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KOJIMA Yuko  小島 裕子

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小島 裕子  コジマ ユウコ

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Researcher Number 60231312
Other IDs
Affiliation (Current) 2021: 順天堂大学, 医学(系)研究科(研究院), 助教
Affiliation (based on the past Project Information) *help 2019: 順天堂大学, 医学(系)研究科(研究院), 助教
2016: 順天堂大学, 医学研究科, 助教
2012 – 2016: 順天堂大学, 医学(系)研究科(研究院), 助教
2013: 順天堂大学, 医学研究科, 助教
2011: 順天堂大学, 医学研究科, 助教
2008: Juntendo University, 医学研究科, 助教
2007: Juntendo University, 大学院・医学研究科, 助教
Review Section/Research Field
Principal Investigator
General pharmacology / Biological pharmacy / Basic Section 50010:Tumor biology-related
Except Principal Investigator
膠原病・アレルギー・感染症内科学 / Pathological medical chemistry / Experimental pathology
Keywords
Principal Investigator
アポトーシス / TRAIL / 腫瘍細胞 / 抗腫瘍免疫 / DR5 / 局在 / がん抗体療法 / 胆管閉塞 / Importin β1 / PSC … More / TRAILレセプター / 分子局在 / がん治療 / インポーチン / Death receptor 5 / Death receptor / 薬物 / DR5 localization / TRAIL-resistant tumor / Importin β1 inhibition / Agonistic antibody / Cancer therapy / 局在制御 / 分子標的がん治療 / 細胞内輸送 … More
Except Principal Investigator
自己免疫疾患 / 関節リウマチ / 抗体療法 / 喘息 / アレルギー・喘息 / アレルギー・喘息 / TIM-4 / コラーゲン誘発性関節炎 / 抗炎症作用 / レポーターマウス / 大腸炎 / IL-11 / 大腸がん / IL-6サイトカインファミリー / 粘膜 / サイトカイン / 修復 / 大腸癌 / il-6サイトカインファミリー / 恒常性 / 腸炎 / 腸管 / 免疫学 / アレルギー疾患 / 炎症 / アレルギー・ぜんそく Less
  • Research Projects

    (6 results)
  • Research Products

    (23 results)
  • Co-Researchers

    (25 People)
  •  Regulation mechanism of apoptosis-inducing death receptor localization allowing for survival in tumor cellsPrincipal InvestigatorOngoing

    • Principal Investigator
      小島 裕子
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Juntendo University
  •  Elucidation of mucosal repair mechanism mediated by interleukin 11 in inflammatory bowel disease

    • Principal Investigator
      NISHINA Takashi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Toho University
  •  Immune regulation on autoimmune and allergic diseases by the TIM family molecules

    • Principal Investigator
      Okumura Ko
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Juntendo University
  •  A new cancer therapy by intracellular localization control of apoptosis inducing death receptor in tumor cellsPrincipal Investigator

    • Principal Investigator
      KOJIMA Yuko
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Juntendo University
  •  Development of the antibody medical treatment to autoimmune and asthmatic diseases based on new target molecule.

    • Principal Investigator
      OKUMURA Ko
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Juntendo University
  •  Contribution of intracellular TRAIL receptor to regulation of apoptosis induced by TRAILPrincipal Investigator

    • Principal Investigator
      KOJIMA Yuko
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Juntendo University

All 2020 2019 2017 2016 2015 2013 2011 2008

All Journal Article Presentation

  • [Journal Article] Inhibition of Importin β1 Augments the Anticancer Effect of Agonistic Anti-Death Receptor 5 Antibody in TRAIL-resistant Tumor Cells.2020

    • Author(s)
      Yuko Kojima, Takashi Nishina, Hiroyasu Nakano, Ko Okumura, Kazuyoshi Takeda
    • Journal Title

      Mol. Cancer Ther.

