylase / 予後 / 転移 / トロンボモジュリン / 大腸癌 / デオキシリボース / 血管新生因子 / ジヒドロピリジン誘導体 / フォトアフィニティーラベル法 / 耐性克服 / 温度感受性変異株 / 細胞内取り込み過程 / エンドサイトーシス / トランスフェリン / 上皮生長因子 / 腸管粘膜 / 食物アレルギー / 微生物 / 食品 / アレルギー / iTreg / 免疫ネットワーク / 関節炎リウマチ / SOCS / IRF / 自然免疫 / 免疫抑制 / アクチン / p21 / イメージング / 1分子 / FRET / GFP / 細胞内局在 / EGF受容体 / 一分子観察 / 蛍光顕微鏡 / Raf / Ras / 細胞分化 / キナーゼ / 受容体 / 造血因子 / 細胞がん化 / Cdk2 / サイクリンE / ユビキチンリガーゼ / E6AP / 情報伝達 / レセプター / 免疫病 / 免疫異常 / アポトーシス / 抗原受容体 / 増殖抑制 / 細胞膜蛋白質 / シスプラチンの排出ポンプ / シスプラチンの蓄積 / ヒト癌KB細胞 / シスプラチン耐性 Less

Elucidation of the molecular mechanism of memory T cell exhaustion and development of its reprogramming methodPrincipal Investigator
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Keio University
Brain inflammation and repair mechanism by adaptive immunityPrincipal Investigator
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section H
- Research Institution
  Keio University
Development of T cell reprogramming method by metabolic and epigenomic modificationPrincipal Investigator
- Principal Investigator
  
  Yoshimura Akihiko
- Project Period (FY)
  2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Keio University
Enhancement of anti-tumor response by augmentation by cytokine signaling.
- Principal Investigator
  
  Mise-Omata Setsuko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Keio University
Immune systems involved in the resolution of inflammation and tissue repairPrincipal Investigator
- Principal Investigator
  
  YOSHIMURA Akihiko
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Immunology
- Research Institution
  Keio University
Generation and Application of Stem Cell Memory T CellsPrincipal Investigator
- Principal Investigator
  
  Yoshimura Akihiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Keio University
The role of Nr4a3 on intestinal homeostasis
- Principal Investigator
  
  Keita Saeki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Direct reprogramming of human fibroblasts into hematopoietic cells mainly using ETV2
- Principal Investigator
  
  Morita Rimpei
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Keio University
Differentiation and function of Foxp3-negative IL-10-producing regulatory T cells on mucosal bacterial infection
- Principal Investigator
  
  Nagai Shigenori
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Tokyo Medical and Dental University
Identification of Cellular Signaling Mechanism that regulates inflammation and tissue repairingPrincipal Investigator
- Principal Investigator
  
  YOSHIMURA Akihiko
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Immunology
- Research Institution
  Keio University
Systemic Biology of T cell differentiationPrincipal Investigator
- Principal Investigator
  
  YOSHIMURA Akihiko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Keio University
Development of simulation method of behaviors in the body based on signal transduction pathway
- Principal Investigator
  
  YAMADA SATOSHI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Life / Health / Medical informatics
- Research Institution
  Okayama University of Science
The search and functional analysis of the natural compound promoting the differentiation of regulatory T cells.
- Principal Investigator
  
  KOTANI Hitoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Natural medicines
- Research Institution
  Musashino University
Commensal bacteria suppresses food allergy by inhibiting ILC2 cytokine production through the induction of IL-17 producing cells
- Principal Investigator
  
  RYUSUKE Nakagawa
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Keio University
  University of Yamanashi
Systembiology of T-cell differentiationPrincipal Investigator
- Principal Investigator
  
  YOSHIMURA Akihiko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Keio University
Regulatory Mechanisms of the Balance between Inflammation andAnti-inflammation by CutokinesPrincipal Investigator
- Principal Investigator
  
  YOSHIMURA Akihiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Keio University
Development of simulation method of cell group population based on signal transduction pathway's behaviors
- Principal Investigator
  
  YAMADA Satoshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioinformatics/Life informatics
- Research Institution
  Okayama University of Science
ヘルパーT細胞分化のシミュレーションPrincipal Investigator
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Keio University
Molecular Mechanism of Regulation of the Cytokine Signal and ImmunityPrincipal Investigator
- Principal Investigator
  
  YOSHIMURA Akihiko
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Immunology
- Research Institution
  Keio University
  Kyushu University
Abnormal differentiation of tumor cells and tyrosine kinase regulationPrincipal Investigator
- Principal Investigator
  
  YOSHIMURA Akihiko
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
  Kyushu University
免疫系におけるCISファミリー遺伝子群の機能解析Principal Investigator
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Kurume University
JAK/STATシグナル伝達系アンタゴニストの検索法の開発と応用Principal Investigator
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Kurume University
炎症性疾患におけるCIS/JAB遺伝子群の意義の解明
- Principal Investigator
  
  脇岡徹
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Kurume University
サイトカインのシグナル制御機構とその破綻Principal Investigator
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  Kyushu University
サイトカイン、接着分子の情報伝達制御
- Principal Investigator
  
  平野俊夫
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Mechanism of Regulation of Tyrosine Kinase SignalingPrincipal Investigator
- Principal Investigator
  
  YOSHIMURA Akihiko
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
  Kurume University
Suppressopm of growth of leukemia cells by a tyrosine kinase inhibitor JAB
- Principal Investigator
  
  KATO Reiko, 神薗慎太郎
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
サイトカインシグナル伝達経路の可視化
- Principal Investigator
  
  MINOGUCHI Shigeru, 安川秀雄
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (B)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
  Kurume University
赤血球産生を制御するシグナル伝達分子の探索と機能解析Principal Investigator
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Kurume University
Physiological function and Molecular mechanism of regulation by the CIS/JAB family membersPrincipal Investigator
- Principal Investigator
  
  YOSHIMURA Akihkio
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Functional biochemistry
- Research Institution
  Kurume University
CISファミリーによるJAKシグナルの制御機構と生理機能Principal Investigator
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kurume University
造血細胞のシグナル伝達
- Principal Investigator
  
  宮島篤
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
赤血球分化に関与するシグナル伝達分子の探索と機能解析Principal Investigator
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Kurume University
Screening of signal transducing molecules by using transient expressionPrincipal Investigator
- Principal Investigator
  
  YOSHIMURA Akihiko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Kurume University
Molecular mechanism of negative regulation of JAK/STAT pathway by the CIS/JAB family members
- Principal Investigator
  
  YASUKAWA Hideo
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kurume University
造血細胞の増殖と分化を制御するシグナル伝達分子群の解析Principal Investigator
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
c-kitおよびJAKキナーゼの新規基質の単離と機能解析Principal Investigator
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
サイクリンE-p21特異的なユビキチンリガーゼの解析
- Principal Investigator
  
  大坪素秋
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
赤血球分化に関する情報伝達分子の探索と機能解析Principal Investigator
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Kurume University
Physiological Function and Signal Transduction Mechanism of the STAT5-target genesPrincipal Investigator
- Principal Investigator
  
  YOSHIMURA Akihiko
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Cell biology
- Research Institution
  Kurume University
Growth and differentiation signals of the erythropoietin receptorPrincipal Investigator
- Principal Investigator
  
  YOSHIMURA Akihiko
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kurume university
造血細胞の増殖と分化を制御するシグナル伝達分子群の解析Principal Investigator
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
SH2ドメインを有する新規情報伝達分子CISの機能解析Principal Investigator
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
情報伝達とリンパ球の機能分化
- Principal Investigator
  
  宮園浩平
- Project Period (FY)
  1996 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Japanese Foundation For Cancer Research
免疫系におけるJAKキナーゼを介した情報伝達経路と標的遺伝子Principal Investigator
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
サイトカイン受容体の情報伝達機構とその標的遺伝子の解析Principal Investigator
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Kurume University
造血幹細胞の増殖と分化を制御するシグナル伝達分子群の解析Principal Investigator
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
SH2ドメインを有する新規情報伝達分子CISの機能解析Principal Investigator
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
Growth and Differentiation through the Cytokine ReceptorsPrincipal Investigator
- Principal Investigator
  
  YOSHIMURA Akihiko
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Institute of Life Science, Kurume University
造血幹細胞の増殖を制御するシグナル伝達分子群の解析Principal Investigator
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kagoshima University
エリスロポエチン受容体の情報伝達機構と細胞増殖およびがん化との関連Principal Investigator
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kagoshima University
The mechanism of regulation of P-glycoprotein (Analysis of multidrug-resistant mutants that do not express P-glycoprotein)
- Principal Investigator
  
  HARAGUCHI Misako
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kagoshima University
サイトカイン受容体の構造と情報伝達機構の分子機序に関する共同研究Principal Investigator
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kagoshima University
エリスロポエチン受容体の情報伝達機構と細胞増殖およびがん化との関連Principal Investigator
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kagoshima University
チミジンホスホリラーゼ活性と血管新生の関連性について
- Principal Investigator
  
  秋山伸一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  血管生物学
- Research Institution
  Kagoshima University
The mechanism of angiogenesis by PD-ECGF
- Principal Investigator
  
  AKIYAMA Shin-ichi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kagoshima University
Structure and Signal Transduction of the Erythropoietin ReceptorPrincipal Investigator
- Principal Investigator
  
  YOSHIMURA Akihiko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Cancer Research Institute, Faculty of Medicine, Kagoshima University
シスプラチン耐性機構の解析と耐性克服方法の開発
- Principal Investigator
  
  AKIYAMA Shin-ichi
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kagoshima University
多剤耐性遺伝子の発現と耐性腫瘍出現の関連性、およびP-糖蛋白質の機能の解析
- Principal Investigator
  
  秋山伸一
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kagoshima University
上皮生長因子とトランスフェリンの細胞内取り込み過程欠損変異株の分離と解析
- Principal Investigator
  
  秋山伸一
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kagoshima University

[Book] ダイレクトリプログラミング　（第3章　線維芽細胞→血管内皮細胞）2015
- Author(s)
  森田林平、笠原秀範、吉村昭彦
- Total Pages
  11
- Publisher
  秀潤社
- Data Source
  KAKENHI-PROJECT-26670470
[Book] 細胞工学別冊　ダイレクトリプログラミング2015
- Author(s)
  森田林平、笠原秀範、吉村昭彦
- Total Pages
  119
- Publisher
  秀潤社
- Data Source
  KAKENHI-PROJECT-26670470
[Book] 日本臨牀増刊号　再生医療2015
- Author(s)
  森田林平、笠原秀範、吉村昭彦
- Total Pages
  584
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-26670470
[Journal Article] Microtubule-dependent mechanism of anti-inflammatory effect of SOCS1 in endothelial dysfunction and lung injury.2021
- Author(s)
  Karki P, Cha B, Zhang CO, Li Y, Ke Y, Promnares K, Kaibuchi K, Yoshimura A, Birukov KG, Birukova AA
- Journal Title
  
  FASEB J.
  
  Volume: 35 Issue: 4
- DOI
  10.1096/fj.202001477rr
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H05044
[Journal Article] SOCS3 Expression by Thymic Stromal Cells Is Required for Normal T Cell Development.2021
- Author(s)
  Gao Y, Liu R, He C, Basile J, Vesterlund M, Wahren-Herlenius M, Espinoza A, Hokka-Zakrisson C, Zadjali F, Yoshimura A, Karlsson M, Carow B, Rottenberg ME.
- Journal Title
  
  Front Immunol.
  
  Volume: 12
- DOI
  10.3389/fimmu.2021.642173
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H05044
[Journal Article] T 細胞のエピジェネティック改変による免疫疾患制御2021
- Author(s)
  吉村昭彦、中司寛子、三瀬節子
- Journal Title
  
  炎症と免疫
  
  Volume: 29 Pages: 533-539
- Data Source
  KAKENHI-PROJECT-19K07514
[Journal Article] SOCS: negative regulators of cytokine signaling for immune tolerance2021
- Author(s)
  Akihiko Yoshimura, Minako Ito, Setsuko Mise-Omata, Makoto Ando
- Journal Title
  
  International Immunology
  
  Volume: 33 Issue: 12 Pages: 711-716
- DOI
  10.1093/intimm/dxab055
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07514, KAKENHI-PROJECT-19J21508
[Journal Article] Single-Cell Analysis Revealed the Role of CD8+ Effector T Cells in Preventing Cardioprotective Macrophage Differentiation in the Early Phase of Heart Failure2021
- Author(s)
  Komai Kyoko、Ito Minako、Nomura Seitaro、Shichino Shigeyuki、Katoh Manami、Yamada Shintaro、Ko Toshiyuki、Iizuka-Koga Mana、Nakatsukasa Hiroko、Yoshimura Akihiko
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 763647-763647
- DOI
  10.3389/fimmu.2021.763647
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08891, KAKENHI-PROJECT-18K15129, KAKENHI-PROJECT-19K17587, KAKENHI-PUBLICLY-21H00432, KAKENHI-PROJECT-21H05044, KAKENHI-PROJECT-21H04821, KAKENHI-PROJECT-21H02719, KAKENHI-PROJECT-19J40137, KAKENHI-PROJECT-20K07541
[Journal Article] Rejuvenating Effector/Exhausted CAR T Cells to Stem Cell Memory-Like CAR T Cells By Resting Them in the Presence of CXCL12 and the NOTCH Ligand.2021
- Author(s)
  Makoto Ando; Taisuke Kondo; Wataru Tomisato; Minako Ito; Shigeyuki Shichino; Tanakorn Srirat; Setsuko Mise-Omata; Kensuke Nakagawara ; Akihiko Yoshimura
- Journal Title
  
  Cancer Research Communications
  
  Volume: 1 Issue: 1 Pages: 41-55
- DOI
  10.1158/2767-9764.crc-21-0034
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07514, KAKENHI-PROJECT-19J21508
[Journal Article] Regulation of peripheral Th/Treg differentiation and suppression of airway inflammation by Nr4a transcription factors.2021
- Author(s)
  Takashi Sekiya, Shizuko Kagawa, Katsunori Masaki, Koichi Fukunaga, Akihiko Yoshimura, Satoshi Takaki .
- Journal Title
  
  iScience.
  
