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SAITOH Tsuyoshi  斉藤 毅

… Alternative Names

Saitoh Tsuyoshi  斎藤 毅

SAITO Tsuyoshi  斉藤 毅

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Researcher Number 80609933
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-6105-6292
Affiliation (Current) 2022: 筑波大学, 国際統合睡眠医科学研究機構, 助教
Affiliation (based on the past Project Information) *help 2015 – 2022: 筑波大学, 国際統合睡眠医科学研究機構, 助教
2013: 慶應義塾大学, 理工学部, 助教
2012: 筑波大学, 学内共同利用施設等, 助教
2011: 慶應義塾大学, 理工学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 37030:Chemical biology-related / Transformative Research Areas, Section (II) / Chemical biology
Except Principal Investigator
Chemical biology / Drug development chemistry / Basic / Social brain science / General medical chemistry / Basic Section 59040:Nutrition science and health science-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Basic Section 48040:Medical biochemistry-related / Biological Sciences
Keywords
Principal Investigator
作動薬 / 神経科学 / オレキシン / 睡眠覚醒 / ケージド化合物 / 脳・神経 / 拮抗薬 / GPCR / 創薬化学 / 光ケージド薬物 … More / 光反応 / ケミカルバイオロジー / 有機合成化学 / 光ケージド化合物 / 睡眠 / 覚醒 / スイッチング化合物 / 合成化学 / 有機化学 / オレキシン受容体 / PETプローブ / オピオイド / 構造生物学 / シグナル伝達 / 薬理学 / オピオイド受容体 … More
Except Principal Investigator
睡眠 / ナルコレプシー / GPCR / オレキシン / 作動薬 / オレキシン受容体 / シグナル伝達 / X線結晶構造解析 / 薬剤開発 / 膜タンパク質 / 創薬 / 分子デザイン / バイオイメージング / 腹腔内転移 / 浸潤 / 遊走 / NF-kappa B / DHMEQ / DTCM-glutarimide / migracin / Exo-ene EQ / pyrapaxilline / 卵巣がん / 転移 / アノイキス / メラノーマ / 卵巣癌 / NF-κB / 探索プローブ / 標的タンパク質 / 光プローブ / オピオイド / モルヒナン / 拮抗薬 / OX1R作動薬 / モルフィナン骨格 / OX1R拮抗薬 / OX2R作動薬 / 創薬化学 / 有機合成化学 / ナルフラフィン / 覚醒 / sleep / motivation / nucleus accumbens / Nucleus accumbens / Sleep / Motivation / Nucleus Accumbens / ヒト膜受容体 / 抗体 / 機能性抗体 / オレキシン受容体作動薬 / アゴニスト / オレキシン1受容体 / 薬理評価 / 機能解明 / クライオ電子顕微鏡単粒子解析 / バイアスドリガンド / SBDD / クライオ電子顕微鏡 / バイアスリガンド Less
  • Research Projects

    (14 results)
  • Research Products

    (81 results)
  • Co-Researchers

    (34 People)
  •  Deciphering the mysteries of sleep:creating a global network of sleep neurobiologists

    • Principal Investigator
      柳沢 正史
    • Project Period (FY)
      2022 – 2028
    • Research Category
      Fund for the Promotion of Joint International Research (International Leading Research )
    • Review Section
      Biological Sciences
    • Research Institution
      University of Tsukuba
  •  Multi-scale platform for untangling physiological complexityArea Organizer

    • Area Organizer
      斉藤 毅
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
  •  Multi-scale platform for untangling physiological complexityPrincipal Investigator

    • Principal Investigator
      斉藤 毅
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (II)
    • Research Institution
      University of Tsukuba
  •  Construction of morphinan-based focused libraryPrincipal Investigator

    • Principal Investigator
      斉藤 毅
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (II)
    • Research Institution
      University of Tsukuba
  •  Development of novel selective orexin 1 receptor agonists and elucidation of the function of orexin receptors

    • Principal Investigator
      長瀬 博
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
    • Research Institution
      University of Tsukuba
  •  Development of novel PET probes targeting orexin 1 receptorPrincipal Investigator

    • Principal Investigator
      斉藤 毅
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 37030:Chemical biology-related
    • Research Institution
      University of Tsukuba
  •  Structural analysis of G protein/Arrestin-GPCR complex for development of biased ligands

    • Principal Investigator
      寿野 良二
    • Project Period (FY)
      2019 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      Kansai Medical University
  •  Elucidation of metabolic rhythm regulation by orexin agonist

    • Principal Investigator
      Fukusumi Shoji
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      University of Tsukuba
  •  Development of novel photochemical tools to regulate wakefulnessPrincipal Investigator

    • Principal Investigator
      Tsuyoshi Saitoh
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 37030:Chemical biology-related
    • Research Institution
      University of Tsukuba
  •  The role of the nucleus accumbens in regulating slow-wave sleep by motivated behavior

