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Nagase Hiroshi  長瀬 博

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NAGASE Hiroshi  長瀬 博

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Researcher Number 70383651
Other IDs
Affiliation (Current) 2021: 筑波大学, 国際統合睡眠医科学研究機構, 教授
Affiliation (based on the past Project Information) *help 2015 – 2020: 筑波大学, 国際統合睡眠医科学研究機構, 教授
2018: 筑波大学, 国際統合睡眠医科学研究機構, 特命教授
2015: 筑波大学, 学内共同利用施設等, 教授
2013: 筑波大学, 国際統合睡眠医科学研究機構, 教授
2007 – 2008: Kitasato University, 薬学部, 教授
Review Section/Research Field
Principal Investigator
Drug development chemistry / Complex systems / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Except Principal Investigator
Drug development chemistry / Complex systems
Keywords
Principal Investigator
作動薬 / オピオイド / 拮抗薬 / 睡眠 / オレキシン / 生物活性物質 / 医薬分子設計 / 睡眠診断法 / 不眠症治療薬 / 宇宙飛行士 … More / 睡眠覚醒制御遺伝子 / オレキシン受容体作動薬 / ストレス / モルヒナン / 創薬化学 / 有機合成化学 / ナルフラフィン / オレキシン受容体 / 覚醒 / ナルコレプシー / オレキシン1受容体 / 薬理評価 / 機能解明 … More
Except Principal Investigator
医薬分子設計 / 受容体ダイマー / オピオイド / κ作動薬 / ファーマコフォー / 特殊環境 / 社会医学 / ストレス / 微小重力 / 放射線 / 宇宙 / 無重力 / 微生物 Less
  • Research Projects

    (6 results)
  • Research Products

    (91 results)
  • Co-Researchers

    (48 People)
  •  Development of novel selective orexin 1 receptor agonists and elucidation of the function of orexin receptorsPrincipal InvestigatorOngoing

    • Principal Investigator
      長瀬 博
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
    • Research Institution
      University of Tsukuba
  •  Development of novel orexin ligand and its pharmacological activityPrincipal Investigator

    • Principal Investigator
      Nagase Hiroshi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      University of Tsukuba
  •  宇宙からひも解く新たな生命制御機構の統合的理解Ongoing

    • Principal Investigator
      古川 聡
    • Project Period (FY)
      2015 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      Japan Aerospace EXploration Agency
  •  Development of a new sleep-wake control method for super stress environment, SpacePrincipal Investigator

    • Principal Investigator
      Nagase Hiroshi
    • Project Period (FY)
      2015 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      University of Tsukuba
  •  Investigation of the relationship between opioid kappa receptor subtype and receptor dimerization

    • Principal Investigator
      FUJII Hideaki
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      Kitasato University
  •  Investigation of binding sites of agonists or antagonists on opioid receptor ligandsPrincipal Investigator

    • Principal Investigator
      NAGASE Hiroshi
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      Kitasato University

All 2019 2018 2017 2016 2015 2014 2013 2012 2008 2007

All Journal Article Presentation Book Patent

  • [Book] アルカロイドの科学2016

    • Author(s)
      長瀬 博, 沓村 憲樹
    • Publisher
      化学同人
    • Data Source
      KAKENHI-PLANNED-15H05942
  • [Book] Arch Pharm Chem Life Sci「Synthesis of novel triplets with a 1,3,5-trioxazatriquinane skeleton and their pharmacologies for opioid receptors」2015

    • Author(s)
      Nagase H, Katsunuma N
    • Total Pages
      15
    • Publisher
      Wiley
    • Data Source
      KAKENHI-ORGANIZER-15H05935
  • [Book] 平成27年度日本薬学会医薬化学部会賞を受賞し、Med Chem Newsに掲載「低分子オレキシン受容体アゴニストの創製」2015

    • Author(s)
      斉藤毅、長瀬博
    • Total Pages
      7
    • Publisher
      日本薬学会
    • Data Source
      KAKENHI-ORGANIZER-15H05935
  • [Journal Article] Enhancing endogenous adenosine A2A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function2019

    • Author(s)
      Korkutata M, Saitoh T, Cherasse Y, Ioka S, Duo F, Qin R, Murakoshi N, Fujii S, Zhou X, Sugiyama F, Chen JF, Kumagai H, Nagase H, Lazarus M
    • Journal Title

      Neuropharmacology

      Volume: 144 Pages: 122-132

    • DOI

      10.1016/j.neuropharm.2018.10.022

    • NAID

      120006583051

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PUBLICLY-18H04966, KAKENHI-PROJECT-17H02215
  • [Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity2018

    • Author(s)
      Ohrui Sayaka、Yamamoto Naoshi、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 28 Pages: 774-777

    • DOI

      10.1016/j.bmcl.2017.12.069

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06095, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-15K16557, KAKENHI-PROJECT-16H05098
  • [Journal Article] Synthesis of novel 1,3-dioxa-5-thiazatriquinane and 1-oxa-3,5-dithiazatriquinane derivatives and their pharmacologies2018

