Kobayashi Takuya 小林拓也

… Alternative Names

KOBAYASHI Takuya 小林拓也

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Researcher Number	20311730
Other IDs
Affiliation (Current)	2025: 関西医科大学, 医学部, 教授 2025: 京都大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 関西医科大学, 医学部, 教授 2018 – 2019: 関西医科大学, 医学部, 教授 2017: 京都大学, 医学研究科, 准教授 2016: 京都大学, 医学部, 准教授 2012 – 2014: 京都大学, 医学(系)研究科(研究院), 准教授 … More 2011: 京都大学, 医学研究所, 講師 2008 – 2011: Kyoto University, 医学研究科, 講師 1999 – 2003: 京都大学, 医学研究科, 助手 2000 – 2001: 京都大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Medium-sized Section 48:Biomedical structure and function and related fields / General medical chemistry / Structural biochemistry / General medical chemistry / Basic Section 48040:Medical biochemistry-related Except Principal Investigator General medical chemistry / Biological pharmacy / General pharmacology / Structural biochemistry
Keywords	Principal Investigator プロスタノイド / X線結晶構造解析 / ノックアウトマウス / 抗体 / 結晶構造解析 / ストレス / プロスタグランジン / 構造解析 / GPCR / モノクローナル抗体 … More / バンド3 / アニオントランスポーター / 赤血球 / 行動 / 情動 / プロスタサイクリン / 受容体 / 動脈硬化 / クライオ電子顕微鏡 / バイアスリガンド / G蛋白質共役受容体 / シグナル伝達 / ヘテロ二量体 / オピオイド受容体 / 副作用 / オピオイド / 創薬 / 抗体医薬 / オルガノイド / 機能性抗体 / 膜タンパク質 / 転移 / 大腸がん / オーファン受容体 / アデノシンA2a受容体 / 立体構造認識抗体 / 共結晶 / X線結晶解析 / アポ蛋白E / 血管内皮細胞 / トロンボキサン / リガンド結合 / 変異 / 欠損マウス / アポ蛋白 / トロンポキサン … More Except Principal Investigator 膜タンパク質 / GPCR / X線結晶構造解析 / 創薬 / 機能性抗体 / 睡眠 / ナルコレプシー / 薬剤開発 / 抗体 / シグナル伝達 / ヒト膜受容体 / 概日時計 / G蛋白質共役受容体 / 視交叉上核 / オーファン受容体 / 体内時計 / G蛋白質共役型受容体 / ischemia-reperfusipn / platelets / allergic asthma / fertilization / prostanoid receptor / knockout mice / prostaglandin / prostanoids / 大腸癌 / 気管支喘息 / 肺高血圧症 / 中枢神経機能 / トロンボキサン / 虚血・再潅流 / 血小板 / アレルギー性喘息 / 受精 / プロスタノイド受容体 / ノックアウトマウス / プロスタグランジン / プロスタノイド / 陰イオン透過 / AE1 / 電子線構造解析 / X線構造解析 / 結晶化 / 膜貫通領域 / バンド3タンパク質 / 生体分子医学 / Mhp1 / X線結晶構造解 / 交互アクセス機構 / 交互アクセスモデル / トランスポーター / ヒダントイン / 輸送体 / X線結晶解析 Less

Development of selective signal regulation based on the complex structure of GPCR/signal transduction moleculePrincipal Investigator
- Principal Investigator
  
  小林拓也
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kansai Medical University
Clarification of the signal transduction mechanism of hetero-dimerized opioid receptors that cause side effects of opioidsPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Takuya
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  Kansai Medical University
Identification of target molecules aiming at development of new antibody medicine for colon cancer using structure biologyPrincipal Investigator
- Principal Investigator
  
  KOBSYASHI Takuya
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  Kansai Medical University
Differential analysis of the crystal structures of active / inactive orexin receptor contributing to rational development of sleep control drug
- Principal Investigator
  
  Suno Ryoji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
Identification and characterization of a potential drug target regulating the pace of the central circadian clock in the brain
- Principal Investigator
  
  Doi Masao
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoto University
Search for the endogenous ligad based on the orphan receptor structurePrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Takuya
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
Crystal structure of human Band3 (anion exchanger)Principal Investigator
- Principal Investigator
  
  KOBAYASHI TAKUY
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University
Development of antibody stabilizing active or inactive state of GPCRs.Principal Investigator
- Principal Investigator
  
  KOBAYASHI Takuya
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
Elucidation of the transport mechanism of a secondary active transporter, Mhp1.
- Principal Investigator
  
  SHIMAMURA Tatsuro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University
Structural Study on Human Red Cell Band 3 Protein, AE1.
- Principal Investigator
  
  HAMASAKI Naotaka
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Nagasaki International University
Crystal structure of human Band3 (anion exchanger)Principal Investigator
- Principal Investigator
  
  KOBAYASHI Takuya
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University
情動・ストレス反応におけるプロスタノイドの役割とその分子機構Principal Investigator
- Principal Investigator
  
  小林拓也
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
プロスタノイド受容体とアポ蛋白E欠損マウスの掛け合わせによる動脈硬化発症機構Principal Investigator
- Principal Investigator
  
  小林拓也
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
情動・ストレス反応におけるプロスタノイドの役割とその分子機構Principal Investigator
- Principal Investigator
  
  小林拓也
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
情動・ストレス反応におけるプロスタノイドの役割とその分子機構Principal Investigator
- Principal Investigator
  
  小林拓也
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
変異導入受容体を利用したプロスタノイド受容体のリガンド認識構造の解明Principal Investigator
- Principal Investigator
  
  小林拓也
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
プロスタノイド受容体とアポ蛋白E欠損マウスのかけ合わせによる動脈硬化発症機構Principal Investigator
- Principal Investigator
  
  小林拓也
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
Physiological and Pathophysiological roles of prostanoids revealed from studies using mice lacking their receptors
- Principal Investigator
  
  USHIKUBI Fumitaka
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Asahikawa Medical College