    • Principal Investigator
      Lazarus Michael
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Basic / Social brain science
    • Research Institution
      University of Tsukuba
  •  Development of novel orexin ligand and its pharmacological activity

    • Principal Investigator
      Nagase Hiroshi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      University of Tsukuba
  •  Differential analysis of the crystal structures of active / inactive orexin receptor contributing to rational development of sleep control drug

    • Principal Investigator
      Suno Ryoji
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Kyoto University
  •  Development of novel molecular tool for controlling sleep/wake cycle and feeding behaviorPrincipal Investigator

    • Principal Investigator
      SAITOH Tsuyoshi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Chemical biology
    • Research Institution
      University of Tsukuba
  •  Bio-imaging of peritoneal metastasis and molecular design of inhibitors

    • Principal Investigator
      UMEZAWA Kazuo
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Chemical biology
    • Research Institution
      Aichi Medical University
      Keio University

All 2022 2021 2020 2019 2018 2017 2016 2015 2012 2011

All Journal Article Presentation Patent

  • [Journal Article] Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring2022

    • Author(s)
      Keita Iio, Tsuyoshi Saitoh, Ryuichiro Ohshita, Tsubasa Hino, Mao Amezawa, Yoshiaki Takayama, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kustumura, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase
    • Journal Title

      Bioorg Med Chem Lett.

      Volume: 60 Pages: 128555-128555

    • DOI

      10.1016/j.bmcl.2022.128555

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-21H05111, KAKENHI-PROJECT-20H03361, KAKENHI-PROJECT-19K07314
  • [Journal Article] Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton2022

    • Author(s)
      Tsubasa Hino, Tsuyoshi Saitoh, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase
    • Journal Title

      Bioorg Med Chem Lett.

      Volume: 59 Pages: 128530-128530

    • DOI

      10.1016/j.bmcl.2022.128530

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-21H05111, KAKENHI-PROJECT-20H03361, KAKENHI-PROJECT-19K07314
  • [Journal Article] Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands2022

    • Author(s)
      Iio Keita、Kutsumura Noriki、Nagumo Yasuyuki、Saitoh Tsuyoshi、Tokuda Akihisa、Hashimoto Kao、Yamamoto Naoshi、Kise Ryoji、Inoue Asuka、Mizoguchi Hirokazu、Nagase Hiroshi
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 56 Pages: 128485-128485

    • DOI

      10.1016/j.bmcl.2021.128485

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K05710, KAKENHI-PUBLICLY-20H04763, KAKENHI-ORGANIZER-21H05111, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-21K06602
  • [Journal Article] Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses the three active conformations of nalfurafine2020

    • Author(s)
      Nagumo Yasuyuki、Katoh Koki、Iio Keita、Saitoh Tsuyoshi、Kutsumura Noriki、Yamamoto Naoshi、Ishikawa Yukiko、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Baba Takeshi、Tanimura Ryuji、Yanagisawa Masashi、Nagase Hiroshi
    • Journal Title

      Bioorg Med Chem Lett.

      Volume: 30 Pages: 127360-127360

    • DOI

      10.1016/j.bmcl.2020.127360

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K05710, KAKENHI-PROJECT-19K07314, KAKENHI-ORGANIZER-15H05935, KAKENHI-WRAPUP-20H05615, KAKENHI-PROJECT-18K11014
  • [Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group.2020

    • Author(s)
      Saitoh T, Seki K, Nakajima R, Yamamoto N, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H.
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 29 Pages: 126893-126893

    • DOI

      10.1016/j.bmcl.2019.126893

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K11014, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-18K14352
  • [Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring.2019

    • Author(s)
      Yamamoto Naoshi、Ohrui Sayaka、Okada Takahiro、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
    • Journal Title

      Bioorg Med Chem.

      Volume: 27 Pages: 17471758-17471758

    • DOI

      10.1016/j.bmc.2019.03.010

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-18K11014, KAKENHI-PROJECT-19K07314, KAKENHI-PROJECT-18K14352, KAKENHI-PROJECT-16H05098
  • [Journal Article] Enhancing endogenous adenosine A2A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function2019

    • Author(s)
      Korkutata M, Saitoh T, Cherasse Y, Ioka S, Duo F, Qin R, Murakoshi N, Fujii S, Zhou X, Sugiyama F, Chen JF, Kumagai H, Nagase H, Lazarus M
    • Journal Title

      Neuropharmacology

      Volume: 144 Pages: 122-132

    • DOI

      10.1016/j.neuropharm.2018.10.022

    • NAID

      120007128264

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PUBLICLY-18H04966, KAKENHI-PROJECT-17H02215, KAKENHI-PROJECT-16K18698
  • [Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity2019

    • Author(s)
      Saitoh T, Seki K, Nakajima R, Yamamoto N, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H.
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 29 Pages: 2655-2658

    • DOI

      10.1016/j.bmcl.2019.07.039

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07314, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-18K14352
  • [Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity2018