    • Author(s)
      Ohshita R, Kutsumura N, and Nagase H, et al
    • Journal Title

      Heterocycles

      Volume: 97 Pages: 687-695

    • DOI

      10.3987/com-18-s(t)40

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942
  • [Journal Article] 宇宙環境における睡眠問題の解決2018

    • Author(s)
      長瀬博、北川博之、船戸弘正、阿部高志、小久保利雄
    • Journal Title

      生体の科学

      Volume: 69 Pages: 138-141

    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Journal Article] オレキシン受容体を標的としたナルコレプシー治療薬の開発2018

    • Author(s)
      斉藤毅、長瀬博
    • Journal Title

      バイオサイエンスとインダストリー(B&I)

      Volume: 76 Pages: 127-129

    • NAID

      40021512201

    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Journal Article] Acetic anhydride mediated retro-ene reaction via a [4.4.3]propellane skeleton intermediate containing a quaternary ammonium linkage2018

    • Author(s)
      Kutsumura N, Okada T, Imaide S, Fujii H, and Nagase H*
    • Journal Title

      Synthesis

      Volume: 50 Pages: 4263-4269

    • DOI

      10.1055/s-0036-1589138

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-15H05942
  • [Journal Article] Design and synthesis of potent and highly selective orexin 1 receptor antagonists with a morphinan skeleton and their pharmacologies.2017

    • Author(s)
      Nagase H and Yanagisawa M et al.
    • Journal Title

      Journal of Medicinal Chemistory

      Volume: 60 Pages: 1018-1040

    • DOI

      10.1021/acs.jmedchem.6b01418

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-ORGANIZER-15H05935, KAKENHI-PROJECT-26220207, KAKENHI-PROJECT-16H05098, KAKENHI-PROJECT-15H06606, KAKENHI-PROJECT-15K19195
  • [Journal Article] The application of a specific morphinan template to the synthesis of galanthamine2017

    • Author(s)
      Yamamoto Naoshi、Okada Takahiro、Harada Yukimasa、Kutsumura Noriki、Imaide Satomi、Saitoh Tsuyoshi、Fujii Hideaki、Nagase Hiroshi
    • Journal Title

      Tetrahedron

      Volume: 73 Pages: 5751-5758

    • DOI

      10.1016/j.tet.2017.08.014

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Journal Article] Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models2017

    • Author(s)
      Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M.
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 114 Pages: 5731-5736

    • DOI

      10.1073/pnas.1700499114

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-16H06400, KAKENHI-PROJECT-15H03122, KAKENHI-PROJECT-15K16557, KAKENHI-PROJECT-16H05098
  • [Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor2017

    • Author(s)
      Yamamoto Naoshi、Ohrui Sayaka、Okada Takahiro、Yata Masahiro、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
    • Journal Title

      Bioorganic & medicinal chemistry letters

      Volume: 27 Pages: 4176-4179

    • DOI

      10.1016/j.bmcl.2017.07.011

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-15K16557, KAKENHI-PROJECT-16H05098
  • [Journal Article] IIIS発 ナルコレプシー治療薬開発に向けた取り組み2017

    • Author(s)
      斉藤毅、入鹿山容子、柳沢正史、長瀬博
    • Journal Title

      なるこ

      Volume: 34 Pages: 8-10

    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Journal Article] 24.Nagase H., N. Yamamoto, and M. Yanagisawa et al. Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies2016

    • Author(s)
      Nagase H., N. Yamamoto, and M. Yanagisawa et al.
    • Journal Title

      J. Med. Chem.

      Volume: 60 Pages: 1018-1040

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-15H05942
  • [Journal Article] Opioid System in the Lateral Hypothalamus Regulate Feeding Behavior Through Orexin and GABA Neurons2016

    • Author(s)
      Ardianto C, Yonemochi N, Yamamoto S, Yang L, Takenoya F, Shioda S, Nagase H, Ikeda H, Kamei J.
    • Journal Title

      NeuroScience

      Volume: 320 Pages: 183-193

    • DOI

      10.1016/j.neuroscience.2016.02.002

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26350912, KAKENHI-PROJECT-26430024, KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-23249079, KAKENHI-PROJECT-16H02684, KAKENHI-PROJECT-15K15670
  • [Journal Article] オレキシンの神経科学と創薬2016

    • Author(s)
      櫻井 武, 長瀬 博
    • Journal Title

      MEDCHEM NEW

      Volume: 26 Pages: 170-175

    • NAID

      130006510952

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Journal Article] 難治性掻痒症治療薬 ナルフラフィンの研究開発2016

    • Author(s)
      長瀬 博, 沓村 憲樹
    • Journal Title

      SAR News

      Volume: 30 Pages: 2-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-15H05942
  • [Journal Article] 低分子オレキシン受容体アゴニストの創製2016

    • Author(s)
      斉藤毅, 長瀬博
    • Journal Title

      MedChem News

      Volume: 26(2) Pages: 90-96

    • NAID

      130007383316

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-15H05942
  • [Journal Article] Intrathecal morphine-3-glucuronide-induced nociceptive behavior via Delta-2 opioid receptors in the spinal cord2016

    • Author(s)
      Takaaki Komatsu, Soh Katsuyama, Hiroshi Nagase, Hirokazu Mizoguchi, Chikai Sakurada, Minoru Tsuzuki, Shinobu Sakurada, Tsukasa Sakurada
    • Journal Title

      Pharmacol. Biochem. Be.