  Volume: 24 Issue: 3 Pages: 102166-102166
- DOI
  10.1016/j.isci.2021.102166
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-17H06175, KAKENHI-PROJECT-18H02673, KAKENHI-PROJECT-20K20384, KAKENHI-PUBLICLY-19H04822
[Journal Article] Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell?mediated inflammation in the skin2021
- Author(s)
  Takahashi H.、Nomura H.、Iriki H.、Kubo A.、Isami K.、Mikami Y.、Mukai M.、Sasaki T.、Yamagami J.、Kudoh J.、Ito H.、Kamata A.、Kurebayashi Y.、Yoshida H.、Yoshimura A.、Sun H. W.、Suematsu M.、O’Shea J. J.、Kanno Y.、Amagai M.
- Journal Title
  
  Science Immunology
  
  Volume: 6 Issue: 64
- DOI
  10.1126/sciimmunol.abb6444
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07627, KAKENHI-PROJECT-21H05044, KAKENHI-PROJECT-19H01051, KAKENHI-PROJECT-20H03666
[Journal Article] TRIM28 Expression on Dendritic Cells Prevents Excessive T Cell Priming by Silencing Endogenous Retrovirus2021
- Author(s)
  Chikuma Shunsuke、Yamanaka Soichiro、Nakagawa So、Ueda Mahoko Takahashi、Hayabuchi Hodaka、Tokifuji Yukiko、Kanayama Masashi、Okamura Tadashi、Arase Hisashi、Yoshimura Akihiko
- Journal Title
  
  The Journal of Immunology
  
  Volume: 206 Issue: 7 Pages: 1528-1539
- DOI
  10.4049/jimmunol.2001003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06616, KAKENHI-PUBLICLY-19H04816, KAKENHI-PUBLICLY-19H05431, KAKENHI-PROJECT-17H06175, KAKENHI-PROJECT-20K20384, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K07488, KAKENHI-PUBLICLY-21H00439, KAKENHI-PROJECT-21H05044
[Journal Article] サイトカインストームとT細胞疲弊　コロナウィルス感染を中心に2021
- Author(s)
  三瀬節子、安藝大輔、池田真理、吉村昭彦
- Journal Title
  
  実験医学
  
  Volume: 39 Pages: 505-511
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07514
[Journal Article] Kidney GATA3+ regulatory T cells play roles in the convalescence stage after antibody-mediated renal injury.2020
- Author(s)
  Sakai R, Ito M, Komai K, Iizuka-Koga M, Matsuo K, Nakayama T, Yoshie O, Amano K, Nishimasu H, Nureki O, Kubo M, Yoshimura A.
- Journal Title
  
  Cell Mol Immunol.
  
  Volume: Sep Issue: 5 Pages: 11-11
- DOI
  10.1038/s41423-020-00547-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H04817, KAKENHI-PROJECT-17H06175, KAKENHI-PROJECT-19H03491, KAKENHI-PROJECT-19K16618, KAKENHI-PROJECT-19K08891, KAKENHI-PROJECT-19J40137
[Journal Article] 核内受容体NR4aによるT細胞疲弊と免疫寛容の制御2020
- Author(s)
  安藤　眞、三瀬節子、大谷木正貴、吉村昭彦
- Journal Title
  
  実験医学
  
  Volume: 38 Pages: 3178-3306
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07514
[Journal Article] The NOTCH-FOXM1 Axis Plays a Key Role in Mitochondrial Biogenesis in the Induction of Human Stem Cell Memory-like CAR-T Cells.2020
- Author(s)
  Kondo T, Ando M, Nagai N, Tomisato W, Srirat T, Liu B, Mise-Omata S, Ikeda M, Chikuma S, Nishimasu H, Nureki O, Ohmura M, Hayakawa N, Hishiki T, Uchibori R, Ozawa K, Yoshimura A
- Journal Title
  
  Cancer Res
  
  Volume: 80 Issue: 3 Pages: 471-483
- DOI
  10.1158/0008-5472.can-19-1196
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07488, KAKENHI-PROJECT-19K07514, KAKENHI-PROJECT-19K23850, KAKENHI-PUBLICLY-19H04816, KAKENHI-PROJECT-20K20384, KAKENHI-PROJECT-18K15290, KAKENHI-PROJECT-16H06276
[Journal Article] Tocilizumab monotherapy uncovered the role of the CCL22/17-CCR4+ Treg axis during remission of crescentic glomerulonephritis2020
- Author(s)
  Sakai R, Ito M, Yoshimoto K, Chikuma S, Kurasawa T, Kondo T, Suzuki K, Takeuchi T, Amano K, Yoshimura A
- Journal Title
  
  Clin Transl Immunology
  
  Volume: 9 Issue: 11
- DOI
  10.1002/cti2.1203
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07488, KAKENHI-PROJECT-19K08890, KAKENHI-PUBLICLY-19H04816, KAKENHI-PUBLICLY-19H04817, KAKENHI-PUBLICLY-19H05431, KAKENHI-PROJECT-17H06175, KAKENHI-PROJECT-20K20384, KAKENHI-PROJECT-19K16618
[Journal Article] CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD.2020
- Author(s)
  Imura Y, Ando M, Kondo T, Ito M, Yoshimura A.
- Journal Title
  
  JCI Insight.
  
  Volume: 23;5(14) Issue: 14
- DOI
  10.1172/jci.insight.136185
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H04817, KAKENHI-PROJECT-17H06175, KAKENHI-PROJECT-19J21508, KAKENHI-PROJECT-20K20384, KAKENHI-PROJECT-19K16618
[Journal Article] The liver-brain-gut neural arc maintains the Treg cell niche in the gut2020
- Author(s)
  Teratani T, Mikami Y, Nakamoto N, Suzuki T, Harada Y, Okabayashi K, Hagihara Y, Taniki N, Kohno K, Sibata S, Miyamoto K, Ishigame H, Chu Po-Sung, Sujino T, Suda W, Hattori M, Matsui M, Okada T, Okano H, Inoue M, Yada T, Kitagawa Y, Yoshimura A, Tanida M, Tsuda M, Iwasaki Y, Kanai T.
- Journal Title
  
  Nature
  
  Volume: 585 Issue: 7826 Pages: 591-596
- DOI
  10.1038/s41586-020-2425-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22611, KAKENHI-PROJECT-20K17062, KAKENHI-PROJECT-17H05082, KAKENHI-PROJECT-17H06110, KAKENHI-PROJECT-17H06175, KAKENHI-PROJECT-19H05658, KAKENHI-PROJECT-20H00536, KAKENHI-PROJECT-19H04045, KAKENHI-PROJECT-20H03665, KAKENHI-PROJECT-20H03666, KAKENHI-PROJECT-20H04133, KAKENHI-PROJECT-20K20384, KAKENHI-PROJECT-19K22624, KAKENHI-PROJECT-18K14840, KAKENHI-PROJECT-18KK0246
[Journal Article] 抗腫瘍免疫におけるT細胞の疲弊とその回避2020
- Author(s)
  三瀬節子、大谷木正貴、吉村昭彦
- Journal Title
  
  腫瘍内科
  
  Volume: 26 Pages: 694-701
- NAID
  40022446757
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07514
[Journal Article] TGF-β-induced epigenetic deregulation of SOCS3 facilitates STAT3 signaling to promote fibrosis.2020
- Author(s)
  Dees C, Potter S, Zhang Y, Bergmann C, Zhou X, Luber M, Wohlfahrt T, Karouzakis E, Ramming A, Gelse K, Yoshimura A, Jaenisch R, Distler O, Schett G, Distler JH.
- Journal Title
  
  J Clin Invest.
  
  Volume: 印刷中 Issue: 5 Pages: 2347-2363
- DOI
  10.1172/jci122462
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06175
[Journal Article] NR4A transcription factors limit CAR T cell function in solid tumours2019
- Author(s)
  Chen Joyce、L?pez-Moyado Isaac F.、Seo Hyungseok、Lio Chan-Wang J.、Hempleman Laura J.、Sekiya Takashi、Yoshimura Akihiko、Scott-Browne James P.、Rao Anjana
- Journal Title
  
  Nature
  
  Volume: 567 Issue: 7749 Pages: 530-534
- DOI
  10.1038/s41586-019-0985-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15292, KAKENHI-PROJECT-17H06175, KAKENHI-PUBLICLY-19H04822, KAKENHI-PROJECT-18H02673, KAKENHI-PROJECT-20K20384, KAKENHI-PROJECT-16KT0114
[Journal Article] Tissue regulatory T cells and neural repair.2019
- Author(s)
  Ito M, Komai K, Nakamura T, Srirat T, Yoshimura A.
- Journal Title
  
  Int Immunol.
  
  Volume: Mar 20. pii: dxz031. Issue: 6 Pages: 361-369
- DOI
  10.1093/intimm/dxz031
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16J30001, KAKENHI-PROJECT-17K15667, KAKENHI-PROJECT-17H06175
[Journal Article] Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization, and IL-17 expression.2019
- Author(s)
  Nakatsukasa H, Oda M, Yin J, Chikuma S, Ito M, Koga-Iizuka M, Someya K, Kitagawa Y, Ohkura N, Sakaguchi S, Koya I, Sanosaka T, Kohyama J, Tsukada YI, Yamanaka S, Takamura-Enya T, Lu Q, Yoshimura A
- Journal Title
  
  International immunology
  
  Volume: 31 Issue: 5 Pages: 335-347
- DOI
  10.1093/intimm/dxz008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08085, KAKENHI-PROJECT-18K15198, KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-15H04744, KAKENHI-PROJECT-16J30001, KAKENHI-PROJECT-16K00562, KAKENHI-PROJECT-16K08847, KAKENHI-PROJECT-17K15667, KAKENHI-PROJECT-17H06175, KAKENHI-PROJECT-19K07488, KAKENHI-PROJECT-19K12344, KAKENHI-PROJECT-16H06295
[Journal Article] Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery2019
- Author(s)
  Ito Minako、Komai Kyoko、Mise-Omata Setsuko、Iizuka-Koga Mana、Noguchi Yoshiko、Kondo Taisuke、Sakai Ryota、Matsuo Kazuhiko、Nakayama Takashi、Yoshie Osamu、Nakatsukasa Hiroko、Chikuma Shunsuke、Shichita Takashi、Yoshimura Akihiko
- Journal Title
  
  Nature
  
  Volume: 565 Issue: 7738 Pages: 246-250
- DOI
  10.1038/s41586-018-0824-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15129, KAKENHI-PROJECT-18K15198, KAKENHI-PUBLICLY-17H05514, KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-17H05096, KAKENHI-PROJECT-16J30001, KAKENHI-PROJECT-16K08847, KAKENHI-PROJECT-16K09867, KAKENHI-PROJECT-17K19571, KAKENHI-PROJECT-17K15667, KAKENHI-PROJECT-17H06175, KAKENHI-PROJECT-20K20384
[Journal Article] Inhibition of Nr4a receptors enhances anti-tumor immunity by breaking Treg-mediated immune tolerance.2018
- Author(s)
  Hibino S, Chikuma S, Kondo T, Ito M, Nakatsukasa H, Omata-Mise S, Yoshimura A
- Journal Title
  
  Cancer Res
  
  Volume: Epub Issue: 11 Pages: 3027-3040
- DOI
  10.1158/0008-5472.can-17-3102
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-17H07088, KAKENHI-PROJECT-15J03260, KAKENHI-PROJECT-15J07566, KAKENHI-PROJECT-18K15198, KAKENHI-PROJECT-16K09867, KAKENHI-PROJECT-16K15292, KAKENHI-PROJECT-20K20384
[Journal Article] Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection.2018
- Author(s)
  Fujiwara S., Hoshizaki M., Ichida Y., Lex D., Kuroda E., Ishii KJ., Magi S., Okada M., Takao H., Gando M., Imai H., Hara R., Herzog H., Yoshimura A., Okamura H., Penninger JM., Slutsky AS., Uhlig S., Kuba K., and Imai Y.
- Journal Title
  
  Nature Microbiology
  
  Volume: 4(2) Issue: 2 Pages: 258-268
- DOI
  10.1038/s41564-018-0289-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-15H05970, KAKENHI-PLANNED-15H05978, KAKENHI-PROJECT-17H06179, KAKENHI-PROJECT-16H05256, KAKENHI-PROJECT-17H04028, KAKENHI-PROJECT-17K19693, KAKENHI-PROJECT-17H06175
[Journal Article] Generation and application of human induced-stem cell memory T cells for adoptive immunotherapy.2018
- Author(s)
  Taisuke Kondo Yuki Imura Shunsuke Chikuma Sana Hibino Setsuko Omata‐Mise Makoto Ando Takashi Akanuma Mana Iizuka Ryota Sakai Rimpei Morita Akihiko Yoshimura
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 7 Pages: 2130-2140
- DOI
  10.1111/cas.13648
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15290, KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-16K09867, KAKENHI-PROJECT-16K15292, KAKENHI-PROJECT-17K19398, KAKENHI-PROJECT-20K20384, KAKENHI-PROJECT-16H05178
[Journal Article] Nr4a Receptors Regulate Development and Death of Labile Treg Precursors to Prevent Generation of Pathogenic Self-Reactive Cells2018
- Author(s)
  Takashi Sekiya、Hibino Sana、Saeki Keita、Kanamori Mitsuhiro、Takaki Satoshi、Yoshimura Akihiko
- Journal Title
  
  Cell Reports
  
  Volume: 24 Issue: 6 Pages: 1627-1638.e6
- DOI
  10.1016/j.celrep.2018.07.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16KT0114, KAKENHI-PROJECT-18H02673, KAKENHI-PROJECT-17H06175, KAKENHI-PROJECT-20K20384
[Journal Article] Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy2017
- Author(s)
  Taisuke Kondo, Rimpei Morita, Yuumi Okuzono, Hiroko Nakatsukasa, Takashi Sekiya, Shunsuke Chikuma, Takashi Shichita, Mitsuhiro Kanamori, Masato Kubo, Keiko Koga, Takahiro Miyazaki, Yoshiaki Kassai, Akihiko Yohimura
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 15338-15338
- DOI
  10.1038/ncomms15338
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0114, KAKENHI-PROJECT-16K15292, KAKENHI-PROJECT-16H05178, KAKENHI-PROJECT-17H07088
[Journal Article] Improvement of Foxp3 stability through CNS2 demethylation by TET enzyme induction and activation2017
- Author(s)
  Someya Kazue、Nakatsukasa Hiroko、Ito Minako、Kondo Taisuke、Tateda Kenn-ichi、Akanuma Takashi、Koya Ikuko、Sanosaka Tsukasa、Kohyama Jun、Tsukada Yu-ichi、Takamura-Enya Takeji、Yoshimura Akihiko
- Journal Title
  
  International Immunology
  
  Volume: 29 Issue: 8 Pages: 365-375
- DOI
  10.1093/intimm/dxx049
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00562, KAKENHI-PROJECT-16K15292, KAKENHI-PROJECT-17K19398, KAKENHI-PLANNED-25112008, KAKENHI-PROJECT-17H07088, KAKENHI-PROJECT-15J03260, KAKENHI-PROJECT-15J07468
[Journal Article] Role of scavenger receptors as damage-associated molecular pattern receptors in Toll-like receptor activation.2017
- Author(s)
  2)Komai K, Shichita T, Ito M, Kanamori M, Chikuma S, Yoshimura A.
- Journal Title
  
  Int Immunol.
  
  Volume: in press Issue: 2 Pages: 59-70
- DOI
  10.1093/intimm/dxx010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01387, KAKENHI-PROJECT-25221305, KAKENHI-PROJECT-16K08847, KAKENHI-PROJECT-17K19571, KAKENHI-PUBLICLY-17H05514, KAKENHI-PROJECT-17H05096
[Journal Article] Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy2017
- Author(s)
  Taisuke Kondo, Rimpei Morita, Yuumi Okuzono, Hiroko Nakatsukasa, Takashi Sekiya, Shunsuke Chikuma, Takashi Shichita, Mitsuhiro Kanamori, Masato Kubo, Keiko Koga, Takahiro Miyazaki, Yoshiaki Kassai, Yoshimura Akihiko
- Journal Title
  
  Nature Communications
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K15292
[Journal Article] Mafb prevents excess inflammation after ischemic stroke by accelerating clearance of danger signals through MSR1.2017
- Author(s)
  1)Shichita T, Ito M, Morita R, Komai K, Noguchi Y, Ooboshi H, Koshida R, Takahashi S, Kodama T, Yoshimura A.
- Journal Title
  
  Nat Med.
  
