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HOZUMI Katsuto  穂積 勝人

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… Alternative Names

穂積 勝人  ホヅミ カツト

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Researcher Number 30246079
Affiliation (Current) 2022: 東海大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2016 – 2021: 東海大学, 医学部, 教授
2015 – 2016: 東海大学, 医学部, 准教授
2007 – 2013: Tokai University, School of Medicine, Associate Professor
2005 – 2006: 東海大学, 医学部, 助教授
2001 – 2002: 東海大学, 医学部, 講師
1995 – 1998: 東海大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Biological Sciences / Immunology / Experimental pathology / Immunology / Basic Section 48040:Medical biochemistry-related
Except Principal Investigator
Gastroenterology / General medical chemistry / Immunology / Tumor therapeutics / Hematology / Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 54020:Connective tissue disease and allergy-related
Keywords
Principal Investigator
T細胞 / Notch / 胸腺 / Notchリガンド / 分化 / GATA3 / TCR / 遺伝子再構成 / 膵臓 / Notchシグナル … More / パイエル板 / 骨髄 / 骨芽細胞 / Dll4 / Notch1 / CD3 / 脱メチル化 / T細胞レセプター / シスエレメント / 転写因子 / TCR遺伝子 / 転写制御 / 分化決定 / 胎仔胸腺器官培養 / IL-7 / Notch リガンド / NotchL / 細胞系譜 / Jaggedl / 初期発生 / Hes1 / Ngn3 / Ptf1a / 胸膜 / Jagged1 / 環境 / 増殖 / D114 / 発生病理 / 分化環境 / 膵臟 / Sox9 / 膵細胞 / 未分化性 / Cre/loxP / T cells / Notch ligand / 細胞外環境 / ILC2 / Notchシステム / Lmo2 / Bcl11a / Tcf1 / T細胞分化 / エピジェネティクス / Treg / Tfh / Tfh細胞 / Treg細胞 / Dll1 / 立体構造 / 結合様式 / シミュレーション … More
Except Principal Investigator
positive selection / Notch / TCR発現 / チロシンリン酸化 / 肝線維化 / DP胸腺細胞 / 再生医学 / 再生 / Notchシグナル / ZAP-70 / D111 / Jagged / 線維化 / MHC拘束性 TCR / MHC拘束性TCR / 骨と骨髄 / niche / 造血恒常性 / 骨代謝 / 骨芽細胞 / 造血代謝 / 造骨細胞 / 破骨細胞 / 幹前駆細胞 / Notch/Jagged-1シグナル / 肝線維症 / 肝再生 / Jagged-1 / 幹細胞 / 肝臓学 / コレセプター / positive slection / T細胞レセプター(TCR) / シグナル伝達 / TCRトランスジェニックマウス / CD4 / CD8 / TCR expression / tyrosine phosphorylation / coreceptor / トランジェニックマウス / Jagged1 / 外分泌 / 内分泌 / ノックアウトマウス / グルカゴン / トランスジェニックマウス / 外分泌細胞 / 内分泌細胞 / 膵 / Dll1 / Pdx-Cre / ER / 膵幹細胞 / リガンド / Noctch / Transgenicmouse / exocrine / endocrine / knockout mouse / Ptfla-Cre / 血液腫瘍 / T-ALL / Lmo2 / 抗腫瘍薬 / LMO2 / 悪性腫瘍 / 急性リンパ球性白血病 / 創薬 / クローン病 / 炎症性腸疾患 / 腸管線維化 / TGF-β / YB-1 / 肝前駆細胞 / 発癌 / 内科 / 発がん / 細胞分化 / microRNA / 転写因子 / B細胞分化 / EBF1 / 細胞運命 / miRNA / 血液免疫学 / 小腸移植 / 虚血再潅流障害 / 免疫応答 / 虚血再灌流障害 / Delta-like 4 / メモリーCD4T細胞 / 短腸症候群 / 抗MDA5抗体 / 皮膚筋炎 / 急速進行性間質性肺疾患 / 縦隔気腫 / 予後不良因子 / 免疫学 / 無筋症性皮膚筋炎 / 急速進行性間質性肺炎 Less
  • Research Projects

