Nagase Hiroshi 長瀬博

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NAGASE Hiroshi 長瀬博

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Researcher Number	70383651
Other IDs
Affiliation (Current)	2025: 筑波大学, 国際統合睡眠医科学研究機構, 名誉教授
Affiliation (based on the past Project Information) *help	2022: 筑波大学, 国際統合睡眠医科学研究機構, 名誉教授 2015 – 2021: 筑波大学, 国際統合睡眠医科学研究機構, 教授 2018: 筑波大学, 国際統合睡眠医科学研究機構, 特命教授 2015: 筑波大学, 学内共同利用施設等, 教授 2013: 筑波大学, 国際統合睡眠医科学研究機構, 教授 2007 – 2008: Kitasato University, 薬学部, 教授
Review Section/Research Field	Principal Investigator Drug development chemistry / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Complex systems Except Principal Investigator Complex systems / Drug development chemistry
Keywords	Principal Investigator オレキシン / 作動薬 / オレキシン受容体 / 創薬化学 / 睡眠 / 拮抗薬 / オピオイド / 機能解明 / 薬理評価 / オレキシン１受容体 … More / GPCR / アゴニスト / 分子設計 / オレキシン1受容体 / ナルコレプシー / 覚醒 / ナルフラフィン / 有機合成化学 / OX2R作動薬 / OX1R拮抗薬 / モルフィナン骨格 / OX1R作動薬 / モルヒナン / ストレス / オレキシン受容体作動薬 / 睡眠覚醒制御遺伝子 / 宇宙飛行士 / 不眠症治療薬 / 睡眠診断法 / 医薬分子設計 / 生物活性物質 … More Except Principal Investigator 破綻 / 可塑性 / 放射線影響 / 宇宙環境 / 宇宙医学 / 社会医学 / 特殊環境 / 無重力 / 微生物 / 放射線 / ストレス / 微小重力 / 宇宙 / ファーマコフォー / κ作動薬 / オピオイド / 受容体ダイマー / 医薬分子設計 Less

Development of novel selective orexin 1 receptor agonists and elucidation of the function of orexin receptorsPrincipal Investigator
- Principal Investigator
  
  Nagase Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  University of Tsukuba
Development of novel orexin ligand and its pharmacological activityPrincipal Investigator
- Principal Investigator
  
  Nagase Hiroshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  University of Tsukuba
Integral Understanding of Life-regulation Mechanism from "SPACE"
- Principal Investigator
  
  Furukawa Satoshi
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Japan Aerospace EXploration Agency
Development of a new sleep-wake control method for super stress environment, SpacePrincipal Investigator
- Principal Investigator
  
  Nagase Hiroshi
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  University of Tsukuba
Investigation of the relationship between opioid kappa receptor subtype and receptor dimerization
- Principal Investigator
  
  FUJII Hideaki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kitasato University
Investigation of binding sites of agonists or antagonists on opioid receptor ligandsPrincipal Investigator
- Principal Investigator
  
  NAGASE Hiroshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kitasato University

[Book] アルカロイドの科学2016
- Author(s)
  長瀬　博, 沓村　憲樹
- Publisher
  化学同人
- Data Source
  KAKENHI-PLANNED-15H05942
[Book] Arch Pharm Chem Life Sci「Synthesis of novel triplets with a 1,3,5-trioxazatriquinane skeleton and their pharmacologies for opioid receptors」2015
- Author(s)
  Nagase H, Katsunuma N
- Total Pages
  15
- Publisher
  Wiley
- Data Source
  KAKENHI-ORGANIZER-15H05935
[Book] 平成27年度日本薬学会医薬化学部会賞を受賞し、Med Chem Newsに掲載「低分子オレキシン受容体アゴニストの創製」2015
- Author(s)
  斉藤毅、長瀬博
- Total Pages
  7
- Publisher
  日本薬学会
- Data Source
  KAKENHI-ORGANIZER-15H05935
[Journal Article] Design and synthesis of novel orexin 2 receptor agonists with a 1,3,5-trioxazatriquinane skeleton2023
- Author(s)
  Mao Amezawa, Naoshi Yamamoto, Yasuyuki Nagumo, Noriki Kutsumura, Yukiko Ishikawa, Masashi Yanagisawa, Hiroshi Nagase, Tsuyoshi Saitoh
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 82 Pages: 129151-129151
- DOI
  10.1016/j.bmcl.2023.129151
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H04918, KAKENHI-ORGANIZER-21H05111, KAKENHI-PROJECT-20H03361
[Journal Article] Design and Synthesis of Orexin 1 Receptor-Selective Agonists2023
- Author(s)
  Keita Iio, Kao Hashimoto, Yasuyuki Nagumo, Mao Amezawa, Taisei Hasegawa, Naoshi Yamamoto, Noriki Kutsumura, Katsuhiko Takeuchi, Yukiko Ishikawa, Hikari Yamamoto, Akihisa Tokuda, Tetsu Sato, Yasuo Uchida, Asuka Inoue, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase, Tsuyoshi Saitoh
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 66 Issue: 8 Pages: 5453-5464
- DOI
  10.1021/acs.jmedchem.2c01773
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H04918, KAKENHI-ORGANIZER-21H05111, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-20H03361
[Journal Article] Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring2022
- Author(s)
  Keita Iio, Tsuyoshi Saitoh, Ryuichiro Ohshita, Tsubasa Hino, Mao Amezawa, Yoshiaki Takayama, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kustumura, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 60 Pages: 128555-128555
- DOI
  10.1016/j.bmcl.2022.128555
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-21H05111, KAKENHI-PROJECT-20H03361, KAKENHI-PROJECT-19K07314
[Journal Article] Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton2022
- Author(s)
  Tsubasa Hino, Tsuyoshi Saitoh, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 59 Pages: 128530-128530
- DOI
  10.1016/j.bmcl.2022.128530
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-21H05111, KAKENHI-PROJECT-20H03361, KAKENHI-PROJECT-19K07314
[Journal Article] Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) librasy2022
- Author(s)
  Saitoh T, Amezawa M, Horiuchi J, Nagumo Y, Yamamoto N, Kutsumura N, Ohshita R, Tokuda A, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Hasegawa E, Sakurai T, Uchida Y, Sato T, Gouda H, Tanimura R, Yanagisawa M, Nagase H.
- Journal Title
  