    • Author(s)
      Ohrui Sayaka、Yamamoto Naoshi、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 28 Pages: 774-777

    • DOI

      10.1016/j.bmcl.2017.12.069

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06095, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-15K16557, KAKENHI-PROJECT-16H05098
  • [Journal Article] Favorskii-Type Rearrangement of the 4,5-Epoxymorphinan Skeleton2018

    • Author(s)
      Kutsumura Noriki、Koyama Yasuaki、Suzuki Yuko、Tominaga Ken-ichi、Yamamoto Naoshi、Saitoh Tsuyoshi、Nagumo Yasuyuki、Nagase Hiroshi
    • Journal Title

      Organic Letters

      Volume: 20 Pages: 1559-1562

    • DOI

      10.1021/acs.orglett.8b00288

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K13259, KAKENHI-PROJECT-16H05098
  • [Journal Article] Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats2018

    • Author(s)
      Toyama, S., Shimoyama N, Tagaito Y., Nagase H., Saitoh T., Yanagisawa M., and Shimoyama, M.
    • Journal Title

      Anesthesiology: The Journal of the American Society of Anesthesiologists

      Volume: 128 Pages: 992-1003

    • DOI

      10.1097/aln.0000000000002161

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K10985, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-15K16557, KAKENHI-PROJECT-16H05098
  • [Journal Article] オレキシン受容体を標的としたナルコレプシー治療薬の開発2018

    • Author(s)
      斉藤毅、長瀬博
    • Journal Title

      バイオサイエンスとインダストリー(B&I)

      Volume: 76 Pages: 127-129

    • NAID

      40021512201

    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Journal Article] オレキシン研究の進展と新規受容体作動薬の創製2018

    • Author(s)
      斉藤毅,長瀬博
    • Journal Title

      バイオサイエンスとインダストリー(B&I)

      Volume: 76 Pages: 127-29

    • Data Source
      KAKENHI-PROJECT-15K16557
  • [Journal Article] Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models2017

    • Author(s)
      Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M.
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 114 Pages: 5731-5736

    • DOI

      10.1073/pnas.1700499114

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-16H06400, KAKENHI-PROJECT-15H03122, KAKENHI-PROJECT-15K16557, KAKENHI-PROJECT-16H05098
  • [Journal Article] IIIS発 ナルコレプシー治療薬開発に向けた取り組み2017

    • Author(s)
      斉藤毅、入鹿山容子、柳沢正史、長瀬博
    • Journal Title

      なるこ

      Volume: 34 Pages: 8-10

    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Journal Article] IIIS発 ナルコレプシー治療薬開発に向けた取り組み2017

    • Author(s)
      斉藤毅,入鹿山容子,柳沢正史,長瀬博
    • Journal Title

      なるこ

      Volume: 34 Pages: 8-10

    • Data Source
      KAKENHI-PROJECT-15K16557
  • [Journal Article] The application of a specific morphinan template to the synthesis of galanthamine2017

    • Author(s)
      Yamamoto Naoshi、Okada Takahiro、Harada Yukimasa、Kutsumura Noriki、Imaide Satomi、Saitoh Tsuyoshi、Fujii Hideaki、Nagase Hiroshi
    • Journal Title

      Tetrahedron

      Volume: 73 Pages: 5751-5758

    • DOI

      10.1016/j.tet.2017.08.014

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor2017

    • Author(s)
      Yamamoto Naoshi、Ohrui Sayaka、Okada Takahiro、Yata Masahiro、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
    • Journal Title

      Bioorganic & medicinal chemistry letters

      Volume: 27 Pages: 4176-4179

    • DOI

      10.1016/j.bmcl.2017.07.011

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-15K16557, KAKENHI-PROJECT-16H05098
  • [Journal Article] Design and Synthesis of Potent and Highly Selective Orexin1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies.2017

    • Author(s)
      Nagase H and Yanagisawa M et al.
    • Journal Title

      Journal of Medicinal Chemistory

      Volume: 60 Pages: 1018-1040

    • DOI

      10.1021/acs.jmedchem.6b01418

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-ORGANIZER-15H05935, KAKENHI-PROJECT-26220207, KAKENHI-PROJECT-16H05098, KAKENHI-PROJECT-15H06606, KAKENHI-PROJECT-15K19195, KAKENHI-PROJECT-15K16557
  • [Journal Article] 睡眠覚醒を制御する世界初の分子:オレキシン2受容体作動薬YNT-185の創製2016

    • Author(s)
      斉藤 毅,長瀬 博
    • Journal Title

      和光純薬時報

      Volume: 84 Pages: 2-5

    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Journal Article] 睡眠覚醒を制御する世界初の分子:オレキシン2受容体作動薬YNT-185の創製2016

    • Author(s)
      斉藤 毅,長瀬 博
    • Journal Title

      和光純薬時報

      Volume: 84 Pages: 2-5

    • Data Source
      KAKENHI-PROJECT-15K16557
  • [Journal Article] 低分子オレキシン受容体アゴニストの創製2016

