HIRAYAMA Noriaki 平山令明

Researcher Number	70238393
Other IDs
Affiliation (based on the past Project Information) *help	2016 – 2021: 東海大学, 先進生命科学研究所, 教授 2016: 東海大学, 先進生命研究所, 教授 2015: 東海大学, 糖鎖科学研究所, 教授 2014: 東海大学, 医学部, 教授 2005 – 2012: 東海大学, 医学部, 教授 … More 2010: Tokai University 2002: Tokai Univ. Eng. Professor, 大学院・医学研究科, 教授 1998 – 2001: 東海大学, 開発工学部, 教授 1992 – 1995: 東海大学, 開発工学部, 教授 Less
Review Section/Research Field	Principal Investigator Bioinformatics/Life informatics / Biological Sciences / 結晶学 Except Principal Investigator 生物・生体工学 / Applied genomics / Ophthalmology / 応用微生物学・応用生物化学 / Kidney internal medicine / General surgery / Emergency medicine … More / Biological Sciences / Tumor therapeutics / Orthopaedic surgery / Medium-sized Section 50:Oncology and related fields / Basic Section 56020:Orthopedics-related Less
Keywords	Principal Investigator 分子認識 / ドッキング / 医薬分子 / タンパク質 / 分子力学 / in silico創薬 / HLA / ホモロジー・モデリング / QSAR / 糖-アミノ酸相互作用 … More / 分子力学計算 / 単結晶X線解析 / 結晶化 / 糖ーアミノ酸相互作用 / 自動結晶化法 / sugar-amino acid interactions / molecular mechanics / single crystal X-ray analysis / molecular recognition / crystallization … More Except Principal Investigator タンパク質工学 / 重金属 / メタロチオネイン / SH基高含有タンパク質 / 重金属結合タンパク質 / 遺伝子発現 / hypoxia / HIF / 再生医療 / HLA / 創薬 / 椎間板変性 / 椎間板 / インシリコ創薬 / 摂食障害 / マイクロサテライト / 相関解析 / ネットワーク解析 / GWAS / 感受性遺伝子 / 疾患モデルマウス / コンタクチン / シナプトタグミン / NETO / シナプトガミン / シンタキシン / 酵母ツーハイブリッド法 / ゲノムワイド相関解析(GWAS) / シナプス小胞 / 神経伝達物質 / エンドサイトーシス / アレルギー / コレステロール / 酵素活性部位 / コンピュータグラフィックス / 臨床検査用酵素 / 酵素の耐熱性 / 結晶構造解析 / 試験管内変異 / Cholesterol / Cholesterol oxidase / Thermostable enzyme / トリコデルマ・リーセイ / セロビオハイドロラーゼII / サーモモノスポーラ・フスカ / エンドグルカナーゼE2 / セルラーゼ / 三次構造 / 蛋白質工学 / エキソ型セルラーゼ / エンド型セルラーゼ / 構造活性相関 / エンドグルカナーゼ E2 / Trichoderma reesei / cellobiohydrolase II / Thermmonospora fusca / endoglucanase E2 / cellulase / tertiary structure / protein engineering / metallothionein / heavy metal binding protein / Cd / Zn / molecular design / DNA binding / Arsenic / 慢性虚血 / prolyl hydroxylase / 腎保護 / 脳保護 / 糖尿病性腎症 / hypoxia inducible factor / structure based drug design / angiogenesis / chronic hypoxia / prolyl hydroxy lase / renoprotection / brain protection / diabetic nephropathy / 培養皮膚 / PHD阻害剤 / 血管新生 / 低酸素応答 / ヒト皮膚由来細胞 / HIF-1α / IL-15 / In silico screening / 老化 / 免疫疲弊 / 敗血症 / 炎症 / ミメティクス / 免疫 / ＨＬＡ / ゲノム多様性 / 立体構造 / 疾患感受性 / 疾患抵抗性 / 移植 / 自己免疫疾患 / 進化 / 疾病感受性 / データベース / 疾病 / ゲノム / HLA立体構造 / 自己免疫病 / Notch / 血液腫瘍 / T-ALL / Lmo2 / 抗腫瘍薬 / LMO2 / 悪性腫瘍 / 急性リンパ球性白血病 / 髄核細胞 / 椎間板再生 / 腰痛 / 転写因子 / iPS技術 / iPS細胞 / 移植・再生医療 / 再生医学 / 同種細胞移植 / 凍結保存 / 整形外科学 / 脊椎脊髄病学 / iPS細胞技術 / MHC / がん抗原 / ワクチン / ペプチドワクチン / T細胞エピトープ / IL-17 Less

