HOZUMI Katsuto 穂積勝人

… Alternative Names

穂積勝人ホヅミカツト

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Researcher Number	30246079
Affiliation (Current)	2023: 東海大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2016 – 2021: 東海大学, 医学部, 教授 2015 – 2016: 東海大学, 医学部, 准教授 2007 – 2013: Tokai University, School of Medicine, Associate Professor 2005 – 2006: 東海大学, 医学部, 助教授 2001 – 2002: 東海大学, 医学部, 講師 1995 – 1998: 東海大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Biological Sciences / Immunology / Experimental pathology / Immunology / Basic Section 48040:Medical biochemistry-related Except Principal Investigator Gastroenterology / General medical chemistry / Immunology / Tumor therapeutics / Hematology / Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 54020:Connective tissue disease and allergy-related
Keywords	Principal Investigator T細胞 / Notch / 胸腺 / Notchリガンド / 分化 / GATA3 / TCR / 遺伝子再構成 / 膵臓 / Notchシグナル … More / パイエル板 / 骨髄 / 骨芽細胞 / Dll4 / Notch1 / CD3 / 脱メチル化 / T細胞レセプター / シスエレメント / 転写因子 / TCR遺伝子 / 転写制御 / 分化決定 / 胎仔胸腺器官培養 / IL-7 / Notch リガンド / NotchL / 細胞系譜 / Jaggedl / 初期発生 / Hes1 / Ngn3 / Ptf1a / 胸膜 / Jagged1 / 環境 / 増殖 / D114 / 発生病理 / 分化環境 / 膵臟 / Sox9 / 膵細胞 / 未分化性 / Cre/loxP / T cells / Notch ligand / 細胞外環境 / ILC2 / Notchシステム / Lmo2 / Bcl11a / Tcf1 / T細胞分化 / エピジェネティクス / Treg / Tfh / Tfh細胞 / Treg細胞 / Dll1 / 立体構造 / 結合様式 / シミュレーション … More Except Principal Investigator positive selection / Notch / TCR発現 / チロシンリン酸化 / 肝線維化 / DP胸腺細胞 / 再生医学 / 再生 / Notchシグナル / ZAP-70 / D111 / Jagged / 線維化 / MHC拘束性 TCR / MHC拘束性TCR / 骨と骨髄 / niche / 造血恒常性 / 骨代謝 / 骨芽細胞 / 造血代謝 / 造骨細胞 / 破骨細胞 / 幹前駆細胞 / Notch/Jagged-1シグナル / 肝線維症 / 肝再生 / Jagged-1 / 幹細胞 / 肝臓学 / コレセプター / positive slection / T細胞レセプター(TCR) / シグナル伝達 / TCRトランスジェニックマウス / CD4 / CD8 / TCR expression / tyrosine phosphorylation / coreceptor / トランジェニックマウス / Jagged1 / 外分泌 / 内分泌 / ノックアウトマウス / グルカゴン / トランスジェニックマウス / 外分泌細胞 / 内分泌細胞 / 膵 / Dll1 / Pdx-Cre / ER / 膵幹細胞 / リガンド / Noctch / Transgenicmouse / exocrine / endocrine / knockout mouse / Ptfla-Cre / 血液腫瘍 / T-ALL / Lmo2 / 抗腫瘍薬 / LMO2 / 悪性腫瘍 / 急性リンパ球性白血病 / 創薬 / クローン病 / 炎症性腸疾患 / 腸管線維化 / TGF-β / YB-1 / 肝前駆細胞 / 発癌 / 内科 / 発がん / 細胞分化 / microRNA / 転写因子 / B細胞分化 / EBF1 / 細胞運命 / miRNA / 血液免疫学 / 小腸移植 / 虚血再潅流障害 / 免疫応答 / 虚血再灌流障害 / Delta-like 4 / メモリーCD４T細胞 / 短腸症候群 / 抗MDA5抗体 / 皮膚筋炎 / 急速進行性間質性肺疾患 / 縦隔気腫 / 予後不良因子 / 免疫学 / 無筋症性皮膚筋炎 / 急速進行性間質性肺炎 Less

