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NISHI Katsuhide
西 勝英
Connect your ORCID iD
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Researcher Number
00040220
Affiliation (based on the past Project Information)
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1994 – 2002: 熊本大学, 医学部, 教授
2001: 熊本大学, 医学部・二薬理, 教授
1998: 教授
1997: Kumamoto University, School of Medicine, Professor, 医学部・第二薬理講座, 教授
1988 – 1992: 熊本大学, 医学部, 教授
1986: Kumamoto University Medical School, 医学部, 教授
Review Section/Research Field
Principal Investigator
General pharmacology
/
応用薬理学・医療系薬学
Except Principal Investigator
応用薬理学・医療系薬学
/
General pharmacology
/
General physiology
/
Immunology
Keywords
Principal Investigator
プロトオンコジーンc-kit / アセチルコリン / c-kit / マウス / 平滑筋 / smooth muscle / mouse / pacemaker / 心筋活動電位 / 興奮性膜イオンチャネル
…
More
/ 移植心筋 / 腸管ペースメーカー機構 / プロトオンコジンc-kit / 蛋白チロシンキナーゼ / 腸管平滑筋 / 腸管自動能発達過程 / 腸管平滑節細胞 / 腸管ペースメーカー活動 / カハール細胞 / 抗c-kit発現チロシンキナーゼ抗体 / 腸管運動の発達 / プロスタグランジンF_2α / イオンチャネル / マウス胎児心筋 / Cーkitプロトオンコジ-ン / リセプタ-・チロシンキナ-ゼ / 腸管ペ-スメ-カ-機構 / 心筋ペ-スメ-カ- / カハ-ル細胞 / 発達過程 / Naチャネル / Kチャネル / cardiac action potential / ionic channel in excitable membrane / inplannted myocardium / gut pacemaker mechanism / protooncogene c-kit / protein tyrosinekinase / intestinal smooth muscle / developmental process of intestinal movement / モノクローナル抗体(ACK2) / 麻痺性イレウス / ブラジキニン / ACK2に対する蛍光抗体法 / 自動運動のペースメーカー機構 / c-kit発現細胞 / 抗c-kitモノクローナル抗体(ACK2) / 胃平滑筋 / 細胞内Ca^<2+>濃度測定 / Ca^<2+>-activated K^+電流 / 膀胱平滑筋 / 自発性Ca^<2+>-activated K^+電流 / c-kit発現 / ryanodine感受性Ca^<2+>貯蔵部位 / interstitial cell (IC) / pacemaker activity / gastrointestinal tract / c-kit tyrosinekinase / antibody for kit-protein (ACK2) / GI motility ileum / cultured c-kit (+) cell / 抗体マウスc-kit抗体 / 胃平滑筋単離細胞 / 胃平滑筋細胞内筋小胞体 / c-kit免疫活性陽性細胞の分布 / カハールの間質細胞 / Hirschsprung's病患者結腸 / 空腹時強収縮波群形成 / アパミン感受性Kチャネル / 抗マウスc-kit抗体 / 蠕動運動 / 電気的徐波 / 腸管自動運動ペースメーカー機構 / ヒト慢性特発性偽腸閉塞症 / 歩調取り部位(pacemaker area) / エンドセリンB受容体を欠乏するAR(S1 / S1)ラット / 内皮細胞由来過分極因子(EDHF) / neutralizing mouse anti-c-Kit antibody / isolated gastric smooth muscle cell / sarcoplasmic reticulum / distribution of c-Kit expressing cells / Cajar's interstitial cell / colon of Hierschprung's disease patient / hunger contraction of the ileum / apamins-sensitive channel / ペースメーカー / 分化 / 細胞内Ca^<2+> / Ca^<2+>貯蔵部位 / c-kit陽性細胞 / リアノジン受容体 / イノシトール三燐酸受容体 / Ca^<2+>放出機構 / マウス膀胱平滑筋 / 細胞内Ca濃度 / カフェイン・カルバコール応答 / TEA感受性Ca^<2+>活性化K^+電流 / development / Ca^<2+> storage / intracellular Ca^<2+> / ピリドキシル化ポリオキシエチレンヘモグロビン重合体 / α_1酸性糖蛋白 / S-ニトロソ化 / ヒト血清アルブミン / 組換え型アルブミン / シトクロムb562 / 酸化アルブミン / Cys残基 / ミオグロビン / 配位子結合性 / α-1酸性糖タンパク / 細隙通過促進作用 / 微細循環改善作用 / 白血球走化性抑制作用 / 炎症 / 変異アルブミン / ミオグロビン変異体 / シトクロムb562変異体 / 人口酸素運搬体 / ポリオキシエチレン・重合ヘモグロビン(PHP) / αー1酸性糖タンパク / 血流阻害抑制作用 / 組換え型HSA / 血漿由来HSA / pyridoxalated hemoglobin polyoxyethylene