HOZUMI Katsuto 穂積勝人

… Alternative Names

穂積勝人ホヅミカツト

Less

Researcher Number	30246079
Affiliation (Current)	2022: 東海大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2016 – 2021: 東海大学, 医学部, 教授 2015 – 2016: 東海大学, 医学部, 准教授 2007 – 2013: Tokai University, School of Medicine, Associate Professor 2005 – 2006: 東海大学, 医学部, 助教授 2001 – 2002: 東海大学, 医学部, 講師 1995 – 1998: 東海大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Biological Sciences / Immunology / Experimental pathology / Immunology / Basic Section 48040:Medical biochemistry-related Except Principal Investigator Gastroenterology / General medical chemistry / Immunology / Tumor therapeutics / Hematology / Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 54020:Connective tissue disease and allergy-related
Keywords	Principal Investigator T細胞 / Notch / 胸腺 / Notchリガンド / 分化 / GATA3 / TCR / 遺伝子再構成 / 膵臓 / Notchシグナル … More / パイエル板 / 骨髄 / 骨芽細胞 / Dll4 / Notch1 / CD3 / 脱メチル化 / T細胞レセプター / シスエレメント / 転写因子 / TCR遺伝子 / 転写制御 / 分化決定 / 胎仔胸腺器官培養 / IL-7 / Notch リガンド / NotchL / 細胞系譜 / Jaggedl / 初期発生 / Hes1 / Ngn3 / Ptf1a / 胸膜 / Jagged1 / 環境 / 増殖 / D114 / 発生病理 / 分化環境 / 膵臟 / Sox9 / 膵細胞 / 未分化性 / Cre/loxP / T cells / Notch ligand / 細胞外環境 / ILC2 / Notchシステム / Lmo2 / Bcl11a / Tcf1 / T細胞分化 / エピジェネティクス / Treg / Tfh / Tfh細胞 / Treg細胞 / Dll1 / 立体構造 / 結合様式 / シミュレーション … More Except Principal Investigator positive selection / Notch / TCR発現 / チロシンリン酸化 / 肝線維化 / DP胸腺細胞 / 再生医学 / 再生 / Notchシグナル / ZAP-70 / D111 / Jagged / 線維化 / MHC拘束性 TCR / MHC拘束性TCR / 骨と骨髄 / niche / 造血恒常性 / 骨代謝 / 骨芽細胞 / 造血代謝 / 造骨細胞 / 破骨細胞 / 幹前駆細胞 / Notch/Jagged-1シグナル / 肝線維症 / 肝再生 / Jagged-1 / 幹細胞 / 肝臓学 / コレセプター / positive slection / T細胞レセプター(TCR) / シグナル伝達 / TCRトランスジェニックマウス / CD4 / CD8 / TCR expression / tyrosine phosphorylation / coreceptor / トランジェニックマウス / Jagged1 / 外分泌 / 内分泌 / ノックアウトマウス / グルカゴン / トランスジェニックマウス / 外分泌細胞 / 内分泌細胞 / 膵 / Dll1 / Pdx-Cre / ER / 膵幹細胞 / リガンド / Noctch / Transgenicmouse / exocrine / endocrine / knockout mouse / Ptfla-Cre / 血液腫瘍 / T-ALL / Lmo2 / 抗腫瘍薬 / LMO2 / 悪性腫瘍 / 急性リンパ球性白血病 / 創薬 / クローン病 / 炎症性腸疾患 / 腸管線維化 / TGF-β / YB-1 / 肝前駆細胞 / 発癌 / 内科 / 発がん / 細胞分化 / microRNA / 転写因子 / B細胞分化 / EBF1 / 細胞運命 / miRNA / 血液免疫学 / 小腸移植 / 虚血再潅流障害 / 免疫応答 / 虚血再灌流障害 / Delta-like 4 / メモリーCD４T細胞 / 短腸症候群 / 抗MDA5抗体 / 皮膚筋炎 / 急速進行性間質性肺疾患 / 縦隔気腫 / 予後不良因子 / 免疫学 / 無筋症性皮膚筋炎 / 急速進行性間質性肺炎 Less

