YANAGISAWA Katsuhiko 柳澤勝彦

Researcher Number	10230260
Other IDs
Affiliation (based on the past Project Information) *help	2011 – 2012: 独立行政法人国立長寿医療研究センター, 研究所, 副所長 2009 – 2010: National Institute for Longevity Sciences,NCGG, 副所長 2006 – 2009: National Institute for Longevity Sciences,NCGG, 副所長 2004 – 2005: Natl Inst for Longevity Sci., Dept of Alzheimer's Disease Research, Head, (研究所), 副所長 2003: 国立長寿医療センター, (研究所)・アルツハイマー病研究部, 部長 … More 2001 – 2003: 国立長寿医療研究センター, 痴呆疾患研究部, 部長 2002: 国立療養所中部病院, 長寿医療研究センター・痴呆疾患研究部, 部長 2001: 国立療養所中部病院(長寿医療研究センター), 痴呆疾患研究部, 部長 2000: 国立療養所中部病院, (長寿医療研究センター)・痴呆疾患研究部, 部長 1995 – 1996: 国立中部病院, 長寿医療研究センター・痴呆疾患研究部, 部長 1995: 東京大学, 医学部(医), 助手 1992: TOKYO MEDICAL AND DENTAL UNIVERSITY DEPARTMENT OF NEUROLOGY,INSTRUCTOR, 神経内科, 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Nerve anatomy/Neuropathology / Neurochemistry/Neuropharmacology Except Principal Investigator Nerve anatomy/Neuropathology / Neurochemistry/Neuropharmacology / Neurology
Keywords	Principal Investigator アルツハイマー病 / 老人斑 / アポリポ蛋白E / 遺伝的変異型 / マイクロドメイン / シナプス / ガングリオシド / アミロイド蛋白 / アミロイドβ蛋白 / hereditary variant … More / microdomain / synapse / apolipoprotein F. / ganglioside / amyloid β-protein / Alzheimer's disease / コレステロール / GM1ガングリオシド / 遺伝子変異型 / NMR / 質量分析 / 認知症 / アミロイドベータ蛋白質 / 糖鎖 / 痴呆 / 蛋白質 / 神経変性疾患 / アルツヘイマー病 / アポリポ蛋白 / GM_1ガングリオシド … More Except Principal Investigator アルツハイマー病 / hn cDNA / raft / animal model / ApoE / dementia / amyloid / Alzheimer's disease / 脂質ラフト / 動物モデル / アポE / 痴呆 / アミロイド / senile plaque / amyloidbeta-protein / Alzheimer's Disease / GM1ガングリオシド / preamyloid / diffuse plaque / β-amylodogenesis / 定量 / 髄膜 / アミロイドβ蛋白 / 老人斑 / β蛋白 / XQ28 / X CHROMOSOME / ADRENOLEUKODYSTROPHY / COSMID CLONES / POSITIONAL CLONING / REVERSE GENETICS / HEREDITARY NEURODEGENERATIVE DISEASE / Xg28 / ポジショナルクロ-ニング / リバ-スジェネティックス / ゲノム / クロ-ニング / 遺伝学 / 副腎白質ジストロフィー / X染色体 / Xq28 / 副賢白質ジストロフィー / コスミドクローン / ポジショナルクローニング / リバースジュネティックス / 遺伝性神経疾患 Less

Study on molecular mechanism underlying brain region-specific Ass depositionPrincipal Investigator
- Principal Investigator
  
  YANAGISAWA Katsuhiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  National Center for Geriatrics and Gerontology
Molecular mechanism underlying Ass assembly in Alzheimer brain : pathological and therapeutic significance of an endogenous seed for amyloidPrincipal Investigator
- Principal Investigator
  
  YANAGISAWA Katsuhiko
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute for Longevity Sciences,NCGG
Influence of membrane lipid metabolism on cerebral amyloid deposition and neurodegeneration.
- Principal Investigator
  
  YAMAGUCHI Haruyasu
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Gunma University
An investigation into molecular mechanism underlying Aβ assemblyPrincipal Investigator
- Principal Investigator
  
  YANAGISAWA Katsuhiko
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute for Longevity Sciences
アルツハイマー病脳におけるアミロイドβ蛋白蓄積の初期機構に関する生化学的研究Principal Investigator
- Principal Investigator
  
  柳澤勝彦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  The University of Tokyo
Studies on beta-amyloidogenesis-isolation of membrane-bound Abeta
- Principal Investigator
  
  IHARA Yasuo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  University of Tokyo
POSITIONAL CLONING OF CANDIDATE GENES
- Principal Investigator
  
  MIYATAKE Tadashi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  TOKYO MEDICAL AND DENTAL UNIVERSITY

