Kinoshita Taroh 木下タロウ

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KINOSHITA Taroh 木下タロウ

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Researcher Number	10153165
Other IDs
Affiliation (Current)	2023: 大阪大学, 微生物病研究所, 特任教授(常勤)
Affiliation (based on the past Project Information) *help	2022 – 2023: 大阪大学, 微生物病研究所, 特任教授(常勤) 2017 – 2021: 大阪大学, 微生物病研究所, 寄附研究部門教授 2016: 大阪大学, 微生物病研究所, 教授 1991 – 2013: 大阪大学, 微生物病研究所, 教授 1999 – 2000: 大阪大学, 微生物研究所, 教授 1988 – 1990: 大阪大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Structural biochemistry / Biological Sciences / 細菌学 / Parasitology (including Sanitary zoology) / Basic Section 43020:Structural biochemistry-related / Structural biochemistry / Functional biochemistry Except Principal Investigator 細菌学 / Hematology / Biological Sciences … More / Functional biochemistry / Immunology / 蚕糸学 / Pathological medical chemistry Less
Keywords	Principal Investigator GPIアンカー / 小胞体 / 糖転移酵素 / 補体 / 糖鎖遺伝子 / 発作性夜間血色素尿症 / endoplasmic reticulum / GPI anchor / 翻訳後修飾 / Complement … More / 糖鎖 / 造血幹細胞 / 生合成 / 糖脂質 / biosynthesis / 生合成経路 / Glycogenes / GPI Anchor / Self defense / 生体防御 / 酵素 / 遺伝子 / 脂肪酸 / シアル酸 / 睡眠病 / トリパノソーマ / 原虫 / 遺伝子クローニング / 遺伝子病 / X染色体 / 体細胞突然変異 / グリコシルホスファチジルイノシトール / sialic acid / protozoa / Trypanosoma brucei / sleeping sickness / glycosylphosphatidylinositol / 睡眠病トリパノソーマ / N結合型糖質 / 脂質 / 細胞・組織 / gene cloning / glycolipid / post trarnslational modification / 塘脂質 / post translational modification / GIPアンカー / glycosyltransferase / post-translational modification / Endoplasmic reticulum / Glycosyltransferases / 糖転位酵素 / Paroxysmal Nocturnal Hemoglobinuria / Genetic Disease / Hematopoietic Stem Cell / Somatic Mutation / X-chromosome / ×染色体 / Complement receptor / 補体レセプタ- / 補体レセプター / Immunity / 免疫 / 糖質 / タンパク質 / トランスシアリダーゼ / PIG-A遺伝子 / ノックアウトマウス / 再生不良性貧血 / モデル動物 / ジーンターゲティング / マラリア … More Except Principal Investigator GPIアンカー / GPI / PNH / 糖転移酵素 / 糖鎖 / Ras / HMGA2 / Fas / NMR / RAPD / C5a / 発作性夜間ヘモグロビン尿症 / リモデリング / ラフト / 輸送 / 糖タンパク質 / 糖脂質 / サイトカイン / 免疫病 / 蛋白毒素 / LPS / 極性輸送 / TGN / リサイクリングエンドソーム / 電子顕微鏡 / ゾーン / 電顕トモグラフィー / ノックアウトマウス / Rab / GPIアンカータンパク / 細胞極性 / GPI修飾酵素 / 上皮細胞 / ゴルジ体 / 選別輸送 / ビタミンB1 / ビタミンB6 / PIGA / clonal expansion / GPI アンカー / ビタミンB６ / ビタミンB１ / アルカリホスファターゼ / Escherichia coli / C9-deficient serum / Bactericidal activity / 膜傷害 / 免疫殺菌反応 / 大腸菌 / 免疫殺菌作用 / C9欠損血清 / regulation of expression / carbohydrate / signal transduction / cells and tissues / genes / 発現制御 / シグナル伝達 / 細胞・組織 / 遺伝子 / Eri1p / Eri1 / RhoA / PIG-Y / Erilp / raft / de-acylation / remodeling / transport / GPI-anchor / 脱アシル化 / bioreyulation / Knolout / signal / proteoglycan / glycolinid / glycoprotein / glycosyltransferase / glycosylation / 機能調節 / ミクロドメイン / 分子複合体 / グライコミクス / ノックアウト / シグナル / プロテオグリカン / 細胞膜 / 生体調節 / immune proteasome / NK cell / cytokine receptors / antigen receptors / autoimmune disease / collaborative research / molecular basis of immune disease / 免疫寛容 / 細胞死 / 情報伝達 / B,T細胞分化 / 免疫異常 / 自己免疫病 / 免疫プロテアソーム / NK細胞 / サイトカイン受容体 / 抗原受容体 / 自己抗原病 / 共同研究 / 免疫病の分子基盤 / Biosensor / Protein interaction / Gene targeting / Higher plants / Morphogenesis / Cre-loxP / Fission yeast / 植物 / 胚形成 / 蛋白高次機能構造 / 遺伝子ターゲティング / RNAプロセシング / バイオモニタリング / DNA再複製 / 細胞周期 / 温度感受性突然変異体 / ATPase / 免疫系 / バイオセンサー / 分子相互作用 / 遺伝子標的 / 高等植物 / 形態形成 / Cre-IoxP / 分裂酵母 / Bombyx mori / Mutation / Linkage map / Neuropeptide / Genome / Chromosome / Lethal gene / エクダイソン / PCR / ホメオティック遺伝子 / 前胸腺 / 家蚕 / 遺伝的モザイク / ゲノム解析 / ペプチドホルモン / 休眠 / 胚子発生 / カイコ / 突然変異 / 連関地図 / 神経ペプチド / ゲノム / 染色体 / 致死遺伝子 / Cytotoxic toxins / Exotoxin / Lipopolysaccharide / Endotoxin / Bacterial toxins / 細胞傷害 / 細胞毒 / 外毒素 / リポ多糖 / 内毒素 / 細菌毒素 / Epitope / Monoclonal antibody / Chemotactic activity / Complement / エピト-プマッピッグ / モノクロ-ナル抗体 / 補体活性化フラグメントC5a / エピトープ / モノクローナル抗体 / 走化活性 / 補体 / traT gene of R factor / Staphylococcal M Protein / Bactericidal Activity / Phagocytosis / Serum-resistant Bacteria / 食菌作用 / 補体抵抗性 / R因子tra T遺伝子 / 貧食作用 / 補体抵抗菌 / R因子TraT遺伝子 / レンサ球菌M蛋白 / 殺菌作用 / 貪食作用 / 補体抵抗性菌 / GPIアンカー型蛋白質 / 精神発達遅滞 / 深部静脈血栓症 / 溶血性貧血 / 補体制御因子 / 高アルカリホスファターゼ血症 / 高アルカリフォスファターゼ血症 / 精神運動発達障害 / てんかん / 先天性GPI欠損症 / 糖鎖遺伝子 / 糖鎖リモデリング / 複合糖質 / ヒトヘルペスウイルス / CD40 / ヒトヘルペルウイルス6 / インターロイキン6 / 粘膜免疫 / Toll様レセプター / セマフォリン / ヒトヘルペスウイルス6 / 自然免疫 / 感染症 / LANA / gH-gL-gO / MyD88非依存症性経路 / TLR / sema6D / Sema4A / PIG-V / マクロファージ / 宿主細胞因子 / 感染 / 情報モジュレイション / 生体細胞情報 Less

グリコシルホスファチジルイノシトール (GPI) 生合成の制御メカニズムの解明Principal Investigator
- Principal Investigator
  
  木下タロウ
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Osaka University
上皮細胞の極性輸送における細胞小器官内選別輸送ゾーンの有無とその意義
- Principal Investigator
  
  原田彰宏
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Physiological and pathological roles of GPI side chains and free GPIPrincipal Investigator
- Principal Investigator
  
  Kinoshita Taroh
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
Analysos of metabolic abnormality which causes clonal expansion in Paroxysmal nocturnal hemoglobinuria
- Principal Investigator
  
  Murakami Yoshiko
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Osaka University
Analysis for the molecular mechanism of Inheited GPI Deficiency
- Principal Investigator
  
  MURAKAMI Yoshiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka University
Molecular mechanisms and functions of structural changes of protein GPI-anchorsPrincipal Investigator
- Principal Investigator
  
  KINOSHITA Taroh
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka University
Stage specific modifications of GPI anchor in Trypanosoma bruceiPrincipal Investigator
- Principal Investigator
  
  KINOSHITA Taroh
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Parasitology (including Sanitary zoology)
- Research Institution
  Osaka University
Investigation of the mechanism for clonal expansion of GPI negative cells in paroxysmal nocturnal hemoglobinuria
- Principal Investigator
  
  MURAKAMI Yoshiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
Biosynthesis and functions of GPI-anchored proteins in African trypanosomesPrincipal Investigator
- Principal Investigator
  
  KINOSHITA Taroh
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Parasitology (including Sanitary zoology)
- Research Institution
  OSAKA UNIVERSITY
GPIアンカー型蛋白質の輸送機構の解明:ラフトヘのアプローチとして
- Principal Investigator
  
  MAEDA Yusuke
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
The regulation of functions and expressions of proteins by glycosylphosphatidylinositol-anchor
- Principal Investigator
  
  MAEDA Yusuke
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka University
Investigation into the mechanism for expansion of abnormal clone in paroxysmal nocturnal hemoglobinuria
- Principal Investigator
  
  MURAKAMI Yoshiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
Function regulation of proteins and molecular complexes with glycosylation.
- Principal Investigator
  