抗MDA5抗体陽性皮膚筋炎/急速進行性間質性肺炎の病態解明および新規治療法の開発
- Principal Investigator
  
  佐藤慎二
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Tokai University
The molecular analysis of the structural basis of Notch1/Dll4 interaction for drug discovery.Principal Investigator
- Principal Investigator
  
  穂積勝人
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Tokai University
Notch signaling in small bowel allograft rejection
- Principal Investigator
  
  Masaharu Mori
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Tokai University
Significance of Notch signaling for the regulation of T cell response to gut-derived antigen as neo-selfPrincipal Investigator
- Principal Investigator
  
  穂積勝人
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokai University
Identification of miRNA which rescues EBF1 deficiency indispensable for B cell lineage commitment
- Principal Investigator
  
  KOTANI Ai
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Tokai University
Molecular mechanisms for the maintenance of T cell differentiation potential and the determination of T cell fatePrincipal Investigator
- Principal Investigator
  
  HOZUMI Katsuto
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tokai University
The exploration of new drug for the treatment of Notch-active tumor cells.
- Principal Investigator
  
  ANDO Kiyoshi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor therapeutics
- Research Institution
  Tokai University
免疫四次元空間におけるNotchリガンドの役割解明Principal Investigator
- Principal Investigator
  
  穂積勝人
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokai University
Analysis of collagen producing cell and new therapeutic target of TGF-b signal in colorectal fibrosis
- Principal Investigator
  
  IMAI Jin
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokai University
Pathophysiological Interplay between Liver Fibrosis, Regeneration and Hepatocarcinogenesis from the Viewpoint of Stem/progenitor Cell Differentiation
- Principal Investigator
  
  INAGAKI Yutaka
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokai University
Pathophysiological correlation between fibrogenesis and regeneration in murine liver via Notch/Jagged-1 signal
- Principal Investigator
  
  MIKAMI KENICHIRO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hirosaki University
生体内T細胞環境要因としてのNotchリガンドの役割Principal Investigator
- Principal Investigator
  
  穂積勝人
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokai University
Regeneration of Fibrotic Liver through Modulation of Hepatic Stem Cell Niche and Differentiation of Bone Marrow Stem Cells
- Principal Investigator
  
  INAGAKI Yutaka
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokai University
Study for the determination of cell fates by NotchL as environment factorPrincipal Investigator
- Principal Investigator
  
  HOZUMI Katsuto
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokai University
分化環境要因としてのNotchリガンドの役割Principal Investigator
- Principal Investigator
  
  穂積勝人
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokai University
胸腺の存在をDll4でどこまで解くことができるのかPrincipal Investigator
- Principal Investigator
  
  穂積勝人
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokai University
Identification of molecular mechanisms that link bone remodeling and hematopoietic homeostasis
- Principal Investigator
  
  NAKAYAMA Yukari
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokai University
Analysis of the molecular mechanism for the determination of cell fate and the tissue organization with Notch signalingPrincipal Investigator
- Principal Investigator
  
  HOZUMI Katsuto
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokai University
分化環境要因としてのNotchリガンドの役割Principal Investigator
- Principal Investigator
  
  穂積勝人
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokai University
Investigative of diffentiation of pancreatic cells and application for treatments for chronic pancreatitis
- Principal Investigator
  
  MINE Tetsuya
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokai University
Pre-thymic Notch signaling is necessary for GATA3 function in the initiation of T cell development.Principal Investigator
- Principal Investigator
  
  HOZUMI Katsuto
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tokai University
T細胞分化決定における分子機構の解析Principal Investigator
- Principal Investigator
  
  穂積勝人
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Tokai University
T細胞分化過程におけるTCR遺伝子高次構造制御の分子機構Principal Investigator
- Principal Investigator
  
