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NISHIYAMA Mariko  西山 眞理子

ORCIDConnect your ORCID iD *help
Researcher Number 00092081
Other IDs
Affiliation (based on the past Project Information) *help 2011 – 2014: 千葉大学, 医学(系)研究科(研究院), 助教
2013: 千葉大学, 大学院医学研究院, 助教
2008 – 2010: 千葉大学, 大学院・医学研究院, 助教
2006: Chiba University, Graduate School of Medicine, Research Associate, 大学院医学研究院, 助手
2005 – 2006: 千葉大学, 大学院・医学研究院, 助手 … More
2002 – 2003: 千葉大学, 大学院・医学研究院, 助手
1998 – 2000: Chiba University Graduate School of Medicine, Department of Biochemistry and Mol, 大学院・医学研究科, 助手
1997 – 1998: 千葉大学, 医学部, 助手
1995: 千葉大学, 医科部, 助手
1994 – 1995: 千葉大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
General pharmacology / 血管生物学
Except Principal Investigator
General pharmacology / General pharmacology / Functional biochemistry / 体育学 / Nerve anatomy/Neuropathology
Keywords
Principal Investigator
アンジオテンシンII / ウロテンシンII / RGSタンパク質 / 薬理学 / エンドセリン受容体 / エンドセリン / 収縮 / 平滑筋 / 血管
Except Principal Investigator
GPCR … More / 脱感作 / エンドセリン受容体 / エンドセリン / RGS / オーファン受容体 / ゲノム構造 / 生理活性ペプチド / JNK / PPAR-α / G蛋白質共役受容体キナーゼ / Endothelin / アンジオテンシン受容体 / アンジオテンシン / バイオインフォーマティクス / Gタンパク質共役受容体 / bioinformatics / genome structure / bioactive peptide / orphan GPCR / MAP kinases / aortic banding model / rat cardiomyocytes / Endothelin(ET)-1 / Fenofibrate / cardiac hypertrophy / MAPキナーゼ / 冠動脈結紮モデルラット / ラット心筋細胞 / エンドセリン(ET)-1 / fenofibrate / 心肥大 / endothelin / angiotensin / G protein / G蛋白質αサブユニット / G蛋白質 / REVERSE TORERANCE / DESENSITIZATION (TORERANCE) / INTRACELLULAR CA2+TRANSIENT / ANGIOTENSIN RECEPTOR / ENDOTHELIN RECEPTOR / G-PROTEIN COUPLED RECEPTOR / REGULATOR OF G-PROTEIN SIGNALING (RGS) / 耐性 / 細胞内Ca+移動 / 細胞内Ca^+移動 / G蛋白質シグナル調節蛋白質(RGS) / 逆耐性 / 脱感作(耐性) / 細胞内Ca2+移動 / G蛋白質情報伝達系 / G蛋白質シグナル調箇蛋白質(RGS) / superior cervical ganglion / electron microscopy / synaptic spinule / perforated synapse / synapse remodeling / long-term potentiation / synaptic plasticity / パーフォレイテッド・シナプス / 刺激後増強 / 上頚神経節 / 上頸神経節 / 電子顕微鏡 / シナプス小棘 / 解離性シナプス / シナプス再構築 / 長期増強 / シナプス可塑性 / Regulators of G protein signaling / Binding experiment / Desensitization / Endothelin receptor antagonists / Endothelin receptors / 結合実験 / G蛋白質シグナル調節因子(RGS) / エンドセリン拮抗薬 / Hirschsprung disease / Endothelin receptor / 平滑筋 / 血管 / Hirshsprung病 / エンドセリンレセプター / 国際情報交流 / 「国際情報交換」 / スピノフィリン / 閉経後高血圧 / バイオインフオーマティクス / G蛋白質共役受容 / G蛋白質共役受容体 / in silico / G蛋白質共役型受容体 / 生合成経路 / ボンベシン受容体 / リガンド予測 / リガンド Less
  • Research Projects

    (12 results)
  • Research Products

    (19 results)
  • Co-Researchers

    (8 People)
  •  A study on inhibitory regulation of urotensin II receptor signaling by RGS proteins: an attempt to find potential novel anti-arteriosclerotic agentsPrincipal Investigator

    • Principal Investigator
      NISHIYAMA Mariko
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General pharmacology
    • Research Institution
      Chiba University
  •  Analysis of a novel mechanism responsible for postmenopausal hypertension

    • Principal Investigator
      KIMURA Sadao
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Chiba University
  •  In silico searching for biologically active peptides with a C-terminal amide based on h uman genome DNA structure

    • Principal Investigator
      KIMURA Sadao
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Chiba University
  •  An exhaustive search of new bioactive peptides based on prediction by bioinformatics using human genome structures

    • Principal Investigator
      KIMURA Sadao
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Chiba University
  •  オーファン受容体リガンドの新しい高感度アッセイ法による探索

    • Principal Investigator
      木村 定雄
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      General pharmacology
    • Research Institution
      Chiba University
  •  The role of energy metabolic abnormality in cardiac hypertrophy.