  Volume: in press Issue: 6 Pages: 723-732
- DOI
  10.1038/nm.4312
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01387, KAKENHI-PROJECT-25221305, KAKENHI-PROJECT-16H05178, KAKENHI-PROJECT-26461301, KAKENHI-PROJECT-17K19571, KAKENHI-PUBLICLY-17H05514, KAKENHI-PROJECT-17H05096, KAKENHI-PROJECT-16H06276
[Journal Article] Interaction between a domain of a negative regulator of the RAS-ERK pathway, SPRED1, and the GTPase-Activating Protein-Related Domain of neurofibromin is implicated in Legius Syndrome and Neurofibromatosis Type 1.2016
- Author(s)
  Hirata Y, Brems H, Suzuki M, Kanamori M, Okada M, Morita R, Llano-Rivas I, Ose T, Messiaen L, Legius E, Yoshimura A.
- Journal Title
  
  J Biol Chem
  
  Volume: 291 Issue: 7 Pages: 3124-3134
- DOI
  10.1074/jbc.m115.703710
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221305
[Journal Article] TGF-β-induced phosphorylation of Akt and Foxo transcription factors negatively regulates induced regulatory T cell differentiation.2016
- Author(s)
  Kurebayashi Y, Baba Y, Minowa A, Nadya NA, Azuma M, Yoshimura A, Koyasu S, Nagai S.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 480 Issue: 1 Pages: 114-119
- DOI
  10.1016/j.bbrc.2016.09.153
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293400
[Journal Article] Adiponectin enhances antibacterial activity of hematopoietic cells by suppressing bone marrow inflammation.2016
- Author(s)
  Masamoto Y, Arai S, Sato T, Yoshimi A, Kubota N, Takamoto I, Iwakura Y, Yoshimura A, Kadowaki T, Kurokawa M
- Journal Title
  
  Immunity
  
  Volume: 44 Issue: 6 Pages: 1422-33
- DOI
  10.1016/j.immuni.2016.05.010
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01481, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-25221305, KAKENHI-PROJECT-16K15500, KAKENHI-PROJECT-26000012
[Journal Article] Induced Regulatory T Cells: Their Development, Stability, and Applications.2016
- Author(s)
  Kanamori M, Nakatsukasa H, Okada M, Lu Q, Yoshimura A.
- Journal Title
  
  Trends Immunol.
  
  Volume: 37 Issue: 11 Pages: 803-811
- DOI
  10.1016/j.it.2016.08.012
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221305, KAKENHI-PROJECT-15J03260, KAKENHI-PROJECT-15K19135
[Journal Article] Anti-IL-12/23 p40 antibody attenuates experimental chronic graft-versus-host disease via suppression of IFN-γ/IL-17-producing cells.2015
- Author(s)
  Okamoto S, Fujiwara H et al.
- Journal Title
  
  The Journal of Immunology
  
  Volume: 194 Issue: 3 Pages: 13571363-13571363
- DOI
  10.4049/jimmunol.1400973
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591424, KAKENHI-PROJECT-25221305, KAKENHI-PROJECT-26461449
[Journal Article] Bruton's tyrosine kinase is an essential component for NLRP3 inflammasome activation and a potential therapeutic target for ischemic brain injury2015
- Author(s)
  Ito M, Shichita T, Morita R, Yoshimura A
- Journal Title
  
  Nature Communications
  
  Volume: 未定
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25670234
[Journal Article] ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells.2015
- Author(s)
  Morita R, Suzuki M, Kasahara H, Shimizu N, Shichita T, Sekiya T, Kimura A, Sasaki K, Yasukawa H, Yoshimura A.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 112 Issue: 1 Pages: 160-165
- DOI
  10.1073/pnas.1413234112
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25221305, KAKENHI-PROJECT-25670233, KAKENHI-PROJECT-25670234, KAKENHI-PROJECT-26713019, KAKENHI-PROJECT-26461137, KAKENHI-PROJECT-26670470
[Journal Article] Innate-like function of memory Th17 cells for enhancing endotoxin-induced acute lung inflammation through IL-22.2015
- Author(s)
  Sakaguchi R, Chikuma S, Shichita T, Morita R, Sekiya T, Ouyang W, Ueda T, Seki H, Morisaki H, Yoshimura A
- Journal Title
  
  Int Immunol.
  
  Volume: 28 Issue: 5 Pages: 233-243
- DOI
  10.1093/intimm/dxv070
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01387, KAKENHI-PROJECT-13J01369, KAKENHI-PROJECT-26713019, KAKENHI-PROJECT-25221305, KAKENHI-PROJECT-16H05178
[Journal Article] Bruton’s tyrosine kinase (BTK) is an essential component for NLRP3 inflammasome activation and a potential therapeutic target for inflammation after ischemic brain injury.2015
- Author(s)
  Ito M, Shichita T, Okada M, Komine R, Noguchi Y, Yoshimura A, and Morita R.
- Journal Title
  
  Nat Commun.
  
  Volume: 6 Issue: 1 Pages: 7360-7360
- DOI
  10.1038/ncomms8360
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01387, KAKENHI-PROJECT-25221305
[Journal Article] Smad2 and Smad3 inversely regulate TGF-β autoinduction in Clostridium butyricum-activated dendritic cells.2015
- Author(s)
  Kashiwagi K, Morita R, Schichita T, Komai K, Saeki K, Matsumoto M, Takeda K, Nomura M, Hayashi A, Kanai T, Yoshimura A
- Journal Title
  
  Immunity
  
  Volume: 43 Issue: 1 Pages: 65-79
- DOI
  10.1016/j.immuni.2015.06.010
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461383, KAKENHI-PUBLICLY-15H01387, KAKENHI-PROJECT-26870571, KAKENHI-PROJECT-25221305
[Journal Article] Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells2015
- Author(s)
  Sekiya T, Kondo T, Shichita T, Morita R, Ichinose H, Yoshimura A
- Journal Title
  
  J Exp Med.
  
  Volume: 212 Issue: 10 Pages: 1623-1640
- DOI
  10.1084/jem.20142088
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01387, KAKENHI-PUBLICLY-15H01422, KAKENHI-PROJECT-14J07006, KAKENHI-PROJECT-26670470, KAKENHI-PROJECT-26870571, KAKENHI-PROJECT-26713019, KAKENHI-PROJECT-25221305
[Journal Article] A gp130-Src-YAP module links inflammation to epithelial regeneration.2015
- Author(s)
  Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M.
- Journal Title
  
  Nature
  
  Volume: 519 Issue: 7541 Pages: 57-62
- DOI
  10.1038/nature14228
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25221305, KAKENHI-PROJECT-25670234, KAKENHI-PROJECT-24390321
[Journal Article] Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and therapeutic target for ischemic brain injury2015
- Author(s)
  Ito M, Shichita T, Morita R, Yoshimura A
- Journal Title
  
  Nature communications
  
  Volume: 未定
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25221305
[Journal Article] Aryl hydrocarbon receptor protects against bacterial infection by promoting macrophage survival and reactive oxygen species production2014
- Author(s)
  Kimura A, Abe H, Tsuruta S, Chiba S, Fujii-Kuriyama Y, Sekiya T, Morita R, Yoshimura A.
- Journal Title
  
  Int Immunol.
  
  Volume: 26 Issue: 4 Pages: 209-220
- DOI
  10.1093/intimm/dxt067
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-24117718, KAKENHI-PROJECT-25670233, KAKENHI-PROJECT-25670234, KAKENHI-PROJECT-25860324, KAKENHI-PROJECT-26713019, KAKENHI-PROJECT-25221305
[Journal Article] Loss of Sprouty4 in T cells ameliorates experimental autoimmune encephalomyelitis in mice by negatively regulating IL-1β receptor expression.2014
- Author(s)
  Fukaya T, Someya K, Hibino S, Okada M, Yamane H, Taniguchi K, Yoshimura A.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 447 Issue: 3 Pages: 471-478
- DOI
  10.1016/j.bbrc.2014.04.012
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25221305
[Journal Article] Aryl hydrocarbon receptor plays protective roles in ConA-induced hepatic injury by both suppressing IFN-Y expression and inducing IL-222014
- Author(s)
  Abe H, Kimura A, Tsuruta S, Fukaya T, Sakaguchi R, et al.
- Journal Title
  
  Int Immunol.
  
  Volume: 26 Issue: 3 Pages: 129-137
- DOI
  10.1093/intimm/dxt049
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-12J08459, KAKENHI-PUBLICLY-24117718, KAKENHI-PROJECT-25670233, KAKENHI-PROJECT-25670234, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-25221305
[Journal Article] Prevention of allogeneic cardiac graft rejection by transfer of ex vivo expanded antigen-specific regulatory T-cells.2014
- Author(s)
  Takasato F, Morita R, Schichita T, Sekiya T, Morikawa Y, Kuroda T, Niimi M, Yoshimura A.
- Journal Title
  
  PLoS One.
  
  Volume: 9(2) Issue: 2 Pages: e87722-e87722
- DOI
  10.1371/journal.pone.0087722
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21249085, KAKENHI-PROJECT-25670234, KAKENHI-PROJECT-25221305
[Journal Article] IL-23-Independent Induction of IL-17 from γδT Cells and Innate Lymphoid Cells Promotes Experimental Intraocular Neovascularization2013
- Author(s)
  Hasegawa E, Sonoda KH, Shichita T, Morita R, Sekiya T, Kimura A, Oshima Y, Takeda A, Yoshimura T, Yoshida S, Ishibashi T, Yoshimura A
- Journal Title
  
  J Immunol
  
  Volume: 190(4) Pages: 1778-87
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659242
[Journal Article] IL-23-Independent Induction of IL-17 from γδTCells and Innate Lymphoid Cells PromotesExperimental Intraocular Neovascularization2013
- Author(s)
  Hasegawa E, Sonoda KH, Shichita T, Morita R,Sekiya T, Kimura A, Oshima Y, Takeda A,Yoshimura T, Yoshida S, Ishibashi T, Yoshimura A.
- Journal Title
  
  JImmunol.
  
  Volume: 190(4) Pages: 1778-87
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249009
[Journal Article] Nr4a receptors areessential for thymic regulatory T cell developmentand immune homeostasis.2013
- Author(s)
  Sekiya T, Kashiwagi I, Yoshida R, Fukaya T,Morita R, Kimura A, Ichinose H, Metzger D,Chambon P, Yoshimura A
- Journal Title
  
  Nature Immunol.
  
  Volume: 14(3) Pages: 230-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249009
[Journal Article] CDK inhibitors suppress Th17 and promote iTreg differentiation, and ameliorate experimental autoimmune encephalomyelitis in mice.2013
- Author(s)
  Yoshida H, Kotani H, Kondo T, Tani I, Wei X, Tsuruta S, Kimura A, Asakawa M, Ito M, Nagai S, Yoshimura A.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 435 Issue: 3 Pages: 378-384
- DOI
  10.1016/j.bbrc.2013.04.096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790479, KAKENHI-PROJECT-25460132
[Journal Article] TRAF6 Is Essential for Maintenance of Regulatory T Cells That Suppress Th2 Type Autoimmunity.2013
- Author(s)
  Muto G, Kotani H, Kondo T, Morita R, Tsuruta S, Kobayashi, T., Luche H, Fehling HJ, Walsh M, Choi Y, Yoshimura A.
- Journal Title
  
  PLoS One
  
  Volume: 8 (9) Issue: 9 Pages: e74639-e74639
- DOI
  10.1371/journal.pone.0074639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590573, KAKENHI-PUBLICLY-24117718, KAKENHI-PROJECT-25460132, KAKENHI-PROJECT-25670234
[Journal Article] Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis2013
- Author(s)
  Sekiya T, Kashiwagi I, Yoshida R, Fukaya T, Morita R, Kimura A, Ichinose H, Metzger D, Chambon P, Yoshimura A
- Journal Title
  
  Nature Immunol
  
  Volume: 14(3) Pages: 230-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659242
[Journal Article] protein-2 modulates fas-mediated T cell apoptosisby interacting with caspase-82012
- Author(s)
  Sekine Y, Yamamoto C, Kakisaka M, MuromotoR, Kon S, Ashitomi D, Fujita N, Yoshimura A,Oritani K, Matsuda T. Signal-transducing adap
- Journal Title
  
  J Immunol
  
  Volume: 188(12) Pages: 6194-204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249009
[Journal Article] CCL2-Induced Migration andSOCS3-Mediated Activation of Macrophages AreInvolved in Cerulein-Induced Pancreatitis in Mice2012
- Author(s)
  Saeki K, Kanai T, Nakano M, Nakamura Y,Miyata N, Sujino T, Yamagishi Y, Ebinuma H,Takaishi H, Ono Y, Takeda K, Hozawa S,Yoshimura A, Hibi T
- Journal Title
  
  Gastroenterology
  
  Volume: 142(4) Pages: 1010-1020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249009
[Journal Article] Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation.2012
- Author(s)
  Yoshida H, Kimura A, Fukaya T, Sekiya T, Morita R, Shichita T, Inoue H, Yoshimura A
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 418(2) Pages: 234-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659242
[Journal Article] Preferential induction of Th17 cells in vitro and in vivo by Fucogalactan from Ganoderma lucidum (Reishi)2012
- Author(s)
  Yoshida H, Suzuki M, Sakaguchi R, Tani I, Kotani H, Shudo N, Yoshimura A
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 422(1) Pages: 174-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659242
[Journal Article] Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain2012
- Author(s)
  Shichita T, Hasegawa E, Kimura A, MoritaR, Sakaguchi R, Takada I, Sekiya T, Ooboshi H, Kitazono T, Yanagawa T, Ishii T, Takahashi H, Mori S, Nishibori M, Kuroda K, Akira S, Miyake K, and Yoshimura A
- Journal Title
  
  Nature Medicine
  
  Volume: 18(6) Pages: 977-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659242
[Journal Article] Smad2 and Smad3 are redundantlyessential for the suppression of iNOS synthesis inmacrophages by regulating IRF3 and STAT1pathways.2012
- Author(s)
  Sugiyama Y, Kakoi K, Kimura A, Takada I,Kashiwagi I, Wakabayashi Y, Morita R, Nomura M,Yoshimura A
- Journal Title
  
  Int Immunol.
  