      Volume: 19-5 Pages: 1123-1133

    • DOI

      10.1158/1535-7163.mct-19-0597

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07648, KAKENHI-PROJECT-17H04069, KAKENHI-PROJECT-18H02695, KAKENHI-PROJECT-18K19483
  • [Journal Article] Depletion of myeloid cells exacerbates hepatitis and induces an aberrant increase in histone H3 in mouse serum2017

    • Author(s)
      Piao X, Yamazaki S, Komazawa-Sakon S, Miyake S, Nakabayashi O, Kurosawa T, Mikami T, Tanaka M, Van Rooijen N, Ohmuraya M, Oikawa A, Kojima Y, Kakuta S, Uchiyama Y, Tanaka M, Nakano H.
    • Journal Title

      Hepatology

      Volume: 65 Pages: 237-252

    • DOI

      10.1002/hep.28878

    • NAID

      120006528815

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26110003, KAKENHI-PLANNED-26110007, KAKENHI-PROJECT-26460397, KAKENHI-PROJECT-16K01378, KAKENHI-PROJECT-16K08747, KAKENHI-PROJECT-16K09398, KAKENHI-PROJECT-16K15681, KAKENHI-PROJECT-16H00591, KAKENHI-PROJECT-16K08789, KAKENHI-PLANNED-26110006, KAKENHI-PROJECT-17H04068
  • [Journal Article] IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting2017

    • Author(s)
      Takeda K, Nakayama M, Hayakawa Y, Kojima Y, Ikeda H, Imai N, Ogasawara K, Okumura K, Thomas DM, Smyth MJ
    • Journal Title

      Nature Communications

      Volume: 8 Pages: 14607-14607

    • DOI

      10.1038/ncomms14607

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06497, KAKENHI-PROJECT-16H02960, KAKENHI-PROJECT-16H05530, KAKENHI-PROJECT-26460397, KAKENHI-PROJECT-15K14410, KAKENHI-PROJECT-16K15112, KAKENHI-PROJECT-15H04918
  • [Journal Article] Critical contribution of nuclear factor erythroid 2-related factor 2 (NRF2) to electrophile-induced interleukin-11 production2017

    • Author(s)
      Nishina T, Deguchi Y, Miura R, Yamazaki S, Shinkai Y, Kojima Y, Okumura K, Kumagai Y, Nakano H.
    • Journal Title

      J. Biol. Chem.

      Volume: 292 Pages: 205-216

    • DOI

      10.1074/jbc.m116.744755

    • NAID

      130006581894

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PUBLICLY-15H01392, KAKENHI-PLANNED-26110003, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-26460397, KAKENHI-PROJECT-16K01378, KAKENHI-PROJECT-16K08747, KAKENHI-PROJECT-16K15681
  • [Journal Article] Development of Accelerated Coronary Atherosclerosis Model Using Low Density Lipoprotein Receptor Knock-Out Swine with Balloon Injury.2016

    • Author(s)
      Ogita M, Miyauchi K, Onishi A, Tsuboi S, Wada H, Konishi H, Naito R, Dohi T, Kasai T, Kojima Y, Schwartz RS, Daida H.
    • Journal Title

      PLoS One.

      Volume: 11

    • DOI

      10.1371/journal.pone.0163055

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460397
  • [Journal Article] TIM-4 has dual function in the induction and effector phases of murine arthritis.2013

    • Author(s)
      Abe Y, Kamachi F, Kawamoto T, Makino F, Ito J, Kojima Y, Moustapha Ael D, Usui Y, Yagita H, Takasaki Y, Okumura K, Akiba H.
    • Journal Title

      J Immunol

      Volume: 191 Pages: 4562-72

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390260
  • [Journal Article] TIM-4 has dual function in the induction and effector phases of murine arthritis.2013

    • Author(s)
      Abe Y, Kamachi F, Kawamoto T, Makino F, Ito J, Kojima Y, Moustapha Ael D, Usui Y, Yagita H, Takasaki Y, Okumura K, Akiba H
    • Journal Title