抗MDA5抗体陽性皮膚筋炎/急速進行性間質性肺炎の病態解明および新規治療法の開発
- Principal Investigator
  
  佐藤慎二
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Tokai University
The molecular analysis of the structural basis of Notch1/Dll4 interaction for drug discovery.Principal Investigator
- Principal Investigator
  
  穂積勝人
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Tokai University
Notch signaling in small bowel allograft rejection
- Principal Investigator
  
  Masaharu Mori
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Tokai University
Significance of Notch signaling for the regulation of T cell response to gut-derived antigen as neo-selfPrincipal Investigator
- Principal Investigator
  
  穂積勝人
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokai University
Identification of miRNA which rescues EBF1 deficiency indispensable for B cell lineage commitment
- Principal Investigator
  
  KOTANI Ai
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Tokai University
Molecular mechanisms for the maintenance of T cell differentiation potential and the determination of T cell fatePrincipal Investigator
- Principal Investigator
  
  HOZUMI Katsuto
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tokai University
The exploration of new drug for the treatment of Notch-active tumor cells.
- Principal Investigator
  
  ANDO Kiyoshi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor therapeutics
- Research Institution
  Tokai University
免疫四次元空間におけるNotchリガンドの役割解明Principal Investigator
- Principal Investigator
  
  穂積勝人
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokai University
Analysis of collagen producing cell and new therapeutic target of TGF-b signal in colorectal fibrosis
- Principal Investigator
  
  IMAI Jin
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokai University
Pathophysiological Interplay between Liver Fibrosis, Regeneration and Hepatocarcinogenesis from the Viewpoint of Stem/progenitor Cell Differentiation
- Principal Investigator
  
  INAGAKI Yutaka
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokai University
Pathophysiological correlation between fibrogenesis and regeneration in murine liver via Notch/Jagged-1 signal
- Principal Investigator
  
  MIKAMI KENICHIRO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hirosaki University
生体内T細胞環境要因としてのNotchリガンドの役割Principal Investigator
- Principal Investigator
  
  穂積勝人
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokai University
Regeneration of Fibrotic Liver through Modulation of Hepatic Stem Cell Niche and Differentiation of Bone Marrow Stem Cells
- Principal Investigator
  
  INAGAKI Yutaka
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokai University
Study for the determination of cell fates by NotchL as environment factorPrincipal Investigator
- Principal Investigator
  
  HOZUMI Katsuto
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokai University
分化環境要因としてのNotchリガンドの役割Principal Investigator
- Principal Investigator
  
  穂積勝人
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokai University
胸腺の存在をDll4でどこまで解くことができるのかPrincipal Investigator
- Principal Investigator
  
  穂積勝人
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokai University
Identification of molecular mechanisms that link bone remodeling and hematopoietic homeostasis
- Principal Investigator
  
  NAKAYAMA Yukari
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokai University
Analysis of the molecular mechanism for the determination of cell fate and the tissue organization with Notch signalingPrincipal Investigator
- Principal Investigator
  
  HOZUMI Katsuto
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokai University
分化環境要因としてのNotchリガンドの役割Principal Investigator
- Principal Investigator
  
  穂積勝人
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokai University
Investigative of diffentiation of pancreatic cells and application for treatments for chronic pancreatitis
- Principal Investigator
  
  MINE Tetsuya
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokai University
Pre-thymic Notch signaling is necessary for GATA3 function in the initiation of T cell development.Principal Investigator
- Principal Investigator
  
  HOZUMI Katsuto
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tokai University
T細胞分化決定における分子機構の解析Principal Investigator
- Principal Investigator
  
  穂積勝人
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Tokai University
T細胞分化過程におけるTCR遺伝子高次構造制御の分子機構Principal Investigator
- Principal Investigator
  
