WATANABE KENJI 渡辺賢二

… Alternative Names

Researcher Number	50360938
Other IDs
Affiliation (Current)	2020: 静岡県立大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2015 – 2020: 静岡県立大学, 薬学部, 教授 2009 – 2015: University of Shizuoka, 薬学部, 准教授 2004: 北大, (連合)農学研究科(研究院), 助手
Review Section/Research Field	Principal Investigator Science and Engineering / Chemical biology / Medium-sized Section 38:Agricultural chemistry and related fields / Applied biochemistry / Bioproduction chemistry/Bioorganic chemistry / Chemical biology / Transition State Control / Basic Section 38040:Bioorganic chemistry-related Except Principal Investigator Science and Engineering / Living organism molecular science … More
Keywords	Principal Investigator 生合成 / 天然物 / 天然物化学 / 抗生物質 / 異種発現 / ペプチド / 酵素 / 物質生産 / 遺伝子 / 大腸がん … More Except Principal Investigator 生合成 / 天然物化学 / ゲノム / 酵素工学 / バイオテクノロジー / 植物 / 反応機構 / 生合成リデザイン / 合成生物学 / 生合成工学 / 生物分子科学 / 生理活性 / biosynthesis / メロテルペノイド / 分子多様性 / テルペン環化酵素 / 酵素 / テレトニン / プレニル基転移酵素 / 分子遺伝 / 逆遺伝学 / 遺伝子 / 突然変異 / 遺伝学 / 組換え機構 / ポリケタイド / タンパク質結晶構造解析 / 閉環酵素 / X線結晶構造解析 / Type III PKS / polyketide synthase / OAC / 物質生産 / 抗生物質 / 生物活性 / 酵素化学 / 微生物 / キノコ / コルジセピン / 天然物 / 生物合成 / シアノバクテリア / 光合成細菌 / シンセティックバイオロジー / ケミカルバイオロジー / 大腸菌 / 炎症 / 分子代謝学 Less

Chemical characterization of colibactin and understanding a mechanism of an onset of colorectal cancer by colibactinPrincipal InvestigatorOngoing
- Principal Investigator
  
  渡辺賢二
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  University of Shizuoka
Cell therapy by using engineered biosynthesis of anticancer agent in tumor cellsPrincipal InvestigatorOngoing
- Principal Investigator
  
  渡辺賢二
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  University of Shizuoka
Integrating Computational and Experimental Approaches for New Paradigms in Molecule SynthesisPrincipal InvestigatorOngoing
- Principal Investigator
  
  渡辺賢二
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  University of Shizuoka
生合成リデザイン・研究総括班Ongoing
- Principal Investigator
  
  阿部郁朗
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Engineered biosynthesis of new natural products for innovative drug discoveryPrincipal InvestigatorOngoing
- Principal Investigator
  
  渡辺賢二
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  University of Shizuoka
Profiling analysis of intestinal endotoxins associated with chronic inflammation in lifestyle-related diseases
- Principal Investigator
  
  Miyoshi Noriyuki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Eating habits
- Research Institution
  University of Shizuoka
生合成リデザイン・国際活動支援班Ongoing
- Principal Investigator
  
  阿部郁朗
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Diels-Alder反応を触媒する酵素が持つ遷移状態制御の解明Principal Investigator
- Principal Investigator
  
  渡辺賢二
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Transition State Control
- Research Institution
  University of Shizuoka
Characterization of genotoxins, colibactin, facilitating inflammation-induced colorectal cancerPrincipal Investigator
- Principal Investigator
  
  Watanabe Kenji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Chemical biology
- Research Institution
  University of Shizuoka
Unprecedented enzyme-catalyzed generation of complexity in fumagillin-pseurotin biosynthesis
- Principal Investigator
  
  Noguchi Hiroshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Natural medicines
- Research Institution
  Nihon Pharmaceutical University
  University of Shizuoka
Unification of biosynthetic pathways of a variety of plant polyketides
- Principal Investigator
  
  Noguchi Hiroshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  University of Shizuoka
生合成遺伝子の異種発現によるテトラヒドロイソキノリン類の合成Principal Investigator
- Principal Investigator
  
  渡辺賢二
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  University of Shizuoka
有用天然物の生合成遺伝子発現によるシンセティックバイオロジーの確立Principal Investigator
- Principal Investigator
  
  渡辺賢二
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical biology
- Research Institution
  University of Shizuoka
病原性微生物が生産する天然物の化学構造決定および生合成機構の解明に関する研究Principal Investigator
- Principal Investigator
  
  渡辺賢二
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Chemical biology
- Research Institution
  University of Shizuoka
Generating molecular diversity by the wide range of polyketide synthases
- Principal Investigator
  
  NOGUCHI Hiroshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Living organism molecular science
- Research Institution
  University of Shizuoka
Reverse genetics and recombination
- Principal Investigator
  
  IIDA Shigeru
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Genetics/Genome dynamics
- Research Institution
  University of Shizuoka
Biosynthesis of natural antitumor agents and their rationally engineered analogs in Escherichia coliPrincipal Investigator
- Principal Investigator
  
  WATANABE Kenji
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  University of Shizuoka
セルロース有効利用を目指したセルロース分解酵素クラスターの単離および機能構築Principal Investigator
- Principal Investigator
  
  渡辺賢二
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  Hokkaido University

All 2020 2019 2018 2017 2016 2015 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book Patent