  FURUKAWA Koichi
- Project Period (FY)
  2002 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
GPIアンカー合成の調節機構と合成不全症Principal Investigator
- Principal Investigator
  
  木下タロウ
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Biosynthesis pathway of GPI anchored proteins.Principal Investigator
- Principal Investigator
  
  KINOSHITA Taroh
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
Mechanism of biosynthesis of protein GPI anchors.Principal Investigator
- Principal Investigator
  
  KINOSHITA Taroh
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Structural biochemistry
- Research Institution
  OSAKA UNIVERSITY
糖鎖遺伝子による細胞リモデリング
- Principal Investigator
  
  谷口直之
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Osaka University
Molecular basis for immunological disease
- Principal Investigator
  
  WATANABE Takeshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Immunology
- Research Institution
  KYUSHU UNIVERSITY
発作性夜間血色素尿症の分子病態学Principal Investigator
- Principal Investigator
  
  木下タロウ
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
感染症と免疫病の分子生物学と医学
- Principal Investigator
  
  山西弘一, KISHIMOTO Tadamitsu
- Project Period (FY)
  1997 – 2003
- Research Category
  
  Grant-in-Aid for COE Research
- Research Institution
  Osaka University
Molecular mechanism of GPI anchir biosynthesisPrincipal Investigator
- Principal Investigator
  
  KINOSHITA Taroh
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
アラリアGPI アンカーの生合成遺伝子群のクローニングPrincipal Investigator
- Principal Investigator
  
  木下タロウ
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
発作性夜間血色素尿症の分子病態Principal Investigator
- Principal Investigator
  
  木下タロウ
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Characterization of GPI anchor biosynthesis genes.Principal Investigator
- Principal Investigator
  
  KINOSHITA Taroh
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
発作性夜間血色素尿症(PNH)の病因研究Principal Investigator
- Principal Investigator
  
  木下タロウ
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Osaka University
Regulation of Gene Expression
- Principal Investigator
  
  TANIGUCHI Masaru
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Chiba University
Cloning of a GPI-anchor synthsis gene, PIG-A and characterization of its clinical significanecePrincipal Investigator
- Principal Investigator
  
  KINOSHITA Taroh
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
補体の起炎反応を活用した抗腫瘍免疫誘導法の研究
- Principal Investigator
  
  岡田秀親
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagoya City University
微生物由来物質による生体細胞情報のモジュレイション
- Principal Investigator
  
  TAKEDA Yoshifumi
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  細菌学
- Research Institution
  Kyoto University
Molecular mechanisms of bacterial toxins on host cells
- Principal Investigator
  
  NAKANO Masayasu
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  細菌学
- Research Institution
  Jichi Medical School
Studies on the genes controlling lethality and development of the silkmoth, Bombyx mori.
- Principal Investigator
  
  KOBAYASHI Masahiko
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  蚕糸学
- Research Institution
  The University of Tokyo
Structure and function of chemotactic factor, C5a, and its receptor
- Principal Investigator
  
  TAKEDA Junji
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  Osaka University
Roles of complement and complement receptor in self defensePrincipal Investigator
- Principal Investigator
  
  KINOSHITA Taroh
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  Osaka University
Analysis of Resistance Mechanism of Complement-resistant Bacteria
- Principal Investigator
  
  INOUE Kozo
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  細菌学
- Research Institution
  Osaka University
Structural and Functional Analysis of Complement C3/C5 Convertases.Principal Investigator
- Principal Investigator
  
  KINOSHITA Taroh
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  Osaka University
Analysis of immune bactericidal reaction by human complement component C9-deficient serum
- Principal Investigator
  
  KYONGSU Hong
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  Osaka University

[Book] Essentials of Glycobiology、Third edition2017
- Author(s)
  Varki, A., Cummings, R.D., Esko, J.D., Stanley, P., Hart, G.W., Aebi, M., Darvill, A., Kinoshita, T., Packer, N.J., Prestegard, J., Schnaar, R., Seeberger, P.
- Total Pages
  823
- Publisher
  Cold Spring Harbor Laboratory Press
- ISBN
  9781621821328
- Data Source
  KAKENHI-PLANNED-17H06422
[Book] Overview of GPI biosynthesis. In The Enzymes, Vol. 262009
- Author(s)
  Taroh Kinoshita, M. Fujita, Eds. Menon, A. K., Kinoshita, T., Orlean, P., Tamanoi, F
- Publisher
  Academic Press
- Data Source
  KAKENHI-PROJECT-21247018
[Book] In Essentials of Glycobiology, 2nd ed. Ed. Varki, A. ; Cummings, R.D. ; Esko, J.D. ; Freeze, H.H. ; Stanley, P. ; Bertozzi, C.R. ; Hart, G.W. ; Etzler, M.E., Cold Spring Harbor Laboratory Press2008
- Author(s)
  Ferguson, M., T.Kinoshita and G.Hart
- Publisher
  Glycosylphosphatidylinositol anchors
- Data Source
  KAKENHI-PROJECT-19390119
[Book] Annual Review 血液 2008 先天性と後天性GPI欠損症2008
- Author(s)
  村上良子、木下タロウ
- Publisher
  中外医学者
- Data Source
  KAKENHI-PROJECT-18591060
[Book] 先天性GPI欠損症分子細胞治療 vol.7 no.12008
- Author(s)
  村上良子、木下タロウ
- Publisher
  先端医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591060
[Book] 先天性と後天性GPI欠損症 Annual Review 血液2008
- Author(s)
  村上良子、木下タロウ
- Publisher
  中外医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591060
[Book] Diseases associated with GPI anchors. In Comprehensive Glycoscience.2007
- Author(s)
  Kinoshita, T., Y. Murakami and Y. S. Morita.
- Publisher
  Elsevier Ltd. , Amsterdam.
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591060
[Book] 発作性夜間血色素尿症を代表とするGPI病、実験医学増刊糖鎖研究 vol.25 No.72007
- Author(s)
  村上良子、木下タロウ
- Publisher
  羊土社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591060
[Book] 実験医学糖鎖研究発作性夜間血色素尿症を代表とするGPI病2007
- Author(s)
  村上良子、木下タロウ
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-18591060
[Journal Article] Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradation2020
- Author(s)
  Wang Yicheng、Maeda Yusuke、Liu Yi-Shi、Takada Yoko、Ninomiya Akinori、Hirata Tetsuya、Fujita Morihisa、Murakami Yoshiko、Kinoshita Taroh
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 860-860
- DOI
  10.1038/s41467-020-14678-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04753
[Journal Article] Paroxysmal nocturnal hemoglobinuria caused by CN-LOH of constitutional PIGB mutation and 70-kb microdeletion on 15q.2020
- Author(s)
  Langemeijer, S., C. Schaap, F. Preijers, J. H. Jansen, N. Blijlevens, N. Inoue, P. Muus, T. Kinoshita and Y. Murakami.
- Journal Title
  
  Blood Adv.
  
  Volume: 4 Pages: 5755-5761
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06422
[Journal Article] PGAP6, a GPI-specific phospholipase A2, has narrow substrate specificity against GPI-anchored proteins2020
- Author(s)
  Lee Gun-Hee、Fujita Morihisa、Nakanishi Hideki、Miyata Haruhiko、Ikawa Masahito、Maeda Yusuke、Murakami Yoshiko、Kinoshita Taroh
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 42 Pages: 14501-14509
- DOI
  10.1074/jbc.ra120.014643
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04753, KAKENHI-PLANNED-17H06422
[Journal Article] α2,3 linkage of sialic acid to a GPI anchor and an unpredicted GPI attachment site in human prion protein2020
- Author(s)
  Kobayashi Atsushi、Hirata Tetsuya、Nishikaze Takashi、Ninomiya Akinori、Maki Yuta、Takada Yoko、Kitamoto Tetsuyuki、Kinoshita Taroh
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 22 Pages: 7789-7798
- DOI
  10.1074/jbc.ra120.013444
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-16H04753, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-19K22588, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06422
[Journal Article] Calnexin mediates the maturation of GPI-anchors through ER retention2020
- Author(s)
  Guo Xin-Yu、Liu Yi-Shi、Gao Xiao-Dong、Kinoshita Taroh、Fujita Morihisa
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 48 Pages: 16393-16410
- DOI
  10.1074/jbc.ra120.015577
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04753, KAKENHI-PLANNED-17H06422
[Journal Article] A post glycosylphosphatidylinositol (GPI) attachment to proteins, type 2 (PGAP2) variant identified in Mabry syndrome index cases: molecular genetics of the prototypical inherited GPI disorder.2020
- Author(s)
  Thompson, M., A. Knaus, A. Caliebe, H. Muhle, M. Nguyen, N. Baratang, T. Kinoshita, M. Percy, P. Campeau, Y. Murakami, P. Krawitz, D. Cole, and C. Mabry.
- Journal Title
  
  Eur. J. Med. Genet
  
  Volume: 63 Issue: 4 Pages: 103822-103822
- DOI
  10.1016/j.ejmg.2019.103822
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06422
[Journal Article] Bi-allelic Variants in the GPI Transamidase Subunit PIGK Cause a Neurodevelopmental Syndrome with Hypotonia, Cerebellar Atrophy, and Epilepsy2020
- Author(s)
  Nguyen Thi Tuyet Mai、Murakami Yoshiko、Mobilio Sabrina、Rosenfeld Jill A.、St-Denis Anik、Elrick Matthew J.、Anselm Irina、Rodan Lance H.、Tartaglia Marco、Gleeson Joseph、Kinoshita Taroh、Campeau Philippe M.
- Journal Title
  