  穂積勝人
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Immunology
- Research Institution
  Tokai University
胸腺内分化過程におけるT細胞レセプターの遺伝子再構築を抑制する分子機構
- Principal Investigator
  
  垣生園子
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokai University
T細胞分化決定にともなうTCRβ遺伝子の転写と再構成の機構解明Principal Investigator
- Principal Investigator
  
  穂積勝人
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Immunology
- Research Institution
  Tokai University
胸腺内分化モデルの確立による自己認識T細胞クローンの選択機構の解析
- Principal Investigator
  
  HABU Sonoko
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokai University
T細胞初期分化における分子機構の解明Principal Investigator
- Principal Investigator
  
  穂積勝人
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Immunology
- Research Institution
  Tokai University
The molecular mechanism of TCR repertoire generation and coreceptor expression
- Principal Investigator
  
  HABU Sonoko
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Tokai University

All 2022 2021 2020 2018 2017 2016 2015 2011 2010 2009 2008 2007 2006

All Journal Article Presentation Book

[Book] 胸腺内T細胞分化におけるDll4/Notchシグナルの役割、臨床免疫・アレルギー科2011
- Author(s)
  穂積勝人
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-21390121
[Book] 胸腺分化環境要因としてのDelta-like 4の役割、臨床免疫・アレルギー科2009
- Author(s)
  穂積勝人
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-21390121
[Journal Article] Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium2022
- Author(s)
  Hirano KI, Hosokawa H, Yahata T, Ando K, Tanaka M, Imai J, Yazawa M, Ohtsuka M, Negishi N, Habu S, Sato T, Hozumi K.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 852427-852427
- DOI
  10.3389/fimmu.2022.852427
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17413, KAKENHI-PROJECT-19H03692, KAKENHI-PROJECT-20K07330
[Journal Article] Notch signaling supports the appearance of follicular helper T cells in the Peyer’s patches concomitantly with the reduction of regulatory T cells2021
- Author(s)
  Yazawa M, Hosokawa H, Koizumi M, Hirano KI, Imai J, Hozumi K.
- Journal Title
  
  International Immunology
  
  Volume: 33(9) Pages: 469-478
- DOI
  10.1093/intimm/dxab032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17413, KAKENHI-PROJECT-19H03692, KAKENHI-PROJECT-20K07330
[Journal Article] LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice2021
- Author(s)
  Hirano K., Hosokawa H., Koizumi M., Endo Y., Yahata T., and Hozumi K
- Journal Title
  
  eLife
  
  Volume: 10
- DOI
  10.7554/elife.68227
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21618, KAKENHI-PROJECT-19H03692, KAKENHI-PROJECT-20H03455, KAKENHI-PROJECT-21H02767, KAKENHI-PROJECT-20K07330
[Journal Article] Peripheral PDGFRa+gp38+ mesenchymal cells support the differentiation of fetal liver-derived ILC22018
- Author(s)
  Koga, S., Hozumi, K., Hirano, K.I., Yazawa, M., Terooatea, T., Minoda, A., Nagasawa, T., Koyasu, S., and Moro, K.
- Journal Title
  
  The Journal of Experimental Medicine
  
  Volume: 215 Pages: 1609-1626
- DOI
  10.1084/jem.20172310
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05643, KAKENHI-PUBLICLY-17H05802, KAKENHI-PROJECT-18H05286, KAKENHI-PROJECT-16H02631, KAKENHI-PROJECT-18H03998, KAKENHI-PROJECT-16K08848
[Journal Article] Identification of a novel alpha-fetoprotein-expressing cell population induced by the Jagged 1/Notch 2 signal in murine fibrotic liver.2017
- Author(s)
  Yasuhiro Nakano, Sachie Nakao, Hideaki Sumiyoshi, Kenichiro Mikami, Yuri Tanno, Minako Sueoka, Daigo Kasahara, Hiroshi Kimura, Tadashi Moro, Akihide Kamiya, Katsuto Hozumi, Yutaka Inagaki
- Journal Title
  