conjugate / α_1-acid glycoprotein / S-nitrosylation / human serum albumin / recombinant human serum albumin / cytochrome b562 / c-Kit / 自動運動能 / ペースメーカー細胞 / 細胞内カルシウム / パッチクランプ法 / 細胞内Ca^<2+>貯蔵部位 / caffeine / Kit / autonomic motility / Ca^<2+> / patch-clamp technique / 胎児心筋活動電位 / Caチャンネル,Kチャンネル / 腎被膜下移植心筋 / 細胞内Na活性 / 細胞内K活性 / イオン選択性電極 / Ion-selective microelectrode / intracellular Na activity / transplanted myocardium
…
More
Except Principal Investigator
パッチクランプ法 / 不整脈 / c-kit / 強心薬 / 抗不整脈薬 / アミロライド / イオンチャネル / ryanodine / caffeine / プロスタグランジン / Gタンパク / GTP / Ca^<2+>トランジエント / 内因性ジギタリス様物質 / エンドセリン / クロライド電流 / 膜電位感受性色素 / Kチャネル / 細胞内pH / DIDS / AMPA / Na / 細胞内Ca^<2+>貯蔵部位 / マウス / fura-2 / smooth muscle / mouse / MQAE / ATP感受性カリウム電流 / 心筋虚血 / イオン感受性電極 / 交感神経緊張 / 興奮伝播マッピング / リゾフォスファチジ-ルコリン / 短鎖アシルカルニチン / ATP感受性Kチャネル / ランダウン / トリプシン / プリン作動性チャネル / C-KITチロシンキナーゼレセプター / 中枢神経機能 / シナプス応答 / シナプス形成 / 心不全 / 虚血性心疾患 / 受容体平滑筋 / 突然死 / Na^+チャンネル / CD4^+T細胞 / MHC / ペプチド抗原 / 抗原提示細胞 / 副刺激分子 / メモリーT細胞 / 受容体 / Na・H交換 / 電気生理学 / クラスIII抗不整脈薬 / Caチャネル / Clチャネル / 筋小胞体 / Na・Ca交換 / 心収縮力 / antiarrhythmic drug / ion channel / receptor / Na-H exchange / arrhythmia / electrophysiology / スチルベン酸誘導体; / DIDS; / SITS; / 細胞内pH; / 細胞内Cl^-濃度; / 心筋細胞虚血; / イオン選択性微小電極; / 心筋細胞活動電位. / スチルベン酸誘導体 / 細胞内クロライド / 心筋細胞虚血 / イオン選択性微小電極 / 心筋細胞活動電位 / SITS / 細胞外ATP・ / モルモット / Stilbene derivatives ; / DIDS ; / SITS ; / Intracellular pH ; / Intracellular chloride concentrations ; / Cardiac ischemia ; / Ionic selective microelectrodes ; / Action potentials. / 抗c-KITモノクローナル抗体 / 神経突起の伸展 / シナプスの形成 / 海馬ニューロン / 大脳皮質ニューロン / kainate型シナプス / 脊髄後根神経節細胞 / 抗 c-KIT モノクローナル抗体 / kainate型シナプス活動 / anti c-KIT monoclonal antibody (ACK2) / neurite elongation / synaptic formation / patch-clamp technique / hippocampus / cortex / kainate receptor-mediated excitatory postsynaptic currents / 心臓突然死 / 心臓保護薬 / H交換 / Ca交換 / K_<ATP>チャネル / AVブロック / 心室細動 / 不整脈モデル / トランスポーター / 心筋梗塞 / イヌ / 心室性不整脈 / arhvthmia / sudden death / cardioprotective drugs / H exchanger / Ca exchange / K_<ATP> channel / 胃平滑筋 / 平滑筋細胞 / 細胞内Ca^<2+>動態 / Ca^<2+>貯蔵部位 / ryanodine感受性Ca^<2+>ストア / Ca^<2+> storage / Patch-clamp technique / 細胞内Cl^-濃度 / Cl^-オシレーション / Cl^-チャネル / Cl^--HCO_3^-交換系 / 心筋虚血再灌流 / ミトコンドリアの代謝抑制 / 細胞外ATP / マウス心筋虚血再灌流 / Cl^-トランスポート阻害薬 / サザンカサポニン / bFGF / 局所心筋層血流量 / 細胞内Cl^-ホメオスタシス / ラット心筋梗塞モデル / 細胞内クロライド濃度 / 心筋細胞 / ジャーカットT細胞 / 心筋虚血再灌流損傷 / クロライドオシレション / クロライドチャネル遮断薬 / クロライドフリー / T細胞 / 電圧依存性なNa^+チャンネル / クロライド感受性蛍光染料 / ミトコンドリアアンカップラ / CCP / DNP / ブメタニド / Intracellular chloride concentration / Cl^--oscillation / Cl^--channels / Cl^--HCO_3-exchanger / Ischemia / reperfusion / Extracellular ATP / Mitochondrial uncouplers / 平滑筋 / 収縮 / 細胞内Ca^<2+> / ペースメーカー / α_1酸性糖蛋白質 / 等尺性張力 / ryanodine感受性Ca^<2+>放出 / contraction / intracellular Ca^<2+> / pacemaker / α_1-acid glycoprotein
Less
