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UCHIYAMA Takehiko  内山 竹彦

ORCIDConnect your ORCID iD *help
… Alternative Names

内山 タケヒコ  ウチヤマ タケヒコ

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Researcher Number 00050550
Affiliation (based on the past Project Information) *help 1991 – 2006: Tokyo Women's Medical College, School of Medicine, Professor, 医学部, 教授
1996: Tokyo Wemen's Medical College, Immunology, Professor, 教授
Review Section/Research Field
Principal Investigator
Bacteriology (including Mycology) / 細菌学 / Bacteriology (including Mycology)
Except Principal Investigator
Bacteriology (including Mycology) / Bacteriology (including Mycology) / Immunology / Embryonic/Neonatal medicine / Immunology / Pediatrics
Keywords
Principal Investigator
TSS / superantigen / TCR / T細胞 / スーパー抗原 / NTED / TSST-1 / T cells / Vβエレメント / 外毒素 … More / MHCクラスII分子 / SDMG / SelP / T cell / トキシックショック症候群 / SDM / HUVEC / リンフォカイン / Vβ12+T細胞 / Tcell / TCRVβ / 新生児TSS様発疹 / Vβ2^+T細胞 / MRSA / TSS-1 / YPM / Vbeta elements / lymphokines / MHC class ll molecules / 細菌感染症 / MHCクラスII / VBエレメント / SEs / bacterial exotoxins / HLA class II / IFN-r / T細胞活性化 / 外毒素反応性Tハイブリド-マ / T細胞受容体(Vβ) / MHCクラスII抗原 / ブドウ球菌外毒素 / ILー2 / toxic shock syndrome / MHC class II molecules / exotoxins / superantigens / エルシニア感染症 / TCR Vβ … More
Except Principal Investigator
スーパー抗原 / T細胞 / MRSA / superantigen / CD45 / T cells / NTED / IL-4 / IL-2 / ICOS / CD45 isoform / FOXP3 / T細胞サブセット / Lck / 胸腺外成熟 / ヒトT細胞 / infectious diseases / 新生児TSS様発疹症 / 感染症 / 臍帯血 / signal transduction / 細胞内シグナル伝達機構 / 細菌性スーパー抗原 / T cell receptor / TSST-1 / co-stimulation / 共刺激 / 感染免疫 / helper T cell differentiation / STATS / receptor for costimulatory signal / costimulatory signal / LAT / Th cell differentiation / Co-stimulation / ヘルパーT細胞分化 / STAT5 / 補助刺激シグナル受容体 / 補助刺激シグナル / human cord blood / human thymic cells / regulatory T cells / post-thymic muturation / human T cells / CD26 / 免疫寛容 / 胸腺細胞 / 制御性T細胞 / ヒト臍帯血 / ヒト胸腺細胞 / 制御性細胞 / ヒト細胞T細胞 / Super Antigen / Neonatal TSS-like Exanthematous Disease / SET / neonates / TSST- 1 / 新生児 / T-cell subsets / post-thymi c maturation / human T-cell / bacterial super-antigen / 細胞内シグナル伝達 / neonatal toxic shock syndrome-like exanthematous disease / renal cell carcinoma / toxic shock syndrome / γδT cells / Th2 / Th1 / TCR Vβ / γδT細胞 / 腎細胞癌 / 毒素性ショック症候群 / activation / maturation / differentiation / アナジー / 胸腺 / 活性化 / 成熟 / 分化 / NKT cells / differentiation and selection of T cells in the thymus / T cell activation marker / NK T細胞 / NKT細胞 / 胸腺内でのT細胞の分化、選択 / T細胞活性化マーカー / T-cell / Bacterial super-antigen / TNF-alpha / super antigen / Kawasaki disease / HLA / HHV-6 / Heat shock protein / アポトーシス / Vβレパトア / TNF-α / 川崎病 / Toxic shock syndrome / abnormal reaction / T cell activation / Exotoxin / Superantigen / 主体異常反応 / 生体異常反応 / T細胞活性化 / 細菌外毒素 / TCRVβ2 / 内毒素 / 外毒素 / 細菌感染 / 細菌毒素 / 抗菌薬 / 制御 / 標的細胞 / 病原因子 / 細菌 Less
  • Research Projects