The investigation of the new small molecule inhibitors of IL-17A for intervertebral disc disease treatment by In Silico analysis
- Principal Investigator
  
  隅山香織
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Tokai University
Analysis of cancer antigens through novel HLA assay
- Principal Investigator
  
  Miyadera Hiroko
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  University of Tsukuba
The exploration of new drug for the treatment of Notch-active tumor cells.
- Principal Investigator
  
  ANDO Kiyoshi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor therapeutics
- Research Institution
  Tokai University
Intervertebral disc regeneration and transcriptional control of nucleus pulpous progenitor cells by in silico pharmacogenesis and iPS technology
- Principal Investigator
  
  SAKAI Daisuke
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokai University
Development of cultured skin which has tolerance in ischemia.
- Principal Investigator
  
  INOKUCHI Sadaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Tokai University
In silico screening of Interleukin-15 mimetics and application for a treatment of elderly septic patients
- Principal Investigator
  
  INOUE Shigeaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Tokai University
The search for HLA inhibitor using short ragweed allergy mouse model.
- Principal Investigator
  
  KAWAGOE Tatsukata
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Ophthalmology
- Research Institution
  Yokohama City University
ＨＬＡ分子を標的としたｉｎ　ｓｉｌｉｃｏ医薬分子探索Principal Investigator
- Principal Investigator
  
  平山令明
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokai University
Integrated redearch for HLA disease and evolution
- Principal Investigator
  
  SASAZUKI Takehiko
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Genome-wide identification of genes for anorexia and their cascade analysis on disease development by functional study
- Principal Investigator
  
  INOKO Hidetoshi
- Project Period (FY)
  2007 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Applied genomics
- Research Institution
  Tokai University
in silico analysis of molecular interactions between commercially available drugs in Japan and proteinsPrincipal Investigator
- Principal Investigator
  
  HIRAYAMA Noriaki
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioinformatics/Life informatics
- Research Institution
  Tokai University
Development of novel compounds that enhance HIF activity and ameliorate chronic hypoxia in diabetic nephropathy and other diseases.
- Principal Investigator
  
  MIYATA Toshio
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokai University
Structure and function of metal-binding human metallothionein
- Principal Investigator
  
  MUROOKA Yoshikatsu
- Project Period (FY)
  1999 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  生物・生体工学
- Research Institution
  Osaka University
Construction of cellobiohydrolase from filamentous fungus with endo-type cleavage fashion using protein engineering
- Principal Investigator
  
  MORIKAWA Yasushi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  Nagaoka University of Technology
重金属を選択的にターゲティングするタンパク質分子のデザイン
- Principal Investigator
  
  MUROOKA Yoshikatsu
- Project Period (FY)
  1994 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Osaka University
Development of stable cholesterol oxidase used for diagnosis
- Principal Investigator
  
  MUROOKA Yoshikatsu
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  生物・生体工学
- Research Institution
  Osaka University
  Hiroshima University
Studies on Molecular Recognition Patterns between Sugars and Amino Acids by Use of the Data Obtained from Single Crystal X-Ray AnalysisPrincipal Investigator
- Principal Investigator
  
  HIRAYAMA Noriaki
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  結晶学
- Research Institution
  Tokai University

All 2019 2013 2012 2011 2010 2009 2008 2007

All Journal Article Presentation Patent

[Journal Article] Effects of interleukin-17A in nucleus pulposus cells and its small-molecule inhibitors for intervertebral disc disease2019
- Author(s)
  Kaori Suyama, Daisuke Sakai, Noriaki Hirayama, Yoshihiko Nakamura, Erika Matsushita, Hayato Terayama, Ning Qu, Osamu Tanaka, Kou Sakabe, Masahiko Watanabe
- Journal Title
  