  穂積勝人
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Immunology
- Research Institution
  Tokai University
胸腺内分化過程におけるT細胞レセプターの遺伝子再構築を抑制する分子機構
- Principal Investigator
  
  垣生園子
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokai University
T細胞分化決定にともなうTCRβ遺伝子の転写と再構成の機構解明Principal Investigator
- Principal Investigator
  
  穂積勝人
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Immunology
- Research Institution
  Tokai University
胸腺内分化モデルの確立による自己認識T細胞クローンの選択機構の解析
- Principal Investigator
  
  HABU Sonoko
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokai University
T細胞初期分化における分子機構の解明Principal Investigator
- Principal Investigator
  
  穂積勝人
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Immunology
- Research Institution
  Tokai University
The molecular mechanism of TCR repertoire generation and coreceptor expression
- Principal Investigator
  
  HABU Sonoko
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Tokai University

All 2022 2021 2020 2018 2017 2016 2015 2011 2010 2009 2008 2007 2006

All Journal Article Presentation Book

[Book] 胸腺内T細胞分化におけるDll4/Notchシグナルの役割、臨床免疫・アレルギー科2011
- Author(s)
  穂積勝人
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-21390121
[Book] 胸腺分化環境要因としてのDelta-like 4の役割、臨床免疫・アレルギー科2009
- Author(s)
  穂積勝人
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-21390121
[Journal Article] Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium2022
- Author(s)
  Hirano KI, Hosokawa H, Yahata T, Ando K, Tanaka M, Imai J, Yazawa M, Ohtsuka M, Negishi N, Habu S, Sato T, Hozumi K.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 852427-852427
- DOI
  10.3389/fimmu.2022.852427
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17413, KAKENHI-PROJECT-19H03692, KAKENHI-PROJECT-20K07330
[Journal Article] Notch signaling supports the appearance of follicular helper T cells in the Peyer’s patches concomitantly with the reduction of regulatory T cells2021
- Author(s)
  Yazawa M, Hosokawa H, Koizumi M, Hirano KI, Imai J, Hozumi K.
- Journal Title
  
  International Immunology
  
  Volume: 33(9) Pages: 469-478
- DOI
  10.1093/intimm/dxab032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17413, KAKENHI-PROJECT-19H03692, KAKENHI-PROJECT-20K07330
[Journal Article] LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice2021
- Author(s)
  Hirano K., Hosokawa H., Koizumi M., Endo Y., Yahata T., and Hozumi K
- Journal Title
  
  eLife
  
  Volume: 10
- DOI
  10.7554/elife.68227
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21618, KAKENHI-PROJECT-19H03692, KAKENHI-PROJECT-20H03455, KAKENHI-PROJECT-21H02767, KAKENHI-PROJECT-20K07330
[Journal Article] Peripheral PDGFRa+gp38+ mesenchymal cells support the differentiation of fetal liver-derived ILC22018
- Author(s)
  Koga, S., Hozumi, K., Hirano, K.I., Yazawa, M., Terooatea, T., Minoda, A., Nagasawa, T., Koyasu, S., and Moro, K.
- Journal Title
  
  The Journal of Experimental Medicine
  
  Volume: 215 Pages: 1609-1626
- DOI
  10.1084/jem.20172310
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05643, KAKENHI-PUBLICLY-17H05802, KAKENHI-PROJECT-18H05286, KAKENHI-PROJECT-16H02631, KAKENHI-PROJECT-18H03998, KAKENHI-PROJECT-16K08848
[Journal Article] Identification of a novel alpha-fetoprotein-expressing cell population induced by the Jagged 1/Notch 2 signal in murine fibrotic liver.2017
- Author(s)
  Yasuhiro Nakano, Sachie Nakao, Hideaki Sumiyoshi, Kenichiro Mikami, Yuri Tanno, Minako Sueoka, Daigo Kasahara, Hiroshi Kimura, Tadashi Moro, Akihide Kamiya, Katsuto Hozumi, Yutaka Inagaki
- Journal Title
  