    (21 results)
  • Research Products

    (59 results)
  • Co-Researchers

    (28 People)
  •  Study on T cell changes in response to infections and its applications

    • Principal Investigator
      IMANISHI Kenichi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Tokyo Women's Medical University
  •  Investigation of causative bacteria and host factors involved in the serious infectious diseases caused by Staphylococcus aureusPrincipal Investigator

    • Principal Investigator
      UCHIYAMA Takehiko
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Tokyo Women's Medical University
  •  The differences of immunological responses of human T cells among thymocytes, cord blood and adult peripheral blood

    • Principal Investigator
      FUJIMAKI Wakae
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Tokyo Women's Medical University
  •  Analysis of the mechanism underlying the induction of type 2 Th cell differentiation by IL-2, IL-4 and ICOS

    • Principal Investigator
      YAGI Junji
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Tokyo Women's Medical University
  •  Fundamental researches to establish a therapy of neonatal TSS-like exanthematous disease

    • Principal Investigator
      KATO Hidehito
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Tokyo Women's Medical University
  •  新しい感染症、新生児TSS様発疹症の発症機序の基礎的研究

    • Principal Investigator
      加藤 秀人
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Tokyo Women's Medical University
  •  Pathopysiology and treatment in emerging infectious disease, Neonatal TSS-like exanthematous disease, induced by exotoxin from MRSA

    • Principal Investigator
      TAKAHASHI Naoto
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Embryonic/Neonatal medicine
    • Research Institution
      Jichi Medical School
      Tokyo Women's Medical University
  •  Multiple analysis of the pathogenic mechanism of an re-emerging infectious disease, neonatal TSS-like exanthematous disease and related diseasesPrincipal Investigator

    • Principal Investigator
      UCHIYAMA Takehiko
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Tokyo Woman's Medical University
  •  Study on human T cell changes in response to infections and applications

    • Principal Investigator
      IMANISHI Ken-ichi
    • Project Period (FY)
      1999 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Tokyo Women's Medical University School of Medicine
  •  Intracellular signal transduction of activated T cells and anergic T cells

    • Principal Investigator
      FUJIMAKI Wakae
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Tokyo Woman's Medical University
  •  細菌感染症発症機構の分子生物学的手法による解析とその治療への応用

    • Principal Investigator
      小熊 惠二
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Okayama University
  •  Studies on differentiation, maturation and activation of human T cells

    • Principal Investigator
      IMANISHI Ken'ichi
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Tokyo Women's Medical University School of Medicine
  •  Role of a new T cell marker, H4, on the differentiation and selection of T cells in the thymus

    • Principal Investigator
      YAGI Junji
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Tokyo Women's Medical University
  •  細菌由来病原因子による標的細胞機能変換作用の解析

    • Principal Investigator
      本田 武司
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Osaka University
  •  Intracellular signal transduction of Tcell activated with bacterial super-antigen

    • Principal Investigator
      FUJIMAKI Wakae
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Tokyo Women's Medical University
  •  Study on Etiology and Pathogenesis of Kawasaki Disease

    • Principal Investigator
      KATO Hirohisa
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Pediatrics
    • Research Institution
      Kurume University
  •  スーパー抗原性細菌外毒素によるトレランス誘導・異常反応誘導における役割Principal Investigator

    • Principal Investigator
      内山 竹彦
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Women's Medical University
  •  Analysis of mechanisms of T cell activation by exotoxins bearing superantigenic properties and induction of abnormal changes by them.Principal Investigator

    • Principal Investigator
      UCHIYAMA Takehiko
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Tokyo Women's Medical College
  •  T cell activation by the exotoxins having superantigenic properties and abonormal reactions observed in patients with the toxin-associated illness.

