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AKIBA Hisaya  秋葉 久弥

ORCIDConnect your ORCID iD *help
… Alternative Names

秋葉 久弥  アキバ ヒサヤ

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Researcher Number 60338316
Other IDs
Affiliation (Current) 2022: 順天堂大学, 大学院医学研究科, 准教授
Affiliation (based on the past Project Information) *help 2022: 順天堂大学, 大学院医学研究科, 准教授
2020 – 2021: 順天堂大学, 医学(系)研究科(研究院), 准教授
2012 – 2018: 順天堂大学, 医学(系)研究科(研究院), 准教授
2016: 順天堂大学, 大学院医学研究科, 准教授
2012 – 2013: 順天堂大学, 医学研究科, 准教授 … More
2007 – 2011: Juntendo University, Immunology, Associate professor
2010: 順天堂大学, 大学院・医学研究科, 准教授
2005 – 2006: Juntendo University, Immunology, Assistant Prof., 医学部, 講師
2002 – 2004: 順天堂大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Collagenous pathology/Allergology / Immunology / Ophthalmology / 膠原病・アレルギー・感染症内科学 / アレルギー / Basic Section 49030:Experimental pathology-related
Except Principal Investigator
膠原病・アレルギー・感染症内科学 / Biological Sciences / Immunology / Experimental pathology / Ophthalmology
Keywords
Principal Investigator
Th1 / Th2 / 補助シグナル分子 / OX40 / OX40L / ICOS / B7RP-1 / 自己免疫疾患 / 喘息 / アレルギー … More / T細胞分化 / アレルギー疾患 / CXCR5 / 免疫 / 炎症 / 診断薬 / 免疫学 / 樹状細胞 / T細胞分化・制御 / 実験的自己免疫性ぶどう膜網膜炎 / EAU / OX40-OX40L / Th1/Th2 / 喘息モデルマウス / 関節炎モデルマウス / TIM-4 / 関節炎マウス / CD70-CD27 / コラーゲン誘発性関節炎マウス / 抗炎症作用 / 細胞表面分子機能 / 細胞表面分子 / モノクローナル抗体 / Tim / Tim ligand / Tim family / 喘息疾患 / T cell differentiation / monoclonal antibody / ぜんそく / アレルギー・ぜんそく … More
Except Principal Investigator
アポトーシス / Tim-3 / コラーゲン誘発性関節炎 / 自己免疫疾患 / CD8α^+樹状細胞 / トレランス / TRAIL / DR5 / histone deacetylase inhibitor / 原発性硬化性胆管炎(PSC) / ErbB-2(HER2) / TIMファミリー / マスト細胞 / アレルギー / T cell immunoglobulin and mucin domain (TIM)ファミリー / TIM-2 / B細胞 / T細胞 / Th1細胞 / Th2細胞 / Th17細胞 / オートファジー / インターフェロン / Liht chain(LC)3 / ノックアウトマウス / 脱顆粒 / IgE / CD63 / 樹状細胞 / 貪食 / クロスプレゼンテーション / 免疫監視 / 腫瘍免疫 / 癌治療 / 細胞死 / 免疫活性化 / 免疫抑制 / regulatory T細胞 / 所属リンパ節 / CTL / CTLA-4 / C-ERC / mesotheli / ADCC / 中皮腫 / NK細胞 / CD40 / CD137 / IL-15 / Erb-2 / HER2 / bortezomib / 関節リウマチ / 抗体療法 / 喘息 / アレルギー・喘息 / アレルギー・喘息 / TIM-4 / 抗炎症作用 / 免疫学 / アレルギー疾患 / 炎症 / アレルギー・ぜんそく / 関節炎モデル / 実験的自己免疫性ぶどう膜網膜炎 / OVA誘発性喘息 / 実験的自己免疫性脳脊髄炎 / 補助シグナル分子 / CD28-B7ファミリー / TNF-TNFRファミリー / B7RP-1 / TWEAK / autoimmune diseases / collagen-induced arthritis / experimental autoimmune uveoretinitis / murine model of asthma / experimental autoimmune encephalomyelitis / costimulatory molecules / CD28-B7 family / TNF-TNFR family / 免疫特権 / 副刺激シグナル / 移植免疫応答 / ICOS/B7RP-1(ICOSL) / VISTAシグナル / ICOS/B7RP-1 Less
  • Research Projects

    (14 results)
  • Research Products

    (129 results)
  • Co-Researchers

    (48 People)
  •  自己免疫疾患・アレルギー疾患の病態を制御するTIM分子の機能解明Principal Investigator

    • Principal Investigator
      秋葉 久弥
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      Juntendo University
  •  Detection of human TIM-4 on autoimmune and allergic diseasesPrincipal Investigator

    • Principal Investigator
      Akiba Hisaya
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Collagenous pathology/Allergology
    • Research Institution
      Juntendo University
  •  Immune regulation on autoimmune and allergic diseases by the TIM family molecules

    • Principal Investigator
      Okumura Ko
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Juntendo University
  •  Immune regulation for tissue transplantation and regeneration in the eye

    • Principal Investigator
      Hori Junko
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Nippon Medical School
  •  Analysis of therapeutic effect of anti-TIM-4 mAb on inflammatory disease.Principal Investigator

    • Principal Investigator
      Akiba Hisaya
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Collagenous pathology/Allergology
    • Research Institution
      Juntendo University
  •  Development of the antibody medical treatment to autoimmune and asthmatic diseases based on new target molecule.

    • Principal Investigator
      OKUMURA Ko
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Juntendo University
  •  A classification and identification of the asthmatic disease-inducedCD4 T cell subset with costimulatory molecule markerPrincipal Investigator

    • Principal Investigator
      AKIBA Hisaya
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Juntendo University
  •  免疫による癌拒絶局所での分子機構の解析

    • Principal Investigator
      KAZUYOSHI Takeda
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Juntendo University
  •  Development of strategy to treat allergic diseases via targeting surface molecules on lymphocytes and intracellular signaling molecules

    • Principal Investigator
      OKUMURA Ko
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Juntendo University
  •  Development of novel cancer therapy by combination of immune activation with tumor apoptosis induction

    • Principal Investigator
      KAZUYOSHI Takeda
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Juntendo University
  •  Functional analysis of costimulatory molecules in autoimmune uveitis and their intervention for clinical applicationPrincipal Investigator

    • Principal Investigator
      AKIBA Hisaya
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Juntendo University
  •  Functional analysis of costimulatory molecules for autoimmune diseases

    • Principal Investigator
      OKUMURA Ko
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Juntendo University
  •  Identification of Th cells in vivo and analysis of differentiation and function of Th2 cells by costimulatory moleculesPrincipal Investigator

    • Principal Investigator
      AKIBA Hisaya
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      アレルギー
    • Research Institution
      JUNTENDO UNIVERSITY
  •  Th2細胞の分化・機能に関わる補助シグナル分子の解明Principal Investigator

    • Principal Investigator
      秋葉 久弥
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Immunology
    • Research Institution
      Juntendo University

All 2021 2020 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation

  • [Journal Article] Blockade of costimulatory CD27/CD70 pathway promotes corneal allograft survival.2021

    • Author(s)
      Narimatsu A, Hattori T, Hiroki Ueno et al
    • Journal Title

      Experimental Eye Research

      Volume: 199 Pages: 108190-108190

    • DOI

      10.1016/j.exer.2020.108190

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K09463, KAKENHI-PROJECT-19K09959, KAKENHI-PROJECT-20H03472, KAKENHI-PROJECT-19K18892
  • [Journal Article] ImmunoPET Imaging of TIM-3 in Murine Melanoma Models.2020

    • Author(s)
      Wei W, Jiang D, Lee HJ, Engle JW, Akiba H, Liu J, Cai W.
    • Journal Title

      Adv Ther

      Volume: 3 Pages: 2000018-2000018

    • DOI

      10.1002/adtp.202000018

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03472
  • [Journal Article] Combination of TWEAK and TGF-β1 induces the production of TSLP, RANTES, and TARC in BEAS-2B human bronchial epithelial cells during epithelial-mesenchymal transition2018

