SAITOH Tsuyoshi 斉藤毅

… Alternative Names

Researcher Number	80609933
Other IDs	https://orcid.org/0000-0001-6105-6292
Affiliation (Current)	2019: 筑波大学, 国際統合睡眠医科学研究機構, 助教
Affiliation (based on the past Project Information) *help	2015 – 2019: 筑波大学, 国際統合睡眠医科学研究機構, 助教 2013: 慶應義塾大学, 理工学部, 助教 2012: 筑波大学, 学内共同利用施設等, 助教 2011: 慶應義塾大学, 理工学部, 助教
Review Section/Research Field	Principal Investigator Chemical biology / Basic Section 37030:Chemical biology-related Except Principal Investigator Chemical biology / Drug development chemistry / Basic / Social brain science / General medical chemistry / Basic Section 48040:Medical biochemistry-related / Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator オレキシン / 睡眠覚醒 / 作動薬 / ケージド化合物 / 光ケージド化合物 / 睡眠 / 覚醒 / スイッチング化合物 / ケミカルバイオロジー / 神経科学 / 脳・神経 / 有機合成化学 / 光反応 … More Except Principal Investigator … More

バイアスリガンド開発に資するG蛋白質/アレスチン-GPCR複合体の構造解析Ongoing
- Principal Investigator
  
  寿野良二
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kansai Medical University
オレキシン２型受容体作動薬による代謝リズム調節機構の解明Ongoing
- Principal Investigator
  
  福住昌司
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  University of Tsukuba
光により覚醒を制御する分子ツールの開発Principal InvestigatorOngoing
- Principal Investigator
  
  斉藤毅
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  University of Tsukuba
The role of the nucleus accumbens in regulating slow-wave sleep by motivated behaviorOngoing
- Principal Investigator
  
  ラザルスミハエル
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic / Social brain science
- Research Institution
  University of Tsukuba
新規オレキシンリガンドの創出と薬理作用の解明Ongoing
- Principal Investigator
  
  長瀬博
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  University of Tsukuba
Development of novel molecular tool for controlling sleep/wake cycle and feeding behaviorPrincipal Investigator
- Principal Investigator
  
  SAITOH Tsuyoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical biology
- Research Institution
  University of Tsukuba
Differential analysis of the crystal structures of active / inactive orexin receptor contributing to rational development of sleep control drug
- Principal Investigator
  
  Suno Ryoji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
Bio-imaging of peritoneal metastasis and molecular design of inhibitors
- Principal Investigator
  
  UMEZAWA Kazuo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical biology
- Research Institution
  Aichi Medical University
  Keio University

All 2019 2018 2017 2016 2015 2012 2011

All Journal Article Presentation

[Journal Article] Enhancing endogenous adenosine A2A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function2019
- Author(s)
  Korkutata M, Saitoh T, Cherasse Y, Ioka S, Duo F, Qin R, Murakoshi N, Fujii S, Zhou X, Sugiyama F, Chen JF, Kumagai H, Nagase H, Lazarus M
- Journal Title
  
  Neuropharmacology
  
  Volume: 144 Pages: 122-132
- DOI
  10.1016/j.neuropharm.2018.10.022
- NAID
  120006583051
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PUBLICLY-18H04966, KAKENHI-PROJECT-17H02215
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring2019
- Author(s)
  Yamamoto Naoshi、Ohrui Sayaka、Okada Takahiro、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Pages: 1747-1758
- DOI
  10.1016/j.bmc.2019.03.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14352, KAKENHI-PROJECT-17H06095
[Journal Article] Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats2018
- Author(s)
  Toyama, S., Shimoyama N, Tagaito Y., Nagase H., Saitoh T., Yanagisawa M., and Shimoyama, M.
- Journal Title
  
  Anesthesiology: The Journal of the American Society of Anesthesiologists
  
  Volume: 128 Pages: 992-1003
- DOI
  10.1097/aln.0000000000002161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10985, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-15K16557
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity2018
- Author(s)
  Ohrui Sayaka、Yamamoto Naoshi、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorganic & medicinal chemistry letters
  
  Volume: 28 Pages: 774-777
- DOI
  10.1016/j.bmcl.2017.12.069
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-15K16557
[Journal Article] オレキシン研究の進展と新規受容体作動薬の創製2018
- Author(s)
  斉藤毅，長瀬博
- Journal Title
  
  バイオサイエンスとインダストリー(B&I)
  
