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NISHI Katsuhide
西 勝英
Connect your ORCID iD
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Researcher Number
00040220
Affiliation (based on the past Project Information)
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1994 – 2002: 熊本大学, 医学部, 教授
2001: 熊本大学, 医学部・二薬理, 教授
1998: 教授
1997: Kumamoto University, School of Medicine, Professor, 医学部・第二薬理講座, 教授
1988 – 1992: 熊本大学, 医学部, 教授
1986: Kumamoto University Medical School, 医学部, 教授
Review Section/Research Field
Principal Investigator
General pharmacology
/
応用薬理学・医療系薬学
Except Principal Investigator
応用薬理学・医療系薬学
/
General pharmacology
/
Immunology
/
General physiology
Keywords
Principal Investigator
プロトオンコジーンc-kit / smooth muscle / mouse / 平滑筋 / アセチルコリン / c-kit / マウス / pacemaker / Hirschsprung's病患者結腸 / 自発性Ca^<2+>-activated K^+電流
…
More
/ interstitial cell (IC) / 酸化アルブミン / Ca^<2+> storage / hunger contraction of the ileum / 蛋白チロシンキナーゼ / 自動運動能 / 細胞内Ca^<2+>濃度測定 / αー1酸性糖タンパク / TEA感受性Ca^<2+>活性化K^+電流 / 細胞内K活性 / 抗c-kit発現チロシンキナーゼ抗体 / 細隙通過促進作用 / ryanodine感受性Ca^<2+>貯蔵部位 / Ion-selective microelectrode / Ca^<2+>放出機構 / カハ-ル細胞 / isolated gastric smooth muscle cell / 興奮性膜イオンチャネル / α_1酸性糖蛋白 / モノクローナル抗体(ACK2) / 白血球走化性抑制作用 / 腸管平滑節細胞 / 人口酸素運搬体 / 細胞内カルシウム / S-nitrosylation / 自動運動のペースメーカー機構 / 移植心筋 / intracellular Ca^<2+> / apamins-sensitive channel / c-kit陽性細胞 / 細胞内Ca^<2+>貯蔵部位 / Ca^<2+>-activated K^+電流 / 胃平滑筋単離細胞 / プロトオンコジンc-kit / 腸管自動運動ペースメーカー機構 / ionic channel in excitable membrane / パッチクランプ法 / 蠕動運動 / gastrointestinal tract / cardiac action potential / 腸管ペ-スメ-カ-機構 / 腸管自動能発達過程 / GI motility ileum / antibody for kit-protein (ACK2) / cultured c-kit (+) cell / シトクロムb562変異体 / intracellular Na activity / caffeine / 発達過程 / 胃平滑筋 / intestinal smooth muscle / α-1酸性糖タンパク / 内皮細胞由来過分極因子(EDHF) / pyridoxalated hemoglobin polyoxyethylene conjugate / patch-clamp technique / c-Kit / 細胞内Ca濃度 / S1)ラット / ヒト血清アルブミン / Ca^<2+> / S-ニトロソ化 / ペースメーカー細胞 / α_1-acid glycoprotein / 細胞内Ca^<2+> / リセプタ-・チロシンキナ-ゼ / 抗体マウスc-kit抗体 / アパミン感受性Kチャネル / c-kit発現 / 腸管運動の発達 / カハール細胞 / distribution of c-Kit expressing cells / gut pacemaker mechanism / 歩調取り部位(pacemaker area) / ブラジキニン / 微細循環改善作用 / マウス胎児心筋 / colon of Hierschprung's disease patient / イノシトール三燐酸受容体 / 腸管ペースメーカー活動 / 麻痺性イレウス / Ca^<2+>貯蔵部位 / Kチャネル / transplanted myocardium / Cajar's interstitial cell / 胎児心筋活動電位 / 膀胱平滑筋 / autonomic motility / 電気的徐波 / カフェイン・カルバコール応答 / 腸管平滑筋 / c-kit免疫活性陽性細胞の分布 / ACK2に対する蛍光抗体法 / 空腹時強収縮波群形成 / ピリドキシル化ポリオキシエチレンヘモグロビン重合体 / sarcoplasmic reticulum / inplannted myocardium / Naチャネル / 血漿由来HSA / Cーkitプロトオンコジ-ン / リアノジン受容体 / シトクロムb562 / 配位子結合性 / c-kit発現細胞 / カハールの間質細胞 / 分化 / マウス膀胱平滑筋 / neutralizing mouse anti-c-Kit antibody / developmental process of intestinal movement / イオン選択性電極 / 胃平滑筋細胞内筋小胞体 / cytochrome b562 / Cys残基 / ミオグロビン / ミオグロビン変異体 / 