[Book] 「プロスタグランジン受容体の構造生物学」2023
- Author(s)
  寿野　良二、清水（小林）　拓也
- Total Pages
  50
- Publisher
  生物物理、63巻、1号p.16-20
- Data Source
  KAKENHI-PROJECT-21K19360
[Book] 「さまざまなプロスタグランジン受容体構造から見えたシグナル伝達の分子機構」2023
- Author(s)
  寿野　良二、清水（小林）　拓也
- Total Pages
  427
- Publisher
  クライオ電子顕微鏡ハンドブック
- Data Source
  KAKENHI-PROJECT-21K19360
[Book] Towards the Crystal Structure Determination of Muscarinic Acetylcholine Receptors.2016
- Author(s)
  Suno, R., Asada, H. and Kobayashi,T.
- Total Pages
  13
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-15K08268
[Book] GPCRの立体構造から解き明かす生命科学（実験医学　増刊 vol. 32　）2014
- Author(s)
  小林拓也、岩田想
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-24659132
[Book] Structural Proteomicis High-Through Methods “Screening of stable G-protein-coupled receptor variants in Saccharomyces cerevisiae.”2014
- Author(s)
  Shiroishi M. and Kobayashi T.
- Publisher
  Methods in Molecular Biology, Springer Protocols, Human Press
- Data Source
  KAKENHI-PROJECT-24659132
[Book] GPCRの立体構造から解き明かす生命科学2014
- Author(s)
  小林拓也, 岩田想
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23370049
[Book] 膜タンパク質の発現と精製　「昆虫細胞による生産」　膜タンパク質構造研究　最前線2013
- Author(s)
  浅田秀基、小林拓也
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-23370049
[Book] 「膜タンパク質」の重要性とその構造が拓く未来膜タンパク質構造研究　最前線2013
- Author(s)
  村田武士、小林拓也、野村紀通、岩田想
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-23370049
[Book] ムスカリン性アセチルコリン受容体の構造解析から創薬に向けて, 膜タンパク質構造研究最前線2013
- Author(s)
  小林拓也
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-23370049
[Book] 「膜タンパク質」の重要性とその構造が拓く未来, 膜タンパク質構造研究最前線2013
- Author(s)
  村田武士, 小林拓也, 野村紀通, 岩田想
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-23370049
[Book] 「膜タンパク質」の重要性とその構造が拓く未来　膜タンパク質構造研究　最前線2013
- Author(s)
  村田武士、小林拓也、野村紀通、岩田想
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-24659132
[Book] ムスカリン性アセチルコリン受容体の構造解析から創薬に向けて　膜タンパク質構造研究　最前線2013
- Author(s)
  小林拓也
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-24659132
[Book] 膜タンパク質の発現と精製　「昆虫細胞による生産」　膜タンパク質構造研究　最前線2013
- Author(s)
  浅田秀基、小林拓也
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-24659132
[Book] G蛋白質共役受容体のX線結晶構造解析の進歩, 血栓と循環2013
- Author(s)
  小林拓也
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-23370049
[Book] ムスカリン性アセチルコリン受容体の構造解析から創薬に向けて膜タンパク質構造研究　最前線2013
- Author(s)
  小林拓也
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-23370049
[Book] ムスカリン受容体の立体構造が明らかに, 医学のあゆみ2012
- Author(s)
  小林拓也
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-23370049
[Book] GPCRのX線結晶構造解析に成功するための技術的進展, 実験医学2012
- Author(s)
  小林拓也, 岩田想
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23370049
[Book] Gタンパク共役受容体(GPCR)の三次元結晶構造解析への試み2011
- Author(s)
  小林拓也
- Total Pages
  10
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-22659059
[Book] バイオインダストリーGタンパク質共役受容体(GPCR)の三次元結晶構造解析への試み2011
- Author(s)
  小林拓也
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-22659059
[Book] Advanced technologies to determine the 3D structure of taste receptors. The Sense of Taste.2011
- Author(s)
  K.Ito, T.Misaka, K.Abe, T.Kobayashi
- Publisher
  Nova Science Publishers, Inc.(印刷中)
- Data Source
  KAKENHI-PROJECT-20370035
[Book] バイオインダストリー Gタンパク質共役受容体(GPCR)の三次元結晶構造解析への試み2011
- Author(s)
  小林拓也
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-20370035
[Book] Gタンパク共役受容体(GPCR)の三次元結晶構造解析への試み, バイオインダストリー2011
- Author(s)
  小林拓也
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-23370049
[Book] Gタンパク質共役受容体(GPCR)の三次元結晶構造解析への試み、23-292011
- Author(s)
  小林拓也
- Publisher
  バイオインダストリー(シーエムシー出版)
- Data Source
  KAKENHI-PROJECT-20370035
[Journal Article] Interaction modes of human orexin 2 receptor with selective and nonselective antagonists studied by NMR spectroscopy2024
- Author(s)
  Imamura Kayo、Akagi Ken-Ichi、Miyanoiri Yohei、Tsujimoto Hirokazu、Hirokawa Takatsugu、Ashida Hideo、Murakami Kaori、Inoue Asuka、Suno Ryoji、Ikegami Takahisa、Sekiyama Naotaka、Iwata So、Kobayashi Takuya、Tochio Hidehito
- Journal Title
  
  Structure
  
  Volume: 32 Issue: 3 Pages: 352-361
- DOI
  10.1016/j.str.2023.12.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K05653, KAKENHI-PROJECT-23K05667, KAKENHI-PROJECT-20K06509, KAKENHI-PROJECT-21K19360, KAKENHI-PLANNED-19H05777, KAKENHI-PLANNED-21H05112, KAKENHI-PLANNED-21H05113, KAKENHI-PLANNED-22H05090, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-19H03428
[Journal Article] A Liquid Chromatography-Mass Spectrometry Method to Study the Interaction between Membrane Proteins and Low-Molecular-Weight Compound Mixtures2022
- Author(s)
  Hideo Ogiso, Ryoji Suno, Takuya Kobayashi, Masashi Kawami, Mikihisa Takano, Masaru Ogasawara
- Journal Title
  
  Molecules
  
  Volume: 27(15) Issue: 15 Pages: 4889-4889
- DOI
  10.3390/molecules27154889
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19360, KAKENHI-PLANNED-21H05112, KAKENHI-PROJECT-19H03428
[Journal Article] Structural insights into the G protein selectivity revealed by the human EP3-Gi signaling complex2022
- Author(s)
  Ryoji Suno, Yukihiko Sugita, Kazushi Morimoto, Hiroko Takazaki, Hirokazu Tsujimoto, Mika Hirose, Chiyo Suno-Ikeda, Norimichi Nomura, Tomoya Hino, Asuka Inoue, Kenji Iwasaki, Takayuki Kato, So Iwata, Takuya Kobayashi
- Journal Title
  
  Cell Rep.
  
  Volume: 40(11) Issue: 11 Pages: 111323-111323
- DOI
  10.1016/j.celrep.2022.111323
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19360, KAKENHI-PLANNED-21H05112, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-19H03428, KAKENHI-PUBLICLY-22H04753, KAKENHI-PLANNED-19H05777, KAKENHI-PROJECT-20H03434
[Journal Article] Vibrational spectroscopy analysis of ligand efficacy in human M2 muscarinic acetylcholine receptor (M2R)2021
- Author(s)
  Katayama Kota、Suzuki Kohei、Suno Ryoji、Kise Ryoji、Tsujimoto Hirokazu、Iwata So、Inoue Asuka、Kobayashi Takuya、Kandori Hideki
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 1-10
- DOI
  10.1038/s42003-021-02836-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H05440, KAKENHI-ORGANIZER-21H05111, KAKENHI-PLANNED-21H05112, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-19H03428, KAKENHI-PROJECT-21K19360, KAKENHI-PROJECT-21H04969, KAKENHI-PLANNED-19H05777, KAKENHI-PROJECT-23K21097
[Journal Article] Cryo-EM structure of the human MT1-Gi signaling complex.2021
- Author(s)
  Okamoto, H. H., Miyauchi, H., Inoue, A., Raimondi, F., Tsujimoto, H., Kusakizako, T., Shihoya, W., Yamashita, K., Suno, R., Nomura, N., Kobayashi, T., Iwata, S., Nishizawa, T. and Nureki, O.
- Journal Title
  
  Nat. Struct. Mol. Biol.
  
  Volume: 28 Issue: 8 Pages: 694-701
- DOI
  10.1038/s41594-021-00634-1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06294, KAKENHI-PLANNED-21H05112, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-19H03428, KAKENHI-PROJECT-21K19360, KAKENHI-PROJECT-20K15754, KAKENHI-PROJECT-22KJ0604, KAKENHI-PROJECT-21H05037, KAKENHI-PLANNED-19H05777
[Journal Article] Structural insights into the differences among lactisole derivatives in inhibitory mechanisms against the human sweet taste receptor.2019
- Author(s)
  Nakagita T, Ishida A, Matsuya T, Kobayashi T, Narukawa M, Hirokawa T, Hashimoto M, Misaka T.
- Journal Title
  
  PloS one
  
  Volume: 14
- NAID
  120007133042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19424
[Journal Article] Ligand Binding-Induced Structural Changes in the M2 Muscarinic Acetylcholine Receptor Revealed by Vibrational Spectroscopy.2019
- Author(s)
  K.Katayama, K. Suzuki, R. Suno, H. Tsujimoto, S. Iwata, T. Kobayashi, H. Kandori*
- Journal Title
  
  J Phys Chem Lett.
  