[Book] Amyloid, arises on the membranes and acts on the membranes. In : Amyloids: Composition, Function and Pathology2012
- Author(s)
  Yanagisawa K.
- Publisher
  edited by Irene P. Halcheck and Nancy R. Vernon: published by Nova Science Publishers, Inc.
- Data Source
  KAKENHI-PROJECT-22300118
[Book] Amyloid, arises on the membranes and acts on the membranes. In:Amyloids: Composition, Function and Pathology (edited by Irene P. Halcheck and Nancy R. Vernon)2012
- Author(s)
  Yanagisawa K.
- Publisher
  Nova Science Publishers, Inc.
- Data Source
  KAKENHI-PROJECT-22300118
[Book] Research Progress in Alzheimer's Disease(edited by Miao-Kun Sun, Pivotal roles of cholesterol and gangliosides in aggregation of amyloid β-protein.)2010
- Author(s)
  Yanagisawa K.
- Publisher
  Nova Science Pulishers, Inc.(in press)
- Data Source
  KAKENHI-PROJECT-17025057
[Book] Comprehensive Glycoscience(edited by Kamerling J.P., Boons G-J., Lee Y.C.,Suzuki A. and Taniguchi N., Glycoconjugates and neurological diseases.)2007
- Author(s)
  Yanagisawa K, Yuki N.
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-17025057
[Book] Comprehensive Glycoscience2007
- Author(s)
  Yuki N & Yanagisawa K.
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-17025057
[Book] Ganglioside and Alzheimer's Disease. In: Sphingolipid Biology2006
- Author(s)
  Yanagisawa K.
- Publisher
  Springer-Verlag, Tokyo
- Data Source
  KAKENHI-PROJECT-17025057
[Book] Sphingolipid Biology.(edited by Hirabayashi Y, Igarashi Y and Merill AH, Ganglioside and Alzheimer's disease.)2006
- Author(s)
  Yanagisawa K.
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-17025057
[Book] Pivotal roles of cholesterol and gangliosides in aggregation of amyloid β-protein. Research Progress in Alzheimer's Disease Interactions.2005
- Author(s)
  Yanagisawa K.
- Publisher
  Nova Science Publisher, Inc, New York(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Book] Cholesterol and Aβ fibrillogenesis. In : Subcellular Biochemistry : Alzheimer's disease-Cellular2005
- Author(s)
  Yanagisawa K.
- Publisher
  Springer-Verlag Heidelberg Germany
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Book] Cholesterol and Aβ cascade : pathological implication of apolipoprotein E in Alzheimer's disease.2005
- Author(s)
  Yanagisawa K.
- Publisher
  The Patherson Publishing Group
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Book] Cholesterol and amyloid β fibrillogenesisIn: Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid β(edited by Robin Harris and Falk Fahrenholz)2005
- Author(s)
  Yanagisawa, K.
- Publisher
  Springer-Verlag
- Data Source
  KAKENHI-PROJECT-17025057
[Book] Cholesterol and Aβ fibrillogenesis.In : Subcellular Biochemistry : Alzheimer' s disease-Cellular2005
- Author(s)
  Yanagisawa K.
- Publisher
  Springer-Verlag(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Book] Cholesterol and amyloid β fibrillogenesis. In : Alzheimer's Disease : Cellular and Molecular Aspects of Amyloid β.2005
- Author(s)
  Yanagisawa K.
- Total Pages
  409
- Publisher
  Springer-Verlag, Heidelberg, Germany
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Book] Cholesterol and Aβ fibrillogenesis. In : SubcelluIar Biochemistry : Alzheimer's disease-Cellular and moleculer aspects of amyloid.2005
- Author(s)
  Yanagisawa K.
- Publisher
  Springer-Vierlag
- Data Source
  KAKENHI-PROJECT-17025057
[Book] Pivotal roles of cholesterol and gangliosides in aggregation of Amyloid β-protein. Research Progress in Alzheimer's Disease Interactions.2005
- Author(s)
  Yanagisawa K.
- Publisher
  Nova Science Publishers, Inc. New York, U.S.A.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Book] Cholesterol and Aβ cascade : pathological implication of apolipoprotein E in Alzheimer's disease.2005
- Author(s)
  Yanagisawa K.
- Publisher
  The Patherson Publishing Group(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Book] Recent Progress in Alzheimer's and Parkinsons's Diseases(edited by Hanin I,Casabelos R and Fisher A, Cholesterol and Aβ cascade:pathological implication of apolipoprotein E in Alzheimer's disease.)2005
- Author(s)
  Yanagisawa K.
- Publisher
  Taylor & Francis
- Data Source
  KAKENHI-PROJECT-17025057
[Book] Cholesterol and amyloid β fibrillogenesis. In : Alzheimer's Disease : Cellular and Molecular Aspects of Amyloid β.2005
- Author(s)
  Yanagisawa K.
- Publisher
  Springer-Verlag Heidelberg Germany
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Book] Possible link between cholesterol and dementia, depression. In : Cognition and Mood.2005
- Author(s)
  Yanagisawa K.
- Publisher
  Nova Science Publishers, Inc. New York, U.S.A
- Data Source
  KAKENHI-PROJECT-17025057
[Book] Possible link between cholesterol and dementia, depression.In : Cognition and Mood2005
- Author(s)
  Yanagisawa K.
- Publisher
  Nova Science Publishers, Inc. New York, U.S.A(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Book] Cholesterol and amyloid β fibrillogenesis. In : Alzheimer's Disease : Cellular and Molecular Aspects of Amyloid β.2005
- Author(s)
  Yanagisawa K.
- Total Pages
  409
- Publisher
  Springer-Verlag, Heidelberg, Germany
- Data Source
  KAKENHI-PROJECT-17025057
[Book] Possible link between cholesterol and dementia, depression.In : Cognition and Mood2005
- Author(s)
  Yanagisawa K.
- Publisher
  Nova Science Publishers, Inc. New York, U.S.A.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Book] Cholesterol and Aβ cascade : pathological implication of apolipoprotein E in Alzheimer's and Parkinson's disease.2005
- Author(s)
  Yanagisawa K.
- Publisher
  The Patherson Publishing Group
- Data Source
  KAKENHI-PROJECT-17025057
[Book] Amyloidogenesis and cholesterol. In : Mapping the Progress of Alzheimer's disease and Parkinson's disease.2002
- Author(s)
  Yanagisawa K. et al.
- Publisher
  Kluwer Academic/Plenum Publishers
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Book] Amyloidogenesis and cholesterol. In : Mapping the Progress of Alzheimer's disease and Parkinson's disease.2002
- Author(s)
  Yanagisawa K.他
- Total Pages
  565
- Publisher
  Kluwer Academic/Plenum Publishers
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Density of GM1 in Nanoclusters Is a Critical Factor in the Formation of a Spherical Assembly of Amyloid β-Protein on Synaptic Plasma Membranes.2013
- Author(s)
  Teruhiko Matsubara, Kazutoshi Iijima, Naoki Yamamoto, Katsuhiko Yanagisawa, and Toshinori Sato
- Journal Title
  
  Langmuir
  
  Volume: 29(7) Issue: 7 Pages: 2258-2264
- DOI
  10.1021/la3038999
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300118, KAKENHI-PROJECT-23241075
[Journal Article] Lysosomal dysfunction in a mouse model of Sandhoff disease leads to accumulation of ganglioside-bound Ass.2012
- Author(s)
  Keilani S., Lun Y., Stevens A.C., Williams H.N., Sjoberg E.R., Khanna R., Valenzaro K.J., Checler F., Buxbaum J.D., Yanagisawa K., Lockhart D.J., Wustman B.A. and Gandy S.
- Journal Title
  
  J Neurosci
  
  Volume: 32 Issue: 15 Pages: 5223-5236
- DOI
  10.1523/jneurosci.4860-11.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300118
[Journal Article] アミロイド蓄積開始機構の解明と治療薬開発への展開2012
- Author(s)
  柳澤勝彦、松崎勝巳、加藤晃一
- Journal Title
  
  最新医学
  
  Volume: 67(第48回ベルツ賞受賞論文) Pages: 138-158
- Data Source
  KAKENHI-PROJECT-22300118
[Journal Article] The γ-secretase inhibitor DAPT increases the levels of gangliosides at neuritic terminals of differentiating PC12 cells.2012
- Author(s)
  Oikawa N., Goto M., Ikeda K., Taguchi R. and Yanagisawa K.
- Journal Title
  
  Neurosci Lett.
  
  Volume: 525 Issue: 1 Pages: 49-53
- DOI
  10.1016/j.neulet.2012.07.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300118, KAKENHI-PROJECT-24619007
[Journal Article] Spectroscopic characterization of intermolecular interaction of amyloid β promoted on GM1 micelles.2011
- Author(s)
  Yagi-Utsumi M. et al. (Yanagisawa K., Kato K.)
- Journal Title
  
  Int J Alzheimers Dis.
  
  Volume: 2011 Issue: 1
- DOI
  10.4061/2011/925073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300118, KAKENHI-PROJECT-22870021
[Journal Article] Pathological significance of ganglioside clusters in Alzheimer's disease.2011
- Author(s)
  Yanagisawa K.
- Journal Title
  
  J Neurochem.
  
  Volume: 116 Issue: 5 Pages: 806-812
- DOI
  10.1111/j.1471-4159.2010.07006.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300118
[Journal Article] Ass behavior on neuronal membranes : aggregation and toxicities2011
- Author(s)
  Yanagisawa K.
- Journal Title
  
  International Journal of Alzheimer's Disease
  
  Volume: (Editorial) Issue: 1
- DOI
  10.4061/2011/286536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300118
[Journal Article] Extracellular and intraneuronal HMW-AbetaOs represent a molecular basis of memory loss in Alzheimer's disease model mouse2011
- Author(s)
  Takamura A, Okamoto Y, Kawarabayashi T, Yokoseki T, Shibata M, Mouri A, Nabeshima T, Sun H, Abe K, Urisu T, Yamamoto N, Shoji M, Yanagisawa K, Michikawa M, Matsubara E
- Journal Title
  
  Mol Neurodegener
  
  Volume: 6 Issue: 1 Pages: 20-20
- DOI
  10.1186/1750-1326-6-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591069, KAKENHI-PROJECT-22300118, KAKENHI-PROJECT-23659449, KAKENHI-PROJECT-23659450
[Journal Article] Gender effect on the accumulation of hyperphosphorylated tau in the brains of locus-ceruleus-injured APP transgenic mouse2010
- Author(s)
  Oikawa N, Ogino K, Masumoto T, Yamaguchi H, Yanagisawa K.
- Journal Title
  