心筋活動電位 / エンドセリンB受容体を欠乏するAR(S1 / recombinant human serum albumin / 組換え型HSA / 抗マウスc-kit抗体 / イオンチャネル / Kit / 腎被膜下移植心筋 / ペースメーカー / protooncogene c-kit / 変異アルブミン / development / 血流阻害抑制作用 / プロスタグランジンF_2α / protein tyrosinekinase / 腸管ペースメーカー機構 / c-kit tyrosinekinase / 心筋ペ-スメ-カ- / ヒト慢性特発性偽腸閉塞症 / Caチャンネル,Kチャンネル / 組換え型アルブミン / 細胞内Na活性 / 炎症 / pacemaker activity / 抗c-kitモノクローナル抗体(ACK2) / ポリオキシエチレン・重合ヘモグロビン(PHP) / human serum albumin
…
More
Except Principal Investigator
c-kit / 不整脈 / パッチクランプ法 / caffeine / 抗不整脈薬 / アミロライド / ryanodine / 強心薬 / イオンチャネル / smooth muscle / 細胞内Ca^<2+>貯蔵部位 / 細胞内pH / Gタンパク / マウス / mouse / fura-2 / AMPA / Na / Kチャネル / DIDS / プロスタグランジン / GTP / 膜電位感受性色素 / MQAE / 内因性ジギタリス様物質 / エンドセリン / Ca^<2+>トランジエント / クロライド電流 / メモリーT細胞 / 受容体平滑筋 / ブメタニド / CCP / イオン感受性電極 / ryanodine感受性Ca^<2+>ストア / 不整脈モデル / electrophysiology / Ca^<2+> storage / DIDS ; / イヌ / ATP感受性カリウム電流 / クロライドフリー / DIDS; / 筋小胞体 / anti c-KIT monoclonal antibody (ACK2) / contraction / 心臓突然死 / bFGF / サザンカサポニン / ion channel / Intracellular chloride concentration / Cl^-トランスポート阻害薬 / Clチャネル / 興奮伝播マッピング / スチルベン酸誘導体; / neurite elongation / 心室性不整脈 / Na^+チャンネル / Na-H exchange / 脊髄後根神経節細胞 / 心筋梗塞 / 細胞内Cl^-ホメオスタシス / 副刺激分子 / arhvthmia / ミトコンドリアアンカップラ / 等尺性張力 / Na・Ca交換 / Na・H交換 / intracellular Ca^<2+> / 平滑筋 / 虚血性心疾患 / ryanodine感受性Ca^<2+>放出 / Ischemia / reperfusion / モルモット / Action potentials. / リゾフォスファチジ-ルコリン / シナプスの形成 / 心筋細胞 / 細胞内Cl^-濃度; / kainate型シナプス / patch-clamp technique / 平滑筋細胞 / Intracellular pH ; / hippocampus / ミトコンドリアの代謝抑制 / ジャーカットT細胞 / 心筋細胞虚血; / MHC / sudden death / Cl^--oscillation / クロライドオシレション / 短鎖アシルカルニチン / kainate型シナプス活動 / 抗原提示細胞 / トリプシン / ペプチド抗原 / 交感神経緊張 / マウス心筋虚血再灌流 / α_1酸性糖蛋白質 / cardioprotective drugs / 心筋細胞活動電位. / Intracellular chloride concentrations ; / 細胞内pH; / 細胞内Ca^<2+>動態 / Cardiac ischemia ; / α_1-acid glycoprotein / SITS ; / Ca交換 / antiarrhythmic drug / Caチャネル / Patch-clamp technique / receptor / ATP感受性Kチャネル / Cl^--HCO_3-exchanger / Ca^<2+>貯蔵部位 / 神経突起の伸展 / 電気生理学 / 心筋虚血再灌流 / 受容体 / 細胞内Ca^<2+> / Ionic selective microelectrodes ; / 細胞外ATP・ / 細胞外ATP / ラット心筋梗塞モデル / Mitochondrial uncouplers / プリン作動性チャネル / 心臓保護薬 / 抗c-KITモノクローナル抗体 / イオン選択性微小電極 / Extracellular ATP / DNP / pacemaker / クラスIII抗不整脈薬 / 海馬ニューロン / SITS / K_<ATP> channel / Stilbene derivatives ; / C-KITチロシンキナーゼレセプター / クロライド感受性蛍光染料 / AVブロック / 突然死 / 心収縮力 / 細胞内クロライド濃度 / 心室細動 / シナプス応答 / ランダウン / kainate receptor-mediated excitatory postsynaptic currents / シナプス形成 / synaptic formation / 心筋細胞虚血 / 抗 c-KIT モノクローナル抗体 / 心筋虚血 / 電圧依存性なNa^+チャンネル / CD4^+T細胞 / イオン選択性微小電極; / 細胞内Cl^-濃度 / K_<ATP>チャネル / Cl^-オシレーション / H交換 / ペースメーカー / 心筋虚血再灌流損傷 / T細胞 / トランスポーター / Ca exchange / 中枢神経機能 / cortex / Cl^--HCO_3^-交換系 / スチルベン酸誘導体 / 収縮 / 胃平滑筋 / Cl^--channels / arrhythmia / Cl^-チャネル / SITS; / 心不全 / H exchanger / クロライドチャネル遮断薬 / 細胞内クロライド / 心筋細胞活動電位 / 局所心筋層血流量 / 大脳皮質ニューロン
Less
