WATANABE KENJI 渡辺賢二

… Alternative Names

WATANABE Kenji 渡辺賢二

渡辺賢二ワタナベケンジ

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Researcher Number	50360938
Other IDs
Affiliation (Current)	2025: 静岡県立大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2015 – 2024: 静岡県立大学, 薬学部, 教授 2009 – 2015: University of Shizuoka, 薬学部, 准教授 2004: 北大, (連合)農学研究科(研究院), 助手
Review Section/Research Field	Principal Investigator Medium-sized Section 38:Agricultural chemistry and related fields / Chemical biology / Science and Engineering / Broad Section F / Transformative Research Areas, Section (II) / Basic Section 38040:Bioorganic chemistry-related / Transition State Control / Chemical biology / Bioproduction chemistry/Bioorganic chemistry / Applied biochemistry … More Except Principal Investigator … More Science and Engineering / Transformative Research Areas, Section (II) / Basic Section 09030:Childhood and nursery/pre-school education-related / Basic Section 08030:Family and consumer sciences, and culture and living-related / Eating habits / Natural medicines / Biomolecular chemistry / Genetics/Genome dynamics / Living organism molecular science Less
Keywords	Principal Investigator 生合成 / 天然物 / 天然物化学 / コリバクチン / 大腸がん / 酵素反応機構 / 大腸菌 / 異種発現 / 抗生物質 / がん化学予防法 … More / 孵化誘因物質 / 農薬 / ステロール / ソラノエクレピンA / 遺伝毒性物質 / 天然物生合成 / 抗腫瘍性抗生物質 / フマギリン / 遺伝子治療 / 反応機構 / Diels-Alder反応 / 糸状菌 / 遺伝子 / 物質生産 / 酵素 / ペプチド / ジャガイモシストセンチュウ / モノクローナル抗体 / 発がんメカニズム / 植物 / 予知生合成 / ステロイド / ジャガイモシストセンチュウ / 生合成メカニズム / ナス科植物 / Micro-Tom / シストセンチュウ孵化誘因物質 / solanoeclepin A / ジャガイモシストセンチュウ孵化誘因物質 / ヒト細胞発現系 / 抗がん剤 / 生合成遺伝子異種発現 / fumagillin / 遺伝子治療法 / 細胞内de novo合成 / 細菌叢 / 大腸ガン / 化学構造解析 / 計算化学 / 酸化反応 / epoxidation / FAD / monooxygenase / spiro-carbon / [4+2]環化反応 / 生合成酵素 / Diels-Alderase / 反応メカニズム / Diels-Alder / アポトーシス / 生物的全合成 / 生物活性 / 生合成遺伝子 / 自己抗生物質 / レトロウイルスベクター / HeLa細胞 / 生合成遺伝子発現 / 機能発現 / 異種宿主発現 / ゲノム情報 / Aspoquinolone / 生合 / 微量天然物 / キノコ / テルペノイド / 生合成リデザイン / 生理活性物質 / 担子菌 / 遺伝子クラスター / リデザイン / タンパク質構造解析 / 活性物質 / 酵素反応 / 遷移状態 / 反応遷移状態 / オクタリン骨格 / Dels-Alder反応 / 腸内細菌 / シンセティックバイオロジー / ケミカルバイオロジー / 脂質 / 診断マーカー / 腸内細菌層 / 遺伝性毒素 / 非リボソーム依存性ペプチド / 酵母 / サフラマイシン / 化学生物学 … More Except Principal Investigator 天然物化学 / 生合成 / 反応機構 / 腸内細菌叢 / 生物分子科学 / 生合成工学 / 合成生物学 / 生合成リデザイン / 生物合成 / 植物 / バイオテクノロジー / 酵素 / 酵素工学 / ゲノム / 情報科学 / 計算科学 / 有機合成 / 国際交流 / 天然有機化合物 / 生物活性物質 / 保育所 / 無作為化介入試験 / 親子 / 介入試験 / 沖縄県 / 行動変容 / 肥満 / 食育 / 社会経済因子 / 母子関係 / 小児肥満因子 / 沖縄の食習慣 / 断面研究 / 小児肥満 / 家庭・地域 / 母子相互関係 / 社会経済因子(沖縄) / 生物分子化学 / 分子代謝学 / 炎症 / 大腸菌 / ケミカルバイオロジー / シンセティックバイオロジー / 光合成細菌 / シアノバクテリア / 天然物 / コルジセピン / キノコ / 微生物 / 酵素化学 / 生物活性 / 抗生物質 / 物質生産 / OAC / polyketide synthase / Type III PKS / X線結晶構造解析 / 閉環酵素 / タンパク質結晶構造解析 / ポリケタイド / 組換え機構 / 遺伝学 / 突然変異 / 遺伝子 / 逆遺伝学 / 分子遺伝 / プレニル基転移酵素 / テレトニン / テルペン環化酵素 / 分子多様性 / メロテルペノイド / biosynthesis / 生理活性 Less

Toward engineered biosynthesis of drugs in human cellsPrincipal Investigator
- Principal Investigator
  
  渡辺賢二
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  University of Shizuoka
予知生合成科学・研究総括班
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  The University of Tokyo
Uncovering a biosynthetic pathway of plant natural product solanoeclepin APrincipal Investigator
- Principal Investigator
  
  渡辺賢二
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  University of Shizuoka
Understanding a mechanism of an onset of colorectal cancer by colibactin and finding compounds inhibiting colibactin biosynthetic enzymesPrincipal Investigator
- Principal Investigator
  
  渡辺賢二
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section F
- Research Institution
  University of Shizuoka
Understanding a mechanism of an onset of colorectal cancer by colibactin and finding a inhibitor to the biosynthetic enzymesPrincipal Investigator
- Principal Investigator
  
  渡辺賢二
- Project Period (FY)
  2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  University of Shizuoka
Influence of dietary habits on intestinal environment of mothers and children in Okinawa: Family and community aspects
- Principal Investigator
  
  等々力英美
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 08030:Family and consumer sciences, and culture and living-related
- Research Institution
  University of the Ryukyus
A Randomized Intervention Trial to Promote Healthy Dietary Intake among Parents and Children in Okinawa: Based on Health Checkup Data of Nursery School
- Principal Investigator
  
  名嘉地めぐみ
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 09030:Childhood and nursery/pre-school education-related
- Research Institution
  University of the Ryukyus
Cell therapy by using engineered biosynthesis of anticancer agent in tumor cellsPrincipal Investigator
- Principal Investigator
  
  Watanabe Kenji
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  University of Shizuoka
Integrating Computational and Experimental Approaches for New Paradigms in Molecule SynthesisPrincipal Investigator
- Principal Investigator
  
  Watanabe Kenji
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  University of Shizuoka
Chemical characterization of colibactin and understanding a mechanism of an onset of colorectal cancer by colibactinPrincipal Investigator
- Principal Investigator
  
  Watanabe Kenji
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  University of Shizuoka
Redesigning Biosynthetic Machineries (Project Team)
- Principal Investigator
  
  Abe Ikuro
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Engineered biosynthesis of new natural products for innovative drug discoveryPrincipal Investigator
- Principal Investigator
  
  Watanabe Kenji
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  University of Shizuoka
Profiling analysis of intestinal endotoxins associated with chronic inflammation in lifestyle-related diseases
- Principal Investigator
  
  Miyoshi Noriyuki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Eating habits
- Research Institution
  University of Shizuoka
Redesigning Biosynthetic Machineries (International Activity Support Team)
- Principal Investigator
  
  Abe Ikuro
- Project Period (FY)
  2016 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Diels-Alder反応を触媒する酵素が持つ遷移状態制御の解明Principal Investigator
- Principal Investigator
  
  渡辺賢二
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Transition State Control
- Research Institution
  University of Shizuoka
Characterization of genotoxins, colibactin, facilitating inflammation-induced colorectal cancerPrincipal Investigator
- Principal Investigator
  
  Watanabe Kenji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Chemical biology
- Research Institution
  University of Shizuoka
Unprecedented enzyme-catalyzed generation of complexity in fumagillin-pseurotin biosynthesis
- Principal Investigator
  
  Noguchi Hiroshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Natural medicines
- Research Institution
  Nihon Pharmaceutical University
  University of Shizuoka
Unification of biosynthetic pathways of a variety of plant polyketides
- Principal Investigator
  
  Noguchi Hiroshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  University of Shizuoka
生合成遺伝子の異種発現によるテトラヒドロイソキノリン類の合成Principal Investigator
- Principal Investigator
  
  渡辺賢二
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  University of Shizuoka
有用天然物の生合成遺伝子発現によるシンセティックバイオロジーの確立Principal Investigator
- Principal Investigator
  
  渡辺賢二
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical biology
- Research Institution
  University of Shizuoka
病原性微生物が生産する天然物の化学構造決定および生合成機構の解明に関する研究Principal Investigator
- Principal Investigator
  
  渡辺賢二
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Chemical biology
- Research Institution
  University of Shizuoka
Generating molecular diversity by the wide range of polyketide synthases
- Principal Investigator
  
  NOGUCHI Hiroshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Living organism molecular science
- Research Institution
  University of Shizuoka
Reverse genetics and recombination
- Principal Investigator
  
  IIDA Shigeru
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Genetics/Genome dynamics
- Research Institution
  University of Shizuoka
Biosynthesis of natural antitumor agents and their rationally engineered analogs in Escherichia coliPrincipal Investigator
- Principal Investigator
  
  WATANABE Kenji
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  University of Shizuoka
セルロース有効利用を目指したセルロース分解酵素クラスターの単離および機能構築Principal Investigator
- Principal Investigator
  