    • Principal Investigator
      IMANISHI Ken'ichi
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Tokyo Women's Medical College
  •  MHCクラスII結合性と超抗原特性をもつ細菌外毒素によるT細胞活性化機序の解析Principal Investigator

    • Principal Investigator
      内山 竹彦
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      細菌学
    • Research Institution
      Tokyo Women's Medical University
  •  Analysis of T cell activation by bacterial extoxins bearing MHC class II-binding activityPrincipal Investigator

    • Principal Investigator
      UCHIYAMA Takehiko, 内山 竹彦
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      細菌学
    • Research Institution
      Tokyo Women's Medical College

All 2006 2005 2004 2003 2002 Other

All Journal Article Presentation Book

  • [Book] In the comprehensive sourcebook of bacterial protein toxins (3^<rd>edition)2006

    • Author(s)
      T.Uchiyama, et al.
    • Total Pages
      1072
    • Publisher
      Elsevier
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390130
  • [Book] The comprehensive sourcebook of bacterial protein toxins (3^<rd> edition)

    • Author(s)
      T.Uchiyama, et al.
    • Publisher
      Elsevier(In press)
    • Data Source
      KAKENHI-PROJECT-17390130
  • [Journal Article] Staphylococcal superantigens and the diseases they cause2006

    • Author(s)
      T. Uchiyama, et. al.
    • Journal Title

      The comprehensive sourcebook of bacterial protein toxins

      Pages: 830-843

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590439
  • [Journal Article] Expression, purification and crystallizaion of Streptococcus dysgalactiae-derived mitogen.2006

    • Author(s)
      Papageorgiou AC, Uchiyama T, et al.
    • Journal Title

      Acta Crystallograph Sect F Struct Biol Cryst Commun 62・Pt3

      Pages: 242-244

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] Genetic background influences Th cell differentiation by controlling the capacity for IL-2-induced IL-4 production by naive CD4+ T cells2006

    • Author(s)
      Yagi J, Uchiyama T, et al.
    • Journal Title

      Int Immunol 18・12

      Pages: 1681-1690

    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] Staphylococcal superantigens and diseases caused by them.2006

    • Author(s)
      T.Uchiyama, K Imanishi, T.Miyoshi-Akiyama, H.Kato
    • Journal Title

      In the comprehensive sourcebook of bacterial protein toxins (3^<rd> edition).(Edited by J.E. Alouf and M.R. Popoff. Elsevier.) 830

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390130
  • [Journal Article] A severe case of neonatal toxic shock syndrome-like exanthematous disease with superantigen-induced high T cell response.2006

    • Author(s)
      Miki M, Uchiyama T, et al.
    • Journal Title

      Pediatr Infect Dis 25・10

      Pages: 950-952

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] Use of DNA arrays to identify a mutation in the negative regulator, csrR, responsible for the high virulence of a naturally occurring type M3 group A streptococcus clinical isolate.2006

    • Author(s)
      Miyoshi-Akiyama T, Uchiyama T, et al.
    • Journal Title

      J Infect Dis. 193(12)

      Pages: 1677-84

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] A severe case of neonatal TSS-like exanthematous disease with superantigen-induced high T cell response.2006

    • Author(s)
      M.Miki, T.Uchiyama, et al.
    • Journal Title

      Pedjatr. Inf. Dis. J. 25

      Pages: 950-950

    • Data Source
      KAKENHI-PROJECT-17390130
  • [Journal Article] Staphylococcal superantigens and the diseases they cause2006

    • Author(s)
      T., Uchiyama
    • Journal Title

      The comprehensive sourcebook of bacterial protein toxins

      Pages: 830-43

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590439
  • [Journal Article] Lipoteichoic acid may affect the pathogenesis of bile duct damage in primary biliary cirrhosis.2006