  Neurosci. Lett. 468
  
  Pages: 243-247
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Ass polymerization through interaction with membrane gangliosides.2010
- Author(s)
  Matsuzaki K, (Yanagisawa K), et al.
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1801 Pages: 868-877
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300118
[Journal Article] Surface-induced phase separation of a sphingomyelin/cholesterol/ganglioside GM1-planar bilayer on mica surfaces and microdomain molecular conformation that accelerates Ass oligomerization.2010
- Author(s)
  Mao Y, (Yamamoto N, Yanagisawa K), et al.
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1798 Pages: 1090-1099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300118
[Journal Article] Alzheimer-type tau pathology in advanced nonhuman primate brains harboring substantial amyloid depositio2010
- Author(s)
  Oikawa N, Kimura N, Yanagisawa K.
- Journal Title
  
  Brain. Res. 1315
  
  Pages: 137-149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Sphingomyelin accumulation provides a favorable milieu for GM1 ganglioside-induced assembly of amyloid ss-protein.2010
- Author(s)
  Yuyama K, (Yanagisawa K), et al.
- Journal Title
  
  Neurosci Lett
  
  Volume: 481 Pages: 168-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300118
[Journal Article] Alzheimer-type tau pathology in advanced aged nonhuman primate brainsharboring substantial amyloid deposition.2010
- Author(s)
  Oikawa N, (Yanagisawa K), et al.
- Journal Title
  
  Brain research 1315
  
  Pages: 137-149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Surface-induced phase separation of a sphingomyelin / cholesterol / ganglioside GM1-planar bilayer on mica surfaces and microdomain molecular conformation that accelerates As oligomerization2010
- Author(s)
  Mao Y, Zhiguo S, Imai Y, Hoshino T, Tero R, Tanaka M, Yamamoto N, Yanagisawa K, Urisu T.
- Journal Title
  
  Biochim Biophys Acta (in press)
  
  Pages: 22-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] A polymerization through interaction with membrane gangliosides2010
- Author(s)
  Matsuzaki K(Yanagisawa K), et al.
- Journal Title
  
  Biochim Biophys Acta (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Gender effect on the accumulation of hyperphosphorylated tau in the brain of locus-ceruleus-injured APP-transgenic mouse.2010
- Author(s)
  Oikawa N, (Yanagisawa K), et al.
- Journal Title
  
  Neuroscience letters 468
  
  Pages: 243-247
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Surface-induced phase sepaiation of a sphingomyelin/cholesterol/ganglioside GM1-planar bilayer on mica surfaces and microdomain molecular conformation that accelerates Ass oligomerization.2010
- Author(s)
  Mao Y(Yanagisawa K), et al.
- Journal Title
  
  Biochim Biophys Acta (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Pathological significance of ganglioside clusters in Alzheimer's disease.2010
- Author(s)
  Yanagisawa K.
- Journal Title
  
  J Neurochem
  
  Volume: 116 Pages: 806-812
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300118
[Journal Article] Ass polymerization through interaction with membrane gangliosides.2010
- Author(s)
  Matsuzaki K, Kato K, Yanagisawa K
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1801(8) Issue: 8 Pages: 868-877
- DOI
  10.1016/j.bbalip.2010.01.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300118
[Journal Article] Up-and-down topological mode of amyloid β-peptide lying on hydrophilic/hydrophobic interface of ganglioside clusters.2009
- Author(s)
  Utsumi M, (Yanagisawa K), et al.
- Journal Title
  
  Glycoconjugate J (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Late endocytic dysfunction as a putative cause of amyloid fibril formation in Alzheimer's disease.2009
- Author(s)
  Yuyama K, Yanagisawa K.
- Journal Title
  
  J Neurochem (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Gangliosides determine the amyloid pathology of Alzheimer's disease.2009
- Author(s)
  Oikawa N, (Yanagisawa K), et al.
- Journal Title
  
  Neuroreport 20
  
  Pages: 1043-1046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Depletion of vitamin E increases amyloid beta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease.2009
- Author(s)
  Nishida Y, (Yanagisawa K), et al.
- Journal Title
  
  The Journal of biological chemistry 284
  
  Pages: 33400-33408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Bioactive TGF-beta can associate with lipoproteins and is enriched in those containing apolipoprotein E3.2009
- Author(s)
  Tesseur I, (Yanagisawa K), et al.
- Journal Title
  
  Journai of neurochemistry 110
  
  Pages: 1254-1262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] ate endocytic dysfunction as a putative cause of amyloid fibril formation in Alzheimer's disease2009
- Author(s)
  Yuyama., Yanagisawa K.
- Journal Title
  
  J. Neurochem 109
  
  Pages: 1250-1260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Gangliosides determine the amyloid pathology of Alzheimer disease.2009
- Author(s)
  Oikawa N, (Yanagisawa K), et al.
- Journal Title
  
  Neuroreport (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Late endocytic dysfunction as a putative cause of amyloid fibril formation in Alzheimer's disease.2009
- Author(s)
  Yuyama K, (Yanagisawa K)
- Journal Title
  
  Journal of neurochemistry 109
  
  Pages: 1250-1260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Gangliosides determine the amyloid pathology of Alzheimer disease2009
- Author(s)
  Oikawa N, Yamaguchi H, Ogino K, Taki T, Yuyama K, Yamamoto N, Shin R-W., Furukawa K, Yanagisawa K.
- Journal Title
  
  Neuroreport 20
  
  Pages: 143-1046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Up-and-down topological mode of amyloid beta-peptide lying on hydrophilic/hydrophobic interface of ganglioside clusters.2009
- Author(s)
  Utsumi M, (Yanagisawa K), et al.
- Journal Title
  
  Glycoconjugate journal 26
  
  Pages: 999-1006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Up-and-down topological mode of amyloid s-peptide lying on hydrophilic / hydrophobic interface of ganglioside clusters2009
- Author(s)
  Utsumi M, Yamaguchi Y, Sasakawa H, Yamamoto N, Yanagisawa K, Kato K.
- Journal Title
  
  Glycoconjugate J. 26
  
  Pages: 999-1006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] ate endocytic dysfunction as a putative cause of amyloid fibril formation in Alzheimer's disease2009
- Author(s)
  Yuyama K, Yanagisawa K.
- Journal Title
  
  J. Neurochem 109
  
  Pages: 1250-1260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Novel role of presenilins in maturation and transport of integrin β1.2008
- Author(s)
  Zou K, (Yanagisawa K) et al.
- Journal Title
  
  Biochemistry 47
  
  Pages: 3370-3378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid s-protein fibrillogenesis2008
- Author(s)
  Yamamoto N, Matusbara T, Sato T. Yanagisawa K.
- Journal Title
  
  Biochim. Biophys. Acta 1778
  
  Pages: 2717-2726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Novel role of presenilins in maturation and transport of integrin β1.2008
- Author(s)
  Zou K, (Yanagisawa K), et al.
- Journal Title
  
  Biochemistry 47
  
  Pages: 3370-3378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] ccelerated release of exosome-associated GM1 ganglioside (GM1) by endocytic pathway abnormality: another putative pathway for GM1-induced amyloid fibril formation2008
- Author(s)
  Yuyama K, Yamamoto N, Yanagisawa K.
- Journal Title
  
  J. Neurochem 105
  
  Pages: 217-224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid β-protein fibrillogenesis.2008
- Author(s)
  Yamamoto N, (Yanagisawa K), et al.
- Journal Title
  
  Biochim Biophys Acta 1778
  
  Pages: 2717-2726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Accelerated release of exosome-associated GM1 ganglioside (GM1) by endocytic pathway abnormality : another putative pathway for GM1-induced amyloid fibril formation.2008
- Author(s)
  Yuyama K, (Yanagisawa K) et al.
- Journal Title
  
