Miyauchi Takashi 宮内卓

… Alternative Names

Researcher Number	60222329
Other IDs
External Links
Affiliation (Current)	2021: 筑波大学, 医学医療系, 教授
Affiliation (based on the past Project Information) *help	2012 – 2019: 筑波大学, 医学医療系, 教授 2007 – 2008: 筑波大学, 大学院・人間総合科学研究科, 教授 2006: 筑波大学, 大学院人間総合科学研究科, 教授 2004 – 2005: 筑波大学, 大学院・人間総合科学研究科, 教授 2004: 国立大学法人筑波大学, 大学院・人間総合科学研究科, 教授 … More
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Sports science / Applied pharmacology / General pharmacology Except Principal Investigator 体育学 / Circulatory organs internal medicine / Sports science / Environmental pharmacy / Cardiovascular surgery / Applied pharmacology / 応用薬理学・医療系薬学 / Digestive surgery
Keywords	Principal Investigator エンドセリン / 心不全 / 薬理学 / 分子生物学 / 心肥大 / endothelin / エンドセリン拮抗薬 / 肺高血圧 / 循環器疾患 / 高血圧 … More Except Principal Investigator エンドセリン / 心不全 / endothelin / 一酸化窒素 / エンドセリン受容体遮断薬 / 心肥大 / heart failure / 循環器疾患 / 中高齢者 / 肺高血圧症 / エンドセリン拮抗薬 / cardiac hypertrophy / 不整脈 / 電気的興奮 / mechanical contraction / 運動トレーニング / exercise training / エンドセリン-1 / ディーゼル排出微粒子 / キノン系化合物 / 血管調節 / 動脈伸展性 / 加齢 / 血管内皮機能 / マイクロアレイ / 放射光微小血管撮影法 / シアストレス / 肺血管拡張薬 / endothelin antagonist / 機械的収縮 / フィードバック / フィードバック機構 / arrhythmia / excitation / ion channel / HIF-1α / 血流再配分 / arterial compliance / endothelin receptor antagonist / SB209670 / 大動脈 / aorta / PPAR-α / JNK / mRNA / エンドセリン-3 / ノルエピネフリン / バゾプレッシン / 運動負荷 / 運動強度 / 水分摂取 / 環境化学物質 / 有酸素性運動 / 肥満 / 中心動脈伸展性 / 有酸素性運動トレーニング / 頸動脈コンプライアンス / 交感神経 / 中高年者 / ANP / 遺伝子多型 / 動脈スティフネス / 身体活動量 / 運動効果 / エストロゲン / エストロゲン受容体遺伝子多型 / 身体活動水準 / 性差 / マイクロRNA / マイクロＲＮＡ / 低酸素 / 好感度放射光微小血管造影 / シアーストレス / 高感度放射光微小血管造影 / 循環薬理学 / 病態生理学 / 分子生物学 / cardiovascular pharmacology / pathophysiology / molecular biology / 肺高血圧 / 薬理学 / エンドセリレ拮抗薬 / 新治療法 / cardiovascular diseases / pulmonary hypertension / pharmacology / 伸展刺激応答イオンチャンネル / 自律神経 / 肥大心 / Cardiac hypertrophy / stretch acfivated ion channel / antonomic nerves / イオンチャンネル / 分子循環器病学 / 自立神経 / feedback / 慢性循環器疾患 / 心筋梗塞 / 慢性心不全 / リモデリング / ET受容体拮抗薬 / 心筋症ハムスター / 受容体 / 受容体拮抗薬 / アポトーシス / ミトコンドリア / 動脈硬化 / upregulation / 心筋梗塞ラット / 変換酵素 / エンドセリン受容体 / 免疫組織化学 / chronic circulatory disease / myocardial infarction / chronic heart failure / cardiac remodeling / cardiomyopathic hamster / ET receptor antagonist / 運動 / 血管内皮細胞 / クロストーク / 水泳トレーニング / 血管伸展性 / 内皮型一酸化窒素合成酵素 / 脱トレーニング / nitric oxide / exercise / vascular endntlielial cell / cross talk / aging / イオンチャンネル / 機械的収縮機構 / 心磁図 / 相互関係 / 不全心筋 / 自律神経システム / 機械的收縮機構 / arrhythemia / electrical excitation / feed back / interaction / human and animals / エンドセリン受容体拮抗薬 / マイクロソフェアー法 / トレッドミル走 / NOx / 慢性運動トレーニング / VO_2max / redistribution of blood flow / microshere / treadmill / 肝微小循環 / 肝阻血再灌流障害 / エンドセリン拮抗剤 / 中心静脈血流 / 類洞血流 / 白血球膠着 / 肝機能障害 / 肝阻血再潅流障害 / 中心静脈血行 / 胆汁排泄 / 肝酵素 / liver microcirculation / ischemia-reperfusion injury / central venous flow / sinusoid perfusion / leukocyte adhesion / liver dysfunction / 9,10-フェナントラキノン / 血管内皮機能障害 / NO / 後期高齢者 / 動脈系伸展性 / 身体活動 / 運動トレーニンゲ / older human / elderly human / physical activity / vascular endothelial function / fenofibrate / エンドセリン(ET)-1 / ラット心筋細胞 / 冠動脈結紮モデルラット / MAPキナーゼ / Fenofibrate / Endothelin(ET)-1 / rat cardiomyocytes / aortic banding model / MAP kinases / 血管拡張・収縮因子 / 大動脈伸展性 / 心臓 / プロスタグランディン / CNP / eNOS / 遺伝子 / vasoactive factor / arterial stiffness / heart / 微小血管撮影法 / 放射光 Less