  渡辺賢二
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  Hokkaido University

[Book] Polyketide synthase and nonribosomal peptide synthetase hybrid enzymes of fungi. The Mycota XV: Physiology and Genetics2018
- Author(s)
  Kishimoto, S., Hirayama, Y., Watanabe, K.
- Total Pages
  7
- Publisher
  Springer
- Data Source
  KAKENHI-PLANNED-16H06449
[Book] 天然物の化学Ⅱ（科学のとびら64)2018
- Author(s)
  上村大輔, 渡辺賢二
- Total Pages
  192
- Publisher
  東京化学同人
- ISBN
  9784807915057
- Data Source
  KAKENHI-PLANNED-16H06449
[Book] 天然物生合成におけるS-アデノシルメチオニン依存性酵素により触媒されるペリ環状反応2018
- Author(s)
  大橋雅生, 渡辺賢二
- Total Pages
  6
- Publisher
  現代化学
- Data Source
  KAKENHI-PLANNED-16H06449
[Book] 現代化学2017
- Author(s)
  大橋雅生, 渡辺賢二
- Total Pages
  6
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PLANNED-16H06449
[Book] BIO Clinica2017
- Author(s)
  渡辺賢二
- Total Pages
  4
- Publisher
  北隆館／ニュー・サイエンス社
- Data Source
  KAKENHI-PLANNED-16H06449
[Book] Complex enzymes : overview and peptides(Assembling nonribosomal peptide gene cluster in a heterologous host.)(edited by David Hopwood.)2009
- Author(s)
  Watanabe, K., Praseuth, A.P., Praseuth, M.B., Hotta, K.
- Publisher
  Methods in Enzymology
- Data Source
  KAKENHI-PROJECT-21780106
[Book] 天然物全合成の最新動向(生合成酵素による天然物の全合成-抗腫瘍性物質エキノマイシンの合成を中心に-)(北泰行監修)2009
- Author(s)
  渡辺賢二, 大栗博毅, 及川英秋
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Reactive Azlactone Intermediate Drives Fungal Secondary Metabolite Cross-Pathway Generation2023
- Author(s)
  Kishimoto Shinji、Minami Ayumi、Aoki Yoshimitsu、Matsubara Yuya、Watanabe Shogo、Watanabe Kenji
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 145 Issue: 5 Pages: 3221-3228
- DOI
  10.1021/jacs.2c13188
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14795, KAKENHI-PROJECT-22H04922, KAKENHI-PLANNED-22H05121, KAKENHI-PROJECT-22H04979
[Journal Article] Association between physical activity and the prevalence of tumorigenic bacteria in the gut microbiota of Japanese adults: a cross-sectional study2023
- Author(s)
  Iwasaka Chiharu、Ninomiya Yuka、Nakagata Takashi、Nanri Hinako、Watanabe Daiki、Ohno Harumi、Tanisawa Kumpei、Konishi Kana、Murakami Haruka、Tsunematsu Yuta、Sato Michio、Watanabe Kenji、Miyachi Motohiko
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 20841-20841
- DOI
  10.1038/s41598-023-47442-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K17284, KAKENHI-PROJECT-22K17838, KAKENHI-PROJECT-22K06665, KAKENHI-ORGANIZER-23H03820, KAKENHI-PLANNED-23H03823, KAKENHI-PROJECT-22H04979, KAKENHI-PROJECT-23K27966
[Journal Article] Biosynthetic Gene Expression and Tissue Distribution of Diosgenin in Dioscorea japonica2023
- Author(s)
  Onoda Keita、Kato Mai、Tsunematsu Yuta、Eto Fumihiro、Sato Michio、Yoshioka Yasukiyo、Yoshida Takuya、Tamura Kentaro、Yao Ikuko、Dohra Hideo、Watanabe Kenji、Miyoshi Noriyuki
- Journal Title
  
  Journal of Agricultural and Food Chemistry
  
  Volume: 71 Issue: 10 Pages: 4292-4297
- DOI
  10.1021/acs.jafc.2c08478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06269, KAKENHI-PROJECT-22K06665, KAKENHI-PROJECT-22K11757, KAKENHI-PLANNED-22H05121, KAKENHI-PROJECT-20K05866, KAKENHI-PROJECT-20H04109
[Journal Article] Screening method toward ClbP-specific inhibitors2023
- Author(s)
  Zhou, T., Ando, T., Kudo, A., Sato, M., Miyoshi, N., Mutoh, M., Ishikawa, H., Wakabayashi, K., Watanabe, K.
- Journal Title
  
  Genes and Environment
  
  Volume: 45 Issue: 1 Pages: 8-8
- DOI
  10.1186/s41021-023-00264-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06665, KAKENHI-PROJECT-22H04979
[Journal Article] 抗生物質生産菌が持つ自己耐性酵素の機能解明2023
- Author(s)
  佐藤道大、渡辺賢二
- Journal Title
  
  酵素工学研究会誌
  
  Volume: 89 Pages: 27-30
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22H05121
[Journal Article] Uncommon arrangement of self-resistance allows biosynthesis of de novo purine biosynthesis inhibitor that acts as immunosuppressor2023
- Author(s)
  Sato, M., Sakano, S., Nakahara, M., Tamura, Y., Hara, K., Hashimoto, H., Tang, Y., Watanabe, K.
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 145 Issue: 49 Pages: 26883-26889
- DOI
  10.1021/jacs.3c09600
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06665, KAKENHI-PROJECT-23K05669, KAKENHI-PLANNED-22H05121, KAKENHI-PROJECT-22H04979, KAKENHI-PROJECT-20H03197
[Journal Article] Biosynthesis of polycyclic natural products from conjugated polyenes via tandem isomerization and pericyclic reactions2023
- Author(s)
  Niwa, K., Ohashi, M., Xie, K., Chiang, C. Y., Jamieson, C. S., Sato, M., Watanabe, K., Liu, F., Houk, K. N., Tang, Y.
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 145 Issue: 25 Pages: 13520-13525
- DOI
  10.1021/jacs.3c02380
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06665, KAKENHI-PLANNED-22H05121, KAKENHI-PROJECT-22H04979
[Journal Article] Non-target GC-MS analyses of fecal VOCs in NASH-hepatocellular carcinoma model STAM mice2023
- Author(s)
  Kato Mai、Yamaguchi Momoka、Ooka Akira、Takahashi Ryota、Suzuki Takuji、Onoda Keita、Yoshikawa Yuko、Tsunematsu Yuta、Sato Michio、Yoshioka Yasukiyo、Igarashi Miki、Hayakawa Sumio、Shoji Kumiko、Shoji Yutaka、Ishikawa Tomohisa、Watanabe Kenji、Miyoshi Noriyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 8924-8924
- DOI
  10.1038/s41598-023-36091-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K17781, KAKENHI-PROJECT-22K06665, KAKENHI-PROJECT-22K07078, KAKENHI-PROJECT-22K11757, KAKENHI-PROJECT-21K19727, KAKENHI-ORGANIZER-23H03820, KAKENHI-PLANNED-23H03823, KAKENHI-PROJECT-22H04979, KAKENHI-PROJECT-20H04109, KAKENHI-PROJECT-23K28004
[Journal Article] 大腸菌が産生する発がんリスク因子「コリバクチン」の化学構造の全容解明2022
- Author(s)
  平山　裕一郎、渡辺　賢二
- Journal Title
  
  化学と生物
  
  Volume: 3 Pages: 123-130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H02898
[Journal Article] Novel Gene Therapy by Expression of Biosynthetic Function2022
- Author(s)
  Matsuda Shinya、Watanabe Kenji
- Journal Title
  
  Journal of Synthetic Organic Chemistry, Japan
  
  Volume: 80 Issue: 8 Pages: 747-754
- DOI
  10.5059/yukigoseikyokaishi.80.747
- ISSN
  0037-9980, 1883-6526
- Year and Date
  2022-08-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19158
[Journal Article] Cytotoxic Homo- and Hetero-Dimers of o-toluidine, o-anisidine, and Aniline Formed by In Vitro Metabolism2022
- Author(s)
  Kobayashi Takuma、Kishimoto Shinji、Watanabe Shogo、Yoshioka Yasukiyo、Toyoda Takeshi、Ogawa Kumiko、Watanabe Kenji、Totsuka Yukari、Wakabayashi Keiji、Miyoshi Noriyuki
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 35 Issue: 9 Pages: 1625-1630
- DOI
  10.1021/acs.chemrestox.2c00226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K11757, KAKENHI-PROJECT-22H04979
[Journal Article] Advancing the Biosynthetic and Chemical Understanding of the Carcinogenic Risk Factor Colibactin and Its Producers2022
- Author(s)
  Hirayama Yuichiro、Sato Michio、Watanabe Kenji
- Journal Title
  
  Biochemistry
  
  Volume: 61 Issue: 24 Pages: 2782-2790
- DOI
  10.1021/acs.biochem.2c00229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06665, KAKENHI-PROJECT-22H04979
[Journal Article] Toward Engineered Biosynthesis of Drugs in Human Cells2021
- Author(s)
  Matsuda Shinya、Tsunematsu Yuta、Matsushita Takuma、Ogata Yuji、Hachiya Shihomi、Kishimoto Shinji、Miyoshi Noriyuki、Watanabe Kenji
- Journal Title
  
  ChemBioChem
  
  Volume: 23 Issue: 4 Pages: 1-7
- DOI
  10.1002/cbic.202100645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22291, KAKENHI-PROJECT-20K05866
[Journal Article] Catalytic mechanism and endo-to-exo selectivity reversion of an octalin-forming natural Diels?Alderase2021
- Author(s)
  Sato Michio、Kishimoto Shinji、Yokoyama Mamoru、Jamieson Cooper S.、Narita Kazuto、Maeda Naoya、Hara Kodai、Hashimoto Hiroshi、Tsunematsu Yuta、Houk Kendall N.、Tang Yi、Watanabe Kenji
- Journal Title
  
  Nature Catalysis
  
  Volume: 4 Issue: 3 Pages: 223-232
- DOI
  10.1038/s41929-021-00577-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05866, KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-20H03197, KAKENHI-PROJECT-17K07314, KAKENHI-PROJECT-19K07136, KAKENHI-PROJECT-19KK0150
[Journal Article] ディールス－アルダラーゼとはどういった酵素なのか2021
- Author(s)
  佐藤道大, 渡辺賢二
- Journal Title
  
  化学
  
  Volume: 2 Pages: 72-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19KK0150
[Journal Article] Isolation of New Colibactin Metabolites from Wild-Type Escherichia coli and In Situ Trapping of a Mature Colibactin Derivative2021
- Author(s)
  Tao Zhou, Yuichiro Hirayama, Yuta Tsunematsu, Nanami Suzuki, Seiji Tanaka, Nahoko Uchiyama, Yukihiro Goda, Yuko Yoshikawa, Yuji Iwashita, Michio Sato, Noriyuki Miyoshi, Michihiro Mutoh, Hideki Ishikawa, Haruhiko Sugimura, Keiji Wakabayashi, and Kenji Watanabe*
- Journal Title
  