  Volume: 76 Pages: 127-29
- Data Source
  KAKENHI-PROJECT-15K16557
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor2017
- Author(s)
  Yamamoto Naoshi、Ohrui Sayaka、Okada Takahiro、Yata Masahiro、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorganic & medicinal chemistry letters
  
  Volume: 27 Pages: 4176-4179
- DOI
  10.1016/j.bmcl.2017.07.011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-15K16557
[Journal Article] Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and their Pharmacologies2017
- Author(s)
  Nagase H and Yanagisawa M et al.
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 60 Pages: 1018-1040
- DOI
  10.1021/acs.jmedchem.6b01418
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-15H05935, KAKENHI-PROJECT-26220207, KAKENHI-PROJECT-16H05098, KAKENHI-PROJECT-15H06606
[Journal Article] Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models2017
- Author(s)
  Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 114 Pages: 5731-5736
- DOI
  10.1073/pnas.1700499114
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-16H06400, KAKENHI-PROJECT-15H03122, KAKENHI-PROJECT-15K16557
[Journal Article] IIIS発　ナルコレプシー治療薬開発に向けた取り組み2017
- Author(s)
  斉藤毅，入鹿山容子，柳沢正史，長瀬博
- Journal Title
  
  なるこ
  
  Volume: 34 Pages: 8-10
- Data Source
  KAKENHI-PROJECT-15K16557
[Journal Article] 睡眠覚醒を制御する世界初の分子：オレキシン２受容体作動薬YNT-185の創製2016
- Author(s)
  斉藤　毅，長瀬　博
- Journal Title
  
  和光純薬時報
  
  Volume: 84 Pages: 2-5
- Data Source
  KAKENHI-PROJECT-16H05098
[Journal Article] 低分子オレキシン受容体アゴニストの創製2016
- Author(s)
  斉藤　毅，長瀬　博
- Journal Title
  
  MEDCHEM NEWS
  
  Volume: 26 Pages: 90-96
- NAID
  130007383316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05098
[Journal Article] 低分子オレキシン受容体アゴニストの創製2016
- Author(s)
  斉藤毅、長瀬博
- Journal Title
  
  MEDCHEM NEWS
  
  Volume: 26 Pages: 90-96
- NAID
  130007383316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K16557
[Journal Article] Design and synthesis of non-peptide, selective orexin receptor 2 agonists2015
- Author(s)
  Nagahara T, Saitoh T, Kutsumura N, Irukayama-Tomobe Y, Ogawa Y, Kuroda D, Gouda H, Kumagai H, Fujii H, Yanagisawa M, Nagase H
- Journal Title
  
  J Med Chem.
  
  Volume: 58 Pages: 7931-37
- DOI
  10.1021/acs.jmedchem.5b00988
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-15K16557, KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-26220207
[Journal Article] Conophylline suppresses pancreatic stellate cells and improves islet fibrosis in Goto-Kakizaki rats2012
- Author(s)
  R.Saito, K.Umezawa, et al
- Journal Title
  