    • Author(s)
      Matsuno Kei、Harada Norihiro、Harada Sonoko、Takeshige Tomohito、Ishimori Ayako、Itoigawa Yukinari、Katsura Yoko、Kodama Yuzo、Makino Fumihiko、Ito Jun、Atsuta Ryo、Akiba Hisaya、Takahashi Kazuhisa
    • Journal Title

      Exp Lung Res

      Volume: 44 Pages: 332-343

    • DOI

      10.1080/01902148.2018.1522558

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09554, KAKENHI-PROJECT-16K09587, KAKENHI-PROJECT-16K09924
  • [Journal Article] Characterization of tenascin-C as a novel biomarker for asthma: utility of tenascin-C in combination with periostin or immunoglobulin E2018

    • Author(s)
      Yasuda Mina、Harada Norihiro、Harada Sonoko、Ishimori Ayako、Katsura Yoko、Itoigawa Yukinari、Matsuno Kei、Makino Fumihiko、Ito Jun、Ono Junya、Tobino Kazunori、Akiba Hisaya、Atsuta Ryo、Izuhara Kenji、Takahashi Kazuhisa
    • Journal Title

      Allergy Asthma Clin Immunol

      Volume: 14 Pages: 72-72

    • DOI

      10.1186/s13223-018-0300-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05343, KAKENHI-PROJECT-16K09554, KAKENHI-PROJECT-16K09587, KAKENHI-PROJECT-16K09924
  • [Journal Article] Cutting Edge: Anti-TIM-3 Treatment Exacerbates Pulmonary Inflammation and Fibrosis in Mice2017

    • Author(s)
      Isshiki T, Akiba H, Nakayama M, Harada N, Okumura K, Homma S, Miyake S.
    • Journal Title

      J Immunol

      Volume: 199 Pages: 3733-3737

    • DOI

      10.4049/jimmunol.1700059

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09554, KAKENHI-PROJECT-16K09587, KAKENHI-PROJECT-16H02960, KAKENHI-PROJECT-17H04218, KAKENHI-PROJECT-16K15112, KAKENHI-PROJECT-16K09924
  • [Journal Article] Protective Role of ICOS and ICOS Ligand in Corneal Transplantation and in Maintenance of Immune Privilege.2016

    • Author(s)
      Kunishige T, Taniguchi H, Terada M, Akiba H, Yagita H, Abe R, Hori J
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 57(15) Pages: 6815-6823

    • DOI

      10.1167/iovs.16-20644

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26462700, KAKENHI-PROJECT-15K20290, KAKENHI-PROJECT-16K09924
  • [Journal Article] OX40L blockade protects against inflammation-driven fibrosis.2016

    • Author(s)
      Elhai M, Avouac J, Hoffmann-Vold AM, Ruzehaji N, Amiar O, Ruiz B, Brahiti H, Ponsoye M, Frechet M, Burgevin A, Pezet S, Sadoine J, Guilbert T, Nicco C, Akiba H, Heissmeyer V, Subramaniam A, Resnick R, Molberg O, Kahan A, Chiocchia G, Allanore Y.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 113

    • DOI

      10.1073/pnas.1523512113

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09924
  • [Journal Article] ICOS promotes group 2 innate lymphoid cell activation in lungs.2015

    • Author(s)
      Kamachi F, Isshiki T, Harada N, Akiba H, Miyake S
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 463 Pages: 739-745

    • DOI

      10.1016/j.bbrc.2015.06.005

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K19031, KAKENHI-PROJECT-25461167, KAKENHI-PROJECT-25461503, KAKENHI-PROJECT-26293234
  • [Journal Article] Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells.2015

    • Author(s)
      Tripathi S, Chabtini L, Dakle PJ, Smith B, Akiba H, Yagita H, Guleria I.
    • Journal Title

      PLoS One.

      Volume: 10

    • DOI

      10.1371/journal.pone.0123439

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25461503
  • [Journal Article] Characteristics of alveolar macrophages from murine models of OVA-induced allergic airway inflammation and LPS-induced acute airway inflammation.2015

    • Author(s)
      1)Katsura Y, Harada N, Harada S, Ishimori A, Makino F, Ito J, Kamachi F, Okumura K, Akiba H, Atsuta R, Takahashi K
    • Journal Title

      Exp Lung Res

      Volume: 41 Pages: 370-382

    • DOI

      10.3109/01902148.2015.1044137

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K19031, KAKENHI-PROJECT-25461167, KAKENHI-PROJECT-25461503, KAKENHI-PROJECT-26293087
  • [Journal Article] OX40 ligand regulates splenic CD8⁻ dendritic cell-induced Th2 responses in vivo.2014

    • Author(s)
      Kamachi F, Harada N, Usui Y, Sakanishi T, Ishii N, Okumura K, Miyake S, Akiba H
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 444 Pages: 235-240

    • DOI

      10.1016/j.bbrc.2014.01.060

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-13J10815, KAKENHI-PROJECT-23390261, KAKENHI-PROJECT-24390118, KAKENHI-PROJECT-24659487, KAKENHI-PROJECT-25461167, KAKENHI-PROJECT-25461503, KAKENHI-PROJECT-26293087
  • [Journal Article] Endogenous Tim-1 promotes severe systemic autoimmunity and renal disease MRL-Fas(lpr) mice.2014

    • Author(s)
      Nozaki Y, Kitching AR, Akiba H, Yagita H, Kinoshita K, Funauchi M, Matsumura I.
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 306

    • DOI

      10.1152/ajprenal.00570.2013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461503
  • [Journal Article] The TIM-3 pathway ameliorates Theiler's murine encephalomyelitis virus-induced demyelinating disease.2014

    • Author(s)
      Kaneyama T, Tomiki H, Tsugane S, Inaba Y, Ichikawa M, Akiba H, Yagita H, Kim BS, Koh CS.
    • Journal Title

      Int Immunol

      Volume: 26 Pages: 369-81

    • DOI

      10.1093/intimm/dxt056

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461503
  • [Journal Article] TIM-4 has dual function in the induction and effector phases of murine arthritis.2013

    • Author(s)
      Abe Y, Kamachi F, Kawamoto T, Makino F, Ito J, Kojima Y, Moustapha Ael D, Usui Y, Yagita H, Takasaki Y, Okumura K, Akiba H.
    • Journal Title

      J Immunol

      Volume: 191 Pages: 4562-72

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390260
  • [Journal Article] TIM-3 regulates innate immune cells to induce fetomaternal tolerance.2013

    • Author(s)
      Chabtini L, Mfarrej B, Mounayar M, Zhu B, Batal I, Dakle PJ, Smith BD, Boenisch O, Najafian N, Akiba H, Yagita H, Guleria I.
    • Journal Title

      J Immunol

      Volume: 190 Pages: 88-96

    • DOI

      10.4049/jimmunol.1202176

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461503
  • [Journal Article] T-cell immunoglobulin and mucin domain 3 acts as a negative regulator of atherosclerosis.2013

    • Author(s)
      Foks AC, Ran IA, Wasserman L, Frodermann V, Ter Borg MN, de Jager SC, van Santbrink PJ, Yagita H, Akiba H, Bot I, Kuiper J, van Puijvelde GH.
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 33 Pages: 2558-65

    • DOI

      10.1161/atvbaha.113.301879

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461503
  • [Journal Article] Interruption of dendritic cell-mediated TIM-4 signaling induces regulatory T cells and promotes skin allograft survival.2013

    • Author(s)
      Yeung M, McGrath M, Nakayama M, Shimizu T, Boenisch O, Magee CN, Abdoli R, Akiba H, Ueno T, Turka L, and Najafian N
    • Journal Title

      J Immunol

      Volume: 191 Pages: 4447-4455

    • DOI

      10.4049/jimmunol.1300992

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590158, KAKENHI-PUBLICLY-25118703, KAKENHI-PROJECT-25461503
  • [Journal Article] TIM-4 has dual function in the induction and effector phases of murine arthritis.2013

    • Author(s)
      Abe Y, Kamachi F, Kawamoto T, Makino F, Ito J, Kojima Y, Moustapha Ael D, Usui Y, Yagita H, Takasaki Y, Okumura K, Akiba H
    • Journal Title

