SAITOH Tsuyoshi 斉藤毅

… Alternative Names

Researcher Number	80609933
Other IDs	https://orcid.org/0000-0001-6105-6292
Affiliation (Current)	2021: 筑波大学, 国際統合睡眠医科学研究機構, 助教
Affiliation (based on the past Project Information) *help	2021: 筑波大学, 学内共同利用施設等, 助教 2015 – 2021: 筑波大学, 国際統合睡眠医科学研究機構, 助教 2013: 慶應義塾大学, 理工学部, 助教 2012: 筑波大学, 学内共同利用施設等, 助教 2011: 慶應義塾大学, 理工学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 37030:Chemical biology-related / Transformative Research Areas, Section (II) / Chemical biology Except Principal Investigator Chemical biology / Drug development chemistry / Basic / Social brain science / General medical chemistry / Basic Section 59040:Nutrition science and health science-related / Basic Section 48040:Medical biochemistry-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Keywords	Principal Investigator オレキシン / 睡眠覚醒 / 作動薬 / ケージド化合物 / 光ケージド化合物 / 睡眠 / 覚醒 / スイッチング化合物 / 光ケージド薬物 / 光反応 … More Except Principal Investigator ナルコレプシー / GPCR / オレキシン / 作動薬 / オレキシン受容体 / 睡眠 / シグナル伝達 / X線結晶構造解析 / 薬剤開発 / 創薬 / 分子デザイン / バイオイメージング / 腹腔内転移 / 浸潤 / 遊走 / NF-kappa B / DHMEQ / DTCM-glutarimide / migracin / Exo-ene EQ / pyrapaxilline / 卵巣がん / 転移 / アノイキス / メラノーマ / 卵巣癌 / NF-κB / 探索プローブ / 標的タンパク質 / 光プローブ / オピオイド / モルヒナン / 拮抗薬 / 創薬化学 / 有機合成化学 / ナルフラフィン / 覚醒 / Sleep / Motivation / Nucleus Accumbens / Nucleus accumbens / ヒト膜受容体 / 抗体 / 機能性抗体 / 膜タンパク質 / オレキシン受容体作動薬 / バイアスドリガンド / クライオ電子顕微鏡 / クライオ電子顕微鏡単粒子解析 / SBDD / バイアスリガンド / アゴニスト / オレキシン1受容体 / 薬理評価 / 機能解明 Less

Multi-scale platform for untangling physiological complexityArea Organizer
- Area Organizer
  
  斉藤毅
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
マルチスケールな生理作用の因数分解基盤構築の支援Principal Investigator
- Principal Investigator
  
  斉藤毅
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  University of Tsukuba
モルヒナン骨格を基盤とした三次元的フォーカスドライブラリーの構築Principal Investigator
- Principal Investigator
  
  斉藤毅
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  University of Tsukuba
Development of novel selective orexin 1 receptor agonists and elucidation of the function of orexin receptors
- Principal Investigator
  
  長瀬博
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  University of Tsukuba
Development of novel PET probes targeting orexin 1 receptorPrincipal Investigator
- Principal Investigator
  
  斉藤毅
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  University of Tsukuba
Structural analysis of G protein/Arrestin-GPCR complex for development of biased ligands
- Principal Investigator
  
  寿野良二
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kansai Medical University
オレキシン２型受容体作動薬による代謝リズム調節機構の解明
- Principal Investigator
  
  福住昌司
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  University of Tsukuba
Development of novel photochemical tools to regulate wakefulnessPrincipal Investigator
- Principal Investigator
  
  Tsuyoshi Saitoh
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  University of Tsukuba
The role of the nucleus accumbens in regulating slow-wave sleep by motivated behavior
- Principal Investigator
  
  ラザルスミハエル
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic / Social brain science
- Research Institution
  University of Tsukuba
Development of novel orexin ligand and its pharmacological activity
- Principal Investigator
  
  Nagase Hiroshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  University of Tsukuba
Development of novel molecular tool for controlling sleep/wake cycle and feeding behaviorPrincipal Investigator
- Principal Investigator
  
