Kojima Yuko 小島裕子

… Alternative Names

小島裕子コジマユウコ

KOJIMA Yuko 小島裕子

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Researcher Number	60231312
Other IDs
Affiliation (Current)	2025: 順天堂大学, 大学院医学研究科, 助教
Affiliation (based on the past Project Information) *help	2021 – 2023: 順天堂大学, 大学院医学研究科, 助教 2019 – 2020: 順天堂大学, 医学(系)研究科(研究院), 助教 2016: 順天堂大学, 医学研究科, 助教 2012 – 2016: 順天堂大学, 医学(系)研究科(研究院), 助教 2013: 順天堂大学, 医学研究科, 助教 … More 2011: 順天堂大学, 医学研究科, 助教 2008: Juntendo University, 医学研究科, 助教 2007: Juntendo University, 大学院・医学研究科, 助教 Less
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Biological pharmacy / General pharmacology Except Principal Investigator Experimental pathology / Pathological medical chemistry / 膠原病・アレルギー・感染症内科学
Keywords	Principal Investigator 腫瘍細胞 / TRAIL / アポトーシス / 局在 / DR5 / 分子標的がん治療 / 局在制御 / Agonistic antibody / Importin β1 inhibition / TRAIL-resistant tumor … More / DR5 localization / タンパク質発現調節 / ゴルジ装置 / SUMO化 / 細胞内輸送 / 細胞膜 / 核 / 細胞死 / SUMOylation / Cancer therapy / Intracellular transport / Nucleus / Localization / Cell deth / Tumor cells / 薬物 / Death receptor / Death receptor 5 / インポーチン / がん治療 / 分子局在 / TRAILレセプター / PSC / Importin β1 / 胆管閉塞 / がん抗体療法 / 抗腫瘍免疫 … More Except Principal Investigator 自己免疫疾患 / アレルギー・ぜんそく / 炎症 / アレルギー疾患 / 免疫学 / 腸管 / 腸炎 / 恒常性 / il-6サイトカインファミリー / 大腸癌 / 修復 / サイトカイン / 粘膜 / IL-6サイトカインファミリー / 大腸がん / IL-11 / 大腸炎 / レポーターマウス / 抗炎症作用 / コラーゲン誘発性関節炎 / TIM-4 / アレルギー・喘息 / アレルギー･喘息 / 喘息 / 抗体療法 / 関節リウマチ Less

Regulation mechanism of apoptosis-inducing death receptor localization allowing for survival in tumor cellsPrincipal Investigator
- Principal Investigator
  
  Kojima Yuko
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Juntendo University
Elucidation of mucosal repair mechanism mediated by interleukin 11 in inflammatory bowel disease
- Principal Investigator
  
  NISHINA Takashi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Toho University
Immune regulation on autoimmune and allergic diseases by the TIM family molecules
- Principal Investigator
  
  Okumura Ko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Juntendo University
A new cancer therapy by intracellular localization control of apoptosis inducing death receptor in tumor cellsPrincipal Investigator
- Principal Investigator
  
  KOJIMA Yuko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Juntendo University
Development of the antibody medical treatment to autoimmune and asthmatic diseases based on new target molecule.
- Principal Investigator
  
  OKUMURA Ko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Juntendo University
Contribution of intracellular TRAIL receptor to regulation of apoptosis induced by TRAILPrincipal Investigator
- Principal Investigator
  
  KOJIMA Yuko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Juntendo University

All 2020 2019 2017 2016 2015 2013 2011 2008

All Journal Article Presentation

[Journal Article] Inhibition of Importin β1 Augments the Anticancer Effect of Agonistic Anti-Death Receptor 5 Antibody in TRAIL-Resistant Tumor Cells2020
- Author(s)
  Yuko Kojima, Takashi Nishina, Hiroyasu Nakano, Ko Okumura, Kazuyoshi Takeda
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 19-5 Issue: 5 Pages: 1123-1133
- DOI
  10.1158/1535-7163.mct-19-0597
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07648, KAKENHI-PROJECT-17H04069, KAKENHI-PROJECT-18H02695, KAKENHI-PROJECT-18K19483, KAKENHI-PROJECT-20H03475, KAKENHI-PROJECT-19K07391
[Journal Article] Depletion of myeloid cells exacerbates hepatitis and induces an aberrant increase in histone H3 in mouse serum2017
- Author(s)
  Piao, X. Yamazaki, S. Komazawa-Sakon, S. Miyake, S. Nakabayashi, O. Kurosawa, T. Mikami, T. Tanaka, M. Van Rooijen, N. Ohmuraya, M. Oikawa, A. Kojima, Y. Kakuta, S. Uchiyama, Y. Tanaka, M. Nakano, H.
- Journal Title
  