  Hepatology Communications
  
  Volume: 印刷中 Pages: 1-15
- DOI
  10.1002/hep4.1026
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293179, KAKENHI-PROJECT-15K15299, KAKENHI-PROJECT-15K10071, KAKENHI-PROJECT-26293178, KAKENHI-PROJECT-16K15434, KAKENHI-PROJECT-16K19369, KAKENHI-PROJECT-17H04166
[Journal Article] Identification of Domains for Efficient Notch Signaling Activity in Immobilized Notch Ligand Proteins.2017
- Author(s)
  Liu L, Wada H, Matsubara N, Hozumi K and Itoh M.
- Journal Title
  
  J Cell Biochem
  
  Volume: 118 Pages: 785-796
- DOI
  10.1002/jcb.25744
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01161, KAKENHI-PROJECT-25670020
[Journal Article] Jagged1-induced Notch activation contributes to the acquisition of bortezomib resistance in myeloma cells2017
- Author(s)
  Yukari Muguruma, Takashi Yahata, Takayuki Warita, Katsuyo Hozumi, Yoshihiko Nakamura, Rikio Suzuki, Mamoru Ito, Kiyoshi Ando
- Journal Title
  
  Blood Cancer J.
  
  Volume: 7 Pages: 1007-1012
- DOI
  10.1038/s41408-017-0001-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04287, KAKENHI-PROJECT-15H04301, KAKENHI-PROJECT-17H03572, KAKENHI-PROJECT-16K14635
[Journal Article] Jun Abe, Kiyoshi Higashi, Yutaka Inagaki, and Tetsuya Mine: Anti-fibrotic effects of a novel small compound on the regulation of cytokine production in a mouse model of colorectal fibrosis.2015
- Author(s)
  Imai J, Hozumi K, Sumiyoshi H, Yazawa M, Hirano K, Abe J, Higashi K, Inagaki Y, Mine T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 468 Pages: 554-560
- DOI
  10.1016/j.bbrc.2015.10.123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10071, KAKENHI-PROJECT-15K15299, KAKENHI-PROJECT-25293179
[Journal Article] Delta-like 4-mediated Notch signaling is required for early T cell development in a three-dimensional thymic structure2015
- Author(s)
  Hirano K, Negishi N, Yazawa M, Yagita H, Habu S, Hozumi K
- Journal Title
  
  European Journal of Immunology
  
  Volume: 45 Pages: 2252-2262
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01161
[Journal Article] Anti-fibrotic effects of a novel small compound on the regulation of cytokine production in a mouse model of colorectal fibrosis.2015
- Author(s)
  Imai J, Hozumi K, Sumiyoshi H, Yazawa M, Hirano K, Abe J, Higashi K, Inagaki Y, Mine T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 468(4) Pages: 554-560
- DOI
  10.1155/2016/2964581
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19353
[Journal Article] Notch ligands transduce different magnitudes of signaling critical for determination of T-cell fate2011
- Author(s)
  Abe N, Hozumi K, Hirano K, Yagita H and Habu S
- Journal Title
  
  Eur. J. Immunol
  
  Volume: 40 Pages: 2608-2617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390121
[Journal Article] Notch signaling is necessary for GATA3 function in the initiation of T cell development2008
- Author(s)
  Hozumi K., et.al.
- Journal Title
  
  European Journal of Immunology 38
  
  Pages: 977-985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20057026
[Journal Article] Expression of Delta-like 1 in the splenic non-hematopoietic cells is essential for marginal zone B cell development.2008
- Author(s)
  Sheng, Y., Yahata, T., Negishi, N., Nakano, Y., Habu, S., Hozumi, K. and Ando, K.
- Journal Title
  
  Immunol. Lett. 121
  
  Pages: 33-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390115
[Journal Article] Notch signaling is necessary for GATA3 function in the initiation of T cell development.2008
- Author(s)
  Hozumi K., et al.
- Journal Title
  