  J. Neurochem 105
  
  Pages: 217-214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] A ganglioside -induced toxic soluble As assembly: Its enhanced formation from As bearing theArctic mutation2007
- Author(s)
  amamoto N, Matsubara E, Maeda S, Minagawa H, Takashima A, Maruyama W, Michikawa M, Yanagisawa, K.
- Journal Title
  
  J. Biol. Chem 282
  
  Pages: 2646-2656
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] A ganglioside-induced toxic soluble Aβ assembly: Its enhanced formation from Aβ bearing the Arctic mutation.2007
- Author(s)
  Yamamoto N, (Yanagisawa K), et. al.
- Journal Title
  
  J Biol Chem 282
  
  Pages: 2646-2655
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] GM1-ganglioside-induced Aβ assembly on synaptic membranes of culturedneurons.2007
- Author(s)
  Yamamoto N, (Yanagisawa K), et. al.
- Journal Title
  
  Biochim Biophys Acta 1768
  
  Pages: 1128-1137
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Angiotensin-converting enzyme converts Aβ1-42 to Aβ1-40 and its inhibition enhances brain Aβ deposition.2007
- Author(s)
  Zou K, (Yanagisawa K) et al,
- Journal Title
  
  J. Neurosci. 27
  
  Pages: 8628-8635
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Novel action of apolipoprotein E (ApoE) : ApoE isoform specifically inhibits lipid-particle-mediated cholesterol release from neurons.2007
- Author(s)
  Gong J, (Yanagisawa K) et al.
- Journal Title
  
  Molecular Neurodegeneration 2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] GM1-ganglioside-induced Aβ assembly on synaptic membranes of cultured neurons.2007
- Author(s)
  Yamamoto N, (Yanagisawa K) et al.
- Journal Title
  
  Biochim. Biophys. Acta 1768
  
  Pages: 1128-1137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] GM1-ganglioside-induced As assembly on synaptic membranes of cultured neurons2007
- Author(s)
  Yamamoto N, Fukata Y, Fukata M, Yanagisawa K.
- Journal Title
  
  Biochim. Biophys. Acta 1768
  
  Pages: 1128-1137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Role of gangliosides in Alzheimer's disease.2007
- Author(s)
  Yanagisawa K.
- Journal Title
  
  Biochim. Biophys. Acta 1768
  
  Pages: 1943-1951
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Endosomal accumulation of GM1-ganglioside-bound amyloid β-protein inneurons of aged monkey brains.2007
- Author(s)
  Kimura N & Yanagisawa K.
- Journal Title
  
  Neuroreport 18
  
  Pages: 1669-1673
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Chloroquine-induced endocytic pathway abnormalities: cellular model of GM1 -ganglioside-induced As fibrillogenesis in Alzheimer's disease2006
- Author(s)
  Yuyama K, Yamamoto N, Yanagisawa K.
- Journal Title
  
  FEBS Lett 580
  
  Pages: 6972-6976
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Chloroquine-induced endocytic pathway abnormalities: Cellular model of GM1 ganglioside-induced Aβ fibrillogenesis in Alzheimer's disease.2006
- Author(s)
  Yuyama K, (Yanagisawa K), et. al.
- Journal Title
  
  FEBS Lett 580
  
  Pages: 6972-6976
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Further evidence of local ganglioside-dependent amyloid β-protein assembly in brain.2006
- Author(s)
  Yamamoto N, (Yanagisawa K), et. al.
- Journal Title
  
  Neuroreport 17
  
  Pages: 1735-1737
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Murine synaptosomal lipid raft protein and lipid composition are altered by expression of human apoE 3 and 4 and by increasing age.2005
- Author(s)
  Igbavboa U, (Yanagisawa K) et al.
- Journal Title
  
  J Neurol Sci 229
  
  Pages: 225-232
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Age-related changes of intracellular Aβ in cynomolgus monkey brains.2005
- Author(s)
  Kimura N, (Yanagisawa K) et al.
- Journal Title
  
  Neuropathol Applied Neurobiol 31
  
  Pages: 170-180
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Cross-seeding of wild- and hereditary variant-type amyloid β-proteins in the presence of gangliosides.2005
- Author(s)
  Yamamoto N, (Yanagisawa K) et al.
- Journal Title
  
  J Neurochem 95
  
  Pages: 1167-1176
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Suppression of Aβ deposition in brain by peripharal administration of Fab fragments of anti-seed antibody.2005
- Author(s)
  Yamamoto N, (Yanagisawa K) et al.
- Journal Title
  
  Biochem Biophys Res Commun 335
  
  Pages: 45-47
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Altered cholesterol metabolism in Niemann-Pick type C mouse brains affectsmitochondrial function.2005
- Author(s)
  Yu W, (Yanagisawa K) et al.
- Journal Title
  
  J Biol Chem 280
  
  Pages: 11731-11739
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Altered cholesterol metabolism in Niemann-Pick Type C1 mouse brain affects mitochondria function.2005
- Author(s)
  Yu W, (Yanagisawa K) et al.
- Journal Title
  
  J Biol Chem 280
  
  Pages: 11731-11739
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Age-related changes of intracellular Aβ in cynomolgus monkey brains.2005
- Author(s)
  Kimura N, (Yanagisawa K) et al.
- Journal Title
  
  Neuropath Applied Neurobiol 31
  
  Pages: 170-180
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Suppression of As deposition in brain by peripheral administration of Fab fragments of anti-seed antibody2005
- Author(s)
  Yamamoto N, Yokoseki T, Shibata M, Yamaguchi H, Yanagisawa K.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 335
  
  Pages: 45-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Neurodegeneration in heterogenous Niemann-Pick type C1 (NPC1) mouse : implication of heterogenous NPC1 mutations being a risk for tauopathy.2005
- Author(s)
  Yu W, (Yanagisawa K) et al.
- Journal Title
  
  J Biol Chem 280
  
  Pages: 27296-27302
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Assembly of hereditary amyloid β-protein variants in the presence of favorable gangliosides.2005
- Author(s)
  Yamamoto N, (Yanagisawa K) et al.
- Journal Title
  
  FEBS Lett 579
  
  Pages: 2185-2190
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Assembly of hereditary amyloid Β-protein variants in the presence of favourable gangliosides.2005
- Author(s)
  Yamamoto N, (Yanagisawa K) et al.
- Journal Title
  
  FEBS Lett 579
  
  Pages: 2185-2190
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Oligomerization of amyloid β-protein occurs during the isolation of lipid rafts.2005
- Author(s)
  Yu W, (Yanagisawa K) et al.
- Journal Title
  
  J Neurosci Res 80
  
  Pages: 114-119
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Cross seeding of wild- and hereditary variant-type amyloid s-proteins in the presence of gangliosides2005
- Author(s)
  Yamamoto N, Matsuzaki K, Yanagisawa K.
- Journal Title
  
  J. Neurochem. 95
  
  Pages: 1167-1176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Altered cholesterol metabolism in Niemann-Pick Type Cl mouse brain affects mitochondria function.2005
- Author(s)
  Yu W, (Yanagisawa K) et al.
- Journal Title
  
  J Biol Chem 280
  
  Pages: 11731-11739
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Murine synaptosomal lipid raft protein and lipid composition are altered by expression of humanapoE3 and 4 and by increasing age.2005
- Author(s)
  Igbavboa U, (Yanagisawa K) et al.
- Journal Title
  
  J Neurol Sci 229
  
  Pages: 225-230
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Assembly of hereditary amyloid s-protein variants in the presence of favorable gangliosides2005
- Author(s)
  Yamamoto N, Hirabayashi Y, Amari M, Yamaguchi H, Romanov G, Van Nostr, W.E., Yanagisawa K.
- Journal Title
  