      J Immunol

      Volume: 191巻 Pages: 4562-4572

    • DOI

      10.4049/jimmunol.1203035

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-13J10815, KAKENHI-PROJECT-23390260, KAKENHI-PROJECT-25461503
  • [Journal Article] Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells2011

    • Author(s)
      Kawamoto T, Abe Y, Ito J, Makino F, Kojima Y, Usui Y, Ma J, Morimoto S, Yagita H, Okumura K, Takasaki Y, Akiba H
    • Journal Title

      Arthritis Res Ther

      Volume: 13

    • DOI

      10.1186/ar3288

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591098, KAKENHI-PROJECT-23390260
  • [Journal Article] Importin beta1 Protein-mediated Nuclear Localization of Death Receptor 5 (DR5) Limits DR5/Tumor Necrosis Factor (TNF)-related Apoptosis-inducing Ligand (TRAIL)-induced Cell Death of Human Tumor Cells2011

    • Author(s)
      Kojima Y, Nakayama M, Nishina T, Nakano H, Koyanagi M, Takeda K, Okumura K, Yagita H
    • Journal Title

      JOURNAL OF BIOLOGICAL CHEMISTRY

      Volume: 286 Pages: 43383-43393

    • DOI

      10.1074/jbc.m111.309377

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089, KAKENHI-PUBLICLY-23112519, KAKENHI-PUBLICLY-23117717, KAKENHI-PROJECT-23300355, KAKENHI-PROJECT-23390260, KAKENHI-PROJECT-23659404
  • [Journal Article] Crucial role for autophagy in degranulation of mast cells.2011

    • Author(s)
      Ushio, et al
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 127 Pages: 1267-1276

    • DOI

      10.1016/j.jaci.2010.12.1078

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23117717, KAKENHI-PROJECT-23390260, KAKENHI-PROJECT-23590576, KAKENHI-PROJECT-23659404
  • [Journal Article] Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease.2008

    • Author(s)
      Takeda K, Kojima Y, Ikejima K, Harada K, Yamashina S, Okumura K, Aoyama T, Frese s, Ikeda H, Hynes NM, Cretney E, Yagita H, Sueyoshi N, Sato N, Nakanuma Y, Smyth MJ, Okumura K
    • Journal Title

      Proc Natl Acad Sci U S A 105(31)

      Pages: 10895-10900

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590257
  • [Journal Article]2008

    • Author(s)
      Takeda K, Kojima Y, Ikejima K, Harada K, Yamashina S, Okumura K, Aoyama T, Fress S, Ikeda H, Hynes NM, Cretney E, Yagita H, Sueyoshi N, Sato N, Nakanuma Y, Smyth MJ, Okumura K
    • Journal Title

      Proc Natl Sci USA 105(31)

      Pages: 10895-10900

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590257
  • [Presentation] Importin β1 inhibition augments anticancer effect of anti-DR5 agonistic antibody in TRAIL resistant tumor cells2019

    • Author(s)
      Yuko Kojima, Takashi Nishina, Hiroyasu Nakano, Ko Okumura, Kazuyoshi Takeda
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K07648
  • [Presentation] 親電子リガンドによるIL-11産生機構とその生体における役割の解明2017

    • Author(s)
      仁科隆史、出口裕、三浦亮介、新開泰弘、小島裕子、奥村康、熊谷嘉人、中野裕康
    • Organizer
      第44回日本毒性学会学術年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2017-07-12
    • Data Source
      KAKENHI-PROJECT-26460397
  • [Presentation] Analysis of Interleukin-11-producing cells in a colitis-associated cancer model using IL-11 reporter mice2017

    • Author(s)
      Takashi Nishina, Yutaka Deguchi, Eri Nakamura, Yuko Kojima, Norihiro Tada, Hiroyasu Nakano
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology
    • Place of Presentation
      Keystone, Colorado, USA
    • Year and Date
      2017-02-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460397
  • [Presentation] 親電子リガンドによるIL-11産生機構とその生体における役割の解明2016