      J Immunol

      Volume: 191巻 Pages: 4562-4572

    • DOI

      10.4049/jimmunol.1203035

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-13J10815, KAKENHI-PROJECT-23390260, KAKENHI-PROJECT-25461503
  • [Journal Article] TIM-4 glycoprotein-mediated degradation of dying tumor cells by autophagy leads to reduced antigen presentation and increased immune tolerance2013

    • Author(s)
      Baghdadi M, Yoneda A, Yamashina T, Nagao H, Komohara Y, Nagai S, Akiba H, Foretz M, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Takeya M, Viollet B, Yagita H, Jinushi M
    • Journal Title

      Immunity

      Volume: 39 Pages: 1070-1081

    • DOI

      10.1016/j.immuni.2013.09.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23130501, KAKENHI-PROJECT-23501283, KAKENHI-PROJECT-23590534, KAKENHI-PROJECT-23591132, KAKENHI-PROJECT-24790479, KAKENHI-PUBLICLY-25112701, KAKENHI-PUBLICLY-25130701, KAKENHI-PROJECT-25293089, KAKENHI-PROJECT-25461503
  • [Journal Article] Combined blockade of TIM-3 and TIM-4 augments cancer vaccine efficacy against established melanomas.2013

    • Author(s)
      Baghdadi M, Nagao H, Yoshiyama H, Akiba H, Yagita H, Dosaka-Akita H, Jinushi M
    • Journal Title

      Cancer Immunology, Immunotherapy

      Volume: 62 Pages: 629-37

    • DOI

      10.1007/s00262-012-1371-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089, KAKENHI-PUBLICLY-23130501, KAKENHI-PROJECT-23501283, KAKENHI-PROJECT-23590534, KAKENHI-PUBLICLY-25112701, KAKENHI-PUBLICLY-25130701, KAKENHI-PROJECT-25461503
  • [Journal Article] Galectin-9-mediated protection from allo-specific T cells as a mechanism of immune privilege of corneal allografts.2013

    • Author(s)
      Shimmura-Tomita M, Wang M, Taniguchi H, Akiba H, Yagita H, Hori J
    • Journal Title

      PLoS One

      Volume: 8(5)

    • DOI

      10.1371/journal.pone.0063620

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592619, KAKENHI-PROJECT-25461503
  • [Journal Article] Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses.2013

    • Author(s)
      Takahashi N, Imanishi K, Uchiyama T
    • Journal Title

      Immunity

      Volume: 57 Pages: 584-598

    • DOI

      10.1016/j.immuni.2013.06.019

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-22390215, KAKENHI-PROJECT-23591412, KAKENHI-PROJECT-25461503
  • [Journal Article] Blockade of CD70-CD27 interaction inhibits induction of allergic lung inflammation in mice.2012

    • Author(s)
      Makino F, Ito J, Abe Y, Harada N, Kamachi F, Yagita H, Takahashi K, Okumura K, Akiba H
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 47 Pages: 298-305

    • DOI

      10.1165/rcmb.2011-0354oc

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591098, KAKENHI-PROJECT-23390260
  • [Journal Article] TIM-1 signaling in B cells regulates antibody production2012

    • Author(s)
      Ma J, Usui Y, Takeda K, Harada N, Yagita H, Okumura K, Akiba H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 406 Pages: 223-228

    • DOI

      10.1016/j.bbrc.2011.02.021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591098, KAKENHI-PROJECT-23390260
  • [Journal Article] Galectin-9 and T cell immunoglobulin mucin-3 pathway is a therapeutic target for type 1 diabetes2012

    • Author(s)
      Kanzaki M
    • Journal Title

      Endocrinology.

      Volume: 153(2) Pages: 612-20

    • DOI

      10.1210/en.2011-1579

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249053, KAKENHI-PROJECT-22591098, KAKENHI-PROJECT-23390241, KAKENHI-PROJECT-23659470, KAKENHI-PROJECT-24790926, KAKENHI-PUBLICLY-23126516
  • [Journal Article] Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1.2012

    • Author(s)
      Chiba, M. Baghdadi, H. Akiba, H. Yoshiyama, I. Kinoshita, H. Dosaka-Akita, Y. Fujioka, Y. Ohba, J. V. Gorman, J. D. Colgan, M. Hirashima, T. Uede, A. Takaoka, H. Yagita and M. Jinushi.
    • Journal Title

      Nature Immunology

      Volume: 13 Pages: 832-42

    • DOI

      10.1038/ni.2376

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J04616, KAKENHI-PROJECT-21390113, KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-22590360, KAKENHI-PROJECT-22591098, KAKENHI-PROJECT-23390090, KAKENHI-PROJECT-23501283, KAKENHI-PROJECT-23590534, KAKENHI-PROJECT-23591132, KAKENHI-PROJECT-23659196, KAKENHI-PUBLICLY-23114501
  • [Journal Article] Antibodies Against B7-DC with Differential Binding Properties Exert Opposite Effects2012

    • Author(s)
      Ritprajak P, Hashiguchi M, Akiba H, Yagita H, Okumura K, Azuma M
    • Journal Title

      HYBRIDOMA

      Volume: 31 Pages: 40-47

    • DOI

      10.1089/hyb.2011.0087

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-22021016, KAKENHI-PROJECT-22591098, KAKENHI-PROJECT-23249082, KAKENHI-PROJECT-23390260
  • [Journal Article] Expression pattern changes and function of RANKL during mouse lymph node microarchitecture development.2012

    • Author(s)
      Sugiyama, et al.
    • Journal Title

      Int Immunol

      Volume: 24 Pages: 369-378

    • DOI

      10.1093/intimm/dxs002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591375, KAKENHI-PROJECT-22591098, KAKENHI-PROJECT-23390260
  • [Journal Article] Endogenous Tim-1 (Kim-1) promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis.2012

    • Author(s)
      ozaki Y, Nikolic-Paterson DJ, Snelgrove SL, Akiba H, Yagita H,Holdsworth SR, Kitching AR
    • Journal Title

      Kidney Int

      Volume: 81 Pages: 844-55

    • DOI

      10.1038/ki.2011.424

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591098
  • [Journal Article] Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells2011

    • Author(s)
      Kawamoto T, Abe Y, Ito J, Makino F, Kojima Y, Usui Y, Ma J, Morimoto S, Yagita H, Okumura K, Takasaki Y, Akiba H
    • Journal Title

      Arthritis Res Ther

      Volume: 13

    • DOI

      10.1186/ar3288

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591098, KAKENHI-PROJECT-23390260
  • [Journal Article] Wound-induced TGF-b1 and TGF-b2 enhance airway epithelial repair via HB-EGF and TGFa2011

    • Author(s)
      Ito J, Harada N, Nagashima O, Makino F, Usui Y, Yagita H, Okumura K, Dorscheid DR, Atsuta R, Akiba H, Takahashi K
    • Journal Title

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

      Volume: 412 Pages: 109-114

    • DOI

      10.1016/j.bbrc.2011.07.054

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591098, KAKENHI-PROJECT-22790768, KAKENHI-PROJECT-23390260
  • [Journal Article] Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells.2011

    • Author(s)
      Kawamoto T., Y.Abe, J.Ito, F.Makino, Y.Kojima, Y.Usui, J.Ma, S.Morimoto, H.Yagita, K.Okumura, Y.Takasaki, H.Akiba.
    • Journal Title

      Arthritis Res Ther 13(in press)

    • Data Source
      KAKENHI-PROJECT-20390282
  • [Journal Article] Anti-TIM3 antibody promotes T cell IFN-gamma-mediated antitumor immunity and suppresses established tumors2011

    • Author(s)
      Ngiow SF, von Scheidt B, Akiba H, Yagita H, Teng MW, Smyth MJ
    • Journal Title

      Cancer Res

      Volume: 71 Pages: 3540-3551

    • DOI

      10.1158/0008-5472.can-11-0096

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-22591098
  • [Journal Article] Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice2011