放射光微小血管撮影法を用いた肺高血圧症における微小肺細動脈リモデリング解析
- Principal Investigator
  
  徳永千穂
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular surgery
- Research Institution
  Saitama Medical University
  University of Tsukuba
Synchrotron radiation pulmonary micro-angiography for evaluating micro-vasculature remodeling and endothelial dysfunction in pulmonary arterial hypertension.
- Principal Investigator
  
  TOKUNAGA CHIHO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular surgery
- Research Institution
  University of Tsukuba
Altered expression of miRNA and gene expression in lungs of pulmonary arterial hypertension
- Principal Investigator
  
  SAKAI SATOSHI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  University of Tsukuba
Effects of endothelin B receptor blockade on the vascular smooth muscles of the pulmonary hypertensive animalsPrincipal Investigator
- Principal Investigator
  
  MIYAUCHI TAKASHI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  University of Tsukuba
The mechanisms underlying habitual exercise-induced increase in arterial compliance : the relation between regular exercise and vascular endothelial function
- Principal Investigator
  
  MAEDA Seiji
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Sports science
- Research Institution
  University of Tsukuba
動脈硬化改善に対する運動効果の個人差を規定する新規遺伝子の探索
- Principal Investigator
  
  前田清司
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Sports science
- Research Institution
  University of Tsukuba
Molecular mechanisms underlying exercise training-induced reduction of aortic stiffness
- Principal Investigator
  
  MAEDA Seiji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Sports science
- Research Institution
  University of Tsukuba
スポーツ心臓の心肥大と心臓病の心肥大の成立機構の差違に関する分子生物学的研究Principal Investigator
- Principal Investigator
  
  宮内卓
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Sports science
- Research Institution
  University of Tsukuba
Molecular pharmacological study and development of new treatment by investigating endothelin in cardiovascular diseases.Principal Investigator
- Principal Investigator
  
  MIYAUCHI Takashi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  University of Tsukuba
Effect of physical activity on systemic arterial compliance: a cross-sectional and a longitudinal study in older humans
- Principal Investigator
  
  MATSUDA Mitsuo
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  体育学
- Research Institution
  University of Tsukuba
The role of energy metabolic abnormality in cardiac hypertrophy.
- Principal Investigator
  
  KASUYA Yoshitoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  体育学
- Research Institution
  Chiba University
Protection of hepatic microcirculatory disturbance due to the ischemia-reperfusion injury
- Principal Investigator
  
  TODOROKI Takeshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  University of Tsukuba
ディーゼル排出微粒子成分であるフェナントラキノンによる血管調節系の破綻
- Principal Investigator
  
  熊谷嘉人
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  University of Tsukuba
Molecntan biological and pharmaco-physiological approach to pathophysiological roles of endothelin-1 in aggrarating heart failurePrincipal Investigator
- Principal Investigator
  
  MIYAUCHI Takashi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Tsukuba
Involvement of centhrachen-excitation feedback mechanism in arrhythmia in hear failure
- Principal Investigator
  
  YAMAGUCHI Iwa
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Tsukuba
ROLES BIOACTIVE PEPTIDE IN EXERCISE-INDUCED REDISTRIBUTION OF TISSUE BLOOD FLOW OF INTERNAL ORGANS AND MUSCLES
- Principal Investigator
  
  IRUKAYAMA-TOMOBE Yoko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  体育学
- Research Institution
  Department of Sports Medicine, Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan
環境物質であるキノン系化合物の曝露による生体内NOの産生低下と循環器疾患の誘発
- Principal Investigator
  
  熊谷嘉人
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  University of Tsukuba
Exploration of the novel therapeutic methods for the treatment of chronic circulatory diseases
- Principal Investigator
  
  GOTO Katsutoshi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  University of Tsukuba
Exercise and regulation of circulatory system by endothelium-derived vasoactive substances
- Principal Investigator
  
  MATSUDA Mitsuo
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  体育学
- Research Institution
  University of Tsukuba
Molecular pharmacological approach to roles of endothelin in heart failure and deverlopmet of new tehrapeuetin strategyPrincipal Investigator
- Principal Investigator
  