    (28 results)
  • Research Products

    (64 results)
  • Co-Researchers

    (32 People)
  •  抗MDA5抗体陽性皮膚筋炎/急速進行性間質性肺炎の病態解明および新規治療法の開発

    • Principal Investigator
      佐藤 慎二
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54020:Connective tissue disease and allergy-related
    • Research Institution
      Tokai University
  •  The molecular analysis of the structural basis of Notch1/Dll4 interaction for drug discovery.Principal Investigator

    • Principal Investigator
      穂積 勝人
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      Tokai University
  •  Notch signaling in small bowel allograft rejection

    • Principal Investigator
      Masaharu Mori
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Tokai University
  •  Significance of Notch signaling for the regulation of T cell response to gut-derived antigen as neo-selfPrincipal Investigator

    • Principal Investigator
      穂積 勝人
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokai University
  •  Identification of miRNA which rescues EBF1 deficiency indispensable for B cell lineage commitment

    • Principal Investigator
      KOTANI Ai
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Tokai University
  •  Molecular mechanisms for the maintenance of T cell differentiation potential and the determination of T cell fatePrincipal Investigator

    • Principal Investigator
      HOZUMI Katsuto
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Tokai University
  •  The exploration of new drug for the treatment of Notch-active tumor cells.

    • Principal Investigator
      ANDO Kiyoshi
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Tumor therapeutics
    • Research Institution
      Tokai University
  •  免疫四次元空間におけるNotchリガンドの役割解明Principal Investigator

    • Principal Investigator
      穂積 勝人
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokai University
  •  Analysis of collagen producing cell and new therapeutic target of TGF-b signal in colorectal fibrosis

    • Principal Investigator
      IMAI Jin
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokai University
  •  Pathophysiological Interplay between Liver Fibrosis, Regeneration and Hepatocarcinogenesis from the Viewpoint of Stem/progenitor Cell Differentiation

    • Principal Investigator
      INAGAKI Yutaka
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokai University
  •  Pathophysiological correlation between fibrogenesis and regeneration in murine liver via Notch/Jagged-1 signal

    • Principal Investigator
      MIKAMI KENICHIRO
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Hirosaki University
  •  生体内T細胞環境要因としてのNotchリガンドの役割Principal Investigator

    • Principal Investigator
      穂積 勝人
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokai University
  •  Regeneration of Fibrotic Liver through Modulation of Hepatic Stem Cell Niche and Differentiation of Bone Marrow Stem Cells

    • Principal Investigator
      INAGAKI Yutaka
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokai University
  •  Study for the determination of cell fates by NotchL as environment factorPrincipal Investigator

    • Principal Investigator
      HOZUMI Katsuto
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Tokai University
  •  分化環境要因としてのNotchリガンドの役割Principal Investigator

    • Principal Investigator
      穂積 勝人
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokai University
  •  胸腺の存在をDll4でどこまで解くことができるのかPrincipal Investigator

    • Principal Investigator
      穂積 勝人
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokai University
  •  Identification of molecular mechanisms that link bone remodeling and hematopoietic homeostasis

    • Principal Investigator
      NAKAYAMA Yukari
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Tokai University
  •  Analysis of the molecular mechanism for the determination of cell fate and the tissue organization with Notch signalingPrincipal Investigator

    • Principal Investigator
      HOZUMI Katsuto
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Tokai University
  •  分化環境要因としてのNotchリガンドの役割Principal Investigator

    • Principal Investigator
      穂積 勝人
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokai University
  •  Investigative of diffentiation of pancreatic cells and application for treatments for chronic pancreatitis

    • Principal Investigator
      MINE Tetsuya
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokai University
  •  Pre-thymic Notch signaling is necessary for GATA3 function in the initiation of T cell development.Principal Investigator

    • Principal Investigator
      HOZUMI Katsuto
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Tokai University
  •  T細胞分化決定における分子機構の解析Principal Investigator

    • Principal Investigator
      穂積 勝人
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Immunology
    • Research Institution
      Tokai University
  •  T細胞分化過程におけるTCR遺伝子高次構造制御の分子機構Principal Investigator