  Hepatology
  
  Volume: 65 Issue: 1 Pages: 237-252
- DOI
  10.1002/hep.28878
- NAID
  120006528815
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26110003, KAKENHI-PLANNED-26110007, KAKENHI-PROJECT-26460397, KAKENHI-PROJECT-16K01378, KAKENHI-PROJECT-16K08747, KAKENHI-PROJECT-16K09398, KAKENHI-PROJECT-16K15681, KAKENHI-PROJECT-16H00591, KAKENHI-PROJECT-16K08789, KAKENHI-PLANNED-26110006, KAKENHI-PROJECT-17H04068
[Journal Article] IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting.2017
- Author(s)
  Takeda K, Nakayama M, Hayakawa Y, Kojima Y, Ikeda H, Imai N, Ogasawara K, Okumura K, Thomas DM, Smyth MJ
- Journal Title
  
  Nat Commun.
  
  Volume: 8 Issue: 1 Pages: 14607-14607
- DOI
  10.1038/ncomms14607
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06497, KAKENHI-PROJECT-15H04918, KAKENHI-PROJECT-16H02960, KAKENHI-PROJECT-16H05530, KAKENHI-PROJECT-26460397, KAKENHI-PROJECT-15K14410, KAKENHI-PROJECT-16K15112
[Journal Article] Critical contribution of nuclear factor erythroid 2-related factor 2 (NRF2) to electrophile-induced Interleukin-11 production.2017
- Author(s)
  Nishina T, Deguchi Y, Miura R, Yamazaki S, Shinkai Y, Kojima Y, Okumura K, Kumagai Y, Nakano H.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Issue: 1 Pages: 205-216
- DOI
  10.1074/jbc.m116.744755
- NAID
  120007135104
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01392, KAKENHI-PLANNED-26110003, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-26460397, KAKENHI-PROJECT-16K01378, KAKENHI-PROJECT-16K08747, KAKENHI-PROJECT-16K15681
[Journal Article] Development of Accelerated Coronary Atherosclerosis Model Using Low Density Lipoprotein Receptor Knock-Out Swine with Balloon Injury.2016
- Author(s)
  Ogita M, Miyauchi K, Onishi A, Tsuboi S, Wada H, Konishi H, Naito R, Dohi T, Kasai T, Kojima Y, Schwartz RS, Daida H.
- Journal Title
  
  PLoS One.
  
  Volume: 11 Issue: 9 Pages: e0163055-e0163055
- DOI
  10.1371/journal.pone.0163055
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460397
[Journal Article] TIM-4 has dual function in the induction and effector phases of murine arthritis.2013
- Author(s)
  Abe Y, Kamachi F, Kawamoto T, Makino F, Ito J, Kojima Y, Moustapha Ael D, Usui Y, Yagita H, Takasaki Y, Okumura K, Akiba H.
- Journal Title
  
  J Immunol
  
  Volume: 191 Pages: 4562-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390260
[Journal Article] TIM-4 has dual function in the induction and effector phases of murine arthritis2013
- Author(s)
  Abe Y, Kamachi F, Kawamoto T, Makino F, Ito J, Kojima Y, Moustapha Ael D, Usui Y, Yagita H, Takasaki Y, Okumura K, Akiba H
- Journal Title
  