  Endocrinology
  
  Volume: 153 Pages: 621-630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Design and synthesis of biotinylated DHMEQ for direct identification of its target NF-κB components., 20112011
- Author(s)
  T.Saitoh, K.Umezawa, et al
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 21 Pages: 6293-6296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] Development of photocaged adenosine 2A receptor activator2019
- Author(s)
  Tsuyoshi Saitoh, Shuji Ioka, Mustafa Korkutata, Yohei Chitose, Manabu Abe, Michael Lazarus, Hiroshi Nagase
- Organizer
  13th International Symposium on Organic Reactions (ISOR-13)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14352
[Presentation] Non-peptidic Orexin receptor type-2 agonist attenuates body weight gain of high-fat fed mice2018
- Author(s)
  1.Eriya Takahashi*, Kyoko Enomoto, Takuto Yamaguchi, Yasuhiro Ogawa, Shoji Fukusumi, Akari Kawai, Masaya Araki, Tsuyoshi Saitoh, Yoshimi Nakagawa, Yoko Irukayama-Tomobe, Hitoshi Shimano, Hiroshi Nagase, Masashi Yanagisawa
- Organizer
  The 41st Annual Meeting of the Japan Neuroscience Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11014
[Presentation] 光ケージドadenosine 2A受容体ポジティブアロステリックモジュレーターの開発2018
- Author(s)
  井岡秀二、斉藤毅、千歳洋平、Mustafa Korkutata、安部学、Michael Lazarus、長瀬博
- Organizer
  日本ケミカルバイオロジー学会第13回年会
- Data Source
  KAKENHI-PROJECT-18K14352
[Presentation] オレキシン１受容体拮抗薬YNT-707の必須構造部位検討2017
- Author(s)
  大類彩、山本直司、岡田卓大、谷田誠浩、斉藤毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、渡邊友里恵、早川大地、合田浩明、柳沢正史、長瀬博
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] Design and synthesis of orexin 1 receptor selective antagonists2017
- Author(s)
  Sayaka Ohrui, Naoshi Yamamoto, Masahiro Yata, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Shigeto Hirayama, Masashi Yanagisawa, Hiroshi Nagase
- Organizer
  Tsukuba Global Science Week (TGSW) 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] 睡眠覚醒を標的とする創薬研究2017
- Author(s)
  斉藤毅
- Organizer
  第４回次世代の有機化学・広島シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] 新規低分子量オレキシン受容体作動薬YNT-185の全身炎症後の活動回復作用の検討2017
- Author(s)
  内田　俊太郎、入鹿山　容子、小川　靖裕、富永　拡、石川　ゆい、木山　麻衣子、斉藤　毅、長瀬　博、柳沢　正史
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎新聞文化ホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] 大学における創薬研究とクロマトグラフィー2017
- Author(s)
  斉藤毅
- Organizer
  分取クロマトセミナー2017
- Invited
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] モルヒナン骨格を有するオレキシン1受容体（OX1R）の特異的拮抗薬の設計・合成とOX1R結合の活性立体配座2017
- Author(s)
  山本直司、大類彩、岡田卓大、谷田誠浩、斉藤毅、沓村憲樹、南雲康行、入鹿山容子、小川靖裕、石川有紀子、平山重人、渡辺友里恵、早川大地、合田浩明、柳沢正史、長瀬博
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] 低分子量オレキシン受容体2型作動薬YNT-185の組織学的、及び電気生理学的解析2017
- Author(s)
  小川　靖裕、入鹿山　容子、富永　拡、細川　直人、斉藤　毅、長瀬　博、柳沢　正史
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎新聞文化ホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] YNT-707のOX1Rアンタゴニスト活性発現のための必須構造の検討2016
- Author(s)
  関　知範、中嶋　龍、斉藤　毅、入鹿山容子、小川靖裕、石川有紀子、柳沢正史、長瀬　博
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] 低分子オレキシン受容体アゴニストの創製2016
- Author(s)
  斉藤　毅、永原崇志、沓村憲樹、入鹿山容子、小川靖裕、富永　拡、黒田大介、合田浩明、藤井秀明、柳沢正史、長瀬　博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Invited
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] モルヒナン骨格を有する新規オレキシン1受容体選択的拮抗薬の設計・合成②2016
- Author(s)
  岡田卓大、山本直司、谷田誠浩、大類　彩、斉藤　毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、平山重人、柳沢正史、長瀬　博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Synthesis of Novel, Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton2016
- Author(s)
  Naoshi Yamamoto, Masahiro Yata, Sayaka Ohrui, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Daisuke Kuroda, Hiroaki Gouda, Masashi Yanagisawa, Hiroshi Nagase
- Organizer
  The 25th French-Japanese Symposium on Medicinal and Fine Chemistry
- Place of Presentation
  Keio Plaza Hotel Tama（東京都多摩市）
- Year and Date
  2016-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] オレキシン2受容体作動薬の設計・合成2016
- Author(s)
  長瀬　博、永原　崇志、斉藤　毅、沓村　憲樹、入鹿山　容子、小川　靖裕、黒田　大祐、合田　浩明、藤井　秀明、柳沢　正史
- Organizer
  第36回鎮痛薬・オピオイドペプチドシンポジウム
- Place of Presentation
  北海道大学（北海道札幌市）
- Year and Date
  2016-08-19
- Invited
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] モルヒナン骨格を有する新規オレキシン1受容体選択的拮抗薬の設計・合成①2016
- Author(s)
  大類　彩、山本直司、谷田誠浩、岡田卓大、斉藤　毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、柳沢正史、長瀬　博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] オレキシン２受容体作動薬YNT-185の創製2016
- Author(s)
  斉藤　毅、永原崇志、沓村憲樹、中嶋　龍、細川直人、入鹿山容子、小川靖裕、富永　拡、黒田大介、合田浩明、藤井秀明、柳沢正史、長瀬　博
- Organizer
  第34回メディシナルケミストリーシンポジウム　サテライトセッション
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] ナルフラフィンの構造を基にしたオレキシン1受容体選択的拮抗薬の設計・合成およびその薬理作用2016
- Author(s)
  山本直司、谷田誠浩、大類　彩、岡田卓大、斉藤　毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、平山重人、柳沢正史、長瀬　博
- Organizer
  第36回鎮痛薬・オピオイドペプチドシンポジウム
- Place of Presentation
  北海道大学（北海道札幌市）
- Year and Date
  2016-06-19
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] YNT-707のOX1R拮抗作用発現のための必須構造の検討2016
- Author(s)
  関　知範、中嶋　龍、斉藤　毅、入鹿山容子、小川靖裕、石川有紀子、柳沢正史、長瀬　博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] モルヒナン骨格を有するオレキシン１受容体選択的拮抗薬の設計・合成とその薬理作用”2016
- Author(s)
  大類　彩、山本直司、谷田誠浩、岡田卓大、斉藤　毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、平山重人、柳沢正史、長瀬　博
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Development of non-peptide orexin receptor agonists for controlling sleep/wake cycle2016
- Author(s)
  Tsuyoshi Saitoh, Takashi Nagahara, Noriki Kutsumura, Yoko Irukayama, Yasuhiro Ogawa, Daisuke Kuroda, Hiroaki Gouda, Hideaki Fujii, Masashi Yanagisawa, Hiroshi Nagase
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  同志社大学京田辺キャンパス、京都府、京都市
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] 低分子オレキシン受容体アゴニストの創製2015
- Author(s)
  斉藤毅、永原崇志、沓村憲樹、入鹿山容子、小川靖裕、黒田大祐、合田浩明、藤井秀明、柳沢正史、長瀬博
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研修センター、千葉県、千葉市
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] Discovery of novel orexin receptor agonists for controlling sleep/awake cycle2015
- Author(s)
  T. Saitoh, T. Nagahara, N. Kutsumura, Y. Irukayama, Y. Ogawa, H. Fujii, M. Yanagisawa, H. Nagase
- Organizer
  Pacifichem 2015
- Place of Presentation
  ヒルトンハワイアンビレッジ、ホノルル、アメリカ
- Year and Date
  2015-12-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16557