    • Author(s)
      Ding Q, Yeung M, Camirand G, Zeng Q, Akiba H, Yagita H, Chalasani G, Sayegh MH, Najafian N, Rothstein DM
    • Journal Title

      J Clin Invest

      Volume: 121 Pages: 3645-3656

    • DOI

      10.1172/jci46274

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591098
  • [Journal Article] Tim-1 promotes cisplatin nephrotoxicity2011

    • Author(s)
      Nozaki Y, Nikolic-Paterson DJ, Yagita H, Akiba H, Holdsworth SR, Kitching AR
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 301

    • DOI

      10.1152/ajprenal.00193.2011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591098
  • [Journal Article] The TIM-1:TIM-4 pathway enhances renal ischemia-reperfusion injury2011

    • Author(s)
      Rong S, Park JK, Kirsch T, Yagita H, Akiba H, Boenisch O, Haller H, Najafian N, Habicht A
    • Journal Title

      J Am Soc Nephrol

      Volume: 22 Pages: 484-495

    • DOI

      10.1681/asn.2010030321

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591098
  • [Journal Article] Expression and function of inducible costimulator on peripheral blood CD4+T cells in Behcet's patients with uveitis: a new activity marker?2010

    • Author(s)
      Usui Y, Takeuchi M, Yamakawa N, Takeuchi A, Kezuka T, Ma J, Matsuda R, Okunuki Y, Akiba H, Goto H
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 51 Pages: 5099-5104

    • DOI

      10.1167/iovs.10-5286

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591098
  • [Journal Article] IM-3: a novel regulatory molecule of alloimmune activation2010

    • Author(s)
      Boenisch O, D'Addio F, Watanabe T, Elyaman W, Magee CN, Yeung MY, Padera RF, Rodig SJ, Murayama T, Tanaka K, Yuan X, Ueno T, Jurisch A, Mfarrej B, Akiba H, Yagita H, Najafian N
    • Journal Title

      J Immunol

      Volume: 185 Pages: 5806-5819

    • DOI

      10.4049/jimmunol.0903435

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591098
  • [Journal Article] The emerging role of T cell immunoglobulin mucin-1 in the mechanism of liver ischemia and reperfusion injury in the mouse.2010

    • Author(s)
      Uchida Y., B.Ke, M.C.Freitas, H.Ji, D.Zhao, E.R.Benjamin, N.Najafian, H.Yagita, H.Akiba, R.W.Busuttil, J.W.Kupiec-Weglinski
    • Journal Title

      Hepatology 51

      Pages: 1363-1372

    • Data Source
      KAKENHI-PROJECT-20390282
  • [Journal Article] TIM-3 : a novel regulatory molecule of alloimmune activation.2010

    • Author(s)
      Boenisch O., F.D'Addio, T.Watanabe, W.Elyaman, C.N.Magee, M.Y.Yeung, R.F.Padera, S.J.Rodig, T.Murayama, K.Tanaka, X.Yuan, T.Ueno, A.Jurisch, B.Mfarrej, H.Akiba, H.Yagita, N.Najafian
    • Journal Title

      J Immunol 185

      Pages: 5806-5819

    • Data Source
      KAKENHI-PROJECT-20390282
  • [Journal Article] The emerging role of TIM-1 in the mechanism of liver ischemia and reperfusion injury in the mouse2010

    • Author(s)
      Uchida Y, Ke B, Freitas MC, Ji H, Zhao D, Benjamin ER, Najafian N, Yagita H, Akiba H, Busuttil RW, Kupiec-Weglinski JW
    • Journal Title

      Hepatolog

      Volume: 51 Pages: 1363-1372

    • DOI

      10.1002/hep.23442

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591098
  • [Journal Article] Contribution of B7RP-1/ICOS co-stimulation to lethal acute GVHD2010

    • Author(s)
      Fujimura J, Takeda K, Kaduka Y, Saito M, Akiba H, Yagita H, Yamashiro Y, Shimizu T, Okumura K
    • Journal Title

      Pediatr Transplant

      Volume: 14 Pages: 540-548

    • DOI

      10.1111/j.1399-3046.2009.01279.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591098
  • [Journal Article] Premature terminal exhaustion of Friend virus-specific effector CD8+ T cells by rapid induction of multiple inhibitory receptors.2010

    • Author(s)
      Takamura S., S.Tsuji-Kawahara, H.Yagita, H.Akiba, M.Sakamoto, T.Chikaishi, M.Kato, M.Miyazawa
    • Journal Title

      J Immunol 184

      Pages: 4696-4707

    • Data Source
      KAKENHI-PROJECT-20390282
  • [Journal Article] T-cell immunoglobulin mucin-3 determines severity of liver ischemia/reperfusion injury in mice in a TLR4-dependent manner.2010

    • Author(s)
      Uchida Y., B.Ke, M.C.Freitas, H.Yagita, H.Akiba, R.W.Busuttil, N.Najafian, J.W.Kupiec-Weglinski
    • Journal Title

      Gastroenterology 139

      Pages: 2195-2206

    • Data Source
      KAKENHI-PROJECT-20390282
  • [Journal Article] TIM1 is an endogenous ligand for LMIR5/CD300b : LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury.2010

    • Author(s)
      Yamanishi Y., J.Kitaura, K.Izawa, A.Kaitani, Y.Komeno, M.Nakamura, S.Yamazaki, Y.Enomoto, T.Oki, H.Akiba, T.Abe, T.Komori, Y.Morikawa, H.Kiyonari, T.Takai, K.Okumura, T.Kitamura
    • Journal Title

      J Exp Med 207

      Pages: 1501-1511

    • Data Source
      KAKENHI-PROJECT-20390282
  • [Journal Article] TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury2010

    • Author(s)
      Yamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T.
    • Journal Title

      J Exp Med

      Volume: 207 Pages: 1501-1511

    • DOI

      10.1084/jem.20090581

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591098
  • [Journal Article] TIM-3 determines severity of liver ischemia/reperfusion injury in mice in a TLR4-dependent manner2010

    • Author(s)
      Uchida Y, Ke B, Freitas MC, Yagita H,Akiba H, Busuttil RW, Najafian N, Kupiec-Weglinski JW
    • Journal Title

      Gastroenterology

      Volume: 139 Pages: 2195-2206

    • DOI

      10.1053/j.gastro.2010.07.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591098
  • [Journal Article] Premature terminal exhaustion of Friend virus-specific effector CD8+T cells by rapid induction of multiple inhibitory receptors2010

    • Author(s)
      Takamura, S., S. Tsuji-Kawahara, H. Yagita, H. Akiba, M. Sakamoto, T. Chikaishi, M. Kato, M. Miyazawa
    • Journal Title

      J Immunol

      Volume: 184 Pages: 4696-4707

    • DOI

      10.4049/jimmunol.0903478

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390143, KAKENHI-PROJECT-22591098
  • [Journal Article] Notch signaling confers antigen-presenting cell functions on mast cells2009

    • Author(s)
      Nakano, N., C. Nishiyama, H. Yagita, A. Koyanagi, H. Akiba, S. Chiba, H. Ogawa, and K. Okumura
    • Journal Title

      J Allergy Clin Immunol 123

      Pages: 74-81

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592040
  • [Journal Article] RANK-RANKL signaling pathway is critically involved in the function of CD4+ CD25+ regulatory T cells in chronic colitis2009

    • Author(s)
      Totsuka, T., T. Kanai, Y. Nemoto, T. Tomita, R. Okamoto, K. Tsuchiya, T. Nakamura, N. Sakamoto, H. Akiba, K. Okumura, H. Yagita, and M. Watanabe.
    • Journal Title

      J Immunol 182

      Pages: 6079-6087

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592040
  • [Journal Article] Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation2009

    • Author(s)
      Nakayama, M., H. Akiba, K. Takeda, Y. Kojima, M. Hashiguchi, M. Azuma, H. Yagita, and K. Okumura
    • Journal Title

      Blood 113

      Pages: 3821-3830

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592040
  • [Journal Article] Notch signaling confers antigen-presenting cell functions on mast cells.2009

    • Author(s)
      Nakano N., C.Nishiyama, H.Yagita, A.Koyanagi, H.Akiba, S.Chiba, H.Ogawa, K.Okumura
    • Journal Title