  JACS
  
  Volume: 1 Pages: 1-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H02898
[Journal Article] Discovery and investigation of natural Diels?Alderases2021
- Author(s)
  Watanabe Kenji
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: 1 Issue: 3 Pages: 1-6
- DOI
  10.1007/s11418-021-01502-4
- NAID
  40022591483
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0150
[Journal Article] o-Anisidine Dimer, 2-Methoxy-N4-(2-methoxyphenyl) Benzene-1,4-diamine, in Rat Urine Associated with Urinary bladder Carcinogenesis2021
- Author(s)
  Kobayashi Takuma、Toyoda Takeshi、Tajima Yuya、Kishimoto Shinji、Tsunematsu Yuta、Sato Michio、Matsushita Kohei、Yamada Takanori、Shimamura Yuko、Masuda Shuichi、Ochiai Masako、Ogawa Kumiko、Watanabe Kenji、Takamura-Enya Takeji、Totsuka Yukari、Wakabayashi Keiji、Miyoshi Noriyuki
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 34 Issue: 3 Pages: 912-919
- DOI
  10.1021/acs.chemrestox.0c00536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07136, KAKENHI-PROJECT-20K05866, KAKENHI-PROJECT-20K10452, KAKENHI-PROJECT-19H02898, KAKENHI-PROJECT-19K12344, KAKENHI-PROJECT-20H04109
[Journal Article] Isolation of New Colibactin Metabolites from Wild-Type Escherichia coli and In Situ Trapping of a Mature Colibactin Derivative2021
- Author(s)
  Zhou Tao、Hirayama Yuichiro、Tsunematsu Yuta、Suzuki Nanami、Tanaka Seiji、Uchiyama Nahoko、Goda Yukihiro、Yoshikawa Yuko、Iwashita Yuji、Sato Michio、Miyoshi Noriyuki、Mutoh Michihiro、Ishikawa Hideki、Sugimura Haruhiko、Wakabayashi Keiji、Watanabe Kenji
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 143 Issue: 14 Pages: 5526-5533
- DOI
  10.1021/jacs.1c01495
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05866, KAKENHI-PROJECT-19K07136, KAKENHI-PROJECT-19H02898
[Journal Article] Elevated levels of proinflammatory volatile metabolites in feces of high fat diet fed KK-Ay mice2020
- Author(s)
  Uchikawa Misaki、Kato Mai、Nagata Akika、Sanada Shunsuke、Yoshikawa Yuto、Tsunematsu Yuta、Sato Michio、Suzuki Takuji、Hashidume Tsutomu、Watanabe Kenji、Yoshikawa Yuko、Miyoshi Noriyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 5681-5681
- DOI
  10.1038/s41598-020-62541-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H03041, KAKENHI-PROJECT-18K11123, KAKENHI-PROJECT-19K07136, KAKENHI-PROJECT-20K05866, KAKENHI-PROJECT-17K08841
[Journal Article] ディールス－アルダラーゼとはどういった酵素なのか？2020
- Author(s)
  佐藤道大、渡辺賢二
- Journal Title
  
  化学
  
  Volume: 76 Pages: 72-73
- Data Source
  KAKENHI-PROJECT-19KK0150
[Journal Article] Genotyping of a gene cluster for production of colibactin and in vitro genotoxicity analysis of Escherichia coli strains obtained from the Japan Collection of Microorganisms2020
- Author(s)
  Kawanishi Masanobu、Shimohara Chiaki、Oda Yoshimitsu、Hisatomi Yuuta、Tsunematsu Yuta、Sato Michio、Hirayama Yuichiro、Miyoshi Noriyuki、Iwashita Yuji、Yoshikawa Yuko、Sugimura Haruhiko、Mutoh Michihiro、Ishikawa Hideki、Wakabayashi Keiji、Yagi Takashi、Watanabe Kenji
- Journal Title
  
  Genes and Environment
  
  Volume: 42 Issue: 1 Pages: 12-17
- DOI
  10.1186/s41021-020-00149-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18J02190, KAKENHI-PROJECT-19K07136, KAKENHI-PROJECT-20K05866, KAKENHI-PROJECT-19H02898, KAKENHI-PROJECT-17K08841
[Journal Article] Artesunate Inhibits Intestinal Tumorigenesis through Inhibiting Wnt Signaling.2020
- Author(s)
  Hamoya T, Fujii G, Iizumi Y, Narita T, Komiya M, Matsuzawa Y, Miki K, Kondo T, Kishimoto S, Watanabe K, Wakabayashi K, Sakai T, Toshima J, Mutoh M
- Journal Title
  
  Carcinogenesis
  
  Volume: 42 Issue: 1 Pages: 148-58
- DOI
  10.1093/carcin/bgaa084
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11066, KAKENHI-PROJECT-19K06571, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06398, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-19H02898, KAKENHI-PROJECT-19J10184
[Journal Article] A new class of dimeric product isolated from the fungus Chaetomium globosum: evaluation of chemical structure and biological activity2020
- Author(s)
  Sarmales-Murga Christopher、Akaoka Fumito、Sato Michio、Takanishi Jun、Mino Takashi、Miyoshi Noriyuki、Watanabe Kenji
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 73 Issue: 5 Pages: 320-323
- DOI
  10.1038/s41429-020-0281-x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-19K07136
[Journal Article] Biosynthesis of the Immunosuppressant (?)-FR9014832020
- Author(s)
  Zhang Zhuan、Tamura Yui、Tang Mancheng、Qiao Tianzhang、Sato Michio、Otsu Yoshihiro、Sasamura Satoshi、Taniguchi Masatoshi、Watanabe Kenji、Tang Yi
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 143 Issue: 1 Pages: 132-136
- DOI
  10.1021/jacs.0c12352
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07136, KAKENHI-PROJECT-19KK0150, KAKENHI-PLANNED-16H06449
[Journal Article] Oxidative modification enzymes in polyketide biosynthetic pathways2020
- Author(s)
  Tsunematsu, Y., Hirayama, Y., Masuya, T., Watanabe, K.
- Journal Title
  
  Comprehensive Natural Products III: Chemistry and Biology, Wiley
  
  Volume: 4 Pages: 30-30
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06449
[Journal Article] Concise Biosynthesis of Phenylfuropyridones in Fungi2020
- Author(s)
  Zhang Zhuan、Qiao Tianzhang、Watanabe Kenji、Tang Yi
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 59 Issue: 45 Pages: 19889-19893
- DOI
  10.1002/anie.202008321
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Journal Article] Specialized Flavoprotein Promotes Sulfur Migration and Spiroaminal Formation in Aspirochlorine Biosynthesis2020
- Author(s)
  Tsunematsu Yuta、Maeda Naoya、Sato Michio、Hara Kodai、Hashimoto Hiroshi、Watanabe Kenji、Hertweck Christian
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 143 Issue: 1 Pages: 206-213
- DOI
  10.1021/jacs.0c08879
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07136, KAKENHI-PROJECT-20K05866, KAKENHI-PROJECT-19KK0150, KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-20H03197, KAKENHI-PROJECT-17K07314
[Journal Article] Bisindole2020
- Author(s)
  Sato, M., Kishimoto, S., Noguchi, H., Watanabe, K.
- Journal Title
  
  Comprehensive Natural Products III: Chemistry and Biology, Wiley
  
  Volume: 4 Pages: 1-1
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06449
[Journal Article] Uncovering hidden sesquiterpene biosynthetic pathway through expression boost area-mediated productivity enhancement in basidiomycete2020
- Author(s)
  Asai Shihori、Tsunematsu Yuta、Masuya Takahiro、Otaka Junnosuke、Osada Hiroyuki、Watanabe Kenji
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 73 Issue: 10 Pages: 721-728
- DOI
  10.1038/s41429-020-0355-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05866, KAKENHI-PROJECT-20K15457, KAKENHI-PLANNED-16H06449, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18H03945
[Journal Article] Biosynthesis of lagopodins in mushroom involves a complex network of oxidation reactions2019
- Author(s)
  Masuya Takahiro、Tsunematsu Yuta、Hirayama Yuichiro、Sato Michio、Noguchi Hiroshi、Nakazawa Takehito、Watanabe Kenji
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 17 Issue: 2 Pages: 234-239
- DOI
  10.1039/c8ob02814a
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-16H05840, KAKENHI-PROJECT-17H07002, KAKENHI-PROJECT-17K15265
[Journal Article] In vitro genotoxicity analyses of colibactin-producing E. coli isolated from a Japanese colorectal cancer patient2019
- Author(s)
 Kawanishi Masanobu、Hisatomi Yuuta、Oda Yoshimitsu、Shimohara Chiaki、Tsunematsu Yuta、Sato Michio、Hirayama Yuichiro、Miyoshi Noriyuki、Iwashita Yuji、Yoshikawa Yuko、Sugimura Haruhiko、Mutoh Michihiro、Ishikawa Hideki、Wakabayashi Keiji、Yagi Takashi、Watanabe Kenji
- Journal Title
 
 The Journal of Toxicological Sciences
 
 Volume: 44 Issue: 12 Pages: 871-876
- DOI
 10.2131/jts.44.871
- NAID
 130007759775
- ISSN
 0388-1350, 1880-3989
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-17K08841, KAKENHI-PROJECT-19H02898, KAKENHI-PROJECT-18J02190
[Journal Article] Activity-Based Probe for Screening of High-Colibactin Producers from Clinical Samples2019
- Author(s)
  Hirayama Yuichiro、Tsunematsu Yuta、Yoshikawa Yuko、Tamafune Ryota、Matsuzaki Nobuo、Iwashita Yuji、Ohnishi Ippei、Tanioka Fumihiko、Sato Michio、Miyoshi Noriyuki、Mutoh Michihiro、Ishikawa Hideki、Sugimura Haruhiko、Wakabayashi Keiji、Watanabe Kenji
- Journal Title
  
  Organic Letters
  
  Volume: 21 Issue: 12 Pages: 4490-4494
- DOI
  10.1021/acs.orglett.9b01345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08841, KAKENHI-PROJECT-19H02898, KAKENHI-PROJECT-18J02190
[Journal Article] Genomic Mushroom Hunting Decrypts Coprinoferrin, A Siderophore Secondary Metabolite Vital to Fungal Cell Development2019
- Author(s)
  Tsunematsu Yuta、Takanishi Jun、Asai Shihori、Masuya Takahiro、Nakazawa Takehito、Watanabe Kenji
- Journal Title
  
  Organic Letters
  
  Volume: 21 Issue: 18 Pages: 7582-7586
- DOI
  10.1021/acs.orglett.9b02861
- NAID
  40022757906
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19KK0150, KAKENHI-PLANNED-16H06449
[Journal Article] Functional and Structural Analyses of trans C-Methyltransferase in Fungal Polyketide Biosynthesis2019
- Author(s)
  Kishimoto Shinji、Tsunematsu Yuta、Matsushita Takuma、Hara Kodai、Hashimoto Hiroshi、Tang Yi、Watanabe Kenji
- Journal Title
  
  Biochemistry
  
  Volume: 58 Issue: 38 Pages: 3933-3937
- DOI
  10.1021/acs.biochem.9b00702
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07314, KAKENHI-PROJECT-19K15757, KAKENHI-PROJECT-19KK0150, KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-16H05840
[Journal Article] Polyketide synthase-nonribosomal peptide synthetase hybrid enzymes of fungi2018
- Author(s)
  Kishimoto, S., Hirayama, Y., Watanabe, K.
- Journal Title
  
  The Mycota XV: Physiology and Genetics
  
  Volume: 368 Pages: 1-1
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06449
[Journal Article] Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids2018
- Author(s)
  Li Li、Tang Man-Cheng、Tang Shoubin、Gao Shushan、Soliman Sameh、Hang Leibniz、Xu Wei、Ye Tao、Watanabe Kenji、Tang Yi
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 140 Issue: 6 Pages: 2067-2071
- DOI
  10.1021/jacs.8b00056
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Journal Article] Enzymatic Amide Tailoring Promotes Retro-Aldol Amino Acid Conversion To Form the Antifungal Agent Aspirochlorine2018
- Author(s)
  Tsunematsu Yuta、Maeda Naoya、Yokoyama Mamoru、Chankhamjon Pranatchareeya、Watanabe Kenji、Scherlach Kirstin、Hertweck Christian
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 57 Issue: 43 Pages: 14051-14054
- DOI
  10.1002/anie.201806740
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-17K15265
[Journal Article] Enzymatic one-step ring contraction for quinolone biosynthesis2018
- Author(s)
  Kishimoto Shinji、Hara Kodai、Hashimoto Hiroshi、Hirayama Yuichiro、Champagne Pier Alexandre、Houk Kendall N.、Tang Yi、Watanabe Kenji
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 2826-2826
- DOI
  10.1038/s41467-018-05221-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07314, KAKENHI-PLANNED-16H06449, KAKENHI-PUBLICLY-17H06014, KAKENHI-PROJECT-16H04755, KAKENHI-PROJECT-16H05113, KAKENHI-PROJECT-16H05840
[Journal Article] Integration of chemical, genetic and bioinformatic approaches delineates fungal polyketide-peptide hybrid biosynthesis.2017
- Author(s)
  Yokoyama, M., Hirayama, Y., Yamamoto, T., Kishimoto, S., Tsunematsu, Y., Watanabe, K.
- Journal Title
  
  Org. Lett.
  