  Volume: 10(22) Issue: 22 Pages: 7270-7276
- DOI
  10.1021/acs.jpclett.9b02942
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H04959, KAKENHI-PROJECT-18H03986, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-19H03428, KAKENHI-PROJECT-18K19424, KAKENHI-PLANNED-19H05777
[Journal Article] Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface.2019
- Author(s)
  Toyoda Y, Morimoto K, Suno R, Horita S, Yamashita K, Hirata K, Sekiguchi Y, Yasuda S, Shiroishi M, Shimizu T, Urushibata Y, Kajiwara Y, Inazumi T, Hotta Y, Asada H, Nakane T, Shiimura Y, Nakagita T, Tsuge K, Kobayashi T et al,
- Journal Title
  
  Nature chemical biology
  
  Volume: 15 Pages: 18-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19424
[Journal Article] Crystal structure of the endogenous agonist-bound prostanoid receptor EP3.2019
- Author(s)
  Morimoto K, Suno R, Hotta Y, Yamashita K, Hirata K, Yamamoto M, Narumiya S, Iwata S, Kobayashi T
- Journal Title
  
  Nature chemical biology
  
  Volume: 15 Pages: 8-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19424
[Journal Article] Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog.2018
- Author(s)
  Asada H, Horita S, Hirata K, Shiroishi M, Shiimura Y, Iwanari H, Hamakubo T, Shimamura T, Nomura N, Kusano-Arai O, Uemura T, Suno C, Kobayashi T, Iwata S.
- Journal Title
  
  Nature structural & molecular biology
  
  Volume: 25 Pages: 570-576
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19424
[Journal Article] Structural insights into the subtype-selective antagonist binding to the M2 muscarinic receptor.2018
- Author(s)
  Suno R, Lee S, Maeda S, Yasuda S, Yamashita K, Hirata K, Horita S, Tawaramoto MS, Tsujimoto H, Murata T, Kinoshita M, Yamamoto M, Kobilka BK, Vaidehi N, Iwata S, Kobayashi T
- Journal Title
  
  Nature chemical biology
  
  Volume: 14 Pages: 1150-1158
- NAID
  130007811924
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19424
[Journal Article] Crystallization of Human Erythrocyte Band 3, the anion exchanger, at the International Space Station "KIBO".2018
- Author(s)
  Hatae H, Inaka K, Okamura R, Furubayashi N, Kamo M, Kobayashi T, Abe Y, Iwata S, Hamasaki N
- Journal Title
  
  Analytical biochemistry
  
  Volume: 559 Pages: 91-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19424
[Journal Article] Expanding the synthesizable multisubstituted benzo[b]thiophenes via 6,7-thienobenzynes generated from o-silylaryl triflate-type precursors.2018
- Author(s)
  Yoshida S, Kuribara T, Morita T, Matsuzawa T, Morimoto K, Kobayashi T, Hosoya T
- Journal Title
  
  RSC advances
  
  Volume: 8 Pages: 21754-21758
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19424
[Journal Article] Carbachol Induces phase-dependent phase shifts of Per1 transcription rhythms in cultured suprachiasmatic nucleus slices.2017
- Author(s)
  Dojo K, Yamaguchi Y, Fustin JM, Doi M, Kobayashi M, and Okamura H
- Journal Title
  
  J. Biol. Rhythms
  
  Volume: －
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293013
[Journal Article] Gpr176 is a Gz-linked orphan G-protein coupled receptor that sets the pace of circadian behavior.2016
- Author(s)
  Doi M, Murai I, Kunisue S, Setsu G, Uchio N, Tanaka R, Kobayashi S, Shimatani H, Hayashi H, Chao HW, Nakagawa Y, Takahashi Y, Hotta Y, Yasunaga JI, Matsuoka M, Hastings MH, Kiyonari H, and Okamura H.
- Journal Title
  
  Nat Commun
  
  Volume: 7 Issue: 1 Pages: 10583-10583
- DOI
  10.1038/ncomms10583
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460554, KAKENHI-INTERNATIONAL-15K21744, KAKENHI-PLANNED-15H05933, KAKENHI-PROJECT-15H01843, KAKENHI-PROJECT-15K15416, KAKENHI-PROJECT-26293013
[Journal Article] Towards the crystal structure determination of muscarinic acetylcholine receptors2016
- Author(s)
  Ryoji Suno, Hidetsugu Asada, Takuya Kobayashi
- Journal Title
  
  Neuromethods
  
  Volume: 107 Pages: 1-13
- DOI
  10.1007/978-1-4939-2858-3_1
- ISBN
  9781493928576, 9781493928583
- Data Source
  KAKENHI-PROJECT-15K08268
[Journal Article] Real-time recording of circadian Per1 and Per2 expression in the suprachiasmatic nucleus of freely moving rats.2016
- Author(s)
  Yamaguchi Y, Okada K, Mizuno T, Ota T, Yamada H, Doi M, Kobayashi M, Tei H, Shigeyoshi Y, and Okamura H
- Journal Title
  
  J. Biol. Rhythms.
  
  Volume: 31 Issue: 1 Pages: 108-111
- DOI
  10.1177/0748730415621412
- Peer Reviewed
- Data Source
  KAKENHI-INTERNATIONAL-15K21744, KAKENHI-PLANNED-15H05933, KAKENHI-PUBLICLY-26111710, KAKENHI-PROJECT-15H01843, KAKENHI-PROJECT-15H05642, KAKENHI-PROJECT-25350571, KAKENHI-PROJECT-15K12776, KAKENHI-PROJECT-15K15416, KAKENHI-PROJECT-26293013
[Journal Article] GPCRの立体構造から解き明かす生命科学2014
- Author(s)
  小林拓也、岩田想
- Journal Title
  
  実験医学増刊　羊土社
  
  Volume: Vol. 32, No. 10 Pages: 84-91
- Data Source
  KAKENHI-PROJECT-23370049
[Journal Article] G蛋白質共役受容体のX線結晶構造解析の進歩2013
- Author(s)
  小林拓也
- Journal Title
  
  血栓と循環　メディカルレビュー社
  
  Volume: Vol. 21, No. 3 Pages: 33-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370049
[Journal Article] Synthesis of photoreactive 2-phenethylamine derivatives Synthesis of adenosine derivative enabling functional analysis of adenosine receptors by photoaffinity labeling2013
- Author(s)
  Murai, Y., Masuda, K., Ogasawara, Y., Wang, L., Hashidoko, Y., Hatanaka, Y., Iwata, S., Kobayashi, T., and Hashimoto, M
- Journal Title
  
  Eur. J. Org. Chem
  
  Volume: 2013 Pages: 2428-2433
- NAID
  120005981508
- Data Source
  KAKENHI-PROJECT-23370049
[Journal Article] Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist2012
- Author(s)
  Haga, K., Kruse, A.C., Asada, H., Yurugi-Kobayashi, T., Shiroishi, M., Zhang, C., Weis, W.I., Okada, T., Kobilka, B.K., Haga, T. and Kobayashi, T
- Journal Title
  
  Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
  
  Volume: 482 Pages: 547-551
- NAID
  120003752107
- Data Source
  KAKENHI-PROJECT-23370049
[Journal Article] Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist2012
- Author(s)
  Haga K., et al
- Journal Title
  
  Nature
  
  Volume: 482 Issue: 7386 Pages: 547-551
- DOI
  10.1038/nature10753
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J40150, KAKENHI-PROJECT-22590270, KAKENHI-PROJECT-22659059, KAKENHI-PROJECT-23370049
[Journal Article] Platform for the rapid construction and evaluation of GPCRs for crystallography in Saccharomyces cerevisiae2012
- Author(s)
  Shiroishi, M., Tsujimoto, H., Makyio, H., Asada, H., Yurugi-Kobayashi, T., Shimamura, T., Nomura, N., Haga, T., Iwata, S. and *Kobayashi, T
- Journal Title
  