  J Cell Mol Med
  
  Volume: Nov;22 Pages: 5539-5551
- DOI
  10.1111/jcmm.13828
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10946, KAKENHI-PROJECT-18K10031, KAKENHI-PROJECT-16H05456
[Journal Article] Establishment of HLA-DR4 Transgenic Mice for the Identification of CD4+ T Cell Epitopes of Tumor-Associated Antigens2013
- Author(s)
  Yatsuda J, Irie A, Harada K, Michibata Y, Tsukamoto H, Senju S, Tomita Y, Yuno A, Hirayama M, Abu Sayem M, Takeda N, Shibuya I, Sogo S, Fujiki F, Sugiyama H, Eto M, Nishimura Y.
- Journal Title
  
  PLos One
  
  Volume: 8
- DOI
  10.1371/journal.pone.0084908
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22133001, KAKENHI-PLANNED-22133005, KAKENHI-PROJECT-23510243, KAKENHI-PROJECT-24700991, KAKENHI-PROJECT-24700994
[Journal Article] A novel target-based de novo ligand design by use of pseudomolecular probe2010
- Author(s)
  K.Toda, J.Goto, N.Hirayama
- Journal Title
  
  Med.Chem.Comm
  
  Volume: 1 Pages: 349-354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19200024
[Journal Article] Alpha Sphere Filter Method : Application of Pseudomolecular Descriptors in Virtual Screening of 2D Chemical Structures2010
- Author(s)
  H.Muta, N.Hirayama
- Journal Title
  
  J.Comput.Chem. 31
  
  Pages: 2225-2232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19200024
[Journal Article] Alpha Sphere Filter Method : Application of Pseudomolecular Descriptors in Virtual Screening of 2D Chemical Structures2010
- Author(s)
  M. Muta, N. Hirayama
- Journal Title
  
  J.Comput.Chem. 31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19200024
[Journal Article] Use of amino acid composition to predict epitope residues of individual antibodies2010
- Author(s)
  S. Soga, D. Kuroda, H. Shirai, M. Kobori, N. Hirayama
- Journal Title
  
  Protein Eng.Des.Sel. 23
  
  Pages: 441-448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19200024
[Journal Article] A noveltarget-based de novo ligand designby use of pseudomolecular probe2010
- Author(s)
  K.Toda, J.Goto, N.Hirayama
- Journal Title
  
  Med.Chem.Comm. 1
  
  Pages: 349-354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19200024
[Journal Article] Alpha Sphere Filter Method : Application of Pseudomolecular Descriptors in Virtual Screening of 2D Chemical Structures2010
- Author(s)
  H.Muta, N.Hirayama
- Journal Title
  
  J.Comput.Chem
  
  Volume: 31 Pages: 2225-2232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19200024
[Journal Article] 擬似分子プローブと標的分子構造に基づくde novo医薬分子設計法の開発2009
- Author(s)
  東田欣也、後藤純一、平山令明
- Journal Title
  
  SAR News 16
  
  Pages: 16-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19200024
[Journal Article] Use of Amino Acid Composition to Predict Ligand-Binding Sites2008
- Author(s)
  N. Hirayama, S. Soga, H. Shirai, M. Kobori
- Journal Title
  
  Drugs of the Future 33A
  
  Pages: 76-76
- NAID
  130004574950
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19200024
[Journal Article] ASEDock-Docking Based on Alpha Spheres and Excluded Volumes2008
- Author(s)
  J.Goto, R.Kataoka, H.Muta and N.Hirayama
- Journal Title
  
  J.Chem.Inf.Model. 48(印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19200024
[Journal Article] Chemocavity : specific concavity in protein reserved for the binding of biologically functional small molecules2008
- Author(s)
  S.Soga, H.Shirai, M.Kobori, N.Hirayama
- Journal Title
  
  J.Chem.Inf. Model. 48
  
  Pages: 1679-1685
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19200024
[Journal Article] Chemocavity : specific concavity in protein reserved for the binding of biologically functional small molecules2008
- Author(s)
  S. Soga, H. Shirai, M. Kobori, N. Hirayama
- Journal Title
  
