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ICHIHARA Akira
市原 明
Connect your ORCID iD
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Alternative Names
MURAYAMA Akira
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Researcher Number
40035374
External Links
Affiliation (based on the past Project Information)
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1987 – 1993: 徳島大学, 酵素科学研究センター, 教授
1991: 徳島大学, 酵素研究所, 教授
1991: 徳島大学, 酵素科学研究所, 教授
1990: Inst. for Enz. Sci., Univ. of Tokushima, Professor, 酸素科学研究センター, 教授
1989 – 1990: 徳島大学, 酵素センター, 教授
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1989: Institute for Enzyme Research, University of Tokushima, Professor, 教授
1986: Tokyo Metropolitan Inst. of Med. Sci., Chief Researcher
1986: 徳島大, 医学部, 教授
1986: Univ. of Tokushima, School of Medicine, Professor, 医学部, 教授
1986: Institute for Enzyme Research Tokushima University, 酵素科学センター, 教授
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Review Section/Research Field
Principal Investigator
Pathological medical chemistry
/
General medical chemistry
Except Principal Investigator
医学一般
/
Pathological medical chemistry
/
Legal medicine
/
General medical chemistry
/
Biological pharmacy
Keywords
Principal Investigator
増殖因子 / 肝細胞 / 初代培養 / プロテアソ-ム / 増殖抑制因子 / プロテアソーム / 細胞周期 / 細胞膜調節因子 / 肝再生 / インターロイキン
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/ ユビキチン / 多機能プロテア-ゼ複合体 / 分化 / 初代培養肝細胞 / 細胞接触 / 遺伝子破壊 / 多機能プロテアーゼ / 多成分複合体 / DNA合成 / 細胞工学 / 高脂血症 / グルカゴン / cyclic AMP / 前癌状態 / エネルギー依存性分子識別 / Cell cycle / 細胞増殖・分化 / Supramolecular complex / 肝細胞の初代培養 / クロマチン / 細胞分化 / ステロイドホルモン / Structural analysis / Growth factors / 多機能プロテア-ゼ / MHCクラスエ拘束性抗原提示 / 肝細胞の増殖と分化 / 肝組織 / MHCクラスI拘束性抗原提示 / 増殖と機能 / Ubiquitin / 肝臓機能 / cDNAクロ-ニング / 白血病細胞 / ホルボル・エステル(TPA) / Multisubunit complex / cAMP / 遺伝子発現 / Interleukin-1beta / ガンマ型インターフェロン / 多機能プロテアーゼ複合体 / ホルボ-ルエステル / がん細胞 / Proteasome / エネルギー依存性蛋白質分解 / マイクロインジェクション / 超分子複合体 / 分子適合 / 転写因子 / Antigen Processing / 抗原プロセシング・提示 / 調節領域 / 分子遺伝学 / Multicatalytic protease / 遺伝子操作 / 癌胎児性蛋白 / Transforming growth factor(TGF)-beta / エネルギー依存性蛋白分解 / 肝細胞培養 / Transfoming Growth Factor(TGF-beta) / 細胞膜 / 蛋白分解酵素 / 組織構築 / 卵母細胞 / 細胞増殖調節 / Transforming growth factor(TGF)-β / 増殖制御因子 / 細胞増殖因子 / CAMP / 混合培養 / Hepatocytes / 細胞間相互作用 / Cell contact / Proteasomes / Interleukin(IL-1) / 血小板 / 細胞内蛋白質分解機構 / 細胞内プロテア-ゼ / 遺伝子転写制御機構 / 高分子量プロテア-ゼ / 抗原プロセシング / High molecular weight protease / インスリン / 活性型ビタミンD / 発生と分化 / 生物工学 / 糖新生 / 過形成腫粒 / 増殖 / ホルモン / エネルギ-依存性分子識別 / Energy-dependent proteolysis / ヒト単球 / 発現ベクタ- / 20S環状粒子 / MHC classI-restricted antigen presentation / ツメガエル卵の発現系 / Primary culture / 肝癌細胞 / 異常発現 / Gamma-interferon / 遺伝子 / サイクリックAMP / 細胞増殖 / Interleukin-1β / 蛋白復合体 / TGF-β / 構造解析 / 蛋白質超分子複合体 / Phorbol ester(TPA)
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Except Principal Investigator
細胞膜 / 細胞核 / カルパインペプチドの白血球遊走活性 / ステロイド・ホルモン / Gタンパク質 / エリスロポエチン様因子 / Hematocyte coagulation factor / Intracellular protease transport / カテプシンの細胞内選別輸送 / ステロイドホルモンレセプター / ペプチド合成 / 蛙卵によるmRNAの選別 / receptors / Erythropoietin-like factor / Metabolic regulation / カテプシンの抗原提示への関与 / Cellular responses / Calpain activation due to inafarotion / 情報伝達 / organella constituents / 膜結合性Gキナ-ゼ / 薬物 / 高物子物質注入 / 赤血球ゴースト法 / 細胞質因子 / ホルモン受容体 / 小胞体 / Cartilage-Derived Factor (CDF) / Limited proteolysis / カテプシンBの抗原阻囎への関与 / オルガネラ / 血小板由来増殖阻害因子 / 腫瘍増殖促進因子 / Cell nucleus / Bリンパ球分化因子 / アミロイドジェニックプロテアーゼ / 軟骨由来因子 / 遺伝子操作 / Fibroblast-derived Endothelial Cell Growth Factor (f-ECGF) / リン脂質合成欠損変異 / ニュ-カッスル病ウイルス / m‐RNA構造 / 26Sプロテアソ-ム / Platelet-Derived Growth Inhibitor (PDGI) / Amyloidogenic protease / スロンボモジュリンの発現調節 / リソソ-ム / プレプロタキキニン遺伝子発現調節因子 / 代謝制御機構 / cell membrane / Cキナーゼ / 受容体 / 筋組織特異的94Kカルパイン / gene regulation / プロテアーゼによる情報発現 / Testosterone / drugs / インスリン作用促進因子 / 細胞膜因子 / Tumor Growth Stimulating Activity (TGSA) / 筋原細胞の融合 / カルパインの活性化 / cell nucleus / 細胞膜タンパク質 / 血球内凝固因子 / 脂質輸送 / 脳梗塞巣活性化カルパイン / Lysosomes / Antigen presentation / 薬物応答 / 細胞質 / リソソーム / cytoplasm / 遺伝子発現調節レセプター / Endoplasmic reticulum / Thrombomodulin / Glucocorticoid / 代謝制御 / カテプシン-インバリアント鎖による抗原提示の調節 / トランスゴルジ膜結合性プロセシングプロテアーゼ / Cytoplasmic factors / G protein / 遺伝子調節 / 94K calpain / transduction / 筋組織特異的94Kカルバイン / 軟骨由来抗腫瘍因子 / Progesterone / Organella / 心筋梗塞巣活性化カルパイン / 筋組織特異的カルパイン / 線維芽細胞由来内皮細胞増殖因子 / プロテア-ゼによる情報発現 / プロガストリンの活性化 / Estrogen / トランスダクション / 細胞操作 / Cell membrane / Insulin-Stimulating Peptide (ISP) / Cartilage-derived Anti-Tumor Factor (CATF) / Steroid Hormone Receptor / オルガネラ構成因子 / ステロイド・ホルモン作用機構 / T細胞エイズレセプタ-
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Research Projects
(
19
results)
Co-Researchers
(
49
People)
Project Start Year (Newest)
Project Start Year (Oldest)
Studies on structure and the biological functions of a large multi-molecular complex "the proteasome"
Principal Investigator
Principal Investigator
ICHIHARA Akira
Project Period (FY)
1991 – 1993
Research Category
Grant-in-Aid for Specially Promoted Research
Research Institution
Institute for Enzyme Research, The University of Tokushima
Roles of proteases in signal transduction and their disorders
Principal Investigator
SASAKI Makoto
Project Period (FY)
1991 – 1993
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
Pathological medical chemistry
Research Institution
Nagoys City Unversity Medcal School
Co-operative Responses of Organella Constituents to Drug stimulation
Principal Investigator
OHBA Yoshiki
Project Period (FY)
1991 – 1993
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
Biological pharmacy
Research Institution
Kanazawa University
プロテアソ-ム(巨大蛋白分解酵素復合体)の構造解析と癌化における発現異常の解明
Principal Investigator
Principal Investigator
市原 明
Project Period (FY)
1990
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokushima
ホルモンによる遺伝子発現調節および病態に関する研究
Principal Investigator
Principal Investigator
市原 明
Project Period (FY)
1990
Research Category
Grant-in-Aid for Co-operative Research (B)
Research Field
Pathological medical chemistry
Research Institution
The University of Tokushima
培養肝細胞を用いた機能と増殖を調節する肝組織構築の生化学的研究
Principal Investigator
Principal Investigator
市原 明
Project Period (FY)
1990 – 1992
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Pathological medical chemistry
Research Institution
The University of Tokushima
多機能プロテアーゼ復合体(プロテアソーム)の機能と癌化における異常発現機構の解析
Principal Investigator
Principal Investigator
市原 明
Project Period (FY)
1989
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokushima
ホルモンによる遺伝子発現調節および病態に関する研究
Principal Investigator
Principal Investigator
市原 明
Project Period (FY)
1989
Research Category
Grant-in-Aid for Co-operative Research (B)
Research Field
Pathological medical chemistry
Research Institution
The University of Tokushima
肝細胞増殖制御因子の生物工学的技法による同定,遺伝子構造解析と大量生産のシステム化
Principal Investigator
Principal Investigator
市原 明
Project Period (FY)
1989 – 1991
Research Category
Grant-in-Aid for Developmental Scientific Research (B)
Research Field
General medical chemistry
Research Institution
The University of Tokushima
Structure and Cell Biology of a Novel Multicatalytic Proteinase Complex
Principal Investigator
Principal Investigator
ICHIHARA Akira
Project Period (FY)
1989 – 1990
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
General medical chemistry
Research Institution
The University of Tokushima
培養肝細胞を用いた増殖と分化の制御機構の研究
Principal Investigator
Principal Investigator
市原 明
Project Period (FY)
1988
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokushima
Analysis of Functional Cooperations between Organella in Responses to Medicines
Principal Investigator
ISHIBASHI Sadahiko.