  Microb. Cell Fact
  
  Volume: 11 Pages: 78-78
- Data Source
  KAKENHI-PROJECT-23370049
[Journal Article] G protein-coupled receptor inactivation by an allosteric inverse-agonist antibody2012
- Author(s)
  Hino T., et al
- Journal Title
  
  Nature
  
  Volume: 482 Issue: 7384 Pages: 237-40
- DOI
  10.1038/nature10750
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J40150, KAKENHI-PROJECT-20221010, KAKENHI-PROJECT-22570114, KAKENHI-PROJECT-22659059, KAKENHI-PROJECT-23370049, KAKENHI-PROJECT-23657074
[Journal Article] Production of the stable human histamine H1 receptor in Pichia pastoris for structural determination2012
- Author(s)
  Shiroishi, M., Kobayashi, T., Ogasawara, S., Tsujimoto, H., Ikeda-Suno, C., Iwata, S. and Shimamura, T
- Journal Title
  
  Methods
  
  Volume: 55 Pages: 281-286
- Data Source
  KAKENHI-PROJECT-23370049
[Journal Article] protein-coupled receptor inactivation by an allosteric inverse-agonist antibody2012
- Author(s)
  Hino, T., Arakawa, T., Iwanari, H., Yurugi-Kobayashi, T., Ikeda-Suno, C., Nakada-Nakura, Y., Kusano-Arai, O., Weyand, S., Shimamura, T., Nomura, N., Cameron, A.D., Kobayashi, T., Hamakubo, T., Iwata, S. and Murata, T. G
- Journal Title
  
  Nature
  
  Volume: 482 Pages: 237-240
- Data Source
  KAKENHI-PROJECT-23370049
[Journal Article] Evaluation of the Pichia pastoris expression system for the production of GPCRs for structural analysis2011
- Author(s)
  Asada, H., Uemura, T., Yurugi-Kobayashi, T., Shiroishi, M., Shimamura, T., Tsujimoto, H., Ito, K., Sugawara, T., Nakane, T., Nomura, N., Murata, T., Haga, T., Iwata, S. and Kobayashi, T
- Journal Title
  
  Microb. Cell Fact
  
  Volume: 10 Pages: 24-24
- Data Source
  KAKENHI-PROJECT-23370049
[Journal Article] Evaluation of the Pichia pastoris expression system for the production of GPCRs for structural analysis.2011
- Author(s)
  H.Asada, T.Uemura, T.Yurugi-Kobayashi, M.Shiroishi, T.Shimamura, H.Tsujimoto, K.Ito, T.Sugawara, T.Nakane, N.Nomura, T.Murata, T.Haga, S.Iwata, T.Kobayashi.
- Journal Title
  
  Microbial Cell Factories (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370035
[Journal Article] Structure of the human histamine H1 receptor complex with doxepin2011
- Author(s)
  Shimamura, T., Shiroishi, M., Weyand, S., Tsujimoto, H., Winter, G., Katritch, V., Abagyan, R., Cherezov, V., Liu, W., Han, G.W., Kobayashi, T., Stevens, R.C. and Iwata, S
- Journal Title
  
  Nature
  
  Volume: 475 Pages: 65-70
- NAID
  120004225543
- Data Source
  KAKENHI-PROJECT-23370049
[Journal Article] Cysteine-to-serine shuffling using ayeast expression system improves proteinsecretion : case of a nonglycosylatedmutant of miracullin, a taste-modifyingprotein2011
- Author(s)
  Ito, K., Sugawara, T., Koizumi, A., Nakajima, K., Shimizu-Ibuka, A., Shiroishi, M., Asada, H., Yurugi-Kobayashi, T., Shimamura, T., Asada, T., Misaka, T., Iwata, S., Kobayashi, T. and Abe, K.
- Journal Title
  
  Biotech. Lett
  
  Volume: 33 Pages: 103-107
- URL
  http://www.springerlink.com/content/j624126g77180652/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659059
[Journal Article] Production of the stable human histamine H(1) receptor in Pichia pastoris for structural determination2011
- Author(s)
  Shiroishi M, Kobayashi T, Shimamura T., et al
- Journal Title
  
  Methods
  
  Volume: 55 Issue: 4 Pages: 281-286
- DOI
  10.1016/j.ymeth.2011.08.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370043, KAKENHI-PROJECT-23657074
[Journal Article] Cloning, expressionand purification of the anion exchanger 1homologue from basidiomycetePhanerochaete chrysosporium2011
- Author(s)
  Tokuda, N., Igarashi, K., Shimamura, T., Yurugi-Kobayashi, T., Shiroishi, M., Ito, K., Sugawara, T., Asada, H., Murata, T., Nomura, N., Iwata, S. and Kobayashi, T.
- Journal Title
  
  Protein Expr. Purif
  
  Volume: 79 Pages: 81-87
- URL
  http://www.sciencedirect.com/science/article/pii/S1046592811000866
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659059
[Journal Article] Production of the stable human histamine H(1) receptor in Pichia pastoris for structural determination2011
- Author(s)
  Shiroishi M, Kobayashi T, Ogasawara S, Tsujimoto H, Ikeda-Suno C, Iwata S, Shimamura T.
- Journal Title
  
  Methods.
  
  Volume: 55(4) Pages: 281-286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370043
[Journal Article] Structure ofthe human histamine H1 receptor complexwith doxepin.2011
- Author(s)
  Shimamura, T., Shiroishi, M, Weyand, S., Tsujimoto, H., Winter, G., Katritch, V., Abagyan, R., Cherezov, V., Liu, W., Han, G. W., Kobayashi, T., Stevens, R. C. and Iwata, S
- Journal Title
  
  Nature
  
  Volume: 475 Issue: 7354 Pages: 65-70
- DOI
  10.1038/nature10236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659059, KAKENHI-PROJECT-23657074
[Journal Article] Evaluation of the Pichia pastoris expression system for the production of GPCRs for structural analysis2011
- Author(s)
  Asada, H., Uemura, T., Yurugi-Kobayashi, T., Shiroishi, M., Shimamura, T., Tsujimoto, H., Ito, K., Sugawara, T., Nakane, T., Nomura, N., Murata, T., Haga, T., Iwata, S., Kobayashi, T
- Journal Title
  
  Microbial Cell Factories
  
  Volume: 10 Issue: 1 Pages: 24-24
- DOI
  10.1186/1475-2859-10-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J04341, KAKENHI-PROJECT-21370043, KAKENHI-PROJECT-22570114, KAKENHI-PROJECT-22590270
[Journal Article] Cloning, expression and purification of the anion exchanger 1 homologue from the basidiomycete Phanerochaete chrysosporium.2011
- Author(s)
  N.Tokuda, K.Igarashi, T.Shimamura, T.Yurugi-Kobayashi, M.Shiroishi, K.Ito, T.Sugawara, H.Asada, T.Murata, N.Nomura, S.Iwata, T.Kobayashi.
- Journal Title
  
  Protein Expr. Purif. (in press)
- NAID
  120003255719
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370035
[Journal Article] Cloning, expression and purification of the anion exchanger 1 homologue from the basidiomycete Phanerochaete chrysosporium2011
- Author(s)
  Tokuda N, Igarashi K, Shimamura T(co-1st author), Yurugi-Kobayashi T, Shiroishi M, Ito K, Sugawara T, Asada H, Murata T, Nomura N, Iwata S, Kobayashi T.
- Journal Title
  
  Protein. Expr. Purif.
  