[Book] Polyketide synthase and nonribosomal peptide synthetase hybrid enzymes of fungi. The Mycota XV: Physiology and Genetics2018
- Author(s)
  Kishimoto, S., Hirayama, Y., Watanabe, K.
- Total Pages
  7
- Publisher
  Springer
- Data Source
  KAKENHI-PLANNED-16H06449
[Book] 天然物の化学Ⅱ（科学のとびら64)2018
- Author(s)
  上村大輔, 渡辺賢二
- Total Pages
  192
- Publisher
  東京化学同人
- ISBN
  9784807915057
- Data Source
  KAKENHI-PLANNED-16H06449
[Book] 天然物生合成におけるS-アデノシルメチオニン依存性酵素により触媒されるペリ環状反応2018
- Author(s)
  大橋雅生, 渡辺賢二
- Total Pages
  6
- Publisher
  現代化学
- Data Source
  KAKENHI-PLANNED-16H06449
[Book] 現代化学2017
- Author(s)
  大橋雅生, 渡辺賢二
- Total Pages
  6
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PLANNED-16H06449
[Book] BIO Clinica2017
- Author(s)
  渡辺賢二
- Total Pages
  4
- Publisher
  北隆館／ニュー・サイエンス社
- Data Source
  KAKENHI-PLANNED-16H06449
[Book] Complex enzymes : overview and peptides(Assembling nonribosomal peptide gene cluster in a heterologous host.)(edited by David Hopwood.)2009
- Author(s)
  Watanabe, K., Praseuth, A.P., Praseuth, M.B., Hotta, K.
- Publisher
  Methods in Enzymology
- Data Source
  KAKENHI-PROJECT-21780106
[Book] 天然物全合成の最新動向(生合成酵素による天然物の全合成-抗腫瘍性物質エキノマイシンの合成を中心に-)(北泰行監修)2009
- Author(s)
  渡辺賢二, 大栗博毅, 及川英秋
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Elevated levels of proinflammatory volatile metabolites in feces of high fat diet fed KK-Ay mice2020
- Author(s)
  Uchikawa Misaki、Kato Mai、Nagata Akika、Sanada Shunsuke、Yoshikawa Yuto、Tsunematsu Yuta、Sato Michio、Suzuki Takuji、Hashidume Tsutomu、Watanabe Kenji、Yoshikawa Yuko、Miyoshi Noriyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Pages: 5681-5681
- DOI
  10.1038/s41598-020-62541-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H03041
[Journal Article] A new class of dimeric product isolated from the fungus Chaetomium globosum: evaluation of chemical structure and biological activity2020
- Author(s)
  Sarmales-Murga Christopher、Akaoka Fumito、Sato Michio、Takanishi Jun、Mino Takashi、Miyoshi Noriyuki、Watanabe Kenji
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 73 Pages: 320-323
- DOI
  10.1038/s41429-020-0281-x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06449
[Journal Article] Oxidative modification enzymes in polyketide biosynthetic pathways2020
- Author(s)
  Tsunematsu, Y., Hirayama, Y., Masuya, T., Watanabe, K.
- Journal Title
  
  Comprehensive Natural Products III: Chemistry and Biology, Wiley
  
  Volume: 4 Pages: 30-30
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06449
[Journal Article] Genotyping of a gene cluster for production of colibactin and in vitro genotoxicity analysis of Escherichia coli strains obtained from the Japan Collection of Microorganisms2020
- Author(s)
  Kawanishi Masanobu、Shimohara Chiaki、Oda Yoshimitsu、Hisatomi Yuuta、Tsunematsu Yuta、Sato Michio、Hirayama Yuichiro、Miyoshi Noriyuki、Iwashita Yuji、Yoshikawa Yuko、Sugimura Haruhiko、Mutoh Michihiro、Ishikawa Hideki、Wakabayashi Keiji、Yagi Takashi、Watanabe Kenji
- Journal Title
  
  Genes and Environment
  
  Volume: 42 Pages: 12-17
- DOI
  10.1186/s41021-020-00149-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H02898, KAKENHI-PROJECT-18J02190
[Journal Article] Bisindole2020
- Author(s)
  Sato, M., Kishimoto, S., Noguchi, H., Watanabe, K.
- Journal Title
  
  Comprehensive Natural Products III: Chemistry and Biology, Wiley
  
  Volume: 4 Pages: 1-1
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06449
[Journal Article] Biosynthesis of lagopodins in mushroom involves a complex network of oxidation reactions,2019
- Author(s)
  Masuya Takahiro、Tsunematsu Yuta、Hirayama Yuichiro、Sato Michio、Noguchi Hiroshi、Nakazawa Takehito、Watanabe Kenji
- Journal Title
  
  Org Biomol Chem
  
  Volume: 17 Pages: 234-239
- DOI
  10.1039/c8ob02814a
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-17H07002, KAKENHI-PROJECT-16H05840, KAKENHI-PROJECT-17K15265
[Journal Article] In vitro genotoxicity analyses of colibactin-producing E. coli isolated from a Japanese colorectal cancer patient2019
- Author(s)
 Kawanishi Masanobu、Hisatomi Yuuta、Oda Yoshimitsu、Shimohara Chiaki、Tsunematsu Yuta、Sato Michio、Hirayama Yuichiro、Miyoshi Noriyuki、Iwashita Yuji、Yoshikawa Yuko、Sugimura Haruhiko、Mutoh Michihiro、Ishikawa Hideki、Wakabayashi Keiji、Yagi Takashi、Watanabe Kenji
- Journal Title
 
 J. Toxicol. Sci.
 
 Volume: 44 Issue: 12 Pages: 871-876
- DOI
 10.2131/jts.44.871
- ISSN
 0388-1350, 1880-3989
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-17K08841, KAKENHI-PROJECT-19H02898, KAKENHI-PROJECT-18J02190
[Journal Article] Activity-Based Probe for Screening of High-Colibactin Producers from Clinical Samples2019
- Author(s)
  Hirayama Yuichiro、Tsunematsu Yuta、Yoshikawa Yuko、Tamafune Ryota、Matsuzaki Nobuo、Iwashita Yuji、Ohnishi Ippei、Tanioka Fumihiko、Sato Michio、Miyoshi Noriyuki、Mutoh Michihiro、Ishikawa Hideki、Sugimura Haruhiko、Wakabayashi Keiji、Watanabe Kenji
- Journal Title
  
  Organic Letters
  
  Volume: 21 Pages: 4490-4494
- DOI
  10.1021/acs.orglett.9b01345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08841, KAKENHI-PROJECT-19H02898, KAKENHI-PROJECT-18J02190
[Journal Article] Genomic Mushroom Hunting Decrypts Coprinoferrin, A Siderophore Secondary Metabolite Vital to Fungal Cell Development2019
- Author(s)
  Tsunematsu Yuta、Takanishi Jun、Asai Shihori、Masuya Takahiro、Nakazawa Takehito、Watanabe Kenji
- Journal Title
  
  Organic Letters
  
  Volume: 21 Pages: 7582-7586
- DOI
  10.1021/acs.orglett.9b02861
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19KK0150, KAKENHI-PLANNED-16H06449
[Journal Article] Functional and Structural Analyses of trans C-Methyltransferase in Fungal Polyketide Biosynthesis2019
- Author(s)
  Kishimoto Shinji、Tsunematsu Yuta、Matsushita Takuma、Hara Kodai、Hashimoto Hiroshi、Tang Yi、Watanabe Kenji
- Journal Title
  
  Biochemistry,
  
  Volume: 58 Pages: 3933-3937
- DOI
  10.1021/acs.biochem.9b00702
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07314, KAKENHI-PROJECT-19K15757, KAKENHI-PROJECT-19KK0150, KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-16H05840
[Journal Article] Polyketide synthase-nonribosomal peptide synthetase hybrid enzymes of fungi2018
- Author(s)
  Kishimoto, S., Hirayama, Y., Watanabe, K.
- Journal Title
  