  The American Journal of Human Genetics
  
  Volume: 106 Issue: 4 Pages: 484-495
- DOI
  10.1016/j.ajhg.2020.03.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04753, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06422
[Journal Article] Complement and inflammasome overactivation mediates paroxysmal nocturnal hemoglobinuria with autoinflammation.2019
- Author(s)
  Hochsmann B, Murakami Y, Osato M, Knaus A, Kawamoto M, Inoue N, Hirata T, Murata S, Anliker M, Eggermann T, Jager M, Floettmann R, Hollein A, Murase S, Ueda Y, Nishimura JI, Kanakura Y, Kohara N, Schrezenmeier H, Krawitz PM, Kinoshita T.
- Journal Title
  
  The Journal of Clinical Investigation
  
  Volume: 129 Issue: 12 Pages: 5123-5136
- DOI
  10.1172/jci123501
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08862, KAKENHI-PROJECT-16H04753, KAKENHI-PROJECT-19H03529, KAKENHI-PROJECT-19K08864, KAKENHI-PROJECT-18K16097, KAKENHI-PLANNED-17H06422
[Journal Article] Free, unlinked glycosylphosphatidylinositols on mammalian cell surfaces revisited2019
- Author(s)
  Wang Yicheng、Hirata Tetsuya、Maeda Yusuke、Murakami Yoshiko、Fujita Morihisa、Kinoshita Taroh
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 13 Pages: 5038-5049
- DOI
  10.1074/jbc.ra119.007472
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06422, KAKENHI-PROJECT-16H04753
[Journal Article] Mutations in PIGB Cause an Inherited GPI Biosynthesis Defect with an Axonal Neuropathy and Metabolic Abnormality in Severe Cases2019
- Author(s)
  Murakami Yoshiko, et al., Matsumoto Naomichi, et al., Campeau Philippe M.
- Journal Title
  
  The American Journal of Human Genetics
  
  Volume: 105 Issue: 2 Pages: 384-394
- DOI
  10.1016/j.ajhg.2019.05.019
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01539, KAKENHI-PROJECT-16H04753, KAKENHI-PROJECT-17K10080, KAKENHI-PLANNED-17H06422
[Journal Article] Mutations in PIGU Impair the Function of the GPI Transamidase Complex, Causing Severe Intellectual Disability, Epilepsy, and Brain Anomalies2019
- Author(s)
  Knaus Alexej、Kort?m Fanny、Kleefstra Tjitske、Stray-Pedersen Asbj?rg、?uki? Dejan、Murakami Yoshiko、Gerstner Thorsten、van Bokhoven Hans、Iqbal Zafar、Horn Denise、Kinoshita Taroh、Hempel Maja、Krawitz Peter M.
- Journal Title
  
  The American Journal of Human Genetics
  
  Volume: 105 Issue: 2 Pages: 395-402
- DOI
  10.1016/j.ajhg.2019.06.009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04753, KAKENHI-PLANNED-17H06422
[Journal Article] Cerebellar Neurodegeneration and Neuronal Circuit Remodeling in Golgi pH Regulator-Deficient Mice2019
- Author(s)
  Sou Yu-shin、Kakuta Soichiro、Kamikubo Yuji、Niisato Kazue、Sakurai Takashi、Parajuli Laxmi Kumar、Tanida Isei、Saito Hiromitsu、Suzuki Noboru、Sakimura Kenji、Maeda Yusuke、Kinoshita Taroh、Uchiyama Yasuo、Koike Masato
- Journal Title
  
  eNeuro
  
  Volume: 6 Issue: 3 Pages: 0427-18
- DOI
  10.1523/eneuro.0427-18.2019
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09040, KAKENHI-PROJECT-19K07276, KAKENHI-PROJECT-18K14842, KAKENHI-PROJECT-16H04667, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-17K15550, KAKENHI-PLANNED-17H06422
[Journal Article] Recurrent aseptic meningitis with PIGT mutations: a novel pathogenesis of recurrent meningitis successfully treated by eculizumab2018
- Author(s)
  Kawamoto Michi、Murakami Yoshiko、Kinoshita Taroh、Kohara Nobuo
- Journal Title
  
  BMJ Case Reports
  
  Volume: 1 Pages: bcr-2018-225910
- DOI
  10.1136/bcr-2018-225910
- Data Source
  KAKENHI-PLANNED-17H06422
[Journal Article] Mutations in PIGS, Encoding a GPI Transamidase, Cause a Neurological Syndrome Ranging from Fetal Akinesia to Epileptic Encephalopathy2018
- Author(s)
  Nguyen Thi Tuyet M、Murakami Y、Wigby Kristen M.、Baratang Nissan V.、Rousseau J、St-Denis A、Rosenfeld Jill A.、Laniewski Stephanie C.、Jones J、Iglesias Alejandro D.、Jones Marilyn C.、Masser-Frye D、Scheuerle Angela E.、Perry Denise L.、Taft Ryan J.、Le Deist F、Thompson M、Kinoshita T、Campeau Philippe M.
- Journal Title
  
  The American Journal of Human Genetics
  
  Volume: 103 Issue: 4 Pages: 602-611
- DOI
  10.1016/j.ajhg.2018.08.014
- Data Source
  KAKENHI-PLANNED-17H06422
[Journal Article] Nuclear envelope localization of PIG-B is essential for GPI-anchor synthesis in Drosophila2018
- Author(s)
  Yamamoto-Hino Miki、Katsumata Eri、Suzuki Emiko、Maeda Yusuke、Kinoshita Taroh、Goto Satoshi
- Journal Title
  
  Journal of Cell Science
  
  Volume: 131 Pages: 1-12
- DOI
  10.1242/jcs.218024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06421, KAKENHI-PLANNED-17H06422
[Journal Article] Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain2018
- Author(s)
  Hirata Tetsuya、Mishra Sushil K.、Nakamura Shota、Saito Kazunobu、Motooka Daisuke、Takada Yoko、Kanzawa Noriyuki、Murakami Yoshiko、Maeda Yusuke、Fujita Morihisa、Yamaguchi Yoshiki、Kinoshita Taroh
- Journal Title
  
  Nature Coomunications
  
  Volume: 9 Issue: 1 Pages: 405-405
- DOI
  10.1038/s41467-017-02799-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04753, KAKENHI-PLANNED-17H06422, KAKENHI-PROJECT-16H04758
[Journal Article] Lipid moiety of glycosylphosphatidylinositol-anchored proteins contributes to the determination of their final destination in yeast2018
- Author(s)
  Yoko-o Takehiko、Umemura Mariko、Komatsuzaki Akiko、Ikeda Kazutaka、Ichikawa Daisuke、Takase Kumiko、Kanzawa Noriyuki、Saito Kazunobu、Kinoshita Taroh、Taguchi Ryo、Jigami Yoshifumi
- Journal Title
  
  Genes to Cells
  
  Volume: 23 Issue: 10 Pages: 880-892
- DOI
  10.1111/gtc.12636
- Data Source
  KAKENHI-PLANNED-17H06422
[Journal Article] Early infancy-onset stimulation-induced myoclonic seizures in three siblings with inherited glycosylphosphatidylinositol (GPI) anchor deficiency.2018
- Author(s)
  Mogami, Y., Y. Suzuki, Y. Murakami, T. Ikeda, S. Kimura, K. Yanagihara, N. Okamoto and T. Kinoshita.
- Journal Title
  
  Epileptic Disord
  
  Volume: 20 Issue: 1 Pages: 42-50
- DOI
  10.1684/epd.2018.0956
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06422
[Journal Article] Epileptic apnea in a patient with inherited glycosylphosphatidylinositol anchor deficiency and PIGT mutations.2018
- Author(s)
  Kohashi K, Ishiyama A*, Yuasa S, Tanaka T, Miya K, Adachi Y, Sato N, Saitsu H, Ohba C, Matsumoto N, Murakami Y, Kinoshita T, Sugai K, Sasaki M.
- Journal Title
  
  Brain Dev
  
  Volume: 40(1) Issue: 1 Pages: 53-57
- DOI
  10.1016/j.braindev.2017.06.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01539, KAKENHI-PROJECT-16H05160, KAKENHI-PLANNED-17H06422
[Journal Article] Congenital Defects in the Expression of the Glycosylphosphatidylinositol-Anchored Complement Regulatory Proteins CD59 and Decay-Accelerating Factor2018
- Author(s)
  Kinoshita Taroh
- Journal Title
  
  Seminars in Hematology
  
  Volume: 55 Issue: 3 Pages: 136-140
- DOI
  10.1053/j.seminhematol.2018.04.004
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06422, KAKENHI-PROJECT-16H04753
[Journal Article] N-Glycan dependent protein folding and endoplasmic reticulum retention regulate GPI-anchor processing.2017
- Author(s)
  Liu, Y.-S., X.-Y. Guo, T. Hirata, Y. Rong, D. Motooka, T. Kitajima, Y. Murakami, X.-D. Gao, S. Nakamura, T. Kinoshita* and M. Fujita*.
- Journal Title
  
  J. Cell Biol.
  
  Volume: 217 Issue: 2 Pages: 585-599
- DOI
  10.1083/jcb.201706135
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06422
[Journal Article] Glycosylphosphatidylinositol (GPI) anchor deficiency caused by mutations in PIGW is associated with West syndrome and hyperphosphatasia with mental retardation syndrome.2014
- Author(s)
  Chiyonobu T, Inoue N, Morimoto M, Kinoshita T, and Murakami Y.
- Journal Title
  
  J Med Genet.
  