  FEBS Lett 579
  
  Pages: 2185-2190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Assembly of hereditary amyloid β-protein variants in the presence of favorable gangliosides.2005
- Author(s)
  Yamamoto N, (Yanagisawa K) et al.
- Journal Title
  
  FEBS Lett 579
  
  Pages: 2185-2190
- Data Source
  KAKENHI-PROJECT-17025057
[Journal Article] Accelerated AR aggregation in the presence of GM1-ganglioside-accumulated synaptosomes of aged apoE4-knock-in mouse brain.2004
- Author(s)
  Yamamoto N, (Yanagisawa K) et al.
- Journal Title
  
  FEES Lett 569
  
  Pages: 135-139
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] PEN-2 enhances γ-cleavage after presenilin heterodimer formation.2004
- Author(s)
  Shiraishi H, (Yanagisawa K) et al.
- Journal Title
  
  J Neurochem 90
  
  Pages: 1402-1413
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] PEN-2 enhances g-cleavage after presenilin heterodimer formation.2004
- Author(s)
  Shiraishi H, (Yanagisawa K) et al.
- Journal Title
  
  J Neurochem 90
  
  Pages: 1402-1413
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Modulation of amyloid precursor protein cleavage by cellular sphingolipid.2004
- Author(s)
  Sawamura N, (Yanagisawa K) et al.
- Journal Title
  
  J Biol Chem 279
  
  Pages: 11984-11991
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Environment-and mutation-dependent aggregation behavior of Alzheimer amyloid β-protein.2004
- Author(s)
  Yamamoto N, (Yanagisawa K) et al.
- Journal Title
  
  J Neurochem 90
  
  Pages: 62-69
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] A seed for Alzheimer amyloid in the brain.2004
- Author(s)
  Hayashi H, (Yanagisawa K) et al.
- Journal Title
  
  J Neurosci 24
  
  Pages: 4894-4902
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Modulation of amyloid precursor protein cleavage by cellular sphing olipid2004
- Author(s)
  Sawamura N, (Yanagisawa K) et al.
- Journal Title
  
  J Biol Chem 279
  
  Pages: 11984-11991
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Accelerated Aβ aggregation in the presence of GM1-ganglioside-accumulated synaptosomes of aged apoE4-knock-in mouse brain.2004
- Author(s)
  Yamamoto N, (Yanagisawa K) et al.
- Journal Title
  
  FEBS Lett 569
  
  Pages: 135-139
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Environment- and mutation-dependent aggregation behavior of Alzheimer amyloid β-protein.2004
- Author(s)
  Yamamoto N, (Yanagisawa K) et al.
- Journal Title
  
  J Neurochem 90
  
  Pages: 62-69
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] The ubiquitin-like domain of Herp is involved in Herp degradation, but not necessary for its enhancement of amyloid β-protein generation.2003
- Author(s)
  Sai X, (Yanagisawa K) et al.
- Journal Title
  
  FEBS Lett 553
  
  Pages: 151-156
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Amyloid β-protein (Aβ)1-40 protects neurons from damage induced by Aβ1-42 in culture and in rat brain.2003
- Author(s)
  Zou K, (Yanagisawa K) et al.
- Journal Title
  
  J Neurochem 87
  
  Pages: 609-619
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Promotion of tau phosphorylation by MAP Kinase Erk1/2 Is accompanied by reduced cholesterol level in detergent-Insoluble membrane domains in Niemann-Pick C1-deficient cells.2003
- Author(s)
  Sawamura N, (Yanagisawa K) et al.
- Journal Title
  
  J Neurochem 84
  
  Pages: 1086-1096
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Promotion of tau phosphorylation by MAP kinase erkl/2 is accompanied by reduced cholesterol level in detergent-insoluble membrane domains in Niemann-Pick C1-deficient cells.2003
- Author(s)
  Sawamura N, (Yanagisawa K) et al.
- Journal Title
  
  J Neurochem 84
  
  Pages: 1086-1096
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] A novel function of monomeric amyloid β-protein serving as an antioxidant molecule against metal-induced oxidative damage.2002
- Author(s)
  Zou K, (Yanagisawa K) et al.
- Journal Title
  
  J Neurosci 22
  
  Pages: 4833-4831
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] A novel function of monomeric amyloid β-protein serving as an antioxidant molecule aeainst metal-induced oxidative damage.2002
- Author(s)
  Zou K, (Yanagisawa K) et al.
- Journal Title
  
  J Neurosci 22
  
  Pages: 4833-4841
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Interactions of amyloid β-protein with various gangliosides in raft like membranes : Importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid.2002
- Author(s)
  Kakio A, (Yanagisawa K) et al.
- Journal Title
  
  Biochemistry 23
  
  Pages: 7385-7390
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Cholesterol is increased in the exofacial leaflet of synaptic plasma membranes of human apolipoprotein E4 knock-in mice.2002
- Author(s)
  Hayashi H, (Yanagisawa K) et al.
- Journal Title
  
  Neuroreport 13
  
  Pages: 383-386
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Endoplasmic reticulum stess-inducible protein, Herp, enhances presenilin-mediated generation of amyloid β-protein.2002
- Author(s)
  Sai X, (Yanagisawa K) et al.
- Journal Title
  
  J Biol Chem 277
  
  Pages: 12915-12920
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Apolipoprotein E (apoE) isoform-dependent lipid release from astrocytes prepared from human-apoE3-and apoE4-knock-in mice.2002
- Author(s)
  Gong JS, (Yanagisawa K) et al.
- Journal Title
  
  J Biol Chem 277
  
  Pages: 29919-29926
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Cholesterol and pathological processes in Alzheimer's disease.2002
- Author(s)
  Yanagisawa K.
- Journal Title
  
  J Neurosci Res 70
  
  Pages: 361-366
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Amyloid β-protein affects cholesterol metabolism in cultured neurons : Implications for pivotal role of cholesterol in the amyloid cascade.2002
- Author(s)
  Gong JS, (Yanagisawa K) et al.
- Journal Title
  
  J Neurosci Res 70
  
  Pages: 438-466
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Cholesterol-dependent modulation of dendrite outgrowth and microtubule stability in cultured neurons.2002
- Author(s)
  Fan QW, (Yanagisawa K) et al.
- Journal Title
  
  J Neurochem 80
  
  Pages: 178-190
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] A new functional screening system for identification of regulators for the generation of amyloid β-protein.2002
- Author(s)
  Komano H, (Yanagisawa K) et al.
- Journal Title
  
  J Biol Chem 277
  
  Pages: 39627-39633
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Apolipoprotein E (apoE) isoform-dependent lipid release from astrocytes prepared from human-apoE3- and apoE4-knock-in mice.2002
- Author(s)
  Gong JS, (Yanagisawa K) et al.
- Journal Title
  
  J Biol Chem 277
  
  Pages: 29919-29926
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Cholesterol-dependent formation of GM1 ganglioside-bound amyloid β-protein, an endogenous seed for Alzheimer amyloid.2001
- Author(s)
  Kakio A, (Yanagisawa K, Matsuzaki K) et al.
- Journal Title
  
  J Biol Chem 276
  
  Pages: 24985-24990
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] A novel action of Alzheimer's amyloid β-protein (Aβ) : oligomeric Aβ promotes lipid release.2001
- Author(s)
  Michikawa M, (Yanagisawa K) et al.
- Journal Title
  
  J Neurosci 21
  
  Pages: 7226-7235
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Cholesterol-dependent formation of GM1 ganglioside-bound amyloid β-protein an endogenous seed for Alzheimer amyloid.2001
- Author(s)
  Kakio A, (Yanagisawa K, Matsuzaki K) et al.
- Journal Title
  