  Eur J Med Chem
  
  Volume: 240 Pages: 114505-27
- DOI
  10.1016/j.ejmech.2022.114505
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07314, KAKENHI-PROJECT-22H04918, KAKENHI-ORGANIZER-21H05111, KAKENHI-PROJECT-20H03361
[Journal Article] Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine2020
- Author(s)
  Nagumo Yasuyuki、Katoh Koki、Iio Keita、Saitoh Tsuyoshi、Kutsumura Noriki、Yamamoto Naoshi、Ishikawa Yukiko、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Baba Takeshi、Tanimura Ryuji、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 30 Issue: 17 Pages: 127360-127360
- DOI
  10.1016/j.bmcl.2020.127360
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05710, KAKENHI-PROJECT-19K07314, KAKENHI-PROJECT-18K11014, KAKENHI-ORGANIZER-15H05935, KAKENHI-WRAPUP-20H05615
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring2019
- Author(s)
  Yamamoto Naoshi、Ohrui Sayaka、Okada Takahiro、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Issue: 8 Pages: 1747-1758
- DOI
  10.1016/j.bmc.2019.03.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-18K11014, KAKENHI-PROJECT-19K07314, KAKENHI-PROJECT-18K14352, KAKENHI-PROJECT-16H05098
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity2018
- Author(s)
  Ohrui Sayaka、Yamamoto Naoshi、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 28 Issue: 4 Pages: 774-777
- DOI
  10.1016/j.bmcl.2017.12.069
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-15K16557, KAKENHI-PROJECT-16H05098
[Journal Article] Enhancing endogenous adenosine A2A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function2018
- Author(s)
  Korkutata M, Saitoh T, Cherasse Y, Ioka S, Duo F, Qin R, Murakoshi N, Fujii S, Zhou X, Sugiyama F, Chen JF, Kumagai H, Nagase H, Lazarus M
- Journal Title
  
  Neuropharmacology
  
  Volume: 144 Pages: 122-132
- DOI
  10.1016/j.neuropharm.2018.10.022
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-INTERNATIONAL-15K21745, KAKENHI-PUBLICLY-18H04966, KAKENHI-PROJECT-17H02215, KAKENHI-PROJECT-16K18698, KAKENHI-ORGANIZER-15H05935
[Journal Article] 宇宙環境における睡眠問題の解決2018
- Author(s)
  長瀬博、北川博之、船戸弘正、阿部高志、小久保利雄
- Journal Title
  
  生体の科学
  
  Volume: 69 Pages: 138-141
- Data Source
  KAKENHI-PROJECT-16H05098
[Journal Article] Synthesis of novel 1,3-dioxa-5-thiazatriquinane and 1-oxa-3,5-dithiazatriquinane derivatives and their pharmacologies2018
- Author(s)
  Ohshita R, Kutsumura N, Nagumo Y, Yamamoto N, Saitoh T, Hirayama S, Fujii H, and Nagase H*
- Journal Title
  
  Heterocycles
  
  Volume: 97 Issue: 2 Pages: 687-695
- DOI
  10.3987/com-18-s(t)40
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-15H05942, KAKENHI-ORGANIZER-15H05935
[Journal Article] Favorskii-Type Rearrangement of the 4,5-Epoxymorphinan Skeleton2018
- Author(s)
  Kutsumura Noriki、Koyama Yasuaki、Suzuki Yuko、Tominaga Ken-ichi、Yamamoto Naoshi、Saitoh Tsuyoshi、Nagumo Yasuyuki、Nagase Hiroshi
- Journal Title
  
  Organic Letters
  
  Volume: 20 Issue: 6 Pages: 1559-1562
- DOI
  10.1021/acs.orglett.8b00288
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13259, KAKENHI-PROJECT-16H05098
[Journal Article] Acetic Anhydride Mediated Retro-Ene Reaction via a [4.4.3]Propellane Skeleton Intermediate Containing a Quaternary Ammonium Linkage2018
- Author(s)
  Kutsumura N and Nagase H, et al.
- Journal Title
  
  Synthesis
  
  Volume: 20 Issue: 21 Pages: 1559-1562
- DOI
  10.1055/s-0036-1589138
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05942
[Journal Article] Unique Reactions of Morphinan Skeletons and Conversions of the Skeletons to Active Alkaloids2018
- Author(s)
  沓村憲樹、長瀬　博
- Journal Title
  
  Journal of Synthetic Organic Chemistry, Japan
  
  Volume: 76 Issue: 9 Pages: 914-921
- DOI
  10.5059/yukigoseikyokaishi.76.914
- NAID
  130007472397
- ISSN
  0037-9980, 1883-6526
- Year and Date
  2018-09-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K13259, KAKENHI-PROJECT-16H05098
[Journal Article] オレキシン受容体を標的としたナルコレプシー治療薬の開発2018
- Author(s)
  斉藤毅、長瀬博
- Journal Title
  
  バイオサイエンスとインダストリー（B&I）
  
  Volume: 76 Pages: 127-129
- NAID
  40021512201
- Data Source
  KAKENHI-PROJECT-16H05098
[Journal Article] Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models2017
- Author(s)
  Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 114 Issue: 22 Pages: 5731-5736
- DOI
  10.1073/pnas.1700499114
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-16H06400, KAKENHI-PROJECT-15H03122, KAKENHI-PROJECT-15K16557, KAKENHI-PROJECT-16H05098
[Journal Article] IIIS発　ナルコレプシー治療薬開発に向けた取り組み2017
- Author(s)
  斉藤毅、入鹿山容子、柳沢正史、長瀬博
- Journal Title
  
  なるこ
  
  Volume: 34 Pages: 8-10
- Data Source
  KAKENHI-PROJECT-16H05098
[Journal Article] The application of a specific morphinan template to the synthesis of galanthamine2017
- Author(s)
  Yamamoto Naoshi、Okada Takahiro、Harada Yukimasa、Kutsumura Noriki、Imaide Satomi、Saitoh Tsuyoshi、Fujii Hideaki、Nagase Hiroshi
- Journal Title
  
