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ICHIHARA Akira
市原 明
Connect your ORCID iD
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Alternative Names
MURAYAMA Akira
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Researcher Number
40035374
External Links
Affiliation (based on the past Project Information)
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1987 – 1993: 徳島大学, 酵素科学研究センター, 教授
1991: 徳島大学, 酵素研究所, 教授
1991: 徳島大学, 酵素科学研究所, 教授
1990: Inst. for Enz. Sci., Univ. of Tokushima, Professor, 酸素科学研究センター, 教授
1989 – 1990: 徳島大学, 酵素センター, 教授
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1989: Institute for Enzyme Research, University of Tokushima, Professor, 教授
1986: Tokyo Metropolitan Inst. of Med. Sci., Chief Researcher
1986: 徳島大, 医学部, 教授
1986: Univ. of Tokushima, School of Medicine, Professor, 医学部, 教授
1986: Institute for Enzyme Research Tokushima University, 酵素科学センター, 教授
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Review Section/Research Field
Principal Investigator
Pathological medical chemistry
/
General medical chemistry
Except Principal Investigator
医学一般
/
Pathological medical chemistry
/
Biological pharmacy
/
General medical chemistry
/
Legal medicine
Keywords
Principal Investigator
肝細胞 / 増殖因子 / プロテアソ-ム / 初代培養 / 増殖抑制因子 / プロテアソーム / ユビキチン / 細胞接触 / 細胞周期 / 肝再生
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/ 初代培養肝細胞 / 細胞膜調節因子 / 分化 / インターロイキン / 多機能プロテア-ゼ複合体 / 多機能プロテアーゼ / がん細胞 / 細胞増殖 / 異常発現 / 白血病細胞 / 蛋白復合体 / ステロイドホルモン / グルカゴン / インスリン / サイクリックAMP / 活性型ビタミンD / 遺伝子発現 / 糖新生 / 高脂血症 / 増殖制御因子 / 発現ベクタ- / 細胞工学 / ヒト単球 / マイクロインジェクション / 卵母細胞 / 肝細胞の初代培養 / ツメガエル卵の発現系 / 遺伝子操作 / 生物工学 / 蛋白分解酵素 / 癌胎児性蛋白 / 遺伝子破壊 / ホルモン / 遺伝子 / 調節領域 / 転写因子 / クロマチン / 肝臓機能 / 肝細胞の増殖と分化 / 過形成腫粒 / 前癌状態 / 細胞増殖調節 / 血小板 / TGF-β / 肝癌細胞 / 多機能プロテア-ゼ / 多成分複合体 / 構造解析 / 高分子量プロテア-ゼ / 分子遺伝学 / 細胞内プロテア-ゼ / 20S環状粒子 / cDNAクロ-ニング / 発生と分化 / Proteasomes / Multicatalytic protease / Structural analysis / Multisubunit complex / High molecular weight protease / エネルギー依存性蛋白質分解 / 超分子複合体 / ガンマ型インターフェロン / 抗原プロセシング / MHCクラスエ拘束性抗原提示 / エネルギー依存性蛋白分解 / MHCクラスI拘束性抗原提示 / 多機能プロテアーゼ複合体 / 遺伝子転写制御機構 / 細胞内蛋白質分解機構 / 抗原プロセシング・提示 / 分子適合 / エネルギー依存性分子識別 / 蛋白質超分子複合体 / エネルギ-依存性分子識別 / 細胞増殖・分化 / Proteasome / Ubiquitin / Energy-dependent proteolysis / Cell cycle / Antigen Processing / Supramolecular complex / Gamma-interferon / MHC classI-restricted antigen presentation / Transforming growth factor(TGF)-β / Interleukin-1β / CAMP / ホルボル・エステル(TPA) / Transfoming Growth Factor(TGF-beta) / Interleukin(IL-1) / cyclic AMP / ホルボ-ルエステル / 増殖 / 細胞間相互作用 / DNA合成 / 細胞膜 / 混合培養 / 肝組織 / 肝細胞培養 / 増殖と機能 / 細胞増殖因子 / 細胞分化 / 組織構築 / Hepatocytes / Growth factors / Primary culture / Cell contact / Transforming growth factor(TGF)-beta / Interleukin-1beta / cAMP / Phorbol ester(TPA)
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More
Except Principal Investigator
細胞膜 / 細胞核 / 遺伝子操作 / 細胞操作 / ペプチド合成 / 高物子物質注入 / 赤血球ゴースト法 / 筋原細胞の融合 / 蛙卵によるmRNAの選別 / リン脂質合成欠損変異 / プロテアーゼによる情報発現 / 筋組織特異的94Kカルパイン / スロンボモジュリンの発現調節 / 血球内凝固因子 / 脳梗塞巣活性化カルパイン / アミロイドジェニックプロテアーゼ / カテプシンの細胞内選別輸送 / カテプシンの抗原提示への関与 / 筋組織特異的94Kカルバイン / カテプシン-インバリアント鎖による抗原提示の調節 / 筋組織特異的カルパイン / プロガストリンの活性化 / 心筋梗塞巣活性化カルパイン / カテプシンBの抗原阻囎への関与 / トランスゴルジ膜結合性プロセシングプロテアーゼ / プロテア-ゼによる情報発現 / プレプロタキキニン遺伝子発現調節因子 / カルパインの活性化 / カルパインペプチドの白血球遊走活性 / T細胞エイズレセプタ- / 26Sプロテアソ-ム / ニュ-カッスル病ウイルス / Limited proteolysis / 94K calpain / Thrombomodulin / Hematocyte coagulation factor / Calpain activation due to inafarotion / Amyloidogenic protease / Intracellular protease transport / Antigen presentation / オルガネラ構成因子 / 薬物 / 受容体 / 細胞質 / トランスダクション / 遺伝子調節 / Gタンパク質 / Cキナーゼ / 細胞膜因子 / 脂質輸送 / ホルモン受容体 / 膜結合性Gキナ-ゼ / 細胞膜タンパク質 / m‐RNA構造 / organella constituents / drugs / receptors / cell membrane / cytoplasm / cell nucleus / transduction / gene regulation / G protein / ステロイド・ホルモン / ステロイド・ホルモン作用機構 / 遺伝子発現調節レセプター / ステロイドホルモンレセプター / Steroid Hormone Receptor / Glucocorticoid / Testosterone / Estrogen / Progesterone / 軟骨由来因子 / 軟骨由来抗腫瘍因子 / 線維芽細胞由来内皮細胞増殖因子 / エリスロポエチン様因子 / インスリン作用促進因子 / 血小板由来増殖阻害因子 / 腫瘍増殖促進因子 / Bリンパ球分化因子 / Cartilage-Derived Factor (CDF) / Cartilage-derived Anti-Tumor Factor (CATF) / Fibroblast-derived Endothelial Cell Growth Factor (f-ECGF) / Erythropoietin-like factor / Insulin-Stimulating Peptide (ISP) / Platelet-Derived Growth Inhibitor (PDGI) / Tumor Growth Stimulating Activity (TGSA) / 薬物応答 / 代謝制御 / オルガネラ / リソソ-ム / 小胞体 / 細胞質因子 / 代謝制御機構 / リソソーム / 情報伝達 / Cellular responses / Metabolic regulation / Organella / Cell membrane / Cell nucleus / Lysosomes / Endoplasmic reticulum / Cytoplasmic factors
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Research Projects
(
19
results)
Co-Researchers
(
49
People)
Project Start Year (Newest)
Project Start Year (Oldest)
Studies on structure and the biological functions of a large multi-molecular complex "the proteasome"
Principal Investigator
Principal Investigator
ICHIHARA Akira
Project Period (FY)
1991 – 1993
Research Category
Grant-in-Aid for Specially Promoted Research
Research Institution
Institute for Enzyme Research, The University of Tokushima
Roles of proteases in signal transduction and their disorders
Principal Investigator
SASAKI Makoto
Project Period (FY)
1991 – 1993
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
Pathological medical chemistry
Research Institution
Nagoys City Unversity Medcal School
Co-operative Responses of Organella Constituents to Drug stimulation
Principal Investigator
OHBA Yoshiki
Project Period (FY)
1991 – 1993
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
Biological pharmacy
Research Institution
Kanazawa University
プロテアソ-ム(巨大蛋白分解酵素復合体)の構造解析と癌化における発現異常の解明
Principal Investigator
Principal Investigator
市原 明
Project Period (FY)
1990
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokushima
ホルモンによる遺伝子発現調節および病態に関する研究
Principal Investigator
Principal Investigator
市原 明
Project Period (FY)
1990
Research Category
Grant-in-Aid for Co-operative Research (B)
Research Field
Pathological medical chemistry
Research Institution
The University of Tokushima
培養肝細胞を用いた機能と増殖を調節する肝組織構築の生化学的研究
Principal Investigator
Principal Investigator
市原 明
Project Period (FY)
1990 – 1992
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Pathological medical chemistry
Research Institution
The University of Tokushima
多機能プロテアーゼ復合体(プロテアソーム)の機能と癌化における異常発現機構の解析
Principal Investigator
Principal Investigator
市原 明
Project Period (FY)
1989
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokushima
ホルモンによる遺伝子発現調節および病態に関する研究
Principal Investigator
Principal Investigator
市原 明
Project Period (FY)
1989
Research Category
Grant-in-Aid for Co-operative Research (B)
Research Field
Pathological medical chemistry
Research Institution
The University of Tokushima
肝細胞増殖制御因子の生物工学的技法による同定,遺伝子構造解析と大量生産のシステム化
Principal Investigator
Principal Investigator
市原 明
Project Period (FY)
1989 – 1991
Research Category
Grant-in-Aid for Developmental Scientific Research (B)
Research Field
General medical chemistry
Research Institution
The University of Tokushima
Structure and Cell Biology of a Novel Multicatalytic Proteinase Complex
Principal Investigator
Principal Investigator
ICHIHARA Akira
Project Period (FY)
1989 – 1990
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
General medical chemistry
Research Institution
The University of Tokushima
培養肝細胞を用いた増殖と分化の制御機構の研究
Principal Investigator
Principal Investigator
市原 明
Project Period (FY)
1988
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokushima
Analysis of Functional Cooperations between Organella in Responses to Medicines
Principal Investigator
ISHIBASHI Sadahiko.