  Volume: 51 Issue: 3 Pages: 203-207
- DOI
  10.1136/jmedgenet-2013-102156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590363, KAKENHI-PROJECT-24501336, KAKENHI-PUBLICLY-25129705
[Journal Article] Mutations in PGAP3 impair GPI-anchor maturation and lead to intellectual disability with hyperphosphatasia and additional phenotypic features.2014
- Author(s)
  Howard MF* Murakami Y* Pagnamenta AT, Haas CD, Fischer B, Hecht J, Keays DA, Knight SJL, Kolsch U, Kruger U, Leiz S, Maeda Y, Mitchell D, Mundlos S, Philipps JA, Robinson PN, Kini U, Taylor JC, Horn D, Kinoshita T, and Krawitz PM. （*equally contribution)
- Journal Title
  
  Am J Hum Genet
  
  Volume: 94 Issue: 2 Pages: 278-287
- DOI
  10.1016/j.ajhg.2013.12.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590363, KAKENHI-PUBLICLY-25129705
[Journal Article] Case report with vitamin B6 responsive epilepsy due to inherited GPI deficiency.2013
- Author(s)
  Kuki, I., Y. Takahashi, Okazaki, Ebara, N. Inoue, T. Kinoshita and Y. Murakami.
- Journal Title
  
  Neurology
  
  Volume: 81 Issue: 16 Pages: 1467-1469
- DOI
  10.1212/wnl.0b013e3182a8411a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590363, KAKENHI-PROJECT-24501336, KAKENHI-PUBLICLY-25129705
[Journal Article] Glycosylphosphatidylinositol mannosyltransferase II is the rate-limiting enzyme in glycosylphosphatidylinositol biosynthesis under limited dolichol-phosphate mannose availability2013
- Author(s)
  Hirata, T., M. Fujita, N. Kanzawa, Y. Murakami, Y. Maeda and T. Kinoshita
- Journal Title
  
  J. Bio chem
  
  Volume: 154 Issue: 3 Pages: 257-264
- DOI
  10.1093/jb/mvt045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247018, KAKENHI-PROJECT-23687017, KAKENHI-PROJECT-25860238
[Journal Article] Hypomorphic Mutations in PGAP2, Encoding a GPI-Anchor-Remodeling Protein, Cause Autosomal-Recessive Intellectual Disability2013
- Author(s)
  Hansen, L. Tawamie, H. Murakami, Y. Mang, Y. Ur Rehman, S. Buchert, R. Schaffer, S. Muhammad, S. Bak, M. Nothen, M. M. Bennett, E. P. Maeda, Y. Aigner, M. Reis, A. Kinoshita, T. et al.
- Journal Title
  
  Am J Hum Genet
  
  Volume: 92(4) Issue: 4 Pages: 575-583
- DOI
  10.1016/j.ajhg.2013.03.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590363, KAKENHI-PUBLICLY-25129705
[Journal Article] A case of paroxysmal nocturnal hemoglobinuria (PNH) caused by a germline mutation and a somatic mutation in PIGT2013
- Author(s)
  Krawitz, P. M., B. Hochsmann, Y. Murakami, B. Teubner, U. Kruger, E. Klopocki, H. Neitzel, A. Hollein, D. Parkhomchuk, J. Hecht, P. N. Robinson, S. Mundlos, T. Kinoshita and H. Schrezenmeier
- Journal Title
  
  Blood
  
  Volume: 122 Issue: 7 Pages: 1312-1315
- DOI
  10.1182/blood-2013-01-481499
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247018, KAKENHI-PROJECT-23590363
[Journal Article] PGAP2 Mutations, Affecting the GPI-Anchor-Synthesis Pathway, Cause Hyperphosphatasia with Mental Retardation Syndrome2013
- Author(s)
  Krawitz, P. M. Murakami, Y. Riess, A. Hietala, M. Kruger, U. Zhu, N. Kinoshita, T. Mundlos, S. Hecht, J. Robinson, P. N. Horn, D.
- Journal Title
  
  Am J Hum Genet
  
  Volume: 92(4) Issue: 4 Pages: 584-589
- DOI
  10.1016/j.ajhg.2013.03.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590363, KAKENHI-PUBLICLY-25129705
[Journal Article] Significance of GPI-anchored protein enrichment in lipid rafts for the control of autoimmunity2013
- Author(s)
  Wang, Y., Y. Murakami, T. Yasui, S. Wakana, H. Kikutani, T. Kinoshita and Y. Maeda
- Journal Title
  
  J. Biol. Chem
  
  Volume: 288 Issue: 35 Pages: 25490-25499
- DOI
  10.1074/jbc.m113.492611
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247018, KAKENHI-PROJECT-23370060, KAKENHI-PROJECT-24590550
[Journal Article] Transport of glycosylphosphatidylinositol-anchored proteins from the endoplasmic reticulum2013
- Author(s)
  Kinoshita, T., Y. Maeda and M. Fujita
- Journal Title
  
  Biochim. Biophys. Acta - Mol. Cell Res
  
  Volume: 1833 Issue: 11 Pages: 2473-2478
- DOI
  10.1016/j.bbamcr.2013.01.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247018, KAKENHI-PROJECT-23687017
[Journal Article] Occupancy of whole blood cells by a single PIGA-mutant clone with HMGA2 amplification in a paroxysmal nocturnal haemoglobinuria patient having blood cells with NKG2D ligands2013
- Author(s)
  Hanaoka, N., Y. Murakami, M. Nagata, K. Horikawa, S. Nagakura, Y. Yonemura, S. Murata, T. Sonoki, T. Kinoshita, H. Nakakuma
- Journal Title
  
  Br. J. Haematol.
  
  Volume: 160 Issue: 1 Pages: 114-116
- DOI
  10.1111/bjh.12093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590363, KAKENHI-PROJECT-23791087
[Journal Article] Deregulated expression of HMGA2 is implicated in clonal expansion of PIGA deficient cells in paroxysmal nocturnal haemoglobinuria.2012
- Author(s)
  Murakami Y, Inoue N, Shichishima T, Ohta R, Noji H, Maeda Y, Nishimura J, Kanakura Y, Kinoshita T.
- Journal Title
  
  Br J Haematol.
  
  Volume: 156 Pages: 383-387
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590363
[Journal Article] GPI anchors regulate glycosphingolipid levels2012
- Author(s)
  Loizides-Mangold, U., F. P. A. David, V. J. Nesatyy, T. Kinoshita and H. Riezman
- Journal Title
  
  J. Lipid Res
  
  Volume: 53 Issue: 8 Pages: 1522-1534
- DOI
  10.1194/jlr.m025692
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247018
[Journal Article] Deregulated expression of HMGA2 is implicated in clonal expansion of PIGA deficient cells in paroxysmal nocturnal haemoglobinuria2012
- Author(s)
  Murakami, Y., N. Inoue, T. Shichishima, R. Ohta, H. Noji, Y. Maeda, J. Nishimura, Y. Kanakura and T. Kinoshita
- Journal Title
  
  Br. J. Haematol
  
  Volume: 156 Issue: 3 Pages: 383-387
- DOI
  10.1111/j.1365-2141.2011.08914.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247018, KAKENHI-PROJECT-21590326, KAKENHI-PROJECT-22390194, KAKENHI-PROJECT-22591044, KAKENHI-PROJECT-22591067, KAKENHI-PROJECT-22791813, KAKENHI-PROJECT-23590363
[Journal Article] Mutations in PIGO, a member of the GPI anchor synthesis pathway, cause hyperphosphatasia with mental retardation2012
- Author(s)
  Krawitz, P. M., Y. Murakami, J. Hecht, U. Kruger, S. E. Holder, G. R. Mortier, B. delle Chiaie, M. D. Thompson, T. Roscioli, S. Kielbasa, T. Kinoshita, S. Mundlos, P. N. Robinson and D. Horn
- Journal Title
  
  Am. J. Hum. Genet
  
  Volume: 91 Issue: 1 Pages: 146-151
- DOI
  10.1016/j.ajhg.2012.05.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247018, KAKENHI-PROJECT-23590363
[Journal Article] GPI-anchor remodeling : potential functions of GPI-anchors in intracellular trafficking and membrane dynamics2012
- Author(s)
  Fujita, M. and T. Kinoshita
- Journal Title
  
  Biochim. Biophys. Acta - Mol. Cell Biol. Lipids
  
  Volume: 1821 Issue: 8 Pages: 1050-1058
- DOI
  10.1016/j.bbalip.2012.01.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247018
[Journal Article] Persistently high quality of life conferred by coexisting congenital deficiency of terminal complement C9 in a paroxysmal nocturnal hemoglobinuria patient.2012
- Author(s)
  Hanaoka N, Murakami Y, Nagata M, Nagakura S, Yonemura Y, Sonoki T, Kinoshita T, Nakakuma H.
- Journal Title
  
  Blood
  
  Volume: 119(16) Issue: 16 Pages: 3866-3868
- DOI
  10.1182/blood-2012-02-408161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590363, KAKENHI-PROJECT-23791087
[Journal Article] Mechanism for release of alkaline phosphatase caused by glycosylphosphatidylinositol deficiency in patients with hyperphosphatasia-mental retardation syndrome2012
- Author(s)
  Murakami, Y., N. Kanzawa, K. Saito, P. M. Krawitz, S. Mundlos, P. N. Robinson, A. Karadimitris, Y. Maeda and T. Kinoshita
- Journal Title
  
  J. Biol. Chem
  
  Volume: 287 Issue: 9 Pages: 6318-6325
- DOI
  10.1074/jbc.m111.331090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247018, KAKENHI-PROJECT-23590363, KAKENHI-PROJECT-23790365
[Journal Article] Mechanism for release of alkaline phosphatase caused by glycosylphosphatidylinositol deficiency in patients with hyperphosphatasia mental retardation syndrome.2012
- Author(s)
  Murakami Y, Kanzawa N, Saito K, Krawitz PM, Mundlos S, Robinson PN, Karadimitris A, Maeda Y, Kinoshita T.
- Journal Title
  
  J Biol Chem.
  