  Tetrahedron
  
  Volume: 73 Issue: 39 Pages: 5751-5758
- DOI
  10.1016/j.tet.2017.08.014
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05098
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor2017
- Author(s)
  Yamamoto Naoshi、Ohrui Sayaka、Okada Takahiro、Yata Masahiro、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 27 Issue: 17 Pages: 4176-4179
- DOI
  10.1016/j.bmcl.2017.07.011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-15K16557, KAKENHI-PROJECT-16H05098, KAKENHI-ORGANIZER-15H05935
[Journal Article] Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies2017
- Author(s)
  Nagase H and Yanagisawa M et al.
- Journal Title
  
  J Med Chem
  
  Volume: 60 Issue: 3 Pages: 1018-1040
- DOI
  10.1021/acs.jmedchem.6b01418
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-15H05935, KAKENHI-PROJECT-26220207, KAKENHI-PROJECT-16H05098, KAKENHI-PROJECT-15H06606, KAKENHI-PROJECT-15K19195, KAKENHI-PROJECT-15K16557
[Journal Article] 睡眠覚醒を制御する世界初の分子：オレキシン２受容体作動薬YNT-185の創製2016
- Author(s)
  斉藤　毅，長瀬　博
- Journal Title
  
  和光純薬時報
  
  Volume: 84 Pages: 2-5
- Data Source
  KAKENHI-PROJECT-16H05098
[Journal Article] 内因性オピオイドの痒みへの関与と痒み調節機構の解明2016
- Author(s)
  長瀬　博, 沓村　憲樹
- Journal Title
  
  JOHNS
  
  Volume: 32 Pages: 564-567
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-15H05942
[Journal Article] 低分子オレキシン受容体アゴニストの創製2016
- Author(s)
  斉藤毅, 長瀬博
- Journal Title
  
  MedChem News
  
  Volume: 26(2) Pages: 90-96
- NAID
  130007383316
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-15H05942
[Journal Article] 24.Nagase H., N. Yamamoto, and M. Yanagisawa et al. Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies2016
- Author(s)
  Nagase H., N. Yamamoto, and M. Yanagisawa et al.
- Journal Title
  
  J. Med. Chem.
  
  Volume: 60 Pages: 1018-1040
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-15H05942
[Journal Article] オレキシンの神経科学と創薬2016
- Author(s)
  櫻井　武, 長瀬　博
- Journal Title
  
  MEDCHEM NEW
  
  Volume: 26 Pages: 170-175
- NAID
  130006510952
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05098
[Journal Article] Intrathecal morphine-3-glucuronide-induced nociceptive behavior via δ-2 opioid receptors in the spinal cord2016
- Author(s)
  Takaaki Komatsu, Soh Katsuyama, Hiroshi Nagase, Hirokazu Mizoguchi, Chikai Sakurada, Minoru Tsuzuki, Shinobu Sakurada, Tsukasa Sakurada
- Journal Title
  
  Pharmacology Biochemistry & Behavior
  
  Volume: 140 Pages: 68-74
- DOI
  10.1016/j.pbb.2015.10.010
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08678, KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-25460725
[Journal Article] 低分子オレキシン受容体アゴニストの創製2016
- Author(s)
  斉藤　毅，長瀬　博
- Journal Title
  
  MEDCHEM NEWS
  
  Volume: 26 Pages: 90-96
- NAID
  130007383316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05098
[Journal Article] 難治性掻痒症治療薬　ナルフラフィンの研究開発2016
- Author(s)
  長瀬　博, 沓村　憲樹
- Journal Title
  
  SAR News
  
  Volume: ３０ Pages: 2-7
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-15H05942
[Journal Article] Opioid systems in the lateral hypothalamus regulate feeding behavior through orexin and GABA neurons.2016
- Author(s)
  Ardianto C, Yonemochi N, Yamamoto S, Yang L, Takenoya F, Shioda S, Nagase H, Ikeda H, Kamei J.
- Journal Title
  
  Neuroscience.
  
  Volume: 320 Pages: 183-193
- DOI
  10.1016/j.neuroscience.2016.02.002
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350912, KAKENHI-PROJECT-26430024, KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-23249079, KAKENHI-PROJECT-16H02684, KAKENHI-PROJECT-15K15670
[Journal Article] Naltrindole derivatives with fluorinated ethyl substituents on 17-nitrogen as delta opioid receptor inverse agonist2015
- Author(s)
  Nemoto T, Iihara Y, Hirayama S, Iwai T, Higashi E, Fujii H, Nagase H
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 25 Issue: 15 Pages: 2927-30
- DOI
  10.1016/j.bmcl.2015.05.038
- Peer Reviewed
- Data Source
  KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935
[Journal Article] Transformation of naltrexone into mesembrane and investigation of the binding properties of its intermediate derivatives to opioid receptors2015
- Author(s)
  Konoura K, Fujii H, Imaide S, Gouda H, Hirayama S, Hirono S, Nagase H
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 23 Issue: 3 Pages: 439-48
- DOI
  10.1016/j.bmc.2014.12.032
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942
[Journal Article] 難治性そう痒症治療薬レミッチ®カプセルの創出2015
- Author(s)
  長瀬　博
- Journal Title
  
  医薬の門
  
  Volume: 54 Pages: 20-24
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-15H05942
[Journal Article] Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain2015
- Author(s)
  Nakajima R, Yamamoto N, Hirayama S, Iwai T, Saitoh A, Nagumo Y, Fujii H, Nagase H.
- Journal Title
  
  Bioorg Med Chem.
  
  Volume: 23 Issue: 19 Pages: 6271-6279
- DOI
  10.1016/j.bmc.2015.08.036
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19195, KAKENHI-PROJECT-26860076, KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-15J03517
[Journal Article] Inhibition of opioid systems in the hypothalamus as well as the mesolimbic area suppresses feeding behavior of mice2015
- Author(s)
  Ikeda H, Ardianto C, Yonemochi N, Yang L, Ohashi T, Ikegami M, Nagase H, Kamei J
- Journal Title
  
  Neuroscience
  
  Volume: 311 Pages: 9-21
- DOI
  10.1016/j.neuroscience.2015.10.002
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430024, KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942
[Journal Article] ナルフラフィン塩酸塩2015
- Author(s)
  長瀬　博
- Journal Title
  
  メディカル朝日[特集]混合ワクチン最前線　サムライたちのクスリPart II「ニッポン発の創薬」を目指して（12）
  
  Volume: 7 Pages: 66-69
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-15H05942
[Journal Article] Synthesis of Novel Triplets with a 1,3,5-Trioxazatriquinane Skeleton and their Pharmacologies for Opioid Receptors2015
- Author(s)
  H. Nagase, N. Kutsumura
- Journal Title
  
  Arch. Pharm. Chem. Life Sci.
  