  SAITOH Tsuyoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical biology
- Research Institution
  University of Tsukuba
Differential analysis of the crystal structures of active / inactive orexin receptor contributing to rational development of sleep control drug
- Principal Investigator
  
  Suno Ryoji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
Bio-imaging of peritoneal metastasis and molecular design of inhibitors
- Principal Investigator
  
  UMEZAWA Kazuo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical biology
- Research Institution
  Aichi Medical University
  Keio University

All 2020 2019 2018 2017 2016 2015 2012 2011

All Journal Article Presentation Patent

[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group.2020
- Author(s)
  Saitoh T, Seki K, Nakajima R, Yamamoto N, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 29 Pages: 126893-126893
- DOI
  10.1016/j.bmcl.2019.126893
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11014, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-18K14352
[Journal Article] Enhancing endogenous adenosine A2A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function2019
- Author(s)
  Korkutata M, Saitoh T, Cherasse Y, Ioka S, Duo F, Qin R, Murakoshi N, Fujii S, Zhou X, Sugiyama F, Chen JF, Kumagai H, Nagase H, Lazarus M
- Journal Title
  
  Neuropharmacology
  
  Volume: 144 Pages: 122-132
- DOI
  10.1016/j.neuropharm.2018.10.022
- NAID
  120006583051
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PUBLICLY-18H04966, KAKENHI-PROJECT-17H02215
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring.2019
- Author(s)
  Yamamoto Naoshi、Ohrui Sayaka、Okada Takahiro、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorg Med Chem.
  
  Volume: 27 Pages: 17471758-17471758
- DOI
  10.1016/j.bmc.2019.03.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-18K11014, KAKENHI-PROJECT-19K07314, KAKENHI-PROJECT-18K14352
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity2019
- Author(s)
  Saitoh T, Seki K, Nakajima R, Yamamoto N, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 29 Pages: 2655-2658
- DOI
  10.1016/j.bmcl.2019.07.039
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07314, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-18K14352
[Journal Article] Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats2018
- Author(s)
  Toyama, S., Shimoyama N, Tagaito Y., Nagase H., Saitoh T., Yanagisawa M., and Shimoyama, M.
- Journal Title
  
  Anesthesiology: The Journal of the American Society of Anesthesiologists
  
  Volume: 128 Pages: 992-1003
- DOI
  10.1097/aln.0000000000002161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10985, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-15K16557
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity2018
- Author(s)
  Ohrui Sayaka、Yamamoto Naoshi、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 28 Pages: 774-777
- DOI
  10.1016/j.bmcl.2017.12.069
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-15K16557, KAKENHI-PROJECT-16H05098
[Journal Article] オレキシン受容体を標的としたナルコレプシー治療薬の開発2018
- Author(s)
  斉藤毅、長瀬博
- Journal Title
  
  バイオサイエンスとインダストリー（B&I）
  
  Volume: 76 Pages: 127-129
- NAID
  40021512201
- Data Source
  KAKENHI-PROJECT-16H05098
[Journal Article] オレキシン研究の進展と新規受容体作動薬の創製2018
- Author(s)
  斉藤毅，長瀬博
- Journal Title
  
  バイオサイエンスとインダストリー(B&I)
  
  Volume: 76 Pages: 127-29
- Data Source
  KAKENHI-PROJECT-15K16557
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor2017
- Author(s)
  Yamamoto Naoshi、Ohrui Sayaka、Okada Takahiro、Yata Masahiro、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorganic & medicinal chemistry letters
  
  Volume: 27 Pages: 4176-4179
- DOI
  10.1016/j.bmcl.2017.07.011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-15K16557, KAKENHI-PROJECT-16H05098
[Journal Article] Design and Synthesis of Potent and Highly Selective Orexin1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies.2017
- Author(s)
  Nagase H and Yanagisawa M et al.
- Journal Title
  