    • Author(s)
      Haruta I, Uchiyama T, et al.
    • Journal Title

      Autoimmunity. 39(2)

      Pages: 129-35

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] Expression, purification and crystallization of Streptococcus dysgalactiae-derived mitogen.2006

    • Author(s)
      Papageorgiou AC, Uchiyama T, et al.
    • Journal Title

      Acta Crystallograph Sect F Struct Biol Cryst Commun 62(Pt3)

      Pages: 242-4

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] Expression, purification and crystallization of Streptocuccus dysgalactiae-derived mitogen.2006

    • Author(s)
      C.Papageorgiou, S.Saarinen, R.Ramirez-Bartuis, H.Kato, T.Uchiyama, T.Kirikae, T.Miyoshi-Akiyama.
    • Journal Title

      Acta Cryst. 62

      Pages: 242-242

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390130
  • [Journal Article] Safety profile and anti-tumor effects of adoptive immunotherapy using gamma-delta T cells against advanced renal cell carcinoma : a pilot study.2006

    • Author(s)
      Kobayashi H, Uchiyama T, et al.
    • Journal Title

      Cancer Immunol Immunother. (in print)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] Lipoteichoic acid may affect the pathogenesis of bile duct damage in primary biliary cirrhosis.2006

    • Author(s)
      Haruta I, Uchiyama T, et al.
    • Journal Title

      Autoimmunity 39・2

      Pages: 129-135

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] Staphylococcal superantigens and the diseases they cause2006

    • Author(s)
      T.Uchiyama et al.
    • Journal Title

      The comprehensive sourcebook of bacterial protein toxins

      Pages: 830-830

    • Data Source
      KAKENHI-PROJECT-18590439
  • [Journal Article] Use of DNA arrays to identify a mutation in the negative regulator, csrR, responsible for the high virulence of a naturally occurringtype M3 group Astreptococcus clinical isolate.2006

    • Author(s)
      Miyoshi-Akidyama, T Uchiyama T, et al.
    • Journal Title

      J Infect Dis 193・12

      Pages: 1677-1684

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] Genetic background influences Th cell differentiation by controlling the capacity for IL-2-induced I-L4 production by naive CD4+ T cells.2006

    • Author(s)
      Yagi J, Uchiyama T, et al.
    • Journal Title

      Int Immunol 18・12

      Pages: 1681-1690

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] A severe case of neonatal toxic shock syndrome-like exanthematous disease with superantigen-induced high T cell response.2006

    • Author(s)
      Miki M, Uchiyama T, et al.
    • Journal Title

      Pediatr Infect Dis J. 25(10)

      Pages: 950-2

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] A severe case of neonatal TSS-like exanthematous disease with superantigen-induced high T cell response.2006

    • Author(s)
      M.Miki, T.Uchiyama, H.Kato, H.Nishida, N.Takahashi.
    • Journal Title

      Pediatr.Inf.Dis.J. 25

      Pages: 950-950

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390130
  • [Journal Article] Genetic background influences Th cell differentiation by controlling the capacity for IL-2-induced IL-4 production by naive CD4+ T cells.2006

    • Author(s)
      Yagi J, Uchiyama T, et al.
    • Journal Title

      Int Immunol 18(12)

      Pages: 1681-90

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] CD28 is required for induction and maintenance of immuological memory in toxin-reactive CD4+ T cells in vivo.2005

    • Author(s)
      K.Fukada, M.Koyanagi, Y.Arimura, H.Ogiuchi, T.Uchiyama, J.Yagi.
    • Journal Title

      Cell.Immunol. 238

      Pages: 103-103

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390130
  • [Journal Article] Cytocidal effect of Streptococcus pyogenes on mouse neutrophils in vivo and the critical role of streptolysin S.2005