    • Principal Investigator
      穂積 勝人
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Immunology
    • Research Institution
      Tokai University
  •  胸腺内分化過程におけるT細胞レセプターの遺伝子再構築を抑制する分子機構

    • Principal Investigator
      垣生 園子
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokai University
  •  T細胞分化決定にともなうTCRβ遺伝子の転写と再構成の機構解明Principal Investigator

    • Principal Investigator
      穂積 勝人
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Immunology
    • Research Institution
      Tokai University
  •  胸腺内分化モデルの確立による自己認識T細胞クローンの選択機構の解析

    • Principal Investigator
      HABU Sonoko
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokai University
  •  T細胞初期分化における分子機構の解明Principal Investigator

    • Principal Investigator
      穂積 勝人
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Immunology
    • Research Institution
      Tokai University
  •  The molecular mechanism of TCR repertoire generation and coreceptor expression

    • Principal Investigator
      HABU Sonoko
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Tokai University

All 2022 2021 2020 2018 2017 2016 2015 2011 2010 2009 2008 2007 2006

All Journal Article Presentation Book

  • [Book] 胸腺内T細胞分化におけるDll4/Notchシグナルの役割、臨床免疫・アレルギー科2011

    • Author(s)
      穂積勝人
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-21390121
  • [Book] 胸腺分化環境要因としてのDelta-like 4の役割、臨床免疫・アレルギー科2009

    • Author(s)
      穂積勝人
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-21390121
  • [Journal Article] Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium2022

    • Author(s)
      Hirano KI, Hosokawa H, Yahata T, Ando K, Tanaka M, Imai J, Yazawa M, Ohtsuka M, Negishi N, Habu S, Sato T, Hozumi K.
    • Journal Title

      Frontiers in Immunology

      Volume: 13 Pages: 852427-852427

    • DOI

      10.3389/fimmu.2022.852427

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K17413, KAKENHI-PROJECT-19H03692, KAKENHI-PROJECT-20K07330
  • [Journal Article] Notch signaling supports the appearance of follicular helper T cells in the Peyer’s patches concomitantly with the reduction of regulatory T cells2021

    • Author(s)
      Yazawa M, Hosokawa H, Koizumi M, Hirano KI, Imai J, Hozumi K.
    • Journal Title

      International Immunology

      Volume: 33(9) Pages: 469-478

    • DOI

      10.1093/intimm/dxab032

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K17413, KAKENHI-PROJECT-19H03692, KAKENHI-PROJECT-20K07330
  • [Journal Article] LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice2021

    • Author(s)
      Hirano K., Hosokawa H., Koizumi M., Endo Y., Yahata T., and Hozumi K
    • Journal Title

      eLife

      Volume: 10

    • DOI

      10.7554/elife.68227

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K21618, KAKENHI-PROJECT-19H03692, KAKENHI-PROJECT-20H03455, KAKENHI-PROJECT-21H02767, KAKENHI-PROJECT-20K07330
  • [Journal Article] Peripheral PDGFRa+gp38+ mesenchymal cells support the differentiation of fetal liver-derived ILC22018

    • Author(s)
      Koga, S., Hozumi, K., Hirano, K.I., Yazawa, M., Terooatea, T., Minoda, A., Nagasawa, T., Koyasu, S., and Moro, K.
    • Journal Title

      The Journal of Experimental Medicine

      Volume: 215 Pages: 1609-1626

    • DOI

      10.1084/jem.20172310

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05643, KAKENHI-PUBLICLY-17H05802, KAKENHI-PROJECT-18H05286, KAKENHI-PROJECT-16H02631, KAKENHI-PROJECT-18H03998, KAKENHI-PROJECT-16K08848
  • [Journal Article] Identification of a novel alpha-fetoprotein-expressing cell population induced by the Jagged 1/Notch 2 signal in murine fibrotic liver.2017

    • Author(s)
      Yasuhiro Nakano, Sachie Nakao, Hideaki Sumiyoshi, Kenichiro Mikami, Yuri Tanno, Minako Sueoka, Daigo Kasahara, Hiroshi Kimura, Tadashi Moro, Akihide Kamiya, Katsuto Hozumi, Yutaka Inagaki
    • Journal Title