  Volume: 印刷中 Issue: 8 Pages: 2002-2005
- DOI
  10.1021/acs.orglett.7b00559
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-16H06449
[Journal Article] Elucidation of biosynthetic pathways of natural products.2017
- Author(s)
  Kishimoto, S., Tsunematsu, Y., Sato, M., Watanabe, K.
- Journal Title
  
  The Chemical Record
  
  Volume: 印刷中 Issue: 11 Pages: 1095-1108
- DOI
  10.1002/tcr.201700015
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-15KT0068, KAKENHI-PROJECT-17K15265
[Journal Article] Oxidative Cyclization in Natural Product Biosynthesis2017
- Author(s)
  Tang Man-Cheng、Zou Yi、Watanabe Kenji、Walsh Christopher T.、Tang Yi
- Journal Title
  
  Chemical Reviews
  
  Volume: 117 Issue: 8 Pages: 5226-5333
- DOI
  10.1021/acs.chemrev.6b00478
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Journal Article] Collaborative biosynthesis of maleimide- and succinimide- containing natural products by fungal polyketide megasynthases.2017
- Author(s)
  Sato, M., Dander, J. E., Sato, C., Hung, Y.-S., Gao, S.-S., Tang, M.-C., Hang, L., Winter, J. M., Garg, N. K.*, Watanabe, K.*, Tang, Y.*
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 印刷中 Issue: 15 Pages: 5317-5320
- DOI
  10.1021/jacs.7b02432
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KT0068
[Journal Article] SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis2017
- Author(s)
  1.Ohashi, M., Liu, F., Hai, Y., Chen, M., Tang, M.-C., Yang, Z., Sato, M., Watanabe, K., Houk, K. N., Tang, Y.
- Journal Title
  
  Nature
  
  Volume: 549 Issue: 7673 Pages: 502-506
- DOI
  10.1038/nature23882
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Journal Article] Integration of Chemical, Genetic, and Bioinformatic Approaches Delineates Fungal Polyketide-Peptide Hybrid Biosynthesis2017
- Author(s)
  Yokoyama M, Hirayama Y, Yamamoto T, Kishimoto S, Tsunematsu Y, Watanabe K
- Journal Title
  
  Org Lett
  
  Volume: 19 Pages: 2002-2005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Journal Article] Biochemical characterization of an eukaryotic decalin-forming Diels-Alderase.2016
- Author(s)
  Li, L., Yu, P., Tang, M. C., Zou, Y., Gao, S.-S., Hung, Y.-S., Zhao, M., Watanabe, K., Houk, K., Tang, Y.
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 138 Issue: 49 Pages: 15837-15840
- DOI
  10.1021/jacs.6b10452
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-15KT0068
[Journal Article] Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis2016
- Author(s)
  Tsuyoshi Yamamoto, Yuta Tsunematsu, Kodai Hara, Tomohiro Suzuki, Shinji Kishimoto, Hirokazu Kawaguchi, Hiroshi Noguchi, Hiroshi Hashimoto, Yi Tang, Kinya Hotta, & Kenji Watanabe
- Journal Title
  
  Angew Chem Int Ed Engl
  
  Volume: 印刷中 Issue: 21 Pages: 6207-6210
- DOI
  10.1002/anie.201600940
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25291017, KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-16H05840, KAKENHI-PROJECT-15K18491, KAKENHI-PROJECT-16K00397, KAKENHI-PROJECT-16H04755
[Journal Article] Oxidative trans-to-cis isomerization of olefin in polyketide biosynthesis.2016
- Author(s)
  Yamamoto, T., Tsunematsu, Y., Hara, K., Suzuki, T., Kishimoto, S., Kawagishi, H., Noguchi, H., Hashimoto, H., Tang, Y., Hotta, K., Watanabe, K.
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 55
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KT0068
[Journal Article] Regioselective dichlorination of a non-activated aliphatic carbon and phenol bismethylation by a multifunctional fungal flavoenzyme.2016
- Author(s)
  Chankhamjon, P., Tsunematsu, Y., Ishida-Ito, M., Sasa, Y., Meyer, F., Boettger-Schmidt, D., Urbansky, B., Menzel, K. D., Scherlach, K., Watanabe, K., Hertweck, C.
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 55 Issue: 39 Pages: 11955-11959
- DOI
  10.1002/anie.201604516
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Journal Article] Activation of transient receptor potential ankyrin 1 by quercetin and its analogs.2016
- Author(s)
  Toshiyuki Nakamura, Noriyuki Miyoshi, Takeshi Ishii, Miyu Nishikawa, Shinichi Ikushiro, Tatsuo Watanabe
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 80 Issue: 5 Pages: 949-954
- DOI
  10.1080/09168451.2015.1132148
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K16212, KAKENHI-PROJECT-24300252, KAKENHI-PROJECT-26292072, KAKENHI-PROJECT-16H03041, KAKENHI-PROJECT-16K12726
[Journal Article] Combinatorial Generation of Chemical Diversity by Redox Enzymes in Chaetoviridin Biosynthesis2016
- Author(s)
  Sato M, Winter JM, Kishimoto S, Noguchi H, Tang Yi, Watanabe K
- Journal Title
  
  Org. Lettr
  
  Volume: 18 Issue: 6 Pages: 1446-1449
- DOI
  10.1021/acs.orglett.6b00380
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05840, KAKENHI-PROJECT-15KT0068
[Journal Article] Elucidation of Pyranonigrin Biosynthetic Pathway Reveals a Mode of Tetramic Acid, Fused γ-Pyrone, and exo-Methylene Formation.2015
- Author(s)
  Yamamoto, T., Tsunematsu, Y., Noguchi, H., Hotta, K., Watanabe, K.
- Journal Title
  
  Org. Lett.
  
  Volume: 17 Issue: 20 Pages: 4992-4995
- DOI
  10.1021/acs.orglett.5b02435
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KT0068
[Journal Article] Elucidation of shanorellin biosynthetic pathway and functional analysis of associated enzymes.2015
- Author(s)
  Sato, M., Yamada, H., Hotta, K., Watanabe, K.
- Journal Title
  
  MedChemComm
  
  Volume: 6 Issue: 3 Pages: 425-430
- DOI
  10.1039/c4md00352g
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670048
[Journal Article] Tandem prenyltransferases catalyze isoprenoid elongation and complexity generation in biosynthesis of quinolone alkaloids.2015
- Author(s)
  Zou, Y., Zhan, Z., Li, D., Tang, M., Watanabe, K., Tang, Y.
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 137 Issue: 15 Pages: 4980-4983
- DOI
  10.1021/jacs.5b03022
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26560450
[Journal Article] Biochemical and structural basis for controlling chemical modularity in fungal polyketide biosynthesis.2015
- Author(s)
  Winter, J. M., Cascio, D., Dietrich, D., Sato, M., Watanabe, K., Sawaya, M., Vederas, J. C., Tang, Y.
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 137 Issue: 31 Pages: 9885-9893
- DOI
  10.1021/jacs.5b04520
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26560450
[Journal Article] Combinatorial generation of complexity by redox enzymes in the chaetoglobosin a biosynthesis2013
- Author(s)
  K. Ishiuchi, T. Nakazawa, F. Yagishita, T. Mino, H. Noguchi, K. Hotta, K. Watanabe
- Journal Title
  
  J. Am. Chem. Soc
  
  Volume: 135 Pages: 7371-7377
- Data Source
  KAKENHI-PROJECT-22241054
[Journal Article] Targeted disruption of transcriptional regulators in Chaetomium globosum activates biosynthetic pathways and reveals transcriptional regulator-like behavior of aureonitol.2013
- Author(s)
  Nakazawa T, et al.
- Journal Title
  
  J. Am. Chem. Soc
  
  Volume: 135 Issue: 36 Pages: 13446-13455
- DOI
  10.1021/ja405128k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23406031, KAKENHI-PROJECT-25242067
[Journal Article] Combinatorial Generation of Complexity by Redox Enzymes in the Chaetoglobosin A Biosynthesis2013
- Author(s)
  K. Ishiuchi, T. Nakazawa, F. Yagishita, T. Mino, H. Noguchi, K.a Hotta, K. Watanabe
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 135 Issue: 19 Pages: 7371-7377
- DOI
  10.1021/ja402828w
- URL
  http://dx.doi.org/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241054, KAKENHI-PROJECT-23406031, KAKENHI-PROJECT-23880025, KAKENHI-PROJECT-25242067
[Journal Article] Spiro-carbon formation by different chemistry involving pathway crosstalk.2013
- Author(s)
  石川格靖, 他8名
- Journal Title
  
  Nature Chemical Biology
  
  Volume: 9 Issue: 12 Pages: 818-825
- DOI
  10.1038/nchembio.1366
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J10688, KAKENHI-PROJECT-23310140, KAKENHI-PROJECT-23406031, KAKENHI-PUBLICLY-25108717, KAKENHI-PROJECT-25242067, KAKENHI-PROJECT-25640115
[Journal Article] Establishing a new methodology for genome mining and biosynthesis of polyketides and peptides through yeast molecular genetics2012
- Author(s)
  K. Ishiuchi, T. Nakazawa, T. Ookuma, S. Sugimoto, M. Sato, Y. Tsunematsu, N. Ishikawa, H. Noguchi, K. Hotta, H. Moriya, K. Watanabe
- Journal Title
  