  Journal of Medicinal Chemistory
  
  Volume: 60 Pages: 1018-1040
- DOI
  10.1021/acs.jmedchem.6b01418
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-15H05935, KAKENHI-PROJECT-26220207, KAKENHI-PROJECT-16H05098, KAKENHI-PROJECT-15H06606, KAKENHI-PROJECT-15K19195
[Journal Article] Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models2017
- Author(s)
  Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M.
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: 114 Pages: 5731-5736
- DOI
  10.1073/pnas.1700499114
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-16H06400, KAKENHI-PROJECT-15H03122, KAKENHI-PROJECT-15K16557, KAKENHI-PROJECT-16H05098
[Journal Article] IIIS発　ナルコレプシー治療薬開発に向けた取り組み2017
- Author(s)
  斉藤毅，入鹿山容子，柳沢正史，長瀬博
- Journal Title
  
  なるこ
  
  Volume: 34 Pages: 8-10
- Data Source
  KAKENHI-PROJECT-15K16557
[Journal Article] IIIS発　ナルコレプシー治療薬開発に向けた取り組み2017
- Author(s)
  斉藤毅、入鹿山容子、柳沢正史、長瀬博
- Journal Title
  
  なるこ
  
  Volume: 34 Pages: 8-10
- Data Source
  KAKENHI-PROJECT-16H05098
[Journal Article] The application of a specific morphinan template to the synthesis of galanthamine2017
- Author(s)
  Yamamoto Naoshi、Okada Takahiro、Harada Yukimasa、Kutsumura Noriki、Imaide Satomi、Saitoh Tsuyoshi、Fujii Hideaki、Nagase Hiroshi
- Journal Title
  
  Tetrahedron
  
  Volume: 73 Pages: 5751-5758
- DOI
  10.1016/j.tet.2017.08.014
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05098
[Journal Article] 睡眠覚醒を制御する世界初の分子：オレキシン２受容体作動薬YNT-185の創製2016
- Author(s)
  斉藤　毅，長瀬　博
- Journal Title
  
  和光純薬時報
  
  Volume: 84 Pages: 2-5
- Data Source
  KAKENHI-PROJECT-16H05098
[Journal Article] 低分子オレキシン受容体アゴニストの創製2016
- Author(s)
  斉藤　毅，長瀬　博
- Journal Title
  
  MEDCHEM NEWS
  
  Volume: 26 Pages: 90-96
- NAID
  130007383316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05098
[Journal Article] 低分子オレキシン受容体アゴニストの創製2016
- Author(s)
  斉藤毅、長瀬博
- Journal Title
  
  MEDCHEM NEWS
  
  Volume: 26 Pages: 90-96
- NAID
  130007383316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K16557
[Journal Article] Design and synthesis of non-peptide, selective orexin receptor 2 agonists2015
- Author(s)
  Nagahara T, Saitoh T, Kutsumura N, Irukayama-Tomobe Y, Ogawa Y, Kuroda D, Gouda H, Kumagai H, Fujii H, Yanagisawa M, Nagase H
- Journal Title
  
  J Med Chem.
  
  Volume: 58 Pages: 7931-37
- DOI
  10.1021/acs.jmedchem.5b00988
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-15K16557, KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-26220207
[Journal Article] Conophylline suppresses pancreatic stellate cells and improves islet fibrosis in Goto-Kakizaki rats2012
- Author(s)
  R.Saito, K.Umezawa, et al
- Journal Title
  