      Volume: 140 Pages: 68-74

    • DOI

      10.1016/j.pbb.2015.10.010

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08678, KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-25460725
  • [Journal Article] 低分子オレキシン受容体アゴニストの創製2016

    • Author(s)
      斉藤 毅,長瀬 博
    • Journal Title

      MEDCHEM NEWS

      Volume: 26 Pages: 90-96

    • NAID

      130007383316

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Journal Article] 睡眠覚醒を制御する世界初の分子:オレキシン2受容体作動薬YNT-185の創製2016

    • Author(s)
      斉藤 毅,長瀬 博
    • Journal Title

      和光純薬時報

      Volume: 84 Pages: 2-5

    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Journal Article] 内因性オピオイドの痒みへの関与と痒み調節機構の解明2016

    • Author(s)
      長瀬 博, 沓村 憲樹
    • Journal Title

      JOHNS

      Volume: 32 Pages: 564-567

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-15H05942
  • [Journal Article] ナルフラフィン塩酸塩2015

    • Author(s)
      長瀬 博
    • Journal Title

      メディカル朝日[特集]混合ワクチン最前線 サムライたちのクスリPart II「ニッポン発の創薬」を目指して(12)

      Volume: 7 Pages: 66-69

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-15H05942
  • [Journal Article] Naltrindole derivatives with fluorinated ethyl substituents on 17-nitrogen as delta opioid receptor inverse agonist2015

    • Author(s)
      Nemoto T, Iihara Y, Hirayama S, Iwai T, Higashi E, Fujii H, Nagase H
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 25 Pages: 2927-30

    • DOI

      10.1016/j.bmcl.2015.05.038

    • Peer Reviewed
    • Data Source
      KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935
  • [Journal Article] Inhibition of opioid systems in the hypothalamus as well as the mesolimbic area suppresses feeding behavior of mice2015

    • Author(s)
      Ikeda H, Ardianto C, Yonemochi N, Yang L, Ohashi T, Ikegami M, Nagase H, Kamei J
    • Journal Title

      NeuroScience

      Volume: 311 Pages: 9-21

    • DOI

      10.1016/j.neuroscience.2015.10.002

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26430024, KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942
  • [Journal Article] 難治性そう痒症治療薬レミッチ®カプセルの創出2015

    • Author(s)
      長瀬 博
    • Journal Title

      医薬の門

      Volume: 54 Pages: 20-24

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-15H05942
  • [Journal Article] Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain2015

    • Author(s)
      Nakajima R, Yamamoto N, Hirayama S, Iwai T, Saitoh A, Nagumo Y, Fujii H, Nagase H.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 23 Pages: 6271-6279

    • DOI

      10.1016/j.bmc.2015.08.036

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19195, KAKENHI-PROJECT-26860076, KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-15J03517
  • [Journal Article] Design and synthesis of non-peptide, selective orexin receptor 2 agonists2015

    • Author(s)
      Nagahara T, Saitoh T, Kutsumura N, Irukayama-Tomobe Y, Ogawa Y, Kuroda D, Gouda H, Kumagai H, Fujii H, Yanagisawa M, Nagase H
    • Journal Title

      J Med Chem.

      Volume: 58 Pages: 7931-37

    • DOI

      10.1021/acs.jmedchem.5b00988

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-15K16557, KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-26220207
  • [Journal Article] Naltrindole derivatives with fluorinated ethyl substituents on 17-nitrogen as δ opioid receptor inverse agonist2015

    • Author(s)
      Kutsumura, N.; Nakajima, R.; Koyama, Y.; Miyata, Y.; Saitoh, T.; Yamamoto, N.; Iwata, S.; Fujii, H.; Nagase, H.
    • Journal Title

      Bioorg. Med. Chem. Lett

      Volume: 25 Pages: 4890-2

    • DOI

      10.1016/j.bmcl.2015.06.002

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K16553, KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942
  • [Journal Article] Synthesis of Novel Triplets with a 1,3,5-Trioxazatriquinane Skeleton and their Pharmacologies for Opioid Receptors2015

    • Author(s)
      H. Nagase, N. Kutsumura
    • Journal Title

      Arch. Pharm. Chem. Life Sci.