  ChemBioChem
  
  Volume: 13(6) Pages: 846-854
- Data Source
  KAKENHI-PROJECT-22241054
[Journal Article] Overexpressing transcriptional regulator in Aspergillus oryzae activates a silent biosynthetic pathway to produce novel polyketide2012
- Author(s)
  T. Nakazawa, K. Ishiuchi, A. Praseuth, H. Noguchi, K. Hotta, K. Watanabe
- Journal Title
  
  ChemBioChem
  
  Volume: 13(6) Pages: 855-861
- Data Source
  KAKENHI-PROJECT-22241054
[Journal Article] Development of EST-SSR markers of Ipomoea nil2012
- Author(s)
 T. Ly, H. Fukuoka, A. Otaka, A. Hoshino, S. Iida, E. Nitasaka, N. Watanabe and T. Kuboyama
- Journal Title
 
 Breeding Science
 
 Volume: 62 Issue: 1 Pages: 99-104
- DOI
 10.1270/jsbbs.62.99
- NAID
 130004146342
- ISSN
 1344-7610, 1347-3735
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-22370001, KAKENHI-PROJECT-22770047, KAKENHI-PROJECT-24501059
[Journal Article] Establishing a new methodology for genome mining and biosynthesis of polyketides and peptides through yeast molecular genetics2012
- Author(s)
  Ishiuchi, K., Nakazawa, T., Ookuma, T., Sugimoto, T., Sato, M., Tsunematsu, Y., Ishikawa, N., Noguchi, H., Hotta, K., Moriya, H., Watanabe, K.
- Journal Title
  
  ChemBioChem
  
  Volume: 13 Pages: 846-854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241054
[Journal Article] Overexpressing transcriptional regulator in Aspergillus oryzae activates a silent biosynthetic pathway to produce novel polyketide2012
- Author(s)
  Nakazawa, T., Ishiuchi, K., Praseuth, A., Noguchi, H., Hotta, K., Moriya, H., Watanabe, K.
- Journal Title
  
  ChemBioChem
  
  Volume: 13 Pages: 855-861
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241054
[Journal Article] Overexpressing transcriptional regulator in Chaetomium globosum activates a silent biosynthetic pathway: evaluation of shanorellin biosynthesis2012
- Author(s)
  Y. Tsunematsu, S. Ichinoseki, T. Nakazawa, N. Ishikawa, H. Noguchi, K. Hotta, K. Watanabe
- Journal Title
  
  J. of Antibiotics
  
  Volume: 65(7) Pages: 377-380
- NAID
  10030955543
- Data Source
  KAKENHI-PROJECT-22241054
[Journal Article] Overexpressing transcriptional regulator in Aspergillus oryzae activates a silent biosynthetic pathway to produce novel polyketide2012
- Author(s)
  T. Nakazawa, K. Ishiuchi, A. Praseuth, H. Noguchi, K. Hotta, K. Watanabe
- Journal Title
  
  ChemBioChem.
  
  Volume: 13(6) Issue: 6 Pages: 855-861
- DOI
  10.1002/cbic.201200107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241054, KAKENHI-PROJECT-23406031, KAKENHI-PROJECT-23880025
[Journal Article] Establishing a New Methodology for Genome Mining and Biosynthesis of Polyketides and Peptides through Yeast Molecular Genetics2012
- Author(s)
  石内勘一郎、佐藤道大, 他9名
- Journal Title
  
  Chembiochem
  
  Volume: 13 Issue: 6 Pages: 846-854
- DOI
  10.1002/cbic.201100798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J01668, KAKENHI-PROJECT-22241054, KAKENHI-PROJECT-23310140, KAKENHI-PROJECT-23406031, KAKENHI-PROJECT-23880025
[Journal Article] A comprehensive overview on genomically directed assembly of aromatic polyketides and macrolide lactones using fungal megasynthases2011
- Author(s)
  Saruwatari, T., Praseuth, A.P., Sato, M., Torikai, K., Noguchi, H., Watanabe, K.
- Journal Title
  
  J.Antibiot.
  
  Volume: 64 Pages: 9-17
- NAID
  10030637198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241054
[Journal Article] A comprehensive overview on genomically directed assembly of aromatic polyketides and macrolide lactones using fungal megasynthases2011
- Author(s)
  T. Saruwatari, A. P Praseuth, M. Sato, K. Torikai, H. Noguchi, K. Watanabe
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 64 Pages: 9-17
- NAID
  10030637198
- Data Source
  KAKENHI-PROJECT-22241054
[Journal Article] Practical Synthesis of dopa derivative for biosynthetic production of potent antitumor natural products, Saframycins and Ecteinascidin 7432011
- Author(s)
  K. Torikai, T. Saruwatari, T. Kitano, T. Sano, A. Nakane, H. Noguchi, K. Watanabe
- Journal Title
  
  Letters In Organic Chemistry
  
  Volume: 8-10 Pages: 686-689
- NAID
  120005133055
- Data Source
  KAKENHI-PROJECT-22241054
[Journal Article] 生合成マシナリーを用いた抗腫瘍性物質生産の試み2011
- Author(s)
  渡辺賢二
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 69 Pages: 26-30
- NAID
  10027617152
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] A comprehensive overview on genomically directed assembly of aromatic polyketides and macrolide lactones using fungal megasynthases2011
- Author(s)
  T.Saruwatari, A.P Praseuth, M.Sato, K.Torikai, H.Noguchi, K.Watanabe
- Journal Title
  
  Journal of Antibiotics
  
  Volume: 64 Pages: 9-17
- NAID
  10030637198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241054
[Journal Article] Practical synthesis of DOPA derivative for biosynthetic production of potent antitumor natural products, saframycins and ecteinascidin 7432011
- Author(s)
  Torikai, K., Saruwatari, T., Kitano, T., Sano, T., Nakane, A., Noguchi, H., Watanabe, K.
- Journal Title
  
  Letters In Organic Chemistry
  
  Volume: 8 Pages: 686-689
- NAID
  120005133055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241054
[Journal Article] 生合成マシナリーを用いた抗腫瘍性物質生産の試み,バイオサイエンスとインダストリー2011
- Author(s)
  渡辺賢二, 大栗博毅, 及川英秋
- Journal Title
  
  バイオインダストリー協会 69
  
  Pages: 26-30
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms.2010
- Author(s)
  Koketsu, K., Oguri, H., Watanabe, K., Oikawa, H.
- Journal Title
  
  Nature Chemical Biology 6
  
  Pages: 408-410
- NAID
  120002646838
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Intriguing substrate tolerance of epoxide hydrolase Lsd19 involved in biosynthesis of the ionophore antibiotic lasalocid A.2010
- Author(s)
  Matsuura, Y., Shichijo, Y., Minami, A., Migita, A., Oguri, H., Watanabe, M., Tokiwano, T., Watanabe, K., Oikawa, H.
- Journal Title
  
  Org.Lett. 12
  
  Pages: 2226-2229
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Plasmid construction using recombination activity in the fission yeast Schizosaccharomyces pombe.2010
- Author(s)
  Chino, A., Watanabe, K., Moriya, M.
- Journal Title
  
  PLoS One 5
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Identification of a gene cluster of polyether antibiotic lasalocid from Streptomyces lasaliensis.2009
- Author(s)
  Migita, A., Watanabe, M., Hirose, Y., Watanabe, K., Tokiwano, T., Kinashi, H., Oikawa, H.
- Journal Title
  
  Biosci.Biotechnol.Biochem. 73
  
  Pages: 169-176
- NAID
  10027536367
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Enzymatic synthesis of molecular skeletons of complex antitumor antibiotics with non-ribosomal peptide synthetases.2009
- Author(s)
  Watanabe, K., Oguri, H, Oikawa, H.
- Journal Title
  
  Journal of Synthetic Organic Chemistry,Japan 67
  
  Pages: 1152-1160
- NAID
  10026866717
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product.2009
- Author(s)
  Watanabe, K., Hotta, K., Nakaya, M., Praseuth, A.P., Wang, C.C.C., Inada, D., Takahashi, K., Fukushi, F., Oguri, H., Oikawa, H.
- Journal Title
  
  J.Am.Chem.Soc. 131
  
  Pages: 9347-9353
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural product2009
- Author(s)
  Watanabe, K., et al.
- Journal Title
  
  J Am Chem Soc 131
  
  Pages: 9347-9353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Genetic indoctrination of Escherichia coli for innovative drug discovery by way of heterologous expression of the echinomycin biosynthetic pathway.2009
- Author(s)
  Watanabe, K., Oguri, H., Oikawa, H.
- Journal Title
  
  Current Opinion in Chemical Biology 13
  
  Pages: 189-196
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Sequence and analysis of the SF2575 gene cluster and characterization of key tailoring enzyme.2009
- Author(s)
  Pickens, L.B., Wang, P., Zhou, H., Kim, W., Watanabe, K., Gomi, S., Tang, Y.
- Journal Title
  
  J.Am.Chem.Soc. 131
  
  Pages: 17677-17689
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Rationally engineered total biosynthesis of a synthetic analogue of natural quinomycin depsipeptide in Escherichia coli2009
- Author(s)
  Watanabe, K., et al.
- Journal Title
  
  ChembioChem 10
  
  Pages: 1965-1968
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Chromatin-level regulation of biosynthetic gene clusters.2009
- Author(s)
  Bok, J.W., Chiang, Y. M., Szewczyk, E., Reyes-Domingez, Y., Davidson, A.D., Sanchez, J.F., Lo, H.C., Watanabe, K., Strauss, J., Oakley, B.R., Wang, C.C.C., Keller, N.P.
- Journal Title
  
  Nature Chemical Biology 5
  
  Pages: 462-464
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Rationally Engineered Total Biosynthesis of a Synthetic Analog of a Natural Quinomycin Depsipeptide in Escherichia coli.2009
- Author(s)
  Watanabe, K., Hotta, K., Praseuth, A.P., Searcey, M., Wang, C.C.C., Oguri, H., Oikawa, H.
- Journal Title
  
  ChemBioChem 10
  
  Pages: 1965-1968
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Involvement of common intermediate L-3-hydroxyknyurenine in the chromophore biosynthesis of quinomycin family antibiotics.
- Author(s)
  Hirose, Y., Watanabe, K., Minami, A., Nakamura, T., Oguri, H., Oikawa, H.
- Journal Title
  
  J.Antibiot. in press.
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] A comprehensive overview on genomically directed assembly of aromatic polyketides and macrolide lactones using fungal megasynthases.
- Author(s)
  Saruwatari, T., Praseuth, A. P., Sato, M., Torikai, K., Noguchi, H., Watanabe, K.
- Journal Title
  