  Volume: 287 Pages: 6318-6325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590363
[Journal Article] Enhanced response of T lymphocytes from Pgap3 knockout mouse : Insight into roles of fatty acid remodeling of GPI anchored proteins2012
- Author(s)
  Murakami, H., Y. Wang, H. Hasuwa, Y. Maeda, T. Kinoshita and Y. Murakami
- Journal Title
  
  Biochem. Biophys. Res. Comm
  
  Volume: 417 Issue: 4 Pages: 1235-1241
- DOI
  10.1016/j.bbrc.2011.12.116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247018
[Journal Article] Defective lipid remodeling of GPI anchors in peroxisomal disorders, Zellweger syndrome and rhizomelic chondrodysplasia punctata2012
- Author(s)
  Kanzawa, N., et al.
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 53 Issue: 4 Pages: 653-663
- DOI
  10.1194/jlr.m021204
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058011, KAKENHI-PROJECT-21247018, KAKENHI-PROJECT-21591318, KAKENHI-PROJECT-23790365, KAKENHI-PROJECT-24247038, KAKENHI-PROJECT-24390261
[Journal Article] Structural remodeling, trafficking and functions of glycosylphosphatidylinositol anchored proteins2011
- Author(s)
  Maeda, Y. and T. Kinoshita
- Journal Title
  
  Prog. Lipid Res
  
  Volume: 50 Issue: 4 Pages: 411-422
- DOI
  10.1016/j.plipres.2011.05.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247018
[Journal Article] Sorting of GPI-anchored proteins into ER-exit sites by p24 proteins is dependent on remodeled GPI2011
- Author(s)
  Fujita, M., R. Watanabe, N. Jaensch, M. Romanova-Michaelides, T. Satoh, M. Kato, H. Riezman, Y. Yamaguchi, Y. Maeda and T. Kinoshita
- Journal Title
  
  J. Cell Biol
  
  Volume: 194 Issue: 1 Pages: 61-75
- DOI
  10.1083/jcb.201012074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247018, KAKENHI-PUBLICLY-22020037, KAKENHI-PUBLICLY-23121532
[Journal Article] Biogenesis of GPI-anchored proteins is essential for surface expression of sodium channels in zebrafish Rohon-Beard neurons to respond to mechanosensory stimulation2010
- Author(s)
  Nakano, Y., M. Fujita, K. Ogino, T. Kinoshita, Y. Oda and H. Hirata
- Journal Title
  
  Development
  
  Volume: 137 Issue: 10 Pages: 1689-1698
- DOI
  10.1242/dev.047464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247018, KAKENHI-PROJECT-22300126
[Journal Article] The acidic environment of the Golgi is critical for glycosylation and transport2010
- Author(s)
  Maeda, Y. and T. Kinoshita
- Journal Title
  
  Methods Enzymol
  
  Volume: 480 Pages: 495-510
- DOI
  10.1016/s0076-6879(10)80022-9
- ISBN
  9780123809995
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247018
[Journal Article] Structural remodeling of GPI anchors during biosynthesis and after attachment to proteins2010
- Author(s)
  Fujita, M. and T. Kinoshita
- Journal Title
  
  FEBS Lett
  
  Volume: 584 Issue: 9 Pages: 1670-1677
- DOI
  10.1016/j.febslet.2009.10.079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247018
[Journal Article] Controlled expression of branch-forming mannosyltransferase is critical for mycobacterial lipoarabinomannan biosynthesis2010
- Author(s)
  Sena, C. B., T. Fukuda, K. Miyanagi, S. Matsumoto, K. Kobayashi, Y. Murakami, Y. Maeda, T. Kinoshita and Y. S. Morita
- Journal Title
  
  J. Biol. Chem
  
  Volume: 285 Issue: 18 Pages: 13326-13336
- DOI
  10.1074/jbc.m109.077297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247018
[Journal Article] Peroxisome dependency of alkyl-containing GPI-anchor biosynthesis in the endoplasmic reticulum2009
- Author(s)
  Kanzawa, N., Y. Maeda, H. Ogiso, Y. Murakami, R. Taguchi, and T. Kinoshita
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 106 Issue: 42 Pages: 17711-17716
- DOI
  10.1073/pnas.0904762106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247018
[Journal Article] GPI-glycan remodeling by PGAP5 regulates transport of GPI-anchored proteins from the ER to the Golgi2009
- Author(s)
  Fujita, M., Y. Maeda, M. Ra, Y. Yamaguchi, R. Taguchi and T. Kinoshita
- Journal Title
  
  Cell
  
  Volume: 139 Issue: 2 Pages: 352-365
- DOI
  10.1016/j.cell.2009.08.040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247018
[Journal Article] Designing sleeping sickness control2008
- Author(s)
  Kinoshita, T.
- Journal Title
  
  ACS Chem. Biol 3
  
  Pages: 601-603
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390119
[Journal Article] Designing sleeping sickness control.2008
- Author(s)
  Kinoshita, T
- Journal Title
  
  ACS Chem. Biol. 3
  
  Pages: 601-603
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390119
[Journal Article] Research in Japan has contributed to the understanding of GPI anchor deficiency2007
- Author(s)
  Murakami, Y., T., Kinoshita
- Journal Title
  
  In Glycoscience Lab Manual. Ed., Springer, Tokyo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591060
[Journal Article] (* equally contributed) Targeted therapy for inherited GPI deficiency2007
- Author(s)
  Almeida, A M., Y., Murakami, A., Baker, Y., Maeda, I., A G., Roberts, T., Kinoshita, D M., Layton, A., Karadimitris
- Journal Title
  
  N. Engl. J. Med 356
  
  Pages: 1641-1647
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591060
[Journal Article] Targeted Therapy for Inherited GPI Deficiency2007
- Author(s)
  Almeida, A. M., *Y. Murakami*, A. Baker, Y. Maeda, I. A. G. Roberts, T. Kinoshita, D. M. Layton, and A. Karadimitris.(*equally contributed)
- Journal Title
  
  N Engl J Med. 356・16
  
  Pages: 1641-1647
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591060
[Journal Article] Molecular basis of clonal expansion of hematopoiesis in two patients with paroxysmal nocturnal hemoglobinuria (PNH)2006
- Author(s)
  Inoue, N., T., Izui-Sarumaru, Y., Murakami, Y., Endo, J., Nishimura, K., Kurokawa, M., Kuwayama, H., Shime, T., Machii, Y., Kanakura, G., Meyers, C., Wittwer, Z., Chen, W., Babcock, D., Frei-Lahr, C., Parker, T., Kinoshita
- Journal Title
  
  Blood 108
  
  Pages: 4232-4236
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591060
[Journal Article] Molecular basis of clonal expansion. of hematopoiesis in two patients with paroxysmal nocturnal hemoglobinuria(PNH).2006
- Author(s)
  Inoue, N., T. Izui-Sarumaru, Y. Murakami, Y. Endo, J. Nishimura, K. Kurokawa, M. Kuwayama, H. Shime, T. Machii, Y. Kanakura, G. Meyers, C. Wittwer, Z. Chen, W. Babcock, D. Frei-Lahr, C. Parker and T. Kinoshita.
- Journal Title
  
  Blood 108・13
  
  Pages: 4232-4236
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591060
[Journal Article] Hypomorphic promoter mutation in the mannosyltransfbrase-encoding PIG-M gene causes inherited glycosylphosphatidylinositol deficiency.2006
- Author(s)
  Almeida, A., *Y. Murakami*, M. Layton, P. Hillmen, G. S. Sellick, Y. Maeda, S. Richards, S. Patterson, I. Kotsianidis, L. Mollica, D. Crawford, A. Baker, M. Ferguson, I. Roberts, R. Houlston, T. Kinoshita and A. Karadimitris.(*equally contributed)
- Journal Title
  
  Nat. Med., 12
  
  Pages: 846-851
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591060
[Journal Article] (*equally contributed) Hypomorphic promoter mutation in the mannosyltransferase-encoding PIG-Mgene causes inherited glycosylphosphatidylinositol deficiency2006
- Author(s)
  Almeida, A., Y., Murakami, M., Layton, P., Hillmen, G S., Sellick, Y., Maeda, S., Richards, S., Patterson, I., Kotsianidis, L., Mollica, D., Crawford, A., Baker, M., Ferguson, I., Roberts, R., Houlston, T., Kinoshita, A., Karadimitris
- Journal Title
  
