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Kumagai Yoshito  熊谷 嘉人

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… Alternative Names

KUMAGAI Yosito  熊谷 嘉人

熊谷 嘉人  クマガイ ヨシト

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Researcher Number 00250100
Other IDs
Affiliation (Current) 2019: 筑波大学, 医学医療系, 教授
Affiliation (based on the past Project Information) *help 2011 – 2019: 筑波大学, 医学医療系, 教授
2014: 筑波大学, 大学院人間総合科学研究科, 教授
2007 – 2010: University of Tsukuba, 大学院・人間総合科学研究科, 教授
2006: 筑波大学, 大学院人間総合科学研究科, 教授
2004 – 2005: 筑波大学, 大学院・人間総合科学研究科, 教授 … More
2004: 筑波大学, 医学部・社会学系, 教授
2003: 筑波大学, 医学部, 教授
2003: 筑波大学, 社会医学系, 教授
1998 – 2002: 筑波大学, 社会医学系, 助教授
2000: Isukuba University, School of Medicine, Associate Professor, 医学部, 助教授
1999: 筑波大学, 医学部, 講師
1998: Univ.of Tsukuba Inst.of Community Med.Associate Professor, 社会医学系
1996 – 1997: 筑波大学, 社会医学系, 講師
1993: 国立環境研究所, 主任研究員 Less
Review Section/Research Field
Principal Investigator
Hygiene / Environmental pharmacy / Biological Sciences / Environmental pharmacy / Biological pharmacy / Risk sciences of radiation/Chemicals / Risk sciences of radiation and chemicals / Hygiene / Medium-sized Section 63:Environmental analyses and evaluation and related fields / Broad Section K … More
Except Principal Investigator
… More Environmental pharmacy / 環境影響評価(含放射線生物学) / Public health/Health science / Public health/Health science / Pathological medical chemistry / Circulatory organs internal medicine / Risk sciences of radiation/Chemicals / Hygiene Less
Keywords
Principal Investigator
キノン系化合物 / 一酸化窒素 / 共有結合 / 親電子物質 / 酸化ストレス / 活性イオウ分子 / ディーゼル排出微粒子 / ディーゼル排出粒子 / 循環器疾患 / ヒ素 … More / 化学修飾 / 血管調節 / 大気中ナノ粒子成分 / 親電子性物質 / 大気汚染物質 / 多環芳香族炭化水素キノン類 / ケミカルバイオロジー / チオールケミストリー / メチル水銀 / シグナル伝達 / 翻訳後修飾 / 環境中親電子物質 / 介入研究 / 慢性中毒 / oxidative stress / レドックスシグナル伝達 / エクスポソーム / DT-ジアホラーゼ / 活性酸素 / 環境化学物質 / 気道収縮 / 喘息 / たんぱく質 / 大気汚染 / ナフタレン / 新電子性物質 / 親電子化合物 / 多環芳香族炭化水素キノン体 / S-トランスアリール化 / 環境科学物質 / センサータンパク質 / リスク軽減因子 / 解毒・排泄 / 親電子シグナル / C-S切断酵素 / レドックスセンサー / 大気中揮発物質 / Keap1/Nrf2 / グルタチオン / Nrf2/Keap1システム / S-水銀化 / 硫化水素 / CBS / CSE / 毒性防御 / 解毒 / 化学物質過敏症 / 3,4-ジヒドロクマリン / アミノ基 / 環境応答 / 水銀 / 一酸化窒素合成酵素 / 毒性 / 発現変動 / mercury / nitric oxide synthase / toxicity / alteration in gene expression / 慢性砒素中毒 / 井戸水中砒素 / 井地水中砒素 / サイクリックGMP / 9,10-フェナントラキノン / 血管内皮機能障害 / NO / EGFRリン酸化 / 気管収縮 / 大気中ナノ粒子 / 血管収縮 / diesel exhaust particles / polycyclic aromatic hydrocarbon quinines / covalent attachment / vasorelaxation / tracheal contraction / 井戸水 / 末梢血管障害 / 慢性ヒ素中毒 / ビタミン剤 / 環境疫学 / arsenic / chronic arsenosis / nitric oxide / intervention study / drinking water / 活性酸素種 / レドックスシグナンル伝達 / レドックスカップル / 電子伝達系 / 複合暴露 / レドックスシグナル / イオウ付加体 / 生体内運命 … More
Except Principal Investigator
Nrf2 / HO-1 / NO / 活性酸素 / 一酸化窒素 / 角化症 / 砒素 / 慢性砒素中毒 / Prx I / Fe-NTA / A170 / CD36 / A549 / 高血圧 / 頚動脈硬化 / cGMP / 疫学調査 / 出生コホート / 環境保健 / 感染症 / アレルギー / 栄養学 / 気象学 / 胎児発達 / 小児発達 / 公衆生学 / アレルギー・喘息 / 国際研究者交流 / バングラデシュ / 公衆衛生学 / 生活習慣病 / ベトナム / Garcinia vilersiana / Heme oxygenase-1 / 医薬用植物 / 南方薬 / 生理活性成分 / 転写因子Nrf2 / ホーチミン市 / 癌 / 肝炎 / アルツハイマー病 / 医薬様植物 / 酸化ストレス / シグナル伝達 / レドックス / 親電子 / 1,4-ナフトキノン / 親電子物質 / ストレス応答 / HSP/HSF1 / Keap1/Nrf2 / PTP1B/EGFR / 親電子シグナル / 細胞応答システム / 熱ショックタンパク質 / HSF1 / 動脈硬化 / シトルリン-アルギニンサイクル / 退縮 / アルギナーゼ / NADPHオキシダーゼ / 糖尿病 / 誘導型NO合成酵素(iNOS) / 活性酸素(O_2) / 高脂血症 / 加齢 / Nitric Oxide / Atherosclerosis / Citrolline-Arginine cycle / regression / super oxide anion / arginase / 砒素の地下水汚染 / 色素沈着・脱失 / 慢性中毒 / 介入研究 / 機能障害 / 循環器疾患 / 血管調節 / フェナントラキノン / ニトロキシルラジカル / スルフォラファン / HSP70 / ヒ素 / キノン / Cu,Zn-SOD / パーオキシレドキシン / phenanthraquinone / 発癌性 / 砒素汚染 / 井戸水 / 根絶 / 予防対策 / 中国 / Chronic arsenic poisoning / Hyperkeratosis / Carcinogenic / Oxidative DNA damage / Arsenic contamination / Well water / Extermination / China Less

  • Research Projects

    (31 results)

  • Research Products

    (481 results)

  • Co-Researchers

    (82 People)

  •  環境中親電子物質エクスポソーム研究のモデル化Principal InvestigatorOngoing

    • Principal Investigator
      熊谷 嘉人
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 63:Environmental analyses and evaluation and related fields
    • Research Institution
      University of Tsukuba

  •  Environmental electrophiles exposome and reactive sulfur species as its regulator moleculePrincipal InvestigatorOngoing

    • Principal Investigator
      熊谷 嘉人
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section K
    • Research Institution
      University of Tsukuba