  Volume: 79(1) Issue: 1 Pages: 81-7
- DOI
  10.1016/j.pep.2011.04.006
- NAID
  120003255719
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370043, KAKENHI-PROJECT-22570114, KAKENHI-PROJECT-22590270, KAKENHI-PROJECT-23657074
[Journal Article] Cysteine-to-serine shuffling using a yeast expression system improves protein secretion : case of a nonglycosylated mutant of miracullin, a taste-modifying protein2011
- Author(s)
  Ito, K., Sugawara, T., Koizumi, A., Nakajima, K., Shimizu-Ibuka, A., Shiroishi, M., Asada, H., Yurugi-Kobayashi, T., Shimamura, T., Asada, T., Misaka, T., Iwata, S., Kobayashi, T. and Abe, K
- Journal Title
  
  Biotech. Lett
  
  Volume: 33 Pages: 103-107
- Data Source
  KAKENHI-PROJECT-23370049
[Journal Article] Crystal structure of Glucansucrase from the dental caries pathogen Streptococcus mutans2011
- Author(s)
  Ito, K., Ito, S., Shimamura, T., Weyand, S., Kawarasaki, Y., Misaka, T., Abe, K., Kobayashi, T., Cameron, A.D., and Iwata S
- Journal Title
  
  J. Molecular Biology
  
  Volume: 408 Pages: 177-186
- Data Source
  KAKENHI-PROJECT-23370049
[Journal Article] Cloning, expression and purification of the anion exchanger 1 homologue from basidiomycete Phanerochaete chrysosporium2011
- Author(s)
  Tokuda, N., Igarashi, K., Shimamura, T., Yurugi-Kobayashi, T., Shiroishi, M., Ito, K., Sugawara, T., Asada, H., Murata, T., Nomura, N., Iwata, S. and Kobayashi, T
- Journal Title
  
  Protein Expr. Purif
  
  Volume: 79 Pages: 81-87
- NAID
  120003255719
- Data Source
  KAKENHI-PROJECT-23370049
[Journal Article] Crystal Structure of Glucansucrase from the Dental Caries Pathogen Streptococcus mutans2011
- Author(s)
  Ito K, Ito S, Shimamura T(co-1st author), Weyand S, Kawarasaki Y, Misaka T, Abe K, Kobayashi T, Cameron AD, Iwata S.
- Journal Title
  
  J. Mol. Biol.
  
  Volume: 408(2) Issue: 2 Pages: 177-86
- DOI
  10.1016/j.jmb.2011.02.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370043, KAKENHI-PROJECT-21760645, KAKENHI-PROJECT-23248058, KAKENHI-PROJECT-23780139
[Journal Article] Cysteine-to-serine shuffling using a yeast expression system improves protein secretion : case of a nonglycosylated mutant of miracullin, a taste-modifying protein.2011
- Author(s)
  K.Ito, T.Sugawara, A.Koizumi, K.Nakajima, A.Shimizu-Ibuka, M.Shiroishi, H.Asada, T.Yurugi-Kobayashi, T.Shimamura, T.Asada, T.Misaka, S.Iwata, T.Kobayashi, K.Abe.
- Journal Title
  
  Biotech. Lett. 33
  
  Pages: 103-107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370035
[Journal Article] Crystal structure of Glucansucrase form the dental caries pathogen Streptococcus mutans.2011
- Author(s)
  K.Ito, S.Ito, T.Shimamura, S.Weyand, Y.Kawarasaki, T.Misaka, K.Abe, T.Kobayashi, A.D.Cameron, S.Iwata.
- Journal Title
  
  J.Mol.Biol. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370035
[Journal Article] Evaluation of the Pichiapastoris expression system for theproduction of GPCRs for structuralanalysis2011
- Author(s)
  Asada, H., Uemura, T., Yurugi-Kobayashi, T., Shiroishi, M., Shimamura, T., Tsujimoto, H., Ito, K., Sugawara, T., Nakane, T., Nomura, N., Murata, T., Haga, T. Iwata, S. and Kobayashi, T.
- Journal Title
  
  Microb. Cell Fact
  
  Volume: 10 Pages: 24-24
- URL
  http://www.microbialcellfactories.com/content/10/1/24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659059
[Journal Article] Characterization of the β-D-glucopyranoside binding site of the human bitter taste receptor hTAS2R16.2010
- Author(s)
  T.Sakurai, T.Misaka, M.Ishiguro, K.Masuda, T.Sugawara, K.Ito, T.Kobayashi, S.Matsuo, Y.Ishimaru, T.Asakukra, K.Abe.
- Journal Title
  
  J.Biol. Chem. 285
  
  Pages: 28373-28378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370035
[Journal Article] Characterizationof the・-D-glucopyranoside binding siteof the human bitter taste receptorhTAS2R162010
- Author(s)
  Sakurai, T., Misaka, T., Ishiguro, M., Masuda, K., Sugawara, T., Ito, K., Kobayashi, T., Matsuo, S., Ishimaru, Y., Asakura, T. and Abe, K.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 285 Pages: 28373-28378
- URL
  http://www.jbc.org/content/285/36/28373.long
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659059
[Journal Article] Crystallization and preliminary X-ray analysis of a glucansucrase from the dental caries pathogen Streptococcus mutans2010
- Author(s)
  Ito K, Ito S, Shimamura T, Kawarasaki Y, Abe K, Misaka T, Kobayashi T, Iwata S.
- Journal Title
  
  Acta Crystallogr
  
  Volume: 66 Issue: 9 Pages: 1086-1088
- DOI
  10.1107/s1744309110029714
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370043
[Journal Article] Bulky high-mannose-type N-glycanblocks the taste-modifying activity ofmiraculin2010
- Author(s)
  Ito, K., Sugawara, T., Koizumi, A., Nakajima, K. I., Shimizu-Ibuka, A., Shiroishi, M., Asada, H., Yurugi-Kobayashi, T., Shimamura, T., Asakura, T., Masuda, K., Ishiguro, M., Misaka, T., Iwata, S., Kobayashi, T. and Abe, K.
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume: 1800 Pages: 986-992
- URL
  http://www.sciencedirect.com/science/article/pii/S0304416510001625
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659059
[Journal Article] Bulky high-mannose-type N-glycan blocks the taste-modifying activity of miraculin. Biochim.2010
- Author(s)
  K.Ito, T.Sugawara, A.Koizumi, K.I.Nakajima, A.Shimizu-Ibuka, M.Shiroishi, H.Asada, T.Yurugi-Kobayashi, T.Shimamura, T.Asakura, K.Masuda, M.Ishiguro, T.Misaka, S.Iwata, T.Kobayashi, K.Abe.
- Journal Title
  
  Biophys. Acta. 1800
  
  Pages: 986-992
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370035
[Journal Article] Crystallization and preliminary X-ray analysis of a Glucansucrase from the dental caries pathogen Streptococcus mutans.2010
- Author(s)
  K.Ito, S.Ito, T.Shimamura, Y.Kawarasaki, T.Kobayashi, S.Iwata.
- Journal Title
  
  Acta. Crystallogr. Sect.F 66
  
  Pages: 1086-1088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370035
[Journal Article] Crystallization and preliminary X-rayanalysis of a Glucansucrase from thedental caries pathogen Streptococcusmutans2010
- Author(s)
  Ito, K., Ito, S., Shimamura, T., Kawarasaki, Y., Kobayashi, T. and Iwata, S
- Journal Title
  