  The Mycota XV: Physiology and Genetics
  
  Volume: 368 Pages: 1-1
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06449
[Journal Article] Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids2018
- Author(s)
  Li Li、Tang Man-Cheng、Tang Shoubin、Gao Shushan、Soliman Sameh、Hang Leibniz、Xu Wei、Ye Tao、Watanabe Kenji、Tang Yi
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 140 Pages: 2067-2071
- DOI
  10.1021/jacs.8b00056
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Journal Article] Enzymatic Amide Tailoring Promotes Retro-Aldol Amino Acid Conversion To Form the Antifungal Agent Aspirochlorine2018
- Author(s)
  Tsunematsu Yuta、Maeda Naoya、Yokoyama Mamoru、Chankhamjon Pranatchareeya、Watanabe Kenji、Scherlach Kirstin、Hertweck Christian
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 57 Pages: 14051-14054
- DOI
  10.1002/anie.201806740
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-17K15265
[Journal Article] Enzymatic one-step ring contraction for quinolone biosynthesis2018
- Author(s)
  Kishimoto Shinji、Hara Kodai、Hashimoto Hiroshi、Hirayama Yuichiro、Champagne Pier Alexandre、Houk Kendall N.、Tang Yi、Watanabe Kenji
- Journal Title
  
  Nature Commun
  
  Volume: 9 Pages: 1-1
- DOI
  10.1038/s41467-018-05221-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07314, KAKENHI-PLANNED-16H06449, KAKENHI-PUBLICLY-17H06014, KAKENHI-PROJECT-16H04755, KAKENHI-PROJECT-16H05113, KAKENHI-PROJECT-16H05840
[Journal Article] Integration of chemical, genetic and bioinformatic approaches delineates fungal polyketide-peptide hybrid biosynthesis.2017
- Author(s)
  Yokoyama, M., Hirayama, Y., Yamamoto, T., Kishimoto, S., Tsunematsu, Y., Watanabe, K.
- Journal Title
  
  Org. Lett.
  
  Volume: 印刷中
- DOI
  10.1021/acs.orglett.7b00559
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-16H06449
[Journal Article] Oxidative Cyclization in Natural Product Biosynthesis2017
- Author(s)
  Tang Man-Cheng、Zou Yi、Watanabe Kenji、Walsh Christopher T.、Tang Yi
- Journal Title
  
  Chemical Reviews
  
  Volume: 117 Pages: 5226-5333
- DOI
  10.1021/acs.chemrev.6b00478
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Journal Article] Collaborative biosynthesis of maleimide- and succinimide- containing natural products by fungal polyketide megasynthases.2017
- Author(s)
  Sato, M., Dander, J. E., Sato, C., Hung, Y.-S., Gao, S.-S., Tang, M.-C., Hang, L., Winter, J. M., Garg, N. K.*, Watanabe, K.*, Tang, Y.*
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 印刷中
- DOI
  10.1021/jacs.7b02432
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KT0068
[Journal Article] Elucidation of Biosynthetic Pathways of Natural Products2017
- Author(s)
  Kishimoto, S., Tsunematsu, Y., Sato, M., Watanabe, K.
- Journal Title
  
  The Chemical Record
  
  Volume: 印刷中 Pages: 1095-1108
- DOI
  10.1002/tcr.201700015
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KT0068, KAKENHI-PROJECT-17K15265, KAKENHI-PLANNED-16H06449
[Journal Article] SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis2017
- Author(s)
  1.Ohashi, M., Liu, F., Hai, Y., Chen, M., Tang, M.-C., Yang, Z., Sato, M., Watanabe, K., Houk, K. N., Tang, Y.
- Journal Title
  
  Nature
  
  Volume: 549 Pages: 502-506
- DOI
  10.1038/nature23882
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Journal Article] Integration of Chemical, Genetic, and Bioinformatic Approaches Delineates Fungal Polyketide-Peptide Hybrid Biosynthesis2017
- Author(s)
  Yokoyama M, Hirayama Y, Yamamoto T, Kishimoto S, Tsunematsu Y, Watanabe K
- Journal Title
  
  Org Lett
  
  Volume: 19 Pages: 2002-2005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Journal Article] Biochemical characterization of an eukaryotic decalin-forming Diels-Alderase.2016
- Author(s)
  Li, L., Yu, P., Tang, M. C., Zou, Y., Gao, S.-S., Hung, Y.-S., Zhao, M., Watanabe, K., Houk, K., Tang, Y.
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 138 Pages: 15837-15840
- DOI
  10.1021/jacs.6b10452
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-15KT0068
[Journal Article] OxidativetranstocisIsomerization of Olefins in Polyketide Biosynthesis2016
- Author(s)
  Tsuyoshi Yamamoto, Yuta Tsunematsu, Kodai Hara, Tomohiro Suzuki, Shinji Kishimoto, Hirokazu Kawaguchi, Hiroshi Noguchi, Hiroshi Hashimoto, Yi Tang, Kinya Hotta, & Kenji Watanabe
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 印刷中 Pages: 6207-6210
- DOI
  10.1002/anie.201600940
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25291017, KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-16H05840, KAKENHI-PROJECT-15K18491, KAKENHI-PROJECT-16K00397, KAKENHI-PROJECT-16H04755
[Journal Article] Oxidative trans-to-cis isomerization of olefin in polyketide biosynthesis.2016
- Author(s)
  Yamamoto, T., Tsunematsu, Y., Hara, K., Suzuki, T., Kishimoto, S., Kawagishi, H., Noguchi, H., Hashimoto, H., Tang, Y., Hotta, K., Watanabe, K.
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 55
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KT0068
[Journal Article] Regioselective dichlorination of a non-activated aliphatic carbon and phenol bismethylation by a multifunctional fungal flavoenzyme.2016
- Author(s)
  Chankhamjon, P., Tsunematsu, Y., Ishida-Ito, M., Sasa, Y., Meyer, F., Boettger-Schmidt, D., Urbansky, B., Menzel, K. D., Scherlach, K., Watanabe, K., Hertweck, C.
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 55 Pages: 11955-11959
- DOI
  10.1002/anie.201604516
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Journal Article] Activation of transient receptor potential ankyrin 1 by quercetin and its analogs2016
- Author(s)
  Toshiyuki Nakamura, Noriyuki Miyoshi, Takeshi Ishii, Miyu Nishikawa, Shinichi Ikushiro, Tatsuo Watanabe
- Journal Title
  
  Biosci Biotechnol Biochem.
  