  •  電子伝達系におけるユビキノンと活性イオウ分子とのレドックスカップルの意義Principal InvestigatorOngoing

    • Principal Investigator
      熊谷 嘉人
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      University of Tsukuba

  •  レドックスシグナル伝達の可逆性担保における活性イオウ分子の役割Principal Investigator

    • Principal Investigator
      熊谷 嘉人
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      University of Tsukuba

  •  Comprehensive study on environmental electrophiles-mediated signal transduction pathways regulated by reactive sulfur speciesPrincipal Investigator

    • Principal Investigator
      Kumagai Yoshito
    • Project Period (FY)
      2013 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Risk sciences of radiation and chemicals
    • Research Institution
      University of Tsukuba

  •  Regulatory mechanisms of redox signal transduction mediated by endogenous electrophiles

    • Principal Investigator
      SAWA Tomohiro
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kumamoto University
      Tohoku University

  •  Activation of cellular signal transduction pathways in protective response to an atmospheric electrophile, 1,4-naphthoquinone

    • Principal Investigator
      YASUHIRO Shinkai
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Environmental pharmacy
    • Research Institution
      University of Tsukuba

  •  親電子修飾の制御に働く新奇求核分子としての硫化水素Principal Investigator

    • Principal Investigator
      熊谷 嘉人
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      University of Tsukuba

  •  Exploration of a system for cellular response to the electrophilesexhibiting skin sensitization potentialPrincipal Investigator

    • Principal Investigator
      KUMAGAI Yoshito
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Environmental pharmacy
    • Research Institution
      University of Tsukuba

  •  Development of an assay to evaluate the reactivity at chemicals contaminated in the atmosphere, South CaliforniaPrincipal Investigator

    • Principal Investigator
      KUMAGAI Yoshito
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Environmental pharmacy
    • Research Institution
      University of Tsukuba

  •  活性酸素シグナル伝達を制御するCーS切断酵素Principal Investigator

    • Principal Investigator
      熊谷 嘉人
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      University of Tsukuba

  •  大気中反応物質により非意図的な化学修飾を受けたタンパク質の生体内運命Principal Investigator

    • Principal Investigator
      熊谷 嘉人
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Hygiene
    • Research Institution
      University of Tsukuba

  •  Sensor proteins and cellular protection factors for environmental electrophilesPrincipal Investigator

    • Principal Investigator
      KUMAGAI Yoshito
    • Project Period (FY)
      2008 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      University of Tsukuba

  •  Exploration of bioactive compounds from traditional medicinal plants in Vietnam

    • Principal Investigator
      KANAHO Yasunori
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Environmental pharmacy
    • Research Institution
      University of Tsukuba

  •  Fetal-birth cohort study in Bangladesh : maternal and child nutrition and environment

    • Principal Investigator
      WAGATSUMA Yukiko
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Public health/Health science
    • Research Institution
      University of Tsukuba

  •  Naphthalens that covalently bind to macromolecules contaminated in the atmosphere in southern CaliforniaPrincipal Investigator

    • Principal Investigator
      KUMAGAI Yoshito
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Environmental pharmacy
    • Research Institution
      University of Tsukuba

  •  ディーゼル排出微粒子中に存在する未知の親電子性物質の新規探索法の開発Principal Investigator

    • Principal Investigator
      熊谷 嘉人
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Hygiene
    • Research Institution
      University of Tsukuba

  •  大気中ナノ粒子成分と共有結合して気管収縮を引き起こすタンパク質の同定Principal Investigator

    • Principal Investigator
      熊谷 嘉人
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Hygiene
    • Research Institution
      University of Tsukuba

  •  New evaluation system of cell damage caused by environmental chemicals that effect lifestyle diseases

    • Principal Investigator
      ISHII Tetsuro
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      University of Tsukuba

  •  Biological effect of quinoid compounds causing oxidative stress contaminated in ambient particulate matterPrincipal Investigator

    • Principal Investigator
      KUMAGAI Yoshito
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hygiene
    • Research Institution
      University of Tsukuba

  •  A intervention study for improvement of decreased nitric oxide levels and oxidative stress in arsenosis patients in ChinaPrincipal Investigator

    • Principal Investigator
      KUMAGAI Yoshito
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Environmental pharmacy
    • Research Institution
      University of Tsukuba

  •  Research on the improvement of the chronic arsenic poisoning in China

    • Principal Investigator
      YAMAUCHI Hiroshi
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hygiene
    • Research Institution
      St.Marianna University School of medicine

  •  内モンゴルの慢性砒素汚染地域での介入研究

    • Principal Investigator
      下條 信弘
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      環境影響評価(含放射線生物学)
    • Research Institution
      University of Tsukuba

  •  中国の慢性砒素汚染地域での介入研究:生体内NO産生変動と中毒症状軽減との関係Principal Investigator

    • Principal Investigator
      熊谷 嘉人
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Environmental pharmacy
    • Research Institution
      University of Tsukuba

  •  ディーゼル排出微粒子成分であるフェナントラキノンによる血管調節系の破綻Principal Investigator

    • Principal Investigator
      熊谷 嘉人
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Environmental pharmacy
    • Research Institution
      University of Tsukuba

  •  慢性砒素中毒によるNO産生に係る因子の変動とそれに起因する血管調節系の撹乱

    • Principal Investigator
      下條 信弘
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      環境影響評価(含放射線生物学)
    • Research Institution
      University of Tsukuba

  •  一酸化窒素が高血圧・動脈硬化・循環器疾患の発症に及ぼす影響に関する疫学研究

    • Principal Investigator
      嶋本 喬
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Public health/Health science
    • Research Institution
      University of Tsukuba

  •  環境物質であるキノン系化合物の曝露による生体内NOの産生低下と循環器疾患の誘発Principal Investigator

    • Principal Investigator
      熊谷 嘉人
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Environmental pharmacy
    • Research Institution
      University of Tsukuba

  •  Therapy for Advanced Atherosclerosis by Using Vascular Endocrinological System

    • Principal Investigator
      HAYASHI Toshio
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Nagoya University

  •  Role of nitric oxide synthase in mercury toxicityPrincipal Investigator

    • Principal Investigator
      KUMAGAI Yoshito
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hygiene
    • Research Institution
      University of Tsukuba

  •  デイ-ゼル排出粒子によって誘発される喘息様症状におけるフラビン酵素の役割Principal Investigator

    • Principal Investigator
      熊谷 嘉人
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Biological pharmacy
    • Research Institution
      National Institute for Environmental Studies

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 Other

All Journal Article Presentation Book

  • [Book] 酸化ストレスの医学 改訂第2版2014
    • Author(s)
      熊谷嘉人.
    • Total Pages
      456
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Book] 毒性の科学2014
    • Author(s)
      熊谷嘉人
    • Total Pages
      216
    • Publisher
      東京大学出版会
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Book] 改定版分子予防環境医学2010
    • Author(s)
      熊谷嘉人
    • Publisher
      本の泉社.
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Book] 改定版分子予防環境医学2010
    • Author(s)
      熊谷嘉人
    • Publisher
      本の泉社
    • Data Source
      KAKENHI-PUBLICLY-21117504