  J.Antibiot. in press.
- NAID
  10030637198
- Data Source
  KAKENHI-PROJECT-21780106
[Patent] プロバイオティクス大腸菌の二重変異株、該二重変異株から産生される膜小胞、及びそれを用いた製品2024
- Inventor(s)
  中尾龍馬、安部公博、尾花望、渡辺賢二
- Industrial Property Rights Holder
  国立感染症研究所長
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2024-033964
- Filing Date
  2024
- Data Source
  KAKENHI-PROJECT-22H04979
[Patent] コリバクチン産生大腸菌結合性抗体2023
- Inventor(s)
  渡辺賢二、瀧本陽介
- Industrial Property Rights Holder
  株式会社アデノプリベント、静岡県公立大学法人
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-22H04979
[Patent] PCT出願2022
- Inventor(s)
  周韜、渡辺賢二
- Industrial Property Rights Holder
  周韜、渡辺賢二
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-19H02898
[Patent] コリバクチンおよびコリバクチン産生菌の検出方法および検出プローブ2022
- Inventor(s)
  渡辺賢二、恒松雄太、佐藤道大
- Industrial Property Rights Holder
  静岡県公立大学法人
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Acquisition Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-22H04979
[Patent] コリバクチン産生菌検出用プライマーセット及び検出用キット2019
- Inventor(s)
  渡辺賢二
- Industrial Property Rights Holder
  渡辺賢二
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-027695
- Filing Date
  2019
- Data Source
  KAKENHI-PLANNED-16H06449
[Patent] コリバクチンおよびコリバクチン産生菌の検出方法および検出プローブ2018
- Inventor(s)
  渡辺賢二
- Industrial Property Rights Holder
  渡辺賢二
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PLANNED-16H06449
[Patent] カビ類ポリケチド合成遺伝子の酵母での異種発現2010
- Inventor(s)
  渡辺賢二, 守屋央朗
- Industrial Property Rights Holder
  静岡県立大学, 岡山大学
- Industrial Property Number
  2010-181279
- Filing Date
  2010-08-13
- Data Source
  KAKENHI-PROJECT-21780106
[Patent] カビ類ポリケチド合成遺伝子の酵母での異種発現2010
- Inventor(s)
  渡辺賢二、守屋央朗
- Industrial Property Rights Holder
  静岡県立大学、岡山大学
- Filing Date
  2010-08-13
- Data Source
  KAKENHI-PROJECT-21780106
[Presentation] OSMAC法により見出された放線菌由来天然物の生合成研究2023
- Author(s)
  小林裕輝, 遠藤瞭太, 佐藤道大, Lopez Julius, 野川俊彦, 長田裕之, 渡辺賢二
- Organizer
  日本農芸化学会2023年度大会
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] Solanoeclepin A生合成経路解明に向けたNicotiana benthamianaへの一過性異種発現における重要中間体cycloartenolおよび関連化合物の単離構造解析について2023
- Author(s)
  青木聡樹、岡本拓実、山本泰誠、岸本真治、渡辺賢二
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] CYTOCHROME P450 FOR CREATION OF DIMERIZED DIKETOPIPERAZINES2023
- Author(s)
  Micho Sato, Yuji Ogata, Kenji Watanabe
- Organizer
  International Conference on NATURAL PRODUCT DISCOVERY and DEVELOPMENT in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] マメ科モデル植物およびその近縁種を用いたダイズシストセンチュウ孵化誘因物質glycinoeclepin A の生合成遺伝子および経路の解明2023
- Author(s)
  村上侑太郎、岡本拓実、岸本真治、渡辺賢二
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] OSMAC法により見出された放線菌由来天然物の生合成研究2023
- Author(s)
  小林裕輝, 遠藤瞭太, 佐藤道大, Lopez Julius, 野川俊彦, 長田裕之, 渡辺賢二
- Organizer
  日本薬学会　第143年会
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] Structural elucidation of natural product colibactin isolated from Escherichia coli in tumor tissues of clinical samples2023
- Author(s)
  渡辺賢二
- Organizer
  4th Bandung Shizuoka Food and Pharma Conference
- Invited
- Data Source
  KAKENHI-PROJECT-22H04979
[Presentation] 天然物生合成遺伝子の発現による遺伝子治療法の確立2023
- Author(s)
  根岸天都, 恒松雄太, 佐藤道大, 渡辺賢二
- Organizer
  日本生薬学会第69回年会
- Data Source
  KAKENHI-PROJECT-22K19158
[Presentation] アズラクトン合成酵素の機能解析2023
- Author(s)
  青木義光, 南歩実, 岸本真治, 渡辺賢二
- Organizer
  日本薬学会　第143年会
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] Cladobotryum属真菌が生産するFR901483に対する自己耐性機構の解明2023
- Author(s)
  坂野桜子, 中原実玖, 田村優衣, 佐藤道大, 原幸大, 橋本博, Tang Yi, 渡辺賢二
- Organizer
  日本薬学会　第143年会
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] BIOSYNTHETIC STUDY ON FUNGAL METABOLITE, PYRROLIZILACTONE2023
- Author(s)
  Sakurako Sakano, Micho Sato, Hiroyuki Osada, Kenji Watanabe
- Organizer
  International Conference on NATURAL PRODUCT DISCOVERY and DEVELOPMENT in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] アズラクトン合成酵素の機能解析2023
- Author(s)
  青木義光, 南歩実, 岸本真治, 渡辺賢二
- Organizer
  日本農芸化学会2023年度大会
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] ClbP特異阻害剤のスクリーニング法2023
- Author(s)
  周韜, 佐藤道大, 渡辺賢二
- Organizer
  日本薬学会　第143年会
- Data Source
  KAKENHI-PROJECT-22H04979
[Presentation] 抗腫瘍性抗生物質fumagillin生合成遺伝子のウイルス発現系による新規抗がん治療法の確立2023
- Author(s)
  根岸天都, 恒松雄太, 佐藤道大, 渡辺賢二
- Organizer
  日本薬学会144年会
- Data Source
  KAKENHI-PROJECT-22K19158
[Presentation] サラシナショウマの主成分cimigenolを基点としたde novo transcriptome解析による生合成遺伝子・経路の解明2023
- Author(s)
  岡本拓実、岸本真治、渡辺賢二
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] Cladobotryum属真菌が生産するFR901483に対する自己耐性機構の解明2023
- Author(s)
  坂野桜子, 中原実玖, 田村優衣, 佐藤道大, 原幸大, 橋本博, Tang Yi, 渡辺賢二
- Organizer
  日本農芸化学会2023年度大会
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] 抗腫瘍性抗生物質fumagillin生合成遺伝子のウイルス発現系による新規抗がん遺伝子治療法の確立2023
- Author(s)
  根岸天都, 恒松雄太, 佐藤道大, 渡辺賢二
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PROJECT-22K19158
[Presentation] UNCOVERING THE SELF-RESISTANCE MECHANISM AGAINST FR901483 AS A SECONDARY METABOLITE2023
- Author(s)
  Miku Nakahara, Sakurako Sakano, Yui Tamura, Micho Sato, Kodai Hara, Hiroshi Hashimoto, Kenji Watanabe
- Organizer
  International Conference on NATURAL PRODUCT DISCOVERY and DEVELOPMENT in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] 天然物生合成研究と新展開2023
- Author(s)
  渡辺賢二
- Organizer
  第24回天然薬物の開発と応用シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22H04979
[Presentation] Ergosterolの多様な自動酸化機構の解析2023
- Author(s)
  難波良太, 岸本真治, Pengchen Ma, 西川俊夫, 及川英秋, 河岸洋和, Kendall N. Houk, 渡辺賢二
- Organizer
  日本薬学会　第143年会
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] ジャガイモシストセンチュウ孵化誘因物質solanoeclepin Aおよび類縁体の実用的供給法の構築2023
- Author(s)
  山口友喜、渡邊正悟、岡本拓実、岸本真治、渡辺賢二
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] 担子菌Coprinopsis属由来化合物lagopodin Bからhitoyol Aへの変換を担う細胞外酵素の探索2023
- Author(s)
  鈴木詞也, 浅井しほり, 遠藤瞭太, 恒松雄太, 渡辺賢二
- Organizer
  日本薬学会　第143年会
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] 抗腫瘍性抗生物質fumagillin生合成遺伝子のウイルス発現系による新規抗がん治療法の確立2023
- Author(s)
  根岸天都, 恒松雄太, 佐藤道大, 渡辺賢二
- Organizer
  第24回　天然薬物の開発と応用シンポジウム
- Data Source
  KAKENHI-PROJECT-22K19158
[Presentation] 天然物生合成研究と新展開2023
- Author(s)
  渡辺賢二
- Organizer
  第24回天然薬物の開発と応用シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] 糸状菌由来 cochliodone A 生合成におけるポリケタイド還元機構の解明2022
- Author(s)
  小坂幹, Christopher Sarmales-Murga, 佐藤道大, 渡辺賢
- Organizer
  日本生薬学会第68回年会
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] アズラクトンを経由する糸状菌二次代謝産物の生合成研究2022
- Author(s)
  南歩実, 岸本真治, 渡邉正悟, 渡辺賢二
- Organizer
  日本生薬学会第68回年会
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] Cladobotryum属真菌が生産するFR901483に対する自己耐性機構の解明2022
- Author(s)
  坂野桜子, 中原実玖, 田村優衣, 佐藤道大, 原幸大, 橋本博, Tang Yi, 渡辺賢二
- Organizer
  日本生薬学会第68回年会
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] アズラクトン合成酵素の機能解析2022
- Author(s)
  青木義光, 南歩実, 岸本真治, 渡辺賢二
- Organizer
  日本生薬学会第68回年会
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] Ergosterol 多様化鍵中間体 triradical の発見2022
- Author(s)
  難波良太, 岸本真治, Pengchen Ma, 西川俊夫, 及川英秋, 河岸洋和, Kendall N. Houk, 渡辺賢二
- Organizer
  日本生薬学会第68回年会
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] Lentopeptin A, B の生合成経路におけるジアステレオマー形成機構の解明2022
- Author(s)
  松原有也, 岸本真治, 渡辺賢二
- Organizer
  日本生薬学会第68回年会
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] アズラクトン合成酵素の機能解析2022
- Author(s)
  青木義光, 南歩実, 岸本真治, 渡辺賢二
- Organizer
  第9回食品薬学シンポジウム
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] Pyrenula sp.由来 pyrenulic acid のビスエーテル環形成メカニズム解明2022
- Author(s)
  伊藤優衣, 佐藤道大, 籠浦倫美, 石塚碧, 恒松雄太, 竹仲由希子, 棚橋孝雄, 渡辺賢二
- Organizer
  日本生薬学会第68回年会
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] Pyrenula sp.に由来する pyrenulic acid の 6,7 縮環エーテル形成機構解明2022
- Author(s)
  伊藤優衣, 佐藤道大, 籠浦倫美, 石塚碧, 恒松雄太, 竹仲由希子, 棚橋孝雄, 渡辺賢二
- Organizer
  第9回食品薬学シンポジウム
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] 反応メカニズムの理解に基づく天然物生合成リデザイン2022
- Author(s)
  渡辺賢二
- Organizer
  新学術領域研究「生合成リデザイン」取りまとめ公開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19H02898
[Presentation] 糸状菌二次代謝における隠されたアズラクトン形成の発見2022
- Author(s)
  岸本真治, 南歩実, 松原有也, 竹島実加, 渡邉正悟, 渡辺賢二
- Organizer
  第64回天然有機化合物討論会
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] Cladobotryum属真菌が生産するFR901483に対する自己耐性機構の解明2022
- Author(s)
  坂野桜子, 中原実玖, 田村優衣, 佐藤道大, 原幸大, 橋本博, Tang Yi, 渡辺賢二
- Organizer
  第9回食品薬学シンポジウム
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] 生物に作らせる未来の天然物合成化学2022
- Author(s)
  渡辺賢二
- Organizer
  日本化学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19158
[Presentation] 糸状菌Aspergillus lentulus由来新規天然物lentopeptinの発見とそのジアステレオマー形成機構解析2022
- Author(s)
  松原有也, 岸本真治, 渡辺賢二
- Organizer
  第9回食品薬学シンポジウム
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] アズラクトン形成を経由する糸状菌二次代謝産物の生合成研究2022
- Author(s)
  南歩実, 岸本真治, 渡邉正悟, 渡辺賢二
- Organizer
  第9回食品薬学シンポジウム
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] 量子化学計算を活用したergosterolの多様な自動酸化機構の解析2022
- Author(s)
  難波良太, 岸本真治, Pengchen Ma, 西川俊夫, 及川英秋, 河岸洋和, Kendall N. Houk, 渡辺賢二
- Organizer
  第9回食品薬学シンポジウム
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] 糸状菌由来 cochliodone A 生合成におけるポリケタイド還元機構の解明2022
- Author(s)
  小坂幹, Christopher Sarmales-Murga, 赤岡史人, 佐藤道大, 渡辺賢二
- Organizer
  第9回食品薬学シンポジウム
- Data Source
  KAKENHI-PLANNED-22H05121
[Presentation] Structural elucidation of natural product colibactin isolated from Escherichia coli in tumor tissues of clinical samples2021
- Author(s)
  Kenji Watanabe
- Organizer
  Pacifichem2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02898
[Presentation] Diels-Alderaseのジアステレオ選択性および生成物阻害回避メカニズムの解明2021
- Author(s)
  佐藤道大、岸本真治、Cooper S. Jamiesonc、原幸大、橋本博、恒松雄太、Houk N. Kendall、Yi Tang、渡辺賢二
- Organizer
  第62回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-19KK0150
[Presentation] ヒトがん培養細胞における天然物生合成遺伝子の機能発現2021
- Author(s)
  松田真弥、恒松雄太、松下拓磨、尾形勇二、蜂矢志保実、岸本真治、三好規之、渡辺賢二
- Organizer
  第23回天然薬物の開発と応用シンポジウム
- Data Source
  KAKENHI-PROJECT-19K22291
[Presentation] 大腸がんリスク因子コリバクチンの化学構造解析2021
- Author(s)
  周韜、平山裕一郎、恒松雄太、鈴木七海、佐藤道大、田中誠司、内山奈穂子、合田幸広、渡辺賢二
- Organizer
  第63回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-19H02898
[Presentation] 酵素的Diels-Alder反応におけるジアステレオ選択性の制御機構2020
- Author(s)
  佐藤道大, 岸本真治, Jamieson Cooper, 成田一仁, 前田直哉, 原幸大, 橋本博, 恒松雄太, Houk N. Kendall, Yi Tang, 渡辺賢二
- Organizer
  日本薬学会第140年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0150
[Presentation] Diels-Alderase CghA の全容解明2020
- Author(s)
  岸本真治, 佐藤道大, Jamieson Cooper, 横山葵, 成田一仁, 前田直哉, 恒松雄太, 原幸大, 橋本博, Houk Kendall N., 渡辺賢二
- Organizer
  日本農芸化学会2020年度大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0150
[Presentation] Diels-Alderaseのジアステレオ選択性および生成物阻害回避メカニズムの解明2020
- Author(s)
  渡辺賢二
- Organizer
  新学術領域研究「生合成リデザイン」第9回公開シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0150
[Presentation] Crystallographic characterization of Diels-Alderase binding site and mutational alteration of stereoselectivity2020
- Author(s)
  渡辺賢二
- Organizer
  Let’s leap! Challenges in Organic Chemistry
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] Diastereoselectivity of an octalin-forming Diels-Alderase2020
- Author(s)
  渡辺賢二
- Organizer
  The 10th Korea-Japan Chemical Biology Symposium and 30th Meeting for New Drug Discovery
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] Diastereoselectivity and product inhibition evasion by Diels-Alderase2020
- Author(s)
  渡辺賢二
- Organizer
  1st International Conference on Natural Product Chemistry in Taiwan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] Diels-Alderase のジアステレオ選択性および生成物阻害回避メカニズムの解明2020
- Author(s)
  佐藤道大, 岸本真治, Cooper S. Jamieson, 原幸大, 橋本博, 恒松雄太, Houk N. Kendall, Yi Tang, 渡辺賢二
- Organizer
  第62回天然有機化合物討論会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0150
[Presentation] Diels-Alderaseのジアステレオ選択性および生成物阻害回避メカニズムの解明2020
- Author(s)
  渡辺賢二
- Organizer