    • Author(s)
      仁科隆史、出口裕、三浦亮介、新開泰弘、小島裕子、熊谷嘉人、中野裕康
    • Organizer
      第89回日本生化学大会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2016-09-25
    • Data Source
      KAKENHI-PROJECT-26460397
  • [Presentation] がん細胞特異的細胞死誘導分子の局在に着目した分子標的がん治療の新たな展開2015

    • Author(s)
      小島裕子, 仁科隆史, 中野裕康, 八木田秀雄, 竹田和由
    • Organizer
      第38回 日本分子生物学会大会 第88回 日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド (兵庫県神戸市)
    • Year and Date
      2015-12-02
    • Data Source
      KAKENHI-PROJECT-26460397
  • [Presentation] インターロイキン(IL)-11を介した生体の恒常性維持機構の解析2015

    • Author(s)
      仁科隆史, 出口裕, 大塚正人, 中村衣里, 小島裕子, 多田昇弘, 中野裕康
    • Organizer
      第15回日本蛋白質科学会年会
    • Place of Presentation
      あわぎんホール (徳島県徳島市)
    • Year and Date
      2015-06-24
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460397
  • [Presentation] インターロイキン(IL)-11レポ-ターマウスを用いた炎症性大腸発がんモデルにおけるIL-11産生細胞の解析2015

    • Author(s)
      仁科隆史, 出口裕, 大塚正人, 中村衣里, 小島裕子, 三上哲夫, 多田昇弘, 中野裕康
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド (兵庫県神戸市)
    • Year and Date
      2015-12-02
    • Data Source
      KAKENHI-PROJECT-26460397
  • [Presentation] 大腸がんの発症と進行におけるInterleukin-11の産生細胞の免疫組織化学的解析2015

    • Author(s)
      出口裕, 仁科隆史, 大塚正人, 中村衣里, 小島裕子, 三上哲夫, 多田昇弘, 中野裕康
    • Organizer
      第38回 日本分子生物学会大会 第88回 日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド (兵庫県神戸市)
    • Year and Date
      2015-12-02
    • Data Source
      KAKENHI-PROJECT-26460397
  • [Presentation] Anti-TIM-4 mAb ameliorates allergic lung inflammation by inhibiting TIM-4-mediated mast cell stimulation2013

    • Author(s)
      F. Kamachi, M. Hara, N. Harada, Y. Katsura, Y. Kojima, K. Izawa, C. Nishiyama, K. Okumura, H. Akiba
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Data Source
      KAKENHI-PROJECT-23390260
  • [Presentation]2008

    • Author(s)
      Takeda K, Kojima Y, Yagita H, Smyth MJ, Okumura K
    • Organizer
      第38回日本免疫学会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2008-12-01
    • Data Source
      KAKENHI-PROJECT-19590257
  • [Presentation]2008

    • Author(s)
      Kojima Y, Takeda K, Yagita H, Smyth MJ, Okumura K
    • Organizer
      第38回日本免疫学会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2008-12-01
    • Data Source
      KAKENHI-PROJECT-19590257
  • 1.  OKUMURA Ko (50009700)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 9 results
  • 2.  AKIBA Hisaya (60338316)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 3.  YAGITA Hideo (30182306)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 4.  TAKEDA Kazuyoshi (80272821)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 5.  NAKANO Hiroyasu (70276476)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 6.  NISHINA Takashi (50598365)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 7.  出口 裕 (10287526)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 8.  HARADA Kenichi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 9.  KAMACHI Fumitaka
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  HARADA Norihiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  ABE Yoshiyuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  ISSHIKI Takuma
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  OHMURAYA Masaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  PIAO Xuehua
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  TANAKA Minoru
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  OIKAWA Akira
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  NAKAYAMA Masafumi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  IKEDA Hiroaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  SHINKAI Yasuhiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  山崎 創
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 21.  中林 修
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  田中 正人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  小笠原 康悦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 24.  西田 圭吾
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  熊谷 嘉人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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