  • [Book] 改定版分子予防環境医学2010
    • Author(s)
      熊谷嘉人
    • Publisher
      本の泉社
    • Data Source
      KAKENHI-PROJECT-22406004

  • [Book] 改定版分子予防環境医学2010
    • Author(s)
      熊谷嘉人
    • Publisher
      本の泉社
    • Data Source
      KAKENHI-PROJECT-21659154

  • [Book] 改定版分子予防環境医学2010
    • Author(s)
      熊谷嘉人
    • Publisher
      本の泉社
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Book] 実験医学増刊号.親電子シグナル伝達2009
    • Author(s)
      熊谷嘉人
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PUBLICLY-21117504

  • [Book] 活性酸素シグナルと酸化ストレス(実験医学増刊号)2009
    • Author(s)
      熊谷嘉人
    • Publisher
      羊土社.
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Establishment of a Novel Therapeutic Strategy for Heart Failure Based on the Mechanism Underlying Maintenance of Redox Homeostasis by Reactive Sulfur Species2018
    • Author(s)
      西田基宏、外山喬士、熊谷嘉人、富田拓郎.
    • Journal Title

      薬学雑誌

      Volume: 134 Issue: 12 Pages: 1239-1243

    • DOI
      10.1248/yakushi.14-00209-1
    • NAID
      130004712987
    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2018-08-31
    • Language
      Japanese
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Journal Article] Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics.2017
    • Author(s)
      Akaike Takaaki、、、Nishida Motohiro（4）、、、、、、Fujii Shigemoto（20）、、、Motohashi Hozumi（26）
    • Journal Title

      Nature Commun

      Volume: 8 Pages: 1177-1177

    • DOI
      10.1038/s41467-017-01311-y
    • NAID
      120006365562
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16KT0013, KAKENHI-PROJECT-16K09398, KAKENHI-PROJECT-17K07187, KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-17K19205, KAKENHI-PROJECT-17K19508, KAKENHI-PROJECT-17K19620, KAKENHI-PROJECT-17K15408, KAKENHI-PROJECT-17K15464, KAKENHI-PROJECT-17K17583, KAKENHI-INTERNATIONAL-15K21759, KAKENHI-PLANNED-26110003, KAKENHI-ORGANIZER-26111001, KAKENHI-PLANNED-26111008, KAKENHI-PLANNED-26111011, KAKENHI-PROJECT-17H06170, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15H03115, KAKENHI-PROJECT-15H04335, KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-16H04674, KAKENHI-PROJECT-17F17116, KAKENHI-PROJECT-15K08178, KAKENHI-PROJECT-15K08456, KAKENHI-PROJECT-16K13089, KAKENHI-PROJECT-16K15208, KAKENHI-PROJECT-15K20855, KAKENHI-PROJECT-15K20857, KAKENHI-PROJECT-15K20876

  • [Journal Article] The Capture of Cadmium by Reactive Polysulfides Attenuates Cadmium-Induced Adaptive Responses and Hepatotoxicity2017
    • Author(s)
      Akiyama Masahiro、Shinkai Yasuhiro、Unoki Takamitsu、Shim Ilseob、Ishii Isao、Kumagai Yoshito
    • Journal Title

      Chemical Research in Toxicology

      Volume: 30 Pages: 2209-2217

    • DOI
      10.1021/acs.chemrestox.7b00278
    • NAID
    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15K08042, KAKENHI-PROJECT-16K15194, KAKENHI-PROJECT-16K18920

  • [Journal Article] Cadmium-mediated activation of the HSP90/HSF1 pathway regulated by reactive persulfides/polysulfides2017
    • Author(s)
      Shinaki Y,Masuda A, Akiyama M, Xian M, Kumagai Y.
    • Journal Title

      Toxicol Sci

      Volume: 156 Pages: 412-421

    • DOI
      10.1093/toxsci/kfw268
    • NAID
    • Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15K08042

  • [Journal Article] TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice.2017
    • Author(s)
      Oda Sayaka、Numaga-Tomita Takuro、Kitajima Naoyuki、Toyama Takashi、Harada Eri、Shimauchi Tsukasa、Nishimura Akiyuki、Ishikawa Tatsuya、Kumagai Yoshito、Birnbaumer Lutz、Nishida Motohiro
    • Journal Title

      Sci Rep

      Volume: 7 Pages: 7511-7511

    • DOI
      10.1038/s41598-017-07903-4
    • NAID
      120006343876
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16KT0013, KAKENHI-PROJECT-17K15464, KAKENHI-PROJECT-17K15488, KAKENHI-PROJECT-17K15585, KAKENHI-PUBLICLY-16H01656, KAKENHI-PLANNED-26111011, KAKENHI-PROJECT-25220103

  • [Journal Article] Polysulfide Na2S4 regulates the activation of PTEN/Akt/CREB signaling and cytotoxicity mediated by 1,4-naphthoquinone through formation of sulfur adducts2017
    • Author(s)
      Abiko Yumi、Shinkai Yasuhiro、Unoki Takamitsu、Hirose Reiko、Uehara Takashi、Kumagai Yoshito
    • Journal Title

      Scientific Reports

      Volume: 7 Pages: 4814-4814

    • DOI
      10.1038/s41598-017-04590-z
    • NAID
      120006329286
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K15489, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15K08042, KAKENHI-PROJECT-16K18920

  • [Journal Article] Exposure to Electrophiles Impairs Reactive Persulfide-dependent Redox Signaling in Neuronal Cells2017
    • Author(s)
      Ihara Hideshi、Kasamatsu Shingo、Kitamura Atsushi、Nishimura Akira、Tsutsuki Hiroyasu、Ida Tomoaki、Ishizaki Kento、Toyama Takashi、Yoshida Eiko、Abdul Hamid Hisyam、Jung Minkyung、Matsunaga Tetsuro、Fujii Shigemoto、Sawa Tomohiro、Nishida Motohiro、Kumagai Yoshito、Akaike Takaaki
    • Journal Title

      Chemical Research Toxicology

      Volume: 30 Pages: 1673-1684

    • DOI
      10.1021/acs.chemrestox.7b00120
    • NAID
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16KT0013, KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-17K19205, KAKENHI-PROJECT-17K15408, KAKENHI-PROJECT-17K15488, KAKENHI-PROJECT-17K17583, KAKENHI-PLANNED-26111008, KAKENHI-PLANNED-26111011, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15H03115, KAKENHI-PROJECT-16H04674, KAKENHI-PROJECT-15K08456, KAKENHI-PROJECT-16K13089, KAKENHI-PROJECT-16K15208, KAKENHI-PROJECT-15K20855, KAKENHI-PROJECT-15K20857, KAKENHI-PROJECT-15K20876

  • [Journal Article] Environmental Electrophiles: Protein Adducts, Modulation of Redox Signaling, and Interaction with Persulfides/Polysulfides2017
    • Author(s)
      Kumagai Y, Abiko Y.
    • Journal Title

      Chemical Research in Toxicology.

