SAITOH Tsuyoshi 斉藤毅

… Alternative Names

Saitoh Tsuyoshi 斎藤毅

SAITO Tsuyoshi 斉藤毅

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Researcher Number	80609933
Other IDs	https://orcid.org/0000-0001-6105-6292
Affiliation (Current)	2025: 筑波大学, 国際統合睡眠医科学研究機構, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2025: 筑波大学, 国際統合睡眠医科学研究機構, 准教授 2015 – 2022: 筑波大学, 国際統合睡眠医科学研究機構, 助教 2013: 慶應義塾大学, 理工学部, 助教 2012: 筑波大学, 学内共同利用施設等, 助教 2011: 慶應義塾大学, 理工学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 37030:Chemical biology-related / Transformative Research Areas, Section (II) / Chemical biology Except Principal Investigator Basic Section 48040:Medical biochemistry-related / Basic Section 53010:Gastroenterology-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Biological Sciences / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Basic Section 59040:Nutrition science and health science-related / General medical chemistry / Basic / Social brain science / Drug development chemistry / Chemical biology
Keywords	Principal Investigator 作動薬 / オレキシン / オピオイド受容体 / 拮抗薬 / 神経科学 / 創薬化学 / GPCR / シグナル伝達 / Gタンパク質共役型受容体 / 分子設計 … More / オレキシン1受容体 / 脳・神経 / ケージド化合物 / 睡眠覚醒 / OX1R / 構造生物学 / オピオイド / 神経回路 / クライオ電子顕微鏡単粒子解析 / 薬理学 / δオピオイド受容体 / κオピオイド受容体 / PETプローブ / オレキシン受容体 / フルオロアルキル / 有機化学 / 合成化学 / スイッチング化合物 / 覚醒 / 睡眠 / 光ケージド化合物 / 有機合成化学 / ケミカルバイオロジー / 光反応 / 光ケージド薬物 … More Except Principal Investigator GPCR / 睡眠 / 膜タンパク質 / シグナル伝達 / ナルコレプシー / オレキシン / SBDD / クライオ電子顕微鏡単粒子解析 / 創薬 / 薬剤開発 / X線結晶構造解析 / オレキシン受容体 / 創薬化学 / 作動薬 / オルガノイドモデル / 腸脳相関 / プロドラッグ / 低代謝 / 低体温 / Qニューロン / オロト酸 / 創薬科学 / 脳機能 / 神経生物学 / 機能解明 / 薬理評価 / オレキシン１受容体 / アゴニスト / 分子設計 / オレキシン1受容体 / バイアスリガンド / クライオ電子顕微鏡 / バイアスドリガンド / オレキシン受容体作動薬 / 機能性抗体 / 抗体 / ヒト膜受容体 / Nucleus Accumbens / Motivation / Sleep / Nucleus accumbens / nucleus accumbens / motivation / sleep / 覚醒 / ナルフラフィン / 有機合成化学 / OX2R作動薬 / OX1R拮抗薬 / モルフィナン骨格 / OX1R作動薬 / 拮抗薬 / モルヒナン / オピオイド / 光プローブ / 標的タンパク質 / 探索プローブ / NF-κB / 卵巣癌 / メラノーマ / アノイキス / 転移 / 卵巣がん / pyrapaxilline / Exo-ene EQ / migracin / DTCM-glutarimide / DHMEQ / NF-kappa B / 遊走 / 浸潤 / 腹腔内転移 / バイオイメージング / 分子デザイン Less

末梢オレキシン腸脳相関における炎症性消化管疾患病態解明
- Principal Investigator
  
  土屋輝一郎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  University of Tsukuba
睡眠覚醒を制御するオレキシン受容体シグナル伝達機構の全貌解明と選択的薬剤開発
- Principal Investigator
  
  寿野良二
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kansai Medical University
持久力を高める次世代栄養戦略
- Principal Investigator
  
  征矢英昭
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  University of Tsukuba
Development of novel chemical tools targeting orexin 1 receptorsPrincipal Investigator
- Principal Investigator
  
  斉藤毅
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  University of Tsukuba
Deciphering the mysteries of sleep:creating a global network of sleep neurobiologists
- Principal Investigator
  
  柳沢正史
- Project Period (FY)
  2022 – 2028
- Research Category
  
  Fund for the Promotion of Joint International Research (International Leading Research )
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
Construction of morphinan-based focused libraryPrincipal Investigator
- Principal Investigator
  
  Saitoh Tsuyoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  University of Tsukuba
Multi-scale platform for untangling physiological complexityArea Organizer
- Area Organizer
  
  斉藤毅
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
Multi-scale platform for untangling physiological complexityPrincipal Investigator
- Principal Investigator
  
  Saitoh Tsuyoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  University of Tsukuba
Development of novel PET probes targeting orexin 1 receptorPrincipal Investigator
- Principal Investigator
  
  Saitoh Tsuyoshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  University of Tsukuba
Development of novel selective orexin 1 receptor agonists and elucidation of the function of orexin receptors
- Principal Investigator
  
  Nagase Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  University of Tsukuba
Structural analysis of G protein/Arrestin-GPCR complex for development of biased ligands
- Principal Investigator
  
  SUNO Ryoji
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kansai Medical University
Elucidation of metabolic rhythm regulation by orexin agonist
- Principal Investigator
  
  Fukusumi Shoji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  University of Tsukuba
Development of novel photochemical tools to regulate wakefulnessPrincipal Investigator
- Principal Investigator
  
  Tsuyoshi Saitoh
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  University of Tsukuba
The role of the nucleus accumbens in regulating slow-wave sleep by motivated behavior
- Principal Investigator
  
  Lazarus Michael
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic / Social brain science
- Research Institution
  University of Tsukuba
Development of novel orexin ligand and its pharmacological activity
- Principal Investigator
  
  Nagase Hiroshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  University of Tsukuba
Differential analysis of the crystal structures of active / inactive orexin receptor contributing to rational development of sleep control drug
- Principal Investigator
  