  Hepatology Communications
  
  Volume: 印刷中 Pages: 1-15
- DOI
  10.1002/hep4.1026
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293179, KAKENHI-PROJECT-15K15299, KAKENHI-PROJECT-15K10071, KAKENHI-PROJECT-26293178, KAKENHI-PROJECT-16K15434, KAKENHI-PROJECT-16K19369, KAKENHI-PROJECT-17H04166
[Journal Article] Identification of Domains for Efficient Notch Signaling Activity in Immobilized Notch Ligand Proteins.2017
- Author(s)
  Liu L, Wada H, Matsubara N, Hozumi K and Itoh M.
- Journal Title
  
  J Cell Biochem
  
  Volume: 118 Pages: 785-796
- DOI
  10.1002/jcb.25744
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01161, KAKENHI-PROJECT-25670020
[Journal Article] Jagged1-induced Notch activation contributes to the acquisition of bortezomib resistance in myeloma cells2017
- Author(s)
  Yukari Muguruma, Takashi Yahata, Takayuki Warita, Katsuyo Hozumi, Yoshihiko Nakamura, Rikio Suzuki, Mamoru Ito, Kiyoshi Ando
- Journal Title
  
  Blood Cancer J.
  
  Volume: 7 Pages: 1007-1012
- DOI
  10.1038/s41408-017-0001-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04287, KAKENHI-PROJECT-15H04301, KAKENHI-PROJECT-17H03572, KAKENHI-PROJECT-16K14635
[Journal Article] Jun Abe, Kiyoshi Higashi, Yutaka Inagaki, and Tetsuya Mine: Anti-fibrotic effects of a novel small compound on the regulation of cytokine production in a mouse model of colorectal fibrosis.2015
- Author(s)
  Imai J, Hozumi K, Sumiyoshi H, Yazawa M, Hirano K, Abe J, Higashi K, Inagaki Y, Mine T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 468 Pages: 554-560
- DOI
  10.1016/j.bbrc.2015.10.123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10071, KAKENHI-PROJECT-15K15299, KAKENHI-PROJECT-25293179
[Journal Article] Delta-like 4-mediated Notch signaling is required for early T cell development in a three-dimensional thymic structure2015
- Author(s)
  Hirano K, Negishi N, Yazawa M, Yagita H, Habu S, Hozumi K
- Journal Title
  
  European Journal of Immunology
  
  Volume: 45 Pages: 2252-2262
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01161
[Journal Article] Anti-fibrotic effects of a novel small compound on the regulation of cytokine production in a mouse model of colorectal fibrosis.2015
- Author(s)
  Imai J, Hozumi K, Sumiyoshi H, Yazawa M, Hirano K, Abe J, Higashi K, Inagaki Y, Mine T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 468(4) Pages: 554-560
- DOI
  10.1155/2016/2964581
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19353
[Journal Article] Notch ligands transduce different magnitudes of signaling critical for determination of T-cell fate2011
- Author(s)
  Abe N, Hozumi K, Hirano K, Yagita H and Habu S
- Journal Title
  
  Eur. J. Immunol
  
  Volume: 40 Pages: 2608-2617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390121
[Journal Article] Notch signaling is necessary for GATA3 function in the initiation of T cell development2008
- Author(s)
  Hozumi K., et.al.
- Journal Title
  
  European Journal of Immunology 38
  
  Pages: 977-985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20057026
[Journal Article] Expression of Delta-like 1 in the splenic non-hematopoietic cells is essential for marginal zone B cell development.2008
- Author(s)
  Sheng, Y., Yahata, T., Negishi, N., Nakano, Y., Habu, S., Hozumi, K. and Ando, K.
- Journal Title
  
  Immunol. Lett. 121
  
  Pages: 33-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390115
[Journal Article] Notch signaling is necessary for GATA3 function in the initiation of T cell development.2008
- Author(s)
  Hozumi K., et al.
- Journal Title
  
