HARADA Mine 原田実根

… Alternative Names

Researcher Number	00019621
Other IDs
Affiliation (based on the past Project Information) *help	2007: Kyushu University, Faculty of Medicine, Visiting researcher 2007: Kyushu University, 大学院・医学研究院, 教授 2005 – 2006: KYUSHU UNIVERSITY, Graduate School of Medicine, professor, 大学院医学研究院, 教授 2001 – 2005: 九州大学, 大学院・医学研究院, 教授 2004: 九州大学, 大学院・医学研究科, 教授 … More
Review Section/Research Field	Principal Investigator Hematology / Biological Sciences / Hematology / Thoracic surgery Except Principal Investigator 内科学一般 / Hematology / Hematology / Thoracic surgery / Biological Sciences
Keywords	Principal Investigator G-CSF / 同種末梢血幹細胞移植 / 急性GVHD / CFU-GM / 末梢血幹細胞 / NK細胞 / 造血幹細胞 / 末梢血幹細胞移植 / GVHD / エプスタイン・バーウィルス(EBV) … More Except Principal Investigator G-CSF / GM-CSF / G-CSF受容体 / SOCS3 / EBP α / C / Stat3 / ジーンターゲティング / GM-CSF遺伝子発現 / granulopoiesis / ERK / モノクローナル抗体 / cyclin D1 / 大量培養 / CD34 / IL-3 / EBPα / 化学予防 / DNA相同組換え / Rad51関連遺伝子群 / cardiomyocyte / Congental factor XIII deficiency / 心筋細胞増殖 / Gene analysis / GMーCSF遺伝子発現 / 遺伝子多型 / Congenital bleeding disorder / インタ-ロイキン4 / インタ-ロイキン6 / 9番染色体長腕欠失 / GーCSF / 酵素免疫測定法 / 幹細胞性白血病 / 顆粒球造血 / 免疫グロブリン遺伝子 / Coagulation factor XIII / 逆相クロマトグラフィー / 発癌 / CSF receptor / mass culture / SCF / 心筋細胞 / エリスロポエンチン / granulopoietin / GMーOSF / 好中球 / 白血病芽球コロニー / 核受容体 / enzyme-linked immunosorbent assay / Gene polymorphism / CSF遺伝子発現 / CD7 / シスプラチン / CSF受容体 / レチノイド / 凝固第XIII因子 / 細胞株 / 相同DNA組み換え機構 / ヌクレオチド除去修復 / リン酸化 / 大量細胞培養 / 先天性凝固第XIII因子欠損症 / cyclin D / レチノイ / 先天性出血性疾患 / グラヌロポエチン / ELISA法 / T細胞受容体遺伝子 / 陰イオン交換クロマトグラフィー / レチノイドレセプター / GーCSF遺伝子発現 / 先天性凝固XIII因子欠損症 / Rad51 / モノクロ-ナル抗体 / Granulopoiesis / monoclonal antibody / 低分子ポリエチレングリコール / G-CSF遺伝子発現 / CMMoL / 幹細胞白血病 / 肺ガン細胞株 / GーCSF受容体 / 9番染色体長腕決失 / サイクリンD1 / 遺伝子解析 / GMーCSF Less

Developmental mechanisms of hematological malignancies revealed by humanized mouse models.Principal Investigator
- Principal Investigator
  
  HARADA Mine
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Kyushu University
Basal reseach of regenerating cardiomyocytes for clinical application -The trial of proliferation of residual cardiomyocytes
- Principal Investigator
  
  SHIOSE Akira, 森田茂樹
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  KYUSHU UNIVERSITY
ヒト造血幹細胞の可塑性を用いた非造血組織疾患の治療と免疫不全ブタを用いた再生型人工組織の作製Principal Investigator
- Principal Investigator
  
  原田実根
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
The mechanism of granulopoiesis and leukemogenesis by the activation of Stat3
- Principal Investigator
  
  SHIMODA Kazuya
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  KYUSHU UNIVERSITY
移植片対腫瘍効果に関する基礎的及び臨床的研究Principal Investigator
- Principal Investigator
  
  原田実根
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
The development of bone marrow injection therapy for chronic myocardial ischemiaPrincipal Investigator
- Principal Investigator
  
  HARADA Mine, 安井久喬
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Kyushu University
核受容体蛋白を標的分子としたがん化学予防の研究
- Principal Investigator
  
  森脇久隆
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
進行肺癌に対する同種末梢血幹細胞移植:移植片対腫瘍効果とCTLの誘導Principal Investigator
- Principal Investigator
  