  J. Chem. Inf. Model 48
  
  Pages: 1679-1685
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19200024
[Journal Article] Use of Amino Acid Composition to Predict Ligand?Binding Sites2008
- Author(s)
  N.Hirayama, S.Soga,H.Shirai, M.Kobori
- Journal Title
  
  Drugs of the Future 33A
  
  Pages: 76-76
- NAID
  130004574950
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19200024
[Journal Article] ASEDock-Docking Based on Alpha Spheres and Excluded Volumes2008
- Author(s)
  J.Goto, R.Kataoka, H.Muta, N.Hirayama
- Journal Title
  
  J.Chem.Inf.Model. 48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19200024
[Journal Article] Use of Amino Acid Composition to Predict Ligand-Binding Sites2007
- Author(s)
  S.Soga, H.Shirai, M.Kobori and N.Hirayama
- Journal Title
  
  J.Chem.Inf.Model. 47
  
  Pages: 400-406
- NAID
  130004574950
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19200024
[Journal Article] Use of Amino Acid Composition to Predict Ligand-Binding Sites2007
- Author(s)
  S.Soga, H.Shirai, M.Kobori, N.Hirayama
- Journal Title
  
  J.Chem.Inf. Model. 47
  
  Pages: 400-406
- NAID
  130004574950
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19200024
[Journal Article] Identification of the druggable concavity in homology models using the PLB index2007
- Author(s)
  S.Soga, H.Shirai, M.Kobori, N.Hirayama
- Journal Title
  
  J.Chem.Inf.Model. 47
  
  Pages: 2287-2292
- NAID
  130004574951
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19200024
[Journal Article] Identification of the druggable concavity in homology models using the PLB index2007
- Author(s)
  S.Soga, H.Shirai, M.Kobori and N.Hirayama
- Journal Title
  