      Volume: 348 Pages: 375-389

    • DOI

      10.1002/ardp.201500031

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-15H05942
  • [Journal Article] Transformation of naltrexone into mesembrane and investigation of the binding properties of its intermediate derivatives to opioid receptors2015

    • Author(s)
      Konoura K, Fujii H, Imaide S, Gouda H, Hirayama S, Hirono S, Nagase H
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 23 Pages: 439-448

    • DOI

      10.1016/j.bmc.2014.12.032

    • NAID

      120005555623

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942
  • [Journal Article] Peripheral opioid antagonist enhances the effect of anti-tumor drug by blocking a cell growth-suppressive pathway in vivo.2015

    • Author(s)
      Masami Suzuki, Fumiko Chiwaki, Yumi Sawada, Maho Ashikawa, Kazuhiko Aoyagi, Takeshi Fujita, Kazuyoshi Yanagihara, Masayuki Komatsu, Minoru Narita, Tsutomu Suzuki, Hiroshi Nagase, Ryoji Kushima, Hiromi Sakamoto, Takeo Fukagawa, Hitoshi Katai, Hitoshi Nakagama, Teruhiko Yoshida, Yasuhito Uezono, Hiroki Sasaki
    • Journal Title

      PLoS One.

      Volume: 10(4) Pages: 1-18

    • DOI

      10.1371/journal.pone.0123407

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25860432, KAKENHI-PROJECT-26640015, KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-26293346
  • [Journal Article] Novel delta opioid receptor agonists with oxazatricyclodecane structure.2014

    • Author(s)
      Fujii, H.; Hayashida, K.; Saitoh, A.; Yokoyama, A.; Hirayama, S.; Iwai, T.; Nakata, E.; Nemoto, T.; Sudo, Y.; Uezono, Y.; Yamada, M.; Nagase, H
    • Journal Title

      ACS Med Chem Lett

      Volume: 5 Pages: 368-372

    • DOI

      10.1021/ml400491k

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590133, KAKENHI-PROJECT-24590740
  • [Journal Article] The effect of 17-N substituents on the activity of the opioidκreceptor in nalfurafine derivatives2013

    • Author(s)
      Nemoto, T.; Hirayama, S.; Iwai, T.; Yamamoto, N.; Harada, Y.; Wada, N.; Tomatsu, M.; Ishihara, M.; Fujii, H.; Nagase, H.
    • Journal Title

      Bioorg. Med. Chem. Lett

      Volume: 23 Pages: 268-272

    • DOI

      10.1016/j.bmcl.2012.10.100

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590133
  • [Journal Article] Essential Structure of the κ Opioid Receptor Agonist Nalfurafine for Binding to the κ Receptor2013

    • Author(s)
      Nagase, H.; Fujii, H.
    • Journal Title

      Curr. Pharmacuet. Des.

      Volume: 19 Pages: 7400-7414

    • DOI

      10.2174/138161281942140105165011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590133
  • [Journal Article] Essential Structure of theκOpioid Receptor Agonist Nalfurafine for Binding to theκReceptor2013

    • Author(s)
      Nagase, H.; Fujii, H
    • Journal Title

      Curr. Pharmacuet. Des

      Volume: 19

    • DOI

      10.2174/138161281942140105162601

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590133
  • [Journal Article] Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 3: Synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies.2012

    • Author(s)
      Fujii, H.; Imaide, S.; Hirayama, S.; Nemoto, T.; Gouda, H.; Hirono, S.; Nagase, H.
    • Journal Title

      Bioorg. Med. Chem. Lett

      Volume: 22 Pages: 7711-7714

    • DOI

      10.1016/j.bmcl.2012.09.101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590133, KAKENHI-PROJECT-24590058
  • [Journal Article] Essential structure of opioidκreceptor agonist nalfurafine for binding to theκreceptor 2: Synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies2012

    • Author(s)
      Nagase, H.; Imaide, S.; Hirayama, S.; Nemoto, T.; Fujii, H.
    • Journal Title

      Bioorg. Med. Chem. Lett

      Volume: 22 Pages: 5071-5074

    • DOI

      10.1016/j.bmcl.2012.05.122

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590133
  • [Journal Article] Essential Structure of Opioid κ Receptor Agonist Nalfurafine for Binding to κ Receptor 1: Synthesis of Decahydroisoquinoline Derivatives and Their Pharmacologies2012

    • Author(s)
      Nagase H、Imaide S、Yamada T、Hirayama S、 Nemoto T、 Yamaotsu N、 Hirono S、 Fujii H
    • Journal Title

      CHEMICAL & PHARMACEUTICAL BULLETIN

      Volume: 60(8) Issue: 8 Pages: 945-948

    • DOI

      10.1248/cpb.c12-00336

    • NAID

      130001852522

    • ISSN
      0009-2363, 1347-5223
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590042, KAKENHI-PROJECT-23590133
  • [Journal Article] Synthesis of a Stable Iminium Salt and Propellane Derivatives2008

    • Author(s)
      Hiroshi Nagase
    • Journal Title

      The Journal of Organic Chemistry 73

      Pages: 8093-8096

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590105
  • [Journal Article] Synthesis of N-isobutylnoroxymorphone from naltrexone by a selective cyclopropane ring opening reaction2008