  原田実根
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Okayama University
NK細胞白血病/リンパ腫の増殖機序と増殖抑制に関する研究Principal Investigator
- Principal Investigator
  
  原田実根
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Kyushu University
  Okayama University
ヒト癌細胞シスプラチン感受性決定因子としてのDNA損傷修復分子機構の解析
- Principal Investigator
  
  高田穣
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
ヒト癌細胞のシスプラチン感受性決定因子としての相同組み換え関連遺伝子群の役割-ノックアウト細胞株と肺癌細胞株による検討-
- Principal Investigator
  
  高田穣
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
高年者白血病に対する同種抹消血幹細胞移植に関する基礎的臨床的研究Principal Investigator
- Principal Investigator
  
  原田実根
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Okayama University
G-CSF-induced mobilization of peripheral blood stem cells trans-plantation and analysis of G-CSF-primed immunocompetent cellsPrincipal Investigator
- Principal Investigator
  
  HARADA Mine
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Hematology
- Research Institution
  OKAYAMA UNIVERSITY
肺小細胞癌の生物学的特性を利用する末梢血幹細胞移植に関する基礎的臨床的研究Principal Investigator
- Principal Investigator
  
  原田実根
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Okayama University
Basic and clinical research of allogeneic peripheral blood stem cell transplantationPrincipal Investigator
- Principal Investigator
  
  HARADA Mine
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Okayama University Medical School
Clinical application of polymorphisms in coagulation factor XIII A subunit gene and molecular analysis of the patients with its deficiency.
- Principal Investigator
  
  OKAMURA Takashi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  KYUSHU UNIVERSITY
幹細胞性白血病の分子生物学的特性に関する研究Principal Investigator
- Principal Investigator
  
  原田実根, SHIBUYA Tsunefumi
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Kyushu University
白血病細胞増殖におよぼす組み換え造血因子と造血微細環境の作用
- Principal Investigator
  
  NIHO Yoshiyuki
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyushu University
Studies on granulopoiesis using monoclonal antibodies against granulopoietin
- Principal Investigator
  
  NIHO Yoshiyuki
- Project Period (FY)
  1986 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Hematology
- Research Institution
  Kyushu University

All 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Book

[Book] 日本における造血幹細胞移植の現況と課題,-免疫の進化-シクロスポリン20年の奇跡2006
- Author(s)
  原田実根
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-17390281
[Book] 日本における造血幹細胞移植の現況と課題, -免疫の進化-シクロスポリン20年の奇跡2006
- Author(s)
  原田実根
- Publisher
  医薬ジャーナル社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390281
[Book] Annual Review血液2005(高久史磨、溝口秀昭、坂田洋一、金倉譲、小畠勢二編)2005
- Author(s)
  下田和哉, 原田実根
- Total Pages
  308
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-17390281
[Book] Annual Review血液2005(高久史磨、溝口秀昭、坂田洋一、金倉譲、小畠勢二編)2005
- Author(s)
  下田和哉、原田実根
- Total Pages
  308
- Publisher
  中外医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390281
[Journal Article] Development of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chain^<null> mice.2005
- Author(s)
  Ishikawa F, Harada M
- Journal Title
  
  Blood 106
  
  Pages: 1565-1573
- Data Source
  KAKENHI-PROJECT-17390281
[Journal Article] Efficient engraftment of primary adult T-cell leukemia cells in newborn NOD/SCID/β2-microglobulin^<null> mice.2005
- Author(s)
  Kawano N, Harada M
- Journal Title
  
  Leukemia 19
  
  Pages: 1384-1390
- Data Source
  KAKENHI-PROJECT-17390281
[Journal Article] Mobilization of human lymphoid progenitors after treatment with granulocyte clolony-stimulating factor.2005
- Author(s)
  Imamura R, Harada M
- Journal Title
  
  J Immunol 175
  
  Pages: 2647-2654
- Data Source
  KAKENHI-PROJECT-17390281
[Journal Article] The roles of Stat3 and ERK in G-CSF signaling.2005
- Author(s)
  Kamezaki K, Shimoda K, Numata A, Haro T, Kakumitsu H, Yoshie M, Yamamoto M, Takeda K, Matsuda T, Akira S, Ogawa K, Harada M
- Journal Title
  
  Stem Cells 23
  
  Pages: 252-263
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390302
[Journal Article] Allogeneic stem-cell transplantation with reduced conditioning T-cell leukemia/lymphoma.2005
- Author(s)
  Okamura J, Harada M
- Journal Title
  