  European Journal of Immunology 38
  
  Pages: 977-985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390115
[Journal Article] Notch signaling is necessary for GATA3 function in the initiation of T cell development.2008
- Author(s)
  Hozumi, K., Negishi, N., Tsuchiya, I., Abe, N., Hirano, K., Suzuki, D., Yamamoto, M., Engel, J. D. and Habu, S.
- Journal Title
  
  Eur. J. Immunol. 38
  
  Pages: 977-985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390115
[Journal Article] Delta-like 4 is indispensable in thymic environment specific for T cell development.2008
- Author(s)
  Hozumi K., et al.
- Journal Title
  
  Journal of Experimental Medicine 205
  
  Pages: 2507-2513
- NAID
  40016715345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390115
[Journal Article] Delta-like 4 is indispensable in thymic environment spe cific for T cell development2008
- Author(s)
  Hozumi K., et.al.
- Journal Title
  
  Journal of Experimental Medicine 205
  
  Pages: 2507-2513
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20060024
[Journal Article] Delta-like 4 is indispensable in thymic environment specific for T cell development2008
- Author(s)
  Hozumi K., et.al.
- Journal Title
  
  Journal of Experimental Medicine 205
  
  Pages: 2507-2513
- NAID
  40016715345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20057026
[Journal Article] Notch signaling is necessary for GATA3 function in the initiation of T cell development2008
- Author(s)
  Hozumi K., et.al.
- Journal Title
  
  European Journal of Immunology 38
  
  Pages: 977-985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20060024
[Journal Article] Delta-like 4 is indispensable in thymic environment specific for T cell development.2008
- Author(s)
  Hozumi, K., Mailhos, C., Negishi, N., Hirano, K., Yahata, T., Ando, K., Zuklys, S., Hollander, G. A., Shima, D. T. and Habu, S.
- Journal Title
  
  J. Exp. Med. 205
  
  Pages: 2507-2513
- NAID
  40016715345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390115
[Journal Article] Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo.2007
- Author(s)
  Oyama, T., Harigaya, K., Muradil, A., Hozumi, K., Habu, S., Iwama, A., Oguro, H., Matsuno, K., Sakamoto, R., Sato, M., Yoshida, N. and Kitagawa, M.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA. 104
  
  Pages: 9764-9769
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390115
[Journal Article] Jaggedl is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis.2006
- Author(s)
  Estrach S, Ambler CA, Lo Celso C, Hozumi K, Watt FM
- Journal Title
  
  Development 133
  
  Pages: 4427-4438
- Data Source
  KAKENHI-PROJECT-18060040
[Journal Article] Notch ligands with contrasting functions : Jaggedi and Delral in the mouse inner ear.2006
- Author(s)
  Brooker R, Hozumi K, Lewis J
- Journal Title
  