    • Author(s)
      Fujii, H. ; Osa, Y. ; Ishihara, M. ; Hanamura, S. ; Nemoto, T. ; Nakajima, M. ; Hasebe, K. ; Mochizuki, H. ; Nagase, H.
    • Journal Title

      Bioorg. Med. Chem. Lett. 18

      Pages: 4978-4981

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590105
  • [Journal Article] Novel cleavage reaction of the C16-N17 bond in naltrexone derivatives2008

    • Author(s)
      Fujii, H. ; Imaide, S. ; Watanabe, A. ; Nemoto, T. ; Nagase, H.
    • Journal Title

      Tetrahedron Lett 49

      Pages: 6293-6296

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590105
  • [Journal Article] Synthesis of a stable iminium salt and propellane derivatives2008

    • Author(s)
      Nagase, H. ; Yamamot, N. ; Nemoto, T. ; Yoza, K. ; Kamiya, K. ; Hirono, S. ; Momen, S. ; Izumimoto, N. ; Hasebe, K. ; Mochizuki, H. ; Fujii, H.
    • Journal Title

      J. Org. Chem. 73

      Pages: 8093-8096

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590105
  • [Patent] スルホンアミド誘導体またはその薬学的に許容される酸付加塩2017

    • Inventor(s)
      長瀬博、斉藤毅、柳沢正史、入鹿山容子
    • Industrial Property Rights Holder
      長瀬博、斉藤毅、柳沢正史、入鹿山容子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] Design and synthesis of orexin receptor selective ligands and their pharmacology2019

    • Author(s)
      H. Nagase,
    • Organizer
      Roman Pharmacists Association
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-15H05942
  • [Presentation] Development of photocaged adenosine2A receptor activator,2018

    • Author(s)
      Tsuyoshi Saitoh, Shuji Ioka, Mustafa Korkutata, Yohei Chitose, Manabu Abe, Michael Lazarus, and Hiroshi Nagase
    • Organizer
      The 13th International Symposium on Organic Reactions
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-15H05942
  • [Presentation] オレキシン受容体選択的リガンドの設計・合成2018

    • Author(s)
      長瀬博
    • Organizer
      第40回白金シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] オレキシン高発現マウスにおける心筋梗塞の予後改善2017

    • Author(s)
      石川 ゆい、村越 伸行、入鹿山 容子、小川 靖裕、内田 俊太郎、富永 拡、田尻 和子、長瀬 博、柳沢 正史
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎新聞文化ホール(長崎県長崎市)
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] Design and synthesis of orexin 1 receptor selective antagonists2017

    • Author(s)
      Sayaka Ohrui, Naoshi Yamamoto, Masahiro Yata, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Shigeto Hirayama, Masashi Yanagisawa, Hiroshi Nagase
    • Organizer
      Tsukuba Global Science Week (TGSW) 2017
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] キャップトリマー骨格を有するオレキシン受容体拮抗薬の設計・合成12017

    • Author(s)
      堀内惇平、大下隆一郎、南雲康行、山本直司、沓村憲樹、斉藤毅、入鹿山容子、石川有紀子、小川靖裕、柳沢正史、長瀬博
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] オレキシン1受容体拮抗薬YNT-707の必須構造部位検討2017

    • Author(s)
      大類彩、山本直司、岡田卓大、谷田誠浩、斉藤毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、渡邊友里恵、早川大地、合田浩明、柳沢正史、長瀬博
    • Organizer
      第61回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] 新規低分子量オレキシン受容体作動薬YNT-185の全身炎症後の活動回復作用の検討2017

    • Author(s)
      内田 俊太郎、入鹿山 容子、小川 靖裕、富永 拡、石川 ゆい、木山 麻衣子、斉藤 毅、長瀬 博、柳沢 正史
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎新聞文化ホール(長崎県長崎市)
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] Design and synthesis of orexin receptor selective ligands2017

    • Author(s)
      Nagase H
    • Organizer
      26th French-Japanese Symposium on Medicinal and Fine Chemistry
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-15H05942
  • [Presentation] モルヒナン骨格を有するオレキシン1受容体(OX1R)の特異的拮抗薬の設計・合成とOX1R結合の活性立体配座2017

    • Author(s)
      山本直司、大類彩、岡田卓大、谷田誠浩、斉藤毅、沓村憲樹、南雲康行、入鹿山容子、小川靖裕、石川有紀子、平山重人、渡辺友里恵、早川大地、合田浩明、柳沢正史、長瀬博
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] Design and synthesis of orexin receptor selective ligands2017

    • Author(s)
      Nagase H
    • Organizer
      26th French-Japanese Symposium on Medicinal and Fine Chemistry
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-15H05935
  • [Presentation] Design and synthesis of orexin receptor selective ligands2017

    • Author(s)
      Hiroshi Nagase
    • Organizer
      26th French-Japanese Symposium on Medicinal and Fine Chemistry
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] 低分子量オレキシン受容体2型作動薬YNT-185の組織学的、及び電気生理学的解析2017