  Blood 105
  
  Pages: 4143-4145
- Data Source
  KAKENHI-PROJECT-17390281
[Journal Article] Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/Enhancer-binding protein α in granulocyte colony-stimulating factor signaling pathway.2005
- Author(s)
  Numata A, Harada M
- Journal Title
  
  J Biol Chem 280
  
  Pages: 12621-12629
- Data Source
  KAKENHI-PROJECT-17390281
[Journal Article] Transgenic mice overexpressing murine thrombopoietin develop myelofibrosis and osteosclerosis.2005
- Author(s)
  Kakumitsu H, Harada M
- Journal Title
  
  Leukemia Research 29
  
  Pages: 761-769
- Data Source
  KAKENHI-PROJECT-17390281
[Journal Article] Human Cord Blood- and Bone Marrow-derived CD34^+ Cells Regenerate Gastrointestinal Epithelial Cells.2004
- Author(s)
  Ishikawa F, Yasukawa M, Yoshida S, Nakamura K, Nagatoshi Y, Kanemaru T, Shimoda K, Shimoda S, Miyamoto T, Okamura J, Shultz L.D, Harada M
- Journal Title
  
  FASEB Journal 18
  
  Pages: 1958-1960
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390302
[Journal Article] The role of Tyk2, Stat1 and Stat4 in LPS-induced endotoxin signals.2004
- Author(s)
  Kamezaki K, Shimoda K, Numata A, Matsuda T, Nakayama K, Harada M
- Journal Title
  
  Int Immunol 16
  
  Pages: 1173-1179
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390302
[Journal Article] Tyk2 interacts with and phosphorylates Rack-1, a WD motif containing protein.2004
- Author(s)
  Haro T, Shimoda K, Kakumitsu H, Kamezaki K, Numata A, Ishikawa F, Sekine Y, Muromoto R, Matsuda T, Harada M
- Journal Title
  
  J Immunol 173
  
  Pages: 1151-1157
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390302
[Journal Article] Intracellular signal transduction of interferon on the suppression of haematopoietic progenitor cell growth.2003
- Author(s)
  Kato K, Kamezaki K, Shimoda K, Numata A, Haro T, Aoki K, Ishikawa F, Takase K, Ariyama H, Matsuda T, Miyamoto T, Nagafuji K, Gondo H, Nakayama KI, Harada M
- Journal Title
  
  Br J Haemato 123
  
  Pages: 528-535
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390302
[Journal Article] The lipocalin 24p3, which is an essential molecule in IL-3, withdrawal-induced apoptosis, is not required in the G-CSF withdrawal-induced apoptosis.2003
- Author(s)
  Kamezaki K, Shimoda K, Numata A, Aoki K, Kato K, Takase K, Nakajima H, Ihara K, Haro T, Ishikawa F, Imamura R, Miyamoto T, Nagafuji K, Gondo H, Hara T, Harada M
- Journal Title
  
  Eur J Haematol 71
  
  Pages: 412-417
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390302
[Journal Article] Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by the induction and nuclear translocation of Daxx.2003
- Author(s)
  Aoki K, Shimoda K, Oritani K, Matsuda T, Kamezaki K, Muromoto R, Numata A, Tamiya S, Haro T, Ishikawa F, Takase K, Yamamoto T, Yumioka T, Miyamoto T, Nagafuji K, Gondo H, Nagafuchi S, Nakayama KI, Harada M
- Journal Title
  
  Exp Hematol. 31
  
  Pages: 1317-1322
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390302
[Journal Article] Influence of transplanted dose of CD56+cells on development of graft-versus-host disease in patients receiving G-CSF-mobilized peripheral blood progenitor cells from HLA-identical sibling donors.2003
- Author(s)
  Yamasaki S, Henzan H, Ohno Y, Yamanaka T, Iino T, Itou Y, Kuroiwa M, Maeda M, Kawano N, Kinukawa N, Miyamoto T, Nagafuji K, Shimoda K, Inada S, Hayashi S, Taniguchi S, Shibuya T, Gondo H, Otsuka T, Harada M
- Journal Title
  
  Bone Marrow Transplantaion 32
  
  Pages: 505-510
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390302
[Journal Article] Transgenic Mice Overexpressing Murine Thrombopoietin Develop Myelofibrosis and Osteosclerosis.
- Author(s)
  Kakumitsu H, Kamezaki K, Shimoda K, Karube K, Haro T, Numata A, Shide K, Matsuda T, Oshima K, Harada M
- Journal Title
  