Research Projects
(
21
results)
Co-Researchers
(
38
People)
Project Start Year (Newest)
Project Start Year (Oldest)
Roles of Kit signalling in smooth muscle tissues
Principal Investigator
Principal Investigator
NISHI Katsuhide
Project Period (FY)
2001 – 2002
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
General pharmacology
Research Institution
KUMAMOTO UNIVERSITY
Roles of c-kit in development and pathophysiology of smooth muscle
Principal Investigator
TOKUTOMI Yoshiko
Project Period (FY)
2001 – 2003
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
General pharmacology
Research Institution
Kumamoto University
T細胞の活性化におけるNa^+イオンおよびNa^+イオン・チャンネルの役割
Principal Investigator
西村 泰治
Project Period (FY)
1999
Research Category
Grant-in-Aid for Exploratory Research
Research Field
Immunology
Research Institution
Kumamoto University
Pharmacological prevention of sudden cardiac death
Principal Investigator
HASHIMOTO Keitaro
Project Period (FY)
1999 – 2001
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
応用薬理学・医療系薬学
Research Institution
Yamanashi Medical University
Roles of c-kit in functional development of Ca^<2+> release mechanism in smooth muscle cells
Principal Investigator
TOKUTOMI Yoshiko
Project Period (FY)
1999 – 2000
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
General pharmacology
Research Institution
KUMAMOTO UNIVERSITY
Analysis of mechanisms for intracellular Cl^- homeostasis in cardiac cells and its physiological significances.
Principal Investigator
HOUICHI Yorinaka
Project Period (FY)
1999 – 2002
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
General pharmacology
Research Institution
Kumamoto University
Application of plasma proteins as blood substitutes
Principal Investigator
Principal Investigator
NISHI Katsuhide
Project Period (FY)
1999 – 2001
Research Category
Grant-in-Aid for University and Society Collaboration
Research Field
General pharmacology
Research Institution
KUMAMOTO UNIVERSITY
心臓突然死の機序および薬物による予防法
Principal Investigator
HASHIMOTO Keitaro
Project Period (FY)
1998
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
応用薬理学・医療系薬学
Research Institution
山梨医科大学
Molecular mechanism of development of mammalian smooth mscle
Principal Investigator
Principal Investigator
NISHI Katsuhide
Project Period (FY)
1998 – 2000
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
General pharmacology
Research Institution
KUMAMOTO UNIVERSITY
Roles of c-KIT on the development in synaptic function and CaィイD12+ィエD1 signaling
Principal Investigator
TOKUTOMI Nofumi
Project Period (FY)
1998 – 1999
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
General pharmacology
Research Institution
Kumamoto University
Molecular basis for occurence of the spontaneous activity of smooth muscle-consisting organs, and its functinal disorder.