1. Yanagisawa Masashi (20202369)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
2. Suno Ryoji (60447521)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 入鹿山容子 (90312834)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
4. UMEZAWA Kazuo (70114402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SIMIZU Siro (30312268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ISHIKAWA Yuichi (40348826)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OZAKI Michitaka (80256510)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HAGA Sanae (60706505)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KOBAYASHI Takuya (20311730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 長瀬博 (70383651)

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
11. 桜井武 (60251055)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. ラザルスミハエル (80469650)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 高田陽子 (60435740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 大石陽 (70554004)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 野村紀通 (10314246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 福住昌司 (10750002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 櫻井勝康 (70507920)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. Kobilka Brian K

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 黒田大祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 下山恵美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 熊谷英敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 梅沢一夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

SAITOH Tsuyoshi 斉藤 毅

Saitoh Tsuyoshi 斎藤 毅

SAITO Tsuyoshi 斉藤 毅

Research Projects

Research Products

Co-Researchers

バイアスリガンド開発に資するG蛋白質/アレスチン-GPCR複合体の構造解析Ongoing

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オレキシン２型受容体作動薬による代謝リズム調節機構の解明Ongoing

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光により覚醒を制御する分子ツールの開発Principal InvestigatorOngoing

Principal Investigator

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The role of the nucleus accumbens in regulating slow-wave sleep by motivated behaviorOngoing

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新規オレキシンリガンドの創出と薬理作用の解明Ongoing

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Development of novel molecular tool for controlling sleep/wake cycle and feeding behaviorPrincipal Investigator

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Differential analysis of the crystal structures of active / inactive orexin receptor contributing to rational development of sleep control drug

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Bio-imaging of peritoneal metastasis and molecular design of inhibitors

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[Journal Article] Enhancing endogenous adenosine A2A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] オレキシン研究の進展と新規受容体作動薬の創製2018

Author(s)

Journal Title

Data Source

[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor2017

SAITOH Tsuyoshi 斉藤毅

Saitoh Tsuyoshi 斎藤毅

SAITO Tsuyoshi 斉藤毅

[Journal Article] IIIS発　ナルコレプシー治療薬開発に向けた取り組み2017