  Volume: 80 Pages: 949-54
- DOI
  10.1080/09168451.2015.1132148
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K16212, KAKENHI-PROJECT-24300252, KAKENHI-PROJECT-26292072, KAKENHI-PROJECT-16H03041, KAKENHI-PROJECT-16K12726
[Journal Article] Combinatorial generation of chemical diversity by redox enzymes in chaetoviridin biosynthesis.2016
- Author(s)
  Sato M, Winter JM, Kishimoto S, Noguchi H, Tang Yi, Watanabe K
- Journal Title
  
  Org. Lett.
  
  Volume: 18 Pages: 1446-1449
- DOI
  10.1021/acs.orglett.6b00380
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05840, KAKENHI-PROJECT-15KT0068
[Journal Article] Elucidation of Pyranonigrin Biosynthetic Pathway Reveals a Mode of Tetramic Acid, Fused γ-Pyrone, and exo-Methylene Formation.2015
- Author(s)
  Yamamoto, T., Tsunematsu, Y., Noguchi, H., Hotta, K., Watanabe, K.
- Journal Title
  
  Org. Lett.
  
  Volume: 17 Pages: 4992-4995
- DOI
  10.1021/acs.orglett.5b02435
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KT0068
[Journal Article] Elucidation of shanorellin biosynthetic pathway and functional analysis of associated enzymes.2015
- Author(s)
  Sato, M., Yamada, H., Hotta, K., Watanabe, K.
- Journal Title
  
  MedChemComm
  
  Volume: 6 Pages: 425-430
- DOI
  10.1039/c4md00352g
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670048
[Journal Article] Tandem prenyltransferases catalyze isoprenoid elongation and complexity generation in biosynthesis of quinolone alkaloids.2015
- Author(s)
  Zou, Y., Zhan, Z., Li, D., Tang, M., Watanabe, K., Tang, Y.
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 137 Pages: 4980-4983
- DOI
  10.1021/jacs.5b03022
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26560450
[Journal Article] Biochemical and structural basis for controlling chemical modularity in fungal polyketide biosynthesis.2015
- Author(s)
  Winter, J. M., Cascio, D., Dietrich, D., Sato, M., Watanabe, K., Sawaya, M., Vederas, J. C., Tang, Y.
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 137 Pages: 9885-9893
- DOI
  10.1021/jacs.5b04520
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26560450
[Journal Article] Combinatorial generation of complexity by redox enzymes in the chaetoglobosin a biosynthesis2013
- Author(s)
  K. Ishiuchi, T. Nakazawa, F. Yagishita, T. Mino, H. Noguchi, K. Hotta, K. Watanabe
- Journal Title
  
  J. Am. Chem. Soc
  
  Volume: 135 Pages: 7371-7377
- Data Source
  KAKENHI-PROJECT-22241054
[Journal Article] Targeted disruption of transcriptional regulators in Chaetomium globosum activates biosynthetic pathways and reveals transcriptional regulator-like behavior of aureonitol,2013
- Author(s)
  Nakazawa T, et al.
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 135 Pages: 13446-13455
- DOI
  10.1021/ja405128k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23406031, KAKENHI-PROJECT-25242067
[Journal Article] Combinatorial Generation of Complexity by Redox Enzymes in the Chaetoglobosin A Biosynthesis.2013
- Author(s)
  K. Ishiuchi, T. Nakazawa, F. Yagishita, T. Mino, H. Noguchi, K.a Hotta, K. Watanabe
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 135 Pages: 7371-7377
- DOI
  10.1021/ja402828w
- URL
  http://dx.doi.org/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241054, KAKENHI-PROJECT-23406031, KAKENHI-PROJECT-23880025, KAKENHI-PROJECT-25242067
[Journal Article] Distinct mechanisms for spiro-carbon formation reveal biosynthetic pathway crosstalk.2013
- Author(s)
  石川格靖, 他8名
- Journal Title
  
  Nat Chem Biol
  
  Volume: 9 Pages: 818-25
- DOI
  10.1038/nchembio.1366
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J10688, KAKENHI-PROJECT-23310140, KAKENHI-PROJECT-23406031, KAKENHI-PUBLICLY-25108717, KAKENHI-PROJECT-25242067, KAKENHI-PROJECT-25640115
[Journal Article] Establishing a new methodology for genome mining and biosynthesis of polyketides and peptides through yeast molecular genetics2012
- Author(s)
  K. Ishiuchi, T. Nakazawa, T. Ookuma, S. Sugimoto, M. Sato, Y. Tsunematsu, N. Ishikawa, H. Noguchi, K. Hotta, H. Moriya, K. Watanabe
- Journal Title
  
  ChemBioChem
  
  Volume: 13(6) Pages: 846-854
- Data Source
  KAKENHI-PROJECT-22241054
[Journal Article] Overexpressing transcriptional regulator in Aspergillus oryzae activates a silent biosynthetic pathway to produce novel polyketide2012
- Author(s)
  T. Nakazawa, K. Ishiuchi, A. Praseuth, H. Noguchi, K. Hotta, K. Watanabe
- Journal Title
  
  ChemBioChem
  
  Volume: 13(6) Pages: 855-861
- Data Source
  KAKENHI-PROJECT-22241054
[Journal Article] Establishing a new methodology for genome mining and biosynthesis of polyketides and peptides through yeast molecular genetics2012
- Author(s)
  Ishiuchi, K., Nakazawa, T., Ookuma, T., Sugimoto, T., Sato, M., Tsunematsu, Y., Ishikawa, N., Noguchi, H., Hotta, K., Moriya, H., Watanabe, K.
- Journal Title
  
  ChemBioChem
  
  Volume: 13 Pages: 846-854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241054
[Journal Article] Overexpressing transcriptional regulator in Aspergillus oryzae activates a silent biosynthetic pathway to produce novel polyketide2012
- Author(s)
  Nakazawa, T., Ishiuchi, K., Praseuth, A., Noguchi, H., Hotta, K., Moriya, H., Watanabe, K.
- Journal Title
  
  ChemBioChem
  
  Volume: 13 Pages: 855-861
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241054
[Journal Article] Overexpressing transcriptional regulator in Chaetomium globosum activates a silent biosynthetic pathway: evaluation of shanorellin biosynthesis2012
- Author(s)
  Y. Tsunematsu, S. Ichinoseki, T. Nakazawa, N. Ishikawa, H. Noguchi, K. Hotta, K. Watanabe
- Journal Title
  