  Volume: 24(4) Pages: 253-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249009
[Journal Article] Peroxiredoxin familyproteins are key initiators of post-ischemicinflammation in the brain2012
- Author(s)
  Shichita T, Hasegawa E, Kimura A, MoritaR,Sakaguchi R, Takada I, Sekiya T, Ooboshi H,Kitazono T, Yanagawa T, Ishii T, TakahashiH, Mori S, Nishibori M, Kuroda K, Akira S,Miyake K, and Yoshimura A
- Journal Title
  
  Nature Medicine
  
  Volume: 18(6) Pages: 911-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249009
[Journal Article] Smad2 and Smad3 are redundantly essential for the suppression of iNOS synthesis in macrophages by regulating IRF3 and STAT1 pathways.2012
- Author(s)
  Sugiyama Y, Kakoi K, Kimura A, Takada I, Kashiwagi I, Wakabayashi Y, Morita R, Nomura M, Yoshimura A
- Journal Title
  
  Int Immunol
  
  Volume: 24(4) Pages: 253-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659242
[Journal Article] Histone 3 lysine 9 (H3K9) methyltransferaserecruitment to the interleukin-2 (IL-2) promoter isa mechanism of suppression of IL-2 transcriptionby the transforming growth factor-β-Smadpathway.2011
- Author(s)
  Wakabayashi Y, Tamiya T, Takada I, Fukaya T,Sugiyama Y, Inoue N, Kimura A, Morita R,Kashiwagi I, Takimoto T, Nomura M, YoshimuraA.
- Journal Title
  
  J Biol Chem.
  
  Volume: 286(41) Pages: 35456-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249009
[Journal Article] Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17.2011
- Author(s)
  Nakagawa R, Yoshida H, Asakawa M, Tamiya T, Inoue N, Morita R, Inoue H, Nakao A, Yoshimura A
- Journal Title
  
  J Immunol
  
  Volume: 187(9) Pages: 4611-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659242
[Journal Article] Desmoglein 3-specific CD4+ T cellsinduce pemphigus vulgaris and interfacedermatitis in mice.2011
- Author(s)
  Takahashi H, Kouno M, Nagao K, Wada N,Hata T, Nishimoto S, Iwakura Y, Yoshimura A,Yamada T, Kuwana M, Fujii H, Koyasu S,Amagai M
- Journal Title
  
  J Clin Invest
  
  Volume: 121(9) Pages: 3677-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249009
[Journal Article] Transcription Factor Smad-Independent T Helper 17 Cell Induction by Transforming-Growth Factor-ss Is Mediated by Suppression of Eomesodermin2011
- Author(s)
  Kenji Ichiyama, 他
- Journal Title
  
  Immunity
  
  Volume: 34 Issue: 5 Pages: 741-754
- DOI
  10.1016/j.immuni.2011.02.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J05327, KAKENHI-PROJECT-11J02842, KAKENHI-PROJECT-11J04861, KAKENHI-PROJECT-22249009, KAKENHI-PROJECT-22590438, KAKENHI-PROJECT-23659242, KAKENHI-PROJECT-23790545
[Journal Article] miR126 positivelyregulates mast cell proliferation and cytokineproduction through suppressing Spred12011
- Author(s)
  Ishizaki T, Tamiya T, Taniguchi K, Morita R,Kato R, Okamoto F, Saeki K, Nomura M,Nojima Y, Yoshimura A.
- Journal Title
  
  GenesCells.
  
  Volume: 16(7) Pages: 803-814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249009
[Journal Article] Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th172011
- Author(s)
  Ryusuke Nakagawa, 他
- Journal Title
  
  Journal of Immunology
  
  Volume: 187 Issue: 9 Pages: 4611-4620
- DOI
  10.4049/jimmunol.1100649
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-09J10943, KAKENHI-PROJECT-22249009, KAKENHI-PROJECT-22390167, KAKENHI-PROJECT-22590438, KAKENHI-PROJECT-23659435
[Journal Article]2011
- Author(s)
  Chinen T, Komai K, Muto G, Morita R, Inoue N, Yoshida H, Sekiya T, Yoshida R, Nakamura K, Takayanagi R, Yoshimura A
- Journal Title
  
  Nature Commun. 2
  
  Pages: 190-190
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] Transcription Factor Smad-Independent T Helper 17 Cell Induction by Transforming-Growth Factor-β Is Mediated by Suppression of Eomesodermin2011
- Author(s)
  Ichiyama K, Sekiya T, Inoue N, Tamiya T, Kashiwagi I, Kimura A, Morita R, Muto G, Shichita T, Takahashi R, Yoshimura A
- Journal Title
  
  Immunity
  
  Volume: 34(5) Pages: 741-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659242
[Journal Article] SOCS1 is essential forregulatory T cell functions by preventing loss ofFoxp3 expression as well as IFN-{gamma} andIL-17A production.2011
- Author(s)
  Takahashi R, Nishimoto S, Muto G, Sekiya T,Tamiya T, Kimura A, Morita R, Asakawa M,Chinen T, Yoshimura A.
- Journal Title
  
  J Exp Med
  
  Volume: 208(10) Pages: 2055-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249009
[Journal Article] The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells2011
- Author(s)
  Sekiya, T., et al
- Journal Title
  
  Nature Communications
  
  Volume: 2 Issue: 1 Pages: 269-269
- DOI
  10.1038/ncomms1272
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059014, KAKENHI-PROJECT-21500305, KAKENHI-PROJECT-22249009, KAKENHI-PROJECT-22590438, KAKENHI-PROJECT-23790346, KAKENHI-PROJECT-23390123
[Journal Article] The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4(+) T cells.2011
- Author(s)
  Sekiya T, Kashiwagi I, Inoue N, Yoshimura A, et al.
- Journal Title
  
  Nature Communications
  
  Volume: 2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249009
[Journal Article] Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance.2011
- Author(s)
  Chinen T, Komai K, Muto G Yoshimura A, et al.
- Journal Title
  
  Nature Communications
  
  Volume: 2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249009
[Journal Article] Histone 3 lysine 9 (H3K methyltransferase recruitment to the interleukin-2 (IL- promoter is a mechanism of suppression of IL-2 transcription by the transforming growth factor-β-Smad pathway.2011
- Author(s)
  Wakabayashi Y, Tamiya T, Takada I, Fukaya T, Sugiyama Y, Inoue N, Kimura A, Morita R, Kashiwagi I, Takimoto T, Nomura M, Yoshimura A
- Journal Title
  
  J Biol Chem
  
  Volume: 286(41) Pages: 35456-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659242
[Journal Article] 1,25-dihydroxyvitamin D(3) ameliorates Th17autoimmunity via transcriptional modulation ofinterleukin-17A2011
- Author(s)
  Joshi S, Pantalena LC, Liu XK, Gaffen SL, LiuH, Rohowsky-Kochan C, Ichiyama K, YoshimuraA, Steinman L, Christakos S, Youssef S
- Journal Title
  
  Mol Cell Biol.
  
  Volume: 31(17) Pages: 3653-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249009
[Journal Article] Effects of a Janus kinase inhibitor, pyridone 6, on airway responses in a murine model of asthma2011
- Author(s)
  Matsunaga Y, Inoue H, Fukuyama S, Yoshida H, Moriwaki A, Matsumoto T, Matsumoto K, Asai Y, Kubo M, Yoshimura A, Nakanishi Y
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 404(1) Pages: 261-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659242
[Journal Article] IL-1β and TNFα-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis.2011
- Author(s)
  Mori T, Miyamoto T, Yoshida H, Asakawa M, Kawasumi M, Kobayashi T, Morioka H, Chiba K, Toyama Y, Yoshimura A
- Journal Title
  
  Int Immunol
  
  Volume: 23(11) Pages: 701-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659242
[Journal Article] Pyridone 6, a pan-JAK inhibitor,ameliorates allergic skin inflammation of NC/Ngamice via suppression of Th2 and enhancement ofTh17.2011
- Author(s)
  Nakagawa R, Yoshida H, Asakawa M, TamiyaT, Inoue N, Morita R, Inoue H, Nakao A,Yoshimura A.
- Journal Title
  
  J Immunol.
  
  Volume: 187(9) Pages: 4611-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249009
[Journal Article] Transcription Factor Smad-Independent T Helper 17 Cell Inductionby Transforming-Growth Factor-β Is Mediatedby Suppression of Eomesodermin2011
- Author(s)
  Ichiyama K, Sekiya T, Inoue N, Tamiya T,Kashiwagi I, Kimura A, Morita R, Muto G, ShichitaT, Takahashi R, Yoshimura A.
- Journal Title
  
  Immunity
  
  Volume: 27;34(5) Pages: 741-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249009
[Journal Article] Smad2 and Smad3 are redundantly essential forthe TGF-beta-mediated regulation of regulatoryT plasticity and Th1 development.2010
- Author(s)
  Takimoto T, Wakabayashi Y, Sekiya T, InoueN, Morita R, Ichiyama K, Takahashi R,Asakawa M, Muto G, Mori T, Hasegawa E,Shizuya S, Hara T, Nomura M, Yoshimura A
- Journal Title
  
  J Immunol.
  
  Volume: 185(2) Pages: 842-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249009
[Journal Article] Smad2 and Smad3 are redundantly essential for the TGF-beta-mediated regulation of regulatory T plasticity and Th1 development.2010
- Author(s)
  Takimoto T, Wakabayashi Y, Sekiya T, Inoue N, Morita R, Ichiyama K, Takahashi R, Asakawa M, Muto G, Mori T, Hasegawa E, Shizuya S, Hara T, Nomura M, Yoshimura A
- Journal Title
  
  J Immunol. 185(2)
  
  Pages: 842-55
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses.2010
- Author(s)
  Lu LF, Boldin MP, Chaudhry A, Lin LL, Taganov KD, Hanada T, Yoshimura A, Baltimore D, Rudensky AY
- Journal Title
  
  Cell. 142(6)
  
  Pages: 914-29
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] Suppressors of cytokinesignaling 3 inhibits LPS-induced IL-6 expressionin osteoblasts by suppressingCCAAT/enhancer-binding protein {beta} activity2010
- Author(s)
  Yan C, Cao J, Wu M, Zhang W, Jiang T,Yoshimura A, Gao H.
- Journal Title
  
  J Biol Chem.
  
  Volume: 285(48) Pages: 37227-39
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249009
[Journal Article] Function ofmiR-146a in controlling Treg cell-mediatedregulation of Th1 responses.2010
- Author(s)
  Lu LF, Boldin MP, Chaudhry A, Lin LL,Taganov KD, Hanada T, Yoshimura A,Baltimore D, Rudensky AY
- Journal Title
  
  Cell.
  
  Volume: 142(6) Pages: 914-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249009
[Journal Article] Smad2 and Smad3 are redundantly essential for the TGF-beta-mediated regulation of regulatory T plasticity and Th1 development.2010
- Author(s)
  Takimoto T, Wakabayashi Y, Sekiya T, Yoshimura A, et al
- Journal Title
  
  J Immunol.
  
  Volume: 185(7) Pages: 842-855
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249009
[Journal Article] Suppression of Sproutys has a therapeutic effect for a mouse model of ischemia by enhancing angiogenesis.2009
- Author(s)
  Taniguchi K, Sasaki K, Watari K, Yasukawa H, Imaizumi T, Ayada T, Okamoto F, Ishizaki T, Kato R, Kohno R, Kimura H, Sato Y, Ono M, Yonemitsu Y, Yoshimura A
- Journal Title
  
  PLoS ONE 4(5)
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Sprouty4 negatively regulates protein kinase C activation by inhibiting phosphatidylinositol 4, 5-biphosphate hydrolysis.2009
- Author(s)
  Ayada T, Taniguchi K, Okamoto F, Kato R, Komune S, Takaesu G, Yoshimura A
- Journal Title
  
  Oncogene 28(8)
  
  Pages: 1076-88
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis.2009
- Author(s)
  Taleb S, Romain M, Ramkhelawon B, Uyttenhove C, Pasterkamp G, Herbin O, Esposito B, Perez N, Yasukawa H, Van Snick J, Yoshimura A, Tedgui A, Mallat Z
- Journal Title
  
  J Exp Med. 206(10)
  
  Pages: 2067-77
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] Rudensky AY. Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein.2009
- Author(s)
  Lu LF, Thai TH, Calado DP, Chaudhry A, Kubo M, Tanaka K, Loeb GB, Lee H, Yoshimura A, Rajewsky K
- Journal Title
  
  Immunity 30(1)
  
  Pages: 80-91
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Rajewsky K, Rudensky AY. Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein2009
- Author(s)
  Lu LF, Thai TH, Calado DP, Chaudhry A, Kubo M, Tanaka K, Loeb GB, Lee H, Yoshimura A
- Journal Title
  
  Immunity 30(1)
  
  Pages: 80-91
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the c-Fos protein phosphorylated by IKKbeta2009
- Author(s)
  Koga K, Takaesu G, Yoshida R, Nakaya M, Kobayashi T, Kinjyo I, Yoshimura A
- Journal Title
  
  Immunity 30(3)
  
  Pages: 372-383
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury.2009
- Author(s)
  Shichita T, Sugiyama Y, Ooboshi H, Sugimori H, Nakagawa R, Takada I, Iwaki T, Okada Y, Iida M, Cua DJ, Iwakura Y, Yoshimura A
- Journal Title
  
  Nature Med. 15(8)
  
  Pages: 946-950
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein.2009
- Author(s)
  Lu LF, Thai TH, Calado DP, ChaudhryA, Kubo M, Tanaka K, Loeb GB, Lee H, Yoshimura A, Rajewsky K, Rudensky AY
- Journal Title
  
  Immunity. 30(1)
  
  Pages: 80-91
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] Silencing of SOCS1 in macrophages suppresses tumor development by enhancing antitumor inflammation2009
- Author(s)
  Hashimoto M, Ayada T, Kinjyo I, Hiwatashi K, Yoshida H, Okada Y Kobayashi T, Yoshimura A
- Journal Title
  
  Cancer Sci 100(4)
  
  Pages: 730-736
- NAID
  10025144745
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the c-Fos protein phosphorylated by IKKbeta2009
- Author(s)
  Koga K, Takaesu G, Yoshida R, Nakaya M, Kobayashi T, Kinjyo I, Yoshimura A
- Journal Title
  
  Immunity 30(3)
  
  Pages: 372-383
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Clinical and mutational spectrum of Legius syndrome2009
- Author(s)
  Messiaen L, Yao S, 他, Taniguchi K, Ayada T, Okamoto F, Yoshimura A, Parret A, Korf B, Legius E
- Journal Title
  
  JAMA. 302(19)
  
  Pages: 2111-8
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] Pivotalrole of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury.2009
- Author(s)
  Shichita T, Sugiyama Y, Ooboshi H, Sugimori H, Nakagawa R, Takada I, Iwaki T, Okada Y, Iida M, Cua DJ, Iwakura Y, Yoshimura A
- Journal Title
  
  Nature Med. 15(8)
  
  Pages: 946-50
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] SOCS3 in T and NKT cells negatively regulates cytokine production and ameliorates ConA-induced hepatitis.2009
- Author(s)
  Nakaya M, Hashimoto M, Nakagawa R, Wakabayashi Y, Ishizaki T, Takada I, Komai K, Yoshida H, Yoshimura A
- Journal Title
  
  J Immunol. 183(11)
  
  Pages: 7047-53
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] SOCS3 in T and NKT cells negatively regulates cytokine production and ameliorates ConA-induced hepatitis.2009
- Author(s)
  Nakaya M, Hashimoto M, Nakagawa R, Wakabayashi Y, Ishizaki T, Takada I, Komai K, Yoshida H, Yoshimura A
- Journal Title
  
  J Immunol 183(11)
  