  MIYAUCHI Takashi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Tsukuba
エンドセリン拮抗薬を用いた心不全に対する新治療法の開発のための分子薬理学的研究Principal Investigator
- Principal Investigator
  
  宮内卓
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Tsukuba
Contraction-excitation feedback in heart failure and cardiac hypertrophy
- Principal Investigator
  
  YAMAGUCHI Iwao
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Tsukuba
Molecular biological study of pathophysiological roles of endothelin in heart failure and the development of a new treatment based on these findingsPrincipal Investigator
- Principal Investigator
  
  MIYAUCHI Takashi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Tsukuba
心疾患に合併した肺高血圧に対する新治療法の開発のための疾患モデル動物を用いた研究-内因性センドセリンの病態生理液役割の解明とその拮抗薬を用いた新治療法の開発-Principal Investigator
- Principal Investigator
  
  宮内卓
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Tsukuba
The study of pathophysiological roles of endothelin in heart failure and cardiac hypertrophy and the development of a new treatment based on these findings
- Principal Investigator
  
  SUGISHITA Yasuro
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Tsukuba
Basic research for the development of the new treatment using endothelin receptor antagonists in cardiovascular diseases
- Principal Investigator
  
  SUGISHITA Yasuro
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Tsukuba
肥大心における機械的収縮、電気的興奮のフィードバック機構の不整脈発生に対する関与-Stretch activated channel の関与と自律神経が与える影響について-
- Principal Investigator
  
  YAMAGUCHI Iwao
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Institute of Clinical Medicine, University of Tsukuba
長時間運動による血漿エンドセリン濃度変動の生理的意義
- Principal Investigator
  
  MATSUDA Mitsuo
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  体育学
- Research Institution
  University of Tsukuba
肺高血圧症患者及びそのモデル動物の病態生理における内因性エンドセリンの役割Principal Investigator
- Principal Investigator
  
  宮内卓
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Tsukuba

All 2016 2014 2013 2012 2009 2007 2006 2005 2004 2002 2001 Other

All Journal Article Presentation Book

[Book] 新世代の循環器薬物療法2004
- Author(s)
  宮内卓, 他
- Total Pages
  501
- Publisher
  メジカルレビュー社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390077
[Book] Annual Review 2002循環器2002
- Author(s)
  酒井俊, 宮内卓
- Total Pages
  282
- Publisher
  中外医学社(編集者:杉下靖郎,門間和夫,矢崎義雄,高本眞一)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12470147
[Journal Article] Antagonists to endothelin receptor type B promote apoptosis in human pulmonary arterial smooth muscle cells2016
- Author(s)
  Sakai S, Maruyama H, Kimura T, Tajiri K, Honda J, Homma S, Aonuma K, Miyauchi T
- Journal Title
  
  Life Sci
  
  Volume: in press Pages: 116-120
- DOI
  10.1016/j.lfs.2016.03.044
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293125, KAKENHI-PROJECT-15K15318, KAKENHI-PROJECT-16H05220
[Journal Article] Calcitonin gene-related peptide protects the myocardium from ischemia induced by endothelin-1 : Intravital microscopic observation and 31P-MR spectroscopic studies.2014
- Author(s)
  Homma S, Kimura T, Sakai S, Yanagi KI, Miyauchi Y, Aonuma K, Miyauchi T
- Journal Title
  
  Life Sci.
  
  Volume: (in press) Pages: 248-254
- DOI
  10.1016/j.lfs.2014.02.024
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23500835, KAKENHI-PROJECT-24590654, KAKENHI-PROJECT-25293125, KAKENHI-PROJECT-25670757
[Journal Article] Endothelin receptor antagonist exacerbates myocarditis in mice.2014
- Author(s)
  Tajiri K, Sakai S, Kimura T, Machino-Ohtsuka T, Murakoshi N, Xu D, Wang Z, Sato A, Miyauchi T, Aonuma K
- Journal Title
  
  Life Sci.
  
  Volume: (in press) Pages: 288-296
- DOI
  10.1016/j.lfs.2014.01.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23500835, KAKENHI-PROJECT-24590654, KAKENHI-PROJECT-25293125, KAKENHI-PROJECT-25670757
[Journal Article] Effects of selective endothelin (ET)-A receptor antagonist versus dual ET-A/B receptor antagonist on hearts of streptozotocin-treated diabetic rats.2014
- Author(s)
  Miyauchi Y, Jesmin S, Sakai S, Kamiyama J, Shimojo N, Rahman A, Islam M, Zaedi S, Maeda S, Maruyama H, Mizutani T, Homma S, Aonuma K, Miyauchi T.
- Journal Title
  
  Life Sci.
  