      Hepatology Communications

      Volume: 印刷中 Pages: 1-15

    • DOI

      10.1002/hep4.1026

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25293179, KAKENHI-PROJECT-15K15299, KAKENHI-PROJECT-15K10071, KAKENHI-PROJECT-26293178, KAKENHI-PROJECT-16K15434, KAKENHI-PROJECT-16K19369, KAKENHI-PROJECT-17H04166
  • [Journal Article] Identification of Domains for Efficient Notch Signaling Activity in Immobilized Notch Ligand Proteins.2017

    • Author(s)
      Liu L, Wada H, Matsubara N, Hozumi K and Itoh M.
    • Journal Title

      J Cell Biochem

      Volume: 118 Pages: 785-796

    • DOI

      10.1002/jcb.25744

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-15H01161, KAKENHI-PROJECT-25670020
  • [Journal Article] Jagged1-induced Notch activation contributes to the acquisition of bortezomib resistance in myeloma cells2017

    • Author(s)
      Yukari Muguruma, Takashi Yahata, Takayuki Warita, Katsuyo Hozumi, Yoshihiko Nakamura, Rikio Suzuki, Mamoru Ito, Kiyoshi Ando
    • Journal Title

      Blood Cancer J.

      Volume: 7 Pages: 1007-1012

    • DOI

      10.1038/s41408-017-0001-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04287, KAKENHI-PROJECT-15H04301, KAKENHI-PROJECT-17H03572, KAKENHI-PROJECT-16K14635
  • [Journal Article] Jun Abe, Kiyoshi Higashi, Yutaka Inagaki, and Tetsuya Mine: Anti-fibrotic effects of a novel small compound on the regulation of cytokine production in a mouse model of colorectal fibrosis.2015

    • Author(s)
      Imai J, Hozumi K, Sumiyoshi H, Yazawa M, Hirano K, Abe J, Higashi K, Inagaki Y, Mine T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 468 Pages: 554-560

    • DOI

      10.1016/j.bbrc.2015.10.123

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10071, KAKENHI-PROJECT-15K15299, KAKENHI-PROJECT-25293179
  • [Journal Article] Delta-like 4-mediated Notch signaling is required for early T cell development in a three-dimensional thymic structure2015

    • Author(s)
      Hirano K, Negishi N, Yazawa M, Yagita H, Habu S, Hozumi K
    • Journal Title

      European Journal of Immunology

      Volume: 45 Pages: 2252-2262

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-15H01161
  • [Journal Article] Anti-fibrotic effects of a novel small compound on the regulation of cytokine production in a mouse model of colorectal fibrosis.2015

    • Author(s)
      Imai J, Hozumi K, Sumiyoshi H, Yazawa M, Hirano K, Abe J, Higashi K, Inagaki Y, Mine T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 468(4) Pages: 554-560

    • DOI

      10.1155/2016/2964581

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K19353
  • [Journal Article] Notch ligands transduce different magnitudes of signaling critical for determination of T-cell fate2011

    • Author(s)
      Abe N, Hozumi K, Hirano K, Yagita H and Habu S
    • Journal Title

      Eur. J. Immunol

      Volume: 40 Pages: 2608-2617

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390121
  • [Journal Article] Notch signaling is necessary for GATA3 function in the initiation of T cell development2008

    • Author(s)
      Hozumi K., et.al.
    • Journal Title

      European Journal of Immunology 38

      Pages: 977-985

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057026
  • [Journal Article] Expression of Delta-like 1 in the splenic non-hematopoietic cells is essential for marginal zone B cell development.2008

    • Author(s)
      Sheng, Y., Yahata, T., Negishi, N., Nakano, Y., Habu, S., Hozumi, K. and Ando, K.
    • Journal Title

      Immunol. Lett. 121

      Pages: 33-37

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390115
  • [Journal Article] Notch signaling is necessary for GATA3 function in the initiation of T cell development.2008

    • Author(s)
      Hozumi K., et al.
    • Journal Title

      European Journal of Immunology 38

      Pages: 977-985

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390115
  • [Journal Article] Notch signaling is necessary for GATA3 function in the initiation of T cell development.2008