  Pages: 7047-7053
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Clinical and mutational spectrum of Legius syndrome2009
- Author(s)
  Messiaen L, Yao S, (他30名), Taniguchi K, Ayada T, Okamoto F, Yoshimura A, Parret A, Korf B, Legius E
- Journal Title
  
  JAMA 302(19)
  
  Pages: 2111-2118
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis.2009
- Author(s)
  Taleb S, Romain M, Ramkhelawon B, Uyttenhove C, Pasterkamp G, Herbin O, Esposito B, Perez N, Yasukawa H, Van Snick J, Yoshimura A, Tedgui A, Mallat Z
- Journal Title
  
  J Exp Med. 206(10)
  
  Pages: 2067-2077
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Suppression of Sproutys has a therapeutic effect for a mouse model of ischemia by enhancing angiogenesis.2009
- Author(s)
  Taniguchi K, Sasaki K, Watari K, Yasukawa H, Imaizumi T, Ayada T, Okamoto F, Ishizaki T, Kato R, Kohno R, Kimura H, Sato Y, Ono M, Yonemitsu Y, Yoshimura A
- Journal Title
  
  PLoS ONE. 4(5)
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the c-Fos protein phosphorylated by IKKbeta2009
- Author(s)
  Koga K, Takaesu G, Yoshida R, Nakaya M, Kobayashi T, Kinjyo I, Yoshimura A
- Journal Title
  
  Immunity. 30(3)
  
  Pages: 372-383
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-{gamma} on STAT3 and Smads.2008
- Author(s)
  Tanaka K, Ichiyama K, Hashimoto M, Yoshida H, Takimoto T, Takaesu G, Torisu T, Hanada T, Yasukawa H, Fukuyama S, Inoue H, Nakanishi Y, Kobayashi T, Yoshimura A
- Journal Title
  
  J Immunol. 180(6)
  
  Pages: 3746-56
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN{gamma} on STAT3 and Smads.2008
- Author(s)
  Tanaka K, Kobayashi T, Yoshimura A, et. al.
- Journal Title
  
  J Immunol. 180
  
  Pages: 1-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-{gamma} on STAT3 and Smads.2008
- Author(s)
  Tanaka K, Ichiyama K, Hashimoto M, Yoshida H, Takimoto T, Takaesu G, Torisu T, Hanada T, Yasukawa H, Fukuyama S, Inoue H, Nakanishi Y, Kobayashi T, Yoshimura A
- Journal Title
  
  J Immunol 180(6)
  
  Pages: 3746-3756
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Suppressor of cytokine signaling 1 protects mice against concanavalin A-induced hepatitis by inhibiting apoptosis.2008
- Author(s)
  Torisu T, Nakaya M, Watanabe S, Hashimoto M, Yoshida H, Chinen T, Yoshida R, Okamoto F, Hanada T, Torisu K, Takaesu G, Kobayashi T, Yasukawa H, Yoshimura A
- Journal Title
  
  Hepatology 47(5)
  
  Pages: 1644-1654
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag.2008
- Author(s)
  Ryo A, Tsurutani N, Ohba K, Kimura R, Komano J, Nishi M, Soeda H, Hattori S, Perrem K, Yamamoto M, Chiba J, Mimaya J, Yoshimura K, Matsushita S, Honda M, Yoshimura A, Sawasaki T, Aoki I, Morikawa Y, Yamamoto N
- Journal Title
  
  Proc Natl Acad Sci U S A 105(1)
  
  Pages: 294-299
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] TRAF6 and MEKK1 Play a Pivotal Role in the RIG-I-like Helicase Antiviral Pathway.2008
- Author(s)
  Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
- Journal Title
  
  J Biol Chem. 283(52)
  
  Pages: 36211-36220
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] STAT6 inhibits TGF-beta 1-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor.2008
- Author(s)
  Takaki H, Ichiyama K, Koga K, Chinen T, Takaesu G, Sugiyama Y, Kato S, Yoshimura A, Kobayashi T
- Journal Title
  
  J Biol Chem. 283(22)
  
  Pages: 14955-62
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-{gamma} on STAT3 and Smads.2008
- Author(s)
  Tanaka K, Takimoto T, Yoshimura A, Kobayashi T., et al.
- Journal Title
  
  J Immunol. 180
  
  Pages: 3746-3756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659077
[Journal Article] STAT6 inhibits TGF-beta 1-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor.2008
- Author(s)
  Takaki H, Ichiyama K, Koga K, Chinen T, Takaesu G, Sugiyama Y, Kato S, Yoshimura A, Kobayashi T
- Journal Title
  
  J Biol Chem. 283(22)
  
  Pages: 14955-14962
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicases signaling pathway.2008
- Author(s)
  Sanada T, Takaesu G, Mashima R, Yoshida R, Kobayashi T, Yoshimura A
- Journal Title
  
  J Biol Chem. 283(49)
  
  Pages: 33858-33864
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-{gamma} on STAT3 and Smads.2008
- Author(s)
  Tanaka, K・Kobayashi, T・Yoshimura, A, et. al.
- Journal Title
  
  J Immunol. 180
  
  Pages: 3746-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellualt trafficking and stability of HIV-1 Gag.2008
- Author(s)
  Ryo, A・Yoshimura, A・Aoki, I・Morikawa, Y・Yamamoto, N., et. al.
- Journal Title
  
  Porc Natl Acad Sci USA. 105
  
  Pages: 294-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag2008
- Author(s)
  Ryo A, Yoshimura A, Aoki I, Morikawa Y, Yamamoto N., et. al.
- Journal Title
  
  Proc Natl Acad Sci U S A. 105
  
  Pages: 294-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor recrptor 3 signaling.2007
- Author(s)
  Taniguchi K, Maehara Y, Yoshimura A, et. al.
- Journal Title
  
  Mol Cell Biol. 27
  
  Pages: 4541-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] SOCS proteins, cytokine signalling and immune regulation.2007
- Author(s)
  Yoshimura A, Naka T, Kubo M
- Journal Title
  
  Nat Rev Immunol 7(6)
  
  Pages: 454-465
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] SOCS proteins, cytokine signalling and immune regulation.2007
- Author(s)
  Yoshimura A, Naka T, Kubo M
- Journal Title
  
  Nat Rev Immunol. 7(6)
  
  Pages: 454-65
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype.2007
- Author(s)
  Brems H, Chmara M, Sahbatou M, Denayer E, Taniguchi K, Kato R, Somers R, Messiaen L, De Schepper S, Fryns JP, Cools J, Marynen P, Thomas G, Yoshimura A, Legius E
- Journal Title
  
  Nature Genet 39(9)
  
  Pages: 1120-1126
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] SOCS proteins, cytokine signalling and immune regulation2007
- Author(s)
  Yoshimura A, Naka T, Kubo M.
- Journal Title
  
  Nat Rev Immunol. 7
  
  Pages: 454-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] SOCS3 Protein Developmentally Regulates the Chemokine Receptoe CXC R4-FAK Signaling Pathway during B Lymphopoiesis2007
- Author(s)
  Le Y, Yoshimura A, Silberstein LE, et. al.
- Journal Title
  
  Immunity. 27
  
  Pages: 811-823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] Selective expansion of fox3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient demdritic cells2007
- Author(s)
  Matsumura Y, Wyss-Coray T, Sato K, Yoshimura A, et. al.
- Journal Title
  
  J Imunol. 179
  
  Pages: 2170-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] SOCS proteins, cytokine signalling and immune regulation.2007
- Author(s)
  Yoshimura, A・Naka, T・Kubo, M
- Journal Title
  
  Nat Rev Immunol. 7
  
  Pages: 454-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype.2007
- Author(s)
  Brems H, Chmara M, Sahbatou M, Denayer E, Taniguchi K, Kato R, Somers R, Messiaen L, De Schepper S, Fryns JP, Cools J, Marynen P, Thomas G, Yoshimura A, Legius E
- Journal Title
  
  Nature Genet. 39(9)
  
  Pages: 1120-6
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] SOCS3 Protein Developmentally Regulates the Chemokine Receptor CXCR4-FAK Signaling Pathway during B Lymphopoiesis.2007
- Author(s)
  Le, Y・Yoshimura, A・Silberstein, LE, et. al.
- Journal Title
  
  Immunity. 27
  
  Pages: 811-823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling.2007
- Author(s)
  Taniguchi, K・Maehara, Y・Yoshimura, A., et. al.
- Journal Title
  
  Mol Cell Biol 27
  
  Pages: 4541-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling.2007
- Author(s)
  Taniguchi K, Kohno R, Ayada T, Kato R, Ichiyama K, Morisada T, Oike Y, Yonemitsu Y, Maehara Y, Yoshimura A
- Journal Title
  
  Mol Cell Biol. 27(12)
  
  Pages: 4541-4550
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Germline loss-of-function mutations in SPRED1 cause a neuofibromatosis 1-like phenotype.2007
- Author(s)
  Brems, H・Marynen, P・Thomas, G・Yoshimura, A・Legius, E, et. al.
- Journal Title
  
  Nature Genet. 39
  
  Pages: 1120-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype.2007
- Author(s)
  Brems H, Marunen P, Thomas G, Yoshimura A, Legius E, et. al.
- Journal Title
  
  Nature Genet. 39
  
  Pages: 1120-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokin signaling 3-deficient dendritic cells.2007
- Author(s)
  Matsumura, Y・Wyss-Coray, T・Sato, K・Yoshimura, A, et. al.
- Journal Title
  
  J Immunol. 179
  
  Pages: 2170-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling.2007
- Author(s)
  Taniguchi K, Ayada T, Ichiyama K, Yoshimura A, et al.
- Journal Title
  
  Biochem Biophys Res Commun. 352(4)
  
  Pages: 896-902
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Suppressor of Cytokine Signaling-1 Regulates Inflammatory Bowel Disease in Which Both IFNgamma and IL-4 Are Involved.2006
- Author(s)
  Chinen T, kobatashi T, Ogata H, Yoshimura A, et al.
- Journal Title
  
  Gastroenterology. 130(2)
  
  Pages: 373-88
- Data Source
  KAKENHI-PROJECT-13GS0011
[Journal Article] Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis.2006
- Author(s)
  Ogata H, Kobayashi T, Chinen T, Takaki H, Sanada T, Minoda Y, Koga K, Takaesu G, Maehara Y, Iida M, Yoshimura A
- Journal Title
  
  Gastroenterology 131(1)
  
  Pages: 179-193
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury.2006
- Author(s)
  Okada S, Nakamura M, Katoh H, Miyao T, Shimazaki T, Ishii K, Yamane J, Yoshimura A, Iwamoto Y, Toyama Y, Okano H
- Journal Title
  
  Nature Med. 12(7)
  
  Pages: 829-834
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] TGF-beta1 suppresses IFN-gamma-induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation.2006
- Author(s)
  Takaki H, Minoda Y, Yoshimura A, Kobayashi T, et al.
- Journal Title
  
  Genes Cells. 11(8)
  
  Pages: 871-882
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice.2006
- Author(s)
  Hanada T, Kobayashi T, Chinen T, Saeki K, Yoshimura A, et al.
- Journal Title
  
  J Exp Med. 203(6)
  
  Pages: 1391-1397
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice.2006
- Author(s)
  Hanada T, Kobayashi T, Chinen T, Saeki K, Takaki H, Koga K, Minoda Y, Sanada T, Yoshioka T, Mimata H, Kato S, Yoshimura A
- Journal Title
  
  J Exp Med. 203(6)
  
  Pages: 1391-1397
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis.2006
- Author(s)
  Ogata H, Kobayashi T, Chinen T, Takaki H, Yoshimura A, et al.
- Journal Title
  
  Gastroenterology. 131(1)
  
  Pages: 179-193
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-betal production.2006
- Author(s)
  Ogata H, Chinen T, Yoshida T, Yoshimura A, et al.
- Journal Title
  
  Oncogene. (in press)
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1.2006
- Author(s)
  Kinjyo I, Inoue H, Hamano S, Fukuyama S, Yoshimura T, Koga K, Takaki H, Himeno K, Takaesu G, Kobayashi T, Yoshimura A
- Journal Title
  
  J Exp Med. 203(4)
  
  Pages: 1021-1031
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice.2006
- Author(s)
  Hanada T, Kobayashi T, Chinen T, Saeki K, Yoshimura A, et al.
- Journal Title
  
  J Exp Med. 203(6)
  
  Pages: 1391-7
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system.2006
- Author(s)
  Stumhofer JS, Laurence A, Yoshimura A, Hunter CA, et al.
- Journal Title
  
  Nat Immunol. 7(9)
  
  Pages: 937-45
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta1 production.2006
- Author(s)
  Ogata H, Chinen T, Yoshida T, Kinjyo I, Takaesu G, Shiraishi H, Iida M, Kobayashi T, Yoshimura A
- Journal Title
  
  Oncogene 25(17)
  
  Pages: 2520-2530
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Suppressor of Cytokine Signaling-1 Regulates Inflammatory Bowel Disease in Which Both IFNgamma and IL-4 Are Involved.2006
- Author(s)
  Chinen T, Kobayashi T, Ogata H, Yoshimura A, et al.
- Journal Title
  
  Gastroenterology. 130(2)
  
  Pages: 373-388
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 12006
- Author(s)
  Kinjyo I, Inoue H, Hamano S, Fukuyama S, Yoshimura T, Koga K, Takaki H, Himeno K, Takaesu G, Kobayashi T, Yoshimura A
- Journal Title
  
  J Exp Med 203(4)
  
  Pages: 1021-1031
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1.2006
- Author(s)
  Kinjyo I, Inoue H, Hamano S, Yoshimura A, et al.
- Journal Title
  
  J Exp Med. 203(4)
  
  Pages: 1021-31
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] Suppressor of cytokine signalling 1 in lymphocytes regulates the development of intestinal inflammation in mice.2006
- Author(s)
  Inagaki-Ohara K, Sasaki A, Matsuzaki G, Yoshimura A, et al.
- Journal Title
  
  Gut. 55(2)
  
  Pages: 212-219
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Two-sided roles of IL-27 : induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism.2006
- Author(s)
  Yoshimura T, Takeda A, Yoshimura A, Yoshida H, et al.
- Journal Title
  
  J Immunol. 177(8)
  
  Pages: 5277-85
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic.2006
- Author(s)
  Lu Y, Fukuyama S, Yoshida R, Yoshimura A, Takaesu G, et al.
- Journal Title
  
  J Biol Chem. 281(48)
  
  Pages: 36683-36690
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells.2006
- Author(s)
  Chen Z, Laurence A, Kanno Y, Yoshimura A, O'Shea JJ, et al.
- Journal Title
  
  Proc Natl Acad Sci USA. 103(21)
  
  Pages: 8137-42
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] Innate defense mechanism against virus infection within the cardiac myocyte requiring gp130-STAT3 signaling.2006
- Author(s)
  Yajima T, Yoshimura A, Knowlton KU, et al.
- Journal Title
  
  Circulation. 114(22)
  
  Pages: 2364-73
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice2006
- Author(s)
  Hanada T, Kobayashi T, Chinen T, Saeki K, Takaki H, Koga K, Minoda Y, Sanada T, Yoshioka T, Mimata H, Kato S, Yoshimura A
- Journal Title
  