  Volume: 111(1-2) Pages: 6-11
- DOI
  10.1016/j.lfs.2014.06.008
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24406026, KAKENHI-PROJECT-24590654, KAKENHI-PROJECT-25305034
[Journal Article] Involvement of peptidyl-prolyl isomerase Pin1 in the inhibitory effect of fluvastatin on endothelin-1-induced cardiomyocyte hypertrophy2014
- Author(s)
  Sakai S, Shimojo N, Kimura T, Tajiri K, Maruyama H, Homma S, Kuga K, Mizutani T, Aonuma K, Miyauchi T.
- Journal Title
  
  Life Sciences
  
  Volume: 102 Pages: 98-104
- DOI
  10.1016/j.lfs.2014.03.018
- NAID
  120005456068
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23500835, KAKENHI-PROJECT-23592025, KAKENHI-PROJECT-24590654, KAKENHI-PROJECT-25293125, KAKENHI-PROJECT-25670757
[Journal Article] Fish oil constituent eicosapentaenoic acid inhibits endothelin-induced cardiomyocyte hypertrophy via PPAR-α.2014
- Author(s)
  Shimojo N, Jesmin S, Sakai S, Maeda S, Miyauchi T, Mizutani T, Aonuma K, Kawano S
- Journal Title
  
  Life Sciences
  
  Volume: (in press) Pages: 173-178
- DOI
  10.1016/j.lfs.2014.04.025
- NAID
  120005555622
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23500835, KAKENHI-PROJECT-23592025, KAKENHI-PROJECT-24406026, KAKENHI-PROJECT-24590654, KAKENHI-PROJECT-25293125
[Journal Article] Clinical value of plasma pentraxin 3 levels for predicting cardiac troponin elevation after percutaneous coronary intervention.2013
- Author(s)
  Wang Z, Sato A, Akiyama D, Kimura T, Tajiri K, Hoshi T, Sakai S, Koike A, Miyauchi T, Aonuma K.
- Journal Title
  
  Life Sci.
  
  Volume: 95 Pages: 40-44
- DOI
  10.1016/j.lfs.2013.11.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293125
[Journal Article] Increased plasma levels of big-endothelin-2 and big-endothelin-3 in patients with end-stage renal disease.2012
- Author(s)
  Miyauchi Y
- Journal Title
  
  Life Sciences
  
  Volume: 91 Pages: 729-732
- DOI
  10.1016/j.lfs.2012.08.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590654
[Journal Article] Involvement of endothelin-1 in habitual exercise-induced increase in arterial compliance2009
- Author(s)
  Seiji Maeda, Jun Sugawara, Mutsuko Yoshizawa, Takeshi Otsuki, Nobutake Shimojo, Subrina Jesmin, Ryuichi Ajisaka, Takashi Miyauchi, Hirofumi Tanaka
- Journal Title
  
  Acta Physiologica 196
  
  Pages: 223-229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300215
[Journal Article] Systemic α-adrenergic and nitric oxide inhibition on basal limb blood flow : effects of endurance training in middle-aged and older adults2007
- Author(s)
  Jun Sugawara, Hidehiko Komine, Koichiro Hayashi, Mutsuko Yoshizawa, Takeshi Otsuki, Nobutake Shimojo, Takashi Miyauchi, Takashi Yokoi, Seiji Maeda, Hirofumi Tanaka
- Journal Title
  
  American Journal of Physiology : Heart and Circulatory Physiology 293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300215
[Journal Article] Effect of systemic nitric oxide synthase inhibition on arterial stiffness in humans2007
- Author(s)
  Jun Sugawara, Hidehiko Komine, Koichiro Hayashi, Mutsuko Yoshizawa, Takashi Yokoi, Takeshi Otsuki, Nobutake Shimojo, Takashi Miyauchi, Seiji Maeda, Hirofumi Tanaka
- Journal Title
  
  Hypertension Research 30
  
  Pages: 411-415
- NAID
  10019537222
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300215
[Journal Article] Polymorphism in endothelin-related genes limits exercise-induced decreases in arterial stiffness in older subjects2006
- Author(s)
  Iemitsu M, Maeda S, Otsuki T, Sugawara J, Tanabe T, Jesmin S, Kuno S, Ajisaka R, Miyauchi T, Matsuda M.
- Journal Title
  
  Hypertension 47
  
  Pages: 928-936
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390077
[Journal Article] Eicosapentaenoic acid prevents endothelin-1-induced cardiomyocyte hypertrophy in vitro through the suppression of TGF-β1 and phosphorylated JNK2006
- Author(s)
  Shimojo N, Jesmin S, Zaedi S, Maeda S, Soma M, Aonuma K, Yamaguchi I, Miyauchi T.
- Journal Title
  
  American Journal of Physiology. Heart and Circulatory Physiology 291
  
  Pages: 835-845
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390077
[Journal Article] Aortic stiffness and aerobic exercise : mechanistic insight from microarray analyses.2005
- Author(s)
  Maeda S, Miyauchi T, et al.
- Journal Title
  