  Development 133
  
  Pages: 1277-1286
- Data Source
  KAKENHI-PROJECT-18060040
[Presentation] Dll1 and Dll4 differently require their extracellular domains for triggering Notch signaling in mice2020
- Author(s)
  穂積勝人
- Organizer
  日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07330
[Presentation] The epigenetic regulation of gene loci encoding transcription factor critical for the determination of T/B-cell lineages by Lmo22018
- Author(s)
  Hozumi K, Hirano KI
- Organizer
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-16K08848
[Presentation] Molecular machinery for the maintenance of differentiation potential toward T/B cell lineages in hematopoietic stem/progenitor cells by Lmo22017
- Author(s)
  Katsuto Hozumi, Shuhei Ochiai, Ken-ichi Hirano
- Organizer
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-16K08848
[Presentation] Jagged1/Notchシグナルを介した線維肝再生における前駆細胞動員機構の解明．2017
- Author(s)
  中野泰博、中尾祥絵、住吉秀明、三上健一郎、丹野友里、末岡美那子、笠原大瑚、木村啓志、茂呂　忠、紙谷聡英、穂積勝人、稲垣　豊
- Organizer
  第16回日本再生医療学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-09
- Data Source
  KAKENHI-PROJECT-25293179
[Presentation] Molecular machinery for the maintenance of differentiation potential toward T/B cell lineages in hematopoietic stem/progenitor cells by Lmo22017
- Author(s)
  Hozumi K、Ochiai S、Hirano K
- Organizer
  日本免疫学会・学術集会
- Data Source
  KAKENHI-PROJECT-16K14635
[Presentation] Dll4-mediated Notch1 signaling is required for the conversion from Treg to Tfh in Peyers patch.2016
- Author(s)
  Yazawa M and Hozumi K
- Organizer
  日本免疫学会・学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PUBLICLY-15H01161
[Presentation] Essential role of Lmo2 for the maintenance of T-cell differentiation potential in Ebf1-deficient pro-B cells.2016
- Author(s)
  Hozumi K、Ochiai S、Hirano K
- Organizer
  日本免疫学会・学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K08848
[Presentation] Anti-fibrotic effects of a novel small compound that promotes the nuclear translocation of YB-1 in a mouse model of colorectal fibrosis.2016
- Author(s)
  Imai J, Hozumi K, Inagaki Y, Mine T.
- Organizer
  European Crohn's and Colitis Organisation 2016
- Place of Presentation
  ＲＡＩ Amsterdam (Netherlands)
- Year and Date
  2016-03-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19353
[Presentation] Contribution of Jagged1/Notch signaling to murine fibrotic liver regeneration through possible dedifferentiation of mature hepatocytes.2016
- Author(s)
  Yasuhiro Nakano, Sachie Nakao, Hideaki Sumiyoshi, Kenichiro Mikami, Yuri Tanno, Daigo Kasahara, Hiroshi Kimura, Tadashi Moro, Akihide Kamiya, Katsuto Hozumi, Yutaka Inagaki
- Organizer
  67th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Hynes Convention Center (Boston, MA, U.S.A.)
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293179
[Presentation] YB-1の核内移行を促進させる小化合物を用いたクローン病腸管線維化モデルに対する抗線維化治療の検討2016
- Author(s)
  今井　仁、峯　徹哉、稲垣　豊、穂積　勝人
- Organizer
  第102回に本消化器病学会総会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-15K19353
[Presentation] Essential role of Lmo2 for the maintenance of T-cell differentiation potential in Ebf1-deficient pro-B cells2016
- Author(s)
  Hozumi K、Ochiai S、Hirano K
- Organizer
  日本免疫学会・学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K14635
[Presentation] 肝発生および線維肝再生過程における肝前駆細胞は、間葉系細胞のJagged-1をリガンドとするNotchシグナルによって制御される．2016
- Author(s)
  中野泰博、中尾祥絵、住吉秀明、三上健一郎、丹野友里、茂呂　忠、紙谷聡英、穂積勝人、稲垣　豊
- Organizer
  第23回肝細胞研究会
- Place of Presentation
  大阪大学中之島センター（大阪府大阪市）
- Year and Date
  2016-07-07
- Data Source
  KAKENHI-PROJECT-25293179
[Presentation] Contribution of Jagged1/Notch signaling to murine fibrotic liver regeneration through possible dedifferentiation of mature hepatocytes.2016
- Author(s)
  Yasuhiro Nakano, Sachie Nakao, Hideaki Sumiyoshi, Kenichiro Mikami, Yuri Tanno, Minako Sueoka, Daigo Kasahara, Hiroshi Kimura, Tadashi Moro, Akihide Kamiya, Katsuto Hozumi, Yutaka Inagaki
- Organizer
  9th Notch Meeting
- Place of Presentation
  国立遺伝学研究所（静岡県三島市）
- Year and Date
  2016-10-05
- Data Source
  KAKENHI-PROJECT-25293179
[Presentation] Jagged1/Notchシグナルは線維肝再生における肝前駆細胞の動員に機能する．2016
- Author(s)
  中野泰博、中尾祥絵、住吉秀明、三上健一郎、丹野友里、末岡美那子、笠原大瑚、木村啓志、茂呂　忠、紙谷聡英、穂積勝人、稲垣　豊
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-25293179
[Presentation] The structure-function relationship in Dll1/Dll4 chimeric molecules for supporting T cell development2015
- Author(s)
  Hozumi K, Ochiai, S, Hirano K
- Organizer
  日本分子生物学会年会
- Place of Presentation
  兵庫県神戸市・神戸コンベンションセンター
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PUBLICLY-15H01161
[Presentation] Kaori Minakawa, Katsuto Hozumi, Isao Okazaki, Shinsaku Fukuda, Yutaka Inagaki. Notch/Jagged-1 signal modulates pathophysiological correlation between fibrogenesis and regeneration in murine liver2011
- Author(s)
  Kenichiro Mikami, Sachie Nakao, Reiichi Higashiyama, Hiroshi Fukumitsu, Tadashi Moro, Kaori Minakawa, Katsuto Hozumi, Isao Okazaki, Shinsaku Fukuda, Yutaka Inagaki