  Suno Ryoji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
Development of novel molecular tool for controlling sleep/wake cycle and feeding behaviorPrincipal Investigator
- Principal Investigator
  
  SAITOH Tsuyoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical biology
- Research Institution
  University of Tsukuba
Bio-imaging of peritoneal metastasis and molecular design of inhibitors
- Principal Investigator
  
  UMEZAWA Kazuo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical biology
- Research Institution
  Aichi Medical University
  Keio University

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All Journal Article Presentation Patent

[Journal Article] Morphinan Evolution: The Impact of Advances in Biochemistry and Molecular Biology2024
- Author(s)
  Kajino Keita、Tokuda Akihisa、Saitoh Tsuyoshi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 175 Issue: 4 Pages: 337-355
- DOI
  10.1093/jb/mvae021
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-21H05111
[Journal Article] Design and synthesis of unique morphinan-type molecules: Their application to the search for the unexplored binding domain between opioid receptors and morphinan ligands2024
- Author(s)
  Maeda Kenta、Sugai Tomoya、Tokuda Akihisa、Kajino Keita、Saitoh Tsuyoshi、Nagase Hiroshi、Kutsumura Noriki
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 99 Pages: 129611-129611
- DOI
  10.1016/j.bmcl.2024.129611
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-21H05111
[Journal Article] The present and future of synthetic orexin receptor agonists2023
- Author(s)
  Saitoh Tsuyoshi、Sakurai Takeshi
- Journal Title
  
  Peptides
  
  Volume: 167 Pages: 171051-171051
- DOI
  10.1016/j.peptides.2023.171051
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-21H05111
[Journal Article] Chemogenetic activation of G12 signaling enhances adipose tissue browning2023
- Author(s)
  Ono Y, Ito R, Arai K, Singh G, Saitoh T, Russell RB, Raimondi F, Aoki J, Sakai J, Inoue A.
- Journal Title
  
  Signal Transduction and Targeted Therapy
  
  Volume: 8 Issue: 1 Pages: 307-307
- DOI
  10.1038/s41392-023-01524-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18411, KAKENHI-ORGANIZER-21H05111, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-21H04826
[Journal Article] Design and synthesis of novel orexin 2 receptor agonists with a 1,3,5-trioxazatriquinane skeleton2023
- Author(s)
  Mao Amezawa, Naoshi Yamamoto, Yasuyuki Nagumo, Noriki Kutsumura, Yukiko Ishikawa, Masashi Yanagisawa, Hiroshi Nagase, Tsuyoshi Saitoh
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 82 Pages: 129151-129151
- DOI
  10.1016/j.bmcl.2023.129151
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H04918, KAKENHI-ORGANIZER-21H05111, KAKENHI-PROJECT-20H03361
[Journal Article] Design and Synthesis of Orexin 1 Receptor-Selective Agonists2023
- Author(s)
  Keita Iio, Kao Hashimoto, Yasuyuki Nagumo, Mao Amezawa, Taisei Hasegawa, Naoshi Yamamoto, Noriki Kutsumura, Katsuhiko Takeuchi, Yukiko Ishikawa, Hikari Yamamoto, Akihisa Tokuda, Tetsu Sato, Yasuo Uchida, Asuka Inoue, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase, Tsuyoshi Saitoh
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 66 Issue: 8 Pages: 5453-5464
- DOI
  10.1021/acs.jmedchem.2c01773
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H04918, KAKENHI-ORGANIZER-21H05111, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-20H03361
[Journal Article] Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring2022
- Author(s)
  Keita Iio, Tsuyoshi Saitoh, Ryuichiro Ohshita, Tsubasa Hino, Mao Amezawa, Yoshiaki Takayama, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kustumura, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 60 Pages: 128555-128555
- DOI
  10.1016/j.bmcl.2022.128555
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-21H05111, KAKENHI-PROJECT-20H03361, KAKENHI-PROJECT-19K07314
[Journal Article] Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton2022
- Author(s)
  Tsubasa Hino, Tsuyoshi Saitoh, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 59 Pages: 128530-128530
- DOI
  10.1016/j.bmcl.2022.128530
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-21H05111, KAKENHI-PROJECT-20H03361, KAKENHI-PROJECT-19K07314
[Journal Article] Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) librasy2022
- Author(s)
  Saitoh T, Amezawa M, Horiuchi J, Nagumo Y, Yamamoto N, Kutsumura N, Ohshita R, Tokuda A, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Hasegawa E, Sakurai T, Uchida Y, Sato T, Gouda H, Tanimura R, Yanagisawa M, Nagase H.
- Journal Title
  
  Eur J Med Chem
  
  Volume: 240 Pages: 114505-27
- DOI
  10.1016/j.ejmech.2022.114505
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07314, KAKENHI-PROJECT-22H04918, KAKENHI-ORGANIZER-21H05111, KAKENHI-PROJECT-20H03361
[Journal Article] Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands2022
- Author(s)
  Iio Keita、Kutsumura Noriki、Nagumo Yasuyuki、Saitoh Tsuyoshi、Tokuda Akihisa、Hashimoto Kao、Yamamoto Naoshi、Kise Ryoji、Inoue Asuka、Mizoguchi Hirokazu、Nagase Hiroshi
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 56 Pages: 128485-128485
- DOI
  10.1016/j.bmcl.2021.128485
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05710, KAKENHI-PUBLICLY-20H04763, KAKENHI-ORGANIZER-21H05111, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-21K06602
[Journal Article] Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine2020
- Author(s)
  Nagumo Yasuyuki、Katoh Koki、Iio Keita、Saitoh Tsuyoshi、Kutsumura Noriki、Yamamoto Naoshi、Ishikawa Yukiko、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Baba Takeshi、Tanimura Ryuji、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 30 Issue: 17 Pages: 127360-127360
- DOI
  10.1016/j.bmcl.2020.127360
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05710, KAKENHI-PROJECT-19K07314, KAKENHI-PROJECT-18K11014, KAKENHI-ORGANIZER-15H05935, KAKENHI-WRAPUP-20H05615
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring2019
- Author(s)
  Yamamoto Naoshi、Ohrui Sayaka、Okada Takahiro、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Issue: 8 Pages: 1747-1758
- DOI
  10.1016/j.bmc.2019.03.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-18K11014, KAKENHI-PROJECT-19K07314, KAKENHI-PROJECT-18K14352, KAKENHI-PROJECT-16H05098
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity.2019
- Author(s)
  Saitoh T, Seki K, Nakajima R, Yamamoto N, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 29 Issue: 18 Pages: 2655-2658
- DOI
  10.1016/j.bmcl.2019.07.039
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07314, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-18K14352
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity.2019
- Author(s)
  Saitoh T, Seki K, Nakajima R, Yamamoto N, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 29 Issue: 3 Pages: 26552658-26552658
- DOI
  10.1016/j.bmcl.2019.126893
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11014, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-18K14352
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity2018
- Author(s)
  Ohrui Sayaka、Yamamoto Naoshi、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 28 Issue: 4 Pages: 774-777
- DOI
  10.1016/j.bmcl.2017.12.069
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-15K16557, KAKENHI-PROJECT-16H05098
[Journal Article] Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats2018
- Author(s)
  Toyama, S., Shimoyama N, Tagaito Y., Nagase H., Saitoh T., Yanagisawa M., and Shimoyama, M.
- Journal Title
  