  Endocrinology
  
  Volume: 153 Pages: 621-630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Design and synthesis of biotinylated DHMEQ for direct identification of its target NF-κB components., 20112011
- Author(s)
  T.Saitoh, K.Umezawa, et al
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 21 Pages: 6293-6296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Patent] スルホンアミド誘導体またはその薬学的に許容される酸付加塩2017
- Inventor(s)
  長瀬博、斉藤毅、柳沢正史、入鹿山容子
- Industrial Property Rights Holder
  長瀬博、斉藤毅、柳沢正史、入鹿山容子
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Development of small molecules which regulate the sleep/wake cycle2020
- Author(s)
  T. Saitoh
- Organizer
  The 140th Annual Meeting of the Pharmacological Society of Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14352
[Presentation] In vitro and in vivo pharmacology of small-molecule orexin agonists for treatment of narcolepsy2019
- Author(s)
  1.Namekawa Y, Irukayama-Tomobe Y, Ishikawa Y, Yamaguchi T, Ogawa Y, Nemoto T, Tanaka H, Yamamoto H, Tito Akindele, Saitoh T, Nagase H, Yanagisawa M
- Organizer
  Tsukuba Global Science Week
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11014
[Presentation] Development of photocaged adenosine 2A receptor activator2019
- Author(s)
  Tsuyoshi Saitoh, Shuji Ioka, Mustafa Korkutata, Yohei Chitose, Manabu Abe, Michael Lazarus, Hiroshi Nagase
- Organizer
  13th International Symposium on Organic Reactions (ISOR-13)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14352
[Presentation] アデノシン2A受容体を標的とした新規光ケージド薬物の創製2019
- Author(s)
  斉藤毅、井岡秀二、Mustafa Korkutata、千歳洋平、Kaspar Vogt、安倍学、Michael Lazarus、長瀬博
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-18K14352
[Presentation] 新規低分子量オレキシン2型受容体作動薬、YNT-Xの薬理作用2019
- Author(s)
  滑川由紀子、入鹿山容子、小川靖裕、石川由紀子、山口拓土、アキンデレチト、斉藤毅、長瀬博、柳沢正史
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K14352
[Presentation] Essential structure of orexin 1 receptor antagonist YNT-7072019
- Author(s)
  S. Ohrui, N. Yamamoto, T. Okada, M. Yata, T. Saitoh, N. Kutsumura, Y. Nagumo, Y. Irukayama-Tomobe, Y. Ishikawa, Y. Ogawa, Y. Watanabe, D. Hayakawa, H. Gouda, M. Yanagisawa, H. Nagase
- Organizer
  27th International Society of Heterocyclic Chemistry Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14352
[Presentation] Discovery of Novel Orexin Receptor Antagonists with 1,3,5-Trioxazatriquinane Skeleton2019
- Author(s)
  M. Amezawa, J. Horiuchi, T. Saitoh, R. Ohshita, Y. Ogawa, Y. Ishikawa, Y. Irukayama, E. Hasegawa, D. Hayakawa, Y. Watanabe, Y. Nagumo, N. Yamamoto, N. Kutsumura, H. Gouda, T. Sakurai, M. Yanagisawa, H. Nagase
- Organizer
  The 27th French-Japanese Symposium on Medicinal and Fine Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14352
[Presentation] Essential structure of orexin 1 receptor antagonist YNT-7072019
- Author(s)
  2.Ohrui S, Yamamoto N, Okada T, Yata M, Saitoh T, Kutsumura N, Nagumo N, Irukayama-Tomobe Y, Ishikawa Y, Ogawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H.
- Organizer
  27th International Society of HeterocyclicChemistry Congress ROHM Theatre Kyoto & Miyakomesse
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11014
[Presentation] Discovery of Novel Orexin Receptor Antagonist with 1,3,5-Trioxazatriquinane Skeleton2019
- Author(s)
  3.Amezawa M, Horiuchi J, Saitoh T, Ogawa Y, Ishikawa Y, Irukayama Y, Hasegawa E, Hayakawa D, Watanabe Y, Nagumo Y, Yamamoto N, Kutsumura N, Gouda H, Sakurai T, Yanagisawa M, Nagase H.