  J Biol Chem 276
  
  Pages: 24985-24990
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Site-specific phosphorylation of tau accompanied by activation of mitogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C mice.2001
- Author(s)
  Sawamura N, (Yanagisawa K) et al.
- Journal Title
  
  J Biol Chem 276
  
  Pages: 10314-10319
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Cholesterol-dependent microtubule stabilization by modulating tau phosphorylation.2001
- Author(s)
  Fan Q-W, ( Yanagisawa K ) et al.
- Journal Title
  
  J Neurochem 76
  
  Pages: 391-400
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] A novel action of Alzheimer's amyloid β-protein (Aβ) : oligomeric Aβ promotes lipid release.2001
- Author(s)
  Michikawa M, (Yanagisawa K) et al.
- Journal Title
  
  J Neurosci 21(18)
  
  Pages: 7226-7235
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Inhibitory effect of a presenilin 1 mutation on the Wnt signalling pathway by enhancement of β-catenin phosphorylation.2001
- Author(s)
  Kawamura Y, (Yanagisawa K) et al.
- Journal Title
  
  Eur J Biochem 268
  
  Pages: 3036-3041
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Cholesterol-dependent microtubule stabilization by modulating tau phosphorylation.2001
- Author(s)
  Fan Q-W, (Yanagisawa K) et al.
- Journal Title
  
  J Neurochem 76
  
  Pages: 391-400
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] 3-(4,5-Dimethylthiazol-2-yl)-2,5-dipenyltetrazolium bromide (MTT) causes Akt phosphorylation and morphological changes in intracellular organellae in cultured rat astrocytes.2001
- Author(s)
  Isobe I, (Yanagisawa K) et al.
- Journal Title
  
  J Neurochem 77
  
  Pages: 274-280
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] 3-(4,5-Dimethylthiazol-2-y1)-2,5-dipenyltetrazolium bromide (MTT) causes Akt phosphorylation and morphological changes in intracellular organellae in cultured rat astrocytes.2001
- Author(s)
  Isobe I, (Yanagisawa K) et al.
- Journal Title
  
  J Neurochem 77
  
  Pages: 274-280
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210022
[Journal Article] Extracellular and intraneuronal HMW-Abeta Os represent a molecular basis of memory loss in Alzheimer's disease model mouse.
- Author(s)
  Takamura Y, (Yamamoto N, Yanagisawa K), et al.
- Journal Title
  