  Volume: 348 Issue: 6 Pages: 375-389
- DOI
  10.1002/ardp.201500031
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05942
[Journal Article] Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists2015
- Author(s)
  Nagahara T, Saitoh T, Kutsumura N, Irukayama-Tomobe Y, Ogawa Y, Kuroda D, Gouda H, Kumagai H, Fujii H, Yanagisawa M, Nagase H
- Journal Title
  
  J. Med. Chem
  
  Volume: 58 Issue: 20 Pages: 7931-7937
- DOI
  10.1021/acs.jmedchem.5b00988
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-15K16557, KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-26220207
[Journal Article] Investigation of 7-benzylidenenaltrexone derivatives as a novel structural antitrichomonal lead compound2015
- Author(s)
  Kutsumura, N.; Nakajima, R.; Koyama, Y.; Miyata, Y.; Saitoh, T.; Yamamoto, N.; Iwata, S.; Fujii, H.; Nagase, H.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 25 Issue: 21 Pages: 4890-4892
- DOI
  10.1016/j.bmcl.2015.06.002
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16553, KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942
[Journal Article] Novel Delta Opioid Receptor Agonists with Oxazatricyclodecane Structure2014
- Author(s)
  Fujii, H.; Hayashida, K.; Saitoh, A.; Yokoyama, A.; Hirayama, S.; Iwai, T.; Nakata, E.; Nemoto, T.; Sudo, Y.; Uezono, Y.; Yamada, M.; Nagase, H
- Journal Title
  
  ACS Med. Chem. Lett
  
  Volume: 5 Issue: 4 Pages: 368-372
- DOI
  10.1021/ml400491k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590133, KAKENHI-PROJECT-24590740
[Journal Article] Essential Structure of the κ Opioid Receptor Agonist Nalfurafine for Binding to the κ Receptor2013
- Author(s)
  Nagase, H.; Fujii, H.
- Journal Title
  
  Curr. Pharmacuet. Des.
  
  Volume: 19 Issue: 42 Pages: 7400-7414
- DOI
  10.2174/138161281942140105165011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590133
[Journal Article] The effect of 17-N substituents on the activity of the opioid κ receptor in nalfurafine derivatives2013
- Author(s)
  Nemoto, T.; Hirayama, S.; Iwai, T.; Yamamoto, N.; Harada, Y.; Wada, N.; Tomatsu, M.; Ishihara, M.; Fujii, H.; Nagase, H.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 23 Issue: 1 Pages: 268-272
- DOI
  10.1016/j.bmcl.2012.10.100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590133
[Journal Article] Essential Structure of theκOpioid Receptor Agonist Nalfurafine for Binding to theκReceptor2013
- Author(s)
  Nagase, H.; Fujii, H
- Journal Title
  
  Curr. Pharmacuet. Des
  
  Volume: 19 Issue: 42 Pages: 7362-7372
- DOI
  10.2174/138161281942140105162601
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590133
[Journal Article] Essential Structure of Opioid κ Receptor Agonist Nalfurafine for Binding to κ Receptor 1: Synthesis of Decahydroisoquinoline Derivatives and Their Pharmacologies2012
- Author(s)
  Nagase H、Imaide S、Yamada T、Hirayama S、 Nemoto T、 Yamaotsu N、 Hirono S、 Fujii H
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 60 Issue: 8 Pages: 945-948
- DOI
  10.1248/cpb.c12-00336
- NAID
  130001852522
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590042, KAKENHI-PROJECT-23590133
[Journal Article] Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 2: Synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies2012
- Author(s)
  Nagase, H.; Imaide, S.; Hirayama, S.; Nemoto, T.; Fujii, H.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 22 Issue: 15 Pages: 5071-5074
- DOI
  10.1016/j.bmcl.2012.05.122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590133
[Journal Article] Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 3: Synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies2012
- Author(s)
  Fujii, H.; Imaide, S.; Hirayama, S.; Nemoto, T.; Gouda, H.; Hirono, S.; Nagase, H.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 22 Issue: 24 Pages: 7711-7714
- DOI
  10.1016/j.bmcl.2012.09.101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590133, KAKENHI-PROJECT-24590058
[Journal Article] Synthesis of a stable iminium salt and propellane derivatives2008
- Author(s)
  Nagase, H. ; Yamamot, N. ; Nemoto, T. ; Yoza, K. ; Kamiya, K. ; Hirono, S. ; Momen, S. ; Izumimoto, N. ; Hasebe, K. ; Mochizuki, H. ; Fujii, H.
- Journal Title
  
  J. Org. Chem. 73
  
  Pages: 8093-8096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590105
[Journal Article] Synthesis of a Stable Iminium Salt and Propellane Derivatives2008
- Author(s)
  Hiroshi Nagase
- Journal Title
  
  The Journal of Organic Chemistry 73
  
  Pages: 8093-8096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590105
[Journal Article] Novel cleavage reaction of the C16-N17 bond in naltrexone derivatives2008
- Author(s)
  Fujii, H. ; Imaide, S. ; Watanabe, A. ; Nemoto, T. ; Nagase, H.
- Journal Title
  
  Tetrahedron Lett 49
  
  Pages: 6293-6296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590105
[Journal Article] Synthesis of N-isobutylnoroxymorphone from naltrexone by a selective cyclopropane ring opening reaction2008
- Author(s)
  Fujii, H. ; Osa, Y. ; Ishihara, M. ; Hanamura, S. ; Nemoto, T. ; Nakajima, M. ; Hasebe, K. ; Mochizuki, H. ; Nagase, H.
- Journal Title
  