- Organizer
  The 62^<nd> Annual Meeting of The American Association for the Study of Liver Disease
- Place of Presentation
  San Francisco, USA
- Year and Date
  2011-11-07
- Data Source
  KAKENHI-PROJECT-23590991
[Presentation] Roles of Notch ligands : Delta-like 1 and Jagged1 in pancreas development2011
- Author(s)
  Nakano Y, Hozumi K, et al.
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-21390121
[Presentation] Delta-like 4 has particular significance for T cell development in the thymus2010
- Author(s)
  Hozumi K, et al.
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  Kobe、Japan
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-21390121
[Presentation] Delta like 4 has particular significance for T cell development in the thymus.2010
- Author(s)
  Hozumi K, et al.
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神再国際展示場(兵庫県)
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-21390121
[Presentation] Notch signals regulated hematopoietic homeostasis through osteoblastic niche maintenance.2010
- Author(s)
  六車ゆかり、八幡崇、弓野静、盛音、穂積勝人、安藤潔
- Organizer
  第72回日本血液学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-20590289
[Presentation] 骨芽細胞におけるDelta-like ligand1の発現が骨代謝維持に重要である2010
- Author(s)
  六車ゆかり、八幡崇、穂積勝人、安藤潔
- Organizer
  第28回日本骨代謝学会
- Place of Presentation
  京王プラザホテル
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PROJECT-20590289
[Presentation] Physiological significance of Delta-like 4 for the DN/DP transition in the thymus2010
- Author(s)
  Hirano K, Hozumi K, et al.
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  Kobe、Japan
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-21390121
[Presentation] Delta-like 4 has particular significance for T cell development in the thymus.2010
- Author(s)
  Hozumi K., et al.
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸国際展示場(兵庫県)
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PUBLICLY-22021040
[Presentation] Delta-like 4 is indispensable in thymic environment specific for T cell development2009
- Author(s)
  穂積勝人
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21390121
[Presentation] Delta-like 4 is indispensable in thymic environment specific for T cell development2009
- Author(s)
  Hozumi K, et al.
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21390121
[Presentation] The physiological significance of Notch ligands for pancreatic development2009
- Author(s)
  Nakano Y, Hozumi K, et al.
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-21390121
[Presentation] 胸腺内T細胞分化におけるDll4の生理的役割2009
- Author(s)
  穂積勝人, 他
- Organizer
  第39回日本免疫学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-21390121
[Presentation] The physiological significance of Notch ligands for pancreas development2009
- Author(s)
  中野泰博、穂積勝人
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-20057026
[Presentation] 胸腺環境要因としてのD114の役割2008
- Author(s)
  穂積勝人
- Organizer
  第38回日本免疫学会総会学術集会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-19390115
[Presentation] 胸腺分化環境要因としてのNotchリガンド : D114の役割2008
- Author(s)
  穂積勝人
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-20057026
[Presentation] 胸腺分化環境要因としてのNotchリガンド:Dll4の役割2008
- Author(s)
  穂積勝人
- Organizer
  、第31回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-19390115
[Presentation] 胸腺環境要因としてのD114の役割2008
- Author(s)
  穂積勝人
- Organizer
  第38回日本免疫学会総会学術集会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-20060024
[Presentation] 胸腺環境要因としてのD114の役割2008
- Author(s)
  穂積勝人
- Organizer
  第38回日本免疫学会総会学術集会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-20057026
[Presentation] 胸腺分化環境要因としてのNotchリガンド : D114の役割2008
- Author(s)
  穂積勝人
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-20060024
[Presentation] 胸腺分化環境要因としてのDll4の役割2008
- Author(s)
  穂積勝人
- Organizer
  第38回日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-19390115
[Presentation] 胸腺分化環境要因としてのNotchリガンド : D114の役割2008
- Author(s)
  穂積勝人
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-19390115
[Presentation] Dll4 expressed on thymic epithelial cells is required for T cell development in the thymus.2007
- Author(s)
  Hozumi, K., et. al.
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  グランドプリンスホテル新高輪
- Year and Date
  2007-11-21
- Data Source
  KAKENHI-PROJECT-18060040
[Presentation] Dll4 expressed on thymic epithelial cells is required for T cell development in the thymus2007
- Author(s)
  Hozumi, K., et al.
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  グランドプリンスホテル新高輪
- Year and Date
  2007-11-21
- Data Source
  KAKENHI-PROJECT-19390115
[Presentation] Dll4 expressed on thymic epithelial cells s required for T cell development in the thymus.2007
- Author(s)
  穂積勝人
- Organizer
  シンポジウム、第37回日本免疫学会学術集会
- Place of Presentation
  東京
- Year and Date
  2007-11-21
- Data Source
  KAKENHI-PROJECT-19390115