    • Author(s)
      Hozumi, K., Negishi, N., Tsuchiya, I., Abe, N., Hirano, K., Suzuki, D., Yamamoto, M., Engel, J. D. and Habu, S.
    • Journal Title

      Eur. J. Immunol. 38

      Pages: 977-985

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390115
  • [Journal Article] Delta-like 4 is indispensable in thymic environment specific for T cell development.2008

    • Author(s)
      Hozumi K., et al.
    • Journal Title

      Journal of Experimental Medicine 205

      Pages: 2507-2513

    • NAID

      40016715345

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390115
  • [Journal Article] Delta-like 4 is indispensable in thymic environment spe cific for T cell development2008

    • Author(s)
      Hozumi K., et.al.
    • Journal Title

      Journal of Experimental Medicine 205

      Pages: 2507-2513

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20060024
  • [Journal Article] Delta-like 4 is indispensable in thymic environment specific for T cell development2008

    • Author(s)
      Hozumi K., et.al.
    • Journal Title

      Journal of Experimental Medicine 205

      Pages: 2507-2513

    • NAID

      40016715345

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057026
  • [Journal Article] Notch signaling is necessary for GATA3 function in the initiation of T cell development2008

    • Author(s)
      Hozumi K., et.al.
    • Journal Title

      European Journal of Immunology 38

      Pages: 977-985

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20060024
  • [Journal Article] Delta-like 4 is indispensable in thymic environment specific for T cell development.2008

    • Author(s)
      Hozumi, K., Mailhos, C., Negishi, N., Hirano, K., Yahata, T., Ando, K., Zuklys, S., Hollander, G. A., Shima, D. T. and Habu, S.
    • Journal Title

      J. Exp. Med. 205

      Pages: 2507-2513

    • NAID

      40016715345

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390115
  • [Journal Article] Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo.2007

    • Author(s)
      Oyama, T., Harigaya, K., Muradil, A., Hozumi, K., Habu, S., Iwama, A., Oguro, H., Matsuno, K., Sakamoto, R., Sato, M., Yoshida, N. and Kitagawa, M.
    • Journal Title

      Proc. Natl. Acad. Sci. USA. 104

      Pages: 9764-9769

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390115
  • [Journal Article] Jaggedl is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis.2006

    • Author(s)
      Estrach S, Ambler CA, Lo Celso C, Hozumi K, Watt FM
    • Journal Title

      Development 133

      Pages: 4427-4438

    • Data Source
      KAKENHI-PROJECT-18060040
  • [Journal Article] Notch ligands with contrasting functions : Jaggedi and Delral in the mouse inner ear.2006

    • Author(s)
      Brooker R, Hozumi K, Lewis J
    • Journal Title

      Development 133

      Pages: 1277-1286

    • Data Source
      KAKENHI-PROJECT-18060040
  • [Presentation] Dll1 and Dll4 differently require their extracellular domains for triggering Notch signaling in mice2020

    • Author(s)
      穂積勝人
    • Organizer
      日本分子生物学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K07330
  • [Presentation] The epigenetic regulation of gene loci encoding transcription factor critical for the determination of T/B-cell lineages by Lmo22018

    • Author(s)
      Hozumi K, Hirano KI
    • Organizer
      日本免疫学会
    • Data Source
      KAKENHI-PROJECT-16K08848
  • [Presentation] Molecular machinery for the maintenance of differentiation potential toward T/B cell lineages in hematopoietic stem/progenitor cells by Lmo22017

    • Author(s)
      Katsuto Hozumi, Shuhei Ochiai, Ken-ichi Hirano
    • Organizer
      日本免疫学会
    • Data Source
      KAKENHI-PROJECT-16K08848
  • [Presentation] Jagged1/Notchシグナルを介した線維肝再生における前駆細胞動員機構の解明.2017

    • Author(s)
      中野泰博、中尾祥絵、住吉秀明、三上健一郎、丹野友里、末岡 美那子 、笠原大瑚、木村 啓志、茂呂 忠、紙谷聡英、穂積勝人、稲垣 豊
    • Organizer
      第16回日本再生医療学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-09
    • Data Source
      KAKENHI-PROJECT-25293179
  • [Presentation] Molecular machinery for the maintenance of differentiation potential toward T/B cell lineages in hematopoietic stem/progenitor cells by Lmo22017

