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ARAI Heii  新井 平伊

ORCIDConnect your ORCID iD *help
Researcher Number 50167988
Other IDs
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Affiliation (Current) 2020: 順天堂大学, 医学(系)研究科(研究院), 教授
Affiliation (based on the past Project Information) *help 2006 – 2009: 順天堂大学, 医学部, 教授
1997 – 1998: 順天堂大学, 医学部, 教授
1990 – 1996: 順天堂大学, 医学部, 講師
Review Section/Research Field
Principal Investigator
Psychiatric science
Except Principal Investigator
Psychiatric science / Biological Sciences
Keywords
Principal Investigator
アルツハイマー病 / 老年痴呆 / 神経伝達物質 / セロトニン / 神経ペプチド / ヒト脳 / アルツハイマ-病 / Alzheimer's disease / Senile Dementia / Neurotransmitter … More / Serotonin / Neuropeptide / Human Brain / 記憶 / 一酸化窒素 / アルツハイマー型痴呆 / memory / nitric oxide / Alzheimer-type dementia … More
Except Principal Investigator
アルツハイマー病 / 多因子疾患 / ゲノム / Dynamin2 / アミロイドβ蛋白 / APPトランスジェニックマウス / リスク遺伝子 / SORL1 / KIBRA / 罹患同胞対 / ダイナミン / 第21染色体 / 第12染色体短腕 / アポリポ蛋白E / 第八因子 / SURB遺伝子 / アポリポ蛋白C1 / アポリポ蛋白C2 / 神経成長因子(NGF) / 脳移植 / AChE陽性ニュ-ロン / 体重増加の抑制 / 摂食量 / NGF定量 / 雌雄差 / AchE陽性ニュ-ロン / 体重変化 / AchE組織化学 / Nerve growth factor (NGF) / Brain transplantation / AChE-positive cells / Body weight gain / food intake / NGF concentration / male-female defference / カルシウム結合蛋白 / カルビンディン / トランスジェニック マウス / アルツハイマー型痴呆 / in situハイブリダイゼーション / 免疫組織化学法 / パルブアルブミン / アンチセンスRNA / トランスジェニックマウス / in situ ハイブリダイゼーション / アンチセンス遺伝子導入 / メッセンジャーRNA / calcium binding protein / calbindin / transgenic mice / antisense RNA / in situ hybridization / immunohistochemistry / Alzheimer-type dementia / parvalbumin Less
  • Research Projects

    (5 results)
  • Research Products

    (16 results)
  • Co-Researchers

    (29 People)
  •  Genetic study on Alzheimer Disease

    • Principal Investigator
      TAKEDA Masatoshi
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  A study of transgenic mice with reduced calbindin-D28K expression

    • Principal Investigator
      TAKAHASHI Tadashi
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Juntendo University
  •  Studies on the role of nitric oxide in memory functionPrincipal Investigator

    • Principal Investigator
      ARAI Heii
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Juntendo University
  •  Neurochemical and Pharmacological Studies on the Disturbances in Serotonergic systems in Alzheimer-type DementiaPrincipal Investigator

    • Principal Investigator
      ARAI Heii
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Psychiatric science
    • Research Institution
      Juntendo University School of Medicine
  •  A study of degenerative and regenerative changes in neuronal circuitry in the brain of senile dementia of Alzheimer type : influence of nerve growth factor on adult rat brain

    • Principal Investigator
      IIZUKA Reiji
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Juntendo University School of Medicine

All 2009 2008 2007 2005

All Journal Article

  • [Journal Article] Genetic association analysis between TDP-43 polymorphisms and Alzheimer's disease in a Japanese population.2009

    • Author(s)
      Shibata N, Ohnuma T, Baba H, Arai H.
    • Journal Title

      Dement Geriatr Cogn Disord. 28(4)

      Pages: 325-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019043
  • [Journal Article] Genetic association analysis between TDP-43 polymorphisms and Alzheimer's disease in a Japanese population2009

    • Author(s)
      Shibata N, Ohnuma T, Baba H, Arai H.
    • Journal Title

      Dement Geriatr Cogn Disord. 28

      Pages: 325-329

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019043
  • [Journal Article] The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system.2009

    • Author(s)
      Yanagida K, Okochi M, Tagami S, Nakayama T, Kodama TS, Nishitomi K, Jiang J, Mori K, Tatsumi S, Arai T, et al
    • Journal Title

      EMBO Mol Med. Jul;1(4):

      Pages: 223-235

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019043
  • [Journal Article] No genetic association between polymorphisms of heme oxygenase 1 and 2 and Alz heimer's disease in a Japanese population.2009

    • Author(s)
      Shibata N, Ohnuma T, Baba H, Arai H.
    • Journal Title

      Dement Geriatr Cogn Disord. 27(3)

      Pages: 273-277

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019043
  • [Journal Article] ssociation between polymorphisms of heme oxygenase 1 and 2 and Alz heimer's disease in a Japanese population.2009

    • Author(s)
      Shibata N, Ohnuma T, Baba H, Arai H.
    • Journal Title

      Dement Geriatr Cogn Disord. 27(3)

      Pages: 273-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019043
  • [Journal Article] Sugar chains of cerebrospinal fluid transferrin as a new biological marker of Alzheimer's disease2008

    • Author(s)
      Taniguchi M, Okayama Y, Hashimoto Y, Kitaura M, Jimbo D, Wakutani Y, Wada-Isoe K, Nakashima K, Akatsu H, Furukawa K. Arai H. Urakami K.
    • Journal Title

      Dement Geriatr Cogn Disord 26(2)