    • Author(s)
      小川 靖裕、入鹿山 容子、富永 拡、細川 直人、斉藤 毅、長瀬 博、柳沢 正史
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎新聞文化ホール(長崎県長崎市)
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] キャップトリマー骨格を有するオレキシン受容体拮抗薬の設計・合成22017

    • Author(s)
      大下隆一郎、堀内惇平、南雲康行、山本直司、沓村憲樹、斉藤毅、入鹿山容子、石川有紀子、小川靖裕、柳沢正史、長瀬博
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] オレキシンリガンドの探索研究2017

    • Author(s)
      長瀬博
    • Organizer
      北海道大学大学院生命科学院 特別講義
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] トリマーリガンドの合成とその薬理作用2017

    • Author(s)
      長瀬博
    • Organizer
      全薬工業株式会社 特別講演
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] オレキシン受容体作動薬:創薬への展望2016

    • Author(s)
      長瀬博
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-ORGANIZER-15H05935
  • [Presentation] YNT-707のOX1Rアンタゴニスト活性発現のための必須構造の検討2016

    • Author(s)
      関 知範、中嶋 龍、斉藤 毅、入鹿山容子、小川靖裕、石川有紀子、柳沢正史、長瀬 博
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-12-01
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] ナルフラフィンの構造を基にしたオレキシン1受容体選択的拮抗薬の設計・合成およびその薬理作用2016

    • Author(s)
      山本直司、谷田誠浩、大類 彩、岡田卓大、斉藤 毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、平山重人、柳沢正史、長瀬 博
    • Organizer
      第36回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2016-06-19
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] モルヒナン骨格を有するオレキシン1受容体選択的拮抗薬の設計・合成とその薬理作用”2016

    • Author(s)
      大類 彩、山本直司、谷田誠浩、岡田卓大、斉藤 毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、平山重人、柳沢正史、長瀬 博
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] 低分子オレキシン受容体アゴニストの創製2016

    • Author(s)
      斉藤 毅、永原崇志、沓村憲樹、入鹿山容子、小川靖裕、富永 拡、黒田大介、合田浩明、藤井秀明、柳沢正史、長瀬 博
    • Organizer
      第60回日本薬学会関東支部大会
    • Place of Presentation
      東京大学本郷キャンパス(東京都文京区)
    • Year and Date
      2016-09-17
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] オレキシン2受容体作動薬YNT-185の創製2016

    • Author(s)
      斉藤 毅、永原崇志、沓村憲樹、中嶋 龍、細川直人、入鹿山容子、小川靖裕、富永 拡、黒田大介、合田浩明、藤井秀明、柳沢正史、長瀬 博
    • Organizer
      第34回メディシナルケミストリーシンポジウム サテライトセッション
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-11-30
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] モルヒナン骨格を有する新規オレキシン1受容体選択的拮抗薬の設計・合成①2016

    • Author(s)
      大類 彩、山本直司、谷田誠浩、岡田卓大、斉藤 毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、柳沢正史、長瀬 博
    • Organizer
      第60回日本薬学会関東支部大会
    • Place of Presentation
      東京大学本郷キャンパス(東京都文京区)
    • Year and Date
      2016-09-17
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] モルヒナン骨格を有する新規オレキシン1受容体選択的拮抗薬の設計・合成②2016

    • Author(s)
      岡田卓大、山本直司、谷田誠浩、大類 彩、斉藤 毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、平山重人、柳沢正史、長瀬 博
    • Organizer
      第60回日本薬学会関東支部大会
    • Place of Presentation
      東京大学本郷キャンパス(東京都文京区)
    • Year and Date
      2016-09-17
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] Design and Synthesis of Orexin 2 Receptor Agonists2016

    • Author(s)
      Hiroshi Nagase
    • Organizer
      Tsukuba Global Science Week 2016
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-09-19
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] Synthesis of Novel, Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton2016

    • Author(s)
      Naoshi Yamamoto, Masahiro Yata, Sayaka Ohrui, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Daisuke Kuroda, Hiroaki Gouda, Masashi Yanagisawa, Hiroshi Nagase
    • Organizer
      The 25th French-Japanese Symposium on Medicinal and Fine Chemistry
    • Place of Presentation
      Keio Plaza Hotel Tama(東京都多摩市)
    • Year and Date
      2016-05-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] オレキシン2受容体作動薬の設計・合成2016

    • Author(s)
      長瀬 博、永原 崇志、斉藤 毅、沓村 憲樹、入鹿山 容子、小川 靖裕、黒田 大祐、合田 浩明、藤井 秀明、柳沢 正史
    • Organizer
      第36回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2016-08-19
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] YNT-707のOX1R拮抗作用発現のための必須構造の検討2016

    • Author(s)
      関 知範、中嶋 龍、斉藤 毅、入鹿山容子、小川靖裕、石川有紀子、柳沢正史、長瀬 博
    • Organizer
      第60回日本薬学会関東支部大会
    • Place of Presentation
      東京大学本郷キャンパス(東京都文京区)
    • Year and Date
      2016-09-17
    • Data Source
      KAKENHI-PROJECT-16H05098
  • [Presentation] Design and synthesis of novel delta opioid agonists and their pharmacologies2015