- Organizer
  The 27th French-Japanese Symposium on Medicinal and Fine Chemistry Hotel Leopalace Hakata
- Data Source
  KAKENHI-PROJECT-18K11014
[Presentation] Non-peptidic Orexin receptor type-2 agonist attenuates body weight gain of high-fat fed mice2018
- Author(s)
  1.Eriya Takahashi*, Kyoko Enomoto, Takuto Yamaguchi, Yasuhiro Ogawa, Shoji Fukusumi, Akari Kawai, Masaya Araki, Tsuyoshi Saitoh, Yoshimi Nakagawa, Yoko Irukayama-Tomobe, Hitoshi Shimano, Hiroshi Nagase, Masashi Yanagisawa
- Organizer
  The 41st Annual Meeting of the Japan Neuroscience Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11014
[Presentation] 光ケージドadenosine 2A受容体ポジティブアロステリックモジュレーターの開発2018
- Author(s)
  井岡秀二、斉藤毅、千歳洋平、Mustafa Korkutata、安部学、Michael Lazarus、長瀬博
- Organizer
  日本ケミカルバイオロジー学会第13回年会
- Data Source
  KAKENHI-PROJECT-18K14352
[Presentation] キャップトリマー骨格を有するオレキシン受容体拮抗薬の設計・合成12017
- Author(s)
  堀内惇平、大下隆一郎、南雲康行、山本直司、沓村憲樹、斉藤毅、入鹿山容子、石川有紀子、小川靖裕、柳沢正史、長瀬博
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] 睡眠覚醒を標的とする創薬研究2017
- Author(s)
  斉藤毅
- Organizer
  第4回次世代の有機化学・広島シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] キャップトリマー骨格を有するオレキシン受容体拮抗薬の設計・合成22017
- Author(s)
  大下隆一郎、堀内惇平、南雲康行、山本直司、沓村憲樹、斉藤毅、入鹿山容子、石川有紀子、小川靖裕、柳沢正史、長瀬博
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] オレキシン１受容体拮抗薬YNT-707の必須構造部位検討2017
- Author(s)
  大類彩、山本直司、岡田卓大、谷田誠浩、斉藤毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、渡邊友里恵、早川大地、合田浩明、柳沢正史、長瀬博
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] Design and synthesis of orexin 1 receptor selective antagonists2017
- Author(s)
  Sayaka Ohrui, Naoshi Yamamoto, Masahiro Yata, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Shigeto Hirayama, Masashi Yanagisawa, Hiroshi Nagase
- Organizer
  Tsukuba Global Science Week (TGSW) 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] 睡眠覚醒を標的とする創薬研究2017
- Author(s)
  斉藤毅
- Organizer
  第４回次世代の有機化学・広島シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] モルヒナン骨格を有するオレキシン1受容体（OX1R）の特異的拮抗薬の設計・合成とOX1R結合の活性立体配座2017
- Author(s)
  山本直司、大類彩、岡田卓大、谷田誠浩、斉藤毅、沓村憲樹、南雲康行、入鹿山容子、小川靖裕、石川有紀子、平山重人、渡辺友里恵、早川大地、合田浩明、柳沢正史、長瀬博
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Design and synthesis of orexin 1 receptor selective antagonists2017
- Author(s)
  Sayaka Ohrui, Naoshi Yamamoto, Masahiro Yata, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Shigeto Hirayama, Masashi Yanagisawa, Hiroshi Nagase
- Organizer
  Tsukuba Global Science Week (TGSW) 2017
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] 新規低分子量オレキシン受容体作動薬YNT-185の全身炎症後の活動回復作用の検討2017
- Author(s)
  内田　俊太郎、入鹿山　容子、小川　靖裕、富永　拡、石川　ゆい、木山　麻衣子、斉藤　毅、長瀬　博、柳沢　正史
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎新聞文化ホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] 大学における創薬研究とクロマトグラフィー2017
- Author(s)
  斉藤毅
- Organizer
  分取クロマトセミナー2017
- Invited
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] モルヒナン骨格を有するオレキシン1受容体（OX1R）の特異的拮抗薬の設計・合成とOX1R結合の活性立体配座2017
- Author(s)
  山本直司、大類彩、岡田卓大、谷田誠浩、斉藤毅、沓村憲樹、南雲康行、入鹿山容子、小川靖裕、石川有紀子、平山重人、渡辺友里恵、早川大地、合田浩明、柳沢正史、長瀬博
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] 低分子量オレキシン受容体2型作動薬YNT-185の組織学的、及び電気生理学的解析2017
- Author(s)
  小川　靖裕、入鹿山　容子、富永　拡、細川　直人、斉藤　毅、長瀬　博、柳沢　正史
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎新聞文化ホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] オレキシン１受容体拮抗薬YNT-707の必須構造部位検討2017
- Author(s)
  大類彩、山本直司、岡田卓大、谷田誠浩、斉藤毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、渡邊友里恵、早川大地、合田浩明、柳沢正史、長瀬博