  J. of Antibiotics
  
  Volume: 65(7) Pages: 377-380
- NAID
  10030955543
- Data Source
  KAKENHI-PROJECT-22241054
[Journal Article] Overexpressing transcriptional regulator in Aspergillus oryzae activates a silent biosynthetic pathway to produce novel polyketide.2012
- Author(s)
  T. Nakazawa, K. Ishiuchi, A. Praseuth, H. Noguchi, K. Hotta, K. Watanabe
- Journal Title
  
  Chembiochem
  
  Volume: 13(6) Pages: 846-854
- DOI
  10.1002/cbic.201200107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241054, KAKENHI-PROJECT-23406031, KAKENHI-PROJECT-23880025
[Journal Article] Establishing a new methodology for genome mining and biosynthesis of polyketides and peptides through yeast molecular genetics.2012
- Author(s)
  石内勘一郎、佐藤道大, 他9名
- Journal Title
  
  ChemBioChem
  
  Volume: 13 Pages: 846-54
- DOI
  10.1002/cbic.201100798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J01668, KAKENHI-PROJECT-22241054, KAKENHI-PROJECT-23310140, KAKENHI-PROJECT-23406031, KAKENHI-PROJECT-23880025
[Journal Article] Development of EST-SSR markers of Ipomoea nil2012
- Author(s)
 T. Ly, H. Fukuoka, A. Otaka, A. Hoshino, S. Iida, E. Nitasaka, N. Watanabe and T. Kuboyama
- Journal Title
 
 Breed. Sci.
 
 Volume: 62 Issue: 1 Pages: 99-104
- DOI
 10.1270/jsbbs.62.99
- NAID
 130004146342
- ISSN
 1344-7610, 1347-3735
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-22370001, KAKENHI-PROJECT-22770047, KAKENHI-PROJECT-24501059
[Journal Article] A comprehensive overview on genomically directed assembly of aromatic polyketides and macrolide lactones using fungal megasynthases2011
- Author(s)
  Saruwatari, T., Praseuth, A.P., Sato, M., Torikai, K., Noguchi, H., Watanabe, K.
- Journal Title
  
  J.Antibiot.
  
  Volume: 64 Pages: 9-17
- NAID
  10030637198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241054
[Journal Article] A comprehensive overview on genomically directed assembly of aromatic polyketides and macrolide lactones using fungal megasynthases2011
- Author(s)
  T. Saruwatari, A. P Praseuth, M. Sato, K. Torikai, H. Noguchi, K. Watanabe
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 64 Pages: 9-17
- NAID
  10030637198
- Data Source
  KAKENHI-PROJECT-22241054
[Journal Article] Practical Synthesis of dopa derivative for biosynthetic production of potent antitumor natural products, Saframycins and Ecteinascidin 7432011
- Author(s)
  K. Torikai, T. Saruwatari, T. Kitano, T. Sano, A. Nakane, H. Noguchi, K. Watanabe
- Journal Title
  
  Letters In Organic Chemistry
  
  Volume: 8-10 Pages: 686-689
- NAID
  120005133055
- Data Source
  KAKENHI-PROJECT-22241054
[Journal Article] 生合成マシナリーを用いた抗腫瘍性物質生産の試み2011
- Author(s)
  渡辺賢二
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 69 Pages: 26-30
- NAID
  10027617152
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] A comprehensive overview on genomically directed assembly of aromatic polyketides and macrolide lactones using fungal megasynthases2011
- Author(s)
  T.Saruwatari, A.P Praseuth, M.Sato, K.Torikai, H.Noguchi, K.Watanabe
- Journal Title
  
  Journal of Antibiotics
  
  Volume: 64 Pages: 9-17
- NAID
  10030637198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241054
[Journal Article] Practical synthesis of DOPA derivative for biosynthetic production of potent antitumor natural products, saframycins and ecteinascidin 7432011
- Author(s)
  Torikai, K., Saruwatari, T., Kitano, T., Sano, T., Nakane, A., Noguchi, H., Watanabe, K.
- Journal Title
  
  Letters In Organic Chemistry
  
  Volume: 8 Pages: 686-689
- NAID
  120005133055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241054
[Journal Article] 生合成マシナリーを用いた抗腫瘍性物質生産の試み,バイオサイエンスとインダストリー2011
- Author(s)
  渡辺賢二, 大栗博毅, 及川英秋
- Journal Title
  
  バイオインダストリー協会 69
  
  Pages: 26-30
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms.2010
- Author(s)
  Koketsu, K., Oguri, H., Watanabe, K., Oikawa, H.
- Journal Title
  
  Nature Chemical Biology 6
  
  Pages: 408-410
- NAID
  120002646838
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Intriguing substrate tolerance of epoxide hydrolase Lsd19 involved in biosynthesis of the ionophore antibiotic lasalocid A.2010
- Author(s)
  Matsuura, Y., Shichijo, Y., Minami, A., Migita, A., Oguri, H., Watanabe, M., Tokiwano, T., Watanabe, K., Oikawa, H.
- Journal Title
  
  Org.Lett. 12
  
  Pages: 2226-2229
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Plasmid construction using recombination activity in the fission yeast Schizosaccharomyces pombe.2010
- Author(s)
  Chino, A., Watanabe, K., Moriya, M.
- Journal Title
  
  PLoS One 5
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Identification of a gene cluster of polyether antibiotic lasalocid from Streptomyces lasaliensis.2009
- Author(s)
  Migita, A., Watanabe, M., Hirose, Y., Watanabe, K., Tokiwano, T., Kinashi, H., Oikawa, H.
- Journal Title
  
  Biosci.Biotechnol.Biochem. 73
  
  Pages: 169-176
- NAID
  10027536367
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Enzymatic synthesis of molecular skeletons of complex antitumor antibiotics with non-ribosomal peptide synthetases.2009
- Author(s)
  Watanabe, K., Oguri, H, Oikawa, H.
- Journal Title
  
  Journal of Synthetic Organic Chemistry,Japan 67
  
  Pages: 1152-1160
- NAID
  10026866717
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product.2009
- Author(s)
  Watanabe, K., Hotta, K., Nakaya, M., Praseuth, A.P., Wang, C.C.C., Inada, D., Takahashi, K., Fukushi, F., Oguri, H., Oikawa, H.
- Journal Title
  
  J.Am.Chem.Soc. 131
  
  Pages: 9347-9353
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural product2009
- Author(s)
  Watanabe, K., et al.
- Journal Title
  
  J Am Chem Soc 131
  
  Pages: 9347-9353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Genetic indoctrination of Escherichia coli for innovative drug discovery by way of heterologous expression of the echinomycin biosynthetic pathway.2009
- Author(s)
  Watanabe, K., Oguri, H., Oikawa, H.
- Journal Title
  