  生物合成系の再設計による複雑骨格機能分子の革新的創成科学、第8回公開シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] Crystallographic characterization of a [4+2]-cyclase binding site and mutational alteration of stereoselectivity2020
- Author(s)
  渡辺賢二
- Organizer
  The 2nd International Symposium on Organic Reaction Mechanism
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] 大腸がんリスク因子コリバクチン産生菌の増殖抑制を目的としたパイロット介入試験2019
- Author(s)
  渡辺賢二
- Organizer
  日本がん予防学会学
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02898
[Presentation] Crystallographic characterization of a [4+2]-cyclase binding site and mutational alteration of stereoselectivity2018
- Author(s)
  Kenji Watanabe
- Organizer
  The 2nd International Symposium on Organic Reaction Mechanism
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] Simple Screening for High-Colibactin Producers from Clinical Samples Using Activity- Based Fluorescent Probe2018
- Author(s)
  Kenji Watanabe
- Organizer
  U.S.-Japan Cooperative Medical Sciences Program (USJCMSP)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] Assay for proinflammatory activity of structurally modified lipid A.2018
- Author(s)
  Sayaka Ohashi, Tsutomu Hashidume, Noriko Ishiduka, Hisayoshi Hayashi, Yasuaki Kawarasaki, Kenji Watanabe, Yuko Yoshikawa, Noriyuki Miyoshi
- Organizer
  第23回静岡健康・長寿学術フォーラム
- Data Source
  KAKENHI-PROJECT-16H03041
[Presentation] Lipid A biosynthesis in E. coli cultured in metal-depletion2018
- Author(s)
  Sayaka Ohashi, Tsutomu Hashidume, Noriko Ishiduka, Hisayoshi Hayashi, Yasuaki Kawarasaki, Kenji Watanabe, Yuko Yoshikawa, Noriyuki Miyoshi
- Organizer
  Shizuoka ICPF 2018
- Data Source
  KAKENHI-PROJECT-16H03041
[Presentation] Simple Screening for High-Colibactin Producers from Clinical Samples Using Activity- Based Fluorescent Probe2018
- Author(s)
  Kenji Watanabe
- Organizer
  30th International Symposium on the Chemistry of Natural Products
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] ENZYMATIC ONE-STEP RING CONTRACTION FOR QUINOLONE BIOSYNTHESIS2018
- Author(s)
  Kenji Watanabe
- Organizer
  2nd China-Japan Joint Symposium on Natural Product Biosynthesis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] Simple Screening for High-Colibactin Producers from Clinical Samples Using Activity- Based Fluorescent Probe2018
- Author(s)
  Kenji Watanabe
- Organizer
  6th Biennial International Conference on New Developments in Drug Discovery from Natural Products and Traditional Medicines
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] Disfavored exo-adduct formation by a modified octalin-forming Diels-Alderase2017
- Author(s)
  渡辺賢二
- Organizer
  China/Japan Symposium on Natural Product Biosynthesis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] 実用的物質生産系構築にむけたゲノム情報に基づく新規生合成システムのリデザイ2017
- Author(s)
  渡辺賢二
- Organizer
  生物合成系の再設計による複雑骨格機能分子の革新的創成化学（新学術領域）第一回公開シンポジウム
- Place of Presentation
  東京大学, 東京
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] Genetic indoctrination of Escherichia coli for finding genotoxins “colibactin” facilitating inflammation-induced colorectal cancer2017
- Author(s)
  Kenji Watanabe
- Organizer
  US-Japan Cooperative Medical Sciences Program, 19th International Conference on Emerging Infectious Diseases in the Pacific Rim
- Place of Presentation
  Seoul, South Korea
- Year and Date
  2017-02-07
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] Disfavored exo-adduct generation by a modified octalin-forming Diels-Alderase2017
- Author(s)
  渡辺賢二
- Organizer
  Society for Industrial Microbiology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] Genetic indoctrination of Escherichia coli for finding genotoxins colibactin facilitating inflammation-induced colorectal cancer2017
- Author(s)
  渡辺賢二
- Organizer
  US-Japan Cooperative Medical Sciences Program Cancer Panel Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] 立体選択的な環化反応を触媒する酵素CghAの反応機構解析2017
- Author(s)
  横山葵, 岸本真治, 佐藤道大, 原幸大, 恒松雄太, 橋本博, 渡辺賢二
- Organizer
  日本薬学会第137年会
- Place of Presentation
  東北大学、仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15KT0068
[Presentation] 立体選択的な環化反応を触媒する酵素CghAの反応機構解析2017
- Author(s)
  横山葵, 岸本真治, 佐藤道大, 原幸大, 恒松雄太, 橋本博, ※渡辺賢二
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学、京都
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15KT0068
[Presentation] Pseurotin biosynthesis in fungus2017
- Author(s)
  渡辺賢二
- Organizer
  9th US-Japan Seminar: The international Conference of Natural Product Biosynthesis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] Genetic indoctrination of Escherichia coli for finding genotoxins “colibactin” facilitating inflammation-induced colorectal cancer2017
- Author(s)
  Kenji Watanabe
- Organizer
  U.S.-Japan Cooperative Medical Sciences Program (USJCMSP) Cancer Panel Meeting
- Place of Presentation
  Seoul, Korea
- Year and Date
  2017-02-07
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26560450
[Presentation] Novel Genotoxins “Colibactin” Produced by E.coli and colon carcinogenesis (In Vitro, In Vivo Experiments)2017
- Author(s)
  渡辺賢二
- Organizer
  The 12th international conference and 5th Asian congress on environmental mutagens with the 33rd annual meeting of KSOT/KEMS
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] 冬虫夏草Cordyceps militarisにおけるcordycepin生合成経路の研究2017
- Author(s)
  天内優子、崔宰熏、恒松雄太、渡辺賢二、道羅英夫、鈴木智大、河岸洋和
- Organizer
  日本農芸化学会
- Place of Presentation
  京都女子大学、京都
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-26670048
[Presentation] Oxidative trans-to-cis isomerization of olefin in polyketide biosynthesis2016
- Author(s)
  Kenji Watanabe
- Organizer
  The 13th International Symposium on the Genetics of Industrial Microorganisms
- Place of Presentation
  Wuhan, People’s Republic of China
- Year and Date
  2016-10-16
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] Development of catalysts from natural product biosynthesis as reagents for enzymatic syntheses of potential drugs as well as natural products2016
- Author(s)
  Kenji Watanabe
- Organizer
  Biosystems Design Symposium 2.0
- Place of Presentation
  Singapore
- Year and Date
  2016-03-21
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KT0068
[Presentation] Aspoquinolone biosynthesis: Non-heme dioxygenase catalyzes atypical oxidations of 6,7-bicycle to form 6,6-quinolone core of viridicatin-type fungal alkaloid2015
- Author(s)
  Kenji Watanabe
- Organizer
  Pacifichem 2015
- Place of Presentation
  Honolulu, Hawaii
- Year and Date
  2015-12-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KT0068
[Presentation] Elucidation of pyranonigrin biosynthetic pathway reveals mechanism of fused γ-pyrone, exo-methylene and spiral cyclobutane formation2015
- Author(s)
  Kenji Watanabe
- Organizer
  Pacifichem 2015
- Place of Presentation
  Honolulu, Hawaii
- Year and Date
  2015-12-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KT0068
[Presentation] 大腸がん原因物質コリバクチンの生合成機構の解明2015
- Author(s)
  佐々侑寿香、石川格靖、小山ふみ、福冨愛実、野口博司、渡辺賢二
- Organizer
  日本薬学会第135年会（神戸）
- Place of Presentation
  兵庫医療大学
- Year and Date
  2015-03-26
- Data Source
  KAKENHI-PROJECT-26560450
[Presentation] 大腸がん原因物質コリバクチンの生合成機構の解明2015
- Author(s)
  佐々侑寿香、石川格靖、小山ふみ、福冨愛実、野口博司、渡辺賢二
- Organizer
  日本農芸化学会2015年度大会（岡山）
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-26560450
[Presentation] Biosynthesis of a Cancer–Inducing Compound in Escherichia coli2015
- Author(s)
  Masao Oohashi, Yuzuka Sasa, Noriyasu Ishikawa, Hiroshi Noguchi and Kenji Watanabe
- Organizer
  Pacifichem 2015
- Place of Presentation
  Honolulu, Hawaii, USA.
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26560450
[Presentation] 大腸がん原因物質colibactinの化学構造解明2015
- Author(s)
  大橋雅生、渡辺賢二
- Organizer
  天然物談話会
- Place of Presentation
  宮城県岩沼市
- Year and Date
  2015-07-01
- Data Source
  KAKENHI-PROJECT-26560450
[Presentation] Natural products from fungi2013
- Author(s)
  Kenji Watanabe
- Organizer
  3rd International Conference on Natural product Biosynthesis
- Place of Presentation
  University of California Los Angeles, University of Southern California (USA)
- Invited
- Data Source
  KAKENHI-PROJECT-25242067
[Presentation] Functional reconstitution of the saframycin biosynthetic enzymes2012
- Author(s)
  K. Watanabe
- Organizer
  RCIS International Conference
- Place of Presentation
  Okayama
- Data Source
  KAKENHI-PROJECT-22241054
[Presentation] Biosynthesis of natural products through a fungal molecular genetics2012
- Author(s)
  T. Nakazawa, T. Ookuma, S. Sugimoto, S. Ichinoseki, Y. Gotanda, N. Ishikawa, Y. Tsunematsu, K. Ishiuchi, H. Noguchi, K. Watanabe
- Organizer
  Philipps-Universitat Marburg
- Place of Presentation
  Germany
- Data Source
  KAKENHI-PROJECT-22241054
[Presentation] Biologically active molecules from fungi2012
- Author(s)
  Kenji Watanabe
- Organizer
  第8回天然物生合成日米セミナー
- Place of Presentation
  淡路
- Data Source
  KAKENHI-PROJECT-22241054
[Presentation] Biosynthesis of Natural Products Through a Fungal Molecular Genetics2012
- Author(s)
  T. Nakazawa, T. Ookuma, S. Sugimoto, S. Ichinoseki, Y. Gotanda, N. Ishikawa, Y. Tsunematsu, K. Ishiuchi, H. Noguchi, K. Watanabe
- Organizer
  11th European Conference on Fungal Genetics.
- Place of Presentation
  Philipps-Universität Marburg (Germany)
- Data Source
  KAKENHI-PROJECT-22241054
[Presentation] Yeast, a more manageable non-ribosomal peptide mill for Spirotryprostatin B assembly2011
- Author(s)
  K. Watanabe
- Organizer
  11th European Conference on Fungal Genetics. Society for Industrial Microbiology, Annual meeting and exhibition 2011
- Place of Presentation
  Sheraton New Orleans, New Orleans (LA)
- Year and Date
  2011-07-24
- Data Source
  KAKENHI-PROJECT-22241054
[Presentation] T. Nakazawa, K. Ishiuchi, K. Hotta, H.Noguchi, H. Moriya, K. Watanabe2011
- Author(s)
  T. Nakazawa, K. Ishiuchi, K. Hotta, H.Noguchi, H. Moriya, K. Watanabe
- Organizer
  8th AFMC International Medicinal Chemistry Symposium "Frontier of Medicinal Science"
- Place of Presentation
  KEIO PLAZA HOTEL TOKYO(東京)
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-22241054
[Presentation] Yeast, a more manageable non-ribosomal peptide mill for Spirotryprostatin B assembly.2011
- Author(s)
  K. Watanabe
- Organizer
  International Union of Microbiological Societies 2011 Congress, Sapporo Convention Center
- Place of Presentation
  札幌
- Year and Date
  2011-09-06
- Data Source
  KAKENHI-PROJECT-22241054
[Presentation] 合理的設計に基づく改変生合成遺伝子群を用いた非天然型生物活性環状デプシペプチドの合成2010
- Author(s)
  渡辺賢二
- Organizer
  生体触媒化学シンポジウム
- Place of Presentation
  静岡市
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21780106
[Presentation] 生合成遺伝子の大腸菌発現による抗腫瘍性生理活性物質サフラマシンの効率的合成2010
- Author(s)
  渡辺賢二
- Organizer
  アステラス病態研究会
- Place of Presentation
  経団連会館,東京
- Year and Date
  2010-10-16
- Data Source
  KAKENHI-PROJECT-21780106
[Presentation] 天然物合成を指向した生合成遺伝子の異種発現によるシンセティックバイオロジーの確立2010
- Author(s)
  渡辺賢二
- Organizer
  バイオインダストリー協会
- Place of Presentation
  パシフィコ横浜,横浜
- Year and Date
  2010-09-29
- Data Source
  KAKENHI-PROJECT-21780106
[Presentation] Rational Design of Natural Products through Controlled Biosynthesis2009
- Author(s)
  Kenji Watanabe
- Organizer
  5th Japan-Korea Young Scientists Meeting on Bioorganic and Natural Products Chemistry
- Place of Presentation
  Shizuoka, JAPAN
- Data Source
  KAKENHI-PROJECT-21780106
[Presentation] Rational Design of Natural Products through Controlled BiosynthesisSociety for Industrial Microbiology2009
- Author(s)
  Kenji Watanabe
- Organizer
  Annual meeting and exhibition 2009
- Place of Presentation
  Westin Harbour Castle Hotel, Toronto, ON, Canada
- Data Source
  KAKENHI-PROJECT-21780106