    • Author(s)
      Hozumi K、Ochiai S、Hirano K
    • Organizer
      日本免疫学会・学術集会
    • Data Source
      KAKENHI-PROJECT-16K14635
  • [Presentation] Dll4-mediated Notch1 signaling is required for the conversion from Treg to Tfh in Peyers patch.2016

    • Author(s)
      Yazawa M and Hozumi K
    • Organizer
      日本免疫学会・学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-05
    • Data Source
      KAKENHI-PUBLICLY-15H01161
  • [Presentation] Essential role of Lmo2 for the maintenance of T-cell differentiation potential in Ebf1-deficient pro-B cells.2016

    • Author(s)
      Hozumi K、Ochiai S、Hirano K
    • Organizer
      日本免疫学会・学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-05
    • Data Source
      KAKENHI-PROJECT-16K08848
  • [Presentation] Anti-fibrotic effects of a novel small compound that promotes the nuclear translocation of YB-1 in a mouse model of colorectal fibrosis.2016

    • Author(s)
      Imai J, Hozumi K, Inagaki Y, Mine T.
    • Organizer
      European Crohn's and Colitis Organisation 2016
    • Place of Presentation
      RAI Amsterdam (Netherlands)
    • Year and Date
      2016-03-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19353
  • [Presentation] Contribution of Jagged1/Notch signaling to murine fibrotic liver regeneration through possible dedifferentiation of mature hepatocytes.2016

    • Author(s)
      Yasuhiro Nakano, Sachie Nakao, Hideaki Sumiyoshi, Kenichiro Mikami, Yuri Tanno, Daigo Kasahara, Hiroshi Kimura, Tadashi Moro, Akihide Kamiya, Katsuto Hozumi, Yutaka Inagaki
    • Organizer
      67th Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      Hynes Convention Center (Boston, MA, U.S.A.)
    • Year and Date
      2016-11-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293179
  • [Presentation] YB-1の核内移行を促進させる小化合物を用いたクローン病腸管線維化モデルに対する抗線維化治療の検討2016

    • Author(s)
      今井 仁、峯 徹哉、稲垣 豊、穂積 勝人
    • Organizer
      第102回に本消化器病学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2016-04-21
    • Data Source
      KAKENHI-PROJECT-15K19353
  • [Presentation] Essential role of Lmo2 for the maintenance of T-cell differentiation potential in Ebf1-deficient pro-B cells2016

    • Author(s)
      Hozumi K、Ochiai S、Hirano K
    • Organizer
      日本免疫学会・学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-05
    • Data Source
      KAKENHI-PROJECT-16K14635
  • [Presentation] 肝発生および線維肝再生過程における肝前駆細胞は、間葉系細胞のJagged-1をリガンドとするNotchシグナルによって制御される.2016

    • Author(s)
      中野泰博、中尾祥絵、住吉秀明、三上健一郎、丹野友里、茂呂 忠、紙谷聡英、穂積勝人、稲垣 豊
    • Organizer
      第23回肝細胞研究会
    • Place of Presentation
      大阪大学中之島センター (大阪府大阪市)
    • Year and Date
      2016-07-07
    • Data Source
      KAKENHI-PROJECT-25293179
  • [Presentation] Contribution of Jagged1/Notch signaling to murine fibrotic liver regeneration through possible dedifferentiation of mature hepatocytes.2016

    • Author(s)
      Yasuhiro Nakano, Sachie Nakao, Hideaki Sumiyoshi, Kenichiro Mikami, Yuri Tanno, Minako Sueoka, Daigo Kasahara, Hiroshi Kimura, Tadashi Moro, Akihide Kamiya, Katsuto Hozumi, Yutaka Inagaki
    • Organizer
      9th Notch Meeting
    • Place of Presentation
      国立遺伝学研究所(静岡県三島市)
    • Year and Date
      2016-10-05
    • Data Source
      KAKENHI-PROJECT-25293179
  • [Presentation] Jagged1/Notchシグナルは線維肝再生における肝前駆細胞の動員に機能する.2016