Research Projects
(
21
results)
Co-Researchers
(
38
People)
Project Start Year (Newest)
Project Start Year (Oldest)
Roles of Kit signalling in smooth muscle tissues
Principal Investigator
Principal Investigator
NISHI Katsuhide
Project Period (FY)
2001 – 2002
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
General pharmacology
Research Institution
KUMAMOTO UNIVERSITY
Roles of c-kit in development and pathophysiology of smooth muscle
Principal Investigator
TOKUTOMI Yoshiko
Project Period (FY)
2001 – 2003
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
General pharmacology
Research Institution
Kumamoto University
T細胞の活性化におけるNa^+イオンおよびNa^+イオン・チャンネルの役割
Principal Investigator
西村 泰治
Project Period (FY)
1999
Research Category
Grant-in-Aid for Exploratory Research
Research Field
Immunology
Research Institution
Kumamoto University
Pharmacological prevention of sudden cardiac death
Principal Investigator
HASHIMOTO Keitaro
Project Period (FY)
1999 – 2001
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
応用薬理学・医療系薬学
Research Institution
Yamanashi Medical University
Roles of c-kit in functional development of Ca^<2+> release mechanism in smooth muscle cells
Principal Investigator
TOKUTOMI Yoshiko
Project Period (FY)
1999 – 2000
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
General pharmacology
Research Institution
KUMAMOTO UNIVERSITY
Analysis of mechanisms for intracellular Cl^- homeostasis in cardiac cells and its physiological significances.
Principal Investigator
HOUICHI Yorinaka
Project Period (FY)
1999 – 2002
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
General pharmacology
Research Institution
Kumamoto University
Application of plasma proteins as blood substitutes
Principal Investigator
Principal Investigator
NISHI Katsuhide
Project Period (FY)
1999 – 2001
Research Category
Grant-in-Aid for University and Society Collaboration
Research Field
General pharmacology
Research Institution
KUMAMOTO UNIVERSITY
心臓突然死の機序および薬物による予防法
Principal Investigator
HASHIMOTO Keitaro
Project Period (FY)
1998
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
応用薬理学・医療系薬学
Research Institution
山梨医科大学
Molecular mechanism of development of mammalian smooth mscle
Principal Investigator
Principal Investigator
NISHI Katsuhide
Project Period (FY)
1998 – 2000
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
General pharmacology
Research Institution
KUMAMOTO UNIVERSITY
Roles of c-KIT on the development in synaptic function and CaィイD12+ィエD1 signaling
Principal Investigator
TOKUTOMI Nofumi
Project Period (FY)
1998 – 1999
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
General pharmacology
Research Institution
Kumamoto University
Molecular basis for occurence of the spontaneous activity of smooth muscle-consisting organs, and its functinal disorder.
