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SAKAI Noboru  坂井 昇

ORCIDConnect your ORCID iD *help
Researcher Number 10021487
Other IDs
External Links
Affiliation (based on the past Project Information) *help 1997 – 2003: 岐阜大学, 医学部, 教授
1994 – 1995: 岐阜大学, 医学部, 助教授
1988: Department of Neurosurgery, Gifu University School of Medicine, 医学部・脳神経外科学, 助教授
1988: 岐阜大学, 医学部脳神経外科学, 助教授
1986 – 1987: 岐阜大学, 医学部, 助教授
Review Section/Research Field
Principal Investigator
Cerebral neurosurgery
Except Principal Investigator
Cerebral neurosurgery / Cerebral neurosurgery
Keywords
Principal Investigator
brain tumor / Angiogenesis / AgNOR / immunohistochemistry / C6 glioma / endothelial cell / glioblastoma multiforme / β-catenin / caspase / CDDP … More / radiation therapy / MIB / PCNA / gliomas / SCG assay / IORT / glioma / AgNOR in vitro / immunohistochemistry,immunoblotting / Capillary like formation / β-catenin, / angiogenesis / reactive oxygen species / sphingomyelinase / hypoxia / ceramide / Bcl-2 family / apoptosis / phospholipase D / ホスホリパーゼC / 低酸素刺激 / 虚血性脳血管障害 / Bcl-2 / スフィンゴミエリナーゼ / カスパーゼ / ホスホリパーゼD / ネクローシス / アポトーシス / セラミド / 活性酸素 / differentiation / malignancy / TRAP assay / telomerase activity / Telomerase / 乏突起膠腫 / cAMP / 培養細胞 / 増殖能 / 文化誘導 / テロメラーゼ / グリオーマ / 脳腫瘍 / テロメレース / 分化誘導 / テロメレース活性 / 悪性度 / TRAP法 / P53 / MIB-1 / malignant glioma / radiosensitivity / p53 … More
Except Principal Investigator
p53 / グリオーマ / apoptosis / cAMP / ELISA / soluble CD27 / 腫瘍マーカー / Bcl-2 family / アポトーシス / セラミド / subarachnoid hemorrhage / 分化 / 神経幹細胞 / ラット / enzyme-linked immunoabsorbent assay(ESISA) / immunohistochemistory / germinoma / placental alkaline phosphatase (PLAP) / 胎盤アルカリフォスファターゼ / 胎盤アルカリフオスファターゼ(PLAP) / ELISA(enzyme-linked immunoaborbent assay) / 胚腫(germinoma) / ELISA(enzyme-linked immunoabsorbent assay) / 免疫組織化学 / 胎盤アルカリフォスファターゼ(PLAP) / 頭蓋内原発胚腫 / tumor immunotherapy / histidiue-tag chimera protein / human glioblastoma cell line / HLA-24 / peptides of tumor antigen / 分泌型 / ペプチド / β2ミクログロブリン / MHC class Ia / 抗体提示 / 腫瘍免疫療法 / ヒスチジン標識キメラ蛋白 / ヒトグリオーマ細胞 / HLA-A24 / 腫瘍抗原ペプチド / radiation / glima / caspase-3 / ヒト悪性膠腫 / 放射線 / complement C1s / S100 protein / serine protease / glial differentiation / C6 glioma cells / リポフェクション / スタウロスポリン / サイクリックAMP / セリンプロテアーゼ / グリオーマ細胞 / S100タンパク質 / 補体C1s / 分泌型セリンプロテアーゼ / C6グリオーマ細胞 / immunocompetent patient / CSF / tumor marker / soluble interleukin-2 receptor / primary central nervous system lymphoma / solubleCD27 / 頭蓋内悪性リンパ腫 / 免疫不全患者 / 髄液 / ELlSA / soluble IL-2R / 頭蓋内原発悪性リンパ腫 / sphingomyelinase / glioma / ceramide / caspase / anti-cancer drugs / 組織学的分化度(悪性度) / 抗癌剤感受性 / 活性酸素 / スフィンゴミエリナーゼ / カスパーゼ / 抗癌剤 / Bcl-2family / cerebrospinal fluid / vasospasm / glutamine / nitric oxide syntase / choline acetyltransferase / 免疫組織染色 / クモ膜下出血 / 神経支配 / アミノ酸 / 脳血管攣縮 / 脳脊髄液 / 一酸化窒素 / くも膜下出血 / endothelial cell / genetic / polymorphism / endoglin / aneurysm / リモデリング / 平滑筋 / 電子顕微鏡 / 遺伝子多型 / エンドグリン / 内皮細胞 / 脳動脈瘤 / Neural stem cells / Hepatocyte geowth factor / Embryonic stem cell / Neuronal progenitor / Neuronal differentiation / Neural stem cell / Hepatocyte growth factor / PA6 / HGF / ES細胞 / H202 / PC12 / H_2O_2 / serum deprivation / hypoxia / C6cell / PC-12cell / 14-3-3protein / WGAーHRP / 神経可塑性 / Nestin / 一次体性感覚野 / 一次運動野 / 視床 Less
  • Research Projects