    • Author(s)
      斉藤 毅,長瀬 博
    • Journal Title

      MEDCHEM NEWS

      Volume: 26 Pages: 90-96

    • NAID

      130007383316

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K16557
  • [Journal Article] 低分子オレキシン受容体アゴニストの創製2016

    • Author(s)
      斉藤 毅,長瀬 博
    • Journal Title

      MEDCHEM NEWS

      Volume: 26 Pages: 90-96

    • NAID

      130007383316

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Journal Article] Design and synthesis of non-peptide, selective orexin receptor 2 agonists2015

    • Author(s)
      Nagahara T, Saitoh T, Kutsumura N, Irukayama-Tomobe Y, Ogawa Y, Kuroda D, Gouda H, Kumagai H, Fujii H, Yanagisawa M, Nagase H
    • Journal Title

      J Med Chem.

      Volume: 58 Pages: 7931-37

    • DOI

      10.1021/acs.jmedchem.5b00988

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-15K16557, KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-26220207
  • [Journal Article] Conophylline suppresses pancreatic stellate cells and improves islet fibrosis in Goto-Kakizaki rats2012

    • Author(s)
      R.Saito, K.Umezawa, et al
    • Journal Title

      Endocrinology

      Volume: 153 Pages: 621-630

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Design and synthesis of biotinylated DHMEQ for direct identification of its target NF-κB components., 20112011

    • Author(s)
      T.Saitoh, K.Umezawa, et al
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 21 Pages: 6293-6296

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Patent] スルホンアミド誘導体またはその薬学的に許容される酸付加塩2017

    • Inventor(s)
      長瀬博、斉藤毅、柳沢正史、入鹿山容子
    • Industrial Property Rights Holder
      長瀬博、斉藤毅、柳沢正史、入鹿山容子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] 分子の形に注目した創薬研究2022

    • Author(s)
      斉藤毅
    • Organizer
      日本薬学会第142年会
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-21H05111
  • [Presentation] Design and synthesis of 17-N-fluoroalkyl nalfurafine derivatives to improve pharmacological properties2021

    • Author(s)
      Natsumi Sakamoto; Tsuyoshi Saitoh; Yukiko Ishikawa; Akihisa Tokuda; Tsubasa Hino; Naoshi Yamamoto; Yasuyuki Nagumo; Noriki Kutsumura; Masashi Yanagisawa; Hiroshi Nagase
    • Organizer
      The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem)
    • Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-21H05111
  • [Presentation] Design and Synthesis of Novel Orexin Receptor Antagonists with 1,3,5-Trioxazatriquinane skeleton2021

    • Author(s)
      Mao Amezawa; Jumpei Horiuchi; Tsuyoshi Saitoh; Ryuichiro Ohshita; Naoshi Yamamoto; Yasuyuki Nagumo; Yukiko Ishikawa; Yoko Irukayama; Emi Hasegawa; Noriki Kutsumura; Ryuji Tanimura; Sakurai Takeshi; Masashi Yanagisawa; Hiroshi Nagase
    • Organizer
      AIMECS2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-21H05111
  • [Presentation] Discovery of novel orexin receptor antagonists with 1,3,5-trioxazatriquinane skeleton2021

    • Author(s)
      Mao Amezawa; Tsuyoshi Saitoh; Yukiko Ishikawa; Yoko Irukayama; Emi Hasegawa; Hiroaki Gouda; Naoshi Yamamoto; Noriki Kutsumura; Yasuyuki Nagumo; Sakurai Takeshi; Masashi Yanagisawa; Hiroshi Nagase
    • Organizer
      The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem)(国際学会)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03361
  • [Presentation] Design and Synthesis of Novel Orexin Receptor Dual Agonists with Tetralin Skeleton2021

    • Author(s)
      Keita Iio, Tsuyoshi Saitoh, Ryuichiro Ohshita, Tsubasa Hino, Mao Amezawa, Sayaka Ohrui, Takahiro Okada, Yasuyuki Nagumo, Naoshi Yamamoto, Yukiko Ishikawa, Yoko Irukayama-Tomobe, Noriki Kutsumura, Masashi Yanagisawa, Hiroshi Nagase
    • Organizer
      AIMECS2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-21H05111
  • [Presentation] Synthesis of unnatural morphinan compounds to induce itch like behavior in mice: Towards the development of MRGPRX2 selective ligands2021

    • Author(s)
      Keita Iio; Noriki Kutsumura; Yasuyuki Nagumo; Tsuyoshi Saitoh; Naoshi Yamamoto; Akihisa Tokuda; Kao Hashimoto; Hirokazu Mizoguchi; Hiroshi Nagase
    • Organizer
      The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem)
    • Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-21H05111
  • [Presentation] Discovery of novel orexin receptor antagonists with 1,3,5-trioxazatriquinane skeleton2021