  Mol Neurodegener
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300118
[Patent] Antibody Having Inhibitory Effect on AmyloidFibri Formation.2008
- Inventor(s)
  柳澤勝彦, 柴田昌夫
- Industrial Property Rights Holder
  柳澤勝彦, (株)医学生物学研究所, 国立長寿医療センター総長
- Acquisition Date
  2008-03-08
- Overseas
- Data Source
  KAKENHI-PROJECT-17025057
[Patent] GM1ガングリオシド結合型アミロイドタンパク質を認識する抗体を含有するアミロイド繊維形成抑制剤2008
- Inventor(s)
  柳澤勝彦, 柴田昌夫
- Industrial Property Rights Holder
  柳澤勝彦, (株)医学生物学研究所, 国立長寿医療センター総長
- Acquisition Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-17025057
[Patent] Antibody Recognizing GM1 Ganglioside-Bound Amyloid β-Protein and DNA Encoding The Antibody2008
- Inventor(s)
  柳澤勝彦, 柴田昌夫
- Industrial Property Rights Holder
  柳澤勝彦, (株)医学生物学研究所, 国立長寿医療センター総長
- Acquisition Date
  2008-03-04
- Overseas
- Data Source
  KAKENHI-PROJECT-17025057
[Patent] 可溶性アミロイドs蛋白重合体の調整法ならびに毒性評価法2006
- Inventor(s)
  柳澤勝彦、山本直樹
- Industrial Property Rights Holder
  ヒューマンサイエンス振興財団
- Filing Date
  2006-06-05
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] Role of lipids in the development of Alzheimer pathology2012
- Author(s)
  Yanagisawa K.
- Organizer
  International Conference on Alzheimer's Disease.
- Place of Presentation
  Tianjin, China.
- Year and Date
  2012-09-18
- Data Source
  KAKENHI-PROJECT-22300118
[Presentation] アミロイドベータの凝集機構の解明のためのGM1含有生体膜モデルの構築2012
- Author(s)
  福田竜統, 小島昂大, 松原輝彦, 山本直樹, 柳澤勝彦, 佐藤智典
- Organizer
  日本化学会第92春季年会(2012)
- Place of Presentation
  慶應義塾大学(横浜)
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-22300118
[Presentation] Investigating rare lysosomal storage disorders to elucidate the sphingolipidosis-proteinopathy connection in common neurodegenerative disorders2011
- Author(s)
  Wustman B.A., et al.(Yanagisawa K)
- Organizer
  Neuroscience Meeting 2011
- Place of Presentation
  Washington Convention Center. (Washington DC.USA)
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-22300118
[Presentation] 認知症とうつ病～神経病理学の観点から～2011
- Author(s)
  柳澤勝彦
- Organizer
  日本うつ病学会緊急シンポジウム「うつ病克服へのロードマップ」
- Place of Presentation
  新宿明治安田生命ホール(東京)(招待講演)
- Year and Date
  2011-12-18
- Data Source
  KAKENHI-PROJECT-22300118
[Presentation] 治療戦略:最近の知見からみた治療開発の展望2011
- Author(s)
  柳澤勝彦
- Organizer
  第29回日本神経治療学会
- Place of Presentation
  フェニックスプラザ(福井)(招待講演)
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-22300118
[Presentation] Ganglioside-induced conformational change of amyloid ss-protein as an initial step in the process of Alzheimer disease2011
- Author(s)
  Yanagisawa K.
- Organizer
  The 31^<st> Naito Conference on GlycanExpression and Regulation.〔II〕 : Metabolites, Stress Response, Microdomains, and Beyond
- Place of Presentation
  シャトーレーゼガトーキングダムサッポロ(北海道)(招待講演)
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22300118
[Presentation] GM1含有脂質膜におけるアミロイドベータの凝集機構の解析2011
- Author(s)
  小島昂大, 松原輝彦, 山本直樹, 柳澤勝彦, その他
- Organizer
  日本化学会第91春季年会
- Place of Presentation
  神奈川大学(神奈川県)
- Year and Date
  2011-03-15
- Data Source
  KAKENHI-PROJECT-22300118
[Presentation] Ganglioside-induced conformational change of amyloid ss-protein as an initial step in the process of Alzheimer disease2011
- Author(s)
  Yanagisawa K.
- Organizer
  The 31st Naito Conference on Glycan -Expression and Regulation. 〔II〕: Metabolites, Stress Response, Microdomains, and Beyond
- Place of Presentation
  シャトーレーゼガトーキングダムサッポロ,北海道
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22300118
[Presentation] アルツハイマー病の治療:現状と展望2011
- Author(s)
  柳澤勝彦
- Organizer
  第107回日本精神神経学会学術総会シンポジウム「認知症、これからの診断、治療-新たな抗アルツハイマー病薬の出現をへて-」
- Place of Presentation
  ホテルグランパシフィック1E DAIBA(東京都)(招待講演)
- Year and Date
  2011-10-26
- Data Source
  KAKENHI-PROJECT-22300118
[Presentation] Molecular Mechanism Underlying Initiation of Development of Alzheimer Disease and Therapeutic Strategy2011
- Author(s)
  Yanagisawa K.
- Organizer
  German Reserach and Innovation Forum. German-Japanese Symposium on Ageing and Neurodegeneration
- Place of Presentation
  ウェスティンホテル大阪(大阪府)(招待講演)
- Year and Date
  2011-12-12
- Data Source
  KAKENHI-PROJECT-22300118
[Presentation] 神経細胞endocytosis障害によるGM1ガングリオシド誘導性アミロイドss蛋白重合の促進2010
- Author(s)
  湯山耕平、柳澤勝彦
- Organizer
  第29回日本認知症学会学術集会
- Place of Presentation
  ウィンクあいち(愛知県)
- Year and Date
  2010-11-05
- Data Source
  KAKENHI-PROJECT-22300118
[Presentation] NMR法を用いたアミロイドβとガングリオシドクラスターの相互作用解析2010
- Author(s)
  矢木真穂,(柳澤勝彦)
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] Pathological significance of ganglioside cluster in Alzheimer disease.2009
- Author(s)
  柳澤勝彦
- Organizer
  第51回日本脂質生化学会
- Place of Presentation
  名古屋
- Year and Date
  2009-07-30
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] NMR法によるアミロイドペプチドとGM1ガングリオシドクラスターとの相互作用解析2009
- Author(s)
  矢木-内海真穂,(柳澤勝彦)
- Organizer
  第7回「若手の力」フォーラムおよび拠点共同研究報告会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-30
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] NMR analyses of interaction mode of amyloid -peptide with GM1 ganglioside clusters2009
- Author(s)
  Yagi-Utsumi M,(Yanagisawa K)
- Organizer
  3rd Asia-Pacific NMR Symposium
- Place of Presentation
  韓国チェジュ島
- Year and Date
  2009-10-26
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] アルツハイマー病におけるGM1ガングリオシド誘導性アミロイドs蛋白質重合に関与する後期エンドサイトーシス障害2009
- Author(s)
  湯山耕平, 柳澤勝彦
- Organizer
  第52回日本神経化学会大会
- Place of Presentation
  渋川
- Year and Date
  2009-06-22
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] Seed形成の細胞生物学的基礎:ガングリオシドマイクロドメインの役割2009
- Author(s)
  柳澤勝彦
- Organizer
  大阪大学蛋白質研究所セミナー「蛋白質立体構造を基盤とするプリオン現象の解明と制御」
- Place of Presentation
  吹田
- Year and Date
  2009-07-13
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] アルツハイマー病におけるGM1ガングリオシド誘導性アミロイドβ蛋白質重合に関与する後期エンドサイトーシス障害2009
- Author(s)
  湯山耕平,(柳澤勝彦)
- Organizer
  第52回日本神経化学会大会
- Place of Presentation
  渋川
- Year and Date
  2009-06-22
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] Aβ線維化に関与するGM1ガングリオシド集積を誘導するエンドサイトーシス径路傷害2008
- Author(s)
  柳澤勝彦
- Organizer
  第51回日本神経化学会大会
- Place of Presentation
  富山
- Year and Date
  2008-09-12
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] GM1ガングリオシドのエンドサイトーシス制御によるアルツハイマー病細胞モデルの構築2008
- Author(s)
  湯山耕平、(柳澤勝彦)
- Organizer
  糖鎖機能研究会
- Place of Presentation
  岡崎
- Year and Date
  2008-05-22
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] カニクイザル脳におけるアルツハイマー病関連蛋白(As、タウ)の解析2008
- Author(s)
  及川尚人, 木村展之, 柳澤勝彦
- Organizer
  第27回日本認知症学会
- Place of Presentation
  前橋
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] シナプス前膜の年齢依存的なGM1 ganglioisde集積ドメイン形成はAs線維化を促す2008
- Author(s)
  山本直樹, 松原輝彦, 湯山耕平, 佐藤智典, 柳澤勝彦
- Organizer
  第51回日本神経化学会大会
- Place of Presentation
  富山
- Year and Date
  2008-09-12
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] カニクイザル脳におけるアルツハイマー病関連蛋白(Aβ、タウ)の解析2008
- Author(s)
  及川尚人、(柳澤勝彦)
- Organizer
  第27回日本認知症学会
- Place of Presentation
  前橋
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] Ganglioside-induced Aβ assembly as an early event of Alzheimer's disease.2008
- Author(s)
  Yanagisawa K.
- Organizer
  10th International Hong Kong/Spreingfield Pan-Asian Symposium on Advances on Alzheimer Therapy
- Place of Presentation
  Hong Kong
- Year and Date
  2008-03-01
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] シナプス前膜の年齢依存的なGM1 ganglioside集積ドメイン形成はAβ線維化を促す2008
- Author(s)
  山本直樹、(柳澤勝彦)
- Organizer
  第51回日本神経化学会大会
- Place of Presentation
  富山
- Year and Date
  2008-09-12
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] Aβ重合開始の分子機構2008
- Author(s)
  柳澤勝彦
- Organizer
  第51回日本神経化学会大会
- Place of Presentation
  富山
- Year and Date
  2008-09-12
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] Aβ線維化に関与するGM1ガングリオシド集積を誘導するエンドサイトーシス経路障害2008
- Author(s)
  湯山耕平、(柳澤勝彦)
- Organizer
  第51回日本神経化学会大会
- Place of Presentation
  富山
- Year and Date
  2008-09-12
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] As線維化に関与するGM1ガングリオシド集積を誘導するエンドサイトーシス経路障害2008
- Author(s)
  湯山耕平, 山本直樹, 柳澤勝彦
- Organizer
  第51回日本神経化学会大会
- Place of Presentation
  富山
- Year and Date
  2008-09-21
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] アルツハイマー病 - Up date.2007
- Author(s)
  柳澤勝彦
- Organizer
  第22回日本老年精神医学会
- Place of Presentation
  大阪
- Year and Date
  2007-10-16
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] A ganglioside-induced soluble As assembly causes neuronal death through NGF receptors2007
- Author(s)
  Yamamoto N, Matsubara E, Maeda S, Minagawa H, Takashima A, Michikawa M, Yanagisawa K.
- Organizer
  37th Society for Neuroscience Annual Meeting
- Place of Presentation
  サンディエゴ, アメリカ
- Year and Date
  2007-11-05
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] アミロイドβペプチド・GM1ガングリオシド相互作用系のNMR解析2007
- Author(s)
  内海真穂、(柳澤勝彦)、その他
- Organizer
  第27回日本糖質学会年会
- Place of Presentation
  福岡
- Year and Date
  2007-08-02
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] A ganglioside-induced toxic soluble Aβ assembly.2007
- Author(s)
  柳澤勝彦
- Organizer
  第257回東北大学薬学研究科セミナー
- Place of Presentation
  仙台
- Year and Date
  2007-11-09
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] PC12細胞エンドーシス径路障害時におけるGM1ガングリオシドの細胞外放出2007
- Author(s)
  湯山耕平、(柳澤勝彦)、その他
- Organizer
  第27回日本糖質学会年会
- Place of Presentation
  福岡
- Year and Date
  2007-08-02
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] 細胞膜脂質とアルツハイマー病2007
- Author(s)
  柳澤勝彦
- Organizer
  第29回日本フリーラジカル学会・第31回日本過酸化脂質フリーラジカル学会合同大会
- Place of Presentation
  名古屋
- Year and Date
  2007-06-09
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] 老齢マウス脳シナプス膜中の特異なGM1 ganglioside集積ドメイン2007
- Author(s)
  山本直樹, 湯山耕平, 柳澤勝彦
- Organizer
  50回日本神経化学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-09-10
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] Ganglioside-induced Aβ assembly in Alzheimer disease.2007
- Author(s)
  Yanagisawa K.
- Organizer
  Inangural Meeting of the Korea Society for Neuro degenerative Disorder.
- Place of Presentation
  Seoul, Korea
- Year and Date
  2007-04-14
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] 安定同位体利用NMR法によるGM1ミセル結合型アミロイドβの構造解析2007
- Author(s)
  内海真穂、(柳澤勝彦)、その他
- Organizer
  第50回日本神経化学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-09-10
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] アミロイドβ蛋白の構造変化とアルツハイマー病2007
- Author(s)
  柳澤勝彦
- Organizer
  第7回日本タンパク質科学会年会
- Place of Presentation
  仙台
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] アルツハイマー病の分子病理と治療戦略2007
- Author(s)
  柳澤勝彦
- Organizer
  第23回創薬セミナー
- Place of Presentation
  長野
- Year and Date
  2007-07-25
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] 脳内Aβ蓄積の時空間的特性の基盤:細胞膜脂質環境の重要性2007
- Author(s)
  柳澤勝彦
- Organizer
  第26回日本認知症学会シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2007-10-17
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] エンドサイトーシス経路異常によるGM1ガングリオシドの細胞外放出の促進2007
- Author(s)
  湯山耕平, 山本直樹, 柳澤勝彦
- Organizer
  第50回日本神経化学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-09-10
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] エンドサイトーシス径路異常によるGM1ガングリオシドの細胞外放出の促進2007
- Author(s)
  湯山耕平、(柳澤勝彦)、その他
- Organizer
  第50回日本神経化学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-09-10
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] 老齢マウス脳シナプス膜中の特異なGM1 ganglioside 集積ドメイン2007
- Author(s)
  山本直樹、(柳澤勝彦)、その他
- Organizer
  第50回日本神経化学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-09-10
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] A ganglioside-induced soluble Aβ assembly causes neuronal death through NGF receptors.2007
- Author(s)
  Yamamoto N, (Yanagisawa K) et al.
- Organizer
  37th Society for Neuroscience Annual Meeting
- Place of Presentation
  San Diego, U. S. A.
- Year and Date
  2007-11-05
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] アルツハイマー病発祥と神経細胞膜脂質2007
- Author(s)
  柳澤勝彦
- Organizer
  第16回日本脂質栄養学会シンポジウム
- Place of Presentation
  島根
- Year and Date
  2007-08-31
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] A ganglioside-induced toxic soluble As assemblycauses neuronal death2006
- Author(s)
  山本直樹, 松原悦朗, 前田純裕, 高島明彦, 丸山和佳子, 道川誠, 柳澤勝彦
- Organizer
  第29回日本分子生物学会年会
- Place of Presentation
  名古屋
- Year and Date
  2006-12-06
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] GM1 ganglioside accumulation in PC12 cells treated with chloroquine: a cellular model of As assembly2006
- Author(s)
  湯山耕平, 山本直樹, 柳澤勝彦
- Organizer
  第49回日本神経化学大会
- Place of Presentation
  名古屋
- Year and Date
  2006-09-14
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] GM1-ganglioside-induced As assembly at neuritic terminals of nerve growth factor-treated PC12 cells2006
- Author(s)
  山本直樹, 湯山耕平, 柳澤勝彦
- Organizer
  第49回日本神経化学大会
- Place of Presentation
  名古屋
- Year and Date
  2006-09-14
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] アミロイドs蛋白重合とガングリオシド2005
- Author(s)
  柳澤勝彦
- Organizer
  第28回日本神経科学大会シンポジウム「糖鎖科学と神経科学の融合による新展開」
- Place of Presentation
  横浜
- Year and Date
  2005-07-27
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] Pivotal roles of lipids in generating an endogenous seed for Alzheimer amyloid2005
- Author(s)
  Yanagisawa K.
- Organizer
  7th International Conference on Alzheimer's Disease and Parkinson Disease. Sorrento
- Place of Presentation
  イタリア
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] 膜マイクロドメインとアルツハイマー病:GM1ガングリオシド集積の意味2005
- Author(s)
  柳澤勝彦
- Organizer
  第28回日本分子生物学会
- Place of Presentation
  福岡
- Year and Date
  2005-12-10
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] Assembly of hereditary variant amyloid s-protein in the presence of gangliosides2005
- Author(s)
  Yamamoto N, Hirabayashi Y, Amari M, Yamaguchi H, Romanov G, Nostr, W, Yanagisawa K.
- Organizer
  第48回日本神経化学会
- Place of Presentation
  福岡
- Year and Date
  2005-09-28
- Data Source
  KAKENHI-PROJECT-17025057
[Presentation] Role of lipids in the development of Alzheimer pathology.
- Author(s)
  Yanagisawa K.
- Organizer
  International Conference on Alzheimer’s Disease.
- Place of Presentation
  Tianjin, China.
- Invited
- Data Source
  KAKENHI-PROJECT-22300118
[Presentation] Pathological significance of ganglioside cluster in Alzheimer disesse
- Author(s)
  柳澤勝彦
- Data Source
  KAKENHI-PROJECT-17025057