  Bioorg. Med. Chem. Lett. 18
  
  Pages: 4978-4981
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590105
[Patent] スルホンアミド誘導体またはその薬学的に許容される酸付加塩2017
- Inventor(s)
  長瀬博、斉藤毅、柳沢正史、入鹿山容子
- Industrial Property Rights Holder
  長瀬博、斉藤毅、柳沢正史、入鹿山容子
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Analysis of orexinergic function in chronic pain-like states2023
- Author(s)
  Kao Hashimoto, Yasuyuki Nagumo, Keita Iio, Yuki Saito, Yukiko Ishikawa, Noriki Kutsumura, Takeshi Sakurai, Masashi Yanagisawa, Tsuyoshi Saitoh, Hiroshi Nagase
- Organizer
  The 11th Annual WPI-IIIS Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] オレキシン1受容体を介する疼痛制御メカニズムの解析2023
- Author(s)
  橋本佳応、南雲康行、飯尾啓太、齊藤夕貴、石川有紀子、沓村憲樹、櫻井武、柳沢正史、斉藤毅、長瀬博
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] オレキシン1受容体選択的作動薬の設計と合成2023
- Author(s)
  長谷川大晟、飯尾啓太、石川有紀子、沓村憲樹、柳沢正史、長瀬博、斉藤毅
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] 配座制御に基づく新規テトラリン型OX2R選択的作動薬の創製2023
- Author(s)
  栗林利明、雨澤真櫻、岡田卓大、大下隆一郎、山本直司、南雲康行、沓村憲樹、入鹿山容子、石川有紀子、柳沢正史、長瀬博、斉藤毅
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] 選択的オレキシン１受容体作動薬の設計と合成2022
- Author(s)
  飯尾啓太、斉藤毅、橋本佳応、南雲康行、雨澤真櫻、長谷川大晟、石川有紀子、山本直司、沓村憲樹、柳沢正史、長瀬博
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] 2-メチルテトラリン誘導体を用いたオレキシン受容体作動薬の開発2022
- Author(s)
  雨澤真櫻、斉藤毅、岡田卓大、大下隆一郎、山本直司、南雲康行、沓村憲樹、入鹿山容子、石川有紀子、柳沢正史、長瀬博
- Organizer
  第66回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] TriMER骨格を用いたGPCRリガンド探索ツールの開発2022
- Author(s)
  雨澤真櫻、斉藤毅、山本直司、南雲康行、沓村憲樹、石川有紀子、柳沢正史、長瀬博
- Organizer
  第17回GPCR研究会
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] 1,3,5-Trioxazatriquinane骨格を用いたオレキシン受容体作動薬の創製2022
- Author(s)
  雨澤真櫻、斉藤毅、山本直司、南雲康行、沓村憲樹、石川有紀子、柳沢正史、長瀬博
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] Discovery of novel orexin receptor antagonists with 1,3,5-trioxazatriquinane skeleton2021
- Author(s)
  Mao Amezawa; Tsuyoshi Saitoh; Yukiko Ishikawa; Yoko Irukayama; Emi Hasegawa; Hiroaki Gouda; Naoshi Yamamoto; Noriki Kutsumura; Yasuyuki Nagumo; Sakurai Takeshi; Masashi Yanagisawa; Hiroshi Nagase
- Organizer
  The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem)(国際学会)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] Design and Synthesis of Novel Orexin Receptor Antagonists with 1,3,5-Trioxazatriquinane skeleton2021
- Author(s)
  Mao Amezawa; Jumpei Horiuchi; Tsuyoshi Saitoh; Ryuichiro Ohshita; Naoshi Yamamoto; Yasuyuki Nagumo; Yukiko Ishikawa; Yoko Irukayama; Emi Hasegawa; Noriki Kutsumura; Ryuji Tanimura; Sakurai Takeshi; Masashi Yanagisawa; Hiroshi Nagase
- Organizer
  AIMECS2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] Design and Synthesis of Novel Orexin Receptor Dual Agonists with Tetralin Skeleton2021
- Author(s)
  Keita Iio, Tsuyoshi Saitoh, Ryuichiro Ohshita, Tsubasa Hino, Mao Amezawa, Sayaka Ohrui, Takahiro Okada, Yasuyuki Nagumo, Naoshi Yamamoto, Yukiko Ishikawa, Yoko Irukayama-Tomobe, Noriki Kutsumura, Masashi Yanagisawa, Hiroshi Nagase
- Organizer
  AIMECS2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] モルヒナン骨格を基盤とする研究開発（独創的新薬の開発を目指して）2019
- Author(s)
  長瀬博
- Organizer
  日本薬学会中国四国支部　特別講演会
- Invited
- Data Source
  KAKENHI-ORGANIZER-15H05935
[Presentation] 世界初のOX2R作動薬YNT-185の創出とその薬理作用2019
- Author(s)
  長瀬博
- Organizer
  第13回日本緩和医療薬学会年会
- Invited
- Data Source
  KAKENHI-ORGANIZER-15H05935
[Presentation] モルヒナン骨格を基盤とする研究開発－独創的新薬の創出を目指して－2019
- Author(s)
  長瀬博
- Organizer
  有機合成化学協会関東支部ミニシンポジウム
- Invited
- Data Source
  KAKENHI-ORGANIZER-15H05935
[Presentation] 独創的新薬の開発を目指して2019
- Author(s)
  長瀬博
- Organizer
  東京理科大学大学院基礎工学研究科　招待講演
- Invited
- Data Source
  KAKENHI-ORGANIZER-15H05935
[Presentation] Design and synthesis of orexin receptor selective ligands and their pharmacology2019
- Author(s)
  Hiroshi Nagase
- Organizer
  Roman Pharmacists Association
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-15H05935
[Presentation] オレキシン受容体選択的リガンドの設計・合成とその薬理作用2019
- Author(s)
  長瀬博
- Organizer
  2019年度東北医科薬科大学創薬研究センターシンポジウム
- Invited
- Data Source
  KAKENHI-ORGANIZER-15H05935
[Presentation] Discovery of Novel Orexin Receptor Antagonist with 1,3,5-Trioxazatriquinane Skeleton2019
- Author(s)
  Mao Amezawa, Jumpei Horiuchi, Tsuyoshi Saitoh, Yasuhiro Ogawa, Yukiko Ishikawa, Yoko Irukayama, Emi Hasegawa, Daichi Hayakawa, Yurie Watanabe, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Hiroaki Gouda, Takeshi Sakurai, Masashi Yanagisawa, Hiroshi Nagase
- Organizer
  The 27th French-Japanese Symposium on Medicinal and Fine Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-15H05935
[Presentation] Essential structure of orexin 1 receptor antagonist YNT-7072019
- Author(s)
  Sayaka Ohrui, Naoshi Yamamoto, Takahiro Okada, Masahiro Yata, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Yurie Watanabe, Daichi Hayakawa, Hiroaki Gouda, Masashi Yanagisawa, *Hiroshi Nagase
- Organizer
  27th International Society of Heterocyclic Chemistry Congress
- Data Source
  KAKENHI-ORGANIZER-15H05935
[Presentation] Design and synthesis of orexin receptor selective ligands and their pharmacology2019
- Author(s)
  H. Nagase,
- Organizer
  Roman Pharmacists Association
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05942
[Presentation] Design and synthesis of orexin receptor selective ligands and their pharmacology2019
- Author(s)
  Hiroshi Nagase
- Organizer
  Novel Pain Therapeutics: From Basic Research to Clinical Translation and Rehabilitation
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-15H05935
[Presentation] 難治性掻痒症治療薬ナルフラフィンの研究・開発とオレキシン受容体拮抗薬の設計・合成2019
- Author(s)
  長瀬博
- Organizer