    • Author(s)
      Mao Amezawa; Tsuyoshi Saitoh; Yukiko Ishikawa; Yoko Irukayama; Emi Hasegawa; Hiroaki Gouda; Naoshi Yamamoto; Noriki Kutsumura; Yasuyuki Nagumo; Sakurai Takeshi; Masashi Yanagisawa; Hiroshi Nagase
    • Organizer
      The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem)
    • Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-21H05111
  • [Presentation] Design and synthesis of novel morphinan-type κ opioid receptor agonists bearing bicyclo[2.2.2]octane skeleton and these pharmacological activities2021

    • Author(s)
      Keita Kajino; Masahiro Yata; Tsuyoshi Saitoh; Naoshi Yamamoto; Yasuyuki Nagumo; Tsubasa Hino; Akihisa Tokuda; Noriki Kutsumura; Hiroshi Nagase
    • Organizer
      The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem)
    • Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-21H05111
  • [Presentation] Design and Synthesis of Novel Orexin Receptor Antagonists with 1,3,5-Trioxazatriquinane skeleton2021

    • Author(s)
      Mao Amezawa; Jumpei Horiuchi; Tsuyoshi Saitoh; Ryuichiro Ohshita; Naoshi Yamamoto; Yasuyuki Nagumo; Yukiko Ishikawa; Yoko Irukayama; Emi Hasegawa; Noriki Kutsumura; Ryuji Tanimura; Sakurai Takeshi; Masashi Yanagisawa; Hiroshi Nagase
    • Organizer
      AIMECS2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03361
  • [Presentation] Design and Synthesis of Novel Orexin Receptor Dual Agonists with Tetralin Skeleton2021

    • Author(s)
      Keita Iio, Tsuyoshi Saitoh, Ryuichiro Ohshita, Tsubasa Hino, Mao Amezawa, Sayaka Ohrui, Takahiro Okada, Yasuyuki Nagumo, Naoshi Yamamoto, Yukiko Ishikawa, Yoko Irukayama-Tomobe, Noriki Kutsumura, Masashi Yanagisawa, Hiroshi Nagase
    • Organizer
      AIMECS2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03361
  • [Presentation] Why are we sleepy when bored? Astroglial regulation of sleep in the nucleus accumbens2020

    • Author(s)
      Xuzhao Zhou, Tsuyoshi Saitoh, Zhaofa Wu, Yulong Li, Michael Lazarus
    • Organizer
      Cold Spring Harbor Laboratory Meetings - Glia in Health & Disease (Virtual)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H02215
  • [Presentation] Development of small molecules which regulate the sleep/wake cycle2020

    • Author(s)
      T. Saitoh
    • Organizer
      The 140th Annual Meeting of the Pharmacological Society of Japan
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14352
  • [Presentation] In vitro and in vivo pharmacology of small-molecule orexin agonists for treatment of narcolepsy2019

    • Author(s)
      1.Namekawa Y, Irukayama-Tomobe Y, Ishikawa Y, Yamaguchi T, Ogawa Y, Nemoto T, Tanaka H, Yamamoto H, Tito Akindele, Saitoh T, Nagase H, Yanagisawa M
    • Organizer
      Tsukuba Global Science Week
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K11014
  • [Presentation] アデノシン2A受容体を標的とした新規光ケージド薬物の創製2019

    • Author(s)
      斉藤毅、井岡秀二、Mustafa Korkutata、千歳洋平、Kaspar Vogt、安倍学、Michael Lazarus、長瀬博
    • Organizer
      第37回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-18K14352
  • [Presentation] Essential structure of orexin 1 receptor antagonist YNT-7072019

    • Author(s)
      S. Ohrui, N. Yamamoto, T. Okada, M. Yata, T. Saitoh, N. Kutsumura, Y. Nagumo, Y. Irukayama-Tomobe, Y. Ishikawa, Y. Ogawa, Y. Watanabe, D. Hayakawa, H. Gouda, M. Yanagisawa, H. Nagase
    • Organizer
      27th International Society of Heterocyclic Chemistry Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14352
  • [Presentation] Discovery of Novel Orexin Receptor Antagonists with 1,3,5-Trioxazatriquinane Skeleton2019

    • Author(s)
      M. Amezawa, J. Horiuchi, T. Saitoh, R. Ohshita, Y. Ogawa, Y. Ishikawa, Y. Irukayama, E. Hasegawa, D. Hayakawa, Y. Watanabe, Y. Nagumo, N. Yamamoto, N. Kutsumura, H. Gouda, T. Sakurai, M. Yanagisawa, H. Nagase
    • Organizer
      The 27th French-Japanese Symposium on Medicinal and Fine Chemistry
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14352
  • [Presentation] Development of photocaged adenosine 2A receptor activator2019