  Current Opinion in Chemical Biology 13
  
  Pages: 189-196
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Sequence and analysis of the SF2575 gene cluster and characterization of key tailoring enzyme.2009
- Author(s)
  Pickens, L.B., Wang, P., Zhou, H., Kim, W., Watanabe, K., Gomi, S., Tang, Y.
- Journal Title
  
  J.Am.Chem.Soc. 131
  
  Pages: 17677-17689
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Rationally engineered total biosynthesis of a synthetic analogue of natural quinomycin depsipeptide in Escherichia coli2009
- Author(s)
  Watanabe, K., et al.
- Journal Title
  
  ChembioChem 10
  
  Pages: 1965-1968
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Chromatin-level regulation of biosynthetic gene clusters.2009
- Author(s)
  Bok, J.W., Chiang, Y. M., Szewczyk, E., Reyes-Domingez, Y., Davidson, A.D., Sanchez, J.F., Lo, H.C., Watanabe, K., Strauss, J., Oakley, B.R., Wang, C.C.C., Keller, N.P.
- Journal Title
  
  Nature Chemical Biology 5
  
  Pages: 462-464
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Rationally Engineered Total Biosynthesis of a Synthetic Analog of a Natural Quinomycin Depsipeptide in Escherichia coli.2009
- Author(s)
  Watanabe, K., Hotta, K., Praseuth, A.P., Searcey, M., Wang, C.C.C., Oguri, H., Oikawa, H.
- Journal Title
  
  ChemBioChem 10
  
  Pages: 1965-1968
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] Involvement of common intermediate L-3-hydroxyknyurenine in the chromophore biosynthesis of quinomycin family antibiotics.
- Author(s)
  Hirose, Y., Watanabe, K., Minami, A., Nakamura, T., Oguri, H., Oikawa, H.
- Journal Title
  
  J.Antibiot. in press.
- Data Source
  KAKENHI-PROJECT-21780106
[Journal Article] A comprehensive overview on genomically directed assembly of aromatic polyketides and macrolide lactones using fungal megasynthases.
- Author(s)
  Saruwatari, T., Praseuth, A. P., Sato, M., Torikai, K., Noguchi, H., Watanabe, K.
- Journal Title
  