  Leuk Res (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390302
[Journal Article] Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer binding protein a in G-CSF signaling pathway.
- Author(s)
  Numata A, Shimoda K, Kamezaki K,.Haro T, Kakumitsu H, Shide K, Kato K, Miyamoto T, Yamashita Y, Oshima Y, Nakajima H, Iwama A, Aoki K, Takase K, Gondo H, Mano H, Harada M
- Journal Title
  
  JBC (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390302
[Presentation] Studying human leukemic stem cells in mice2007
- Author(s)
  M., Harada, et. al.
- Organizer
  1st Chinese hematological medical doctor association forum
- Place of Presentation
  Beijing, China
- Year and Date
  2007-05-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390281
[Presentation] Studying human leukemic stem cells in mice (Special Lecture).2007
- Author(s)
  Harada M, et. al.
- Organizer
  1^<st>Chinese hematological medical doctor association forum.
- Place of Presentation
  Beijing, China
- Year and Date
  2007-05-19
- Data Source
  KAKENHI-PROJECT-17390281
[Presentation] Studying human leukemic stem cells in mice(Special Lecture)2007
- Author(s)
  Harada M, et. al.
- Organizer
  1st Chinese hematological medical doctor association forum
- Place of Presentation
  Beijing,China
- Year and Date
  2007-05-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390281

1. KIURA Katsuyuki (10243502)

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2. SHINAGAWA Katsuji (00273988)

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3. ISHIMARU Fumihiko (50284097)

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4. NAGAFUJI Kouji (60343323)

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5. TAKENAKA Katsuto (30301295)

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6. SHIMODA Kazuya (90311844)

# of Collaborated Projects: 4 results

# of Collaborated Products: 12 results
7. SHIBUYA Tsunefumi (70133171)

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8. OKAMURA Takashi (30136436)

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9. 高田穣 (30281728)

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10. MIYAMOTO Toshihiro (70343324)

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11. NIHO Yoshiyuki (60091287)

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12. KUDO Jiro (90148940)

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13. OKAMURA Seiichi (20136435)

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14. TESHIMA Takanori (40284096)

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15. MORITA Shigeki (70243938)

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16. NISHIDA Takahiro (50284500)

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17. SHIOSE Akira (30363336)

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18. 権藤久司 (10253428)

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19. 大塚輝久 (20185317)

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22. MURAKAWA Masahiro

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23. OHMOTO Eijiro (50213864)

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24. MASUDA Munetaka (10190365)

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25. SHIMOKAWA Hiroaki (00235681)

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26. EGASHIRA Kensuke (60260379)

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27. MATSUDA Tadashi (20212219)

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28. TOMITA Yukihiro (90180174)

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29. TANOUE Yoshihisa (40372742)

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30. SUMIMOTO Hideki (30179303)

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31. ITO Hiroyuki (70336022)

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32. HARADA Naoki (80404028)

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33. 田端雅弘 (30243504)

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34. 上岡博 (40168612)

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35. 武田俊一 (60188191)

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36. 八木孝司 (80182301)

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37. 瀧川奈義夫 (60325107)

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38. 池田和真 (50176088)

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39. 森脇久隆 (50174470)

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43. 山口研成 (10321845)

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44. 多田慎也 (20135982)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. 木村文昭 (80234376)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
46. 安井久喬 (20089923)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
47. KAMURA Takumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
48. 高松泰

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
49. 大西彰

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
50. 永井卓

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
51. 出口静吾

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
52. 森岡英次

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
53. 大原紀彦

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HARADA Mine 原田 実根

原田 美根 ハラダ ミネ

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Developmental mechanisms of hematological malignancies revealed by humanized mouse models.Principal Investigator

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ヒト造血幹細胞の可塑性を用いた非造血組織疾患の治療と免疫不全ブタを用いた再生型人工組織の作製Principal Investigator

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移植片対腫瘍効果に関する基礎的及び臨床的研究Principal Investigator

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The development of bone marrow injection therapy for chronic myocardial ischemiaPrincipal Investigator

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進行肺癌に対する同種末梢血幹細胞移植:移植片対腫瘍効果とCTLの誘導Principal Investigator

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NK細胞白血病/リンパ腫の増殖機序と増殖抑制に関する研究Principal Investigator

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高年者白血病に対する同種抹消血幹細胞移植に関する基礎的臨床的研究Principal Investigator

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G-CSF-induced mobilization of peripheral blood stem cells trans-plantation and analysis of G-CSF-primed immunocompetent cellsPrincipal Investigator

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肺小細胞癌の生物学的特性を利用する末梢血幹細胞移植に関する基礎的臨床的研究Principal Investigator

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HARADA Mine 原田実根

原田美根ハラダミネ