  Nat. Med 12
  
  Pages: 846-851
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591060
[Presentation] GPIアンカー欠損症の分子病態2021
- Author(s)
  木下タロウ
- Organizer
  名城大学難治疾患研究センターセミナー
- Invited
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] 小胞体におけるGPI生合成の制御機構2021
- Author(s)
  木下タロウ
- Organizer
  大阪大学タンパク質研究所セミナー
- Invited
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] GPIアンカー欠損症の分子病態2021
- Author(s)
  木下タロウ
- Organizer
  名城大学難治疾患研究センターセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-16H04753
[Presentation] 小胞体におけるGPI生合成の制御2021
- Author(s)
  木下タロウ
- Organizer
  大阪大学タンパク研セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-16H04753
[Presentation] Basic Science and Potential Treatment of GPI disorders2020
- Author(s)
  木下タロウ
- Organizer
  11th Annual SBP Rare Disease Day Symposium and 3rd Biennial CDG Family Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] Molecular pathogenesis of GPI anchor deficiencies2020
- Author(s)
  Taroh Kinoshita
- Organizer
  Mexican Society of Human Genetics
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04753
[Presentation] Molecular pathogenesis of GPI anchor deficiencies2020
- Author(s)
  Taroh Kinoshita
- Organizer
  Mexican Society of Human Genetics
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] 補体とGPIアンカーに出会って2020
- Author(s)
  木下タロウ
- Organizer
  第73回日本細菌学会関西支部総会
- Invited
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] Cross-talk of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis2020
- Author(s)
  Taroh Kinoshita
- Organizer
  Society for Glycobiology 2020 Virtual Annual Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04753
[Presentation] Basic science and potential treatment of GPI disorders2020
- Author(s)
  Taroh Kinoshita
- Organizer
  SBP Medical Discovery Institute Rare Disease Day Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04753
[Presentation] Glycosylphosphatidylinositol: glycan and phospholipid in one molecule2020
- Author(s)
  Taroh Kinoshita
- Organizer
  RIKEN International Symposium on Glyco-lipidologue
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04753
[Presentation] 補体とGPIアンカーに出会って2020
- Author(s)
  木下タロウ
- Organizer
  第73回日本細菌学会関西支部会総会
- Invited
- Data Source
  KAKENHI-PROJECT-16H04753
[Presentation] Cross-talk of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis.2020
- Author(s)
  Taroh Kinoshita
- Organizer
  Society for Glycobiology
- Invited
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] Glycosylphosphatidylinositol: glycan and phospholipid in one molecule2020
- Author(s)
  木下タロウ
- Organizer
  International Symposium on Glyco-lipidologue
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] Regulation of Glycosylphosphatidylinositol Biosynthesis2019
- Author(s)
  木下タロウ
- Organizer
  25th International Symposium on Glycoconjugate (Glyco 25)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] Interactions between GPI-anchor biosynthesis and glycosphingolipid biosynthesis2019
- Author(s)
  Kinoshita, T.
- Organizer
  Gordon Research Conference on Glycobiology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] 補体Update2019
- Author(s)
  木下タロウ
- Organizer
  日本神経学会
- Invited
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] Side-Chain Modification of Mammalian GPI-Anchors2019
- Author(s)
  木下タロウ
- Organizer
  Gordon Research Conferences
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] Regulation of glycosylphosphatidylinositol biosynthesis2019
- Author(s)
  Taroh Kinoshita
- Organizer
  International Symposium on Glycoconjugates (Glyco 25)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04753
[Presentation] GPIアンカーの量的制御2019
- Author(s)
  木下タロウ
- Organizer
  日本分子生物学会
- Invited
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] Side-chain modification of mammalian GPI-anchors2019
- Author(s)
  Taroh Kinoshita
- Organizer
  Gordon Research Conference on Carbohydrates
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04753
[Presentation] Regulation of glycosylphosphatidylinositol biosynthesi2019
- Author(s)
  木下タロウ
- Organizer
  2019 Bilateral Symposium of Academia Sinica-Osaka University
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] Quantity control of GPI biosynthesis2019
- Author(s)
  Taroh Kinoshita
- Organizer
  42nd Annual Meeting of The Molecular Biology Society of Japan
- Invited
- Data Source
  KAKENHI-PROJECT-16H04753
[Presentation] Interactions between GPI-anchor biosynthesis and glycosphingolipid biosynthesis2019
- Author(s)
  Taroh Kinoshita
- Organizer
  Gordon Research Conference on Glycobiology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04753
[Presentation] Beta-1,3-galactosyltransferase 4 transfers galactose to N-acetylgalactosamine side-chain of GPI2018
- Author(s)
  Wang, Y. and T. Kinoshita
- Organizer
  Glico-T 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] B3GALT4によるGPIアンカー側鎖へのガラクトース付加にはラクトシルセラミドが必要である2018
- Author(s)
  王　宜成、村上良子、木下タロウ
- Organizer
  第３７回日本糖質学会年会
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] PIGT遺伝子欠損によるインフラマソーム活性化メカニズムの解明2018
- Author(s)
  大里真幸子、村上良子、植田康敬、西村純一、金倉譲、木下タロウ
- Organizer
  第５５回日本補体学会学術集会
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] The biosynthesis of GPI anchors and human diseases2018
- Author(s)
  木下タロウ
- Organizer
  国際細胞生物学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] PGAP4の糖転移酵素ドメインに挿入された二つの膜貫通領域は糖脂質GPIの認識に関与しうる2017
- Author(s)
  平田哲也、Sushil Kumar Mishra、中村昇太、齋藤一伸、元岡大祐、高田洋子、神澤範之、村上良子、前田裕輔、藤田盛久、山口芳樹、木下タロウ
- Organizer
  第36回日本糖質学会年会
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] 新規の先天性GPI欠損症、PIGB欠損症について2017
- Author(s)
  村上良子、亀井　淳、宮武聡子、赤坂真奈美、輿水江里子、荒谷菜摘、水無瀬　学、松本直通、木下タロウ
- Organizer
  第59回日本小児神経学会学術集会
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] ショウジョウバエのGPI合成酵素PIG-Bは、核膜で機能する必要がある2017
- Author(s)
  山本(日野)美紀、勝俣　恵理、鈴木えみ子、前田裕輔、木下タロウ、後藤　聡
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] B3GALT4はグリコシルホスファチジルイノシトールの側鎖にガラクトースを転移する2017
- Author(s)
  王宜成、平田哲也、村上良子、前田裕輔、木下タロウ
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] A CRISPR forward genetic screen for GPI-GalNAc-galactosyltransferase2017
- Author(s)
  王　宜成、平田哲也、村上良子、前田裕輔、木下タロウ
- Organizer
  第18回関西グライコサイエンスフォーラム
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] N結合型糖鎖によるGPIアンカー型タンパク質の品質管理と構造変化の調節2017
- Author(s)
  藤田盛久、柳石、郭欣宇、平田哲也、木下タロウ
- Organizer
  第36回日本糖質学会年会
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] PGAP6によるGPIアンカー型タンパク質の選択的切断に関する認識領域の解析2017
- Author(s)
  イゴンヒ、藤田盛久、中西秀樹、村上良子、前田裕輔、木下タロウ
- Organizer
  第36回日本糖質学会年会
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] Structural changes of GPI-anchor in the secretory pathway2017
- Author(s)
  木下タロウ
- Organizer
  米国細胞生物学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] 発作性夜間ヘモグロビン尿症の発症メカニズムの解明2017
- Author(s)
  木下タロウ
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] 小胞体におけるN結合型糖鎖とGPIアンカーの機能的関係2017
- Author(s)
  藤田盛久、Yi-Shi Liu、Xin-Yu Guo、平田哲也、木下タロウ
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] PIGT-PNH 患者における自己炎症メカニズムの解明その1　患者検体からの検討2017
- Author(s)
  村田祥吾、村上良子、大里幸真子、植田康敬、西村純一、井上徳光、川本未知、幸原伸夫、木下タロウ
- Organizer
  第54回日本補体学会学術集会
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] B3GALT4はGPIアンカー側鎖のガラクトースをも転移する2017
- Author(s)
  王宜成、平田哲也、村上良子、前田裕輔、木下タロウ
- Organizer
  第36回日本糖質学会年会
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] PIGT-PNH 患者における自己炎症メカニズムの解明　その2　ヒト単球細胞株での解析2017
- Author(s)
  大里真幸子、村上良子、村田祥吾、植田康敬、西村純一、金倉　譲、木下タロウ
- Organizer
  第54回日本補体学会学術集会
- Data Source
  KAKENHI-PLANNED-17H06422
[Presentation] Paroxysmal nocturnal hemoglobinuria caused by PIGT mutations; Atypical PNH2016
- Author(s)
  Yoshiko Murakami, Michi Kawamoto, Norimitsu Inoue, Makiko Osato, Shogo Murata, Sho Murase, Hajime Yoshimura, Yasutaka Ueda, Jun-ichi Nishimura, Yuzuru Kanakura, Nobuo Kohara, and Taroh Kinoshita
- Organizer
  The 58th ASH Annual Meeting
- Place of Presentation
  San Diego
- Year and Date
  2016-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15362
[Presentation] Paroxysmal nocturnal hemoglobinuria caused by PIGT mutations; Atypical PNH2016
- Author(s)