  J.Chem.Inf.Model. 47
  
  Pages: 2287-2292
- NAID
  130004574951
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19200024
[Patent] IL-17受容体結合部の阻害によるIL-17活性の制御方法2019
- Inventor(s)
  酒井大輔、隅山香織、平山令明
- Industrial Property Rights Holder
  学校法人東海大学、日本臓器製薬株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-030061
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-16H05456
[Presentation] In Silico創薬による新規低分子IL-17A阻害剤を用いた椎間板変性治療の可能性2019
- Author(s)
  隅山香織、酒井大輔、平山令明、坂部貢、渡辺雅彦
- Organizer
  第34回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16H05456
[Presentation] 新規低分子IL-17A阻害剤による椎間板変性治療法の可能性を評価する2019
- Author(s)
  隅山香織、酒井大輔、平山令明、坂部貢、渡辺雅彦
- Organizer
  第48回日本脊椎脊髄病学会
- Data Source
  KAKENHI-PROJECT-16H05456
[Presentation] HLABAP: HLA結合性ペプチドの結合予測システム2013
- Author(s)
  平山令明
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2013-03-30
- Data Source
  KAKENHI-PLANNED-22133012
[Presentation] HLA-A*31:01が関与するカルバマゼピンの副作用発現の分子機構2013
- Author(s)
  平山令明
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2013-03-30
- Data Source
  KAKENHI-PLANNED-22133012
[Presentation] HLA-Modeler: HLA分子自動モデリングシステムの開発2013
- Author(s)
  平山令明
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2013-03-30
- Data Source
  KAKENHI-PLANNED-22133012
[Presentation] HLA-B*14:02を介したネビラピンの副作用発現の分子機構2013
- Author(s)
  平山令明
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2013-03-30
- Data Source
  KAKENHI-PLANNED-22133012
[Presentation] ビリルビンによる自己免疫疾患制御の可能性2012
- Author(s)
  磯貝秀人、平山令明
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PLANNED-22133012
[Presentation] HLAの機能を制御できる低分子化合物のin silico探索・創製の試み2011
- Author(s)
  平山令明
- Organizer
  第20回日本組織適合性学会大会
- Place of Presentation
  ツインメッセ静岡(招待講演)
- Year and Date
  2011-08-30
- Data Source
  KAKENHI-PLANNED-22133012
[Presentation] Prediction of the binding mode between HLA-DP5 and an immunodominant peptide derived from the major Japanese cedar pollen allergens2011
- Author(s)
  M.Oikawa, H.Isogai, N.Hirayama
- Organizer
  The 2011 Joint Conference of CBI & JSBi
- Place of Presentation
  神戸国際会議場
- Year and Date
  2011-11-08
- Data Source
  KAKENHI-PLANNED-22133012
[Presentation] in silico創薬科学は稀少疾患治療薬の研究開発を可能にするか?2010
- Author(s)
  平山令明
- Organizer
  CBI学会2010年大会
- Place of Presentation
  学術総合センター(東京)
- Year and Date
  2010-09-15
- Data Source
  KAKENHI-PROJECT-19200024
[Presentation] アミノ酸組成を利用した医薬分子結合部位の予測2010
- Author(s)
  曽我真司、白井宏樹、小堀正人、平山令明
- Organizer
  CBI学会2010年大会
- Place of Presentation
  学術総合センター(東京)
- Year and Date
  2010-09-16
- Data Source
  KAKENHI-PROJECT-19200024
[Presentation] コンピュータを用いた合理的創薬法の現状とその可能性2010
- Author(s)
  平山令明
- Organizer
  第25回日本整形外科学会基礎学術集会
- Place of Presentation
  国立京都国際会館(京都)
- Year and Date
  2010-10-15
- Data Source
  KAKENHI-PROJECT-19200024
[Presentation] Chemocavity : Specific Concavity in Protein Reserved for the Binding of Biologically Functional Small Molecules2009
- Author(s)
  S.Soga, H.Shirai, M.Kobori, N.Hirayama
- Organizer
  17th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB) and 8th European Conference on Computational Biology (ECCB)
- Place of Presentation
  ストックホルム、スウェーデン
- Year and Date
  2009-07-01
- Data Source
  KAKENHI-PROJECT-19200024
[Presentation] PLB法を用いた低分子結合部位の差別化2009
- Author(s)
  平山令明
- Organizer
  第10回日本バイオインフォマティクス学会創薬インフォマティクス研究会
- Place of Presentation
  産総研臨海副都心センター (東京)
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-19200024
[Presentation] PLB法を用いた低分子結合部位の差別化2009
- Author(s)
  平山令明
- Organizer
  第10回日本バイオインフォマティクス学会創薬インフォマティクス研究会
- Place of Presentation
  産総研臨海副都心センター(東京)
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-19200024
[Presentation] Chemocavity : Specific Concavity in Protein Reserved for the Binding of Biologically Functional Small Molecules2009
- Author(s)
  S.Soga, H.Shirai, M.Kobori, N.Hirayama
- Organizer
  17th Annual International Conference on Intelligent Systems for Molecular Biologv (ISMB) and 8th European Conference on Computational Biology (ECCB)
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2009-07-01
- Data Source
  KAKENHI-PROJECT-19200024
[Presentation] AutoGPA モデルによる受容体ポケットの特徴抽出2009