      J Allergy Clin Immunol 123

    • Data Source
      KAKENHI-PROJECT-20390282
  • [Journal Article] RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis.2009

    • Author(s)
      Totsuka T., T.Kanai, Y.Nemoto, T.Tomita, R.Okamoto, K.Tsuchiya, T.Nakamura, N.Sakamoto, H.Akiba, K.Okumura, H.Yagita, M.Watanabe
    • Journal Title

      J Immunol 182

      Pages: 6079-6087

    • Data Source
      KAKENHI-PROJECT-20390282
  • [Journal Article] Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation.2009

    • Author(s)
      Nakayama M., Akiba H., Takeda K., 他
    • Journal Title

      Blood 113

      Pages: 3821-3830

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590494
  • [Journal Article] RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium.2009

    • Author(s)
      Knoop K.A., N.Kumar, B.R.Butler, S.K.Sakthivel, R.T.Taylor, T.Nochi, H.Akiba, H.Yagita, H.Kiyono, I.R.Williams
    • Journal Title

      J Immunol 183

      Pages: 5738-5747

    • Data Source
      KAKENHI-PROJECT-20390282
  • [Journal Article] Suppression of experimental autoimmune uveoretinitis by regulatory dendritic cells in mice2009

    • Author(s)
      Usui, Y., M. Takeuchi, T. Hattori, Y. Okunuki, K. Nagasawa, T. Kezuka, K. Okumura, H. Yagita, H. Akiba, and H. Goto.
    • Journal Title

      Arch Ophthalmol 127

      Pages: 514-519

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592040
  • [Journal Article] Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation.2009

    • Author(s)
      Nakayama M., H.Akiba, K.Takeda, Y.Kojima, M.Hashiguchi, M.Azuma, H.Yagita, K.Okumura
    • Journal Title

      Blood 113

      Pages: 3821-3830

    • Data Source
      KAKENHI-PROJECT-20390282
  • [Journal Article] Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.2009

    • Author(s)
      Yuan X., M.J.Ansari, F.D'Addio, J.Paez-Cortez, I.Schmitt, M.Donnarumma, O.Boenisch, X.Zhao, J.Popoola, M.R.Clarkson, H.Yagita, H.Akiba, G.J.Freeman, J.Iacomini, L.A.Turka, L.H.Glimcher, M.H.Sayegh
    • Journal Title

      Proc Natl Acad Sci U S A 106

      Pages: 10734-10739

    • Data Source
      KAKENHI-PROJECT-20390282
  • [Journal Article] The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model.2008

    • Author(s)
      Ueno T., A.Habicht, M.R.Clarkson, M.J.Albin, K.Yamaura, O.Boenisch, J.Popoola, Y.Wang, H.Yagita, H.Akiba, M.J.Ansari, J.Yang, L.A.Turka, D.M.Rothstein, R.F.Padera, N.Najafian, M.H.Sayegh
    • Journal Title

      J Clin Invest 118

      Pages: 742-751

    • Data Source
      KAKENHI-PROJECT-20390282
  • [Journal Article] Peritubular ischemia contributes more to tubular damage than proteinuria in immune-mediated glomerulonephritis2008

    • Author(s)
      Wong, M. G., Y. Suzuki, C. Tanifuji, H. Akiba, K. Okumura, T. Sugaya, T. Yamamoto, S. Horikoshi, S. Y. Tan, C. Pollock, and Y. Tomino.
    • Journal Title

      J Am Soc Nephrol 19

      Pages: 290-297

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592040
  • [Journal Article] Roles of galectin-9 in the development of experimental allergic conjunctivitis in mice2008

    • Author(s)
      Fukushima, A., T. Sumi, K. Fukuda, N. Kumagai, T. Nishida, K. Okumura, H. Akiba, H. Yagita, and H. Ueno.
    • Journal Title

      Int Arch Allergy Immunol 146

      Pages: 36-43

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592040
  • [Journal Article] The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model2008

    • Author(s)
      Ueno, T., A. Habicht, M. R. Clarkson, M. J. Albin, K. Yamaura, O. Boenisch, J. Popoola, Y. Wang, H. Yagita, H. Akiba, M. J. Ansari, J. Yang, L. A. Turka, D. M. Rothstein, R. F. Padera, N. Najafian, and M. H. Sayegh
    • Journal Title

      J Clin Invest 118

      Pages: 742-751

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592040
  • [Journal Article] B7-H3 contributes to the development of pathogenic Th2 cells in a murine model of asthma.2008

    • Author(s)
      Nagashima O., N.Harada, Y.Usui, T.Yamazaki, H.Yagita, K.Okumura, K.Takahashi, H.Akiba
    • Journal Title

      J Immunol 181

      Pages: 4062-4071

    • Data Source
      KAKENHI-PROJECT-20390282
  • [Journal Article] B7-H3 contributes to the development of pathogenic Th2 cells in a murine model of asthma2008

    • Author(s)
      Nagashima, O., N. Harada, Y. Usui, T. Yamazaki, H. Yagita, K. Okumura, K. Takahashi, and H. Akiba
    • Journal Title

      J Immunol 181

      Pages: 4062-4071

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592040
  • [Journal Article] A novel ICOS-independent, but CD28- and SAP-dependent, pathway of T cell-dependent, polysaccharide specific humoral immunity in response to intact Streptococcus pneumoniae versus pneumococcal conjugate vaccine2008

    • Author(s)
      Chen, Q., J. L. Cannons, J. C. Paton, H. Akiba, P. L. Schwartzberg, and C. M. Snapper
    • Journal Title

      J Immunol 181

      Pages: 8258-8266

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592040
  • [Journal Article] Antibodies to T-cell Ig and mucin domain-containing proteins(Tim)-1 and -3 suppress the induction and progression of murine allergic conjunctivitis2007

    • Author(s)
      Fukushima, A., T., Sumi, K., Fukuda, N., Kumagai, T., Nishida, H., Akiba, K., Okumura, H., Yagita, H., Ueno
    • Journal Title

      Biochemical and biophysical research communications 353

      Pages: 211-216

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] Antibodies to T-cell Ig and mucin domain-containing proteins (Tim)-1 and -3 suppress the induction and progression of murine allergic conjunctivitis2007

    • Author(s)
      Fukushima, A., T. Sumi, K. Fukuda, N. Kumagai, T. Nishida, H. Akiba, K. Okumura, H. Yagita, and H. Ueno
    • Journal Title

      Biochem Biophys Res Commun 353

      Pages: 211-216

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592040
  • [Journal Article] T-cell Ig and mucin domain-containing protein (Tim)-2 regulates murine allergic conjunctivitis during the effector phase2007

    • Author(s)
      Fukushima, A., T. Sumi, K. Fukuda, N. Kumagai, T. Nishida, K. Okumura, H. Akiba, H. Yagita, and H. Ueno
    • Journal Title

      Immunol Lett 110

      Pages: 133-138

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592040
  • [Journal Article] T-cell Ig and mucin domain-containing protein(Tim)-2 regulates murine allergic conjunctivitis during the effector phase2007

    • Author(s)
      Fukushima, A., T., Sumi, K., Fukuda, N., Kumagai, T., Nishida, K., Okumura, H., Akiba, H., Yagita, H., Ueno
    • Journal Title

      Immunology letters 110

      Pages: 133-138

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] Blockade of the OX40ligand prolongs corneal allograft survival2007

    • Author(s)
      Hattori, T., Y., Usui, Y., Okunuki, Y., Sonoda, M., Usui, E., Takada, J., Mizuguchi, H., Yagita, K., Okumura, H., Akiba, M., Takeuchi
    • Journal Title

      European journal of immunology 37

      Pages: 3597-3604

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] Blockade of the OX40 ligand prolongs corneal allograft survival2007

    • Author(s)
      Hattori, T., Y. Usui, Y. Okunuki, Y. Sonoda, M. Usui, E. Takada, J. Mizuguchi, H. Yagita, K. Okumura, H. Akiba, and M. Takeuchi
    • Journal Title