  Yoshiko Murakami, Norimitsu Inoue, Michi Kawamotoi, Nobuo Kohara, Taroh Kinoshita
- Organizer
  The XXVI　International Complement Workshop
- Place of Presentation
  金沢
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15362
[Presentation] Structural Changes of GPI Anchor after its Attachment to Proteins : Functional Significance2014
- Author(s)
  Taroh Kinoshita
- Organizer
  IUBMB 10^<th> International Symposium on Biochemical Roles of Eukaryotic Cell Surface Macromolecules
- Place of Presentation
  Kolkata, India
- Year and Date
  2014-01-24
- Data Source
  KAKENHI-PROJECT-21247018
[Presentation] Structural Changes of GPI Anchor after its Attachment to Proteins: Functional Significance.2014
- Author(s)
  Taroh Kinoshita
- Organizer
  IUBMB 10th International Symposium on Biochemical Roles of Eukaryotic Cell Surface Macromolecules
- Place of Presentation
  インド国、コルカタ市
- Invited
- Data Source
  KAKENHI-PROJECT-21247018
[Presentation] Inherited GPI-anchor deficiencies caused by the hypomorphic mutations in PIGA gene: comparison to paroxysmal nocturnal hemogrobinuria2013
- Author(s)
  Yoshiko Murakami, Mitsuhiro Kato, Hirotomo Saitsu, Kenjiro Kikuchi, Shuei, Watanabe, Mizue Iai, Ryuki Matsuura, Rumiko Takayama, Chihiro Ohba, Shin-ichiro Hamano, Hitoshi Osaka, Kiyoshi Hayasaka, Naomichi Matsumoto, Taroh Kinoshita
- Organizer
  55^<th> ASH Annual Meeting and Exposition
- Place of Presentation
  New Orleans, LA USA
- Year and Date
  2013-12-09
- Data Source
  KAKENHI-PROJECT-23590363
[Presentation] Inherent resistance to eculizumab in PNH2013
- Author(s)
  Masaki Yamamoto, Jun-ichi Nishimura, Shin Hayashi, Kazuma Ohyashiki, Kiyoshi Ando, Hedeyuki Noji, Kunio Kitamura, Tetsuya Eto, Toshihiko Ando, Masayuki Masuko, Tutomu Shichishima, Hirohiko Shibayama, Masakazu Hase, Johji Inazawa, Taroh Kinoshita, Yuzuru Kanakura
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2013-10-11
- Data Source
  KAKENHI-PROJECT-23590363
[Presentation] タンパク質への付加後に起こるGPIアンカーの構造変化の機能的意義2013
- Author(s)
  木下タロウ
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-21247018
[Presentation] 精神発達遅延・てんかんを主症状とする疾患:先天性GPI欠損症の疾患概念の確立に向けて2013
- Author(s)
  村上良子, 井上徳光, 九鬼一郎, 高橋幸利, 木下タロウ
- Organizer
  第55回日本小児神経学会学術集会
- Place of Presentation
  大分市
- Year and Date
  2013-05-31
- Data Source
  KAKENHI-PROJECT-23590363
[Presentation] Remodeling and function of GPI anchors in protein sorting, trafficking, and dynamics.2013
- Author(s)
  Taroh Kinoshita
- Organizer
  FASEB Science Research Conferences: Protein Lipidation, Signaling, and Membrane Domains
- Place of Presentation
  米国バーモント州Saxtons River市
- Invited
- Data Source
  KAKENHI-PROJECT-21247018
[Presentation] 精神発達遅滞・てんかんを主症状とする疾患2013
- Author(s)
  村上良子、　井上徳光、　九鬼一郎、　高橋幸利、木下タロウ
- Organizer
  第50回補体シンポジウム
- Place of Presentation
  旭川医科大学
- Data Source
  KAKENHI-PROJECT-23590363
[Presentation] 精神発達遅延・てんかんを主症状とする疾患：先天性GPI欠損症の疾患概念の確立に向けて2013
- Author(s)
  村上良子、井上徳光、九鬼一郎、高橋幸利、木下タロウ
- Organizer
  第55回日本小児神経学会学術集会
- Place of Presentation
  大分市
- Data Source
  KAKENHI-PROJECT-23590363
[Presentation] GPIアンカー生合成に関与する遺伝子群の解析2013
- Author(s)
  藤田盛久, 中村昇太, 平田哲也, 村上良子, 前田裕輔, 木下タロウ
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜市
- Year and Date
  2013-09-12
- Data Source
  KAKENHI-PROJECT-23590363
[Presentation] タンパク質への付加後に起こるGPI アンカーの構造変化の機能的意義2013
- Author(s)
  木下タロウ, 前田裕輔, 藤田盛久
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸国際会館他
- Year and Date
  2013-12-04
- Data Source
  KAKENHI-PROJECT-21247018
[Presentation] nherent resistance to eculizumab in PNH2013
- Author(s)
  Masaki Yamamoto, Jun-ichi Nishimura, Shin Hayashi, Kazuma Ohyashiki, Kiyoshi Ando, Hedeyuki Noji, Kunio Kitamura, Tetsuya Eto, Toshihiko Ando, Masayuki Masuko, Tutomu Shichishima, Hirohiko Shibayama, Masakazu Hase, Johji Inazawa, Taroh Kinoshita, Yuzuru Kanakura,
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  ロイトン札幌
- Invited
- Data Source
  KAKENHI-PROJECT-23590363
[Presentation] Remodeling and function of GPI anchors in protein sorting, trafficking, and dynamics2013
- Author(s)
  Taroh Kinoshita
- Organizer
  FASEB Science Research Conferences : Protein Lipidation, Signaling, and Membrane Domrins
- Place of Presentation
  Saxtons River, Vermont, USA
- Year and Date
  2013-07-15
- Data Source
  KAKENHI-PROJECT-21247018
[Presentation] 精神発達遅滞・てんかんを主症状とする疾患2013
- Author(s)
  村上良子, 井上徳光, 九鬼一郎, 高橋幸利, 木下タロウ
- Organizer
  第50回補体シンポジウム
- Place of Presentation
  旭川市
- Year and Date
  2013-07-06
- Data Source
  KAKENHI-PROJECT-23590363
[Presentation] Inherited GPI-anchor deficiencies caused by the hypomorphic mutations in PIGA gene: comparison to paroxysmal nocturnal hemogrobinuria2013
- Author(s)
  Yoshiko Murakami, Mitsuhiro Kato, Hirotomo Saitsu, Kenjiro Kikuchi, Shuei, Watanabe, Mizue Iai, Ryuki Matsuura, Rumiko Takayama, Chihiro Ohba, Shin-ichiro Hamano, Hitoshi Osaka, Kiyoshi Hayasaka, Naomichi Matsumoto, Taroh Kinoshita,
- Organizer
  55th ASH Annual Meeting and Exposition
- Place of Presentation
  New Orleans, LA USA.
- Invited
- Data Source
  KAKENHI-PROJECT-23590363
[Presentation] GPIアンカー生合成に関与する遺伝子群の解析2013
- Author(s)
  藤田盛久、中村昇太、平田哲也、村上良子、前田裕輔、木下タロウ
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590363
[Presentation] GPIアンカー型タンパク質の輸送とアンカー切断に関わる膜ドメイン2012
- Author(s)
  木下タロウ
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-21247018
[Presentation] 先天性GPI欠損症 -疾患概念の確立に向けて-2012
- Author(s)
  村上良子、井上徳光、高橋幸利、木下タロウ
- Organizer
  第３５回分子生物学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23590363
[Presentation] 発作性夜間血色素尿症におけるGPI欠損細胞の拡大機序について2012
- Author(s)
  村上良子、井上徳光、金倉譲、西村純一、木下タロウ
- Organizer
  第49回補体シンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23590363
[Presentation] Deficiencies of GPI mannosyltransferases 1 and 2 cause different fates of GPI anchored proteins.2012
- Author(s)
  Taroh Kinoshita
- Organizer
  GlycoT 2012 Hannover
- Place of Presentation
  ドイツ国ハノーバー市
- Invited
- Data Source
  KAKENHI-PROJECT-21247018
[Presentation] ＧＰＩアンカータンパク質の輸送異常細胞株の樹立と解析2012
- Author(s)
  木下タロウ
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-21247018
[Presentation] GPI アンカー型タンパク質の輸送とアンカー切断に関わる膜ドメイン -- Transport and anchor-cleavage of GPI-ancired proteins in relation to membrane domains2012
- Author(s)
  木下タロウ, 前田裕輔, 藤田盛久
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場他
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PROJECT-21247018
[Presentation] Deficiencies of GPI mannosyltransferases 1 and 2 cause different fates of GPI anchored proteins2012
- Author(s)
  Taroh Kinoshita
- Organizer
  GlycoT 2012 Hannover
- Place of Presentation
  Hannover Germany
- Year and Date
  2012-06-07
- Data Source
  KAKENHI-PROJECT-21247018
[Presentation] GPI アンカー型タンパク質の切断に関与する新規酵素の機能解析2012
- Author(s)
  藤田盛久, 李健熺, 村上良子, 前田裕輔, 木下タロウ
- Organizer
  第31回日本糖質学会年会
- Place of Presentation
  鹿児島市民文化ホール
- Data Source
  KAKENHI-PROJECT-21247018
[Presentation] Screening patients with inherited GPI anchor deficiency to establish concept of the new disease2012
- Author(s)
  Yoshiko Murakami, Norimitsu Inoue, Yusuke Maeda, Yukitoshi Takahashi, Taroh Kinoshita
- Organizer
  XXIV International Complement Workshop
- Place of Presentation
  クレタ島ギリシャ
- Year and Date
  2012-10-12
- Data Source
  KAKENHI-PROJECT-23590363
[Presentation] Screening patients with inherited GPI anchor deficiency to establish concept of the new disease2012
- Author(s)
  Yoshiko Murakami, Norimitsu Inoue, Yusuke Maeda, Yukitoshi Takahashi, Taroh Kinoshita
- Organizer
  XXIV International Complement Workshop
- Place of Presentation
  クレタ島ギリシャ
- Year and Date
  2012-10-12
- Data Source
  KAKENHI-PROJECT-21247018
[Presentation] Screening patients with inherited GPI anchor deficiency to establish concept of the new disease2012
- Author(s)
  Yoshiko Murakami, Norimitsu Inoue, Yusuke Maeda, Yukitoshi Takahashi and Taroh Kinoshita
- Organizer
  XXIV International Complement Workshop
- Place of Presentation
  Chania, Greece
- Data Source
  KAKENHI-PROJECT-23590363
[Presentation] 先天性GPI欠損症-疾患概念の確率に向けて—Screening patients with inhierited GPI anchor deficiency to establish cincept of the new disease2012