  Anesthesiology
  
  Volume: 128 Issue: 5 Pages: 992
- DOI
  10.1097/aln.0000000000002161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10985, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-15K16557, KAKENHI-PROJECT-16H05098
[Journal Article] Enhancing endogenous adenosine A2A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function2018
- Author(s)
  Korkutata M, Saitoh T, Cherasse Y, Ioka S, Duo F, Qin R, Murakoshi N, Fujii S, Zhou X, Sugiyama F, Chen JF, Kumagai H, Nagase H, Lazarus M
- Journal Title
  
  Neuropharmacology
  
  Volume: 144 Pages: 122-132
- DOI
  10.1016/j.neuropharm.2018.10.022
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-INTERNATIONAL-15K21745, KAKENHI-PUBLICLY-18H04966, KAKENHI-PROJECT-17H02215, KAKENHI-PROJECT-16K18698, KAKENHI-ORGANIZER-15H05935
[Journal Article] Favorskii-Type Rearrangement of the 4,5-Epoxymorphinan Skeleton2018
- Author(s)
  Kutsumura Noriki、Koyama Yasuaki、Suzuki Yuko、Tominaga Ken-ichi、Yamamoto Naoshi、Saitoh Tsuyoshi、Nagumo Yasuyuki、Nagase Hiroshi
- Journal Title
  
  Organic Letters
  
  Volume: 20 Issue: 6 Pages: 1559-1562
- DOI
  10.1021/acs.orglett.8b00288
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13259, KAKENHI-PROJECT-16H05098
[Journal Article] オレキシン受容体を標的としたナルコレプシー治療薬の開発2018
- Author(s)
  斉藤毅、長瀬博
- Journal Title
  
  バイオサイエンスとインダストリー（B&I）
  
  Volume: 76 Pages: 127-129
- NAID
  40021512201
- Data Source
  KAKENHI-PROJECT-16H05098
[Journal Article] オレキシン研究の進展と新規受容体作動薬の創製2018
- Author(s)
  斉藤毅，長瀬博
- Journal Title
  
  バイオサイエンスとインダストリー(B&I)
  
  Volume: 76 Pages: 127-29
- Data Source
  KAKENHI-PROJECT-15K16557
[Journal Article] Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models2017
- Author(s)
  Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 114 Issue: 22 Pages: 5731-5736
- DOI
  10.1073/pnas.1700499114
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-16H06400, KAKENHI-PROJECT-15H03122, KAKENHI-PROJECT-15K16557, KAKENHI-PROJECT-16H05098
[Journal Article] IIIS発　ナルコレプシー治療薬開発に向けた取り組み2017
- Author(s)
  斉藤毅、入鹿山容子、柳沢正史、長瀬博
- Journal Title
  
  なるこ
  
  Volume: 34 Pages: 8-10
- Data Source
  KAKENHI-PROJECT-16H05098
[Journal Article] IIIS発　ナルコレプシー治療薬開発に向けた取り組み2017
- Author(s)
  斉藤毅，入鹿山容子，柳沢正史，長瀬博
- Journal Title
  
  なるこ
  
  Volume: 34 Pages: 8-10
- Data Source
  KAKENHI-PROJECT-15K16557
[Journal Article] The application of a specific morphinan template to the synthesis of galanthamine2017
- Author(s)
  Yamamoto Naoshi、Okada Takahiro、Harada Yukimasa、Kutsumura Noriki、Imaide Satomi、Saitoh Tsuyoshi、Fujii Hideaki、Nagase Hiroshi
- Journal Title
  
  Tetrahedron
  
  Volume: 73 Issue: 39 Pages: 5751-5758
- DOI
  10.1016/j.tet.2017.08.014
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05098
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor2017
- Author(s)
  Yamamoto Naoshi、Ohrui Sayaka、Okada Takahiro、Yata Masahiro、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 27 Issue: 17 Pages: 4176-4179
- DOI
  10.1016/j.bmcl.2017.07.011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-15K16557, KAKENHI-PROJECT-16H05098, KAKENHI-ORGANIZER-15H05935
[Journal Article] Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies2017
- Author(s)
  Nagase H and Yanagisawa M et al.
- Journal Title
  
  J Med Chem
  
  Volume: 60 Issue: 3 Pages: 1018-1040
- DOI
  10.1021/acs.jmedchem.6b01418
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-15H05935, KAKENHI-PROJECT-26220207, KAKENHI-PROJECT-16H05098, KAKENHI-PROJECT-15H06606, KAKENHI-PROJECT-15K19195, KAKENHI-PROJECT-15K16557
[Journal Article] 睡眠覚醒を制御する世界初の分子：オレキシン２受容体作動薬YNT-185の創製2016
- Author(s)
  斉藤　毅，長瀬　博
- Journal Title
  