1. IHARA Yasuo (60114386)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. KATO Koichi (20211849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. MURAYAMA Shigeo (50183653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MATSUBARA Teruhiko (10325251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. YAMAMOTO Naoki (90393157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. MIYATAKE Tadashi (50048998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. UCHIHARA Toshiki (10223570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. R.C.PARK MATSUMOTO (60165917)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. IWATSUBO Takeshi (50223409)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAMAZAKI Tsuneo (80200658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MORISHIMA Maho (50204722)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YAMAGUCHI Haruyasu (00158114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SASAKI Atsushi (80225862)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 辻省次 (70150612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 松崎勝巳 (00201773)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 浦上克哉 (30213507)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. C.FUJITA Shinobu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KAWARABAYASHI Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 松崎勝己

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. 東海林幹夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YANAGISAWA Katsuhiko 柳澤 勝彦

Research Projects

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Co-Researchers

Study on molecular mechanism underlying brain region-specific Ass depositionPrincipal Investigator

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Molecular mechanism underlying Ass assembly in Alzheimer brain : pathological and therapeutic significance of an endogenous seed for amyloidPrincipal Investigator

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Influence of membrane lipid metabolism on cerebral amyloid deposition and neurodegeneration.

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An investigation into molecular mechanism underlying Aβ assemblyPrincipal Investigator

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アルツハイマー病脳におけるアミロイドβ蛋白蓄積の初期機構に関する生化学的研究Principal Investigator

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Studies on beta-amyloidogenesis-isolation of membrane-bound Abeta

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POSITIONAL CLONING OF CANDIDATE GENES

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[Book] Amyloid, arises on the membranes and acts on the membranes. In : Amyloids: Composition, Function and Pathology2012

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[Book] Amyloid, arises on the membranes and acts on the membranes. In:Amyloids: Composition, Function and Pathology (edited by Irene P. Halcheck and Nancy R. Vernon)2012

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[Book] Research Progress in Alzheimer's Disease(edited by Miao-Kun Sun, Pivotal roles of cholesterol and gangliosides in aggregation of amyloid β-protein.)2010

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[Book] Comprehensive Glycoscience(edited by Kamerling J.P., Boons G-J., Lee Y.C.,Suzuki A. and Taniguchi N., Glycoconjugates and neurological diseases.)2007

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[Book] Comprehensive Glycoscience2007

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[Book] Ganglioside and Alzheimer's Disease. In: Sphingolipid Biology2006

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[Book] Sphingolipid Biology.(edited by Hirabayashi Y, Igarashi Y and Merill AH, Ganglioside and Alzheimer's disease.)2006

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[Book] Pivotal roles of cholesterol and gangliosides in aggregation of amyloid β-protein. Research Progress in Alzheimer's Disease Interactions.2005

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[Book] Cholesterol and Aβ fibrillogenesis. In : Subcellular Biochemistry : Alzheimer's disease-Cellular2005

YANAGISAWA Katsuhiko 柳澤勝彦