  Acta. Crystallogr. Sect. F
  
  Volume: 66(Pt9) Pages: 1086-1088
- URL
  http://scripts.iucr.org/cgi-bin/paper?S1744309110029714
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659059
[Journal Article] Fluorescence-based optimization of human bitter taste receptor expression in Saccharomyces cerevisiae.2009
- Author(s)
  T.Sugawara, K.Ito, M.Shiroishi, N.Tokuda, H.Asada, T.Yurugi-Kobayashi, T.Shimamura, T.Misaka, N.Nomura, T.Murata, K.Abe, S.Iwata, T.Kobayashi.
- Journal Title
  
  Biochem. Biophys. Res.Commun. 382
  
  Pages: 704-710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370035
[Journal Article] Comparison of functional non-glycosylated GPCRs expression in Pichia pastoris.2009
- Author(s)
  Takami Yurugi-Kobayashi, et al.
- Journal Title
  
  Biochemical and Biophysical Research Communiacations 380
  
  Pages: 271-276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370035
[Journal Article] Comparison of functional non-glycosylated GPCRs expression in Pichia pastoris.2009
- Author(s)
  T.Yurugi-Kobayashi, H.Asada, M.Shiroishi, T.Shimamura, S.Funamoto, N.Katsuta, K.Ito, T.Sugawara, N.Tokuda, H.Tsujimoto, T.Murata, N.Nomura, K.Haga, T.Haga, S.Iwata, T.Kobayashi.
- Journal Title
  
  Biochem. Biophys. Res.Commun. 380
  
  Pages: 271-276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370035
[Journal Article] Advanced method for high-throughput expression of mutated eukaryotic membrane proteins in Saccharomyces cerevisiae.2008
- Author(s)
  K.Ito, T.Sugawara, M.Shiroishi, N.Tokuda, A.Kurokawa, T.Misaka, H.Makyio, T.Yurugi-Kobayashi, T.Shimamura, N.Nomura, T.Murata, K.Abe, S.Iwata, T.Kobayashi.
- Journal Title
  
  Biochem. Biophys. Res.Commun. 371
  
  Pages: 841-845
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370035
[Journal Article] Interaction and stoichiometry of the peripheral stalk subunits NtpE and NtpF and the N-terminal hydrophilic domain of NtpI of Enterococcus hirae V-ATPase.2008
- Author(s)
  M.Yamamoto, S.Unzai, S.Saijo, K.Ito, K.Mizutani, C.Suno-Ikeda, Y.Yabuki-Miyata, T.Terada, M.Toyama, M.Shirouzu, T.Kobayashi, Y.Kakinuma, I.Yamato, S.Yokoyama, S.Iwata, T.Murata.
- Journal Title
  