  富山大学大学院生命融合科学教育部　特別講演会
- Invited
- Data Source
  KAKENHI-ORGANIZER-15H05935
[Presentation] Development of photocaged adenosine2A receptor activator,2018
- Author(s)
  Tsuyoshi Saitoh, Shuji Ioka, Mustafa Korkutata, Yohei Chitose, Manabu Abe, Michael Lazarus, and Hiroshi Nagase
- Organizer
  The 13th International Symposium on Organic Reactions
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05942
[Presentation] 睡眠・覚醒の謎に挑む～睡眠病の治療薬を目指して～2018
- Author(s)
  長瀬　博
- Organizer
  くすりと健康2018春季講演会（日本薬学会関東支部・市民講座）
- Invited
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] オレキシン受容体選択的リガンドの設計・合成2018
- Author(s)
  長瀬博
- Organizer
  第40回白金シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] 1,3,5-Trioxazatriquinane骨格を有するトリマーの合成とオレキシン受容体拮抗活性評価2018
- Author(s)
  雨澤真櫻、堀内惇平、斉藤　毅、大下隆一郎、小川靖裕、石川有紀子、入鹿山容子、長谷川恵美、南雲康行、山本直司、沓村憲樹、早川大地、渡邉友里江、合田浩明、櫻井　武、柳沢正史、長瀬　博
- Organizer
  第62回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Design and synthesis of orexin receptor selective ligands2017
- Author(s)
  Nagase H
- Organizer
  26th French-Japanese Symposium on Medicinal and Fine Chemistry
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05942
[Presentation] Design and synthesis of orexin receptor selective ligands2017
- Author(s)
  Nagase H
- Organizer
  26th French-Japanese Symposium on Medicinal and Fine Chemistry
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-15H05935
[Presentation] オレキシンリガンドの探索研究2017
- Author(s)
  長瀬博
- Organizer
  北海道大学大学院生命科学院　特別講義
- Invited
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] 低分子量オレキシン受容体2型作動薬YNT-185の組織学的、及び電気生理学的解析2017
- Author(s)
  小川　靖裕、入鹿山　容子、富永　拡、細川　直人、斉藤　毅、長瀬　博、柳沢　正史
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎新聞文化ホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] トリマーリガンドの合成とその薬理作用2017
- Author(s)
  長瀬博
- Organizer
  全薬工業株式会社　特別講演
- Invited
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] キャップトリマー骨格を有するオレキシン受容体拮抗薬の設計・合成12017
- Author(s)
  堀内惇平、大下隆一郎、南雲康行、山本直司、沓村憲樹、斉藤毅、入鹿山容子、石川有紀子、小川靖裕、柳沢正史、長瀬博
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] オレキシン高発現マウスにおける心筋梗塞の予後改善2017
- Author(s)
  石川　ゆい、村越　伸行、入鹿山　容子、小川　靖裕、内田　俊太郎、富永　拡、田尻　和子、長瀬　博、柳沢　正史
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎新聞文化ホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] オレキシン１受容体拮抗薬YNT-707の必須構造部位検討2017
- Author(s)
  大類彩、山本直司、岡田卓大、谷田誠浩、斉藤毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、渡邊友里恵、早川大地、合田浩明、柳沢正史、長瀬博
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] キャップトリマー骨格を有するオレキシン受容体拮抗薬の設計・合成22017
- Author(s)
  大下隆一郎、堀内惇平、南雲康行、山本直司、沓村憲樹、斉藤毅、入鹿山容子、石川有紀子、小川靖裕、柳沢正史、長瀬博
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] モルヒナン骨格を有するオレキシン1受容体（OX1R）の特異的拮抗薬の設計・合成とOX1R結合の活性立体配座2017
- Author(s)
  山本直司、大類彩、岡田卓大、谷田誠浩、斉藤毅、沓村憲樹、南雲康行、入鹿山容子、小川靖裕、石川有紀子、平山重人、渡辺友里恵、早川大地、合田浩明、柳沢正史、長瀬博
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Design and synthesis of orexin 1 receptor selective antagonists2017
- Author(s)
  Sayaka Ohrui, Naoshi Yamamoto, Masahiro Yata, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Shigeto Hirayama, Masashi Yanagisawa, Hiroshi Nagase
- Organizer
  Tsukuba Global Science Week (TGSW) 2017
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] 新規低分子量オレキシン受容体作動薬YNT-185の全身炎症後の活動回復作用の検討2017
- Author(s)
  内田　俊太郎、入鹿山　容子、小川　靖裕、富永　拡、石川　ゆい、木山　麻衣子、斉藤　毅、長瀬　博、柳沢　正史
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎新聞文化ホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Design and synthesis of orexin receptor selective ligands2017
- Author(s)
  Hiroshi Nagase
- Organizer
  26th French-Japanese Symposium on Medicinal and Fine Chemistry
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] 低分子オレキシン受容体アゴニストの創製2016
- Author(s)
  斉藤　毅、永原崇志、沓村憲樹、入鹿山容子、小川靖裕、富永　拡、黒田大介、合田浩明、藤井秀明、柳沢正史、長瀬　博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Invited
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Synthesis of Novel, Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton2016
- Author(s)
  Naoshi Yamamoto, Masahiro Yata, Sayaka Ohrui, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Daisuke Kuroda, Hiroaki Gouda, Masashi Yanagisawa, Hiroshi Nagase
- Organizer
  The 25th French-Japanese Symposium on Medicinal and Fine Chemistry
- Place of Presentation
  Keio Plaza Hotel Tama（東京都多摩市）
- Year and Date
  2016-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] モルヒナン骨格を有する新規オレキシン1受容体選択的拮抗薬の設計・合成①2016
- Author(s)
  大類　彩、山本直司、谷田誠浩、岡田卓大、斉藤　毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、柳沢正史、長瀬　博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] ナルフラフィンの構造を基にしたオレキシン1受容体選択的拮抗薬の設計・合成およびその薬理作用2016
- Author(s)
  山本直司、谷田誠浩、大類　彩、岡田卓大、斉藤　毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、平山重人、柳沢正史、長瀬　博
- Organizer
  第36回鎮痛薬・オピオイドペプチドシンポジウム
- Place of Presentation
  北海道大学（北海道札幌市）
- Year and Date
  2016-06-19
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] YNT-707のOX1Rアンタゴニスト活性発現のための必須構造の検討2016
- Author(s)
  関　知範、中嶋　龍、斉藤　毅、入鹿山容子、小川靖裕、石川有紀子、柳沢正史、長瀬　博
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] モルヒナン骨格を有する新規オレキシン1受容体選択的拮抗薬の設計・合成②2016
- Author(s)
  岡田卓大、山本直司、谷田誠浩、大類　彩、斉藤　毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、平山重人、柳沢正史、長瀬　博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] オレキシン2受容体作動薬の設計・合成2016
- Author(s)
  長瀬　博、永原　崇志、斉藤　毅、沓村　憲樹、入鹿山　容子、小川　靖裕、黒田　大祐、合田　浩明、藤井　秀明、柳沢　正史
- Organizer
  第36回鎮痛薬・オピオイドペプチドシンポジウム
- Place of Presentation
  北海道大学（北海道札幌市）
- Year and Date
  2016-08-19
- Invited
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] オレキシン受容体作動薬：創薬への展望2016
- Author(s)
  長瀬博
- Organizer