  J Exp Med 203(6)
  
  Pages: 1391-1397
- Data Source
  KAKENHI-PROJECT-18109005
[Journal Article] Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors.2006
- Author(s)
  Yoshida T, Hisamoto T, Akiba J, Koga H, Nakamura K, Tokunaga Y, Hanada S, Kumemura H, Maeyama M, Harada M, Ogata H, Yano H, Kojiro M, Ueno T, Yoshimura A, Sata M
- Journal Title
  
  Oncogene 25(45)
  
  Pages: 6056-6066
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors.2006
- Author(s)
  Yoshida T, Hisamoto T, Akiba J, Yoshimura A, Sata M, et al.
- Journal Title
  
  Oncogene. 25(45)
  
  Pages: 6056-6066
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1.2005
- Author(s)
  Nonami A, Taketomi T, Kimura A, Yoshimura A, et al.
- Journal Title
  
  Genes Cells. 10(9)
  
  Pages: 887-895
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia.2005
- Author(s)
  Taketomi T, Yoshiga D, Taniguchi K, Yoshimura A, et al.
- Journal Title
  
  Nat Neurosci. 8(7)
  
  Pages: 855-857
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] FLN29, a novel interferon-and LPS-inducible gene acting as a negative regulator of toll-like receptor signaling.2005
- Author(s)
  MashimaR, Saeki K, Aki D, Yoshimura A, et al.
- Journal Title
  
  J Biol Chem. 280(5)
  
  Pages: 41289-97
- Data Source
  KAKENHI-PROJECT-13GS0011
[Journal Article] Induction of hyper Th1 cell-type immune responses by dendritic cells lacking the suppressor of cytokine signaling-1 gene.2005
- Author(s)
  Hanada T, Tanaka K, Yoshimura A, et al.
- Journal Title
  
  J Immunol. 174(7)
  
  Pages: 4325-4332
- Data Source
  KAKENHI-PROJECT-17014069
[Journal Article] Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness.2005
- Author(s)
  Inoue H, Kato R, Fukuyama S, Nonami A, Yoshimura A, et al.
- Journal Title
  
  J Exp Med. 20(1)
  
  Pages: 73-82
- Data Source
  KAKENHI-PROJECT-13GS0011
[Journal Article] The Sprouty-related protein,Spred-1,localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1.2005
- Author(s)
  Nonami A, Takemoto T, Kimura A, Yoshimura A, et al.
- Journal Title
  
  Genes Cells. 10(9)
  
  Pages: 887-95
- Data Source
  KAKENHI-PROJECT-13GS0011
[Journal Article] Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness.2005
- Author(s)
  Inoue H, Kato R, Fukuyama S, Nonami A, Yoshimura A
- Journal Title
  
  J Exp Med. 201
  
  Pages: 73-82
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12219216
[Journal Article] Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness.2005
- Author(s)
  Inone H, Kato R, Fukuyama S, Nonami A, Yoshimura A.
- Journal Title
  
  J Exp Med. 201
  
  Pages: 73-82
- Data Source
  KAKENHI-PROJECT-12219216
[Journal Article] Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia.2005
- Author(s)
  Taketomi T, Yoshiga D, Taniguchi K, Yoshimura A, et al.
- Journal Title
  
  Net Neurosci. 8(7)
  
  Pages: 855-7
- Data Source
  KAKENHI-PROJECT-13GS0011
[Journal Article] Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness.2005
- Author(s)
  Inoue H, Kato R, Fukuyama S, Nonami A, Yoshimura A
- Journal Title
  
  J Exp Med. 201
  
  Pages: 73-82
- Data Source
  KAKENHI-PROJECT-13GS0011
[Journal Article] Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness.2005
- Author(s)
  Inoue H, Kato R, Fukuyama S, Nonami A, Taniguchi K, Matsumoto K, Nakano T, Tsuda M, Matsumura M, Kubo M, lshikawa F, Moon BG, Takatsu K, Nakanishi Y, Yoshimura A.
- Journal Title
  
  J Exp Med. 201
  
  Pages: 73-82
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12219216
[Journal Article] Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells.2004
- Author(s)
  Nonami A, Kato R, Taniguchi K, Yoshiga S, Yoshimura A
- Journal Title
  
  J Biol Chem. 279
  
  Pages: 52543-52551
- Data Source
  KAKENHI-PROJECT-13GS0011
[Journal Article] SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis2004
- Author(s)
  Yoshida T, Ogata H, Kamio M, Joo A, Shiraishi H, Yoshimura A
- Journal Title
  
  J Exp Med 199
  
  Pages: 1701-1707
- Data Source
  KAKENHI-PROJECT-13GS0011
[Journal Article] SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis2004
- Author(s)
  Yoshida T, Ogata H, Kamio M, Joo A, Shiraishi H, Yoshimura A
- Journal Title
  
  J Exp Med. 199
  
  Pages: 1701-1707
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12219216
[Journal Article] Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells.2004
- Author(s)
  Nonami A, Kato R, Taniguchi K, Yoshiga D, Yoshimura A.
- Journal Title
  
  J Biol Chem. 279
  
  Pages: 52543-52551
- Data Source
  KAKENHI-PROJECT-12219216
[Journal Article] SOCS3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity2004
- Author(s)
  Mori H, Hanada R, Hanada T, Aki D, Mashima R, Yoshimura A
- Journal Title
  
  Nature Mediciene 10
  
  Pages: 739-743
- Data Source
  KAKENHI-PROJECT-13GS0011
[Journal Article] SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis2004
- Author(s)
  Yoshida T, Ogata H, Kamio M, Joo A, Shiraishi H, Tokunaga Y, Sata M, Nagai, H, Yoshimura, A.
- Journal Title
  
  J Exp Med. 199
  
  Pages: 1701-1707
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12219216
[Journal Article] The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization.2004
- Author(s)
  Miyoshi K, Wakioka T, Nishinakamura H, Kamio M, Yang L, Inoue M, Hasegawa M, Yonemitsu Y, Komiya S, Yoshimura A.
- Journal Title
  
  Oncogene. 23
  
  Pages: 5567-5576
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12219216
[Journal Article] The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization.2004
- Author(s)
  Miyoshi K, Wakioka T, Nishinakamura H, Yoshimura A
- Journal Title
  
  Oncogene. 23
  
  Pages: 5567-5576
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12219216
[Journal Article] STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression.2004
- Author(s)
  Joo A, Aburatani H, Morii E, Iba H, Yoshimura A.
- Journal Title
  
  Oncogene. 23
  
  Pages: 726-734
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12219216
[Journal Article] Hepatitis C Virus Down-Regulates Insulin Receptor Substrates 1 and 2 through Up-Regulation of Suppressor of Cytokine Signaling 3.2004
- Author(s)
  Kawaguchi T, Yoshida T, Harada M, Hisamoto T, Yoshimura A.
- Journal Title
  
  Am J Pathol. 165
  
  Pages: 1499-1508
- Data Source
  KAKENHI-PROJECT-12219216
[Journal Article] SOCS3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity2004
- Author(s)
  Mori H, Hanada R, Hanada T, Aki D, Mashima R, Yoshimura A.
- Journal Title
  
  Nature Mediciene 10
  
  Pages: 739-743
- Data Source
  KAKENHI-PROJECT-12219216
[Journal Article] SOCS1 inhibits HPV-E7-mediated transformation by inducing degradation of E7 protein.2004
- Author(s)
  Kamio M, Yoshida T, Ogata H, Douchi T, Yoshimura A
- Journal Title
  
  Oncogene 17
  
  Pages: 3108-3116
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12219216
[Journal Article] STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression.2004
- Author(s)
  Joo A, Aburatani H, Morii E, Iba H, Yoshimura A
- Journal Title
  
  Oncogene. 23
  
  Pages: 726-734
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12219216
[Journal Article] SOCS1 inhibits HPV-E7-mediated transformation by inducing degradation of E7 protein.2004
- Author(s)
  Kamio M, Yoshida T, Ogata H, Douchi T, Nagata Y, Yoshimura A.
- Journal Title
  
  Oncogene 17
  
  Pages: 3108-3116
- Data Source
  KAKENHI-PROJECT-13GS0011
[Journal Article] Spred-2 Suppresses Aorta-Gonad-Mesonephros Hematopoiesis by Inhibiting MAP Kinase Activation.2004
- Author(s)
  Nobuhisa I, Kato R, Inoue H, Takizawa M, Yoshimura A.
- Journal Title
  
  J Exp Med. 199
  
  Pages: 737-742
- Data Source
  KAKENHI-PROJECT-13GS0011
[Journal Article] The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization.2004
- Author(s)
  Miyoshi K, Wakioka T, Nishinakamura H, Kamio M, Yoshimura A.
- Journal Title
  
  Oncogene. 23
  
  Pages: 5567-5576
- Data Source
  KAKENHI-PROJECT-12219216
[Journal Article] SOCS1 inhibits HPV-E7-mediated transformation by inducing degradation of E7 protein.2004
- Author(s)
  Kamio M, Yoshida T, Ogata H, Douchi T, Nagata Y, Inoue M, Hasegawa M, Yonemitsu Y, Yoshimura A.
- Journal Title
  
  Oncogene. 17
  
  Pages: 3108-3116
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12219216
[Journal Article] IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages2003
- Author(s)
  Yasukawa H, Ohishi M, Mori H, Murakami M, Chinen T, Aki D, Hanada T, Takeda K, Akira S, Hoshijima M, Hirano T, Chien KR, Yoshimura A.
- Journal Title
  
  Nature Immunol. 4
  
  Pages: 551-556
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12219216
[Journal Article] IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages.2003
- Author(s)
  Yasukawa H, Ohishi M, Mori H, Murakami M, Yoshimura A
- Journal Title
  