  和光純薬時報
  
  Volume: 84 Pages: 2-5
- Data Source
  KAKENHI-PROJECT-16H05098
[Journal Article] 睡眠覚醒を制御する世界初の分子：オレキシン２受容体作動薬YNT-185の創製2016
- Author(s)
  斉藤　毅，長瀬　博
- Journal Title
  
  和光純薬時報
  
  Volume: 84 Pages: 2-5
- Data Source
  KAKENHI-PROJECT-15K16557
[Journal Article] 低分子オレキシン受容体アゴニストの創製2016
- Author(s)
  斉藤　毅，長瀬　博
- Journal Title
  
  MEDCHEM NEWS
  
  Volume: 26 Pages: 90-96
- NAID
  130007383316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K16557
[Journal Article] 低分子オレキシン受容体アゴニストの創製2016
- Author(s)
  斉藤　毅，長瀬　博
- Journal Title
  
  MEDCHEM NEWS
  
  Volume: 26 Pages: 90-96
- NAID
  130007383316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05098
[Journal Article] Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists2015
- Author(s)
  Nagahara T, Saitoh T, Kutsumura N, Irukayama-Tomobe Y, Ogawa Y, Kuroda D, Gouda H, Kumagai H, Fujii H, Yanagisawa M, Nagase H
- Journal Title
  
  J. Med. Chem
  
  Volume: 58 Issue: 20 Pages: 7931-7937
- DOI
  10.1021/acs.jmedchem.5b00988
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-15K16557, KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-26220207
[Journal Article] Conophylline suppresses pancreatic stellate cells and improves islet fibrosis in Goto-Kakizaki rats2012
- Author(s)
  R.Saito, K.Umezawa, et al
- Journal Title
  