  J.Biol.Chem. 283
  
  Pages: 19422-19431
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370035
[Patent] アゴニストの親和性を亢進する抗ヒトアデノシンA2a受容体モノクローナル抗体2012
- Inventor(s)
  小笠原諭, 日野智也, 島村達郎 , 荒川孝俊, 万木貴美, 寿野千代, 村田武士, 小林拓也, 岩田想
- Industrial Property Rights Holder
  独立行政法人科学技術振興機構
- Industrial Property Rights Type
  特許
- Filing Date
  2012-03-06
- Data Source
  KAKENHI-PROJECT-23370049
[Patent] 抗ヒトバンド3モノクローナル抗体2011
- Inventor(s)
  小林拓也, 小林貴美, 荒川孝俊, 日野智也, 村田武士, 野村紀通, 岩田想, 浜窪隆雄, 岩成宏子, 望月康弘, 濱崎直孝
- Industrial Property Rights Holder
  独立行政法人科学技術振興機構
- Industrial Property Rights Type
  特許
- Filing Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-23370049
[Patent] 抗ヒトバンド3モノクローナル抗体2011
- Inventor(s)
  小林拓也、小林貴美、荒川孝俊、日野智也、村田武士、野村紀通、岩田想、浜窪隆雄、岩成宏子、望月康弘、濱崎直孝
- Industrial Property Rights Holder
  独立行政法人科学技術振興機構
- Industrial Property Number
  2011-246364
- Filing Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-21590322
[Patent] 膜蛋白質の立体構造を認識するモノクローナル抗体のスクリーニング方法2010
- Inventor(s)
  小林拓也、岩田想, ら
- Industrial Property Rights Holder
  科学技術振興機構JST
- Filing Date
  2010
- Data Source
  KAKENHI-PROJECT-20370035
[Patent] 膜蛋白質の立体構造を認識するモノクローナル抗体のスクリーニング方法2010
- Inventor(s)
  岩田想・小林拓也・野村紀通
- Industrial Property Rights Holder
  科学技術振興機構
- Filing Date
  2010
- Overseas
- Data Source
  KAKENHI-PROJECT-22659059
[Presentation] プロスタグランジン受容体の立体構造を基盤とした創薬開発を目指して2023
- Author(s)
  小林拓也
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K19360
[Presentation] プロスタグランジン受容体の立体構造を基盤とした創薬開発を目指して2022
- Author(s)
  小林拓也
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K19360
[Presentation] クライオ電子顕微鏡によるプロスタグランジン受容体／Gタンパク質複合体の構造解析2021
- Author(s)
  小林拓也
- Organizer
  創薬等ライフサイエンス研究支援基盤事業令和3年度BINDS公開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21K19360
[Presentation] 2.抗炎症剤イブプロフェンの甘味受容体に対する阻害剤としての作用機構解析2019
- Author(s)
  中北　智哉、竹谷　千晶、成川　真隆、小林　拓也、三坂　巧
- Organizer
  日本農芸化学会2019年度大会
- Data Source
  KAKENHI-PROJECT-18K19424
[Presentation] 脊髄後角における疼痛関連タンパクBEGAIN陽性細胞の機能的特徴2019
- Author(s)
  片野泰代、今野幸太郎、西田和彦、渡辺雅彦、崎村建司、小林拓哉、伊藤誠二
- Organizer
  第42回日本神経科学大会/第62回日本神経化学大会/NEURO2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19424
[Presentation] 1.抗炎症剤イブプロフェンは甘味受容体の強力な阻害剤である2018
- Author(s)
  中北　智哉、成川真隆、小林　拓也、三坂巧
- Organizer
  日本味と匂学会第52回大会
- Data Source
  KAKENHI-PROJECT-18K19424
[Presentation] NMS (N-メチルスコポラミン)結合型ヒトムスカリン性アセチルコリン M2 受容体のX線結晶構造解析2016
- Author(s)
  寿野　良二、辻本　浩一、笹沼麻貴、山下　恵太郎、平田　邦生、Brian K Kobilka3、岩田　想、小林　拓也
- Organizer
  日本蛋白質科学会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-15K08268
[Presentation] High-resolution crystal structures of human orexin 2 receptor bound to a selective antagonist EMPA2016
- Author(s)
  Ryoji Suno, Kanako Terakado Kimura, Takanori Nakane, Kunio Hirata, Keitaro Yamashita, Junmei Wang, Takaaki Fujiwara, Yasuaki Yamanaka, Dohyun, Im, Shoichiro Horita, Hirokazu Tsujimoto, Maki S. Tawaramoto, Takatsugu Hirokawa, Masaki Yamamoto, Daniel M. Rosenbaum, So Iwata, Tatsuro Shimamura, and Takuya Kobayashi
- Organizer
  内藤カンファレンス
- Place of Presentation
  サッポロ　シャトレーゼ　ガトーキングダム
- Year and Date
  2016-10-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08268
[Presentation] Carbachol-induced biphasic phase-dependent phase-shift of core clock transcription rhythms in slice cultured suprachiasmatic nucleus2016
- Author(s)
  Kumiko Dojo, Yoshiaki Yamaguchi, Jean-Michel Fustin, Masao Doi, Masaki Kobayashi and Hitoshi Okamura
- Organizer
  第23回日本時間生物学会年会
- Place of Presentation
  名古屋
- Year and Date
  2016-11-12
- Data Source
  KAKENHI-PROJECT-26293013
[Presentation] シグナル伝達の選択的な制御を指向したGPCRの構造生命科学を目指して2015
- Author(s)
  小林拓也
- Organizer
  ERATO末松ガスバイオロジー最終研究成果報告会
- Place of Presentation
  東京
- Year and Date
  2015-01-29
- Invited
- Data Source
  KAKENHI-PROJECT-24659132
[Presentation] シグナル伝達の選択的な制御を指向したGPCRの構造生命科学2015
- Author(s)
  小林拓也
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-27
- Invited
- Data Source
  KAKENHI-PROJECT-24659132
[Presentation] Crystal structure of the human orexin 2 receptor (OX2R) bound to the selective antagonist EMPA2015
- Author(s)
  Ryoji Suno, Kunio Hirata, Keitaro Yamashita, Hirokazu Tsujimoto, Maki Sasanuma1, Masaki Yamamoto, Daniel M. Rosenbaum, So Iwata, Takuya Kobayashi
- Organizer
  GPCR workshop
- Place of Presentation
  ハワイ・コナ　シェラトンホテル
- Year and Date
  2015-12-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08268
[Presentation] G蛋白質共役受容体の構造生物学の進展とその創薬への応用2014
- Author(s)
  小林拓也
- Organizer
  第87回日本内分泌学会学術総会
- Place of Presentation
  福岡
- Year and Date
  2014-04-25
- Invited
- Data Source
  KAKENHI-PROJECT-24659132
[Presentation] GPCRの立体構造を認識する抗体から広がる新たな生命科学2014
- Author(s)
  小林拓也
- Organizer
  第87回日本内分泌学会学術総会
- Place of Presentation
  福岡
- Year and Date
  2014-04-25
- Invited
- Data Source
  KAKENHI-PROJECT-24659132
[Presentation] Crystallization of human GPCRs using antibody fragment.2014
- Author(s)
  Takuya Kobayashi
- Organizer
  6th Special Conference of the International Society for Neurochemistry
- Place of Presentation
  東京
- Year and Date
  2014-09-21
- Invited
- Data Source
  KAKENHI-PROJECT-24659132
[Presentation] Structural biology of membrane proteins and drug discovery -GPCR structure determination-2014
- Author(s)
  Takuya Kobayashi
- Organizer
  2nd International Symposium Kyoto University-National Taiwan University
- Place of Presentation
  京都
- Year and Date
  2014-09-01
- Invited
- Data Source
  KAKENHI-PROJECT-24659132
[Presentation] 未定2013
- Author(s)
  小林拓也
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-24659132
[Presentation] Crystallization of mammalian membrane proteins using antibody fragments2013
- Author(s)
  Kobayashi T.
- Organizer
  4th International Symposium on Diffraction Structural Biology
- Place of Presentation
  Nagoya
- Invited
- Data Source
  KAKENHI-PROJECT-24659132
[Presentation] GPCRのシグナル伝達分子機構の解明から創薬に向けて2013
- Author(s)
  小林拓也
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-24659132
[Presentation] Crystallization of human membrane proteins using antibody fragments2013
- Author(s)
  Kobayashi T.
- Organizer
  Protein Island Matsuyama (PIM) International Symposium 2013
- Place of Presentation
  Matsuyama
- Invited
- Data Source
  KAKENHI-PROJECT-24659132
[Presentation] Towards structure based GPCR pharmacology2012
- Author(s)
  小林拓也
- Organizer
  Gordon Research Conference
- Place of Presentation
  米国
- Data Source
  KAKENHI-PROJECT-23370049
[Presentation] Towards structure based GPCR pharmacology2012
- Author(s)
  小林拓也
- Organizer
  Gordon Research Conference
- Place of Presentation
  米国
- Data Source
  KAKENHI-PROJECT-22659059
[Presentation] Gタンパク共役受容体(GPCR)の三次元結晶構造解析への試み2011
- Author(s)
  小林拓也
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-03-24
- Data Source
  KAKENHI-PROJECT-20370035
[Presentation] Yeast expression : a GFP-based platform for rapid construction and evaluation of highly expressed and stable GPCR variants in S.cerevisiae.2010
- Author(s)
  Takuya Kobayashi
- Organizer
  GPCR Workshop
- Place of Presentation
  Hawaii(USA)(招待講演)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22659059
[Presentation] Yeast expression : a GFP-based platform for rapid construction and evaluation of highly expressed and stable GPCR variants in S.cerevisiae.2010
- Author(s)
  Takuya Kobayashi
- Organizer
  GPCR Workshop
- Place of Presentation
  Hawaii(USA)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-20370035
[Presentation] A GFP-based platform for rapid construction and evaluation of highly expressed and stable GPCR variants in Saccharomyces cerevisiae2010
- Author(s)
  小林拓也
- Organizer
  GPCR workshop
- Place of Presentation
  Hawaii
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-20370035
[Presentation] G蛋白質共役受容体 (GPCR) の構造解析に向けて「生産から結晶構造解析までの技術開発」シンポジウム2009
- Author(s)
  小林拓也
- Organizer
  日本生化学会
- Place of Presentation
  神戸
- Year and Date
  2009-10-21
- Data Source
  KAKENHI-PROJECT-20370035
[Presentation] G蛋白質共役受容体(GPCR)の構造解析に向けて「生産から結晶構造解析までの技術開発」2009
- Author(s)
  小林拓也
- Organizer
  第82回日本生化学会
- Place of Presentation
  神戸
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-20370035
[Presentation] Towards Structure Determination of Human Membrane Receptors and Production of Functional GPCRs in Pichi pastoris2008
- Author(s)
  小林拓也
- Organizer
  第5回GPCR研究会
- Place of Presentation
  東京
- Year and Date
  2008-05-09
- Data Source
  KAKENHI-PROJECT-20370035
[Presentation] Towards Structure Determination of Human Membrane Receptors -from Prostanoid receptor studies-、播磨放射光施設2008
- Author(s)
  小林拓也
- Organizer
  GPCRシンポジウム
- Year and Date
  2008-02-26
- Data Source
  KAKENHI-PROJECT-20370035
[Presentation] GPCRをターゲットにしたX線結晶構造解析の現状と今後の展望(シンポジウム)
- Author(s)
  小林拓也
- Organizer
  2012年日本神経化学会公開シンポジウム
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23370049
[Presentation] GPCRをターゲットにした『構造に指南された創薬』を目指すための三つの戦略
- Author(s)
  小林拓也
- Organizer
  構造活性フォーラム2012
- Place of Presentation
  京都市
- Invited
- Data Source
  KAKENHI-PROJECT-24659132
[Presentation] Towards Structure Based GPCRs Pharmacology; From Knockout Mice to Crystal Structures
- Author(s)
  Kobayashi, T.
- Organizer
  Gordon Research Conference
- Place of Presentation
  Venture, CA, USA
- Invited
- Data Source
  KAKENHI-PROJECT-23370049
[Presentation] 機能性抗体を利用したGPCRのX線結晶構造解析への試み
- Author(s)
  小林拓也
- Organizer
  千里ライフサイエンスセミナー
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-24659132
[Presentation] GPCRの構造解析と抗体の利用
- Author(s)
  小林拓也
- Organizer
  千里ライフサイエンスセミナー
- Place of Presentation
  大阪市
- Data Source
  KAKENHI-PROJECT-24659132
[Presentation] GPCRをターゲットにした『構造に指南された創薬』を目指すための三つの戦略
- Author(s)
  小林拓也
- Organizer
  構造活性フォーラム2012
- Place of Presentation
  京都市
- Invited
- Data Source
  KAKENHI-PROJECT-23370049
[Presentation] GPCRのX線結晶構造解析と創薬に必要なGPCRの構造情報について
- Author(s)
  小林拓也
- Organizer
  よこはまNMR構造生物学研究会　第47回ワークショップ
- Place of Presentation
  横浜市
- Invited
- Data Source
  KAKENHI-PROJECT-23370049
[Presentation] Crystallization of mammalian membrane proteins using antibody fragments.
- Author(s)
  Kobayashi T.
- Organizer
  4th International Symposium on Diffraction Structural Biology
- Place of Presentation
  Nagoya
- Invited
- Data Source
  KAKENHI-PROJECT-23370049
[Presentation] 機能性抗体を利用したGPCRのX線結晶構造解析への試み(シンポジウム)
- Author(s)
  小林拓也
- Organizer
  千里ライフサイエンスセミナー
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23370049
[Presentation] GPCRをターゲットにしたX線結晶構造解析の現状と今後の展望
- Author(s)
  小林拓也
- Organizer
  日本神経化学会公開シンポジウム
- Place of Presentation
  神戸市
- Invited
- Data Source
  KAKENHI-PROJECT-24659132
[Presentation] GPCRをターゲットにしたX線結晶構造解析の現状と今後の展望
- Author(s)
  小林拓也
- Organizer
  日本神経化学会公開シンポジウム
- Place of Presentation
  神戸市
- Invited
- Data Source
  KAKENHI-PROJECT-23370049
[Presentation] GPCRのX線結晶構造解析と創薬に必要なGPCRの構造情報について
- Author(s)
  小林拓也
- Organizer
  よこはまNMR構造生物学研究会　第47回ワークショップ
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-24659132
[Presentation] Crystallization of human membrane proteins using antibody fragments
- Author(s)
  Kobayashi, T
- Organizer
  Protein Island Matsuyama (PIM) International Symposium 2013
- Place of Presentation
  Matsuyama
- Invited
- Data Source
  KAKENHI-PROJECT-23370049
[Presentation] Molecular Basis of Antihistamine Specificity Against Human Histamine H1 Receptor(シンポジウム)
- Author(s)
  小林拓也
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23370049
[Presentation] Crystallization of mammalian membrane proteins using antibody fragments
- Author(s)
  Kobayashi, T
- Organizer
  4th International Symposium on Diffraction Structural Biology
- Place of Presentation
  Nagoya
- Invited
- Data Source
  KAKENHI-PROJECT-23370049
[Presentation] GPCRをターゲットにした「構造に指南された創薬」を目指すための三つの戦略
- Author(s)
  小林拓也
- Organizer
  構造活性フォーラム2012
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23370049
[Presentation] GPCRのシグナル伝達分子機構の解明から創薬に向けて
- Author(s)
  小林拓也
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜市
- Invited
- Data Source
  KAKENHI-PROJECT-23370049
[Presentation] 「GPCRの構造解析」から創薬は可能か?
- Author(s)
  小林拓也
- Organizer
  持田製薬株式会社
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-23370049
[Presentation] GPCRのX線結晶構造解析と創薬に必要なGPCRの構造情報について(シンポジウム)
- Author(s)
  小林拓也
- Organizer
  よこはまNMR構造生物学研究会第47回ワークショップ
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23370049
[Presentation] GPCRの構造解析と抗体の利用
- Author(s)
  小林拓也
- Organizer
  千里ライフサイエンスセミナー
- Place of Presentation
  大阪市
- Data Source
  KAKENHI-PROJECT-23370049
[Presentation] G蛋白共役受容体(GPCR)のX線結晶構造解析を成功させるための戦略(シンポジウム)
- Author(s)
  小林拓也
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23370049
[Presentation] G 蛋白共役受容体(GPCR)の結晶構造解析に向けた試み(シンポジウム)
- Author(s)
  小林拓也
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23370049
[Presentation] GPCRのシグナル伝達分子機構の解明から創薬に向けて(シンポジウム)
- Author(s)
  小林拓也
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23370049
[Presentation] Crystallization of human membrane proteins using antibody fragments.
- Author(s)
  Kobayashi T.
- Organizer
  Protein Island Matsuyama (PIM) International Symposium 2013
- Place of Presentation
  Matsuyama
- Invited
- Data Source
  KAKENHI-PROJECT-23370049
[Presentation] ムスカリン性アセチルコリン受容体M2サブタイプの三次元結晶構造解析に向けた試み(シンポジウム)
- Author(s)
  小林拓也
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23370049
[Presentation] 機能性抗体を利用したGPCRのX線結晶構造解析への試み
- Author(s)
  小林拓也
- Organizer
  千里ライフサイエンスセミナー
- Place of Presentation
  大阪市
- Invited
- Data Source
  KAKENHI-PROJECT-23370049
[]