    • Author(s)
      Miyoshi-Akiyama T, Uchiyama T.et al.
    • Journal Title

      The Journal of Infectious Disease 192

      Pages: 107-116

    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] Specific inhibitory action of anisodamine against a staphylococcal superantigenic toxin, toxic shock syndrome toxin 1(TSST-1), leading to down-regulation of cytokine production and blocking of TSST-1 toxicity in mice.2005

    • Author(s)
      Nakagawa S, Uchiyama T, et al.
    • Journal Title

      Clin Diagn Lab Immunol 12・3

      Pages: 399-408

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] Specific inhibitory action of anisodamine against a staphylococcal superantigenic toxin, toxic shock syndrome toxin (TSST)-1, leading to down-regulation of cytokine production and blocking of TSST-1 toxicity in mice.2005

    • Author(s)
      S.Nakagawa, K.Kushiya, I.Taneike, K.Imanishi, Uchiyama, T.Yamamoto.
    • Journal Title

      Clin.Diag.Lab.Immunol.2005 12

      Pages: 399-399

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390130
  • [Journal Article] Cytocidal effect of Streptococcus pyogenes on mouse neutrophils in vivo and the critical role of streptolysin S.2005

    • Author(s)
      Miyoshi-Akiyama T, Uchiyama T, et al.
    • Journal Title

      J Infect Dis 192・1

      Pages: 107-116

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] Detection of heat shock proteins but not superantigen by isolated oral bacteria from patients with Behcet's disease.2005

    • Author(s)
      T.Miura, K.Ishihara, T.Kato, R.Kimizuka, H.Miyabe, T.Ando, T.Uchiyama, K.Okuda.
    • Journal Title

      Oral Microbiology and Immunology. 20

      Pages: 167-167

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390130
  • [Journal Article] Specific inhibitory action of anisodamine against a staphylococcal superantigenic toxin, toxic shock syndrome toxin 1 (TSST-1), leading to down-regulation of cytokine production and blocking of TSST-1 toxicity in mice.2005

    • Author(s)
      Nakagawa S, Uchiyama T, et al.
    • Journal Title

      Clin Diagn Lab Immunol. 12(3)

      Pages: 399-408

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] CD28 is required for induction and maintenance of immunological memory in toxin-reactive CD4+ T cells in vivo.2005

    • Author(s)
      Fukada K, Uchiyama T, et al.
    • Journal Title

      Cell Immunol. 238(2)

      Pages: 103-12

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] Cytocidal effect of Streptococcus pyogenes on mouse neutrophils in vivo and the critical role of streptolysin S.2005

    • Author(s)
      Miyoshi-Akiyama T, Uchiyama T, et al.
    • Journal Title

      J Infect Dis. 192(1)

      Pages: 107-16

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] Characterization of novel staphylococcal enterotoxin-like toxin type P.2005

    • Author(s)
      K.Omoe, K.Imanishi, D-L.Hu, H.Kato, Y.Fugane, Y.Abe, S.Hamaoka, Y.Watanabe, A.Nakane, T.Uchiyama, K.Shinagawa.
    • Journal Title

      Infect.Immune. 73

      Pages: 5540-5540

    • NAID

      120001493336

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390130
  • [Journal Article] CD28 is required for induction and maintenance of immunological memory in toxin-reactive CD4+ T cells in vivo.2005

    • Author(s)
      Fukada K, Uchiyama T, et al.
    • Journal Title

      Cell Immunol 238・2

      Pages: 103-112

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] Prospective surveillance of community-onset and healthcare-associated meticillin-resistant Staphylococcus aureus isolated from a university-affiliated hospital in Japan.2005

    • Author(s)
      C-P.Piao, T.Karasawa, K.Totsuka, T.Uchiyama, K.Kikuchi.
    • Journal Title

      Microbiol.Immunol. 49

      Pages: 959-959

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390130
  • [Journal Article] Polarization of human CD4+ T cells to T-helper type 1 and type 2 cells by superantigen stimulation.2004