- Author(s)
  朝川直行、小林誠一、後藤純一、平山令明
- Organizer
  第37回構造活性相関シンポジウム
- Place of Presentation
  北里大学薬学部(東京)
- Year and Date
  2009-11-12
- Data Source
  KAKENHI-PROJECT-19200024
[Presentation] AutoGPAモデルによる受容体ポケットの特徴抽出2009
- Author(s)
  朝川直行、小林誠一、後藤純一、平山令明
- Organizer
  第37回構造活性相関シンポジウム
- Place of Presentation
  北里大学薬学部(東京)
- Year and Date
  2009-11-12
- Data Source
  KAKENHI-PROJECT-19200024
[Presentation] AutoGPA:グリッドとファーマコフォアモデルの連携による3D-QSARモデルの自動構築2009
- Author(s)
  朝川直行、小林誠一、後藤純一、平山令明
- Organizer
  第37回構造活性相関シンポジウム
- Place of Presentation
  北里大学薬学部(東京)
- Year and Date
  2009-11-13
- Data Source
  KAKENHI-PROJECT-19200024
[Presentation] PLB法を用いた低分子結合部位の差別化2009
- Author(s)
  平山令明
- Organizer
  第10回日本バイオインフォマティクス学会
- Place of Presentation
  木産業技術総合研究所 (東京)
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-19200024
[Presentation] Chemocavity : Specific concavity in protein reserved for the binding of biologically functional small molecules2009
- Author(s)
  S. Soga, H. Shirai, M. Kobori, N. Hirayama
- Organizer
  17th Annual International Conference on Intelligent Systems for Molecular Biology
- Place of Presentation
  ストックホルム (スウェーデン)
- Year and Date
  2009-07-01
- Data Source
  KAKENHI-PROJECT-19200024
[Presentation] 疑似分子プローブと標的構造に基づくde novo医薬分子設計法の開発2008
- Author(s)
  東田欣也, 後藤純一, 平山令明
- Organizer
  第36回構造活性相関シンポジウム
- Place of Presentation
  神戸国際会議場(神戸)
- Year and Date
  2008-11-02
- Data Source
  KAKENHI-PROJECT-19200024
[Presentation] Use of Amino Acid Composition to Predict Ligand-Bindine Sites2008
- Author(s)
  平山令明
- Organizer
  XXth International Symposium on Medicinal Chemistry
- Place of Presentation
  ウイーン(オーストリア)
- Year and Date
  2008-09-04
- Data Source
  KAKENHI-PROJECT-19200024
[Presentation] Use of Amino Acid Composition to Predict Ligand-Binding Sites2008
- Author(s)
  平山令明
- Organizer
  XXth International Symposium on Medicinal Chemistry
- Place of Presentation
  ウイーン(オーストリア)
- Year and Date
  2008-09-04
- Data Source
  KAKENHI-PROJECT-19200024
[Presentation] アミノ酸の共起性から見た蛋白質の低分子化合物結合部位2008
- Author(s)
  曽我真司,白井宏樹,小堀正人,平山令明
- Organizer
  第36回構造活性相関シンポジウム
- Place of Presentation
  神戸国際会議場(神戸)
- Year and Date
  2008-11-03
- Data Source
  KAKENHI-PROJECT-19200024
[Presentation] アミノ酸の共起性から見た蛋白質の低分子化合物結合部位2008
- Author(s)
  曽我真司,白井宏樹,小堀正人,平山令明
- Organizer
  第8回日本蛋白質科学会年会
- Place of Presentation
  タワーホール船堀(東京)
- Year and Date
  2008-06-10
- Data Source
  KAKENHI-PROJECT-19200024
[Presentation] アミノ酸組成を利用した医薬分子結合部位の予測2007
- Author(s)
  曽我真司, 白井宏樹, 小堀正人, 平山令明
- Organizer
  第30回情報化学討論会
- Place of Presentation
  京都大学
- Year and Date
  2007-11-16
- Data Source
  KAKENHI-PROJECT-19200024
[Presentation] In silico screening: from nice-to-use to must-use technology for drug discovery2007
- Author(s)
  平山令明
- Organizer
  情報計算化学生物学会 2007年大会
- Place of Presentation
  広島大学
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-19200024
[Presentation] PLBを利用した蛋白質モデル構造における医薬分子結合部位の予測2007
- Author(s)
  曽我真司, 白井宏樹, 小堀正人, 平山令明
- Organizer
  第30回情報化学討論会
- Place of Presentation
  京都大学
- Year and Date
  2007-11-16
- Data Source
  KAKENHI-PROJECT-19200024

1. MUROOKA Yoshikatsu (60029882)

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2. INOKO Hidetoshi (10101932)

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23. INOUE Shigeaki (30582209)

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24. SASAZUKI Takehiko (50014121)

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38. 檜山明彦 (00514382)

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49. 坂部貢

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50. 曲寧

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HIRAYAMA Noriaki 平山 令明

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ＨＬＡ分子を標的としたｉｎ ｓｉｌｉｃｏ医薬分子探索Principal Investigator

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in silico analysis of molecular interactions between commercially available drugs in Japan and proteinsPrincipal Investigator

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HIRAYAMA Noriaki 平山令明

ＨＬＡ分子を標的としたｉｎ　ｓｉｌｉｃｏ医薬分子探索Principal Investigator