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SASAKI Makoto
佐々木 實
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Researcher Number
10080003
Other IDs
Affiliation (based on the past Project Information)
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2001: Nagoya City University Medical School Professor, 医学部, 教授
1995 – 1999: 名古屋市立大学, 医学部, 教授
1986 – 1993: 名古屋市立大学, 医学部, 教授
1986: Nagoya City University Medical School, 医学部, 教授
Review Section/Research Field
Principal Investigator
Pathological medical chemistry
/
Neuroscience in general
/
代謝生物化学
Except Principal Investigator
Structural biochemistry
/
代謝生物化学
/
General medical chemistry
/
物質生物化学
/
Pathological medical chemistry
Keywords
Principal Investigator
カルパイン / Calpain / NF-κB / NF-κBの活性化 / カルパインインヒビター / 虚血 / 抗カルパイン抗体 / 神経細胞死 / 脳神経細胞死 / Ischemia
…
More
/ Calpain inhibitor / IκB / IκB切断部位 / GST-IκB / カルパインインヒビターI / Lactacystin / IκBα / IκBα切断部位 / リコンビナント蛋白質 / basulovirus / 昆虫細胞Sf9 / プロテアーゼによる情報発現 / 筋組織特異的94Kカルパイン / スロンボモジュリンの発現調節 / 血球内凝固因子 / 脳梗塞巣活性化カルパイン / アミロイドジェニックプロテアーゼ / カテプシンの細胞内選別輸送 / カテプシンの抗原提示への関与 / 筋組織特異的94Kカルバイン / カテプシン-インバリアント鎖による抗原提示の調節 / 筋組織特異的カルパイン / プロガストリンの活性化 / 心筋梗塞巣活性化カルパイン / カテプシンBの抗原阻囎への関与 / トランスゴルジ膜結合性プロセシングプロテアーゼ / プロテア-ゼによる情報発現 / プレプロタキキニン遺伝子発現調節因子 / カルパインの活性化 / カルパインペプチドの白血球遊走活性 / T細胞エイズレセプタ- / 26Sプロテアソ-ム / ニュ-カッスル病ウイルス / Limited proteolysis / 94K calpain / Thrombomodulin / Hematocyte coagulation factor / Calpain activation due to inafarotion / Amyloidogenic protease / Intracellular protease transport / Antigen presentation / 再潅流 / カルパイン阻害剤 / 心筋梗塞 / 虚血再灌流 / μ-カルパイン前駆体 / 神経芽細胞腫 / 心筋虚血再灌流 / NFχB / Reperfusion / Miocardial infarction / NF-kappaB / Anti-calpain antibody / Neuronal cell death / 低酸素 / アポトーシス / ネクローシス / カルシウムinflux / カルシウム拮抗剤 / 虚血低酸素 / acridine orange / ethidium bromide法 / 脳虚血 / カルパスタチン / Hypoxia / Neuronal death / Apoptosis / Necrosis / Calcium infulx / Calciium chelate compound / プロテオリシス / プレプロエンザイムの活性化 / シグナルペプチダーゼ / プロティナーゼインヒビター / キニノーゲン / カテプシン / プロティナーゼの活性制御 / Proteolysis / Proteinase inhibitor / Kininogen / Calpastatin / Cathepsin / Signal peptidase / 炎症 / 走化性因子 / アセチル化ペプチド / ロイコエグレッシン / 免疫グロブリン / Inflammation / Chemotactic factor
…
More
Except Principal Investigator
プロテアーゼインヒビター / プロテアーゼ / プロセシング / プロテアソ-ム / 蛋白質分解 / プロテアソーム / LMP7 / MHC / 進化 / 細胞内プロテアーゼ / 内在性インヒビター / リソゾームプロテアーゼ / Ca依存性プロテアーゼ / 細胞増殖 / 癌 / 炎症 / 蛋白質分解に関する国際委員会 / 多機能プロテア-ゼ / 多成分複合体 / 構造解析 / 高分子量プロテア-ゼ / 分子遺伝学 / 多機能プロテア-ゼ複合体 / 細胞内プロテア-ゼ / 20S環状粒子 / cDNAクロ-ニング / 発生と分化 / Proteasomes / Multicatalytic protease / Structural analysis / Multisubunit complex / High molecular weight protease / キニン / カリクレイン / キニノーゲン / チオールプロテアーゼ / ラットTキニノーゲン / トリキニン / XII因子 / モノクロナール抗体 / キニンリセプター / ラットΤ-キニノーゲン / Kinin / Plasma kallikrein / Kininogen / Thiol-protease / Protease inhibitor / Rat T-kininogen / Ornitho-kinin / カルパイン / プロテア-ゼ / カテプシン / 遺伝子発現 / アテプシン / 病態 / カルシウムプロテアーゼ / ATPプロテアーゼ / Protease / calpain / cathepsin / proteasome / gene expression
Less
Research Projects
(
13
results)
Co-Researchers
(
27
People)
Project Start Year (Newest)
Project Start Year (Oldest)
カルパインによるNF-κB転写活性調整の解析
Principal Investigator
Principal Investigator
佐々木 實
Project Period (FY)
1999
Research Category
Grant-in-Aid for Scientific Research on Priority Areas (A)
Research Institution
Nagoya City University
カルパインによるNF-κB転写活性調節の解析
Principal Investigator
Principal Investigator
佐々木 實
Project Period (FY)
1998
Research Category
Grant-in-Aid for Scientific Research on Priority Areas (A)
Research Institution
Nagoya City University
Selective neuronal death induced by activation of pro μ-calpain under the hypoxic conditions
Principal Investigator
Principal Investigator
SASAKI Makoto
Project Period (FY)
1997 – 1999
Research Category
Grant-in-Aid for Scientific Research (B).