    • Author(s)
      Nagase H
    • Organizer
      Drug Discovery & Therapy World Congress
    • Place of Presentation
      Boston, MA, USA
    • Year and Date
      2015-07-23
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-15H05935
  • [Presentation] DESIGN AND SYNTHESIS OF NOVEL δ OPIOID AGONISTS AND THEIR PHARMACOLOGIES2015

    • Author(s)
      Hiroshi. Nagase
    • Organizer
      Drug Discovery & Therapy World Congress 2015
    • Place of Presentation
      カインズコンベンションセンター(アメリカ、マサチューセッツ、ボストン)
    • Year and Date
      2015-07-23
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-15H05942
  • [Presentation] Design and synthesis of novel ligands of opioid receptors2015

    • Author(s)
      Hiroshi. Nagase
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      ヒルトンハワイアンヴィレッジ(アメリカ、ハワイ、ホノルル)
    • Year and Date
      2015-12-17
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-15H05942
  • [Presentation] Design and synthesis of novel ligands of opioid receptors2015

    • Author(s)
      Nagase H
    • Organizer
      Pacifichem
    • Place of Presentation
      Honolulu, HI, USA
    • Year and Date
      2015-12-17
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-15H05935
  • [Presentation] CellKey^<TM>システムを用いた作動活性評価とそれに基づく選択的オピオイドκ受容体作動薬ナルフラフィンの必須構造の検討2014

    • Author(s)
      藤井秀明、今出慧海、横山明信、須藤結香、平山重人、岩井孝志、山田貴明、根本徹、上園保仁、長瀬博
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Year and Date
      2014-03-28
    • Data Source
      KAKENHI-PROJECT-23590133
  • [Presentation] CellKeyTMシステムを用いた作動活性評価とそれに基づく選択的オピオイドκ受容体作動薬ナルフラフィンの必須構造の検討2014

    • Author(s)
      藤井秀明、今出慧海、横山明信、須藤結香、平山重人、岩井孝志、山田貴明、根本 徹、上園保仁、長瀬 博
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-23590133
  • [Presentation] CellKey™ systemを用いた新規δオピオイド受容体特異的アゴニストの開発及びスクリーニング2013

    • Author(s)
      横山明信、須藤結香、宮野加奈子、鈴木雅美、白石成二、平山重人、林田康平、藤井秀明、酒井潤一、神田貴史、中田恵理子、長瀬博、樋上賀一、上園保仁
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23590133
  • [Presentation] オキサアザトリシクロデカン骨格を有する新規オピオイドδ受容体作動薬の設計と合成、およびその薬理作用22013

    • Author(s)
      藤井秀明、林田康平、渡邉義一、齊藤大祐、高橋俊弘、酒井潤一、田中恵理子、神田貴史、岩井孝志、平山重人、根本徹、山川富雄、長瀬博
    • Organizer
      第33回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2013-09-07
    • Data Source
      KAKENHI-PROJECT-23590133
  • [Presentation] CellKey™systemを用いた新規δオピオイド受容体特異的アゴニストの開発及びスクリーニング2013

    • Author(s)
      横山明信、須藤結香、宮野加奈子、鈴木雅美、白石成二、平山重人、林田康平、藤井秀明、酒井潤一、神田貴史、中田恵理子、長瀬博、樋上賀一、上園保仁
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-22
    • Data Source
      KAKENHI-PROJECT-23590133
  • [Presentation] オキサアザトリシクロデカン骨格を有する新規オピオイドδ受容体作動薬の設計と合成、およびその薬理作用22013

    • Author(s)
      藤井秀明、林田康平、渡邉義一、齊藤大祐、高橋俊弘、酒井潤一、田中恵理子、神田貴史、岩井孝志、平山重人、根本 徹、山川富雄、長瀬 博
    • Organizer
      第33回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23590133
  • [Presentation] オキサアザトリシクロデカン骨格を有する新規オピオイドδ受容体作動薬の設計と合成、およびその薬理作用2012

    • Author(s)
      藤井秀明、林田康平、平山重人、岩井孝志、根本徹、酒井潤一、神田貴史、中田理恵子、上園保仁、長瀬博
    • Organizer
      第32回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-09-16
    • Data Source
      KAKENHI-PROJECT-23590133
  • [Presentation] 17-置換モルヒナン誘導体の合成と薬理作用2008

    • Author(s)
      藤井秀明、花村新一、山本直司、石原茉莉菜、長由美子、木綿しのぶ、長谷部光、望月英典、長瀬博
    • Organizer
      第29回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      富山
    • Data Source
      KAKENHI-PROJECT-19590105
  • [Presentation] ナルトレキソン16-17位の新規切断反応を用いたオピオイド受容体リガンドの合成2007