    • Principal Investigator
      KASUYA Yoshitoshi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      体育学
    • Research Institution
      Chiba University
  •  ANALYSIS OF REGURATORY MECHANISM OF RGS ON DESENSITIZATION AND TORERANCE.

    • Principal Investigator
      MORIO Kayoko
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      CHIBA UNIVERSITY
  •  Regulation of G protein-signaling by RGS proteins in cardiovascular system

    • Principal Investigator
      KIMURA Sadao
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      CHIBA UNIVERSITY
  •  Functional morphology on the synaptic plasticity : Rapid remodeling of the synapse during long-term potentiation.

    • Principal Investigator
      KADOTA Tomoko
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Chiba University
  •  Analysis of the mechanism by nobel regulators of endothelin receptor signaling

    • Principal Investigator
      KIMURA Sadao
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      Chiba University Graduate School of Medicine
  •  血管収縮に関与する新しいエンドセリンB受容体サブタイプの特性と生理的意義Principal Investigator

    • Principal Investigator
      西山 真理子
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      血管生物学
    • Research Institution
      Chiba University
  •  Cloning of new endothelin B receptor and its physiological significance

    • Principal Investigator
      KIMURA Sadao
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Chiba University

All 2014 2013 2012 2011 2010 2006 2005

All Journal Article Presentation Book

  • [Book] In silico search for biologically active peptides. in "Handbook of the Biologically Active Peptides", 2nd edition(edited by Kastin AJ)2013

    • Author(s)
      Nishiyama M, Ishii M, Hirose S, Yamasaki H, Kimura S
    • Publisher
      Academic Press(Chapter 239)
    • Data Source
      KAKENHI-PROJECT-23590296
  • [Book] Handbook of the Biologically Active Peptides2013

    • Author(s)
      Nishiyama M, Ishii M, Hirose S, Yamasaki H, Kimura S
    • Publisher
      Academic Press
    • Data Source
      KAKENHI-PROJECT-23590296
  • [Journal Article] Potent and selective inhibition of angiotensin AT1 receptor signalling by RGS2: roles of its N-terminal domain2011

    • Author(s)
      Matsuzaki N, Nishiyama M, Song D, Moroi K, Kimura S
    • Journal Title

      Cellular Signalling

      Volume: Vol.23、No.6 Issue: 6 Pages: 1041-1049

    • DOI

      10.1016/j.cellsig.2011.01.023

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590296
  • [Journal Article] Potent and selective inhibition of angiotensin AT1 receptor signalling by RGS2 : Roles of its N-terminal domain.2011

    • Author(s)
      Matsuzaki N, Nishiyama M, Song D, Moroi K, Kimura S
    • Journal Title

      Cellular Signalling 23(6)

      Pages: 1041-1049

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590248
  • [Journal Article] Potent and selective inhibition of angiotensin AT1 receptor signaling by RGS2 : Roles of its N-terminal dolnain.2011

    • Author(s)
      atsuzaki N, Nishiyama M, Song D, Moroi K, Kimura S
    • Journal Title

      Cellular Signalling

      Volume: 23 Pages: 1041-1049

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590248
  • [Journal Article] Involvement of p38alpha mitogen-activated protein kinase in lung metastasis of tumor cells.2006

    • Author(s)
      Matsuo Y, Amano S, Furuya M, Namiki K, Sakurai K, Nishiyama M, Sudo T, Tatsumi K, Kuriyama T, Kimura S, Kasuya Y.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 36767-36775

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590214
  • [Journal Article] Involvement of p38alpha mitgen-activayed protein kinase in lung metastasis of tumor cells.2006

    • Author(s)
      Matsuo Y, Amano S, Furuya M, Namiki K, Sakurai K, Nishiyama M, Sudo T, Tatsumi K, Kuriyama T, Kimura S, Kasuya Y
    • Journal Title