    (16 results)
  • Co-Researchers

    (29 People)
  •  肝細胞増殖因子(HGF)による神経幹細胞の増殖・分化誘導の制御

    • Principal Investigator
      岩間 亨, 郭 泰彦
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Gifu University
  •  脳移植を目指した新しい神経幹細胞培養システムの開発

    • Principal Investigator
      岩間 亨
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Gifu University
  •  p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis.

    • Principal Investigator
      IWAMA Toru
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      GIFU UNIVERSITY
  •  The development of immunotherapy for human brain tumor using molecular biothechnology

    • Principal Investigator
      TAKAMI Tsuyoshi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Gifu University
  •  Increased expression and secretion of r-Gsp protein, rat counterpart of complement C1s precursor during differentiation in rat C6 glioma cells

    • Principal Investigator
      SHINODA Jun
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      GIFU UNIVERSITY
  •  β-catenin expression in glioma with reference to autigenesisPrincipal Investigator

    • Principal Investigator
      SAKAI Noboru
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      GIFU UNIVERSITY
  •  実験的視床破壊後の神経回路代償機構に関する検討

    • Principal Investigator
      NISHIMURA Yasuaki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Gifu University
  •  脳虚血時における細胞死シグナル伝達機構の調節に関する検討-シグナル調節蛋白(14-3-蛋白質)の役割

    • Principal Investigator
      NODA Shinji
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Gifu University
  •  Analysis of signal transduction during ceramide-mediated apoptotic pathway in hypoxic PC12 cell deathPrincipal Investigator

    • Principal Investigator
      SAKAI Noboru
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      GIFU UNIVERSITY
  •  SIGNIFICANCE OF BAX/BCL-2 EXPRESSION RATIO DURING APOPTOTIC PATHWAYS OF HUMAN GLIOMA CELLS

    • Principal Investigator
      IWAMA Toru
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      GIFU UNIVERSITY
  •  DIAGNOSTIC UTILITY OF CEREBROSPINAL FLUID(CSF)SOLUBLE CD27(SCD27)FOR PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA USING ENZYME-LINKED IMMUNOSORBENT ASSAY(ELISA)

    • Principal Investigator
      ANDOH Takashi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      ASAHI UNIVERSITY
  •  The genetic approach for intracranial aneurysm.

    • Principal Investigator
      TAKENAKA Katsunobu, 山川 弘保
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      GIFU UNIVERSITY
  •  The study for NOS roles in subarachnoid hemorrhage.

    • Principal Investigator
      KAKU Yasuhiko
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      GIFU UNIVERSITY
  •  Telomerase activity in brain tumors.Principal Investigator

    • Principal Investigator
      SAKAI Noboru
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      GIFU UNIVERSITY
  •  Study on treatment of malignant glioma with reference to IORT using radiosensitaizers.Principal Investigator

    • Principal Investigator
      SAKAI Noboru
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      GIFU UNIVERSITY
  •  Histo pathological and clinical application of placental alkaline phostaphase as a tumor maker for primary intracranial germinoma.

    • Principal Investigator
      HIRATA Toshifumi
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Gifu University
  • 1.  SHINODA Jun (50273131)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 0 results
  • 2.  IWAMA Toru (20303498)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 3.  KAKU Yasuhiko (90242718)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 4.  YOSHIMURA Shin-ichi (40240353)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 5.  TAKENAKA Katsunobu (00283292)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 6.  NAKASHIMA Shigeru (60188935)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  NISHIMURA Yasuaki (60198512)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  NODA Shinji (70303500)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  NAGATA Kouichi (50252143)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  BANNO Yoshiko (50116852)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  YOSHIMI Naoki (30166996)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  HAYAKAWA Daisuke (70252145)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  ANDOH Takashi (90126722)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  YAMADA Mikito (40308672)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  KUBOTA Yoshinori (60278207)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  MORI Hideki (70021433)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  TAKAMI Tsuyoshi (70136943)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  SAIO Masanao (40242721)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  HIRATA Toshifumi (60156669)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  中村 浩幸 (10211434)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  伊藤 和夫 (60093184)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  岡野 幸雄 (10177066)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  矢野 大仁 (00332685)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  森下 竜一 (40291439)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  原 明 (10242728)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  上田 竜也 (60283305)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  山川 弘保 (80291392)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  岩井 知彦 (80223361)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  小林 裕志
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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