1. ANDO Kiyoshi (70176014)

# of Collaborated Projects: 5 results

# of Collaborated Products: 8 results
2. INAGAKI Yutaka (80193548)

# of Collaborated Projects: 4 results

# of Collaborated Products: 12 results
3. HABU Sonoko (30051618)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. 佐藤健人 (50235363)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. YAHATA Takashi (10398753)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. MINE Tetsuya (20157572)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. IMAI Kenji (70193646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NAKAYAMA Yukari (80398750)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. ASAHARA Takayuki (20246200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MIKAMI KENICHIRO (00375263)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. NISHIMURA Takashi (30143001)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HIRAYAMA Noriaki (70238393)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. IMAI Jin (40725363)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
14. KOTANI Ai (00517477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Masaharu Mori (00445389)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 紙谷聡英 (30321904)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
17. 住吉秀明 (60343357)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
18. 伊川友活 (60450392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 大塚正人 (90372945)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 渡邉稔彦 (50306734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 清水隆弘 (80626705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 佐藤慎二 (90276238)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 細野祐司 (60868090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. MORO Kazuyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 細川裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
26. 木村啓志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 中野泰博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 長澤丘司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 小安重夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 伊藤素行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 遠藤裕介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 中村雅登

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HOZUMI Katsuto 穂積 勝人

穂積 勝人 ホヅミ カツト

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The molecular analysis of the structural basis of Notch1/Dll4 interaction for drug discovery.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Significance of Notch signaling for the regulation of T cell response to gut-derived antigen as neo-selfPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms for the maintenance of T cell differentiation potential and the determination of T cell fatePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

免疫四次元空間におけるNotchリガンドの役割解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

生体内T細胞環境要因としてのNotchリガンドの役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study for the determination of cell fates by NotchL as environment factorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

HOZUMI Katsuto 穂積勝人

穂積勝人ホヅミカツト