      Eur J Immunol 37

      Pages: 3597-3604

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592040
  • [Journal Article] B7-H3 regulates the development of experimental allergic conjunctivitis in mice2007

    • Author(s)
      Fukushima, A., T., Sumi, K., Fukuda, N., Kumagai, T., Nishida, T., Yamazaki, H., Akiba, K., Okumura, H., Yagita, H., Ueno
    • Journal Title

      Immunology letters 113

      Pages: 52-57

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells2007

    • Author(s)
      Nakae, S., M. Iikura, H. Suto, H. Akiba, D. T. Umetsu, R. H. Dekruyff, H. Saito, and S. J. Galli
    • Journal Title

      Blood 110

      Pages: 2565-2568

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592040
  • [Journal Article] Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function2007

    • Author(s)
      Xiao, S., N. Najafian, J. Reddy, M. Albin, C. Zhu, E. Jensen, J. Imitola, T. Korn, A. C. Anderson, Z. Zhang, C. Gutierrez, T. Moll, R. A. Sobel, D. T. Umetsu, H. Yagita, H. Akiba, T. Strom, M. H. Sayegh, R. H. DeKruyff, S. J. Khoury, and V. K. Kuchroo
    • Journal Title

      J Exp Med 204

      Pages: 1691-1702

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592040
  • [Journal Article] B7-H3 regulates the development of experimental allergic conjunctivitis in mice2007

    • Author(s)
      Fukushima, A., T. Sumi, K. Fukuda, N. Kumagai, T. Nishida, T. Yamazaki, H. Akiba, K. Okumura, H. Yagita, and H. Ueno
    • Journal Title

      Immunol Lett 113

      Pages: 52-57

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592040
  • [Journal Article] Preferential involvement of Tim-3 in the regulation of hepatic CD8+ T cells in murine acute graft-versus-host disease2006

    • Author(s)
      Oikawa, T., Y., Kamimura, H., Akiba, H., Yagita, K., Okumura, H., Takahashi, M., Zeniya, H., Tajiri, M., Azuma
    • Journal Title

      J lmmuno 1177

      Pages: 4281-4287

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] 2006. Eradication of established tumors in mice by a combination antibody-based therapy2006

    • Author(s)
      Uno, T., K., Takeda, Y., Kojima, H., Yoshizawa, H., Akiba, R. S., Mittler, F., Gejyo, K., Okumura, H., Yagita, M. J., Smyth
    • Journal Title

      Nature medicine 12

      Pages: 693-698

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibody2006

    • Author(s)
      Kamijo, S., A., Nakajima, K., Ikeda, K., Aoki, K., Ohya, H., Akiba, H., Yagita, K., Okumura
    • Journal Title

      Biochemical and biophysical research communications 347

      Pages: 124-132

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p1 to sensitization toward IgE and IgG responses2006

    • Author(s)
      Kikuchi, Y., T., Takai, T., Kuhara, M., Ota, T., Kato, H., Hatanaka, S., Ichikawa, T., Tokura, H., Akiba, K., Mitsuishi, S., Ikeda, K., Okumura, H., Ogawa
    • Journal Title

      J lmmunol 177

      Pages: 1609-1617

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Journal Article] TIMファミリー分子2005

    • Author(s)
      秋葉 久弥
    • Journal Title

      炎症と免疫 13

      Pages: 34-40

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16616008
  • [Journal Article] The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo.2005

    • Author(s)
      Akiba, H., K.Takeda, Y.Kojima, Y.Usui, N.Harada, T.Yamazaki, J.Ma, K.Tezuka, H.Yagita, K.Okumura.
    • Journal Title

      J Immunol 175

      Pages: 2340-2348

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16616008
  • [Journal Article] IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2.2005

    • Author(s)
      Ota, T., K.Takeda, H.Akiba, Y.Hayakawa, K.Ogasawara, Y.Ikarashi, S.Miyake, H.Wakasugi, T.Yamamura, M.Kronenberg, D.H.Raulet, K.Kinoshita, H.Yagita, M.J.Smyth, K.Okumura.
    • Journal Title

      Blood 106

      Pages: 184-192

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16616008
  • [Journal Article] TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver.2005

    • Author(s)
      Takeda, K., E.Cretney, Y.Hayakawa, T.Ota, H.Akiba, K.Ogasawara, H.Yagita, K.Kinoshita, K.Okumura, M.J.Smyth.
    • Journal Title

      Blood 105

      Pages: 2082-2089

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16616008
  • [Journal Article] Immune responses against a single CD8+-T-cell epitope induced by virus vector vaccination can successfully control Trypanosoma cruzi infection.2005

    • Author(s)
      Miyahira, Y., Y.Takashima, S.Kobayashi, Y.Matsumoto, T.Takeuchi, M.Ohyanagi-Hara, A.Yoshida, A.Ohwada, H.Akiba, H.Yagita, K.Okumura, H.Ogawa.
    • Journal Title

      Infect Immun 73

      Pages: 7356-7365

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16616008
  • [Journal Article] Blockade of B7-H1 on macrophages suppresses CD4+ T cell proliferation by augmenting IFN-gamma-induced nitric oxide production.2005

    • Author(s)
      Yamazaki, T., H.Akiba, A.Koyanagi, M.Azuma, H.Yagita, K.Okumura.
    • Journal Title

      J Immunol 175

      Pages: 1586-1592

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16616008
  • [Journal Article] リンパ球の活性化・機能調節とリンパ球機能分子2005

    • Author(s)
      秋葉 久弥
    • Journal Title

      日本臨牀 増刊号 臨床免疫学(上) 63

      Pages: 34-39

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16616008
  • [Journal Article] The role of ICOS in the CXCR5^+ follicular B helper T cell maintenance in vivo.2005

    • Author(s)
      Hisaya Akiba
    • Journal Title

      The Journal of Immunology 175

      Pages: 2340-2348

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16616008
  • [Journal Article] Critical contribution of CD80 and CD86 to induction of anterior chamber-associated immune deviation.2005

    • Author(s)
      Tsukahara, R., M.Takeuchi, H.Akiba, T.Kezuka, K.Takeda, Y.Usui, M.Usui, H.Yagita, K.Okumura
    • Journal Title

      Int Immunol 17

      Pages: 523-530

    • NAID

      10019359132

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16616008
  • [Journal Article] Regulation of murine chronic colitis by CD4+CD25- programmed death-1+ T cells2005

    • Author(s)
      Totsuka, T., T.Kanai, S.Makita, R.Fujii, Y.Nemoto, S.Oshima, R.Okamoto, A.Koyanagi, H.Akiba, K.Okumura, H.Yagita, M.Watanabe.
    • Journal Title

      Eur J Immunol 35

      Pages: 1773-1785

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16616008
  • [Journal Article] ICOS costimulates invariant NKT cell activation.2005

    • Author(s)
      Kaneda, H., K.Takeda, T.Ota, Y.Kaduka, H.Akiba, Y.Ikarashi, H.Wakasugi, M.Kroneneberg, K.Kinoshita, H.Yagita, K.Okumura.
    • Journal Title

      Biochem Biophys Res Commun 327

      Pages: 201-207

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16616008
  • [Journal Article] Blockade of 4-1BB (CD137)/4-1BB ligand interactions increases allograft survival.2004

    • Author(s)
      Cho, H.R., B.Kwon, H.Yagita, S.La, E.A.Lee, J.E.Kim, H.Akiba, J.Kim, J.H.Suh, D.S.Vinay, S.A.Ju, B.S.Kim, R.S.Mittler, K.Okumura, B.S.Kwon.
    • Journal Title

      Transpl Int 17

      Pages: 351-361

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16616008
  • [Journal Article] B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism.2004

    • Author(s)
      Matsumoto, K., H.Inoue, T.Nakano, M.Tsuda, Y.Yoshiura, S.Fukuyama, F.Tsushima, T.Hoshino, H.Aizawa, H.Akiba, D.Pardoll, N.Hara, H.Yagita, M.Azuma, Y.Nakanishi.
    • Journal Title

      J Immunol 172

      Pages: 2530-2541

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16616008
  • [Journal Article] Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy.2004