  European Journal of Immunology 38
  
  Pages: 977-985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390115
[Journal Article] Notch signaling is necessary for GATA3 function in the initiation of T cell development.2008
- Author(s)
  Hozumi, K., Negishi, N., Tsuchiya, I., Abe, N., Hirano, K., Suzuki, D., Yamamoto, M., Engel, J. D. and Habu, S.
- Journal Title
  
  Eur. J. Immunol. 38
  
  Pages: 977-985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390115
[Journal Article] Delta-like 4 is indispensable in thymic environment specific for T cell development.2008
- Author(s)
  Hozumi K., et al.
- Journal Title
  
  Journal of Experimental Medicine 205
  
  Pages: 2507-2513
- NAID
  40016715345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390115
[Journal Article] Delta-like 4 is indispensable in thymic environment spe cific for T cell development2008
- Author(s)
  Hozumi K., et.al.
- Journal Title
  
  Journal of Experimental Medicine 205
  
  Pages: 2507-2513
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20060024
[Journal Article] Delta-like 4 is indispensable in thymic environment specific for T cell development2008
- Author(s)
  Hozumi K., et.al.
- Journal Title
  
  Journal of Experimental Medicine 205
  
  Pages: 2507-2513
- NAID
  40016715345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20057026
[Journal Article] Notch signaling is necessary for GATA3 function in the initiation of T cell development2008
- Author(s)
  Hozumi K., et.al.
- Journal Title
  
  European Journal of Immunology 38
  
  Pages: 977-985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20060024
[Journal Article] Delta-like 4 is indispensable in thymic environment specific for T cell development.2008
- Author(s)
  Hozumi, K., Mailhos, C., Negishi, N., Hirano, K., Yahata, T., Ando, K., Zuklys, S., Hollander, G. A., Shima, D. T. and Habu, S.
- Journal Title
  
  J. Exp. Med. 205
  
  Pages: 2507-2513
- NAID
  40016715345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390115
[Journal Article] Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo.2007
- Author(s)
  Oyama, T., Harigaya, K., Muradil, A., Hozumi, K., Habu, S., Iwama, A., Oguro, H., Matsuno, K., Sakamoto, R., Sato, M., Yoshida, N. and Kitagawa, M.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA. 104
  
  Pages: 9764-9769
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390115
[Journal Article] Jaggedl is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis.2006
- Author(s)
  Estrach S, Ambler CA, Lo Celso C, Hozumi K, Watt FM
- Journal Title
  
  Development 133
  
  Pages: 4427-4438
- Data Source
  KAKENHI-PROJECT-18060040
[Journal Article] Notch ligands with contrasting functions : Jaggedi and Delral in the mouse inner ear.2006
- Author(s)
  Brooker R, Hozumi K, Lewis J
- Journal Title
  