- Author(s)
  村上良子, 井上徳光, 高橋幸利, 木下タロウ
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡市
- Year and Date
  2012-12-12
- Data Source
  KAKENHI-PROJECT-23590363
[Presentation] 補体研究:基礎から臨床へ発作性夜間血色素尿症をはじめとするGPI欠損症について2011
- Author(s)
  村上良子, 井上徳光, 七島勉, 太田里永子, 野地秀義, 前田裕輔, 西村純一, 木下タロウ
- Organizer
  第48回補体シンポジウム
- Place of Presentation
  名古屋市(特別企画シンポジウム)
- Year and Date
  2011-09-02
- Data Source
  KAKENHI-PROJECT-23590363
[Presentation] 発作性夜間血色素尿症をはじめとするGPI欠損症について2011
- Author(s)
  村上良子、太田里永子、井上徳光、木下タロウ
- Organizer
  第４８回補体シンポジウム「補体研究：基礎から臨床へ」(招待講演)
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23590363
[Presentation] Release of alkaline phosphatase caused by PIGV mutations in patients with Hyperphosphatasia-Mental Retardation syndrome (HPMR), a recently found second inherited GPI anchor deficiency2011
- Author(s)
  Yoshiko Murakami, Peter M. Krawitz, Peter N. Robinson, Stefan Mundlos, Noriyuki Kanzawa, Yusuke Maeda, Taroh Kinoshita
- Organizer
  Glyco 21 (21th International Symposium on Glyconjugates)
- Place of Presentation
  ウィーン, オーストリア
- Year and Date
  2011-08-22
- Data Source
  KAKENHI-PROJECT-23590363
[Presentation] Remodeling of GPI anchors in the ER before and after attachment to proteins : mechanisms and functions.2011
- Author(s)
  Taroh Kinoshita
- Organizer
  Glyco 21(21th International Symposium on Glyconjugates)
- Place of Presentation
  ウィーン, オーストリア
- Year and Date
  2011-08-23
- Data Source
  KAKENHI-PROJECT-21247018
[Presentation] Remodeling of GPI anchors in the ER before and after attachment to proteins : mechanisms and functions2011
- Author(s)
  Taroh Kinoshita
- Organizer
  Glyco 21 (21th International Symposium on Glycon jugates)
- Place of Presentation
  オーストリア国ウィーン市(招待講演)
- Year and Date
  2011-08-23
- Data Source
  KAKENHI-PROJECT-21247018
[Presentation] Release of alkaline phosphatase caused by PIGVmutations in patients with Hyperphosphatasia-Mental Retardation syndrome (HPMR), recently found second inherited GPI anchor deficiency.2011
- Author(s)
  Murakami,Y., Krawitz, PM., Robinson, PN, Mundlos, S., Maeda Y., and Kinoshita,T.
- Organizer
  Glyco 21
- Place of Presentation
  ウィーン
- Data Source
  KAKENHI-PROJECT-23590363
[Presentation] The pathogenesis of PNH2010
- Author(s)
  Taroh Kinoshita
- Organizer
  The Second Session of Blood Diseases, Forum of Institute of Hematology & Hospital of Blood Diseases CAMs & PUMC
- Place of Presentation
  Tianjin China
- Year and Date
  2010-05-06
- Data Source
  KAKENHI-PROJECT-21247018
[Presentation] Remodeling of GPI-ancherd protein during biosynthesis in and transport from the ER, Towards a comprehensive understanding of endoplasmic reticulum functions2010
- Author(s)
  Taroh Kinoshita
- Organizer
  EMBO Conference series
- Place of Presentation
  Girona Spain
- Year and Date
  2010-10-04
- Data Source
  KAKENHI-PROJECT-21247018
[Presentation] Remodeling of GPI-ancherd protein during biosynthesis in transport for the ER.2010
- Author(s)
  Taroh Kinoshita
- Organizer
  EMBO Conference series ; Towards a comprehensive understanding of endoplasmic reticulum functions.
- Place of Presentation
  Girona Spain
- Data Source
  KAKENHI-PROJECT-21247018
[Presentation] The pathogenesis of PNH2010
- Author(s)
  Taroh Kinoshita
- Organizer
  The Second Session of Blood Diseases Forum of Institute of Hematology & Hospital of Blood Diseases CAMs & PUMC
- Place of Presentation
  Tianjin China
- Data Source
  KAKENHI-PROJECT-21247018
[Presentation] GPI-glycan remodeling by PGAP5 regulates transport of GPI-anchored proteins from the ER to the Golgi.2009
- Author(s)
  Taroh Kinoshita
- Organizer
  20^<th> International Symposium on Glycoconju gates
- Place of Presentation
  San Juan, Perto Rico, USA
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-21247018
[Presentation] GPI-glycan remodeling by PGAP5 regulates transport of GPI-anchored proteins from the ER to the Golgi2009
- Author(s)
  Taroh Kinoshita, Yusuke Maeda, Moonjin Ra, Yoshiki Yamaguchi, Ryo Taguti, Morihisa Fujita
- Organizer
  20^<th> International Symposium on Glycoconjugates
- Place of Presentation
  San Juan, Perto Rico, USA
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-21247018
[Presentation] 遺伝性GPIアンカー欠損症と治療について2007
- Author(s)
  村上良子、前田裕輔、Antonio Almeida、Anastasios Karadimitris、木下タロウ
- Organizer
  第44回補体シンポジウム
- Place of Presentation
  平塚市
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591060
[Presentation] 遺伝性GPIアンカー欠損症2006
- Author(s)
  木下タロウ、村上良子、前田裕輔、Antonio Almeida、 Anastasios Karadimitris
- Organizer
  第43回補体シンポジウム
- Place of Presentation
  福岡
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591060
[Presentation] A point mutation in an Spl binding motif in the promoter of the mannosyltransferase-encoding PIG-Mgene causes inherited glycosylphosphatidylinositol deficiency2006
- Author(s)
  Yoshiko, Murakami, Antonio, Almeida, Mark, Layton, Peter, Hillmen, Yusuke, Maeda, Anastasios, Karadimitris, Taroh, Kinoshita
- Organizer
  XXIth International Complement Workshop
- Place of Presentation
  Beijing China
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591060
[Presentation] 遺伝性GPIアンカー欠損症の2家系2006
- Author(s)
  村上良子、前田裕輔、木下タロウ
- Organizer
  第68回日本血液学会総会第48回日本臨床血液学会合同総会
- Place of Presentation
  福岡
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591060
[Presentation] A point mutation in an Sp1 binding motif in the promoter of the mannosyltransferase-encoding PIG-M gene causes inherited glycosylphosphatidylinositol deficiency.2006
- Author(s)
  Yoshiko Murakami, Antonio Almeida, Mark Layton, Peter Hillmen, Yusuke Maeda, Anastasios Karadimitris and Taroh Kinoshita
- Organizer
  XXIth International Complement Workshop
- Place of Presentation
  Beijing China
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591060
[Presentation] A point mutation in an Sp1 binding motif in the promoter of the mannosyltransferase-encoding PIG-M gene causes inherited glycosylphosphatid ylinositol deficiency.2006
- Author(s)
  Yoshiko Murakami, Antonio Almeida, Mark Layton, Peter Hillmen, Yusuke Maeda, Anastasios Karadimitris and Taroh Kinoshita
- Organizer
  20th IUBMB International Congress
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591060
[Presentation] A point mutation in an Spl binding motif in the promoter of the mannosyltransferase-encoding PIG-M gene causes inherited glycosylphosphatidylinositol deficiency2006
- Author(s)
  Yoshiko, Murakami, Antonio, Almeida, Mark, Layton, Peter, Hillmen, Yusuke, Maeda, Anastasios, Karadimitris, Taroh Kinoshita
- Organizer
  20th IUBMB International Congress
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591060

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111. デルセニー M.

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118. NAKASEKO Nobuyuki

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136. KAMIKUBO Yuji

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139. 松本直通

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140. 後藤聡

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Kinoshita Taroh 木下 タロウ

KINOSHITA Taroh 木下 タロウ

Research Projects

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Co-Researchers

グリコシルホスファチジルイノシトール (GPI) 生合成の制御メカニズムの解明Principal Investigator

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Physiological and pathological roles of GPI side chains and free GPIPrincipal Investigator

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Molecular mechanisms and functions of structural changes of protein GPI-anchorsPrincipal Investigator

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Stage specific modifications of GPI anchor in Trypanosoma bruceiPrincipal Investigator

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Biosynthesis and functions of GPI-anchored proteins in African trypanosomesPrincipal Investigator

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GPIアンカー合成の調節機構と合成不全症Principal Investigator

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Kinoshita Taroh 木下タロウ

KINOSHITA Taroh 木下タロウ