    • Author(s)
      Ohnishi A, Fujimaki W, Uchiyama T, et al.
    • Journal Title

      Journal of Tokyo Women's Medical University 174・3

      Pages: 147-156

    • NAID

      110007525806

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] Immunologic immaturity, but high IL-4 productivity, of murine neonatal thymic CD4 single-positive T cells in the last stage of maturation.2004

    • Author(s)
      Koyanagi M, Uchiyama T, et al.
    • Journal Title

      Int Immunol. 16(2)

      Pages: 315-26

    • NAID

      10013083702

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] The effects of fluorescent lamp coated with a photocatalyst film on the number of floating microorganisms or smell molecules in a room installed with the lamp.2004

    • Author(s)
      Fujimaki W, Uchiyama T, et al.
    • Journal Title

      Kansenshogaku Zasshi. 78(7)

      Pages: 588-96

    • NAID

      10013762211

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] Akt is a neutral amplifier for Th cell differentation.2004

    • Author(s)
      Arimura Y, Uchiyama T, et al.
    • Journal Title

      J Biol Chem 279・12

      Pages: 11408-11416

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] Akt is a neutral amplifier for Th cell differentiation.2004

    • Author(s)
      Arimura Y, Uchiyama T, et al.
    • Journal Title

      J Biol Chem. 279(12)

      Pages: 11408-16

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] Immunologic immaturity, but high IL-4 productivity, of murine neonatal thymic CD4 single-positive T cells in the last stage of maturation.2004

    • Author(s)
      Koyanagi M, Uchiyama T, et al.
    • Journal Title

      Int Immunol 16・2

      Pages: 315-326

    • NAID

      10013083702

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] Immunologic immaturity, but high IL-4 productivity, of marine neonatal thymic CD4 single-positive T cells in the last stage f maturation2004

    • Author(s)
      Madoka Koyanagi, Takehiko Uchiyama et al.
    • Journal Title

      Internal Immunology Vol.16, No.2

      Pages: 315-326

    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] Polarization of human CD4+ T cells to T-helper type 1 and type 2 cells by superantigen stimulation.2004

    • Author(s)
      Ohnishi A, Fujimaki W, Uchiyama T, et al.
    • Journal Title

      Journal of Tokyo Women's Medical University 174

      Pages: 147-156

    • NAID

      110007525806

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] The effects of fluorescent lamp coated with a photocatalyst film on the number of floating microorganisms or smell molecules in a room installed with the lamp.2004

    • Author(s)
      Fujimaki W, Uchiyama T, et al.
    • Journal Title

      Kansenshogaku Zasshi 78・7

      Pages: 588-596

    • NAID

      10013762211

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] Immunologic immaturity, but high IL-4 productivity, of murine neonatal thymicCD4 single-positive T cells in the last stage of maturation2004

    • Author(s)
      M.Koyanagi K.Imanishi Y.Arimura H.Kato J.Yagi, T.Uchiyama
    • Journal Title

      Journal of Infection and Chemotherapy 222

      Pages: 315-326

    • NAID

      10013083702

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570246
  • [Journal Article] Maturation of adult peripheral blood CD38(+)CD4(+) T cells demonstrated by cytokine production in response to a superantigen, TSST-1.2003

    • Author(s)
      K.Imanishi, H.Kato, H.Fujii, T.Uchiyama
    • Journal Title

      Cellular Immunology 222

      Pages: 89-96

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570246
  • [Journal Article] Maturation of adult peripheral blood CD38+CD4+ T cells demonstrated by cytokine production in response to a superantigen, TSST-1.2003

    • Author(s)
      Imanishi Ken'ichi, Kato Hidehito, Fujii Hisaichi, Uchiyama Takehiko
    • Journal Title

      Cell Immunol 222(2)