      Pages: 117-22

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019043
  • [Journal Article] Sugar chains of cerebrospinal fluid transferrin as a new biological marker of Alzheimer's disease.2008

    • Author(s)
      Taniguchi, M., Okayama, Y., Hashimoto, Y., Kitaura, M., Jimbo, D., Wakutani, Y., Wada-Isoe, K., Nakashima, K., Akatsu, H., Furukawa, K., Arai, H., Urakami, K. Dement
    • Journal Title

      Geriatr Cogn Disord. 26(2)

      Pages: 117-22

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019043
  • [Journal Article] Genetic association between SORL1 polymorphisms and Alzheimer's disease in a Japanese population.2008

    • Author(s)
      Shibata N, Ohnuma T, Baba H, Higashi S, Nishioka K, Arai H.
    • Journal Title

      Dement Geriatr Cogn Disord 26(2)

      Pages: 161-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019043
  • [Journal Article] Genetic association between SORL1 polymorphisms and Alzheimer's disease in a Japanese population2008

    • Author(s)
      Shibata N, Ohnuma T, Baba H, Higashi S, Nishioka K, Arai H.
    • Journal Title

      Dement Geriatr Cogn Disord 26(2)

      Pages: 161-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019043
  • [Journal Article] Genetic association between Notch4 polymorphisms and Alzhe imer's disease in the Japanese population.2007

    • Author(s)
      Shibata, N・Ohnuma, T・Higashi, S・Higashi, M・Usui, C・Ohkubo, T・Watanabe, T・Kawashima, R・Kitajima, A・Ueki, A・Nagao, M・Arai, H.
    • Journal Title

      J Gerontol A Biol Sci -Med Sci 62

      Pages: 350-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019043
  • [Journal Article] Brain-derived neurotrophic factor gene polymorphisms and Alzheimer's disease.2005

    • Author(s)
      Matsushita S, Arai H, Matsui T, Yuzuriha T, Urakami K, Masaki T, Higuchi S.
    • Journal Title

      J Neural Transm. 112(5)

      Pages: 703-11

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019043
  • [Journal Article] Genetic association between matrix metalloproteinase MMP-9 and MMP-3 polymorphisms and Japanese sporadic Alzheimer's disease.2005

    • Author(s)
      Shibata N, Ohnuma T, Higashi S, Usui C, Ohkubo T, Kitajima A, Ueki A, Nagao M, Arai H.
    • Journal Title

      Neurobiol Aging. 26(7)

      Pages: 1011-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019043
  • [Journal Article] Risk of falls in Alzheimer's disease: a prospective study.2005

    • Author(s)
      Horikawa E, Matsui T, Arai H, Seki T, Iwasaki K, Sasaki H.
    • Journal Title

      Intern Med. 44(7)

      Pages: 717-21

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019043
  • [Journal Article] Clinical diagnosis of MM2-type sporadic Creutzfeldt-Jakob disease.2005

    • Author(s)
      Hamaguchi T,Kitamoto T, Sato T, Mizusawa H, Nakamura Y,Noguchi M, Furukawa Y, Ishida C, Kuji I,Mitani K, Murayama S, Kohriyama T, KatayamaS, Yamashita M, Yamamoto T, Udaka F, KawakamiA, Ihara Y, Nishinaka T, Kuroda S, Suzuki N,Shiga Y, Arai H, Maruyama M, Yamada M.
    • Journal Title

      Neurology. 64(4)

      Pages: 643-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019043
  • [Journal Article] Brain-derived neurotrophic factor gene polymorphisms and Alzheimer's disease.2005

    • Author(s)
      Matsushita S, Arai H, Matsui T, Yuzuriha T, Urakami K, Masaki T, Higuchi S.
    • Journal Title

      Journal of Neural Transmission 112

      Pages: 703-711

    • Data Source
      KAKENHI-PROJECT-17019043
  • [Journal Article] Genetic association between matrix metalloproteinase MMP-9 and MMP-3 polymorphisms and Japanese sporadic Alzheimer's disease.2005

    • Author(s)
      Shibata N, Ohnuma T, Higashi S, Usui C, Ohkubo T, Kitajima A, Ueki A, Nagao M, Arai H.
    • Journal Title

      Neurobiology of Aging 26・7

      Pages: 1011-1014

    • Data Source
      KAKENHI-PROJECT-17019043
  • 1.  IWAMOTO Norihiko (60211067)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 2.  KAMINO Koujin (40307955)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  KIMURA Michihiro (50234381)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  TAKAHASHI Tadashi (30236294)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  TAKEDA Masatoshi (00179649)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  MORIHARA Takeshi (90403196)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  TANAKA Toshihisa (10294068)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  AKATSU Hiroyasu (00399734)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 9.  MAEDA Kiyoshi (80116251)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  NAKAJIMA Kenji (70144673)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 11.  YAMAGATA Hidehisa (00304618)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  TAGUCHI Keiko (20457378)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  SHIBATA Nobuto (50365615)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 14.  YAMAMOTO Yasusji (00324921)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 15.  WADA kenji (60346351)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 16.  IIZUKA Reiji (00052952)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  NOGUCHI Iwahide (30237820)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  MINAMI Masayuki (50229770)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  ICHIMIYA Yosuke (10184631)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  OHNUMA Tohru (10286734)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  NISHIYAMA Etsuko (70286748)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  河村 哲 (20204779)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  井上 令一 (10053000)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  桐野 衛二 (90276460)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  KIMURA Ryo
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  HAYASHI Noriyuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  YOKOKOJI Mikiko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  BABA Hajime
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  ETO Kou
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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