  Medicine & Science in Sports & Exercise 37
  
  Pages: 1710-1716
- Data Source
  KAKENHI-PROJECT-15650130
[Journal Article] Acute exercise causes an enhancement of tissue renin-angiotensin system in the kidney in rats2005
- Author(s)
  Maeda S, Miyauchi T, et al.
- Journal Title
  
  Acta Physiologica Scandinavica 185
  
  Pages: 79-86
- Data Source
  KAKENHI-PROJECT-15650130
[Journal Article] Acute exercise causes an enhancement of tissue renin-angiotensin system in the kidney in rats2005
- Author(s)
  Maeda S, Iemitsu M, Jesmin S, Miyauchi T.
- Journal Title
  
  Acta Physiologica Scanginavica 185
  
  Pages: 79-86
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390077
[Journal Article] Gene expression profiling of exercise-induced cardiac hypertrophy in rats.2005
- Author(s)
  Iemitsu M, Maeda S, Miyauchi T, et al.
- Journal Title
  
  Acta Physiologica Scandinavica 185
  
  Pages: 259-270
- Data Source
  KAKENHI-PROJECT-15650130
[Journal Article] Emergence of clinical applications of endothelin system inhibitors.2004
- Author(s)
  Goto K, Miyauchi T, et al.
- Journal Title
  
  Journal of Cardiovascular Pharmacololgy 44
  
  Pages: 13-14
- Data Source
  KAKENHI-PROJECT-15390077
[Journal Article] Characterization of regional cerebral blood flow and expression of angiogenic growth factors in the frontal cortex of juvenile male SHR-SP and SHR.2004
- Author(s)
  Jesmin S, Miyauchi T, et al.
- Journal Title
  
  Brain Research 1030
  
  Pages: 172-182
- Data Source
  KAKENHI-PROJECT-15390077
[Journal Article] Time course alteration of endothelin-1 gene expression in the heart during exercise and recovery from post-exercise periods in rats.2004
- Author(s)
  Iemitsu M, Miyauchi T, et al.
- Journal Title
  
  Journal of Cardiovascular Pharmacology 44
- Data Source
  KAKENHI-PROJECT-15650130
[Journal Article] Myocardial fibrosis and diastolic dysfunctiuon in deoxycorticosterone acetate-salt hypertensive rats is ameliorated by the peroxisome proliferator-activated receptor alpha activator fenofibrate, partly by suppressing inflammatory responses associated with the nuclear factor-kappa-B pathway2004
- Author(s)
  Ogata T, Miyauchi T, et al.
- Journal Title
  
  Journal of the American College of Cardiology 43
  
  Pages: 1481-1488
- Data Source
  KAKENHI-PROJECT-15390077
[Journal Article] Endothelin-1-induced cardiac hypertrophy is inhibited by activation of peroxisome proliferator-activated receptor-α partly via blockade of c-Jun NH2-terminal kinase pathway.2004
- Author(s)
  Irukayama-Tomobe Y, Miyauchi T, et al.
- Journal Title
  
  Circulation 109
  
  Pages: 904-910
- Data Source
  KAKENHI-PROJECT-15650130
[Journal Article] Endothelin-1-induced cardiac hypertrophy is inhibited by activation of peroxisome proliferator-activated receptor-α partly via blockade of c-Jun NH2-terminal kinase pathway.2004
- Author(s)
  Irukayama-Tomobe Y, Miyauchi T, et al.
- Journal Title
  
  Circulation 109
  
  Pages: 904-910
- Data Source
  KAKENHI-PROJECT-15390077
[Journal Article] Chronic administration of an endothelin-A receptor antagonist improves exercise capacity in rats with myocardial infarction-induced congestive heart failure.2004
- Author(s)
  Miyauchi T. et al.
- Journal Title
  
  Journal of Cardiovascular Pharmacology 44
- Data Source
  KAKENHI-PROJECT-15650130
[Journal Article] Chronic administration of an endothelin-A receptor antagonist improves exercise capacity in rats with myocardial infarction-induced congestive heart failure。2004
- Author(s)
  Miyauchi T, Fujimori A, et al.
- Journal Title
  
  Journal of Cardiovascular Pharmacololgy 44
- Data Source
  KAKENHI-PROJECT-15390077
[Journal Article] Exercise training improves cardiac function-related gene levels through thyroid hormone receptor signaling in aged rats.2004
- Author(s)
  Iemitsu M, Miyauchi T, et al.
- Journal Title
  
  American Journal of Physiology : Heart and Circulatory Physiology 286
- Data Source
  KAKENHI-PROJECT-15650130
[Journal Article] Chronic administration of an endothelin-A receptor antagonist improves exercise capacity in rats with myocardial infarction-induced congestive heart failure2004
- Author(s)
  Miyauchi T, Fujimori A, Maeda S, Iemitsu M, Sakai S, Shikama H, Tanabe T, Matsuda M, Goto K, Yamaguchi I.
- Journal Title
  