      Volume: 30 Pages: 203-219

    • DOI
      10.1021/acs.chemrestox.6b00326
    • NAID
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-15H01392, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15K18906, KAKENHI-PROJECT-17K15489

  • [Journal Article] 環境中親電子物質のレドックスシグナル伝達変動および毒性発現とそれらを制御する活性イオウ分子2017
    • Author(s)
      熊谷嘉人、安孫子ユミ
    • Journal Title

      硫酸と工業

      Volume: 70 Pages: 9-16

    • NAID
      40021306408
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Journal Article] 1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation of HSP90 in A431 cells: Negative regulation of the redox signal transduction pathway by persulfides/polysulfides2017
    • Author(s)
      Abiko Y, Sha L, Shinkai Y, Unoki T, Luong NC, Tsuchiya Y, Watanabe Y, Hirose R, Akaike T, Kumagai Y.
    • Journal Title

      Free Radical Biology & Medicine

      Volume: 104 Pages: 118-128

    • DOI
      10.1016/j.freeradbiomed.2016.12.047
    • NAID
    • Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15K18994, KAKENHI-PROJECT-16K15208, KAKENHI-PROJECT-16K18920, KAKENHI-PROJECT-17K15489, KAKENHI-PROJECT-15K08042

  • [Journal Article] Modulation of Unfolded Protein Response by Methylmercury2017
    • Author(s)
      Hiraoka H, Nakahara K, Kaneko Y, Akiyama S, Okuda K, Iwawaki T, Fujimura M, Kumagai Y, Takasugi N, Uehara T.
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 40 Issue: 9 Pages: 1595-1598

    • DOI
      10.1248/bpb.b17-00359
    • NAID
      130006038778
    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed / Int'l Joint Research / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08272, KAKENHI-PROJECT-25220103

  • [Journal Article] Critical contribution of nuclear factor erythroid 2-related factor 2 (NRF2) to electrophile-induced interleukin-11 production2017
    • Author(s)
      Nishina T, Deguchi Y, Miura R, Yamazaki S, Shinkai Y, Kojima Y, Okumura K, Kumagai Y, Nakano H.
    • Journal Title

      J. Biol. Chem.

      Volume: 292 Pages: 205-216

    • DOI
      10.1074/jbc.m116.744755
    • NAID
      120006023247
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-15H01392, KAKENHI-PLANNED-26110003, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-26460397, KAKENHI-PROJECT-16K01378, KAKENHI-PROJECT-16K08747, KAKENHI-PROJECT-16K15681

  • [Journal Article] Methylmercury promotes prostacyclin release from cultured human brain microvascular endothelial cells via induction of cyclooxygenase-2 through activation of the EGFR-p38 MAPK pathway by inhibiting protein tyrosine phosphatase 1B activity2017
    • Author(s)
      Yoshida Eiko、Kurita Masaru、Eto Komyo、Kumagai Yoshito、Kaji Toshiyuki
    • Journal Title

      Toxicology

      Volume: 392 Pages: 40-46

    • DOI
      10.1016/j.tox.2017.09.013
    • NAID
      120006399226
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Journal Article] 環境中親電子物質に対する生体応答と捕獲・不活性化因子2017
    • Author(s)
      熊谷嘉人
    • Journal Title

      最新医学「エピジェネティックスと環境科学」

      Volume: 72 Pages: 77-81

    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Journal Article] Regulation of redox signaling by nitrated nucleotide and reactive cysteine persulfides. Nitric Oxide: Biology and Pathobiology.2017
    • Author(s)
      Sawa T, Kumagai Y, Akaike T.
    • Journal Title

      Nitric Oxide: Biology and Pathobiology

      Volume: 3 Pages: 231-235

    • DOI
      10.1016/b978-0-12-804273-1.00017-x
    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Journal Article] Heparan sulfate chains potentiate cadmium cytotoxicity in cultured vascular endothelial cells2016
    • Author(s)
      Fujiwara Y, Yamamoto C, Yoshida A, Kumagai Y, Kaji T.
    • Journal Title

      Archives of Toxicology

      Volume: 印刷中 Pages: 259-267

    • DOI
      10.1007/s00204-014-1420-6
    • NAID
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-24390034

  • [Journal Article] The chemical biology of protein hydropersulfides: Studies of a possible protective function of biological hydropersulfide generation.2016
    • Author(s)
      Millikin R, Bianco CL, White C, Saund SS, Henriquez S, Sosa V, Akaike T, Kumagai Y, Soeda S, Toscano JP, Lin J, Fukuto JM.
    • Journal Title

      Free Radic Biol Med.

      Volume: 97 Pages: 136-147

    • DOI
      10.1016/j.freeradbiomed.2016.05.013
    • NAID
    • Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01392, KAKENHI-ORGANIZER-26111001, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-16K15208, KAKENHI-INTERNATIONAL-15K21759

  • [Journal Article] Quinone-mediated induction of cytochrome P450 1A1 in HepG2 cells through increased interaction of aryl hydrocarbon receptor with aryl hydrocarbon receptor nuclear translocator2016
    • Author(s)
      Abiko Y, Lin FY, Lee H, Puga A, Kumagai Y.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 41 Issue: 6 Pages: 775-781

    • DOI
      10.2131/jts.41.775
    • NAID
      130005281972
    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed / Int'l Joint Research / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15K18906

  • [Journal Article] Redox signaling regulated by electrophiles and reactive sulfur species2016
    • Author(s)
      Nishida M, Kumagai Y, Ihara H, Fujii S, Motohashi H, Akaike T.
    • Journal Title

      J. Clin. Biochem. Nutr.

      Volume: 58 Issue: 2 Pages: 1-8

    • DOI
      10.3164/jcbn.15-111
    • NAID
      130005132519
    • ISSN
      0912-0009, 1880-5086
    • Language
      English
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K08456, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25430069, KAKENHI-PROJECT-26670207, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-25253020, KAKENHI-PLANNED-26111011, KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-16H05092, KAKENHI-PROJECT-15K14959, KAKENHI-PROJECT-16K15228, KAKENHI-PROJECT-16KT0013

  • [Journal Article] Chemical toxicology of reactive species in the atmosphere: two decades of progress in an electron acceptor and an electrophile2016
    • Author(s)
      Kumagai Y, Abiko Y, Luong CN.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 41 Issue: Special Pages: SP37-SP47

    • DOI
      10.2131/jts.41.SP37
    • NAID
      130005251461
    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-15H01392, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15K18906

  • [Journal Article] Partial contribution of the Keap1-Nrf2 system to cadmium-mediated metallothionein expression in vascular endothelial cells2016
    • Author(s)
      Shinkai Y, Kimura T, Itagaki A, Yamamoto C, Taguchi K, Yamamoto M, Kumagai Y, Kaji T.
    • Journal Title

      Toxicology and Applied Pharmacology.