  Journal of Immunology
  
  Volume: 191巻 Issue: 9 Pages: 4562-4572
- DOI
  10.4049/jimmunol.1203035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J10815, KAKENHI-PROJECT-23390260, KAKENHI-PROJECT-25461503
[Journal Article] Anti-TIM-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells2011
- Author(s)
  Kawamoto T, Abe Y, Ito J, Makino F, Kojima Y, Usui Y, Ma J, Morimoto S, Yagita H, Okumura K, Takasaki Y, Akiba H
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 13 Issue: 2
- DOI
  10.1186/ar3288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591098, KAKENHI-PROJECT-23390260
[Journal Article] Crucial role for autophagy in degranulation of mast cells2011
- Author(s)
  Ushio, et al
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 127 Issue: 5 Pages: 1267-1276
- DOI
  10.1016/j.jaci.2010.12.1078
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23117717, KAKENHI-PROJECT-23390260, KAKENHI-PROJECT-23590576, KAKENHI-PROJECT-23659404
[Journal Article] Importin β1 protein-mediated nuclear localization of death receptor 5 (DR5) limits DR5/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced cell death of human tumor cells2011
- Author(s)
  Kojima Y, Nakayama M, Nishina T, Nakano H, Koyanagi M, Takeda K, Okumura K, Yagita H
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Issue: 50 Pages: 43383-43393
- DOI
  10.1074/jbc.m111.309377
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089, KAKENHI-PUBLICLY-23112519, KAKENHI-PUBLICLY-23117717, KAKENHI-PROJECT-23300355, KAKENHI-PROJECT-23390260, KAKENHI-PROJECT-23659404
[Journal Article]2008
- Author(s)
  Takeda K, Kojima Y, Ikejima K, Harada K, Yamashina S, Okumura K, Aoyama T, Fress S, Ikeda H, Hynes NM, Cretney E, Yagita H, Sueyoshi N, Sato N, Nakanuma Y, Smyth MJ, Okumura K
- Journal Title
  
  Proc Natl Sci USA 105(31)
  
  Pages: 10895-10900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590257
[Journal Article] Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease.2008
- Author(s)
  Takeda K, Kojima Y, Ikejima K, Harada K, Yamashina S, Okumura K, Aoyama T, Frese s, Ikeda H, Hynes NM, Cretney E, Yagita H, Sueyoshi N, Sato N, Nakanuma Y, Smyth MJ, Okumura K
- Journal Title
  
  Proc Natl Acad Sci U S A 105(31)
  