    • Author(s)
      Tsuyoshi Saitoh, Shuji Ioka, Mustafa Korkutata, Yohei Chitose, Manabu Abe, Michael Lazarus, Hiroshi Nagase
    • Organizer
      13th International Symposium on Organic Reactions (ISOR-13)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14352
  • [Presentation] 新規低分子量オレキシン2型受容体作動薬、YNT-Xの薬理作用2019

    • Author(s)
      滑川由紀子、入鹿山容子、小川靖裕、石川由紀子、山口拓土、アキンデレ チト、斉藤毅、長瀬博、柳沢正史
    • Organizer
      第92回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-18K14352
  • [Presentation] Discovery of Novel Orexin Receptor Antagonist with 1,3,5-Trioxazatriquinane Skeleton2019

    • Author(s)
      3.Amezawa M, Horiuchi J, Saitoh T, Ogawa Y, Ishikawa Y, Irukayama Y, Hasegawa E, Hayakawa D, Watanabe Y, Nagumo Y, Yamamoto N, Kutsumura N, Gouda H, Sakurai T, Yanagisawa M, Nagase H.
    • Organizer
      The 27th French-Japanese Symposium on Medicinal and Fine Chemistry Hotel Leopalace Hakata
    • Data Source
      KAKENHI-PROJECT-18K11014
  • [Presentation] Essential structure of orexin 1 receptor antagonist YNT-7072019

    • Author(s)
      2.Ohrui S, Yamamoto N, Okada T, Yata M, Saitoh T, Kutsumura N, Nagumo N, Irukayama-Tomobe Y, Ishikawa Y, Ogawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H.
    • Organizer
      27th International Society of HeterocyclicChemistry Congress ROHM Theatre Kyoto & Miyakomesse
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K11014
  • [Presentation] 光ケージドadenosine 2A受容体ポジティブアロステリックモジュレーターの開発2018

    • Author(s)
      井岡秀二、斉藤毅、千歳洋平、Mustafa Korkutata、安部学、Michael Lazarus、長瀬博
    • Organizer
      日本ケミカルバイオロジー学会第13回年会
    • Data Source
      KAKENHI-PROJECT-18K14352
  • [Presentation] Non-peptidic Orexin receptor type-2 agonist attenuates body weight gain of high-fat fed mice2018

    • Author(s)
      1.Eriya Takahashi*, Kyoko Enomoto, Takuto Yamaguchi, Yasuhiro Ogawa, Shoji Fukusumi, Akari Kawai, Masaya Araki, Tsuyoshi Saitoh, Yoshimi Nakagawa, Yoko Irukayama-Tomobe, Hitoshi Shimano, Hiroshi Nagase, Masashi Yanagisawa
    • Organizer
      The 41st Annual Meeting of the Japan Neuroscience Society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K11014
  • [Presentation] 1,3,5-Trioxazatriquinane骨格を有するトリマーの合成とオレキシン受容体拮抗活性評価2018

    • Author(s)
      雨澤真櫻、堀内惇平、斉藤 毅、大下隆一郎、小川靖裕、石川有紀子、入鹿山容子、長谷川恵美、南雲康行、山本直司、沓村憲樹、早川大地、渡邉友里江、合田浩明、櫻井 武、柳沢正史、長瀬 博
    • Organizer
      第62回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] 睡眠覚醒を標的とする創薬研究2017

    • Author(s)
      斉藤毅
    • Organizer
      第4回次世代の有機化学・広島シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K16557
  • [Presentation] 低分子量オレキシン受容体2型作動薬YNT-185の組織学的、及び電気生理学的解析2017

    • Author(s)
      小川 靖裕、入鹿山 容子、富永 拡、細川 直人、斉藤 毅、長瀬 博、柳沢 正史
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎新聞文化ホール(長崎県長崎市)
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] オレキシン1受容体拮抗薬YNT-707の必須構造部位検討2017

    • Author(s)
      大類彩、山本直司、岡田卓大、谷田誠浩、斉藤毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、渡邊友里恵、早川大地、合田浩明、柳沢正史、長瀬博
    • Organizer
      第61回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-15K16557
  • [Presentation] モルヒナン骨格を有するオレキシン1受容体(OX1R)の特異的拮抗薬の設計・合成とOX1R結合の活性立体配座2017

    • Author(s)
      山本直司、大類彩、岡田卓大、谷田誠浩、斉藤毅、沓村憲樹、南雲康行、入鹿山容子、小川靖裕、石川有紀子、平山重人、渡辺友里恵、早川大地、合田浩明、柳沢正史、長瀬博
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-15K16557
  • [Presentation] 低分子量オレキシン受容体2型作動薬YNT-185の組織学的、及び電気生理学的解析2017

    • Author(s)
      小川靖裕、入鹿山容子、富永拡、細川直人、斉藤毅、長瀬博、柳沢正史
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎新聞文化ホール(長崎県長崎市)
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-15K16557
  • [Presentation] キャップトリマー骨格を有するオレキシン受容体拮抗薬の設計・合成12017