  Endocrinology
  
  Volume: 153 Pages: 621-630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Design and synthesis of biotinylated DHMEQ for direct identification of its target NF-κB components., 20112011
- Author(s)
  T.Saitoh, K.Umezawa, et al
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 21 Pages: 6293-6296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Patent] スルホンアミド誘導体またはその薬学的に許容される酸付加塩2017
- Inventor(s)
  長瀬博、斉藤毅、柳沢正史、入鹿山容子
- Industrial Property Rights Holder
  長瀬博、斉藤毅、柳沢正史、入鹿山容子
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Analysis of orexinergic function in chronic pain-like states2023
- Author(s)
  Kao Hashimoto, Yasuyuki Nagumo, Keita Iio, Yuki Saito, Yukiko Ishikawa, Noriki Kutsumura, Takeshi Sakurai, Masashi Yanagisawa, Tsuyoshi Saitoh, Hiroshi Nagase
- Organizer
  The 11th Annual WPI-IIIS Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] 鎮静作用を分離したκオピオイド受容体作動薬の創製2023
- Author(s)
  斉藤毅、梶野景太、谷田誠浩、徳田明久、南雲康行、長瀬博
- Organizer
  日本薬学会第143年会
- Invited
- Data Source
  KAKENHI-ORGANIZER-21H05111
[Presentation] Discovery of orexin receptor agonists2023
- Author(s)
  Tsuyoshi Saitoh
- Organizer
  The 15th International Symposium on VIP, PACAP and Related Peptides/The 1st International Society for Bioactive Peptides Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] オレキシン1受容体を介する疼痛制御メカニズムの解析2023
- Author(s)
  橋本佳応、南雲康行、飯尾啓太、齊藤夕貴、石川有紀子、沓村憲樹、櫻井武、柳沢正史、斉藤毅、長瀬博
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] 鎮静作用を分離したκオピオイド受容体作動薬の創製2023
- Author(s)
  斉藤毅、南雲康行、梶野景太、谷田誠浩、德田明久、寿野(池田) 千代、寿野良二、清水(小林) 拓也、長瀬博
- Organizer
  第４２回鎮痛薬・オピオイドペプチドシンポジウム
- Invited
- Data Source
  KAKENHI-ORGANIZER-21H05111
[Presentation] Re:ゼロから始めるメドケム研究2023
- Author(s)
  斉藤毅
- Organizer
  第５６回天然物化学談話会
- Invited
- Data Source
  KAKENHI-ORGANIZER-21H05111
[Presentation] 三次元配向制御に立脚したオレキシン受容体作動薬の創製2023
- Author(s)
  斉藤毅
- Organizer
  日本薬学会第143年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] オレキシン1受容体選択的作動薬の設計と合成2023
- Author(s)
  長谷川大晟、飯尾啓太、石川有紀子、沓村憲樹、柳沢正史、長瀬博、斉藤毅
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] 配座制御に基づく新規テトラリン型OX2R選択的作動薬の創製2023
- Author(s)
  栗林利明、雨澤真櫻、岡田卓大、大下隆一郎、山本直司、南雲康行、沓村憲樹、入鹿山容子、石川有紀子、柳沢正史、長瀬博、斉藤毅
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] 意識をハックする分子の創製2022
- Author(s)
  斉藤毅
- Organizer
  第９回慶應有機化学若手シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] 選択的オレキシン１受容体作動薬の設計と合成2022
- Author(s)
  飯尾啓太、斉藤毅、橋本佳応、南雲康行、雨澤真櫻、長谷川大晟、石川有紀子、山本直司、沓村憲樹、柳沢正史、長瀬博
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] 2-メチルテトラリン誘導体を用いたオレキシン受容体作動薬の開発2022
- Author(s)
  雨澤真櫻、斉藤毅、岡田卓大、大下隆一郎、山本直司、南雲康行、沓村憲樹、入鹿山容子、石川有紀子、柳沢正史、長瀬博
- Organizer
  第66回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] 生理作用の因数分解：副作用のない薬の創製を目指して2022
- Author(s)
  斉藤毅、梶野景太、谷田誠浩、徳田明久、南雲康行、長瀬博
- Organizer
  第95回日本生化学会大会
- Invited
- Data Source
  KAKENHI-ORGANIZER-21H05111
[Presentation] TriMER骨格を用いたGPCRリガンド探索ツールの開発2022
- Author(s)
  雨澤真櫻、斉藤毅、山本直司、南雲康行、沓村憲樹、石川有紀子、柳沢正史、長瀬博
- Organizer
  第17回GPCR研究会
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] 1,3,5-Trioxazatriquinane骨格を用いたオレキシン受容体作動薬の創製2022
- Author(s)
  雨澤真櫻、斉藤毅、山本直司、南雲康行、沓村憲樹、石川有紀子、柳沢正史、長瀬博
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] Discovery of novel orexin receptor agonists carrying naphthalene skeleton2022
- Author(s)
  Tsuyoshi Saitoh
- Organizer
  The 15th International Symposium on Organic Reactions (ISOR-15)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] 分子の形に注目した創薬研究2022
- Author(s)
  斉藤毅
- Organizer
  日本薬学会第１４２年会
- Invited
- Data Source
  KAKENHI-ORGANIZER-21H05111
[Presentation] 意識をハックする分子の創製2022
- Author(s)
  斉藤毅
- Organizer
  第９回慶應有機化学若手シンポジウム
- Invited
- Data Source
  KAKENHI-ORGANIZER-21H05111
[Presentation] Design and synthesis of 17-N-fluoroalkyl nalfurafine derivatives to improve pharmacological properties2021
- Author(s)
  Natsumi Sakamoto; Tsuyoshi Saitoh; Yukiko Ishikawa; Akihisa Tokuda; Tsubasa Hino; Naoshi Yamamoto; Yasuyuki Nagumo; Noriki Kutsumura; Masashi Yanagisawa; Hiroshi Nagase
- Organizer
  The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem)
- Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-21H05111
[Presentation] Design and Synthesis of Novel Orexin Receptor Antagonists with 1,3,5-Trioxazatriquinane skeleton2021
- Author(s)
  Mao Amezawa; Jumpei Horiuchi; Tsuyoshi Saitoh; Ryuichiro Ohshita; Naoshi Yamamoto; Yasuyuki Nagumo; Yukiko Ishikawa; Yoko Irukayama; Emi Hasegawa; Noriki Kutsumura; Ryuji Tanimura; Sakurai Takeshi; Masashi Yanagisawa; Hiroshi Nagase
- Organizer
  AIMECS2021
- Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-21H05111
[Presentation] Discovery of novel orexin receptor antagonists with 1,3,5-trioxazatriquinane skeleton2021
- Author(s)
  Mao Amezawa; Tsuyoshi Saitoh; Yukiko Ishikawa; Yoko Irukayama; Emi Hasegawa; Hiroaki Gouda; Naoshi Yamamoto; Noriki Kutsumura; Yasuyuki Nagumo; Sakurai Takeshi; Masashi Yanagisawa; Hiroshi Nagase
- Organizer
  The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem)(国際学会)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] Design and Synthesis of Novel Orexin Receptor Dual Agonists with Tetralin Skeleton2021
- Author(s)
  Keita Iio, Tsuyoshi Saitoh, Ryuichiro Ohshita, Tsubasa Hino, Mao Amezawa, Sayaka Ohrui, Takahiro Okada, Yasuyuki Nagumo, Naoshi Yamamoto, Yukiko Ishikawa, Yoko Irukayama-Tomobe, Noriki Kutsumura, Masashi Yanagisawa, Hiroshi Nagase
- Organizer
  AIMECS2021
- Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-21H05111
[Presentation] Synthesis of unnatural morphinan compounds to induce itch like behavior in mice: Towards the development of MRGPRX2 selective ligands2021
- Author(s)
  Keita Iio; Noriki Kutsumura; Yasuyuki Nagumo; Tsuyoshi Saitoh; Naoshi Yamamoto; Akihisa Tokuda; Kao Hashimoto; Hirokazu Mizoguchi; Hiroshi Nagase
- Organizer
  The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem)
- Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-21H05111
[Presentation] Discovery of novel orexin receptor antagonists with 1,3,5-trioxazatriquinane skeleton2021
- Author(s)
  Mao Amezawa; Tsuyoshi Saitoh; Yukiko Ishikawa; Yoko Irukayama; Emi Hasegawa; Hiroaki Gouda; Naoshi Yamamoto; Noriki Kutsumura; Yasuyuki Nagumo; Sakurai Takeshi; Masashi Yanagisawa; Hiroshi Nagase
- Organizer
  The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem)
- Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-21H05111