  J.Antibiot. in press.
- NAID
  10030637198
- Data Source
  KAKENHI-PROJECT-21780106
[Patent] コリバクチン産生菌検出用プライマーセット及び検出用キット2019
- Inventor(s)
  渡辺賢二
- Industrial Property Rights Holder
  渡辺賢二
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-027695
- Filing Date
  2019
- Data Source
  KAKENHI-PLANNED-16H06449
[Patent] コリバクチンおよびコリバクチン産生菌の検出方法および検出プローブ2018
- Inventor(s)
  渡辺賢二
- Industrial Property Rights Holder
  渡辺賢二
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PLANNED-16H06449
[Patent] カビ類ポリケチド合成遺伝子の酵母での異種発現2010
- Inventor(s)
  渡辺賢二, 守屋央朗
- Industrial Property Rights Holder
  静岡県立大学, 岡山大学
- Industrial Property Number
  2010-181279
- Filing Date
  2010-08-13
- Data Source
  KAKENHI-PROJECT-21780106
[Patent] カビ類ポリケチド合成遺伝子の酵母での異種発現2010
- Inventor(s)
  渡辺賢二、守屋央朗
- Industrial Property Rights Holder
  静岡県立大学、岡山大学
- Filing Date
  2010-08-13
- Data Source
  KAKENHI-PROJECT-21780106
[Presentation] 大腸がんリスク因子コリバクチン産生菌の増殖抑制を目的としたパイロット介入試験2019
- Author(s)
  渡辺賢二
- Organizer
  日本がん予防学会学
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02898
[Presentation] Crystallographic characterization of a [4+2]-cyclase binding site and mutational alteration of stereoselectivity2018
- Author(s)
  Kenji Watanabe
- Organizer
  The 2nd International Symposium on Organic Reaction Mechanism
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] Simple Screening for High-Colibactin Producers from Clinical Samples Using Activity- Based Fluorescent Probe2018
- Author(s)
  Kenji Watanabe
- Organizer
  U.S.-Japan Cooperative Medical Sciences Program (USJCMSP)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] Assay for proinflammatory activity of structurally modified lipid A.2018
- Author(s)
  Sayaka Ohashi, Tsutomu Hashidume, Noriko Ishiduka, Hisayoshi Hayashi, Yasuaki Kawarasaki, Kenji Watanabe, Yuko Yoshikawa, Noriyuki Miyoshi
- Organizer
  第23回静岡健康・長寿学術フォーラム
- Data Source
  KAKENHI-PROJECT-16H03041
[Presentation] Lipid A biosynthesis in E. coli cultured in metal-depletion2018
- Author(s)
  Sayaka Ohashi, Tsutomu Hashidume, Noriko Ishiduka, Hisayoshi Hayashi, Yasuaki Kawarasaki, Kenji Watanabe, Yuko Yoshikawa, Noriyuki Miyoshi
- Organizer
  Shizuoka ICPF 2018
- Data Source
  KAKENHI-PROJECT-16H03041
[Presentation] Simple Screening for High-Colibactin Producers from Clinical Samples Using Activity- Based Fluorescent Probe2018
- Author(s)
  Kenji Watanabe
- Organizer
  30th International Symposium on the Chemistry of Natural Products
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] ENZYMATIC ONE-STEP RING CONTRACTION FOR QUINOLONE BIOSYNTHESIS2018
- Author(s)
  Kenji Watanabe
- Organizer
  2nd China-Japan Joint Symposium on Natural Product Biosynthesis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] Simple Screening for High-Colibactin Producers from Clinical Samples Using Activity- Based Fluorescent Probe2018
- Author(s)
  Kenji Watanabe
- Organizer
  6th Biennial International Conference on New Developments in Drug Discovery from Natural Products and Traditional Medicines
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] Disfavored exo-adduct formation by a modified octalin-forming Diels-Alderase2017
- Author(s)
  渡辺賢二
- Organizer
  China/Japan Symposium on Natural Product Biosynthesis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] 実用的物質生産系構築にむけたゲノム情報に基づく新規生合成システムのリデザイ2017
- Author(s)
  渡辺賢二
- Organizer
  生物合成系の再設計による複雑骨格機能分子の革新的創成化学（新学術領域）第一回公開シンポジウム
- Place of Presentation
  東京大学, 東京
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] Genetic indoctrination of Escherichia coli for finding genotoxins “colibactin” facilitating inflammation-induced colorectal cancer2017
- Author(s)
  Kenji Watanabe
- Organizer
  US-Japan Cooperative Medical Sciences Program, 19th International Conference on Emerging Infectious Diseases in the Pacific Rim
- Place of Presentation
  Seoul, South Korea
- Year and Date
  2017-02-07
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] Disfavored exo-adduct generation by a modified octalin-forming Diels-Alderase2017
- Author(s)
  渡辺賢二
- Organizer
  Society for Industrial Microbiology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] Genetic indoctrination of Escherichia coli for finding genotoxins colibactin facilitating inflammation-induced colorectal cancer2017
- Author(s)
  渡辺賢二
- Organizer
  US-Japan Cooperative Medical Sciences Program Cancer Panel Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] 立体選択的な環化反応を触媒する酵素CghAの反応機構解析2017
- Author(s)
  横山葵, 岸本真治, 佐藤道大, 原幸大, 恒松雄太, 橋本博, 渡辺賢二
- Organizer
  日本薬学会第137年会
- Place of Presentation
  東北大学、仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15KT0068
[Presentation] 立体選択的な環化反応を触媒する酵素CghAの反応機構解析2017
- Author(s)
  横山葵, 岸本真治, 佐藤道大, 原幸大, 恒松雄太, 橋本博, ※渡辺賢二
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学、京都
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15KT0068
[Presentation] Pseurotin biosynthesis in fungus2017
- Author(s)
  渡辺賢二
- Organizer
  9th US-Japan Seminar: The international Conference of Natural Product Biosynthesis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] Genetic indoctrination of Escherichia coli for finding genotoxins “colibactin” facilitating inflammation-induced colorectal cancer2017
- Author(s)
  Kenji Watanabe
- Organizer
  U.S.-Japan Cooperative Medical Sciences Program (USJCMSP) Cancer Panel Meeting
- Place of Presentation
  Seoul, Korea
- Year and Date
  2017-02-07
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26560450
[Presentation] Novel Genotoxins “Colibactin” Produced by E.coli and colon carcinogenesis (In Vitro, In Vivo Experiments)2017
- Author(s)
  渡辺賢二
- Organizer
  The 12th international conference and 5th Asian congress on environmental mutagens with the 33rd annual meeting of KSOT/KEMS
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] 冬虫夏草Cordyceps militarisにおけるcordycepin生合成経路の研究2017
- Author(s)
  天内優子、崔宰熏、恒松雄太、渡辺賢二、道羅英夫、鈴木智大、河岸洋和
- Organizer
  日本農芸化学会
- Place of Presentation
  京都女子大学、京都
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-26670048
[Presentation] Oxidative trans-to-cis isomerization of olefin in polyketide biosynthesis2016
- Author(s)
  Kenji Watanabe
- Organizer
  The 13th International Symposium on the Genetics of Industrial Microorganisms
- Place of Presentation
  Wuhan, People’s Republic of China
- Year and Date
  2016-10-16
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06449
[Presentation] Development of catalysts from natural product biosynthesis as reagents for enzymatic syntheses of potential drugs as well as natural products2016
- Author(s)
  Kenji Watanabe
- Organizer
  Biosystems Design Symposium 2.0
- Place of Presentation
  Singapore
- Year and Date
  2016-03-21
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KT0068
[Presentation] Aspoquinolone biosynthesis: Non-heme dioxygenase catalyzes atypical oxidations of 6,7-bicycle to form 6,6-quinolone core of viridicatin-type fungal alkaloid2015
- Author(s)
  Kenji Watanabe
- Organizer
  Pacifichem 2015
- Place of Presentation
  Honolulu, Hawaii
- Year and Date
  2015-12-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KT0068
[Presentation] Elucidation of pyranonigrin biosynthetic pathway reveals mechanism of fused γ-pyrone, exo-methylene and spiral cyclobutane formation2015
- Author(s)
  Kenji Watanabe
- Organizer
  Pacifichem 2015
- Place of Presentation
  Honolulu, Hawaii
- Year and Date
  2015-12-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KT0068
[Presentation] 大腸がん原因物質コリバクチンの生合成機構の解明2015
- Author(s)
  佐々侑寿香、石川格靖、小山ふみ、福冨愛実、野口博司、渡辺賢二
- Organizer
  日本薬学会第135年会（神戸）
- Place of Presentation
  兵庫医療大学
- Year and Date
  2015-03-26
- Data Source
  KAKENHI-PROJECT-26560450
[Presentation] 大腸がん原因物質コリバクチンの生合成機構の解明2015
- Author(s)
  佐々侑寿香、石川格靖、小山ふみ、福冨愛実、野口博司、渡辺賢二
- Organizer
  日本農芸化学会2015年度大会（岡山）
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-26560450
[Presentation] Biosynthesis of a Cancer–Inducing Compound in Escherichia coli2015
- Author(s)
  Masao Oohashi, Yuzuka Sasa, Noriyasu Ishikawa, Hiroshi Noguchi and Kenji Watanabe
- Organizer
  Pacifichem 2015
- Place of Presentation
  Honolulu, Hawaii, USA.
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26560450
[Presentation] 大腸がん原因物質colibactinの化学構造解明2015
- Author(s)
  大橋雅生、渡辺賢二
- Organizer
  天然物談話会
- Place of Presentation
  宮城県岩沼市
- Year and Date
  2015-07-01
- Data Source
  KAKENHI-PROJECT-26560450
[Presentation] Natural products from fungi2013
- Author(s)
  Kenji Watanabe
- Organizer
  3rd International Conference on Natural product Biosynthesis
- Place of Presentation
  University of California Los Angeles, University of Southern California (USA)
- Invited
- Data Source
  KAKENHI-PROJECT-25242067
[Presentation] Functional reconstitution of the saframycin biosynthetic enzymes2012
- Author(s)
  K. Watanabe
- Organizer
  RCIS International Conference
- Place of Presentation
  Okayama
- Data Source
  KAKENHI-PROJECT-22241054
[Presentation] Biosynthesis of natural products through a fungal molecular genetics2012
- Author(s)
  T. Nakazawa, T. Ookuma, S. Sugimoto, S. Ichinoseki, Y. Gotanda, N. Ishikawa, Y. Tsunematsu, K. Ishiuchi, H. Noguchi, K. Watanabe
- Organizer
  Philipps-Universitat Marburg
- Place of Presentation
  Germany
- Data Source
  KAKENHI-PROJECT-22241054
[Presentation] Biologically active molecules from fungi2012
- Author(s)
  Kenji Watanabe
- Organizer
  第8回天然物生合成日米セミナー
- Place of Presentation
  淡路
- Data Source
  KAKENHI-PROJECT-22241054
[Presentation] Biosynthesis of Natural Products Through a Fungal Molecular Genetics2012
- Author(s)
  T. Nakazawa, T. Ookuma, S. Sugimoto, S. Ichinoseki, Y. Gotanda, N. Ishikawa, Y. Tsunematsu, K. Ishiuchi, H. Noguchi, K. Watanabe
- Organizer
  11th European Conference on Fungal Genetics.
- Place of Presentation
  Philipps-Universität Marburg (Germany)
- Data Source
  KAKENHI-PROJECT-22241054
[Presentation] Yeast, a more manageable non-ribosomal peptide mill for Spirotryprostatin B assembly2011
- Author(s)
  K. Watanabe
- Organizer
  11th European Conference on Fungal Genetics. Society for Industrial Microbiology, Annual meeting and exhibition 2011
- Place of Presentation
  Sheraton New Orleans, New Orleans (LA)
- Year and Date
  2011-07-24
- Data Source
  KAKENHI-PROJECT-22241054
[Presentation] T. Nakazawa, K. Ishiuchi, K. Hotta, H.Noguchi, H. Moriya, K. Watanabe2011
- Author(s)
  T. Nakazawa, K. Ishiuchi, K. Hotta, H.Noguchi, H. Moriya, K. Watanabe
- Organizer
  8th AFMC International Medicinal Chemistry Symposium "Frontier of Medicinal Science"
- Place of Presentation
  KEIO PLAZA HOTEL TOKYO(東京)
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-22241054
[Presentation] Yeast, a more manageable non-ribosomal peptide mill for Spirotryprostatin B assembly.2011
- Author(s)
  K. Watanabe
- Organizer
  International Union of Microbiological Societies 2011 Congress, Sapporo Convention Center
- Place of Presentation
  札幌
- Year and Date
  2011-09-06
- Data Source
  KAKENHI-PROJECT-22241054
[Presentation] 合理的設計に基づく改変生合成遺伝子群を用いた非天然型生物活性環状デプシペプチドの合成2010
- Author(s)
  渡辺賢二
- Organizer
  生体触媒化学シンポジウム
- Place of Presentation
  静岡市
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21780106
[Presentation] 生合成遺伝子の大腸菌発現による抗腫瘍性生理活性物質サフラマシンの効率的合成2010
- Author(s)
  渡辺賢二
- Organizer
  アステラス病態研究会
- Place of Presentation
  経団連会館,東京
- Year and Date
  2010-10-16
- Data Source
  KAKENHI-PROJECT-21780106
[Presentation] 天然物合成を指向した生合成遺伝子の異種発現によるシンセティックバイオロジーの確立2010
- Author(s)
  渡辺賢二
- Organizer
  バイオインダストリー協会
- Place of Presentation
  パシフィコ横浜,横浜
- Year and Date
  2010-09-29
- Data Source
  KAKENHI-PROJECT-21780106
[Presentation] Rational Design of Natural Products through Controlled Biosynthesis2009
- Author(s)
  Kenji Watanabe
- Organizer
  5th Japan-Korea Young Scientists Meeting on Bioorganic and Natural Products Chemistry
- Place of Presentation
  Shizuoka, JAPAN
- Data Source
  KAKENHI-PROJECT-21780106
[Presentation] Rational Design of Natural Products through Controlled BiosynthesisSociety for Industrial Microbiology2009
- Author(s)
  Kenji Watanabe
- Organizer
  Annual meeting and exhibition 2009
- Place of Presentation
  Westin Harbour Castle Hotel, Toronto, ON, Canada
- Data Source
  KAKENHI-PROJECT-21780106