  Development 133
  
  Pages: 1277-1286
- Data Source
  KAKENHI-PROJECT-18060040
[Presentation] Dll1 and Dll4 differently require their extracellular domains for triggering Notch signaling in mice2020
- Author(s)
  穂積勝人
- Organizer
  日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07330
[Presentation] The epigenetic regulation of gene loci encoding transcription factor critical for the determination of T/B-cell lineages by Lmo22018
- Author(s)
  Hozumi K, Hirano KI
- Organizer
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-16K08848
[Presentation] Molecular machinery for the maintenance of differentiation potential toward T/B cell lineages in hematopoietic stem/progenitor cells by Lmo22017
- Author(s)
  Katsuto Hozumi, Shuhei Ochiai, Ken-ichi Hirano
- Organizer
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-16K08848
[Presentation] Jagged1/Notchシグナルを介した線維肝再生における前駆細胞動員機構の解明．2017
- Author(s)
  中野泰博、中尾祥絵、住吉秀明、三上健一郎、丹野友里、末岡美那子、笠原大瑚、木村啓志、茂呂　忠、紙谷聡英、穂積勝人、稲垣　豊
- Organizer
  第16回日本再生医療学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-09
- Data Source
  KAKENHI-PROJECT-25293179
[Presentation] Molecular machinery for the maintenance of differentiation potential toward T/B cell lineages in hematopoietic stem/progenitor cells by Lmo22017
- Author(s)
  Hozumi K、Ochiai S、Hirano K
- Organizer
  日本免疫学会・学術集会
- Data Source
  KAKENHI-PROJECT-16K14635
[Presentation] Dll4-mediated Notch1 signaling is required for the conversion from Treg to Tfh in Peyers patch.2016
- Author(s)
  Yazawa M and Hozumi K
- Organizer
  日本免疫学会・学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PUBLICLY-15H01161
[Presentation] Essential role of Lmo2 for the maintenance of T-cell differentiation potential in Ebf1-deficient pro-B cells.2016
- Author(s)
  Hozumi K、Ochiai S、Hirano K
- Organizer
  日本免疫学会・学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K08848
[Presentation] Anti-fibrotic effects of a novel small compound that promotes the nuclear translocation of YB-1 in a mouse model of colorectal fibrosis.2016
- Author(s)
  Imai J, Hozumi K, Inagaki Y, Mine T.
- Organizer
  European Crohn's and Colitis Organisation 2016
- Place of Presentation
  ＲＡＩ Amsterdam (Netherlands)
- Year and Date
  2016-03-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19353
[Presentation] Contribution of Jagged1/Notch signaling to murine fibrotic liver regeneration through possible dedifferentiation of mature hepatocytes.2016
- Author(s)
  Yasuhiro Nakano, Sachie Nakao, Hideaki Sumiyoshi, Kenichiro Mikami, Yuri Tanno, Daigo Kasahara, Hiroshi Kimura, Tadashi Moro, Akihide Kamiya, Katsuto Hozumi, Yutaka Inagaki
- Organizer
  67th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Hynes Convention Center (Boston, MA, U.S.A.)
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293179
[Presentation] YB-1の核内移行を促進させる小化合物を用いたクローン病腸管線維化モデルに対する抗線維化治療の検討2016
- Author(s)
  今井　仁、峯　徹哉、稲垣　豊、穂積　勝人
- Organizer
  第102回に本消化器病学会総会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-15K19353
[Presentation] Essential role of Lmo2 for the maintenance of T-cell differentiation potential in Ebf1-deficient pro-B cells2016
- Author(s)
  Hozumi K、Ochiai S、Hirano K
- Organizer
  日本免疫学会・学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K14635
[Presentation] 肝発生および線維肝再生過程における肝前駆細胞は、間葉系細胞のJagged-1をリガンドとするNotchシグナルによって制御される．2016
- Author(s)
  中野泰博、中尾祥絵、住吉秀明、三上健一郎、丹野友里、茂呂　忠、紙谷聡英、穂積勝人、稲垣　豊
- Organizer
  第23回肝細胞研究会
- Place of Presentation
  大阪大学中之島センター（大阪府大阪市）
- Year and Date
  2016-07-07
- Data Source
  KAKENHI-PROJECT-25293179
[Presentation] Contribution of Jagged1/Notch signaling to murine fibrotic liver regeneration through possible dedifferentiation of mature hepatocytes.2016
- Author(s)
  Yasuhiro Nakano, Sachie Nakao, Hideaki Sumiyoshi, Kenichiro Mikami, Yuri Tanno, Minako Sueoka, Daigo Kasahara, Hiroshi Kimura, Tadashi Moro, Akihide Kamiya, Katsuto Hozumi, Yutaka Inagaki
- Organizer
  9th Notch Meeting
- Place of Presentation
  国立遺伝学研究所（静岡県三島市）
- Year and Date
  2016-10-05
- Data Source
  KAKENHI-PROJECT-25293179
[Presentation] Jagged1/Notchシグナルは線維肝再生における肝前駆細胞の動員に機能する．2016
- Author(s)
  中野泰博、中尾祥絵、住吉秀明、三上健一郎、丹野友里、末岡美那子、笠原大瑚、木村啓志、茂呂　忠、紙谷聡英、穂積勝人、稲垣　豊
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-25293179
[Presentation] The structure-function relationship in Dll1/Dll4 chimeric molecules for supporting T cell development2015
- Author(s)
  Hozumi K, Ochiai, S, Hirano K
- Organizer
  日本分子生物学会年会
- Place of Presentation
  兵庫県神戸市・神戸コンベンションセンター
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PUBLICLY-15H01161
[Presentation] Kaori Minakawa, Katsuto Hozumi, Isao Okazaki, Shinsaku Fukuda, Yutaka Inagaki. Notch/Jagged-1 signal modulates pathophysiological correlation between fibrogenesis and regeneration in murine liver2011
- Author(s)
  Kenichiro Mikami, Sachie Nakao, Reiichi Higashiyama, Hiroshi Fukumitsu, Tadashi Moro, Kaori Minakawa, Katsuto Hozumi, Isao Okazaki, Shinsaku Fukuda, Yutaka Inagaki