    • Author(s)
      堀内惇平、大下隆一郎、南雲康行、山本直司、沓村憲樹、斉藤毅、入鹿山容子、石川有紀子、小川靖裕、柳沢正史、長瀬博
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] 睡眠覚醒を標的とする創薬研究2017

    • Author(s)
      斉藤毅
    • Organizer
      第4回次世代の有機化学・広島シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] 大学における創薬研究とクロマトグラフィー2017

    • Author(s)
      斉藤毅
    • Organizer
      分取クロマトセミナー2017
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K16557
  • [Presentation] オレキシン1受容体拮抗薬YNT-707の必須構造部位検討2017

    • Author(s)
      大類彩、山本直司、岡田卓大、谷田誠浩、斉藤毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、渡邊友里恵、早川大地、合田浩明、柳沢正史、長瀬博
    • Organizer
      第61回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] 新規低分子量オレキシン受容体作動薬YNT-185の全身炎症後の活動回復作用の検討2017

    • Author(s)
      内田俊太郎、入鹿山容子、小川靖裕、富永拡、石川ゆい、木山麻衣子、斉藤毅、長瀬博、柳沢正史
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎新聞文化ホール(長崎県長崎市)
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-15K16557
  • [Presentation] キャップトリマー骨格を有するオレキシン受容体拮抗薬の設計・合成22017

    • Author(s)
      大下隆一郎、堀内惇平、南雲康行、山本直司、沓村憲樹、斉藤毅、入鹿山容子、石川有紀子、小川靖裕、柳沢正史、長瀬博
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] Design and synthesis of orexin 1 receptor selective antagonists2017

    • Author(s)
      Sayaka Ohrui, Naoshi Yamamoto, Masahiro Yata, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Shigeto Hirayama, Masashi Yanagisawa, Hiroshi Nagase
    • Organizer
      Tsukuba Global Science Week (TGSW) 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K16557
  • [Presentation] モルヒナン骨格を有するオレキシン1受容体(OX1R)の特異的拮抗薬の設計・合成とOX1R結合の活性立体配座2017

    • Author(s)
      山本直司、大類彩、岡田卓大、谷田誠浩、斉藤毅、沓村憲樹、南雲康行、入鹿山容子、小川靖裕、石川有紀子、平山重人、渡辺友里恵、早川大地、合田浩明、柳沢正史、長瀬博
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] Design and synthesis of orexin 1 receptor selective antagonists2017

    • Author(s)
      Sayaka Ohrui, Naoshi Yamamoto, Masahiro Yata, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Shigeto Hirayama, Masashi Yanagisawa, Hiroshi Nagase
    • Organizer
      Tsukuba Global Science Week (TGSW) 2017
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] 新規低分子量オレキシン受容体作動薬YNT-185の全身炎症後の活動回復作用の検討2017

    • Author(s)
      内田 俊太郎、入鹿山 容子、小川 靖裕、富永 拡、石川 ゆい、木山 麻衣子、斉藤 毅、長瀬 博、柳沢 正史
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎新聞文化ホール(長崎県長崎市)
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] オレキシン 2 受容体作動薬 YNT-185 の創製2016

    • Author(s)
      斉藤毅、永原崇志、沓村憲樹、中嶋龍、細川直人、入鹿山容子、小川靖裕、富永拡、黒田大介、合田浩明、藤井秀明、柳沢正史、長瀬博
    • Organizer
      第34回メディシナルケミストリーシンポジウム サテライトセッション
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-11-30
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K16557
  • [Presentation] 低分子オレキシン受容体アゴニストの創製2016

    • Author(s)
      斉藤 毅、永原崇志、沓村憲樹、入鹿山容子、小川靖裕、富永 拡、黒田大介、合田浩明、藤井秀明、柳沢正史、長瀬 博
    • Organizer
      第60回日本薬学会関東支部大会
    • Place of Presentation
      東京大学本郷キャンパス(東京都文京区)
    • Year and Date
      2016-09-17
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] Synthesis of Novel, Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton2016

    • Author(s)
      Naoshi Yamamoto, Masahiro Yata, Sayaka Ohrui, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Daisuke Kuroda, Hiroaki Gouda, Masashi Yanagisawa, Hiroshi Nagase
    • Organizer
      The 25th French-Japanese Symposium on Medicinal and Fine Chemistry
    • Place of Presentation
      Keio Plaza Hotel Tama(東京都多摩市)
    • Year and Date
      2016-05-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] モルヒナン骨格を有する新規オレキシン1受容体選択的拮抗薬の設計・合成①2016

    • Author(s)
      大類 彩、山本直司、谷田誠浩、岡田卓大、斉藤 毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、柳沢正史、長瀬 博
    • Organizer
      第60回日本薬学会関東支部大会
    • Place of Presentation
      東京大学本郷キャンパス(東京都文京区)
    • Year and Date
      2016-09-17
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] ナルフラフィンの構造を基にしたオレキシン1受容体選択的拮抗薬の設計・合成およびその薬理作用2016