1. NOGUCHI Hiroshi (60126141)

# of Collaborated Projects: 4 results

# of Collaborated Products: 22 results
2. UMEHARA KAORU (40185070)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. IIDA Shigeru (30012777)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. JOHZUKA Yasuyo (60517887)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 阿部郁朗 (40305496)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 菅裕明 (00361668)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 梅野太輔 (00400812)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 葛山智久 (30280952)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 南篤志 (40507191)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 濱野吉十 (50372834)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 江口正 (60201365)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 山崎真巳 (70222370)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 大利徹 (70264679)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. 脇本敏幸 (70363900)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. 池田治生 (90159632)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. KINOSHITA Tetsu (60342630)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. ISHIZAKI Kimitsune (00452293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KOBAYASHI Hirokazu (80170348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. MORITA HIROYUKI (20416663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. Miyoshi Noriyuki (70438191)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
21. 久城哲夫 (80373299)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 植木尚子 (50622023)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 佐藤道大 (10629695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
24. 恒松雄太 (30629697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
25. 岸本真治 (40814330)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. YOSHIKAWA Yuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
27. NAKAZAWA Takehito

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
28. ISHII Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 橋本博

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
30. 原幸大

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
31. 石川格靖

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
32. 守屋央朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
33. 仁田坂英二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 中村俊之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 生城真一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

WATANABE KENJI 渡辺 賢二

WATANABE Kenji 渡辺 賢二

渡辺 賢二 ワタナベ ケンジ

Research Projects

Research Products

Co-Researchers

Chemical characterization of colibactin and understanding a mechanism of an onset of colorectal cancer by colibactinPrincipal InvestigatorOngoing

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Cell therapy by using engineered biosynthesis of anticancer agent in tumor cellsPrincipal InvestigatorOngoing

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Integrating Computational and Experimental Approaches for New Paradigms in Molecule SynthesisPrincipal InvestigatorOngoing

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生合成リデザイン・研究総括班Ongoing

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Engineered biosynthesis of new natural products for innovative drug discoveryPrincipal InvestigatorOngoing

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Profiling analysis of intestinal endotoxins associated with chronic inflammation in lifestyle-related diseases

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生合成リデザイン・国際活動支援班Ongoing

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Diels-Alder反応を触媒する酵素が持つ遷移状態制御の解明Principal Investigator

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Characterization of genotoxins, colibactin, facilitating inflammation-induced colorectal cancerPrincipal Investigator

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Unprecedented enzyme-catalyzed generation of complexity in fumagillin-pseurotin biosynthesis

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Unification of biosynthetic pathways of a variety of plant polyketides

Principal Investigator

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生合成遺伝子の異種発現によるテトラヒドロイソキノリン類の合成Principal Investigator

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有用天然物の生合成遺伝子発現によるシンセティックバイオロジーの確立Principal Investigator

Principal Investigator

WATANABE KENJI 渡辺賢二

WATANABE Kenji 渡辺賢二

渡辺賢二ワタナベケンジ