Principal Investigator
Principal Investigator
NISHI Katsuhide
Project Period (FY)
1996 – 1997
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
応用薬理学・医療系薬学
Research Institution
Kumamoto University
The relationship between changes in intracellular ion concentrations and the antiarrhythmic effects of stilbene derivatives
Principal Investigator
LAI Zhong-Fang
Project Period (FY)
1996 – 1997
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
応用薬理学・医療系薬学
Research Institution
Kumamoto University
中枢シナプス可塑性におけるc-kitチロシンキナーゼレセプターの役割
Principal Investigator
TOKUTOMI Naohumi
Project Period (FY)
1995
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
General physiology
Research Institution
Kumamoto University
Electropharmacologycal therapy for lethal arrhythmias
Principal Investigator
HASHIMOTO Keitaro
Project Period (FY)
1995 – 1996
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
応用薬理学・医療系薬学
Research Institution
Yamanashi Medical University
A Role of c-kit tyrosinekinase of physiological development of the gastrointestinal pacemaker activity
Principal Investigator
Principal Investigator
NISHI Katsuhide
Project Period (FY)
1994 – 1996
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
General pharmacology
Research Institution
KUMAMOTO UNIVERSITY
心筋の異常興奮と伝導のメカニズム
Principal Investigator
有田 真
Project Period (FY)
1991
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
大分医科大学
心筋の異常興奮と伝導のメカニズム
Principal Investigator
有田 真
Project Period (FY)
1990
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
大分医科大学
Factors influencing differentiation and development of ionic channels in cardiac muscle
Principal Investigator
Principal Investigator
NISHI Katsuhide
Project Period (FY)
1990 – 1992
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
General pharmacology
Research Institution
KUMAMOTO UNIVERSITY
心筋細胞機能障害と心作動物質
Principal Investigator
杉本 恒明
Project Period (FY)
1989
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
心筋細胞機能障害と心作動物質
Principal Investigator
杉本 恒明
Project Period (FY)
1988
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
Analysis of mechanisms of controlling <Ca^(2+)> -channels in myocardium transplanted into the renal capsular space of the rat
Principal Investigator
Principal Investigator
NISHI Katsuhide
Project Period (FY)
1984 – 1986
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
General pharmacology
Research Institution
Kumamoto University
# of Projects (Dsc)
# of Projects (Asc)
1.
TOKUTOMI Naohumi
(30227582)
# of Collaborated Projects:
8 results
# of Collaborated Products:
0 results
2.
TOKUTOMI Yoshiko
(90253723)
# of Collaborated Projects:
7 results
# of Collaborated Products:
0 results
3.
TAIRA Norio
(60004553)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
4.
HASHIMOTO Keitaro
(10004665)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
5.
LAI Zhong-Fang
(90244110)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
6.
杉本 恒明
(60019883)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
7.
栗原 敏
(90057026)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
8.
中村 隆雄
(30028112)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
9.
栗山 ひろし
(40037495)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
10.
有田 真
(60037364)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
11.
神野 耕太郎
(40025630)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
12.
小川 聡
(90124940)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
13.
頴原 嗣尚
(50037446)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
14.
平岡 昌和
(80014281)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
15.
ENDOH Masao
(40004668)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
16.
KANNO Morio
(00109422)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
17.
KIMURA Junko
(10186322)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
18.
千葉 茂俊
(30004659)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
19.
安孫子 保
(90041821)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
20.
西村 泰治
(10156119)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
21.
入江 厚
(30250343)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
22.
千住 覚
(50274709)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
23.
荒木 春夫
(80151158)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
24.
KODAMA Itsuo
(30124720)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
25.
飯島 俊彦
(30004724)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
26.
FUJINO Masayuki
(60090487)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
27.
ITOH Takeo
(70159888)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
28.
ITOH Katsuaki
(70136795)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
29.
ITOH Yuushi
(80037506)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
30.
TORIHASHI Shigeko
(90112961)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
31.
小林 繁
(00018342)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
32.
NAKAYA Haruaki
(60113594)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
33.
TSUJIMOTO Gozoh
(80172013)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
34.
UNO Tadayuki
(00183020)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
35.
OTAGIRI Masaki
(80120145)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
36.
MAEDA Hiroshi
(90004613)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
37.
KAWAMURA Tomomi
(00153015)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
38.
KADOWAKI Yoshihiro
(10145310)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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