[Presentation] Design and synthesis of novel morphinan-type κ opioid receptor agonists bearing bicyclo[2.2.2]octane skeleton and these pharmacological activities2021
- Author(s)
  Keita Kajino; Masahiro Yata; Tsuyoshi Saitoh; Naoshi Yamamoto; Yasuyuki Nagumo; Tsubasa Hino; Akihisa Tokuda; Noriki Kutsumura; Hiroshi Nagase
- Organizer
  The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem)
- Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-21H05111
[Presentation] Design and Synthesis of Novel Orexin Receptor Antagonists with 1,3,5-Trioxazatriquinane skeleton2021
- Author(s)
  Mao Amezawa; Jumpei Horiuchi; Tsuyoshi Saitoh; Ryuichiro Ohshita; Naoshi Yamamoto; Yasuyuki Nagumo; Yukiko Ishikawa; Yoko Irukayama; Emi Hasegawa; Noriki Kutsumura; Ryuji Tanimura; Sakurai Takeshi; Masashi Yanagisawa; Hiroshi Nagase
- Organizer
  AIMECS2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] Design and Synthesis of Novel Orexin Receptor Dual Agonists with Tetralin Skeleton2021
- Author(s)
  Keita Iio, Tsuyoshi Saitoh, Ryuichiro Ohshita, Tsubasa Hino, Mao Amezawa, Sayaka Ohrui, Takahiro Okada, Yasuyuki Nagumo, Naoshi Yamamoto, Yukiko Ishikawa, Yoko Irukayama-Tomobe, Noriki Kutsumura, Masashi Yanagisawa, Hiroshi Nagase
- Organizer
  AIMECS2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] Why are we sleepy when bored? Astroglial regulation of sleep in the nucleus accumbens2020
- Author(s)
  Xuzhao Zhou, Tsuyoshi Saitoh, Zhaofa Wu, Yulong Li, Michael Lazarus
- Organizer
  Cold Spring Harbor Laboratory Meetings - Glia in Health & Disease (Virtual)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02215
[Presentation] Development of small molecules which regulate the sleep/wake cycle2020
- Author(s)
  T. Saitoh
- Organizer
  The 140th Annual Meeting of the Pharmacological Society of Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14352
[Presentation] In vitro and in vivo pharmacology of small-molecule orexin agonists for treatment of narcolepsy2019
- Author(s)
  1.Namekawa Y, Irukayama-Tomobe Y, Ishikawa Y, Yamaguchi T, Ogawa Y, Nemoto T, Tanaka H, Yamamoto H, Tito Akindele, Saitoh T, Nagase H, Yanagisawa M
- Organizer
  Tsukuba Global Science Week
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11014
[Presentation] アデノシン2A受容体を標的とした新規光ケージド薬物の創製2019
- Author(s)
  斉藤毅、井岡秀二、Mustafa Korkutata、千歳洋平、Kaspar Vogt、安倍学、Michael Lazarus、長瀬博
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-18K14352
[Presentation] Essential structure of orexin 1 receptor antagonist YNT-7072019
- Author(s)
  S. Ohrui, N. Yamamoto, T. Okada, M. Yata, T. Saitoh, N. Kutsumura, Y. Nagumo, Y. Irukayama-Tomobe, Y. Ishikawa, Y. Ogawa, Y. Watanabe, D. Hayakawa, H. Gouda, M. Yanagisawa, H. Nagase
- Organizer
  27th International Society of Heterocyclic Chemistry Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14352
[Presentation] Discovery of Novel Orexin Receptor Antagonists with 1,3,5-Trioxazatriquinane Skeleton2019
- Author(s)
  M. Amezawa, J. Horiuchi, T. Saitoh, R. Ohshita, Y. Ogawa, Y. Ishikawa, Y. Irukayama, E. Hasegawa, D. Hayakawa, Y. Watanabe, Y. Nagumo, N. Yamamoto, N. Kutsumura, H. Gouda, T. Sakurai, M. Yanagisawa, H. Nagase
- Organizer
  The 27th French-Japanese Symposium on Medicinal and Fine Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14352
[Presentation] Development of photocaged adenosine 2A receptor activator2019
- Author(s)
  Tsuyoshi Saitoh, Shuji Ioka, Mustafa Korkutata, Yohei Chitose, Manabu Abe, Michael Lazarus, Hiroshi Nagase
- Organizer
  13th International Symposium on Organic Reactions (ISOR-13)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14352
[Presentation] 新規低分子量オレキシン2型受容体作動薬、YNT-Xの薬理作用2019
- Author(s)
  滑川由紀子、入鹿山容子、小川靖裕、石川由紀子、山口拓土、アキンデレチト、斉藤毅、長瀬博、柳沢正史
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K14352
[Presentation] Discovery of Novel Orexin Receptor Antagonist with 1,3,5-Trioxazatriquinane Skeleton2019
- Author(s)
  3.Amezawa M, Horiuchi J, Saitoh T, Ogawa Y, Ishikawa Y, Irukayama Y, Hasegawa E, Hayakawa D, Watanabe Y, Nagumo Y, Yamamoto N, Kutsumura N, Gouda H, Sakurai T, Yanagisawa M, Nagase H.
- Organizer
  The 27th French-Japanese Symposium on Medicinal and Fine Chemistry Hotel Leopalace Hakata
- Data Source
  KAKENHI-PROJECT-18K11014
[Presentation] Essential structure of orexin 1 receptor antagonist YNT-7072019
- Author(s)
  2.Ohrui S, Yamamoto N, Okada T, Yata M, Saitoh T, Kutsumura N, Nagumo N, Irukayama-Tomobe Y, Ishikawa Y, Ogawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H.
- Organizer
  27th International Society of HeterocyclicChemistry Congress ROHM Theatre Kyoto & Miyakomesse
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11014
[Presentation] 光ケージドadenosine 2A受容体ポジティブアロステリックモジュレーターの開発2018
- Author(s)
  井岡秀二、斉藤毅、千歳洋平、Mustafa Korkutata、安部学、Michael Lazarus、長瀬博
- Organizer
  日本ケミカルバイオロジー学会第13回年会
- Data Source
  KAKENHI-PROJECT-18K14352
[Presentation] Non-peptidic Orexin receptor type-2 agonist attenuates body weight gain of high-fat fed mice2018
- Author(s)
  1.Eriya Takahashi*, Kyoko Enomoto, Takuto Yamaguchi, Yasuhiro Ogawa, Shoji Fukusumi, Akari Kawai, Masaya Araki, Tsuyoshi Saitoh, Yoshimi Nakagawa, Yoko Irukayama-Tomobe, Hitoshi Shimano, Hiroshi Nagase, Masashi Yanagisawa
- Organizer
  The 41st Annual Meeting of the Japan Neuroscience Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11014
[Presentation] 1,3,5-Trioxazatriquinane骨格を有するトリマーの合成とオレキシン受容体拮抗活性評価2018
- Author(s)
  雨澤真櫻、堀内惇平、斉藤　毅、大下隆一郎、小川靖裕、石川有紀子、入鹿山容子、長谷川恵美、南雲康行、山本直司、沓村憲樹、早川大地、渡邉友里江、合田浩明、櫻井　武、柳沢正史、長瀬　博
- Organizer
  第62回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] 睡眠覚醒を標的とする創薬研究2017
- Author(s)
  斉藤毅
- Organizer
  第４回次世代の有機化学・広島シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] 低分子量オレキシン受容体2型作動薬YNT-185の組織学的、及び電気生理学的解析2017
- Author(s)
  小川　靖裕、入鹿山　容子、富永　拡、細川　直人、斉藤　毅、長瀬　博、柳沢　正史
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎新聞文化ホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] オレキシン１受容体拮抗薬YNT-707の必須構造部位検討2017
- Author(s)
  大類彩、山本直司、岡田卓大、谷田誠浩、斉藤毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、渡邊友里恵、早川大地、合田浩明、柳沢正史、長瀬博
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] モルヒナン骨格を有するオレキシン1受容体（OX1R）の特異的拮抗薬の設計・合成とOX1R結合の活性立体配座2017
- Author(s)
  山本直司、大類彩、岡田卓大、谷田誠浩、斉藤毅、沓村憲樹、南雲康行、入鹿山容子、小川靖裕、石川有紀子、平山重人、渡辺友里恵、早川大地、合田浩明、柳沢正史、長瀬博
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] 低分子量オレキシン受容体2型作動薬YNT-185の組織学的、及び電気生理学的解析2017