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] YNT-707のOX1Rアンタゴニスト活性発現のための必須構造の検討2016
- Author(s)
  関　知範、中嶋　龍、斉藤　毅、入鹿山容子、小川靖裕、石川有紀子、柳沢正史、長瀬　博
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] 低分子オレキシン受容体アゴニストの創製2016
- Author(s)
  斉藤　毅、永原崇志、沓村憲樹、入鹿山容子、小川靖裕、富永　拡、黒田大介、合田浩明、藤井秀明、柳沢正史、長瀬　博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Invited
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] モルヒナン骨格を有する新規オレキシン1受容体選択的拮抗薬の設計・合成②2016
- Author(s)
  岡田卓大、山本直司、谷田誠浩、大類　彩、斉藤　毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、平山重人、柳沢正史、長瀬　博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Synthesis of Novel, Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton2016
- Author(s)
  Naoshi Yamamoto, Masahiro Yata, Sayaka Ohrui, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Daisuke Kuroda, Hiroaki Gouda, Masashi Yanagisawa, Hiroshi Nagase
- Organizer
  The 25th French-Japanese Symposium on Medicinal and Fine Chemistry
- Place of Presentation
  Keio Plaza Hotel Tama（東京都多摩市）
- Year and Date
  2016-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] オレキシン2受容体作動薬の設計・合成2016
- Author(s)
  長瀬　博、永原　崇志、斉藤　毅、沓村　憲樹、入鹿山　容子、小川　靖裕、黒田　大祐、合田　浩明、藤井　秀明、柳沢　正史
- Organizer
  第36回鎮痛薬・オピオイドペプチドシンポジウム
- Place of Presentation
  北海道大学（北海道札幌市）
- Year and Date
  2016-08-19
- Invited
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] モルヒナン骨格を有する新規オレキシン1受容体選択的拮抗薬の設計・合成①2016
- Author(s)
  大類　彩、山本直司、谷田誠浩、岡田卓大、斉藤　毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、柳沢正史、長瀬　博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] オレキシン２受容体作動薬YNT-185の創製2016
- Author(s)
  斉藤　毅、永原崇志、沓村憲樹、中嶋　龍、細川直人、入鹿山容子、小川靖裕、富永　拡、黒田大介、合田浩明、藤井秀明、柳沢正史、長瀬　博
- Organizer
  第34回メディシナルケミストリーシンポジウム　サテライトセッション
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] ナルフラフィンの構造を基にしたオレキシン1受容体選択的拮抗薬の設計・合成およびその薬理作用2016
- Author(s)
  山本直司、谷田誠浩、大類　彩、岡田卓大、斉藤　毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、平山重人、柳沢正史、長瀬　博
- Organizer
  第36回鎮痛薬・オピオイドペプチドシンポジウム
- Place of Presentation
  北海道大学（北海道札幌市）
- Year and Date
  2016-06-19
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] YNT-707のOX1R拮抗作用発現のための必須構造の検討2016
- Author(s)
  関　知範、中嶋　龍、斉藤　毅、入鹿山容子、小川靖裕、石川有紀子、柳沢正史、長瀬　博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] モルヒナン骨格を有するオレキシン１受容体選択的拮抗薬の設計・合成とその薬理作用”2016
- Author(s)
  大類　彩、山本直司、谷田誠浩、岡田卓大、斉藤　毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、平山重人、柳沢正史、長瀬　博
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Development of non-peptide orexin receptor agonists for controlling sleep/wake cycle2016
- Author(s)
  Tsuyoshi Saitoh, Takashi Nagahara, Noriki Kutsumura, Yoko Irukayama, Yasuhiro Ogawa, Daisuke Kuroda, Hiroaki Gouda, Hideaki Fujii, Masashi Yanagisawa, Hiroshi Nagase
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  同志社大学京田辺キャンパス、京都府、京都市
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] 低分子オレキシン受容体アゴニストの創製2015
- Author(s)
  斉藤毅、永原崇志、沓村憲樹、入鹿山容子、小川靖裕、黒田大祐、合田浩明、藤井秀明、柳沢正史、長瀬博
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研修センター、千葉県、千葉市
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] Discovery of novel orexin receptor agonists for controlling sleep/awake cycle2015
- Author(s)
  T. Saitoh, T. Nagahara, N. Kutsumura, Y. Irukayama, Y. Ogawa, H. Fujii, M. Yanagisawa, H. Nagase
- Organizer
  Pacifichem 2015
- Place of Presentation
  ヒルトンハワイアンビレッジ、ホノルル、アメリカ
- Year and Date
  2015-12-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16557