  日本睡眠学会第41回定期学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-ORGANIZER-15H05935
[Presentation] YNT-707のOX1R拮抗作用発現のための必須構造の検討2016
- Author(s)
  関　知範、中嶋　龍、斉藤　毅、入鹿山容子、小川靖裕、石川有紀子、柳沢正史、長瀬　博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] オレキシン２受容体作動薬YNT-185の創製2016
- Author(s)
  斉藤　毅、永原崇志、沓村憲樹、中嶋　龍、細川直人、入鹿山容子、小川靖裕、富永　拡、黒田大介、合田浩明、藤井秀明、柳沢正史、長瀬　博
- Organizer
  第34回メディシナルケミストリーシンポジウム　サテライトセッション
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] モルヒナン骨格を有するオレキシン１受容体選択的拮抗薬の設計・合成とその薬理作用”2016
- Author(s)
  大類　彩、山本直司、谷田誠浩、岡田卓大、斉藤　毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、平山重人、柳沢正史、長瀬　博
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Design and Synthesis of Orexin 2 Receptor Agonists2016
- Author(s)
  Hiroshi Nagase
- Organizer
  Tsukuba Global Science Week 2016
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-09-19
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Design and synthesis of novel ligands of opioid receptors2015
- Author(s)
  Hiroshi. Nagase
- Organizer
  Pacifichem 2015
- Place of Presentation
  ヒルトンハワイアンヴィレッジ（アメリカ、ハワイ、ホノルル）
- Year and Date
  2015-12-17
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05942
[Presentation] DESIGN AND SYNTHESIS OF NOVEL δ OPIOID AGONISTS AND THEIR PHARMACOLOGIES2015
- Author(s)
  Hiroshi. Nagase
- Organizer
  Drug Discovery & Therapy World Congress 2015
- Place of Presentation
  カインズコンベンションセンター（アメリカ、マサチューセッツ、ボストン）
- Year and Date
  2015-07-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05942
[Presentation] Design and synthesis of novel delta opioid agonists and their pharmacologies2015
- Author(s)
  Nagase H
- Organizer
  Drug Discovery & Therapy World Congress
- Place of Presentation
  Boston, MA, USA
- Year and Date
  2015-07-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-15H05935
[Presentation] Design and synthesis of novel ligands of opioid receptors2015
- Author(s)
  Nagase H
- Organizer
  Pacifichem
- Place of Presentation
  Honolulu, HI, USA
- Year and Date
  2015-12-17
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-15H05935
[Presentation] CellKeyTMシステムを用いた作動活性評価とそれに基づく選択的オピオイドκ受容体作動薬ナルフラフィンの必須構造の検討2014
- Author(s)
  藤井秀明、今出慧海、横山明信、須藤結香、平山重人、岩井孝志、山田貴明、根本　徹、上園保仁、長瀬　博
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23590133
[Presentation] CellKey^<TM>システムを用いた作動活性評価とそれに基づく選択的オピオイドκ受容体作動薬ナルフラフィンの必須構造の検討2014
- Author(s)
  藤井秀明、今出慧海、横山明信、須藤結香、平山重人、岩井孝志、山田貴明、根本徹、上園保仁、長瀬博
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Year and Date
  2014-03-28
- Data Source
  KAKENHI-PROJECT-23590133
[Presentation] オキサアザトリシクロデカン骨格を有する新規オピオイドδ受容体作動薬の設計と合成、およびその薬理作用22013
- Author(s)
  藤井秀明、林田康平、渡邉義一、齊藤大祐、高橋俊弘、酒井潤一、田中恵理子、神田貴史、岩井孝志、平山重人、根本徹、山川富雄、長瀬博
- Organizer
  第33回鎮痛薬・オピオイドペプチドシンポジウム
- Place of Presentation
  神戸
- Year and Date
  2013-09-07
- Data Source
  KAKENHI-PROJECT-23590133
[Presentation] オキサアザトリシクロデカン骨格を有する新規オピオイドδ受容体作動薬の設計と合成、およびその薬理作用２2013
- Author(s)
  藤井秀明、林田康平、渡邉義一、齊藤大祐、高橋俊弘、酒井潤一、田中恵理子、神田貴史、岩井孝志、平山重人、根本　徹、山川富雄、長瀬　博
- Organizer
  第33回鎮痛薬・オピオイドペプチドシンポジウム
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590133
[Presentation] CellKey™ systemを用いた新規δオピオイド受容体特異的アゴニストの開発及びスクリーニング2013
- Author(s)
  横山明信、須藤結香、宮野加奈子、鈴木雅美、白石成二、平山重人、林田康平、藤井秀明、酒井潤一、神田貴史、中田恵理子、長瀬博、樋上賀一、上園保仁
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23590133
[Presentation] CellKey™systemを用いた新規δオピオイド受容体特異的アゴニストの開発及びスクリーニング2013
- Author(s)
  横山明信、須藤結香、宮野加奈子、鈴木雅美、白石成二、平山重人、林田康平、藤井秀明、酒井潤一、神田貴史、中田恵理子、長瀬博、樋上賀一、上園保仁
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Year and Date
  2013-03-22
- Data Source
  KAKENHI-PROJECT-23590133
[Presentation] オキサアザトリシクロデカン骨格を有する新規オピオイドδ受容体作動薬の設計と合成、およびその薬理作用2012
- Author(s)
  藤井秀明、林田康平、平山重人、岩井孝志、根本徹、酒井潤一、神田貴史、中田理恵子、上園保仁、長瀬博
- Organizer
  第32回鎮痛薬・オピオイドペプチドシンポジウム
- Place of Presentation
  東京
- Year and Date
  2012-09-16
- Data Source
  KAKENHI-PROJECT-23590133
[Presentation] 17-置換モルヒナン誘導体の合成と薬理作用2008
- Author(s)
  藤井秀明、花村新一、山本直司、石原茉莉菜、長由美子、木綿しのぶ、長谷部光、望月英典、長瀬博
- Organizer
  第29回鎮痛薬・オピオイドペプチドシンポジウム
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-19590105
[Presentation] ナルトレキソン16-17位の新規切断反応を用いたオピオイド受容体リガンドの合成2007
- Author(s)
  今出慧海、渡辺晃生、藤井秀明、長瀬博
- Organizer
  第33回反応と合成の進歩シンポジウム
- Place of Presentation
  長崎ブリックホール
- Year and Date
  2007-11-06
- Data Source
  KAKENHI-PROJECT-19590105
[Presentation] PtO_2を用いるN-シクロプロピルメチル基の還元的開裂反応2007
- Author(s)
  花村新一、石原茉莉菜、長由美子、藤井秀明、長瀬博
- Organizer
  第37回複素環化学討論会
- Place of Presentation
  長野市若里市民文化ホール
- Year and Date
  2007-10-18
- Data Source
  KAKENHI-PROJECT-19590105
[Presentation] ナルトレキソン16-17位の新規切断反応を用いたオピオイド受容体リガンドの合成2007
- Author(s)
  今出慧海、渡邊晃生、藤井秀明、長瀬博
- Organizer
  第51回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2007-10-06
- Data Source
  KAKENHI-PROJECT-19590105
[Presentation] ナルトレキソン16-17位の新規切断反応を用いたオピオイド受容体リガンドの合成2007
- Author(s)
  今出慧海、渡辺晃生、藤井秀明、長瀬博
- Organizer
  第51回日本薬学会関東支部大会
- Place of Presentation
  星薬科大学
- Year and Date
  2007-10-06
- Data Source
  KAKENHI-PROJECT-19590105
[Presentation] Synthesis of a novel opioid compound by rearrangement of morphine skeleton2007
- Author(s)
  Yamamoto, N. ; Nagase, H.
- Organizer
  19^<th> French-Japanese Synposium on Medicinal and Fine Chemistry
- Place of Presentation
  Toyama
- Year and Date
  2007-05-14
- Data Source
  KAKENHI-PROJECT-19590105
[Presentation] PtO_2を用いるN-シクロプロピルメチル基の還元的開環反応2007
- Author(s)
  花村新一、石原茉莉菜、長由美子、藤井秀明、長瀬博
- Organizer
  第37回複素環討論会
- Place of Presentation
  長野
- Data Source
  KAKENHI-PROJECT-19590105
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# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 塩田清二