- Author(s)
  小川靖裕、入鹿山容子、富永拡、細川直人、斉藤毅、長瀬博、柳沢正史
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎新聞文化ホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] キャップトリマー骨格を有するオレキシン受容体拮抗薬の設計・合成12017
- Author(s)
  堀内惇平、大下隆一郎、南雲康行、山本直司、沓村憲樹、斉藤毅、入鹿山容子、石川有紀子、小川靖裕、柳沢正史、長瀬博
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] 睡眠覚醒を標的とする創薬研究2017
- Author(s)
  斉藤毅
- Organizer
  第4回次世代の有機化学・広島シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] 大学における創薬研究とクロマトグラフィー2017
- Author(s)
  斉藤毅
- Organizer
  分取クロマトセミナー2017
- Invited
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] オレキシン１受容体拮抗薬YNT-707の必須構造部位検討2017
- Author(s)
  大類彩、山本直司、岡田卓大、谷田誠浩、斉藤毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、渡邊友里恵、早川大地、合田浩明、柳沢正史、長瀬博
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] 新規低分子量オレキシン受容体作動薬YNT-185の全身炎症後の活動回復作用の検討2017
- Author(s)
  内田俊太郎、入鹿山容子、小川靖裕、富永拡、石川ゆい、木山麻衣子、斉藤毅、長瀬博、柳沢正史
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎新聞文化ホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] キャップトリマー骨格を有するオレキシン受容体拮抗薬の設計・合成22017
- Author(s)
  大下隆一郎、堀内惇平、南雲康行、山本直司、沓村憲樹、斉藤毅、入鹿山容子、石川有紀子、小川靖裕、柳沢正史、長瀬博
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Design and synthesis of orexin 1 receptor selective antagonists2017
- Author(s)
  Sayaka Ohrui, Naoshi Yamamoto, Masahiro Yata, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Shigeto Hirayama, Masashi Yanagisawa, Hiroshi Nagase
- Organizer
  Tsukuba Global Science Week (TGSW) 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] モルヒナン骨格を有するオレキシン1受容体（OX1R）の特異的拮抗薬の設計・合成とOX1R結合の活性立体配座2017
- Author(s)
  山本直司、大類彩、岡田卓大、谷田誠浩、斉藤毅、沓村憲樹、南雲康行、入鹿山容子、小川靖裕、石川有紀子、平山重人、渡辺友里恵、早川大地、合田浩明、柳沢正史、長瀬博
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Design and synthesis of orexin 1 receptor selective antagonists2017
- Author(s)
  Sayaka Ohrui, Naoshi Yamamoto, Masahiro Yata, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Shigeto Hirayama, Masashi Yanagisawa, Hiroshi Nagase
- Organizer
  Tsukuba Global Science Week (TGSW) 2017
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] 新規低分子量オレキシン受容体作動薬YNT-185の全身炎症後の活動回復作用の検討2017
- Author(s)
  内田　俊太郎、入鹿山　容子、小川　靖裕、富永　拡、石川　ゆい、木山　麻衣子、斉藤　毅、長瀬　博、柳沢　正史
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎新聞文化ホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] オレキシン 2 受容体作動薬 YNT-185 の創製2016
- Author(s)
  斉藤毅、永原崇志、沓村憲樹、中嶋龍、細川直人、入鹿山容子、小川靖裕、富永拡、黒田大介、合田浩明、藤井秀明、柳沢正史、長瀬博
- Organizer
  第34回メディシナルケミストリーシンポジウム　サテライトセッション
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] 低分子オレキシン受容体アゴニストの創製2016
- Author(s)
  斉藤　毅、永原崇志、沓村憲樹、入鹿山容子、小川靖裕、富永　拡、黒田大介、合田浩明、藤井秀明、柳沢正史、長瀬　博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Invited
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Synthesis of Novel, Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton2016
- Author(s)
  Naoshi Yamamoto, Masahiro Yata, Sayaka Ohrui, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Daisuke Kuroda, Hiroaki Gouda, Masashi Yanagisawa, Hiroshi Nagase
- Organizer
  The 25th French-Japanese Symposium on Medicinal and Fine Chemistry
- Place of Presentation
  Keio Plaza Hotel Tama（東京都多摩市）
- Year and Date
  2016-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] モルヒナン骨格を有する新規オレキシン1受容体選択的拮抗薬の設計・合成①2016
- Author(s)
  大類　彩、山本直司、谷田誠浩、岡田卓大、斉藤　毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、柳沢正史、長瀬　博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] ナルフラフィンの構造を基にしたオレキシン1受容体選択的拮抗薬の設計・合成およびその薬理作用2016
- Author(s)
  山本直司、谷田誠浩、大類　彩、岡田卓大、斉藤　毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、平山重人、柳沢正史、長瀬　博
- Organizer
  第36回鎮痛薬・オピオイドペプチドシンポジウム
- Place of Presentation
  北海道大学（北海道札幌市）
- Year and Date
  2016-06-19
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] YNT-707のOX1Rアンタゴニスト活性発現のための必須構造の検討2016
- Author(s)
  関　知範、中嶋　龍、斉藤　毅、入鹿山容子、小川靖裕、石川有紀子、柳沢正史、長瀬　博
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] モルヒナン骨格を有する新規オレキシン1受容体選択的拮抗薬の設計・合成②2016
- Author(s)
  岡田卓大、山本直司、谷田誠浩、大類　彩、斉藤　毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、平山重人、柳沢正史、長瀬　博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] オレキシン2受容体作動薬の設計・合成2016
- Author(s)
  長瀬　博、永原　崇志、斉藤　毅、沓村　憲樹、入鹿山　容子、小川　靖裕、黒田　大祐、合田　浩明、藤井　秀明、柳沢　正史
- Organizer
  第36回鎮痛薬・オピオイドペプチドシンポジウム
- Place of Presentation
  北海道大学（北海道札幌市）
- Year and Date
  2016-08-19
- Invited
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] YNT-707のOX1R拮抗作用発現のための必須構造の検討2016
- Author(s)
  関　知範、中嶋　龍、斉藤　毅、入鹿山容子、小川靖裕、石川有紀子、柳沢正史、長瀬　博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] オレキシン2受容体作動薬の設計・合成2016
- Author(s)
  長瀬博、永原崇志、斉藤毅、沓村憲樹、入鹿山容子、小川靖裕、黒田大祐、合田浩明、藤井秀明、柳沢正史
- Organizer
  第36回鎮痛薬・オピオイドペプチドシンポジウム
- Place of Presentation
  北海道大学（北海道札幌市）
- Year and Date
  2016-08-19
- Invited
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] Development of non-peptide orexin receptor agonists for controlling sleep/wake cycle2016
- Author(s)
  Tsuyoshi Saitoh, Takashi Nagahara, Noriki Kutsumura, Yoko Irukayama, Yasuhiro Ogawa, Daisuke Kuroda, Hiroaki Gouda, Hideaki Fujii, Masashi Yanagisawa, Hiroshi Nagase
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  同志社大学京田辺キャンパス、京都府、京都市
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] 低分子オレキシン受容体アゴニストの創製2016
- Author(s)
  斉藤毅、永原崇志、沓村憲樹、入鹿山容子、小川靖裕、富永拡、黒田大介、合田浩明、藤井秀明、柳沢正史、長瀬博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Invited
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] オレキシン２受容体作動薬YNT-185の創製2016
- Author(s)
  斉藤　毅、永原崇志、沓村憲樹、中嶋　龍、細川直人、入鹿山容子、小川靖裕、富永　拡、黒田大介、合田浩明、藤井秀明、柳沢正史、長瀬　博
- Organizer
  第34回メディシナルケミストリーシンポジウム　サテライトセッション
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] モルヒナン骨格を有するオレキシン１受容体選択的拮抗薬の設計・合成とその薬理作用”2016
- Author(s)
  大類　彩、山本直司、谷田誠浩、岡田卓大、斉藤　毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、平山重人、柳沢正史、長瀬　博
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] 低分子オレキシン受容体アゴニストの創製2015
- Author(s)
  斉藤毅、永原崇志、沓村憲樹、入鹿山容子、小川靖裕、黒田大祐、合田浩明、藤井秀明、柳沢正史、長瀬博
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研修センター、千葉県、千葉市
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-15K16557
[Presentation] Discovery of novel orexin receptor agonists for controlling sleep/awake cycle2015
- Author(s)
  T. Saitoh, T. Nagahara, N. Kutsumura, Y. Irukayama, Y. Ogawa, H. Fujii, M. Yanagisawa, H. Nagase
- Organizer
  Pacifichem 2015
- Place of Presentation
  ヒルトンハワイアンビレッジ、ホノルル、アメリカ
- Year and Date
  2015-12-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16557