  Journal of Cardiovascular Pharmacology 44
  
  Pages: 64-67
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390077
[Journal Article] Endothelin-1-induced cardiac hypertrophy is inhibited by activation of peroxisomeproliferator-activated receptor-α partly via blockade of c-Jun NH2-terminal kinase pathway2004
- Author(s)
  Irukayama-Tomobe Y, Miyauchi T, Sakai S, Kasuya Y, Ogata T, Takanashi M, Iemitsu M, Sudo T, Goto K, Yamaguchi I.
- Journal Title
  
  Circulation 109
  
  Pages: 904-910
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390077
[Journal Article] Moderate regular exercise increases basal production of nitric oxide in elderly women.2004
- Author(s)
  Maeda S, Miyauchi T, et al.
- Journal Title
  
  Hypertension Research 27
  
  Pages: 947-953
- NAID
  10014466824
- Data Source
  KAKENHI-PROJECT-15650130
[Journal Article] Chronic administration of an endothelin-A receptor antagonist improves exercise capacity in rats with myocardial infarction-induced congestive heart failure.2004
- Author(s)
  Miyauchi T, et al.
- Journal Title
  
  Journal of Cardiovascular Pharmacology. 44
  
  Pages: 64-67
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390077
[Journal Article] Endothelin receptor antagonist reverses decreased NO system in the kidney in vivo during exercise.2004
- Author(s)
  Maeda S, Miyauchi T. et al.
- Journal Title
  
  American Journal of Physiology : Endocrinology and Metabolism 286
- Data Source
  KAKENHI-PROJECT-15650130
[Journal Article] Establishment of hypoxia inducible factor-1α overexpressing cells that produce endothelin-12004
- Author(s)
  Takanashi M, Miyauchi T, Kakinuma Y, Goto K, Yamaguchi I.
- Journal Title
  
  Journal of Cardiovascular Pharmacology 44
  
  Pages: 168-273
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390077
[Journal Article] Exercise training improves cardiac function-related gene levels through thyroid hormone receptor signaling in aged rats.2004
- Author(s)
  Iemitsu M, Miyauchi T, et al.
- Journal Title
  
  American Journal of Physiology 286
- Data Source
  KAKENHI-PROJECT-15390077
[Journal Article] Vascular endothelin-B receptor system in vivo plays a favorable inhibitory role in vascular remodeling after injury revealed by endothelin-B receptor-knockout mice.2002
- Author(s)
  Murakoshi N, Miyauchi T, Kakinuma Y, Ohuchi T, Goto K, Yanagisawa M, Yamaguchi I
- Journal Title
  
  Circulation 106(15)
  
  Pages: 1991-1998
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12470147
[Journal Article] A combination of oral endothelin-A receptor antagonist and oral prostacyclin analogue is superior to each drug alone in ameliorating pulmonary hypertension in rats2002
- Author(s)
  Ueno M, Miyauchi T, et al.
- Journal Title
  
  Journal of the American College of Cardiology vol 40
  
  Pages: 175-181
- NAID
  10010226459
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12470147
[Journal Article] Involvement of endogenour endothelin-1 in exercise-induced redistribution of tissue blood flow : An endothelin receptor antagonist reduces the redistribatier2002
- Author(s)
  Maeda S, Miyauchi T, et al.
- Journal Title
  
  Circulation vol.106
  
  Pages: 2188-2193
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12470147
[Journal Article] Involvement of endogenous endothelin-1 in exercise-induced redistribution of tissue blood flow An endothelin receptor antagonist reduces the redistribution.2002
- Author(s)
  Maeda S, Miyauchi T, Iemitsu M, Tanabe T, Irukayama-Tomobe Y, Goto K, Yamaguchi I, Matsuda M
- Journal Title
  
  Circulation 106(17)
  
  Pages: 2188-2193
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12470147
[Journal Article] Vascular endothelin-B recepton system in vivo plays a favahable inhibitory role in vascular remodeling after injury revealed by endothelin-B receptor Knockoutmice2002
- Author(s)
  Murakoshi N, Miyauchi T, et al.
- Journal Title
  
  Circulation vol.106
  
  Pages: 1991-1998
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12470147
[Journal Article] Aging-induced decrease in the PPAR-α level in hearts is improved by exercise training.2002
- Author(s)
  Iemitsu M, Miyauchi T, Maeda S, Tanabe T, Takanashi M, Irukayama-Tomobe Y, Sakai S, Ohmori H, Matsuda M, Yamaguchi I
- Journal Title
  
  American Journal of Physiology 283(5)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12470147
[Journal Article] A combination of oral endothelin-A receptor antagonist and oral prostacyclin analogue is superior to each drug alone in ameliorating pulmonary hypertension in rats2002
- Author(s)
  Ueno M, Miyauchi T, Sakai S, Yamauchi-Kohno R, Goto K, Yamaguchi I
- Journal Title
  