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# of Collaborated Products: 1 results
37. 竹ノ谷文子

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# of Collaborated Products: 1 results
38. 亀井淳三

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# of Collaborated Products: 1 results
39. 熊谷英敏

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# of Collaborated Products: 1 results

Nagase Hiroshi 長瀬 博

NAGASE Hiroshi 長瀬 博

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Development of novel selective orexin 1 receptor agonists and elucidation of the function of orexin receptorsPrincipal Investigator

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Development of novel orexin ligand and its pharmacological activityPrincipal Investigator

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Integral Understanding of Life-regulation Mechanism from "SPACE"

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Development of a new sleep-wake control method for super stress environment, SpacePrincipal Investigator

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Investigation of the relationship between opioid kappa receptor subtype and receptor dimerization

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Investigation of binding sites of agonists or antagonists on opioid receptor ligandsPrincipal Investigator

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[Book] アルカロイドの科学2016

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[Book] Arch Pharm Chem Life Sci「Synthesis of novel triplets with a 1,3,5-trioxazatriquinane skeleton and their pharmacologies for opioid receptors」2015

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[Book] 平成27年度日本薬学会医薬化学部会賞を受賞し、Med Chem Newsに掲載「低分子オレキシン受容体アゴニストの創製」2015

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[Journal Article] Design and synthesis of novel orexin 2 receptor agonists with a 1,3,5-trioxazatriquinane skeleton2023

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[Journal Article] Design and Synthesis of Orexin 1 Receptor-Selective Agonists2023

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[Journal Article] Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring2022

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[Journal Article] Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton2022

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[Journal Article] Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) librasy2022

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Nagase Hiroshi 長瀬博

NAGASE Hiroshi 長瀬博

[Journal Article] IIIS発　ナルコレプシー治療薬開発に向けた取り組み2017