      Volume: 295 Pages: 37-46

    • DOI
      10.1016/j.taap.2016.01.020
    • NAID
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460384, KAKENHI-PROJECT-15K14992, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-24390034, KAKENHI-PUBLICLY-16H01190, KAKENHI-PROJECT-15KK0325

  • [Journal Article] Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells.2016
    • Author(s)
      Unoki T, Abiko Y, Toyama T, Uehara T, Tsuboi K, Nishida M, Kaji T, Kumagai Y.
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 1-10

    • DOI
      10.1038/srep28944
    • NAID
      120005822867
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-26111011, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-16H05092, KAKENHI-PROJECT-16H05387, KAKENHI-PROJECT-15K14952, KAKENHI-PROJECT-15K14959, KAKENHI-PROJECT-16KT0013, KAKENHI-PROJECT-16K15573, KAKENHI-PROJECT-16K18920, KAKENHI-PROJECT-15H04649

  • [Journal Article] The Chemical Biology of Hydropersulfides (RSSH): Chemical Stability, Reactivity and Redox Roles.2015
    • Author(s)
      Saund SS, Sosa V, Henriquez, Nguyen QNN, Soeda S, Bianco CL, Millikin R, White C, Le H, Ono K, Tantillo DJ, Kumagai Y, Akaike T, Lin J, Fukuto JM.
    • Journal Title

      Archives Biochemistry and Biophysics.

      Volume: 588 Pages: 15-24

    • NAID
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01392, KAKENHI-PROJECT-25220103

  • [Journal Article] <i>S</i>-Mercuration of ubiquitin carboxyl-terminal hydrolase L1 through Cys152 by methylmercury causes inhibition of its catalytic activity and reduction of monoubiquitin levels in SH-SY5Y cells2015
    • Author(s)
      Toyama T, Abiko Y, Katayama Y, Kaji T, Kumagai Y.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 40 Issue: 6 Pages: 887-893

    • DOI
      10.2131/jts.40.887
    • NAID
      120006551789
    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Journal Article] Covalent binding of quinones activates the Ah receptor in Hepa1c1c7 cells2015
    • Author(s)
      Abiko Y, Puga A, Kumagai Y.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 40 Issue: 6 Pages: 873-886

    • DOI
      10.2131/jts.40.873
    • NAID
      130005108871
    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed / Int'l Joint Research / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K18906, KAKENHI-PROJECT-25220103

  • [Journal Article] Correlation between attenuation of protein disulfide isomerase activity through S-Mercuration and neurotoxicity induced by methyl mercury2015
    • Author(s)
      Makino K, Okuda K, Sugino E, Nishiya T, Toyama T, Iwawaki T, Fujimura M, Kumagai Y, Uehara T.
    • Journal Title

      Neurotoxicity Research

      Volume: 27 Pages: 99-105

    • DOI
      10.1007/s12640-014-9494-8
    • NAID
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-12J03394, KAKENHI-PROJECT-24390049, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25670029, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-26460068

  • [Journal Article] Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions2015
    • Author(s)
      Nakano S, Ishii I, Shinmura K, Tamaki K, Hishiki T, Akahoshi N, Ida T, Nakanishi T, Kamata S, Kumagai Y, Akaike T, Fukuda K, Sano M, Suematsu M.
    • Journal Title

      Journal of Molecular Medicine.

      Volume: 印刷中 Pages: 879-889

    • DOI
      10.1007/s00109-015-1271-5
    • NAID
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25460072, KAKENHI-PROJECT-25870549, KAKENHI-PROJECT-26460960, KAKENHI-PROJECT-15K20876, KAKENHI-PROJECT-15J03367, KAKENHI-PROJECT-26670207, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-25253020

  • [Journal Article] Hemizygosity of transsulfuration genes confers increased vulnerability against acetaminophen-induced hepatotoxicity in mice.2015
    • Author(s)
      Hagiya Y, Kamata S, Mitsuoka S, Okada N, Yoshida S, Yamamoto J, Ohkubo R, Abiko Y, Yamada H, Akahoshi N, Kasahara T, Kumagai Y, Ishii I.
    • Journal Title

      Toxicol Appl Pharmacol

      Volume: 282 Pages: 195-206

    • DOI
      10.1016/j.taap.2014.11.015
    • NAID
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25460072

  • [Journal Article] A Biotin-PEAC<sub>5</sub>-maleimide labeling assay to detect electrophiles2015
    • Author(s)
      Abiko Y, Luong NC, Kumagai Y.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 40 Issue: 3 Pages: 405-411

    • DOI
      10.2131/jts.40.405
    • NAID
      130005068421
    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K18906, KAKENHI-PROJECT-25220103

  • [Journal Article] Formation of sulfur adducts of N-acetyl-p-benzoquinoneimine, an electrophilic metabolite of acetaminophen in vivo: participation of reactive persulfides.2015
    • Author(s)
      Abiko Y., Ishii I., Kamata S., Tsuchiya Y., Watanabe Y., Ihara H., Akaike T., Kumagai Y.
    • Journal Title

      Chem Res Toxicol

      Volume: 28 Pages: 1796-1802

    • DOI
      10.1021/acs.chemrestox.5b00245
    • NAID
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K18994, KAKENHI-PUBLICLY-15H01392, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15J03367, KAKENHI-PROJECT-25430069, KAKENHI-PROJECT-25460072, KAKENHI-PROJECT-26670207, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-25253020

  • [Journal Article] RSSによる環境中親電子物質の解毒代謝.2015
    • Author(s)
      熊谷嘉人、内田浩二.
    • Journal Title

      細胞工学

      Volume: 34 Pages: 358-363

    • NAID
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Journal Article] Reactive Sulfur Species-Mediated Activation of the Keap1-Nrf2 Pathway by 1,2-Naphthoquinone through Sulfenic Acids Formation under Oxidative Stress.2015
    • Author(s)
      Shinkai Y, Abiko Y, Ida T, Miura T, Kakehashi H, Ishii I, Nishida M, Sawa T, Akaike T, Kumagai Y.
    • Journal Title

      Chemical Research in Toxicology

      Volume: 印刷中 Pages: 838-847

    • DOI
      10.1021/tx500416y
    • NAID
      130005483607
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25460072, KAKENHI-PROJECT-25870549, KAKENHI-PROJECT-15K14959, KAKENHI-PROJECT-15K20876, KAKENHI-PUBLICLY-15H01392, KAKENHI-PROJECT-15H03115, KAKENHI-PROJECT-26670131, KAKENHI-PROJECT-26670207, KAKENHI-PROJECT-25293018, KAKENHI-PLANNED-26111008, KAKENHI-PLANNED-26111011, KAKENHI-PROJECT-25253020

  • [Journal Article] Involvement of reactive persulfides in biological bismethylmercury sulfide formation2015
    • Author(s)
      Abiko Y, Yoshida E, Ishii I, Fukuto JM, Akaike T, Kumagai Y.
    • Journal Title

      Chem Res Toxicol

      Volume: 28 Pages: 1301-1306

    • DOI
      10.1021/acs.chemrestox.5b00101
    • NAID
    • Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01392, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25460072, KAKENHI-PROJECT-26670207, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-25253020