      Pages: 89-96

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570246
  • [Journal Article] Superantigenic Stimulation of Bovine T Cells by Streptococcus dys-galactiae-derived mitogen (SDM).2003

    • Author(s)
      Monze Mwaka, H.Kato, T.Hayashi, Y.Abe, T.Akiyama, T.Uchiyama K.Imanishi
    • Journal Title

      東京女子医科大学雑誌 73

      Pages: 24-34

    • Data Source
      KAKENHI-PROJECT-14570246
  • [Journal Article] Superantigenic stimulation of bovine T cells by Streptococcus dysgalactiae-derived mitogen(SDM).2003

    • Author(s)
      Monze Mwaka, H.Kato, T.Hayashi, R.Abe, T.Akiyama, T.Uchiyama, K.imanishi
    • Journal Title

      J Tokyo Women's Med Univ 73(3・4)

      Pages: 88-98

    • NAID

      110007526015

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570246
  • [Journal Article] Quantitative and qualitative comparison of virulence traits, including murine lethality, among different M types of group A streptococci.2003

    • Author(s)
      Miyoshi-Akiyama Toru, Zhao Jizi, Kikuchi Ken, Kato Hidehito, Suzuki Rieko, Endo Miyoko, Uchiyama Takehiko
    • Journal Title

      J Infect Dis 187(12)

      Pages: 1876-1887

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570246
  • [Journal Article] Early and definitive diagnosis of toxic shock syndrome by detection of marked expansion of T-cell-receptor VBeta2-positive T cells.2003

    • Author(s)
      Matsuda Yoshio, Kato Hidehito, Yamada Ritsuko, Okano Hiroya, Ohta Hiroaki, Imanishi Ken'ichi, Kikuchi Ken, Totsuka Kyoichi, Uchiyama Takehiko
    • Journal Title

      Emerg Infect Dis 9(3)

      Pages: 387-389

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570246
  • [Journal Article] Streptococcus dysgalactiae-derived mitogen(SDM), a novel bacterial superantigen : characterization of its biological activity and predicted tertiary structure.2003

    • Author(s)
      Miyoshi-Akiyama Toru, Zhao Jizi, Kato Hidehito, Kikuchi Ken, Totsuka Kyoichi, Kataoka Yasushi, Katsumi Masamichi, Uchiyama Takehiko
    • Journal Title

      Mol Microbiol 47(6)

      Pages: 1589-1599

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570246
  • [Journal Article] Superantigenic Stimulation of Bovine T Cells by Streptococcus dysgalactiae- Derived Mitogen2003

    • Author(s)
      MonzeMwaka, H.Kato, T.Hayashi, Y.Abe, T.Akiyama, T.Uchiyama
    • Journal Title

      東京女子医科大学雑誌 73

      Pages: 24-34

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570246
  • [Journal Article] The percentage of superantigen-reactive T cells in peripheral blood significantly decreases before massively increasing in early acute phase patients with neonatal TSS-like exanthematous disease.2002

    • Author(s)
      H.Kato, N.Takahashi, Y.Arimura, K.Imanishi, H.Nishida, T.Uchiyama
    • Journal Title

      Journal of Infection and Chemotherapy 8

      Pages: 111-114

    • Data Source
      KAKENHI-PROJECT-14570246
  • [Journal Article] Superantigen-reactive Vb2+ T cells exhibit a significant reduction before their massive increase in some acute phase patients with TSS-like exanthematous disease.2002

    • Author(s)
      Kato Hidehito, Takahashi Naoto, Arimura Yutaka, Imanishi Ken'ichi, Nishida Hiroshi, Uchiyama Takehiko
    • Journal Title

      J Infect Chemother 8

      Pages: 111-114

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570246
  • [Journal Article] Continuous exposure of mice to superantigenic toxins induces a high-level protracted expansion and an immunological memory in the toxin-reactive CD4+ T cells2002