    • Author(s)
      中野泰博、中尾祥絵、住吉秀明、三上健一郎、丹野友里、末岡 美那子 、笠原大瑚、木村啓志、茂呂 忠、紙谷聡英、穂積勝人、稲垣 豊
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-12-01
    • Data Source
      KAKENHI-PROJECT-25293179
  • [Presentation] The structure-function relationship in Dll1/Dll4 chimeric molecules for supporting T cell development2015

    • Author(s)
      Hozumi K, Ochiai, S, Hirano K
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      兵庫県神戸市・神戸コンベンションセンター
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PUBLICLY-15H01161
  • [Presentation] Kaori Minakawa, Katsuto Hozumi, Isao Okazaki, Shinsaku Fukuda, Yutaka Inagaki. Notch/Jagged-1 signal modulates pathophysiological correlation between fibrogenesis and regeneration in murine liver2011

    • Author(s)
      Kenichiro Mikami, Sachie Nakao, Reiichi Higashiyama, Hiroshi Fukumitsu, Tadashi Moro, Kaori Minakawa, Katsuto Hozumi, Isao Okazaki, Shinsaku Fukuda, Yutaka Inagaki
    • Organizer
      The 62^<nd> Annual Meeting of The American Association for the Study of Liver Disease
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2011-11-07
    • Data Source
      KAKENHI-PROJECT-23590991
  • [Presentation] Roles of Notch ligands : Delta-like 1 and Jagged1 in pancreas development2011

    • Author(s)
      Nakano Y, Hozumi K, et al.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-13
    • Data Source
      KAKENHI-PROJECT-21390121
  • [Presentation] Delta-like 4 has particular significance for T cell development in the thymus2010

    • Author(s)
      Hozumi K, et al.
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe、Japan
    • Year and Date
      2010-08-25
    • Data Source
      KAKENHI-PROJECT-21390121
  • [Presentation] Delta like 4 has particular significance for T cell development in the thymus.2010

    • Author(s)
      Hozumi K, et al.
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      神再国際展示場(兵庫県)
    • Year and Date
      2010-08-25
    • Data Source
      KAKENHI-PROJECT-21390121
  • [Presentation] Notch signals regulated hematopoietic homeostasis through osteoblastic niche maintenance.2010

    • Author(s)
      六車ゆかり、八幡崇、弓野静、盛音、穂積勝人、安藤潔
    • Organizer
      第72回日本血液学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PROJECT-20590289
  • [Presentation] 骨芽細胞におけるDelta-like ligand1の発現が骨代謝維持に重要である2010

    • Author(s)
      六車ゆかり、八幡崇、穂積勝人、安藤潔
    • Organizer
      第28回日本骨代謝学会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2010-07-22
    • Data Source
      KAKENHI-PROJECT-20590289
  • [Presentation] Physiological significance of Delta-like 4 for the DN/DP transition in the thymus2010

    • Author(s)
      Hirano K, Hozumi K, et al.
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe、Japan
    • Year and Date
      2010-08-25
    • Data Source
      KAKENHI-PROJECT-21390121
  • [Presentation] Delta-like 4 has particular significance for T cell development in the thymus.2010

    • Author(s)
      Hozumi K., et al.
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      神戸国際展示場(兵庫県)
    • Year and Date
      2010-08-25
    • Data Source
      KAKENHI-PUBLICLY-22021040
  • [Presentation] Delta-like 4 is indispensable in thymic environment specific for T cell development2009

    • Author(s)
      穂積勝人
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2009-12-09
    • Data Source
      KAKENHI-PROJECT-21390121
  • [Presentation] Delta-like 4 is indispensable in thymic environment specific for T cell development2009

    • Author(s)
      Hozumi K, et al.
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Data Source
      KAKENHI-PROJECT-21390121
  • [Presentation] The physiological significance of Notch ligands for pancreatic development2009

    • Author(s)
      Nakano Y, Hozumi K, et al.
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-10
    • Data Source
      KAKENHI-PROJECT-21390121
  • [Presentation] 胸腺内T細胞分化におけるDll4の生理的役割2009

    • Author(s)
      穂積勝人, 他
    • Organizer
      第39回日本免疫学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-02
    • Data Source
      KAKENHI-PROJECT-21390121
  • [Presentation] The physiological significance of Notch ligands for pancreas development2009