  • [Journal Article] レドックスサイクルを介して酸化ストレスを生じる大気中成分.2015
    • Author(s)
      熊谷嘉人、安孫子ユミ.
    • Journal Title

      「医学のあゆみ」レドックスUPDATE

      Volume: 別冊 Pages: 312-317

    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-15H01392

  • [Journal Article] Protective effects of hydrogen sulfide anions against acetaminophen-induced hepatotoxicity in mice2015
    • Author(s)
      Ishii I, Kamata S, Hagiya Y, Abiko Y, Kasahara T, Kumagai Y.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 40 Issue: 6 Pages: 837-841

    • DOI
      10.2131/jts.40.837
    • NAID
      130005108870
    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15J03367, KAKENHI-PROJECT-25460072

  • [Journal Article] Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility2014
    • Author(s)
      Ono, K., Akaike T., Sawa, T., Kumagai, Y., Wink, D. A., Tantillo, D. J., Hobbs, A. J., Nagy, P., Xian, M., Lin, J., Fukuto, J.
    • Journal Title

      Free Radic Biol Med

      Volume: 77 Pages: 82-94

    • DOI
      10.1016/j.freeradbiomed.2014.09.007
    • NAID
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24390082, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25253020, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-26670131, KAKENHI-PROJECT-26670207

  • [Journal Article] Activation of the Keap1/Nrf2 pathway through covalent modification of the 2-alkenal group of aliphatic electrophiles in Coriandrum sativum L. Journal of agricultural and food chemistry.2014
    • Author(s)
      Abiko Y, Mizokawa M, Kumagai Y.
    • Journal Title

      J Agric Food Chem.

      Volume: 62 Pages: 10936-10944

    • DOI
      10.1021/jf5030592
    • NAID
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Journal Article] Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling2014
    • Author(s)
      Ida T, Sawa T, Ihara H, Tsucr iya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S. Matsunaga T, Yamamoto M, Ono K, Devarie-Baez N O, Xian M, Fukuto J M, Akaike T.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: (印刷中) Pages: 7606-7611

    • DOI
      10.1073/pnas.1321232111
    • NAID
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-11F01105, KAKENHI-ORGANIZER-20117001, KAKENHI-PLANNED-20117005, KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-24390082, KAKENHI-PROJECT-24590527, KAKENHI-PROJECT-24790263, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25253020, KAKENHI-PROJECT-25430069, KAKENHI-PROJECT-25870549, KAKENHI-ORGANIZER-26111001, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-26670131, KAKENHI-PROJECT-26670150, KAKENHI-PROJECT-26670207

  • [Journal Article] <i>S</i>-Mercuration of cellular proteins by methylmercury and its toxicological implications2014
    • Author(s)
      Kanda H, Shinkai Y, Kumagai Y.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 39 Issue: 5 Pages: 687-700

    • DOI
      10.2131/jts.39.687
    • NAID
      130004690955
    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Journal Article] Ambient vapor samples activate the Nrf2-ARE pathway in human bronchial epithelial BEAS-2B cells.2014
    • Author(s)
      Yasuhiro Shinkai, Syun Nakajima, Arantza Eiguren-Fernandez, Emma Di Stefano, Debra A. Schmitz, John R. Froines, Arthur K. Cho, Yoshito Kumagai
    • Journal Title

      Environ Toxicol.

      Volume: 29 Pages: 1292-1300

    • DOI
      10.1002/tox.21860
    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590159, KAKENHI-PROJECT-25220103

  • [Journal Article] Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function.2014
    • Author(s)
      Contu VR, Kotake Y, Toyama T, Okuda K, Miyara M, Sakamoto S, Samizo S, Sanoh S, Kumagai Y, Ohta S.
    • Journal Title

      Journal of Neurochemistry

      Volume: 130 Pages: 826-838

    • DOI
      10.1111/jnc.12762
    • NAID
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-12J03394, KAKENHI-PROJECT-24406004, KAKENHI-PROJECT-25220103

  • [Journal Article] Identification and quantification of in vivo metabolites of 9,10-phenanthrenequinone in human urine associated with producing reactive oxygen species.2014
    • Author(s)
      Asahi M, Kawai M, Toyama T, Kumagai Y, Chuesaard T, Tang N, Kameda T. Havakawa K and Toriba A
    • Journal Title

      Chem Res Toxicol.

      Volume: 27(1) Pages: 41-48

    • DOI
      10.1021/tx400338t
    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J03394, KAKENHI-PROJECT-24406001, KAKENHI-PROJECT-24590160, KAKENHI-PROJECT-25220103

  • [Journal Article] Glutathione adduct of methylmercury activates the Keap1-Nrf2 pathway in SH-SY5Y cells.2014
    • Author(s)
      Yoshida E, Abiko Y, Kumagai Y.
    • Journal Title

      Chem Res Toxicol.

      Volume: 27 Pages: 1780-1786

    • DOI
      10.1021/tx5002332
    • NAID
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Journal Article] たくさん繋がるS.2014
    • Author(s)
      澤智裕、熊谷嘉人、赤池孝章.
    • Journal Title

      実験医学増刊「驚愕の代謝システム」

      Volume: 32 Pages: 46-50

    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Journal Article] The role of the Keap1/Nrf2 pathway in the cellular response to methylmercury.2013
    • Author(s)
      Kumagai Y, Kanda H, Shinkai Y and Toyama T
    • Journal Title

      Oxid Med Cell Longev.

      Volume: (Online) Pages: 848279-848279

    • DOI
      10.1155/2013/848279
    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J03394, KAKENHI-PROJECT-25220103

  • [Journal Article] Interaction of 9,10-phenanthraquinone with dithiol causes oxidative modification of Cu,Zn-superoxide dismutase (SOD) through redox cycling2013
    • Author(s)
      Koizumi R, Taguchi K, Hisamori M, Kumagai Y.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 38 Issue: 3 Pages: 317-324

    • DOI
      10.2131/jts.38.317
    • NAID
      10031158897
    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22406004, KAKENHI-PROJECT-25220103

  • [Journal Article] Interaction of Keap1 Modified by 2-tert-Butyl-1,4- benzoquinone with GSH: Evidence for S-Transarylation.2013
    • Author(s)
      Yumi Abiko, Yoshito Kumagai
    • Journal Title

      Chem Res Toxicol.