    • Author(s)
      山本直司、谷田誠浩、大類 彩、岡田卓大、斉藤 毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、平山重人、柳沢正史、長瀬 博
    • Organizer
      第36回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2016-06-19
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] YNT-707のOX1Rアンタゴニスト活性発現のための必須構造の検討2016

    • Author(s)
      関 知範、中嶋 龍、斉藤 毅、入鹿山容子、小川靖裕、石川有紀子、柳沢正史、長瀬 博
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-12-01
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] モルヒナン骨格を有する新規オレキシン1受容体選択的拮抗薬の設計・合成②2016

    • Author(s)
      岡田卓大、山本直司、谷田誠浩、大類 彩、斉藤 毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、平山重人、柳沢正史、長瀬 博
    • Organizer
      第60回日本薬学会関東支部大会
    • Place of Presentation
      東京大学本郷キャンパス(東京都文京区)
    • Year and Date
      2016-09-17
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] オレキシン2受容体作動薬の設計・合成2016

    • Author(s)
      長瀬 博、永原 崇志、斉藤 毅、沓村 憲樹、入鹿山 容子、小川 靖裕、黒田 大祐、合田 浩明、藤井 秀明、柳沢 正史
    • Organizer
      第36回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2016-08-19
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] YNT-707のOX1R拮抗作用発現のための必須構造の検討2016

    • Author(s)
      関 知範、中嶋 龍、斉藤 毅、入鹿山容子、小川靖裕、石川有紀子、柳沢正史、長瀬 博
    • Organizer
      第60回日本薬学会関東支部大会
    • Place of Presentation
      東京大学本郷キャンパス(東京都文京区)
    • Year and Date
      2016-09-17
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] オレキシン2受容体作動薬の設計・合成2016

    • Author(s)
      長瀬博、永原崇志、斉藤毅、沓村憲樹、入鹿山容子、小川靖裕、黒田大祐、合田浩明、藤井秀明、柳沢正史
    • Organizer
      第36回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2016-08-19
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K16557
  • [Presentation] Development of non-peptide orexin receptor agonists for controlling sleep/wake cycle2016

    • Author(s)
      Tsuyoshi Saitoh, Takashi Nagahara, Noriki Kutsumura, Yoko Irukayama, Yasuhiro Ogawa, Daisuke Kuroda, Hiroaki Gouda, Hideaki Fujii, Masashi Yanagisawa, Hiroshi Nagase
    • Organizer
      日本化学会第96春季年会
    • Place of Presentation
      同志社大学京田辺キャンパス、京都府、京都市
    • Year and Date
      2016-03-27
    • Data Source
      KAKENHI-PROJECT-15K16557
  • [Presentation] 低分子オレキシン受容体アゴニストの創製2016

    • Author(s)
      斉藤毅、永原崇志、沓村憲樹、入鹿山容子、小川靖裕、富永拡、黒田大介、合田浩明、藤井秀明、柳沢正史、長瀬博
    • Organizer
      第60回日本薬学会関東支部大会
    • Place of Presentation
      東京大学本郷キャンパス(東京都文京区)
    • Year and Date
      2016-09-17
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K16557
  • [Presentation] オレキシン2受容体作動薬YNT-185の創製2016

    • Author(s)
      斉藤 毅、永原崇志、沓村憲樹、中嶋 龍、細川直人、入鹿山容子、小川靖裕、富永 拡、黒田大介、合田浩明、藤井秀明、柳沢正史、長瀬 博
    • Organizer
      第34回メディシナルケミストリーシンポジウム サテライトセッション
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-11-30
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] モルヒナン骨格を有するオレキシン1受容体選択的拮抗薬の設計・合成とその薬理作用”2016

    • Author(s)
      大類 彩、山本直司、谷田誠浩、岡田卓大、斉藤 毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、平山重人、柳沢正史、長瀬 博
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] 低分子オレキシン受容体アゴニストの創製2015

    • Author(s)
      斉藤毅、永原崇志、沓村憲樹、入鹿山容子、小川靖裕、黒田大祐、合田浩明、藤井秀明、柳沢正史、長瀬博
    • Organizer
      第33回 メディシナルケミストリーシンポジウム
    • Place of Presentation
      幕張国際研修センター、千葉県、千葉市
    • Year and Date
      2015-11-26
    • Data Source
      KAKENHI-PROJECT-15K16557
  • [Presentation] Discovery of novel orexin receptor agonists for controlling sleep/awake cycle2015

    • Author(s)
      T. Saitoh, T. Nagahara, N. Kutsumura, Y. Irukayama, Y. Ogawa, H. Fujii, M. Yanagisawa, H. Nagase
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      ヒルトンハワイアンビレッジ、ホノルル、アメリカ
    • Year and Date
      2015-12-19
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K16557
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