1. Suno Ryoji (60447521)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
2. 桜井武 (60251055)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
3. Yanagisawa Masashi (20202369)

# of Collaborated Projects: 3 results

# of Collaborated Products: 28 results
4. 南雲康行 (00459661)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
5. Nagase Hiroshi (70383651)

# of Collaborated Projects: 2 results

# of Collaborated Products: 35 results
6. Lazarus Michael (80469650)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. 入鹿山容子 (90312834)

# of Collaborated Projects: 2 results

# of Collaborated Products: 26 results
8. 櫻井勝康 (70507920)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
9. UMEZAWA Kazuo (70114402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SIMIZU Siro (30312268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. ISHIKAWA Yuichi (40348826)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OZAKI Michitaka (80256510)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. HAGA Sanae (60706505)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KOBAYASHI Takuya (20311730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Fukusumi Shoji (10750002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 高田陽子 (60435740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 大石陽 (70554004)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 野村紀通 (10314246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 井上飛鳥 (50525813)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 阿部高志 (00549644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 本城咲季子 (30551379)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 林悠 (40525812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 史蕭逸 (40803656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 坂口昌徳 (60407088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 坪田有沙 (60806230)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. Vogt Kaspar (80740034)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 征矢英昭 (50221346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 岡本正洋 (30726617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 土屋輝一郎 (40376786)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 寺谷俊昭 (40624408)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. Kobilka Brian K

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 梅沢一夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
33. 沓村憲樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
34. 酒井寿郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 熊谷英敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAITOH Tsuyoshi 斉藤 毅

Saitoh Tsuyoshi 斎藤 毅

SAITO Tsuyoshi 斉藤 毅

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Development of novel chemical tools targeting orexin 1 receptorsPrincipal Investigator

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Construction of morphinan-based focused libraryPrincipal Investigator

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Multi-scale platform for untangling physiological complexityArea Organizer

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Multi-scale platform for untangling physiological complexityPrincipal Investigator

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Development of novel PET probes targeting orexin 1 receptorPrincipal Investigator

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Development of novel photochemical tools to regulate wakefulnessPrincipal Investigator

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Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

SAITOH Tsuyoshi 斉藤毅

Saitoh Tsuyoshi 斎藤毅

SAITO Tsuyoshi 斉藤毅