- Organizer
  The 62^<nd> Annual Meeting of The American Association for the Study of Liver Disease
- Place of Presentation
  San Francisco, USA
- Year and Date
  2011-11-07
- Data Source
  KAKENHI-PROJECT-23590991
[Presentation] Roles of Notch ligands : Delta-like 1 and Jagged1 in pancreas development2011
- Author(s)
  Nakano Y, Hozumi K, et al.
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-21390121
[Presentation] Delta-like 4 has particular significance for T cell development in the thymus2010
- Author(s)
  Hozumi K, et al.
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  Kobe、Japan
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-21390121
[Presentation] Delta like 4 has particular significance for T cell development in the thymus.2010
- Author(s)
  Hozumi K, et al.
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神再国際展示場(兵庫県)
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-21390121
[Presentation] Notch signals regulated hematopoietic homeostasis through osteoblastic niche maintenance.2010
- Author(s)
  六車ゆかり、八幡崇、弓野静、盛音、穂積勝人、安藤潔
- Organizer
  第72回日本血液学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-20590289
[Presentation] 骨芽細胞におけるDelta-like ligand1の発現が骨代謝維持に重要である2010
- Author(s)
  六車ゆかり、八幡崇、穂積勝人、安藤潔
- Organizer
  第28回日本骨代謝学会
- Place of Presentation
  京王プラザホテル
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PROJECT-20590289
[Presentation] Physiological significance of Delta-like 4 for the DN/DP transition in the thymus2010
- Author(s)
  Hirano K, Hozumi K, et al.
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  Kobe、Japan
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-21390121
[Presentation] Delta-like 4 has particular significance for T cell development in the thymus.2010
- Author(s)
  Hozumi K., et al.
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸国際展示場(兵庫県)
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PUBLICLY-22021040
[Presentation] Delta-like 4 is indispensable in thymic environment specific for T cell development2009
- Author(s)
  穂積勝人
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21390121
[Presentation] Delta-like 4 is indispensable in thymic environment specific for T cell development2009
- Author(s)
  Hozumi K, et al.
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21390121
[Presentation] The physiological significance of Notch ligands for pancreatic development2009
- Author(s)
  Nakano Y, Hozumi K, et al.
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-21390121
[Presentation] 胸腺内T細胞分化におけるDll4の生理的役割2009
- Author(s)
  穂積勝人, 他
- Organizer
  第39回日本免疫学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-21390121
[Presentation] The physiological significance of Notch ligands for pancreas development2009
- Author(s)
  中野泰博、穂積勝人
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-20057026
[Presentation] 胸腺環境要因としてのD114の役割2008
- Author(s)
  穂積勝人
- Organizer
  第38回日本免疫学会総会学術集会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-19390115
[Presentation] 胸腺分化環境要因としてのNotchリガンド : D114の役割2008
- Author(s)
  穂積勝人
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-20057026
[Presentation] 胸腺分化環境要因としてのNotchリガンド:Dll4の役割2008
- Author(s)
  穂積勝人
- Organizer
  、第31回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-19390115
[Presentation] 胸腺環境要因としてのD114の役割2008
- Author(s)
  穂積勝人
- Organizer
  第38回日本免疫学会総会学術集会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-20060024
[Presentation] 胸腺環境要因としてのD114の役割2008
- Author(s)
  穂積勝人
- Organizer
  第38回日本免疫学会総会学術集会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-20057026
[Presentation] 胸腺分化環境要因としてのNotchリガンド : D114の役割2008
- Author(s)
  穂積勝人
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-20060024
[Presentation] 胸腺分化環境要因としてのDll4の役割2008
- Author(s)
  穂積勝人
- Organizer
  第38回日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-19390115
[Presentation] 胸腺分化環境要因としてのNotchリガンド : D114の役割2008
- Author(s)
  穂積勝人
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-19390115
[Presentation] Dll4 expressed on thymic epithelial cells is required for T cell development in the thymus.2007
- Author(s)
  Hozumi, K., et. al.
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  グランドプリンスホテル新高輪
- Year and Date
  2007-11-21
- Data Source
  KAKENHI-PROJECT-18060040
[Presentation] Dll4 expressed on thymic epithelial cells is required for T cell development in the thymus2007
- Author(s)
  Hozumi, K., et al.
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  グランドプリンスホテル新高輪
- Year and Date
  2007-11-21
- Data Source
  KAKENHI-PROJECT-19390115
[Presentation] Dll4 expressed on thymic epithelial cells s required for T cell development in the thymus.2007
- Author(s)
  穂積勝人
- Organizer
  シンポジウム、第37回日本免疫学会学術集会
- Place of Presentation
  東京
- Year and Date
  2007-11-21
- Data Source
  KAKENHI-PROJECT-19390115