  Nature Immunol. 4
  
  Pages: 551-556
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12219216
[Patent] CD45RA＋およびCCR7＋の細胞表面マーカーを有するT細胞の製造方法2020
- Inventor(s)
  吉村昭彦、近藤泰介、富里亘
- Industrial Property Rights Holder
  吉村昭彦、近藤泰介、富里亘
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20K20384
[Patent] CD45RA＋およびCCR7＋の細胞表面マーカーを有するT細胞の製造方法2020
- Inventor(s)
  吉村昭彦、近藤泰介、富里亘
- Industrial Property Rights Holder
  吉村昭彦、近藤泰介、富里亘
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20K20384
[Patent] CD45RA＋およびCCR7＋の細胞表面マーカーを有するT細胞の製造方法(2020
- Inventor(s)
  吉村昭彦、近藤泰介、富里亘
- Industrial Property Rights Holder
  吉村昭彦、近藤泰介、富里亘
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-17H06175
[Patent] 免疫・炎症性疾患の治療薬2020
- Inventor(s)
  竹内　勤、吉村昭彦、葛西義明
- Industrial Property Rights Holder
  竹内　勤、吉村昭彦、葛西義明
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-17H06175
[Presentation] T 細胞で SOCS3 を欠損したマウスでは IL6 のシグナルの亢進により抗腫瘍作用が増強する2021
- Author(s)
  三瀬　節子、吉村　昭彦
- Organizer
  第 25 回がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-19K07514
[Presentation] Neural Destruction and Repair after Ischemic Brain Injury by Innate and Adaptive Immunity2021
- Author(s)
  Akihiko Yoshimura, Shinichi Yamamoto, Masaki Ohyagi and Minako Ito
- Organizer
  Japan Bone Academy 2021
- Invited
- Data Source
  KAKENHI-PROJECT-21H05044
[Presentation] Neural Destruction and Repair after Ischemic Brain Injury by Innate and Adaptive Immunity2021
- Author(s)
  Akihiko Yoshimura, Shinichi Yamamoto, Masaki Ohyagi and Minako Ito
- Organizer
  2021 Changsha International Symposium on Frontiers in Immunology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H05044
[Presentation] Neural Repair after Ischemic Brain Injury by Innate and Adaptive Immunity2021
- Author(s)
  Akihiko Yoshimura and Minako Ito
- Organizer
  第19回あわじ感染と免疫国際フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-21H05044
[Presentation] 脳内組織損傷後の自然免疫と獲得免疫2021
- Author(s)
  吉村　昭彦、伊藤美菜子
- Organizer
  日本CellDeath学会第29回学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21H05044
[Presentation] Neural Repair of Ischemic Brain Injury by Macrophages and Regulatory T cells2021
- Author(s)
  Akihiko Yoshimura, Shinichi Yamamoto, Masaki Ohyagi and Minako Ito
- Organizer
  Virtual Seminar Series - Institute for Immunology Tsinghua University
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H05044
[Presentation] 腫瘍免疫における T 細胞疲弊のメカニズム2021
- Author(s)
  吉村　昭彦、Tanakorn SRIRAT、安藤眞、三瀬　節子
- Organizer
  第 25 回がん免疫学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07514
[Presentation] Augmentation of IL6 signaling by the deletion of SOCS3 in T cells enhances tumor immunity through the modification of mitochondria states2021
- Author(s)
  Setsuko Mise-Omata, Akihiko Yoshimura
- Organizer
  第 50 回日本免疫学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07514
[Presentation] Neural Repair after Ischemic Brain Injury by Innate and Adaptive Immunity2021
- Author(s)
  Akihiko Yoshimura and Minako Ito
- Organizer
  上原国際シンポジウム2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H05044
[Presentation] Neural Repair of Ischemic Brain Injury by Macrophages and Regulatory T cells2021
- Author(s)
  Akihiko Yoshimura, Shinichi Yamamoto, Masaki Ohyagi and Minako Ito
- Organizer
  The 8th Congress of the FIMSA
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H05044
[Presentation] cAMPを介した免疫制御の分子機構2020
- Author(s)
  吉村昭彦
- Organizer
  第41回日本炎症・再生医学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06175
[Presentation] Molecular mechanism of T cell exhaustion by NR4a nuclear receptors and its reversion2020
- Author(s)
  Akihiko Yoshimura
- Organizer
  第24回日本がん免疫学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06175
[Presentation] Neural Damage and Repair after Ischemic Brain Injury by Innate and Adaptive Immunity2020
- Author(s)
  Akihiko Yoshimura
- Organizer
  The 9th NIF Winter School on Advanced Immunology in Awaji Island
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06175
[Presentation] cAMPを介した免疫制御の分子機構2020
- Author(s)
  吉村昭彦
- Organizer
  第41回日本炎症・再生医学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K20384
[Presentation] Molecular mechanism of T cell exhaustion by NR4a nuclear receptors and its reversion2020
- Author(s)
  Akihiko Yoshimura
- Organizer
  第24回日本がん免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K20384
[Presentation] Regulation of inflammation after ischemic brain injury by innate and adaptive immunity2019
- Author(s)
  Minako Ito, Akihiko Yoshimura
- Organizer
  the 9th international DAMPs and Alarmin Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06175
[Presentation] Neural Repair after ischemic brain injury by Regulatory T cells2019
- Author(s)
  Akihiko Yoshimura, Takashi Schichita and Minako Ito
- Organizer
  NCNP Neuroimmunology international symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06175
[Presentation] Neural Repair after Ischemic Brain Injury by Regulatory T cells2019
- Author(s)
  Minako Ito, Takashi Shichita, Akihiko Yoshimura
- Organizer
  2019, Chinese Society of Immunology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06175
[Presentation] Neural Repair after Ischemic Brain Injury2019
- Author(s)
  Minako Ito, Akihiko Yoshimura
- Organizer
  the 14th World Congress on Inflammation
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06175
[Presentation] 核内受容体NR4aによるT細胞寛容と疲弊2019
- Author(s)
  吉村昭彦
- Organizer
  第11回日本血液疾患免疫療法学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K20384
[Presentation] T cell exhaustion and tolerance by NR4a transcription factors2019
- Author(s)
  Akihiko Yoshimura
- Organizer
  第78回　癌学会講演(シンポジウム1)
- Invited
- Data Source
  KAKENHI-PROJECT-20K20384
[Presentation] メモリーT細胞の性質と抗腫瘍免疫2019
- Author(s)
  吉村昭彦
- Organizer
  第5回日本移植学会スプリングセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-20K20384
[Presentation] 核内受容体NR4aによるT細胞寛容と疲弊のメカニズム2019
- Author(s)
  吉村昭彦
- Organizer
  第一回　PHILOSOPHY
- Invited
- Data Source
  KAKENHI-PROJECT-20K20384
[Presentation] 組織制御性T細胞(Tissue-Treg)による組織損傷の修復2018
- Author(s)
  吉村昭彦
- Organizer
  第３３回　自己免疫疾患研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06175
[Presentation] Metabolic reprogramming requires stem cell moery T cells phenotypes for adaptive immunothrapy2018
- Author(s)
  近藤泰介, 吉村昭彦
- Organizer
  45th Naito Conference "Immunological and Molecular Bases for Cancer Immunotherapy"
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15292
[Presentation] Generation of human induced-stem cell memory T (iTscm) cells for cancer adoptive T cell immunotherapy2018
- Author(s)
  吉村昭彦、近藤泰介
- Organizer
  77回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K20384
[Presentation] Regulation of Inflammation after Stroke by Macrophages and Regulatory T Cells2018
- Author(s)
  吉村昭彦、伊藤美菜子
- Organizer
  Keystone Symposia on New Frontiers in Neuroinflammation,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06175
[Presentation] ミトコンドリア制御によるメモリーT細胞のリプログラミング2018
- Author(s)
  近藤泰介, 吉村昭彦
- Organizer
  第39回日本炎症・再生医学会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20K20384
[Presentation] ミトコンドリア制御によるメモリーT細胞のリプログラミング2018
- Author(s)
  近藤泰介, 吉村昭彦
- Organizer
  第39回日本炎症・再生医学会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16K15292
[Presentation] 脳梗塞後の炎症の収束と組織修復のメカニズム2018
- Author(s)
  吉村昭彦、伊藤美菜子
- Organizer
  第62回サイトカインインターフェロン学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06175
[Presentation] 制御性T細胞のエピジェネティク改変による免疫疾患制御2018
- Author(s)
  吉村昭彦
- Organizer
  第25回　日本免疫毒性学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06175
[Presentation] 疲弊化T細胞を制御するシグナルと転写因子2018
- Author(s)
  吉村昭彦
- Organizer
  第91回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K20384
[Presentation] Generation of human induced-stem cell memory T (iTscm) cells for cancer adoptive T cell immunotherapy2018
- Author(s)
  吉村昭彦
- Organizer
  77回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-16K15292
[Presentation] Metabolic reprogramming requires stem cell moery T cells phenotypes for adaptive immunothrapy2018
- Author(s)
  Taisuke Kondo, Alkihiko Yoshimura
- Organizer
  45th Naito Conference "Immunological and Molecular Bases for Cancer Immunotherapy"
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20384
[Presentation] 制御性T細胞による炎症疾患制御2018
- Author(s)
  吉村昭彦
- Organizer
  第52回日本眼炎症学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06175
[Presentation] Application of Notch-induced Tscm (iTscm) cells for cancer immunotherapy2018
- Author(s)
  Taisuke Kondo, Rimpei Morita, Akihiko Yoshimura
- Organizer
  Keystone symposia: Immunological Memory: Innate, Adaptive and Beyond
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15292
[Presentation] Notch-mediated conversion of activated T cells into stem cell memory T cells facilitates adoptive cancer immunotherapy2017
- Author(s)
  Taisuke Kondo, Rimpei Morita, Akihiko Yoshimira
- Organizer
  5th International Cytokine and Interferon Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15292
[Presentation] Notch シグナルによる活性化 T 細胞からステムセルメモリー T 細胞への転換と免疫療法への応用2017
- Author(s)
  近藤泰介、森田林平、吉村昭彦
- Organizer
  第21回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K15292
[Presentation] Role of Inflammation in the Brain after Stroke2017
- Author(s)
  Akihiko Yoshimura, Minako Ito and Takashi Shichita
- Organizer
  Takeda Science Foundation Symposium on Bioscience No.19
- Place of Presentation
  武田薬品研修所(大阪吹田市)
- Year and Date
  2017-01-20
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221305
[Presentation] Phosphorylation of Akt and Foxos induced by TGF-β negatively regulates the differentiation of induced regulatory T cells.2016
- Author(s)
  Shigenori Nagai, Yutaka Kurebayashi, Yukiko Baba, Akiko Minowa, Miyuki Azuma, Akihiko Yoshimura, Shigeo Koyasu.
- Organizer
  16th International Congress of Immunology
- Place of Presentation
  Melbourne, Australia.
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293400
[Presentation] Notchシグナルによる活性化T細胞のステムセルメモリーT細胞へのリプログラミング2016
- Author(s)
  近藤泰介、吉村昭彦
- Organizer
  第8回シグナルネットワーク研究会
- Place of Presentation
  大阪大学
- Year and Date
  2016-05-27
- Data Source
  KAKENHI-PROJECT-16K15292
[Presentation] NotchシグナルによるステムセルメモリーT細胞の誘導とその応用2016
- Author(s)
  近藤泰介、吉村昭彦
- Organizer
  第31回自己免疫研究会
- Place of Presentation
  東京京王プリンスホテル
- Data Source
  KAKENHI-PROJECT-16K15292
[Presentation] Ｔ細胞の免疫リプログラミング2016
- Author(s)
  吉村昭彦、近藤泰介、染谷和江、岡田匡央、森田林平
- Organizer
  第１５回日本再生医療学会総会
- Place of Presentation
  大阪国際会議場　（大阪府大阪市）
- Year and Date
  2016-03-17
- Invited
- Data Source
  KAKENHI-PROJECT-26670470
[Presentation] A unique interaction between SPRED EVH1 domain and NF1 GRD domain elucidates defective mechanisms of EVH1 missense mutations in Legious syndrome2015
- Author(s)
  Akihiko Yoshimura, Minako Ito, Masahiro Okada, and Takashi Shichita
- Organizer
  Molecular and cellular mechanisms in neurofibromatosis type 1 and related syndromes
- Place of Presentation
  レーベン（ベルギー）
- Year and Date
  2015-05-07
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221305
[Presentation] Computer model analysis of the difference between F759 and wild type mice in rheumatoid-like arthritis emergence2015
- Author(s)
  Satoshi Yamada, Akihiko Yoshimura, Toru Atsumi, Masaaki Murakami
- Organizer
  4th European Congress of Immunology Vienna 2015
- Place of Presentation
  オーストリア　ウィーン
- Year and Date
  2015-09-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25330356
[Presentation] Computer model analysis of the difference between F759 and wild type mice in rheumatoid-like arthritis emergence2015
- Author(s)
  Satoshi Yamada, Akihiko Yoshimura, Toru Atsumi, Masaaki Murakami
- Organizer
  第４４回日本免疫学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-25330356
[Presentation] リウマチ様関節炎発症におけるF759マウスと野生型マウスの違いのコンピュータモデルによる解析2015
- Author(s)
  山田訓、吉村昭彦、熱海徹、村上正晃
- Organizer
  第３８回日本分子生物学会年会第８８回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25330356
[Presentation] Regulation of regulatory T cell fate by NR4a nuclear factors2015
- Author(s)
  Akihiko Yoshimura
- Organizer
  International Symposium on Epigenetics and Autoimmunity
- Place of Presentation
  長沙（中国）
- Year and Date
  2015-04-25
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221305
[Presentation] Smad2 and Smad3 inversely regulate Treg induction by Clostridium butyricum in the intestine2015
- Author(s)
  Akihiko Yoshimura Ikko Kashiwagi
- Organizer
  International Symposium on Immune Regulation
- Place of Presentation
  大洗パークホテル（茨城県東茨城郡）
- Year and Date
  2015-10-29
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221305
[Presentation] Molecular basis for the induction of regulatory T cells by gram-positive bacteria and TGF-beta in the intestine2014
- Author(s)
  Yoshimura A, Okada M, and Kashiwagi, I
- Organizer
  The 24th Hot Spring Harbor International Symposium “Recent Advances in Immunology and Inflammation”
- Place of Presentation
  九州大学（福岡県福岡市）
- Year and Date
  2014-11-07
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221305
[Presentation] Molecular Basis for the Post-Ischemic Inflammation in the Brain2014
- Author(s)
  Akihiko Yoshimura, Minako Ito, Masahiro Okada, and Takashi Shichita
- Organizer
  The 12th International Congress of Neuroimmunology
- Place of Presentation
  マインツ（ドイツ）
- Year and Date
  2014-11-09
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221305
[Presentation] Computer model analysis of the difference between F759 and wild type mice in rheumatoid-like arthritis emergence2014
- Author(s)
  Satoshi Yamada, Akihiko Yoshimura, Toru Atsumi, Masaaki Murakami
- Organizer
  第４３回日本免疫学会学術集会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2014-12-11
- Data Source
  KAKENHI-PROJECT-25330356
[Presentation] リウマチ様関節炎発症におけるF759マウスと野生型マウスの違いのコンピュータモデルによる解析2014
- Author(s)
  山田訓、吉村昭彦、熱海徹、村上正晃
- Organizer
  第３７回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-27
- Data Source
  KAKENHI-PROJECT-25330356
[Presentation] Treg induction by gram-positive bacterium Clostridium Butylicum in the intestine is medaited by TLR2- and Smad3-dependent TGF-be-ta1 production in dendritic cells2014
- Author(s)
  Akihiko Yoshimura, Ikko Kashiwagi
- Organizer
  The Fourth International Conference on Regulatory T Cells and Th Subsets
- Place of Presentation
  上海（中国）
- Year and Date
  2014-11-01
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221305
[Presentation] リウマチのコンピュータモデル2013
- Author(s)
  山田訓、吉村昭彦
- Organizer
  第３６回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25670234
[Presentation] The nuclear orphan receptor Nr4a family isessential for nTreg development and immunehomeostasis2013
- Author(s)
  YOSHIMURA Akihiko and SEKIYA Takashi
- Organizer
  JST-CREST Symposium"Frontiers in Immunology and Inflammation"
- Place of Presentation
  Hitotsubashi Memorial Hall Tokyo
- Data Source
  KAKENHI-PROJECT-22249009
[Presentation] Computer model of rheumatoid arthritis2013
- Author(s)
  Satoshi Yamada, Akihiko Yoshimura
- Organizer
  第４２回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ（千葉市）
- Data Source
  KAKENHI-PROJECT-25670234
[Presentation] Suppression of intestinalinflammation by signals of IL-10, TGF-beta andnovel factors2013
- Author(s)
  Akihiko Yoshimura, Takatoshi Chinen andTakashi Sekiya
- Organizer
  keystone symposium Emerging Topics inImmune System Plasticity: Cellular Networks,Metabolic Control, and Regeneration.
- Place of Presentation
  Santa Fe, New Mexico, USA
- Data Source
  KAKENHI-PROJECT-22249009
[Presentation] 脳虚血後の炎症におけるDAMPs とサイトカインの役割2012
- Author(s)
  吉村昭彦
- Organizer
  第21回内毒素・LPS研究会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23659242
[Presentation] The IL-23-IL-17 axis inthe brain inflammation after stroke2012
- Author(s)
  Akihiko Yoshimura
- Organizer
  The 34th Naito Conference
- Place of Presentation
  Chateraise Gateaux KingdomSAPPORO
- Data Source
  KAKENHI-PROJECT-22249009
[Presentation] Suppression of intestinalinflammation by PGE2, IL-10 and SOCS12012
- Author(s)
  Akihiko Yoshimura
- Organizer
  International Symposium on Immune Toleranceand Mucosal Immunology
- Place of Presentation
  Chengdu, China