      Volume: 26 Pages: 1080-1087

    • DOI
      10.1021/tx400085h
    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J01747, KAKENHI-PROJECT-25220103

  • [Journal Article] A convenient method to assess chemical modification of protein thiols by electrophilic metals2013
    • Author(s)
      Toyama T, Shinkai Y, Kaji T and Kumagai Y.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 38(3) Issue: 3 Pages: 477-484

    • DOI
      10.2131/jts.38.477
    • NAID
      10031158913
    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J03394, KAKENHI-PROJECT-25220103

  • [Journal Article] <i>Garcinia vilersiana</i> bark extract activates the Nrf2/HO-1 signaling pathway in RAW264.7 cells2013
    • Author(s)
      Yasuhiro Shinkai, Ichiro Yamanaka, Ho Huynh Thuy Duong, Nguyen Thi Quynh, Yasunori Kanaho, Yoshito Kumagai
    • Journal Title

      J. Toxicol. Sci.

      Volume: 38 Issue: 6 Pages: 875-878

    • DOI
      10.2131/jts.38.875
    • NAID
      130004447090
    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590159, KAKENHI-PROJECT-25220103

  • [Journal Article] Critical contribution of oxidative stress to TNFalpha-induced necroptosis downstream of RIPK1 activation.2013
    • Author(s)
      Shindo R, Kakehashi H, Okumura K, Kumagai Y, Nakano H.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 436 Pages: 212-216

    • DOI
      10.1016/j.bbrc.2013.05.075
    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390260, KAKENHI-PROJECT-24390100, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25670167

  • [Journal Article] Activation of EGFR/MEK/ERK/AP-1 signaling mediated by 1,2-naphthoquinone, an atmospheric electrophile, in human pulmonary A549 cells2013
    • Author(s)
      Chang B, Iwamoto N, Inaba T, Shinkai Y, Kumagai Y.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 38 Issue: 5 Pages: 793-797

    • DOI
      10.2131/jts.38.793
    • NAID
      10031191738
    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Journal Article] 酸化ストレスと親電子シグナル制御.2013
    • Author(s)
      熊谷嘉人
    • Journal Title

      医学のあゆみ

      Volume: 247 Pages: 787-793

    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Journal Article] The chemical biology of naphthoquinones and its environmental implications2012
    • Author(s)
      Kumagai Y
    • Journal Title

      Annual Review of Pharmacology and Toxicology

      Volume: 52 Pages: 221-247

    • DOI
      10.1146/annurev-pharmtox-010611-134517
    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20241015, KAKENHI-PROJECT-22406004, KAKENHI-PUBLICLY-23117703, KAKENHI-PROJECT-23659063

  • [Journal Article] Cho AK. The chemical biology of naphthoquinones and its environmentalimpl ications2012
    • Author(s)
      Kumagai Y, Shinkai Y, Miura T
    • Journal Title

      Annual Review of Pharmacology and Toxicology

      Volume: 52 Pages: 221-247

    • NAID
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] 環境中親電子リガンドの細胞内侵入とそれに伴うシグナル伝達の模倣および攪乱.2012
    • Author(s)
      熊谷嘉人
    • Journal Title

      実験医学「活性酸素・ガス状分子による恒常性制御と疾患」

      Volume: 30 Pages: 70-75

    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23117703

  • [Journal Article] Redox cycling of 1,2-naphthoquinone by thioredoxin1 through Cys32 and Cys35 causes inhibition of its catalytic activity and activation of ASK1/p38 signaling2012
    • Author(s)
      Shinkai Y, Iwamoto N, Miura T, Ishii T, Cho AK, Kumagai Y
    • Journal Title

      Chemical Research in Toxicology

      Volume: 25 Pages: 1222-1230

    • DOI
      10.1021/tx300069r
    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659063

  • [Journal Article] A method for detecting covalent modification of sensor proteins associated with 1,4-naphthoquinone-induced activation of electrophilic signal transduction pathways2012
    • Author(s)
      Hirose R, Miura T, Sha R, Shinkai Y, Tanaka-Kagawa T, Kumagai Y.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 37 Issue: 5 Pages: 891-898

    • DOI
      10.2131/jts.37.891
    • NAID
      130004447003
    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22406004, KAKENHI-PROJECT-24590159

  • [Journal Article] Two-electron quinone reductase (AKR1C isozyme) augments the oxidative DNA damage induced by quinones in diesel exhaust particles by accelerating redox cycling2011
    • Author(s)
      Yamano S, Shibata M, Kita H, Matsusue K, Narimatsu S, Taguchi K, Kumagai Y
    • Journal Title

      Journal of Health Science

      Volume: 57 Pages: 107-114

    • NAID
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Peroxiredoxin 6 is a molecular target for 1,2-naphthoquinone, an atmospheric electrophile, in human pulmonary epithelial A549 cells2011
    • Author(s)
      Takayama N
    • Journal Title

      J. Toxicol. Sci.

      Volume: 36 Issue: 6 Pages: 817-821

    • DOI
      10.2131/jts.36.817
    • NAID
      10030037072
    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20241015, KAKENHI-PROJECT-22406004, KAKENHI-PROJECT-22790128

  • [Journal Article] Glyceraldehyde-3-phosphate dehydrogenase as a quinone reductase in the suppression of 1, 2-naphthoquinone protein adduct formation2011
    • Author(s)
      Miura T, Shinkai Y, Hirose R, Iwamoto N, Cho AK, Kumagai Y
    • Journal Title

      Free Radical Biology & Medicine

      Volume: 51 Pages: 2082-2089

    • NAID
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury.2011
    • Author(s)
      Toyama T, Shinkai Y, Yasutake A, Uchida K, Yamamoto M, Kumagai Y.
    • Journal Title

      Envornmental Health Perspective in press

    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] DNA microarray analysis of human neuroblastoma SH-SY5Y cells exposed to methylmercury2011
    • Author(s)
      Toyama T, Yoshida E, Shinkai Y, Kumagai Y
    • Journal Title

      Journal of Toxicological Sciences

      Volume: 36 Pages: 843-845

    • NAID
      10030037141
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury2011
    • Author(s)
      Toyama T, Shinkai Y, Yasutake A, Uchida K, Yamamoto M, Kumagai Y
    • Journal Title

      Environmental Health Perspective

      Volume: 119 Pages: 1117-1122

    • NAID
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] GSH-mediated S-transarylation of a quinone glyceraldehyde-3-phosphate dehydrogenase conjugate2011
    • Author(s)
      Miura T, Kakehashi H, Shinkai Y, Egara Y, Hirose R, Cho AK, Kumagai Y
    • Journal Title

      Chemical Research in Toxicology

      Volume: 24 Pages: 1836-1844

    • NAID
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Initial response and cellular protection through the Keapl/Nrf2 system during exposure of primary mouse hepatocytes to 1,2-naphthoquinone.2011
    • Author(s)
      Miura T, Shinkai Y, Jiang HY, Iwamoto N, Sumi D, Taguchi K, Yamamoto M, Jinno H, Tanaka-Kagawa T, Cho AK, Kumagai Y.
    • Journal Title

      Chemical Research in Toxicology in press

    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Participation of covalent modification f Keap1 in the activation of Nrf2 by tert-ylbenzoquinone, an electrophilic metabolite of butylated hydroxyanisole2011
    • Author(s)
      Abiko Y, Miura T, Bui H Phuc, Shinkai Y, Kumagai Y
    • Journal Title

      Toxicology and Applied Pharmacology

      Volume: 255 Pages: 32-39

    • NAID
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Peroxiredoxin 6 is a molecular target for 1, 2-naphthoquinone, an atmospheric electrophile, in human pulmonary epithelial A549 cells2011
    • Author(s)
      Takayama N, Iwamoto N, Sumi D, Shinkai Y, Tanaka-Kagawa T, Jinno H, Kumagai Y
    • Journal Title