Principal Investigator
Principal Investigator
NISHI Katsuhide
Project Period (FY)
1996 – 1997
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
応用薬理学・医療系薬学
Research Institution
Kumamoto University
The relationship between changes in intracellular ion concentrations and the antiarrhythmic effects of stilbene derivatives
Principal Investigator
LAI Zhong-Fang
Project Period (FY)
1996 – 1997
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
応用薬理学・医療系薬学
Research Institution
Kumamoto University
中枢シナプス可塑性におけるc-kitチロシンキナーゼレセプターの役割
Principal Investigator
TOKUTOMI Naohumi
Project Period (FY)
1995
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
General physiology
Research Institution
Kumamoto University
Electropharmacologycal therapy for lethal arrhythmias
Principal Investigator
HASHIMOTO Keitaro
Project Period (FY)
1995 – 1996
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
応用薬理学・医療系薬学
Research Institution
Yamanashi Medical University
A Role of c-kit tyrosinekinase of physiological development of the gastrointestinal pacemaker activity
Principal Investigator
Principal Investigator
NISHI Katsuhide
Project Period (FY)
1994 – 1996
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
General pharmacology
Research Institution
KUMAMOTO UNIVERSITY
心筋の異常興奮と伝導のメカニズム
Principal Investigator
有田 真
Project Period (FY)
1991
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
大分医科大学
心筋の異常興奮と伝導のメカニズム
Principal Investigator
有田 真
Project Period (FY)
1990
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
大分医科大学
Factors influencing differentiation and development of ionic channels in cardiac muscle
Principal Investigator
Principal Investigator
NISHI Katsuhide
Project Period (FY)
1990 – 1992
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
General pharmacology
Research Institution
KUMAMOTO UNIVERSITY
心筋細胞機能障害と心作動物質
Principal Investigator
杉本 恒明
Project Period (FY)
1989
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
心筋細胞機能障害と心作動物質
Principal Investigator
杉本 恒明
Project Period (FY)
1988
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
Analysis of mechanisms of controlling <Ca^(2+)> -channels in myocardium transplanted into the renal capsular space of the rat
Principal Investigator
Principal Investigator
NISHI Katsuhide
Project Period (FY)
1984 – 1986
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
General pharmacology
Research Institution
Kumamoto University
# of Projects (Dsc)
# of Projects (Asc)
1.
TOKUTOMI Naohumi
(30227582)
# of Collaborated Projects:
8 results
# of Collaborated Products:
0 results
2.
TOKUTOMI Yoshiko
(90253723)
# of Collaborated Projects:
7 results
# of Collaborated Products:
0 results
3.
TAIRA Norio
(60004553)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
4.
HASHIMOTO Keitaro
(10004665)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
5.
LAI Zhong-Fang
(90244110)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
6.
杉本 恒明
(60019883)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
7.
栗原 敏
(90057026)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
8.
中村 隆雄
(30028112)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
9.
栗山 ひろし
(40037495)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
10.
有田 真
(60037364)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
11.
神野 耕太郎
(40025630)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
12.
小川 聡
(90124940)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
13.
頴原 嗣尚
(50037446)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
14.
平岡 昌和
(80014281)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
15.
ENDOH Masao
(40004668)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
16.
KANNO Morio
(00109422)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
17.
KIMURA Junko
(10186322)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
18.
千葉 茂俊
(30004659)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
19.
安孫子 保
(90041821)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
20.
西村 泰治
(10156119)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
21.
入江 厚
(30250343)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
22.
千住 覚
(50274709)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
23.
荒木 春夫
(80151158)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
24.
KODAMA Itsuo
(30124720)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
25.
飯島 俊彦
(30004724)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
26.
FUJINO Masayuki
(60090487)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
27.
ITOH Takeo
(70159888)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
28.
ITOH Katsuaki
(70136795)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
29.
ITOH Yuushi
(80037506)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
30.
TORIHASHI Shigeko
(90112961)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
31.
小林 繁
(00018342)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
32.
NAKAYA Haruaki
(60113594)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
33.
TSUJIMOTO Gozoh
(80172013)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
34.
UNO Tadayuki
(00183020)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
35.
OTAGIRI Masaki
(80120145)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
36.
MAEDA Hiroshi
(90004613)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
37.
KAWAMURA Tomomi
(00153015)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
38.
KADOWAKI Yoshihiro
(10145310)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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