    • Author(s)
      中野泰博、穂積勝人
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2009-12-10
    • Data Source
      KAKENHI-PROJECT-20057026
  • [Presentation] 胸腺環境要因としてのD114の役割2008

    • Author(s)
      穂積勝人
    • Organizer
      第38回日本免疫学会総会学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2008-12-02
    • Data Source
      KAKENHI-PROJECT-19390115
  • [Presentation] 胸腺分化環境要因としてのNotchリガンド : D114の役割2008

    • Author(s)
      穂積勝人
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-11
    • Data Source
      KAKENHI-PROJECT-20057026
  • [Presentation] 胸腺分化環境要因としてのNotchリガンド:Dll4の役割2008

    • Author(s)
      穂積勝人
    • Organizer
      、第31回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Data Source
      KAKENHI-PROJECT-19390115
  • [Presentation] 胸腺環境要因としてのD114の役割2008

    • Author(s)
      穂積勝人
    • Organizer
      第38回日本免疫学会総会学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2008-12-02
    • Data Source
      KAKENHI-PROJECT-20060024
  • [Presentation] 胸腺環境要因としてのD114の役割2008

    • Author(s)
      穂積勝人
    • Organizer
      第38回日本免疫学会総会学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2008-12-02
    • Data Source
      KAKENHI-PROJECT-20057026
  • [Presentation] 胸腺分化環境要因としてのNotchリガンド : D114の役割2008

    • Author(s)
      穂積勝人
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-11
    • Data Source
      KAKENHI-PROJECT-20060024
  • [Presentation] 胸腺分化環境要因としてのDll4の役割2008

    • Author(s)
      穂積勝人
    • Organizer
      第38回日本免疫学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-02
    • Data Source
      KAKENHI-PROJECT-19390115
  • [Presentation] 胸腺分化環境要因としてのNotchリガンド : D114の役割2008

    • Author(s)
      穂積勝人
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-11
    • Data Source
      KAKENHI-PROJECT-19390115
  • [Presentation] Dll4 expressed on thymic epithelial cells is required for T cell development in the thymus.2007

    • Author(s)
      Hozumi, K., et. al.
    • Organizer
      日本免疫学会総会・学術集会
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Year and Date
      2007-11-21
    • Data Source
      KAKENHI-PROJECT-18060040
  • [Presentation] Dll4 expressed on thymic epithelial cells is required for T cell development in the thymus2007

    • Author(s)
      Hozumi, K., et al.
    • Organizer
      日本免疫学会総会・学術集会
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Year and Date
      2007-11-21
    • Data Source
      KAKENHI-PROJECT-19390115
  • [Presentation] Dll4 expressed on thymic epithelial cells s required for T cell development in the thymus.2007

    • Author(s)
      穂積勝人
    • Organizer
      シンポジウム、第37回日本免疫学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
    • Data Source
      KAKENHI-PROJECT-19390115
  • 1.  ANDO Kiyoshi (70176014)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 8 results
  • 2.  INAGAKI Yutaka (80193548)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 12 results
  • 3.  HABU Sonoko (30051618)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  佐藤 健人 (50235363)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  YAHATA Takashi (10398753)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 6.  MINE Tetsuya (20157572)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 7.  IMAI Kenji (70193646)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  NAKAYAMA Yukari (80398750)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 9.  ASAHARA Takayuki (20246200)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  MIKAMI KENICHIRO (00375263)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 11.  NISHIMURA Takashi (30143001)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  HIRAYAMA Noriaki (70238393)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  IMAI Jin (40725363)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 14.  KOTANI Ai (00517477)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  Masaharu Mori (00445389)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  紙谷 聡英 (30321904)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 17.  住吉 秀明 (60343357)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 18.  伊川 友活 (60450392)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  大塚 正人 (90372945)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  渡邉 稔彦 (50306734)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  清水 隆弘 (80626705)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  佐藤 慎二 (90276238)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  細野 祐司 (60868090)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  MORO Kazuyo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  細川 裕之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 26.  木村 啓志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  中野 泰博
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  長澤 丘司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  小安 重夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  伊藤 素行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  遠藤 裕介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  中村 雅登
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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