1. Nagase Hiroshi (70383651)

# of Collaborated Projects: 2 results

# of Collaborated Products: 28 results
2. Yanagisawa Masashi (20202369)

# of Collaborated Projects: 2 results

# of Collaborated Products: 27 results
3. Suno Ryoji (60447521)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 入鹿山容子 (90312834)

# of Collaborated Projects: 2 results

# of Collaborated Products: 29 results
5. 南雲康行 (00459661)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. UMEZAWA Kazuo (70114402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SIMIZU Siro (30312268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ISHIKAWA Yuichi (40348826)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OZAKI Michitaka (80256510)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HAGA Sanae (60706505)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KOBAYASHI Takuya (20311730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 桜井武 (60251055)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. ラザルスミハエル (80469650)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 高田陽子 (60435740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 大石陽 (70554004)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 野村紀通 (10314246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 福住昌司 (10750002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 櫻井勝康 (70507920)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. Kobilka Brian K

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 黒田大祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 下山恵美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 熊谷英敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 梅沢一夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

SAITOH Tsuyoshi 斉藤 毅

Saitoh Tsuyoshi 斎藤 毅

SAITO Tsuyoshi 斉藤 毅

Research Projects

Research Products

Co-Researchers

Multi-scale platform for untangling physiological complexityArea Organizer

Area Organizer

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マルチスケールな生理作用の因数分解基盤構築の支援Principal Investigator

Principal Investigator

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モルヒナン骨格を基盤とした三次元的フォーカスドライブラリーの構築Principal Investigator

Principal Investigator

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Research Institution

Development of novel selective orexin 1 receptor agonists and elucidation of the function of orexin receptors

Principal Investigator

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Review Section

Research Institution

Development of novel PET probes targeting orexin 1 receptorPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Structural analysis of G protein/Arrestin-GPCR complex for development of biased ligands

Principal Investigator

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オレキシン２型受容体作動薬による代謝リズム調節機構の解明

Principal Investigator

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Development of novel photochemical tools to regulate wakefulnessPrincipal Investigator

Principal Investigator

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Review Section

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The role of the nucleus accumbens in regulating slow-wave sleep by motivated behavior

Principal Investigator

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Development of novel orexin ligand and its pharmacological activity

Principal Investigator

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Development of novel molecular tool for controlling sleep/wake cycle and feeding behaviorPrincipal Investigator

Principal Investigator

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Differential analysis of the crystal structures of active / inactive orexin receptor contributing to rational development of sleep control drug

Principal Investigator

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Research Institution

Bio-imaging of peritoneal metastasis and molecular design of inhibitors

Principal Investigator

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SAITOH Tsuyoshi 斉藤毅

Saitoh Tsuyoshi 斎藤毅

SAITO Tsuyoshi 斉藤毅

[Journal Article] IIIS発　ナルコレプシー治療薬開発に向けた取り組み2017

[Journal Article] IIIS発　ナルコレプシー治療薬開発に向けた取り組み2017