Research Field
Neuroscience in general
Research Institution
Nagoya City University
プロテアソームの抗原提示に於ける役割の系統発生学的解析
Principal Investigator
野中 勝
Project Period (FY)
1996
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Nagoya City University
Studies on the tissue damage induced by activation of calpains under infarct/ischemia
Principal Investigator
Principal Investigator
SASAKI Makoto
Project Period (FY)
1995 – 1996
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Pathological medical chemistry
Research Institution
Nagoya City University
細胞内タンパク質の分解と生理的意義
Principal Investigator
SUZUKI Koichi
Project Period (FY)
1993
Research Category
Grant-in-Aid for Co-operative Research (B)
Research Field
Structural biochemistry
Research Institution
The University of Tokyo
Roles of proteases in signal transduction and their disorders
Principal Investigator
Principal Investigator
SASAKI Makoto
Project Period (FY)
1991 – 1993
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
Pathological medical chemistry
Research Institution
Nagoys City Unversity Medcal School
Structure and Cell Biology of a Novel Multicatalytic Proteinase Complex
Principal Investigator
ICHIHARA Akira
Project Period (FY)
1989 – 1990
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
General medical chemistry
Research Institution
The University of Tokushima
Regulation and Pathology of Gene Expression of Intracellular Proteases Science, Dept. Mol. Biol., Director
Principal Investigator
SUZUKI Koichi
Project Period (FY)
1988 – 1990
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
Pathological medical chemistry
Research Institution
Tokyo Metropolitan Institute of Medical Science
細胞内プチテアーゼと内在性インヒビターの生理的先割とその病態
Principal Investigator
勝沼 信彦
Project Period (FY)
1987
Research Category
Grant-in-Aid for Co-operative Research (B)
Research Field
代謝生物化学
Research Institution
The University of Tokushima
Roles of thiol proteases and kininogens in induction and regulation of inflammation
Principal Investigator
Principal Investigator
SASAKI Makoto
Project Period (FY)
1987 – 1988
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Pathological medical chemistry
Research Institution
Nagoya City University Medical School
Biological Significance of Plasma Kallikrein-kinin System
Principal Investigator
IWANAGA Sadaaki
Project Period (FY)
1986 – 1987
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
物質生物化学
Research Institution
Kyushu University
Biological significance of proteolysis and its regulation
Principal Investigator
Principal Investigator
SASAKI Makoto
Project Period (FY)
1985 – 1986
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
代謝生物化学
Research Institution
Nagoya City University Medical School
# of Projects (Dsc)
# of Projects (Asc)
1.
SUZUKI Koichi
(80011948)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
2.
KUNIMATSU Mitoshi
(70145746)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
3.
KATUNUMA Nobuhiko
(50035375)
# of Collaborated Projects:
4 results
# of Collaborated Products:
0 results
4.
MURACHI Takashi
(10089104)
# of Collaborated Projects:
4 results
# of Collaborated Products:
0 results
5.
木南 英紀
(10035496)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
6.
OZAKI Yasuhiko
(50254280)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
7.
TAKAHASHI Kenji
(70011533)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
8.
IWANAGA Sadaaki
(90029942)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
9.
SUGITA Hideo
(80009951)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
10.
ICHIHARA Akira
(40035374)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
11.
OHKUBO Iwao
(80152073)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
12.
TADA Toyohiro
(20106230)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
13.
ICHIHARA Akira
(20035405)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
14.
川島 誠一
(60008571)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
15.
鮫島 達也
(50082772)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
16.
野中 勝
(40115259)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
17.
YOKOSAWA Hideyoshi
(90012765)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
18.
ISHIURA Shoichi
(10158743)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
19.
IKAI Atsushi
(50011713)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
20.
TANAKA Keiji
(10108871)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
21.
石川 勝利
(00008608)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
22.
HAYAKAWA Tomihiro
(50172995)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
23.
NAGASAWA Shigeharu
(70029958)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
24.
SAKAMOTO Wataru
(30001952)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
25.
NAKANISHI Shigetada
(20089105)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
26.
KATORI Makoto
(50050365)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
27.
KATO Keitaro
(70037571)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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