      J. Biol. Chem. 281・48

      Pages: 36767-36775

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590214
  • [Journal Article] Pathophysiology of Tumor Neovascularization.2005

    • Author(s)
      Furuya M, Nishiyama M, Kasuya Y, Kimura S, Ishikura H
    • Journal Title

      Vasc.Health Risk Management 1・4

      Pages: 277-290

    • Data Source
      KAKENHI-PROJECT-17590214
  • [Journal Article] Pathophysiology of Tumor Neovascularization.2005

    • Author(s)
      Furuya M, Nishiyama M, Kasuya Y, Kimura S, Ishikura H
    • Journal Title

      Vasc. Health Risk Management I(4)

      Pages: 277-290

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590214
  • [Journal Article] Pathophysiology of Tumor Neovascularization.2005

    • Author(s)
      Furuya M, Nishiyama M, Kasuya Y, Kimura S, Ishikura H
    • Journal Title

      Vasc. Health Risk Management 1・4

      Pages: 277-290

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590214
  • [Presentation] 血管作動性ペプチド受容体のカルシウム応答に対するRGS8の強力な抑制効果: RGSドメインのC末端部分の重要性2014

    • Author(s)
      西山眞理子、住宮菜弥香、木村定雄
    • Organizer
      日本薬理学会
    • Place of Presentation
      仙台国際センター
    • Data Source
      KAKENHI-PROJECT-23590296
  • [Presentation] Potent inhibitory effects of RGS8 on intracellular calcium responses to vasoactive peptides: importance of the C-terminal part of its RGS domain2014

    • Author(s)
      Mariko Nishiyama, Sayaka Sumimiya, Sadao Kimura
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター
    • Data Source
      KAKENHI-PROJECT-25670125
  • [Presentation] 血管作動性ペプチド受容体のカルシウム応答に対するRGS8の強力な抑制効果:RGSドメインのC末端部分の需要性2014

    • Author(s)
      西山眞理子, 住宮菜弥香, 木村定雄
    • Organizer
      第87回日本薬理学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2014-03-20
    • Data Source
      KAKENHI-PROJECT-23590296
  • [Presentation] 血管作動性ペプチド受容体のカルシウム応答に対するRGS2、RGS3及びRGS8の強力な抑制効果2012

    • Author(s)
      宋丹、西山眞理子、木村定雄
    • Organizer
      日本薬理学会年会
    • Place of Presentation
      京都国際会館
    • Data Source
      KAKENHI-PROJECT-23590296
  • [Presentation] 血管作動性ペプチド受容体のカルシウム応答に対するRGS2, RGS3, RGS8の強力な抑制効果2012

    • Author(s)
      宋丹, 西山眞理子, 木村定雄
    • Organizer
      第85回日本薬理学会総会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-14
    • Data Source
      KAKENHI-PROJECT-23590296
  • [Presentation] RGS2の選択的なアンジオテンシンAT1受容体シグナリング抑制効果におけるN末端部サブドメインの役割2011

    • Author(s)
      松崎直子・西山眞理子・宋丹・諸井佳代子・木村定雄
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-24
    • Data Source
      KAKENHI-PROJECT-20590248
  • [Presentation] RGS2の選択的なアンジオテンシンATI受容体シグナリング抑制効果におけるN末端サブドメインの役割2011

    • Author(s)
      松崎直子, 西山真理子, 諸井佳代子, 木村定雄
    • Organizer
      日本薬理学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-03-24
    • Data Source
      KAKENHI-PROJECT-20590248
  • [Presentation] RGS2の選択的なAT1a受容体シグナリング抑制効果-RGS2のN末端部の役割-2010

    • Author(s)
      松崎直子、西山真理子、諸井佳代子、木村定雄
    • Organizer
      日本薬理学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-03-16
    • Data Source
      KAKENHI-PROJECT-20590248
  • [Presentation] RGS2の選択的なAT1受容体シグナリング抑制効果-RGS2のN末端ドメインの役割-2010

    • Author(s)
      松崎直子・西山眞理子・諸井佳代子・木村定雄
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2010-03-16
    • Data Source
      KAKENHI-PROJECT-20590248
  • 1.  KIMURA Sadao (40134225)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 19 results
  • 2.  MOROI Kayoko (80110352)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 3.  KASUYA Yoshitoshi (70221877)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 5 results
  • 4.  KADOTA Tomoko (00089864)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  USUI Hirokazu (90375634)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  MIYAUCHI Takashi (60222329)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  MATUDA Mituo (20110702)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  SAIDO Takaomi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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