    • Author(s)
      Takeda, K., N.Yamaguchi, H.Akiba, Y.Kojima, Y.Hayakawa, J.E.Tanner, T.J.Sayers, N.Seki, K.Okumura, H.Yagita, M.J.Smyth.
    • Journal Title

      J Exp Med 199

      Pages: 437-448

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16616008
  • [Journal Article] 2006. The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis

    • Author(s)
      Usui, Y., H., Akiba, M., Takeuchi, T., Kezuka, A., Takeuchi, T., Hattori, Y., Okunuki, T., Yamazaki, H., Yagita, M., Usui, K., Okumura
    • Journal Title

      European journal of immunology 36

      Pages: 3071-3081

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Presentation] 気管支喘息患者における血中可溶性TIM-4濃度2020

    • Author(s)
      田辺悠記、原田紀宏、原田園子、笹野仁史、三道ユウキ、 松野圭、竹重智仁、牧野文彦、伊藤潤、熱田了、三宅幸子、高橋和久、秋葉久弥
    • Organizer
      第60回日本呼吸器学会学術講演会
    • Data Source
      KAKENHI-PROJECT-20H03472
  • [Presentation] 喘息モデルマウスにおけるキチン誘導性ステロイド抵抗性気道炎症の解析2020

    • Author(s)
      竹重智仁、原田紀宏、石森絢子、松野圭、原田園子、笹野仁史、田辺悠記、三道ユウキ、桂蓉子、牧野文彦、伊藤潤、秋葉久弥、高橋和久
    • Organizer
      第60回日本呼吸器学会学術講演会
    • Data Source
      KAKENHI-PROJECT-20H03472
  • [Presentation] 気管支喘息のバイオマーカーとしての血清テネイシンC値の可能性2018

    • Author(s)
      浅地美奈、原田紀宏、原田園子、石森絢子、桂蓉子、糸魚川幸成、松野圭、牧野文彦、伊藤潤、小野純也、飛野和則、秋葉久弥、熱田了、出原賢治、高橋和久
    • Organizer
      第67回日本アレルギー学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09924
  • [Presentation] Circulating levels of soluble TIM-4 in the patients with asthma2018

    • Author(s)
      Yuki Tanabe, Hisaya Akiba, Norihiro Harada, Kei Matsuno, Jun Ito, Kazuhisa Takahashi, and Sachiko Miyake
    • Organizer
      第47回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09924
  • [Presentation] Circulating levels of tenascin-C as type 2 biomarkers in the patients with asthma2018

    • Author(s)
      M. Asaji, N. Harada, S. Harada, A. Ishimori, Y. Katsura, Y. Itoigawa, K. Matsuno, F. Makino, J. Ito, J. Ono, K. Tobino, H. Akiba, R. Atsuta, K. Izuhara, K. Takahashi
    • Organizer
      第58回日本呼吸器学会会学術講演会
    • Data Source
      KAKENHI-PROJECT-16K09924
  • [Presentation] 免疫チェックポイントTIMの慢性炎症における働き2018

    • Author(s)
      秋葉久弥
    • Organizer
      第36回呼吸器・免疫シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K09924
  • [Presentation] Chitin Induced Airway Inflammation and Production of Prostaglandin E22018

    • Author(s)
      T. Takeshige, N. Harada, K. Matsuno, A. Ishimori, Y. Tanabe, H. Sasano, A. Nakamura, S. Harada, Y. Katsura, F. Makino, J. Ito, R. Atsuta, H. Akiba, K. Takahashi
    • Organizer
      第58回日本呼吸器学会会学術講演会
    • Data Source
      KAKENHI-PROJECT-16K09924
  • [Presentation] Expression of TIM-4 in normal cornea and corneal grafts2018

    • Author(s)
      A. Takeda, H. Taniguchi, T. Kunishige, H. Akiba, H. Yagita, J. Hori
    • Organizer
      The Annual Meeting of the Association for Research in Vision and Ophthalmology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09924
  • [Presentation] ヒト気道上皮細胞におけるキチンによるPGE2産生誘導2018

    • Author(s)
      竹重智仁、原田紀宏、石森絢子、松野圭、原田園子、三道ユウキ、上田翔子、安部寿美子、中村愛、笹野仁史、田辺悠記、桂蓉子、牧野文彦、伊藤潤、秋葉久弥、熱田了、高橋和久
    • Organizer
      第67回日本アレルギー学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09924
  • [Presentation] 上皮間葉転換が誘導された気道上皮細胞におけるケモカイン産生2017

    • Author(s)
      松野圭, 原田紀宏, 石森絢子, 竹重智仁, 桂蓉子, 三道ユウキ, 中村愛, 笹野仁史, 田辺悠記, 牧野文彦, 伊藤潤, 熱田了, 秋葉久弥, 高橋和久
    • Organizer
      第66回日本アレルギー学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09924
  • [Presentation] Serum tenascin-C levels in patients with asthma2017

    • Author(s)
      Norihiro Harada, Mina Asaji, Sonoko Harada, Ayako Ishimori, Yoko Katsura, Yukinari Itoigawa, Kei Matsuno, Fumihiko Makino, Jun Ito, Junya Ono, Kazunori Tobino, Hisaya Akiba, Ryo Atsuta1, Kenji Izuhara, and Kazuhisa Takahashi
    • Organizer
      The 22nd Congress of the Asian Pacific Society of Respirology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09924
  • [Presentation] The effect of mepolizumab treatment in patients with severe asthma2017

    • Author(s)
      Yuuki Sandhu, Norihiro Harada, Kei Matsuno, Sonoko Harada, Tomohito Takeshige, Ayako Ishimori, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
    • Organizer
      The 22nd Congress of the Asian Pacific Society of Respirology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09924
  • [Presentation] Role of B7-H3/TLT-2 pathway in immune privilege of corneal allografts2017

    • Author(s)
      Taniguchi, H Hase, H Akiba, H Yagita, M Azuma
    • Organizer
      ARVO 2017 (The Association for Research in Vision and Ophthalmology)
    • Place of Presentation
      Baltimore, USA
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462700
  • [Presentation] Chitin induced airway inflammation and production of prostaglandin E22017

    • Author(s)
      Tomohito Takeshige, Norihiro Harada, Kei Matsuno, Ayako Ishimori, Yuki Tanabe, Hitoshi Sasano, Ai Nakamura, Sonoko Harada, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
    • Organizer
      The 22nd Congress of the Asian Pacific Society of Respirology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09924
  • [Presentation] Anti-TIM-3 treatment exacerbates pulmonary inflammation and fibrosis in mice2017

    • Author(s)
      Takuma ISSHIKI, Hisaya AKIBA, Masafumi NAKAYAMA, Norihiro HARADA, Ko OKUMURA, Sachiko MIYAKE
    • Organizer
      第46回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09924
  • [Presentation] 抗TIM-3抗体は死細胞貪食を阻害してブレオマイシン肺臓炎を悪化させる2017

    • Author(s)
      一色琢磨, 秋葉久弥,中山勝文, 原田紀宏, 奥村康, 三宅幸子, 本間栄
    • Organizer
      第21回東京呼吸病態研究会
    • Data Source
      KAKENHI-PROJECT-16K09924
  • [Presentation] TWEAK enhances epithelial mesenchymal transition and chemokine production in human bronchial epithelial cells2017

    • Author(s)
      Kei Matsuno, Norihiro Harada, Itoigawa Yukinari, Tomohito Takeshige, Sonoko Harada, Ayako Ishimori, Yuki Tanabe, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
    • Organizer
      第46回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09924
  • [Presentation] TWEAK and TGF-β induced chemokine production in human bronchial epithelial cells during epithelial mesenchymal transition2017

    • Author(s)
      Kei Matsuno, Norihiro Harada, Tomohito Takeshige, Ayako Ishimori, Yuki Tanabe, Hitoshi Sasano, Ai Nakamura, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
    • Organizer
      The 22nd Congress of the Asian Pacific Society of Respirology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09924
  • [Presentation] TIM-3 regulates pulmonary fibrosis through apoptotic cell clearance2016