- Data Source
  KAKENHI-PROJECT-22249009
[Presentation] Sensitivity analysis of helper T cell differentiation2012
- Author(s)
  Satoshi Yamada, Akihiko Yoshimura
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸
- Year and Date
  2012-12-05
- Data Source
  KAKENHI-PROJECT-23659242
[Presentation] Sensitivity analysis of computer model of helper T cell differentiation2012
- Author(s)
  Satoshi Yamada, Akihiko Yoshimura
- Organizer
  The 3rd Synthetic Immunology Workshop
- Place of Presentation
  京都
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PROJECT-23659242
[Presentation] サイトカインによる免疫制御と脳内炎症2012
- Author(s)
  吉村昭彦
- Organizer
  第40回日本臨床免疫学会総会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23659242
[Presentation] Molecular Bases for the Regulation of DC and T cell responses by TGF-β2012
- Author(s)
  吉村昭彦
- Organizer
  第40会日本免疫学会
- Place of Presentation
  神戸
- Invited
- Data Source
  KAKENHI-PROJECT-22249009
[Presentation] The IL-23-IL-17 axis in the brain inflammation after stroke2012
- Author(s)
  吉村昭彦
- Organizer
  The 34th Naito Conference
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-22249009
[Presentation] Role of TGF-口eta-Smad2/3 signaling in helper Tcell function and differentiation2011
- Author(s)
  Akihiko Yoshimura, Kenji Ichiyama
- Organizer
  20thInternational Rheumatoid symposium
- Place of Presentation
  Kobe
- Year and Date
  2011-07-19
- Data Source
  KAKENHI-PROJECT-22249009
[Presentation] Regulation of innate immune tolerance by PGE2and SOCS1 in the intestine2011
- Author(s)
  Akihiko Yoshimura, Tamiya Taiga, andTakatoshi Chinen
- Organizer
  Joint international meeting of JSICR-MMCB
- Place of Presentation
  Osaka
- Data Source
  KAKENHI-PROJECT-22249009
[Presentation] Important factors in computer model of helper T cell differentiation2011
- Author(s)
  Satoshi Yamada, Akihiko Yoshimura
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-23659242
[Presentation] Role of TGF-beta-Smad2/3 signaling in helper Tcell function and differentiation2011
- Author(s)
  Akihiko Yoshimura, Kenji Ichiyama
- Organizer
  Keystone symposium "TGF-beta" Snowbird
- Place of Presentation
  USA
- Data Source
  KAKENHI-PROJECT-22249009
[Presentation] Role of IL-23 and IL-17-producing gdT cells inthe delayed phase of brain ischemia2010
- Author(s)
  Akihiko Yoshimura, Takashi Shchita, FumieKonoeda
- Organizer
  China Treg/Th17
- Place of Presentation
  Shanghai China
- Data Source
  KAKENHI-PROJECT-22249009
[Presentation] Computer model of helper T cell differentiation with transcription factor's interactions2010
- Author(s)
  Satoshi Yamada, Akihiko Yoshimura
- Organizer
  BMB2010(第33回日本分子生物学会年会、第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸国際展示場
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-20500275
[Presentation] Computer model of helper T cell differentiation2010
- Author(s)
  山田訓, 吉村昭彦
- Organizer
  14th International IL Congress of Immunology
- Place of Presentation
  神戸
- Year and Date
  2010-08-23
- Data Source
  KAKENHI-PROJECT-20500275
[Presentation] SOCS1 is necessary for innate immunetolerance to intestinal flora by regulatingprostaglandin- mediated immunosuppression2010
- Author(s)
  Akihiko Yoshimura
- Organizer
  World Immune Regulation Meeeting -IVDavos
- Place of Presentation
  Switzerland.
- Year and Date
  2010-04-01
- Data Source
  KAKENHI-PROJECT-22249009
[Presentation] Computer model of helper T cell differentiation2010
- Author(s)
  山田訓, 吉村昭彦
- Organizer
  The 2nd Synthetic Immunology Workshop
- Place of Presentation
  京都
- Year and Date
  2010-12-18
- Data Source
  KAKENHI-PROJECT-20500275
[Presentation] SOCS is a molecular link between inflammation and cancer development.2010
- Author(s)
  Akihiko Yoshimura
- Organizer
  International symposium of infection-associated cancers
- Place of Presentation
  Conference Hall of Hokkaido University in Sapporo, Hokkaido, Japan
- Data Source
  KAKENHI-PROJECT-18109005
[Presentation] Computer model of helper T cell differentiation with transcription factor's interactions2010
- Author(s)
  山田訓, 吉村昭彦
- Organizer
  BMB2010
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-20500275
[Presentation] SOCS1 is necessary for innate immune tolerance to intestinal flora by regulating prostaglandin-mediated immunosuppression2010
- Author(s)
  Akihiko Yoshimura
- Organizer
  World Immune Regulation Meeting-IV
- Place of Presentation
  Davos/Switzerland
- Year and Date
  2010-04-01
- Data Source
  KAKENHI-PROJECT-22249009
[Presentation] Role of SOCS1 in innate and adaptive immune tolerance World2010
- Author(s)
  Akihiko Yoshimura
- Organizer
  Immune Regulation Meeting IV
- Place of Presentation
  Davos Switzerland
- Data Source
  KAKENHI-PROJECT-18109005
[Presentation] Computer model of helper T cell differentiation2010
- Author(s)
  Satoshi Yamada, Akihiko Yoshimura
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  神戸国際展示場
- Year and Date
  2010-08-23
- Data Source
  KAKENHI-PROJECT-20500275
[Presentation] Role of SOCS1 in innate and adaptive immune tolerance2010
- Author(s)
  Akihiko Yoshimura
- Organizer
  World Immune Regulation Meeting IV
- Place of Presentation
  Davos Switzerland
- Data Source
  KAKENHI-PROJECT-17014069
[Presentation] T cell differentiation and cytokine network inimmunological diseases2010
- Author(s)
  Akihiko Yo shimura
- Organizer
  第19回国際リウマチシンポジウム
- Place of Presentation
  神戸
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-22249009
[Presentation] SOCS is a molecular link between inflammation and cancer development. International symposium of infection-associated cancers2010
- Author(s)
  Akihiko Yoshimura
- Organizer
  Conference Hall of Hokkaido University in Sapporo
- Place of Presentation
  Hokkaido, Japan
- Data Source
  KAKENHI-PROJECT-17014069
[Presentation] Computer model of helper T cell differentiation2010
- Author(s)
  Satoshi Yamada, Akihiko Yoshimura
- Organizer
  The 2nd Synthetic Immunology Workshop
- Place of Presentation
  京都大学芝蘭会館
- Year and Date
  2010-12-18
- Data Source
  KAKENHI-PROJECT-20500275
[Presentation] Model analysis of Helper T cell differentiation with transcriptional factor's interactions in Th02009
- Author(s)
  Satoshi Yamada, Akihiko Yoshimura
- Organizer
  The 20th International Conference on Genome Informatics
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-20500275
[Presentation] Molecular basis for immune suppression by TGFb/Smad2/3 5th Leukocyte Signal Transduction Workshop2009
- Author(s)
  Akihiko Yoshimura
- Organizer
  sponsored by Aegean Conferences Aldeamar Knossos Royal Village in Hersonissos
- Place of Presentation
  Crete, Greece
- Data Source
  KAKENHI-PROJECT-18109005
[Presentation] 転写因子相互作用を含むヘルパーT細胞分化のモデル化2009
- Author(s)
  山田訓, 吉村昭彦
- Organizer
  第39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-20500275
[Presentation] 転写因子相互作用を含むヘルパーT細胞分化のモデル化2009
- Author(s)
  山田訓,吉村昭彦
- Organizer
  第39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-20500275
[Presentation] sponsored by Aegean ConferencesAldeamar Knossos Royal Village in Hersonissos2009
- Author(s)
  Akihiko Yoshimura
- Organizer
  Molecular basis for immune suppression by TGFb/Smad2/3 5th Leukocyte Signal Transduction Workshop
- Place of Presentation
  Crete, Greece
- Data Source
  KAKENHI-PROJECT-17014069
[Presentation] Model analysis of Helper T cell differentiation with transcriptional factor's interactions in Th02009
- Author(s)
  山田訓, 吉村昭彦
- Organizer
  The 20th International Conference on Genome Informatics
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20500275
[Presentation] ヘルパーT細胞分化のモデル化2008
- Author(s)
  山田訓,吉村昭彦
- Organizer
  第31回日本分子生物学会年会第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-20500275
[Presentation] ヘルパーT細胞分化のモデル化2008
- Author(s)
  山田訓,吉村昭彦
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-20500275
[Presentation] ヘルパーT細胞分化のモデル化2008
- Author(s)
  山田訓, 吉村昭彦
- Organizer
  第31回日本分子生物学会年会第81回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-20500275
[Presentation] ヘルパーT細胞分化のモデル化2008
- Author(s)
  山田訓, 吉村昭彦
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-20500275
[Presentation] SOCS1 and SOCS3 are Critical Regulators of Cytokine Signaling2007
- Author(s)
  Akihiko Yoshimura
- Organizer
  Implication for Helper T Cell Differentiation and Tumor Development.
- Place of Presentation
  KEYSTONE SYMPOSIA on Molecular and Cellular BiologyKeystone USA
- Data Source
  KAKENHI-PROJECT-18109005
[Presentation] SOCS1 and SOCS3 are Critical Regulators of Cytokine Signaling ; Implication for Helper T Cell Differentiation and Tumor Development2007
- Author(s)
  Akihiko Yoshimura
- Organizer
  KEYSTONE SYMPOSIA on Molecular and Cellular Biology
- Place of Presentation
  Keystone, USA
- Data Source
  KAKENHI-PROJECT-18109005
[Presentation] SOCS1 is a link between inflammation and inflammation-mediated carcinogenesis2007
- Author(s)
  Akihiko Yoshimura
- Organizer
  5th International Aachen Symposium on Cytokine Signalling
- Place of Presentation
  Aachen, Germany
- Data Source
  KAKENHI-PROJECT-18109005
[Presentation] SOCS1 is a link between inflammation and inflammation-mediated carcinogenesis.2007
- Author(s)
  Akihiko Yoshimura
- Organizer
  5th International Aachen Symposium on Cytokine Signalling
- Place of Presentation
  Aachen Germany
- Data Source
  KAKENHI-PROJECT-17014069
[Presentation] SOCS1 and SOCS3 are Critical Regulators of Cytokine Signaling; Implication for Helper T Cell Differentiation and Tumor Development.2007
- Author(s)
  Akihiko Yoshimura
- Organizer
  Implication for Helper T Cell Differentiation and Tumor Development
- Place of Presentation
  KEYSTONE SYMPOSIA on Molecular and Cellular Biology Keystone USA
- Data Source
  KAKENHI-PROJECT-17014069
[Presentation] SOCS1 is a link between inflammation and inflammationmediated carcinogenesis.2007
- Author(s)
  Akihiko Yoshimura
- Organizer
  5th International Aachen Symposium on Cytokine Signalling
- Place of Presentation
  Aachen Germany
- Data Source
  KAKENHI-PROJECT-18109005
[Presentation] Physiological functions of the Sprouty/Spred family proteins,negative regulators for the Ras/ERK pathway2006
- Author(s)
  Akihiko Yoshimura
- Organizer
  BEATSON INTERNATIONAL CANCER CONFERENCE
- Place of Presentation
  Glasgow, UK
- Data Source
  KAKENHI-PROJECT-18109005
[Presentation] Regulation of osteoclastgenesis by inflammatory cytokines and SOCS2006
- Author(s)
  Akihiko Yoshimura
- Organizer
  1st International Conference on Osteoimmunology Ist International meeting of osteoimmunology
- Place of Presentation
  Crete ,Greek
- Data Source
  KAKENHI-PROJECT-18109005
[Presentation] Computer model of rheumatoid arthritis
- Author(s)
  Satoshi Yamada, Akihiko Yoshimura
- Organizer
  第４２回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ（千葉市）
- Data Source
  KAKENHI-PROJECT-25330356
[Presentation] Treg induction by gram-positive bacterium Clostridium Butylicum in the intestine is medaited by TLR2- and Smad3-dependent TGF-be-ta1 production in dendritic cells
- Author(s)
  Yoshimura A, Kashiwagi I, Rottenberg, M.
- Organizer
  The Fourth International Conference on Regulatory T Cells and Th Subsets and Clinical Application in Human Diseases
- Place of Presentation
  Shanghai, China.
- Year and Date
  2014-11-01 – 2014-11-04
- Invited
- Data Source
  KAKENHI-PROJECT-25221305
[Presentation] Treg induction by gram-positive bacterium Clostridium Butylicum in the intestine is medaited by TLR2- and Smad3-dependent TGF-be-ta1 production in dendritic cells
- Author(s)
  Akihiko Yoshimura, Ikko Kashiwagi
- Organizer
  The Fourth International Conference on Regulatory T Cells and Th Subsets and Clinical Application in Human Diseases
- Place of Presentation
  Shanghai, China.
- Year and Date
  2014-11-01 – 2014-11-04
- Invited
- Data Source
  KAKENHI-PROJECT-25670234
[Presentation] 脳梗塞モデルにおける炎症性サイトカインの意義
- Author(s)
  吉村　昭彦
- Organizer
  第46回日本動脈硬化学会総会・学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-10 – 2014-07-11
- Invited
- Data Source
  KAKENHI-PROJECT-25221305
[Presentation] Molecular Basis for the Post-Ischemic Inflammation in the Brain
- Author(s)
  Akihiko Yoshimura, Minako Ito, Masahiro Okada, and Takashi Shichita
- Organizer
  The 12th International Congress of Neuroimmunology
- Place of Presentation
  Mainz, Germany
- Year and Date
  2014-11-09 – 2014-11-13
- Invited
- Data Source
  KAKENHI-PROJECT-25221305
[Presentation] 腸内細菌とTh17による食物アレルギー制御
- Author(s)
  吉村昭彦
- Organizer
  第79回回日本インターフェロン・サイトカイン学会
- Place of Presentation
  北海道大学　札幌市
- Year and Date
  2014-06-19 – 2014-06-20
- Invited
- Data Source
  KAKENHI-PROJECT-25221305
[Presentation] 腸内細菌による食物アレルギーおよび Treg の制御
- Author(s)
  吉村昭彦
- Organizer
  第35回日本炎症・再生医学会総会
- Place of Presentation
  沖縄・万国津梁館
- Year and Date
  2014-07-01 – 2014-07-04
- Invited
- Data Source
  KAKENHI-PROJECT-25670234
[Presentation] リウマチのコンピュータモデル
- Author(s)
  山田訓、吉村昭彦
- Organizer
  第３６回日本分子生物学会年会
- Place of Presentation
  神戸国際展示場（神戸市）
- Data Source
  KAKENHI-PROJECT-25330356
[Presentation] TGF-βによるAktおよびFoxoのリン酸化はiTreg分化を負に制御する
- Author(s)
  永井重徳，紅林泰，東みゆき，吉村昭彦，小安重夫．
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26293400
[Presentation] 制御性T細胞の分化誘導を調節する生薬エキスのスクリーニング
- Author(s)
  小谷仁司　中川竜介　吉村昭彦　渡辺恵史
- Organizer
  日本生薬学会第61回年会
- Place of Presentation
  福岡大学薬学部
- Year and Date
  2014-09-13 – 2014-09-14
- Data Source
  KAKENHI-PROJECT-25460132
[Presentation] Molecular Basis for the Post-Ischemic Inflammation in the Brain
- Author(s)
  Akihiko Yoshimura, Minako Ito, Masahiro Okada, and Takashi Shichita
- Organizer
  The 12th International Congress of Neuroimmunology
- Place of Presentation
  Mainz, Germany
- Year and Date
  2014-11-09 – 2014-11-13
- Invited
- Data Source
  KAKENHI-PROJECT-25670234
[Presentation] Phosphorylation of Akt and Foxos induced by TGF-β negatively controls the differentiation of Induced Regulatory T Cells.
- Author(s)
  Shigenori Nagai, Yutaka Kurebayashi, Miyuki Azuma, Akihiro Yoshimura, Shigeo Koyasu
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26293400
[Presentation] Molecular basis for the induction of regulatory T cells by gram-positive bacteria and TGF-beta in the intestine
- Author(s)
  Yoshimura A, and Kashiwagi I
- Organizer
  Recent Advances in Immunology and Inflammation
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2014-11-07 – 2014-11-08
- Invited
- Data Source
  KAKENHI-PROJECT-25221305
[Presentation] Molecular basis for the induction of regulatory T cells by gram-positive bacteria and TGF-beta in the intestine
- Author(s)
  Yoshimura A, Okada M, and Kashiwagi
- Organizer
  Recent Advances in Immunology and Inflammation
- Place of Presentation
  Fukuoka
- Year and Date
  2014-11-07 – 2014-11-08
- Invited
- Data Source
  KAKENHI-PROJECT-25670234

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Yoshimura Akihiko 吉村 昭彦

YOSHIMURA Akihiko 吉村 昭彦

吉村 昭彦

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Elucidation of the molecular mechanism of memory T cell exhaustion and development of its reprogramming methodPrincipal Investigator

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Brain inflammation and repair mechanism by adaptive immunityPrincipal Investigator

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Development of T cell reprogramming method by metabolic and epigenomic modificationPrincipal Investigator

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Immune systems involved in the resolution of inflammation and tissue repairPrincipal Investigator

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Generation and Application of Stem Cell Memory T CellsPrincipal Investigator

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Identification of Cellular Signaling Mechanism that regulates inflammation and tissue repairingPrincipal Investigator

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Systemic Biology of T cell differentiationPrincipal Investigator

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Yoshimura Akihiko 吉村昭彦

YOSHIMURA Akihiko 吉村昭彦

吉村昭彦