Project Period (FY)
1988 – 1990
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
Legal medicine
Research Institution
Hiroshima University
培養肝細胞を用いた増殖と分化の制御機構の研究
Principal Investigator
Principal Investigator
市原 明
Project Period (FY)
1987
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokushima
細胞工学的手法によるヒトを含む高等動物細胞の体細胞遺伝生理学的研究
Principal Investigator
岡田 善雄
Project Period (FY)
1987
Research Category
Grant-in-Aid for Co-operative Research (B)
Research Field
医学一般
Research Institution
Osaka University
培養肝細胞を用いた増殖と分化の制御機構の研究
Principal Investigator
Principal Investigator
市原 明
Project Period (FY)
1986
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokushima
細胞工学的手法によるヒトを含む高等動物細胞の遺伝生理学的研究
Principal Investigator
岡田 善雄
Project Period (FY)
1986
Research Category
Grant-in-Aid for Co-operative Research (B)
Research Field
医学一般
Research Institution
Osaka University
Biochemical studies on tissue architecture of liver, which controls functions and growth, using primary cultured hepatocytes
Principal Investigator
Principal Investigator
ICHIHARA Akira
Project Period (FY)
1986 – 1989
Research Category
Grant-in-Aid for General Scientific Research (A)
Research Field
Pathological medical chemistry
Research Institution
University of Tokushima
Molecular Mechanism of Steroid Hormone Action and Modulation of Gene Expression
Principal Investigator
SAKAMOTO Yukiya
Project Period (FY)
1984 – 1986
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
General medical chemistry
Research Institution
Osaka University
Reaction mechanisms of various growth regulators and differentiation regulators and their clinical applications
Principal Investigator
SUZUKI Fujio
Project Period (FY)
1984 – 1986
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
Pathological medical chemistry
Research Institution
Osaka University
# of Projects (Dsc)
# of Projects (Asc)
1.
TANAKA Keiji
(10108871)
# of Collaborated Projects:
10 results
# of Collaborated Products:
0 results
2.
TOMITA Yumiko
(00089913)
# of Collaborated Projects:
8 results
# of Collaborated Products:
0 results
3.
NODA Chiseko
(40035506)
# of Collaborated Projects:
8 results
# of Collaborated Products:
0 results
4.
OHBA Yoshiki
(10012634)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
5.
中村 敏一
(00049397)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
6.
ISHIBASHI Sadahiko
(90012616)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
7.
NATORI Shunji
(50012662)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
8.
谷口 維紹
(50133616)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
9.
SASAKI Makoto
(10080003)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
10.
ICHIKAWA Atsushi
(10025695)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
11.
NOMURA Yasuyuki
(00034041)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
12.
森 正敬
(40009650)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
13.
市山 新
(90025601)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
14.
岡田 善雄
(30029756)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
15.
田代 裕
(40077558)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
16.
内田 驍
(40029781)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
17.
松原 謙一
(20037394)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
18.
新垣 理恵子
(00193061)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
19.
YOKOSAWA Hideyoshi
(90012765)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
20.
ISHIURA Shoichi
(10158743)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
21.
IKAI Atsushi
(50011713)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
22.
YOSHIMURA Tetsuro
(30035472)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
23.
OHKUBO Iwao
(80152073)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
24.
IWANAGA Sadaaki
(90029942)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
25.
SUZUKI Koichi
(80011948)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
26.
KATUNUMA Nobuhiko
(50035375)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
27.
OKAMOTO Hiroshi
(60025632)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
28.
SAKAMOTO Yukiya
(60028280)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
29.
ENDO Hiroyoshi
(50012604)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
30.
OTA Minoru
(70048255)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
31.
ICHII Shogo
(80032150)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
32.
SUZUKI Fujio
(40028717)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
33.
KISHIMOTO Tadamitsu
(10093402)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
34.
TAKEDA Yoshiro
(00028705)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
35.
TAKAKU Fumimaro
(40048955)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
36.
KATO Keitaro
(70037571)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
37.
尾形 悦郎
(70013761)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
38.
田中 武彦
(60028272)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
39.
藤井 義明
(00098146)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
40.
井村 裕夫
(10025570)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
41.
黒木 登志夫
(90006073)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
42.
石川 勝利
(00008608)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
43.
村地 孝
(10089104)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
44.
高橋 健治
(70011533)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
45.
木南 英紀
(10035496)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
46.
村山 昭
(10109952)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
47.
佐藤 威
(80125567)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
48.
赤松 穣
(00072900)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
49.
YAMANE Isao
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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