1. IWATA So (60452330)

# of Collaborated Projects: 4 results

# of Collaborated Products: 18 results
2. HAMASAKI Naotaka (00091265)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. NOMURA Norimichi (10314246)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. Suno Ryoji (60447521)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
5. MURATA Takeshi (80415322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. SHIMAMURA Tatsuro (90391979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. SHIROISHI Mitsunori (00380527)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. KUMA Hiroyuki (40435136)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HIRAI Teruhisa (10450412)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YURUGI Takami (90467473)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
11. USHIKUBI Fumitaka (50243035)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. BITO Haruhiko (00291964)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. HARA Akiyoshi (90164988)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Doi Masao (20432578)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. OKAMURA Hitoshi (60158813)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. Yanagisawa Masashi (20202369)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. Saitoh Tsuyoshi (80609933)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 杉本幸彦 (80243038)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. Jean-Michel Fustin (50711818)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 井上明俊 (50709152)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 広川貴次 (20357867)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 細谷孝充 (60273124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. Kobilka Brian K

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. 安永純一朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. FUSTIN JM

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
26. 神取秀樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 片山耕大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 今村香代

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 山田哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 濡木理

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kobayashi Takuya 小林 拓也

KOBAYASHI Takuya 小林 拓也

Research Projects

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Co-Researchers

Development of selective signal regulation based on the complex structure of GPCR/signal transduction moleculePrincipal Investigator

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Clarification of the signal transduction mechanism of hetero-dimerized opioid receptors that cause side effects of opioidsPrincipal Investigator

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Identification of target molecules aiming at development of new antibody medicine for colon cancer using structure biologyPrincipal Investigator

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Differential analysis of the crystal structures of active / inactive orexin receptor contributing to rational development of sleep control drug

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Identification and characterization of a potential drug target regulating the pace of the central circadian clock in the brain

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Search for the endogenous ligad based on the orphan receptor structurePrincipal Investigator

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Crystal structure of human Band3 (anion exchanger)Principal Investigator

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Development of antibody stabilizing active or inactive state of GPCRs.Principal Investigator

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Elucidation of the transport mechanism of a secondary active transporter, Mhp1.

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Structural Study on Human Red Cell Band 3 Protein, AE1.

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Crystal structure of human Band3 (anion exchanger)Principal Investigator

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情動・ストレス反応におけるプロスタノイドの役割とその分子機構Principal Investigator

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プロスタノイド受容体とアポ蛋白E欠損マウスの掛け合わせによる動脈硬化発症機構Principal Investigator

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Project Period (FY)

Kobayashi Takuya 小林拓也

KOBAYASHI Takuya 小林拓也

[Book] GPCRの立体構造から解き明かす生命科学（実験医学　増刊 vol. 32　）2014

[Book] 膜タンパク質の発現と精製　「昆虫細胞による生産」　膜タンパク質構造研究　最前線2013

[Book] 「膜タンパク質」の重要性とその構造が拓く未来膜タンパク質構造研究　最前線2013