1. ANDO Kiyoshi (70176014)

# of Collaborated Projects: 5 results

# of Collaborated Products: 8 results
2. INAGAKI Yutaka (80193548)

# of Collaborated Projects: 4 results

# of Collaborated Products: 12 results
3. HABU Sonoko (30051618)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. 佐藤健人 (50235363)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. YAHATA Takashi (10398753)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. MINE Tetsuya (20157572)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. IMAI Kenji (70193646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NAKAYAMA Yukari (80398750)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. ASAHARA Takayuki (20246200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MIKAMI KENICHIRO (00375263)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. NISHIMURA Takashi (30143001)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HIRAYAMA Noriaki (70238393)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. IMAI Jin (40725363)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
14. KOTANI Ai (00517477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Masaharu Mori (00445389)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 紙谷聡英 (30321904)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
17. 住吉秀明 (60343357)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
18. 伊川友活 (60450392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 大塚正人 (90372945)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 渡邉稔彦 (50306734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 清水隆弘 (80626705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 佐藤慎二 (90276238)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 細野祐司 (60868090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. MORO Kazuyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 細川裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
26. 木村啓志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 中野泰博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 長澤丘司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 小安重夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 伊藤素行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 遠藤裕介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 中村雅登

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HOZUMI Katsuto 穂積 勝人

穂積 勝人 ホヅミ カツト

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The molecular analysis of the structural basis of Notch1/Dll4 interaction for drug discovery.Principal Investigator

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Significance of Notch signaling for the regulation of T cell response to gut-derived antigen as neo-selfPrincipal Investigator

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Molecular mechanisms for the maintenance of T cell differentiation potential and the determination of T cell fatePrincipal Investigator

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免疫四次元空間におけるNotchリガンドの役割解明Principal Investigator

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生体内T細胞環境要因としてのNotchリガンドの役割Principal Investigator

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Study for the determination of cell fates by NotchL as environment factorPrincipal Investigator

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HOZUMI Katsuto 穂積勝人

穂積勝人ホヅミカツト