    • Author(s)
      今出 慧海、渡辺 晃生、藤井 秀明、長瀬 博
    • Organizer
      第51回日本薬学会関東支部大会
    • Place of Presentation
      星薬科大学
    • Year and Date
      2007-10-06
    • Data Source
      KAKENHI-PROJECT-19590105
  • [Presentation] ナルトレキソン16-17位の新規切断反応を用いたオピオイド受容体リガンドの合成2007

    • Author(s)
      今出 慧海、渡辺 晃生、藤井 秀明、長瀬 博
    • Organizer
      第33回反応と合成の進歩シンポジウム
    • Place of Presentation
      長崎ブリックホール
    • Year and Date
      2007-11-06
    • Data Source
      KAKENHI-PROJECT-19590105
  • [Presentation] ナルトレキソン16-17位の新規切断反応を用いたオピオイド受容体リガンドの合成2007

    • Author(s)
      今出慧海、渡邊晃生、藤井秀明、長瀬博
    • Organizer
      第51回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Year and Date
      2007-10-06
    • Data Source
      KAKENHI-PROJECT-19590105
  • [Presentation] PtO_2を用いるN-シクロプロピルメチル基の還元的開環反応2007

    • Author(s)
      花村新一、石原茉莉菜、長由美子、藤井秀明、長瀬博
    • Organizer
      第37回複素環討論会
    • Place of Presentation
      長野
    • Data Source
      KAKENHI-PROJECT-19590105
  • [Presentation] Synthesis of a novel opioid compound by rearrangement of morphine skeleton2007

    • Author(s)
      Yamamoto, N. ; Nagase, H.
    • Organizer
      19^<th> French-Japanese Synposium on Medicinal and Fine Chemistry
    • Place of Presentation
      Toyama
    • Year and Date
      2007-05-14
    • Data Source
      KAKENHI-PROJECT-19590105
  • [Presentation] PtO_2を用いるN-シクロプロピルメチル基の還元的開裂反応2007

    • Author(s)
      花村 新一、石原 茉莉菜、長 由美子、藤井 秀明、長瀬 博
    • Organizer
      第37回複素環化学討論会
    • Place of Presentation
      長野市若里市民文化ホール
    • Year and Date
      2007-10-18
    • Data Source
      KAKENHI-PROJECT-19590105
  • 1.  FUJII Hideaki (30458757)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 23 results
  • 2.  SUZUKI Tsutomu (90130757)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  柳沢 正史 (20202369)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 25 results
  • 4.  斉藤 毅 (80609933)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 28 results
  • 5.  NEMOTO Touru (40458766)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 6.  UEZONO Yasuhito (20213340)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 7.  HIRAYAMA Shigeto (40565842)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 12 results
  • 8.  古川 聡 (20726260)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  根井 充 (10164659)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  松崎 一葉 (10229453)
    # of Collaborated Projects: 1 results
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  • 11.  日出間 純 (20250855)
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  • 12.  東端 晃 (30360720)
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  • 13.  東谷 篤志 (40212162)
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  • 14.  成瀬 恵治 (40252233)
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  • 15.  瀬原 淳子 (60209038)
    # of Collaborated Projects: 1 results
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  • 16.  高橋 昭久 (60275336)
    # of Collaborated Projects: 1 results
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  • 17.  井上 夏彦 (60277811)
    # of Collaborated Projects: 1 results
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  • 18.  森田 啓之 (80145044)
    # of Collaborated Projects: 1 results
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  • 19.  岩崎 賢一 (80287630)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  那須 正夫 (90218040)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  村井 正 (10748958)
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  • 22.  嶋津 徹 (20639158)
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  • 23.  村上 敬司 (40421870)
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  • 24.  北川 博之 (00204876)
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  • 25.  徳山 薫平 (00207565)
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  • 26.  小久保 利雄 (30750004)
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  • 27.  浅田 知栄 (50344099)
    # of Collaborated Projects: 1 results
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  • 28.  船戸 弘正 (90363118)
    # of Collaborated Projects: 1 results
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  • 29.  桜井 武 (60251055)
    # of Collaborated Projects: 1 results
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  • 30.  入鹿山 容子 (90312834)
    # of Collaborated Projects: 1 results
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  • 31.  南雲 康行 (00459661)
    # of Collaborated Projects: 1 results
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  • 32.  IKEDA Satoshi
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    # of Collaborated Products: 1 results
  • 33.  MIZOGUCHI Hirokazu
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  • 34.  ラザルス ミハエル
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  • 35.  合田 浩明
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  • 36.  広野 修一
    # of Collaborated Projects: 0 results
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  • 37.  池田 弘子
    # of Collaborated Projects: 0 results
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  • 38.  塩田 清二
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  • 39.  竹ノ谷 文子
    # of Collaborated Projects: 0 results
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  • 40.  亀井 淳三
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  • 41.  黒田 大祐
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  • 42.  山本 直司
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  • 43.  櫻田 忍
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  • 44.  熊谷 英敏
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  • 45.  沓村 憲樹
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    # of Collaborated Products: 1 results
  • 46.  鈴木 雅美
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  • 47.  成田 年
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  • 48.  山乙 教之
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    # of Collaborated Products: 1 results

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