  Pages: 10895-10900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590257
[Presentation] Importin β1 inhibition augments anticancer effect of anti-DR5 agonistic antibody in TRAIL resistant tumor cells2019
- Author(s)
  Yuko Kojima, Takashi Nishina, Hiroyasu Nakano, Ko Okumura, Kazuyoshi Takeda
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07648
[Presentation] 親電子リガンドによるIL-11産生機構とその生体における役割の解明2017
- Author(s)
  仁科隆史、出口裕、三浦亮介、新開泰弘、小島裕子、奥村康、熊谷嘉人、中野裕康
- Organizer
  第44回日本毒性学会学術年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2017-07-12
- Data Source
  KAKENHI-PROJECT-26460397
[Presentation] Analysis of Interleukin-11-producing cells in a colitis-associated cancer model using IL-11 reporter mice2017
- Author(s)
  Takashi Nishina, Yutaka Deguchi, Eri Nakamura, Yuko Kojima, Norihiro Tada, Hiroyasu Nakano
- Organizer
  Keystone Symposia on Molecular and Cellular Biology
- Place of Presentation
  Keystone, Colorado, USA
- Year and Date
  2017-02-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460397
[Presentation] 親電子リガンドによるIL-11産生機構とその生体における役割の解明2016
- Author(s)
  仁科隆史、出口裕、三浦亮介、新開泰弘、小島裕子、熊谷嘉人、中野裕康
- Organizer
  第89回日本生化学大会
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26460397
[Presentation] がん細胞特異的細胞死誘導分子の局在に着目した分子標的がん治療の新たな展開2015
- Author(s)
  小島裕子, 仁科隆史, 中野裕康, 八木田秀雄, 竹田和由
- Organizer
  第38回　日本分子生物学会大会第88回　日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド　（兵庫県神戸市）
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-26460397
[Presentation] インターロイキン（IL）-11を介した生体の恒常性維持機構の解析2015
- Author(s)
  仁科隆史, 出口裕, 大塚正人, 中村衣里, 小島裕子, 多田昇弘, 中野裕康
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  あわぎんホール　（徳島県徳島市）
- Year and Date
  2015-06-24
- Invited
- Data Source
  KAKENHI-PROJECT-26460397
[Presentation] 大腸がんの発症と進行におけるInterleukin-11の産生細胞の免疫組織化学的解析2015
- Author(s)
  出口裕, 仁科隆史, 大塚正人, 中村衣里, 小島裕子, 三上哲夫, 多田昇弘, 中野裕康
- Organizer
  第38回　日本分子生物学会大会第88回　日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド　（兵庫県神戸市）
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-26460397
[Presentation] インターロイキン(IL)-11レポ-ターマウスを用いた炎症性大腸発がんモデルにおけるIL-11産生細胞の解析2015
- Author(s)
  仁科隆史, 出口裕, 大塚正人, 中村衣里, 小島裕子, 三上哲夫, 多田昇弘, 中野裕康
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド　（兵庫県神戸市）
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-26460397
[Presentation] Anti-TIM-4 mAb ameliorates allergic lung inflammation by inhibiting TIM-4-mediated mast cell stimulation2013
- Author(s)
  F. Kamachi, M. Hara, N. Harada, Y. Katsura, Y. Kojima, K. Izawa, C. Nishiyama, K. Okumura, H. Akiba
- Organizer
  15th International Congress of Immunology
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-23390260
[Presentation]2008
- Author(s)
  Takeda K, Kojima Y, Yagita H, Smyth MJ, Okumura K
- Organizer
  第38回日本免疫学会
- Place of Presentation
  京都国際会議場
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-19590257
[Presentation]2008
- Author(s)
  Kojima Y, Takeda K, Yagita H, Smyth MJ, Okumura K
- Organizer
  第38回日本免疫学会
- Place of Presentation
  京都国際会議場
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-19590257

1. OKUMURA Ko (50009700)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. AKIBA Hisaya (60338316)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. YAGITA Hideo (30182306)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. TAKEDA Kazuyoshi (80272821)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. NAKANO Hiroyasu (70276476)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. NISHINA Takashi (50598365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
7. 出口裕 (10287526)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. HARADA Kenichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. KAMACHI Fumitaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HARADA Norihiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. ABE Yoshiyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ISSHIKI Takuma

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. OHMURAYA Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. PIAO Xuehua

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 小笠原康悦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 熊谷嘉人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kojima Yuko 小島 裕子

小島 裕子 コジマ ユウコ

KOJIMA Yuko 小島 裕子

Research Projects

Research Products

Co-Researchers

Regulation mechanism of apoptosis-inducing death receptor localization allowing for survival in tumor cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of mucosal repair mechanism mediated by interleukin 11 in inflammatory bowel disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Immune regulation on autoimmune and allergic diseases by the TIM family molecules

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A new cancer therapy by intracellular localization control of apoptosis inducing death receptor in tumor cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the antibody medical treatment to autoimmune and asthmatic diseases based on new target molecule.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Contribution of intracellular TRAIL receptor to regulation of apoptosis induced by TRAILPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Inhibition of Importin β1 Augments the Anticancer Effect of Agonistic Anti-Death Receptor 5 Antibody in TRAIL-Resistant Tumor Cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Depletion of myeloid cells exacerbates hepatitis and induces an aberrant increase in histone H3 in mouse serum2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Critical contribution of nuclear factor erythroid 2-related factor 2 (NRF2) to electrophile-induced Interleukin-11 production.2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Development of Accelerated Coronary Atherosclerosis Model Using Low Density Lipoprotein Receptor Knock-Out Swine with Balloon Injury.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TIM-4 has dual function in the induction and effector phases of murine arthritis.2013

Author(s)

Journal Title

Data Source

[Journal Article] TIM-4 has dual function in the induction and effector phases of murine arthritis2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-TIM-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells2011

Author(s)

Kojima Yuko 小島裕子

小島裕子コジマユウコ

KOJIMA Yuko 小島裕子