1. NOGUCHI Hiroshi (60126141)

# of Collaborated Projects: 4 results

# of Collaborated Products: 17 results
2. 葛山智久 (30280952)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 山崎真巳 (70222370)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 脇本敏幸 (70363900)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. 武藤倫弘 (30392335)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. UMEHARA KAORU (40185070)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. IIDA Shigeru (30012777)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. JOHZUKA Yasuyo (60517887)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. Abe Ikuro (40305496)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 菅裕明 (00361668)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 梅野太輔 (00400812)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 南篤志 (40507191)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 濱野吉十 (50372834)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. 江口正 (60201365)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. 大利徹 (70264679)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. 池田治生 (90159632)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. 佐藤道大 (10629695)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
18. 岸本真治 (40814330)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
19. 等々力英美 (60175479)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
20. 伊藤早苗 (50610846)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
21. 名嘉地めぐみ (60632015)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
22. KINOSHITA Tetsu (60342630)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. ISHIZAKI Kimitsune (00452293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. KOBAYASHI Hirokazu (80170348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. MORITA HIROYUKI (20416663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. Miyoshi Noriyuki (70438191)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
27. 久城哲夫 (80373299)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 植木尚子 (50622023)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 恒松雄太 (30629697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
30. 朝倉敬子 (40306709)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 内山真伸 (00271916)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 丸山千登勢 (20452120)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 寺田透 (40359641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 勝山陽平 (50646437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 大栗博毅 (80311546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 淡川孝義 (80609834)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 荘司長三 (90379587)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 岡本拓実 (90885245)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
39. 國澤純 (80376615)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 椙村春彦 (00196742)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. TAMURA Kentaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. YOSHIKAWA Yuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 中潟崇

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 藤井元

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. 橋本博

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
46. 吉岡泰淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. 石川格靖

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
48. 中村俊之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. 原幸大

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
50. 山口桃生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

WATANABE KENJI 渡辺 賢二

WATANABE Kenji 渡辺 賢二

渡辺 賢二 ワタナベ ケンジ

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Toward engineered biosynthesis of drugs in human cellsPrincipal Investigator

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Uncovering a biosynthetic pathway of plant natural product solanoeclepin APrincipal Investigator

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Understanding a mechanism of an onset of colorectal cancer by colibactin and finding compounds inhibiting colibactin biosynthetic enzymesPrincipal Investigator

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Understanding a mechanism of an onset of colorectal cancer by colibactin and finding a inhibitor to the biosynthetic enzymesPrincipal Investigator

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Cell therapy by using engineered biosynthesis of anticancer agent in tumor cellsPrincipal Investigator

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Integrating Computational and Experimental Approaches for New Paradigms in Molecule SynthesisPrincipal Investigator

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Chemical characterization of colibactin and understanding a mechanism of an onset of colorectal cancer by colibactinPrincipal Investigator

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Engineered biosynthesis of new natural products for innovative drug discoveryPrincipal Investigator

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WATANABE KENJI 渡辺賢二

WATANABE Kenji 渡辺賢二

渡辺賢二ワタナベケンジ