  Journal of the American College of Cardiology 40(1)
  
  Pages: 175-181
- NAID
  10010226459
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12470147
[Journal Article] Novel molecular mechanism of increased myocardial endothelin-1 expression in the failing heart involving the transcriptional factor hypoxia-inducible factor-1α induced for impaired myocardial energy metabolism.2001
- Author(s)
  Kakinuma Y, Miyauchi T, Yuki K, Murakoshi N, Goto K, Yamguchi I
- Journal Title
  
  Circulation 103(19)
  
  Pages: 2387-2394
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12470147
[Journal Article] Physiological and pathological cardiac hypertrophy induce different nalecular phenotypes in the rat.2001
- Author(s)
  Iemitsu M, Miyauchi T, Maeda S, Sakai S, Kobayashi T, Fujii N, Miyazaki H, Matsuda M, Yamaguchi I
- Journal Title
  
  American Journal of Physiology 281(6)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12470147
[Journal Article] Phenanthraquinone inhibits eNOS activity and suppresses vasorelaxation2001
- Author(s)
  Kumagai Y, Hayashi T, Miyauchi T, et al.
- Journal Title
  
  American Journal of Physiology 281
- Data Source
  KAKENHI-PROJECT-13672340
[Journal Article] A novel pharmacological action of ET-1 to prevent the cytotoxicity of doxorubicin in cardiomyocytes.2001
- Author(s)
  Suzuki T, Miyauchi T
- Journal Title
  
  American Journal of Physiology 280
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12470147
[Journal Article] A novel pharmacological action of ET-1 to prevent the cytotoxicity of doxorubicin in cardiom yocytes2001
- Author(s)
  Suzuki T, Miyauchi T.
- Journal Title
  
  American Journal of Physiology vol280
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12470147
[Journal Article] Physiological and pathological cardiac hypertrophy induce different molecular phenotypes in the rat2001
- Author(s)
  Iemitsu M, Miyauchi T, et. al.
- Journal Title
  
  American Journal of Physiology vol. 281
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12470147
[Presentation] Inhibition of RNA Polymerase II Function by the C-Terminal Domain Phosphatase FCP1 in the Development of Cardiac Dysfunction2014
- Author(s)
  Sakai S, Kimura T, Wang Z, Tajiri K, Maruyama H, Kuga K, Homma S, Miyauchi T, Aonuma K.
- Organizer
  第78回　日本循環器学会学術集会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-25293125
[Presentation] １.エンドセリンの基礎研究から臨床医学へ「－肺高血圧症・心不全などにおけるエンドセリンの役割と遮断薬の効果－」2014
- Author(s)
  宮内　卓
- Organizer
  第2回千駄木心・血管研究会
- Place of Presentation
  東京
- Year and Date
  2014-06-17
- Invited
- Data Source
  KAKENHI-PROJECT-24590654
[Presentation] Selective endothelin (ET)-A receptor antagonist and dual ET-A/B receptor antagonist are effective in preventing the decrease in VEGF signaling and inadequate coronary collateral development in the diabetic hearts.2013
- Author(s)
  Yumi Miyauchi, Subrina Jesmin, Nobutake Shimojo, Seiji Maeda, Satoshi Sakai, Tomoko Yokota, Sohel Zaedi, Taro Mizutani, Satoshi Homma, Kazutaka Aonuma, Takashi Miyauchi.
- Organizer
  The Thirteenth International Conference on Endothelin(Tokyo Japan)
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590654
[Presentation] 運動トレーニングによる中心動脈伸展性の増大にエンドセリンが関与する2007
- Author(s)
  前田清司, 菅原順, 吉澤睦子, 大槻毅, 小峰秀彦, 林貢一郎, 家光素行, 横井孝志, 鰺坂隆一, 宮内卓
- Organizer
  第62回日本体力医学会大会
- Place of Presentation
  秋田
- Year and Date
  2007-09-14
- Data Source
  KAKENHI-PROJECT-18300215
[Presentation] Systemic alpha-adrenergic and nitric oxide inhibition on basal limb blood flow before and after endurance training in aging humans2007
- Author(s)
  Jun Sugawara, Hidehiko Komine, Koichiro Hayashi, Mutsuko Yoshizawa, Takeshi Otsuki, Nobutake Shimojo, Takashi Miyauchi, Takashi Yokoi, Seiji Maeda, Hirofumi Tanaka
- Organizer
  The 54th Annual Meeting of the American College of Sports Medicine
- Place of Presentation
  New Orleans, Louisiana, U.S.A.
- Year and Date
  2007-05-30
- Data Source
  KAKENHI-PROJECT-18300215
[Presentation] ７.POPHで肺動脈圧低下効果が減弱したエポプロステノールの再導入例
- Author(s)
  酒井俊介、酒井　俊、中務智文、丸山秀和、木村泰三、本間　覚、宮内　卓、青沼和隆
- Organizer
  第2回日本肺高血圧学会・第3回日本肺循環学会　合同学術集会
- Place of Presentation
  東京
- Year and Date
  2014-10-03 – 2014-10-05
- Data Source
  KAKENHI-PROJECT-24590654
[Presentation] 右室拡張機能の重要性とその診断法
- Author(s)
  瀬尾由広、山本昌良、木村泰三、石津智子、酒井　俊、宮内　卓、青沼和隆
- Organizer
  第2回日本肺高血圧学会・第3回日本肺循環学会　合同学術集会
- Place of Presentation
  東京
- Year and Date
  2014-10-03 – 2014-10-05
- Data Source
  KAKENHI-PROJECT-24590654
[Presentation] 糖尿病ラット心臓におけるエンドセリンA受容体遮断薬とA/B両遮断薬の効果の検討：心機能とVEGFシグナリングへの影響.
- Author(s)
  宮内裕美、Jesmin Subrina、酒井　俊、下條信威、丸山秀和、本間　覚、水谷太郎、青沼和隆、宮内　卓
- Organizer
  第62回日本心臓病学会学術集会
- Place of Presentation
  仙台
- Year and Date
  2014-09-26 – 2014-09-28
- Data Source
  KAKENHI-PROJECT-24590654
[Presentation] エンドセリンによる肺動脈血管平滑筋のBMPシグナルへの作用
- Author(s)
  丸山秀和、デワヒタ　セリン、酒井　俊、宮内　卓、アスマイ　ベルハジ、ロンドレ　ブノワ、メムリンク　ミリアム、バシェリ　ジャンリュック、ナイエ　ロベール、デワヒタ　ロランス
- Organizer
  第2回日本肺高血圧学会・第3回日本肺循環学会　合同学術集会
- Place of Presentation
  東京
- Year and Date
  2014-10-03 – 2014-10-05
- Data Source
  KAKENHI-PROJECT-24590654