Project Period (FY)
1988 – 1990
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
Legal medicine
Research Institution
Hiroshima University
培養肝細胞を用いた増殖と分化の制御機構の研究
Principal Investigator
Principal Investigator
市原 明
Project Period (FY)
1987
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokushima
細胞工学的手法によるヒトを含む高等動物細胞の体細胞遺伝生理学的研究
Principal Investigator
岡田 善雄
Project Period (FY)
1987
Research Category
Grant-in-Aid for Co-operative Research (B)
Research Field
医学一般
Research Institution
Osaka University
培養肝細胞を用いた増殖と分化の制御機構の研究
Principal Investigator
Principal Investigator
市原 明
Project Period (FY)
1986
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokushima
細胞工学的手法によるヒトを含む高等動物細胞の遺伝生理学的研究
Principal Investigator
岡田 善雄
Project Period (FY)
1986
Research Category
Grant-in-Aid for Co-operative Research (B)
Research Field
医学一般
Research Institution
Osaka University
Biochemical studies on tissue architecture of liver, which controls functions and growth, using primary cultured hepatocytes
Principal Investigator
Principal Investigator
ICHIHARA Akira
Project Period (FY)
1986 – 1989
Research Category
Grant-in-Aid for General Scientific Research (A)
Research Field
Pathological medical chemistry
Research Institution
University of Tokushima
Molecular Mechanism of Steroid Hormone Action and Modulation of Gene Expression
Principal Investigator
SAKAMOTO Yukiya
Project Period (FY)
1984 – 1986
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
General medical chemistry
Research Institution
Osaka University
Reaction mechanisms of various growth regulators and differentiation regulators and their clinical applications
Principal Investigator
SUZUKI Fujio
Project Period (FY)
1984 – 1986
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
Pathological medical chemistry
Research Institution
Osaka University
# of Projects (Dsc)
# of Projects (Asc)
1.
TANAKA Keiji
(10108871)
# of Collaborated Projects:
10 results
# of Collaborated Products:
0 results
2.
TOMITA Yumiko
(00089913)
# of Collaborated Projects:
8 results
# of Collaborated Products:
0 results
3.
NODA Chiseko
(40035506)
# of Collaborated Projects:
8 results
# of Collaborated Products:
0 results
4.
OHBA Yoshiki
(10012634)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
5.
中村 敏一
(00049397)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
6.
ISHIBASHI Sadahiko
(90012616)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
7.
NATORI Shunji
(50012662)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
8.
谷口 維紹
(50133616)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
9.
SASAKI Makoto
(10080003)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
10.
ICHIKAWA Atsushi
(10025695)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
11.
NOMURA Yasuyuki
(00034041)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
12.
森 正敬
(40009650)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
13.
市山 新
(90025601)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
14.
岡田 善雄
(30029756)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
15.
田代 裕
(40077558)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
16.
内田 驍
(40029781)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
17.
松原 謙一
(20037394)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
18.
新垣 理恵子
(00193061)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
19.
YOKOSAWA Hideyoshi
(90012765)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
20.
ISHIURA Shoichi
(10158743)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
21.
IKAI Atsushi
(50011713)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
22.
YOSHIMURA Tetsuro
(30035472)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
23.
OHKUBO Iwao
(80152073)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
24.
IWANAGA Sadaaki
(90029942)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
25.
SUZUKI Koichi
(80011948)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
26.
KATUNUMA Nobuhiko
(50035375)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
27.
OKAMOTO Hiroshi
(60025632)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
28.
SAKAMOTO Yukiya
(60028280)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
29.
ENDO Hiroyoshi
(50012604)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
30.
OTA Minoru
(70048255)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
31.
ICHII Shogo
(80032150)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
32.
SUZUKI Fujio
(40028717)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
33.
KISHIMOTO Tadamitsu
(10093402)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
34.
TAKEDA Yoshiro
(00028705)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
35.
TAKAKU Fumimaro
(40048955)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
36.
KATO Keitaro
(70037571)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
37.
尾形 悦郎
(70013761)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
38.
田中 武彦
(60028272)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
39.
藤井 義明
(00098146)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
40.
井村 裕夫
(10025570)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
41.
黒木 登志夫
(90006073)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
42.
石川 勝利
(00008608)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
43.
村地 孝
(10089104)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
44.
高橋 健治
(70011533)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
45.
木南 英紀
(10035496)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
46.
村山 昭
(10109952)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
47.
佐藤 威
(80125567)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
48.
赤松 穣
(00072900)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
49.
YAMANE Isao
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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