    • Author(s)
      Chen Luqiu, Koyanagi Madoka, Fukada Kenji, Imanishi Ken'ichi, Yagi Junji, Kato Hidehito, Miyoshi-Akiyama Toru, Miwa Keishi, Zhang Ruihua, Uchiyama Takehiko
    • Journal Title

      J Immunol 168

      Pages: 3817-3824

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570246
  • [Journal Article] A co-stimulatory molecule on activated T cells, H4/ICOS, delivers specific signals in Th cells and regulates their responses.2002

    • Author(s)
      Arimura Yutaka, Kato Hidehito, Dianzani Umberto, Okamoto Toshihiro, Kamekura Soichiro, Buonfiglio Donatella, Miyoshi-Akiyama Toru, Uchiyama Takehiko, Yagi Junji
    • Journal Title

      Int Immunol 14(6)

      Pages: 555-566

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570246
  • [Journal Article] The percentage of superantigen-reactive T cells in peripheral blood significantly decreasas before massively increasing in early acute phase patients with neonatal TSS-like exanthematous disease.2002

    • Author(s)
      H.Kato, N.Takahashi, Y.Arimura, K.Imanishi, H.Nishida, T.Uchiyama
    • Journal Title

      Journal of Infection and Chemotherapy 8

      Pages: 111-114

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14570246
  • [Journal Article] Safety profile and anti-tumor effects of adoptive immunotherapy using gamma-delta T cells against advanced renal cell carcinoma : a pilot study.

    • Author(s)
      Kobayashi H, Uchiyama T, et al.
    • Journal Title

      Cancer Immunol Immunother (in print)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590372
  • [Journal Article] Cloning, expression and characterization of the superantigen streptococcal pyrogenic exotoxin-G from Streptococcus dysgalactiae.

    • Author(s)
      J.Zhao, T.Hayashi, S.Saarinen, A.C.Papageorgiou, H.Kato, K.Imanishi, T.Kirikae 1, R.Abe, T.Uchiyama, T.Miyoshi-Akiyama.
    • Journal Title

      Infect.Immun. (In print)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390130
  • [Presentation] 新生児と成人のトキシックショック症候群の診断と発症の現状2006

    • Author(s)
      内山 竹彦, ほか
    • Organizer
      第51回日本ブドウ球菌概究会
    • Place of Presentation
      盛岡
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590439
  • 1.  IMANISHI Ken'ichi (20132920)
    # of Collaborated Projects: 13 results
    # of Collaborated Products: 14 results
  • 2.  YAGI Junji (70182300)
    # of Collaborated Projects: 13 results
    # of Collaborated Products: 1 results
  • 3.  KATO Hidehito (00241084)
    # of Collaborated Projects: 12 results
    # of Collaborated Products: 20 results
  • 4.  FUJIMAKI Wakae (90256496)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 4 results
  • 5.  IMANISHI Ken'ichi (80124527)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 6.  YAN Xiao-Jie (80195627)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 7.  AKIYAMA Toru (20246466)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  TANAKA Yoshimasa (90280700)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  KIKUCHI Ken (60214748)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 10.  本田 武司 (60029808)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  笹川 千尋 (70114494)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  中村 信一 (90019620)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  KATO Hirohisa (30080724)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  YAMANISHI Kouichi (10029811)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  OKUMURA Yasushi (50009700)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  FURUKAWA Susumu (30095830)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  YANAGISAWA Nasayoshi (90049031)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  TAKAHASHI Naoto (50197159)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  NISHIDA Hiroshi (80104553)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  HONMA Youko (10238826)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  ARIMURA Yutaka (10281677)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  MATSUDA Yoshio (10339020)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  櫻井 純 (80029800)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  篠田 純男 (50029782)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  小熊 惠二 (00002262)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  光山 正雄 (10117260)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  内山 竹彦 (30072333)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  荒明 美奈子 (20075427)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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