1. GOTO Katsutoshi (30012660)

# of Collaborated Projects: 7 results

# of Collaborated Products: 8 results
2. MATSUDA Mitsuo (20110702)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. MAEDA Seiji (30282346)

# of Collaborated Projects: 6 results

# of Collaborated Products: 10 results
4. SAKAI Satoshi (30282362)

# of Collaborated Projects: 6 results

# of Collaborated Products: 13 results
5. SAKURAI Takeshi (60251055)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. IEMITSU Motoyuki (90375460)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
7. KASUYA Yoshitoshi (70221877)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
8. SUGISHITA Yasuro (90010131)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. YAMAGUCHI Iwao (30111389)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. AJISAKA Ryuichi (70151058)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
11. KUNO Shinya (70242021)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. TOKUNAGA CHIHO (30451701)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 熊谷嘉人 (00250100)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
14. 坂本裕昭 (30611115)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. 兵藤一行 (60201729)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. 松下昌之助 (70359579)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. BUKAWA Hiroki (80173558)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. SUMIDA Takayuki (00183054)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. WARABI Eiji (70396612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. KUGA Keisuke (60241816)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. MIWA Yoshihiro (70263845)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. IRUKAYAMA-TOMOBE Yoko (90312834)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. TODOROKI Takeshi (70114105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. KAWAMOTO Toru (30282354)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. NISHIYAMA Mariko (00092081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. KIMURA Sadao (40134225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 下條信弘 (00080622)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 石川智久 (10201914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 高野博久 (60281698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. MURATA Sakae

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. HIRANO Takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. NISHIKIBE Masaru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 錦辺優

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. HOMMA Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
35. KIMURA Taizo

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
36. SHIMOJO Nobutake

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
37. 田尻和子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
38. JESMIN Subrina

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
39. 水谷太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
40. 久賀圭祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Miyauchi Takashi 宮内 卓

MIYAUCHI TAKASHI 宮内 卓

MIYAUCHI Takashi 宮内 卓

宮内 卓 ミヤウチ タカシ

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Effects of endothelin B receptor blockade on the vascular smooth muscles of the pulmonary hypertensive animalsPrincipal Investigator

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スポーツ心臓の心肥大と心臓病の心肥大の成立機構の差違に関する分子生物学的研究Principal Investigator

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Molecular pharmacological study and development of new treatment by investigating endothelin in cardiovascular diseases.Principal Investigator

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Molecntan biological and pharmaco-physiological approach to pathophysiological roles of endothelin-1 in aggrarating heart failurePrincipal Investigator

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Miyauchi Takashi 宮内卓

MIYAUCHI TAKASHI 宮内卓

MIYAUCHI Takashi 宮内卓

宮内卓ミヤウチタカシ