    • Author(s)
      ISSHIKI Takuma, AKIBA Hisaya, NAKAYAMA Masafumi, HARADA Norihiro, OKUMURA Ko, MIYAKE Sachiko
    • Organizer
      第45回日本免疫学会
    • Place of Presentation
      沖縄コンベンションセンター、ラグナガーデンホテル
    • Year and Date
      2016-12-05
    • Data Source
      KAKENHI-PROJECT-26293087
  • [Presentation] Expression of ICOS and Foxp3 on T cells infiltrating in corneal allografts2016

    • Author(s)
      H Taniguchi, T Kunishige, H Akiba, H Yagita, R Abe, J Hori
    • Organizer
      ARVO 2016 (The Association for Research in Vision and Ophthalmology)
    • Place of Presentation
      Seattle, WA, USA
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462700
  • [Presentation] TIM-3 regulates pulmonary fibrosis through apoptotic cell clearance2016

    • Author(s)
      ISSHIKI Takuma, AKIBA Hisaya, NAKAYAMA Masafumi, HARADA Norihiro, OKUMURA Ko, MIYAKE Sachiko
    • Organizer
      第45回日本免疫学会
    • Place of Presentation
      沖縄コンベンションセンター、ラグナガーデンホテル
    • Year and Date
      2016-12-05
    • Data Source
      KAKENHI-PROJECT-16K09924
  • [Presentation] Expression of ICOS and Foxp3 on T cells infiltrating in corneal allografts2016

    • Author(s)
      H Taniguchi, T Kunishige, H Akiba, H Yagita, R Abe, J Hori
    • Organizer
      ARVO
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2016-05-01
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462700
  • [Presentation] OX40L BLOCKADE PROTECTS AGAINST SKIN AND LUNG INFLAMMATION-DRIVEN FIBROSIS2016

    • Author(s)
      M. Elhai, J. Avouac, A.-M. Hoffmann-Vold, J. Sadoine, T. Guilbert, H. Akiba, V. Heissmeyer, A. Subramaniam, R. Resnick, G. Chiocchia, Y. Allanore
    • Organizer
      欧州リウマチ学会 EULAR 2016
    • Place of Presentation
      London, UK
    • Year and Date
      2016-06-08
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09924
  • [Presentation] ICOS promotes group 2 innate lymphoid cell activation in lungs.2015

    • Author(s)
      KAMACHI Fumitaka, ISSHIKI Takuma, HARADA Norihiro, AKIBA Hisaya, MIYAKE Sachiko
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-25461503
  • [Presentation] Breast milk conditions intestinal immune system and gut barrier of the infant.2015

    • Author(s)
      SAKAGUCHI Keita, KAWASAKI Akemi, KAMACHI Fumitaka, CHIBA Asako, AKIBA Hisaya, SHIMIZU Toshiaki, MIYAKE Sachiko
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-25461503
  • [Presentation] Soluble form of TIM-4 regulates mast cell activation by binding to LMIR5 and TIM-3.2013

    • Author(s)
      KAMACHI Fumitaka, HARADA Norihiro, NISHIYAMA Chiharu, IZAWA Kumi, KITAURA Jiro, OKUMURA Ko, MIYAKE Sachiko, AKIBA Hisaya
    • Organizer
      第42回 日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ、千葉市
    • Data Source
      KAKENHI-PROJECT-23390260
  • [Presentation] Soluble form of TIM-4 regulates mast cell activation by binding to LMIR5 and TIM-32013

    • Author(s)
      KAMACHI Fumitaka, HARADA Norihiro, NISHIYAMA Chiharu, IZAWA Kumi, KITAURA Jiro, OKUMURA Ko, MIYAKE Sachiko, AKIBA Hisaya
    • Organizer
      第42回 日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ、千葉市
    • Data Source
      KAKENHI-PROJECT-25461503
  • [Presentation] Anti-TIM-4 mAb ameliorates allergic lung inflammation by inhibiting TIM-4-mediated mast cell stimulation2013

    • Author(s)
      F. Kamachi, M. Hara, N. Harada, Y. Katsura, Y. Kojima, K. Izawa, C. Nishiyama, K. Okumura, H. Akiba
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Data Source
      KAKENHI-PROJECT-25461503
  • [Presentation] Anti-TIM-4 mAb ameliorates allergic lung inflammation by inhibiting TIM-4-mediated mast cell stimulation2013

    • Author(s)
      F. Kamachi, M. Hara, N. Harada, Y. Katsura, Y. Kojima, K. Izawa, C. Nishiyama, K. Okumura, H. Akiba
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Data Source
      KAKENHI-PROJECT-23390260
  • [Presentation] マウス関節炎におけるTIM-4の病態関与:増悪と抑制2012

    • Author(s)
      秋葉 久弥
    • Organizer
      第56回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東 京・グランドプリンスホテル新高輪
    • Invited
    • Data Source
      KAKENHI-PROJECT-22591098
  • [Presentation] TIM-1 signaling in B cells regulates antibody production2007

    • Author(s)
      Akiba H.
    • Organizer
      日本免疫学会
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Year and Date
      2007-11-20
    • Data Source
      KAKENHI-PROJECT-19592040
  • [Presentation] TIM-1 signaling in B cells regulates antibody production2007

    • Author(s)
      Akiba Hisaya
    • Organizer
      第37回日本免疫学会
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Year and Date
      2007-11-20
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Presentation] TIM-1 signaling in B cells regulates antibody production2007

    • Author(s)
      Akiba Hisaya
    • Organizer
      第37回日本免疫学会
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Year and Date
      2007-11-20
    • Data Source
      KAKENHI-PROJECT-19592040
  • [Presentation] TIM-1 signaling in B cells regulates antibody production2007

    • Author(s)
      Akiba, Hisaya
    • Organizer
      The 37th Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      Grand Prince Hotel New Takanawa
    • Year and Date
      2007-11-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390292
  • [Presentation] Anti-TIM-4 mAb ameliorates allergic lung inflammation.

    • Author(s)
      F. Kamachi, N. Harada, J. Ito, K. Takahashi, K. Okumura, S. Miyake, H. Akiba
    • Organizer
      The Multifaceted Roles of Type 2 Immunity
    • Place of Presentation
      Bruges, Belgium
    • Year and Date
      2014-12-10 – 2014-12-12
    • Data Source
      KAKENHI-PROJECT-25461503
  • 1.  NAKANO Hiroyasu (70276476)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 1 results
  • 2.  NAKAYAMA Katsufumi (20453582)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 4 results
  • 3.  OKUMURA Ko (50009700)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 26 results
  • 4.  KAZUYOSHI Takeda (80272821)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 5.  HARADA norihiro (10465065)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 25 results
  • 6.  ABE yoshiyuki (10647027)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 6 results
  • 7.  KOJIMA Yuko (60231312)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 8.  YAGITA Hideo (30182306)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 16 results
  • 9.  USUI Yoshihiko (50408142)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 10.  USHIO Hiroko (30317391)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  Hori Junko (60251279)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 12.  Azuma Miyuki (90255654)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 13.  Abe Ryo (20159453)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 14.  江端 智彦 (30343487)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  谷口 ヒロ子 (00535445)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 16.  國重 智之 (60516045)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 17.  多田 昇弘 (50338315)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  KAMACHI Fumitaka
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 19.  ISSHIKI Takuma
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 20.  UENO Satoki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  TAKESHIGE tomohito
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  HARADA sonoko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 6 results
  • 23.  MATSUNO kei
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 24.  KOMOHARA Yoshihiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  TAKAMURA Shiki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  TAKAHASHI Kayo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  三宅 幸子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 28.  服部 貴明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  上野 宏樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  成松 明知
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  和田 淳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  中司 敦子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  大場 雄介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 34.  地主 将久
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 35.  吉山 裕規
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 36.  木下 一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 37.  伊藤 潤
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 38.  橋口 昌章
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 39.  石井 直人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 40.  永井 重徳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 41.  竹屋 元裕
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 42.  出原 賢治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 43.  辻 佐智代
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 44.  宮澤 正顕
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 45.  今西 健一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 46.  高橋 尚人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 47.  樗木 俊聡
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 48.  澤田 賢一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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