      Journal of Toxicological Sciences

      Volume: 36 Pages: 817-821

    • NAID
      10030037072
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Initial response and cellular protection through the Keap1/Nrf2 system during exposure of primary mouse hepatocytes to 1, 2-naphthoquinone2011
    • Author(s)
      Miura T, Shinkai Y, Jiang HY, Iwamoto N, Sumi D, Taguchi K, Yamamoto M, Jinno H, Tanaka-Kagawa T, Cho AK, Kumagai Y
    • Journal Title

      Chemical Research in Toxicology

      Volume: 24 Pages: 559-567

    • NAID
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Initial response and cellular protection through the Keap1/Nrf2 system during exposure of primary mouse hepatocytes to 1,2-naphthoquinone2011
    • Author(s)
      Miura T, Shinkai Y, Jiang HY, Iwamoto N, Sumi D, Taguchi K, Yamamoto M, Jinno H, Tanaka-Kagawa T, Cho AK, Kumagai Y
    • Journal Title

      Chem.Res.Toxicol.

      Volume: 24 Pages: 559-567

    • DOI
      10.1021/tx100427p
    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-22406004, KAKENHI-PROJECT-22790127, KAKENHI-PUBLICLY-23117503

  • [Journal Article] Participation of covalent modification of Keap1 in the activation of Nrf2 by tert-butylbenzoquinone, an electrophilic metabolite of butylated hydroxyanisole2011
    • Author(s)
      Endo A, Sumi D, Iwamoto N, Kumagai Y
    • Journal Title

      Toxicology and Applied Pharmacology

      Volume: 255 Pages: 32-39

    • NAID
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Diesel exhaust particles induce a Th2 phenotype in mouse naive mononuclear cells in vitro2010
    • Author(s)
      Inoue K, Koike E, Endo A, Sumi D, Kumagai Y, Hayakawa K, Kiyono M, Tanaka M, Takano H
    • Journal Title

      Experimental and Therapeutic Medicine

      Volume: 1 Pages: 761-767

    • NAID
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Biochemical and cellular effects of electrophiles present in ambient air samples2010
    • Author(s)
      Iwamoto N, Nishiyama A, Eiguren-Fernandez A, Hinds W, Kumagai Y, Froines JR, Cho AK, Shinyashiki M
    • Journal Title

      Atmospheric Environment

      Volume: 44 Pages: 1483-1489

    • DOI
      10.1016/j.atmosenv.2010.01.045
    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22406004

  • [Journal Article] 1, 2-Naphthoquinone suppresses lipopolysaccharidedependentactivation of IKKss/NF-kB/NO signaling : an alternative mechanism for the disturbance of inducible NO synthase-catalyzed NO formation2010
    • Author(s)
      Sumi D, Akimori M, Inoue K, Takano H, Kumagai Y
    • Journal Title

      Journal of Toxicological Sciences

      Volume: 35 Pages: 891-898

    • NAID
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Polycyclic aromatic hydrocarbon quinones as redox and electrophilic the micals contaminated in the atmosphere2010
    • Author(s)
      Kumagai Y
    • Journal Title

      Journal of Health Sciences 55

      Pages: 887-894

    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-21117504

  • [Journal Article] Polycyclic aromatic hydrocarbon quinones as redox and electrophilic chemicals contaminated in the atmosphere2010
    • Author(s)
      Kumagai Y
    • Journal Title

      Journal of Health Sciences 55

      Pages: 887-894

    • NAID
      130000127984
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659154

  • [Journal Article] Diesel exhaust particles induce a Th2 phenotype in mouse naive mononuclear cells in vitro2010
    • Author(s)
      Inoue K, Koike E, Endo A, Sumi D, Kumagai Y, Hayakawa K, Kiyono M, Tanaka M, Takano H.
    • Journal Title

      Experimental and Therapeutic Medicine

      Volume: 1 Pages: 761-767

    • DOI
      10.3892/etm.2010.129
    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22406004

  • [Journal Article] Reduction of arsenic-induced cytotoxicity through Nrf2/HO-1 signaling in HepG2 cells.2010
    • Author(s)
      Abiko Y, Shinkai Y, Sumi D, Kumagai Y.
    • Journal Title

      Journal of Toxicological Sciences 35

      Pages: 419-423

    • NAID
      10026469935
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Redox and electrophilic properties ofvapor- and particle-phase components of ambient aerosols2010
    • Author(s)
      Eiguren-Fernandez A, Shinyashiki M, Schmitz DA, Distefano E, Hinds W, Kumagai Y, Cho AK, Froines JR
    • Journal Title

      Environmental Research

      Volume: 110 Pages: 207-212

    • DOI
      10.1016/j.envres.2010.01.009
    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22406004

  • [Journal Article] Involvement of sensory nerves and TRPV1 receptors in the rat airway inflammatory response to two environment pollutants: diesel exhaust particles (DEP) and 1,2-naphthoquinone (1,2-NQ)2010
    • Author(s)
      Teles AM, Kumagai Y, Brain SD, Teixeira SA, Varriano AA, Barreto MA, de Lima WT, Antunes E, Muscara MN, Costa SK.
    • Journal Title

      Archives of Toxicology

      Volume: 84 Pages: 109-117

    • DOI
      10.1007/s00204-009-0427-x
    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22406004

  • [Journal Article] Involvement of sensory nerves and TRPV1 receptors in the rat airway inflammatory response to two environment pollutants : diesel exhaust particles (DEP) and 1, 2-naphthoquinone (1, 2-NQ)2010
    • Author(s)
      Teles AM, Kumagai Y, Brain SD, Teixeira SA, Varriano AA, Barreto MA, de Lima WT, Antunes E, Muscara MN, Costa SK
    • Journal Title

      Archives of Toxicology

      Volume: 84 Pages: 109-117

    • NAID
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Reduction of arsenic-induced cytotoxicity through Nrf2/HO-1 signaling in HepG2 cells2010
    • Author(s)
      Abiko Y, Shinkai Y, Sumi D, Kumagai Y
    • Journal Title

      Journal of Toxicological Sciences

      Volume: 35 Pages: 419-423

    • NAID
      10026469935
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Signal transduction pathways and transcription factors triggered by arsenic trioxide in leukemia cells2010
    • Author(s)
      Sumi D, Shinkai Y, Kumagai Y
    • Journal Title

      Toxicology and Applied Pharmacology

      Volume: 244 Pages: 385-392

    • NAID
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Immunochemical method to detect proteins that undergo selective modification by 1, 2-naphthoquinone derived from naphthalene through metabolic activation2010
    • Author(s)
      Miura T, Kumagai Y
    • Journal Title

      Journal of Toxicological Sciences

      Volume: 35 Pages: 843-852

    • NAID
      10026963043
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Carbon monoxide derived from heme oxygenase-2 mediates reduction of methylmercury toxicity in SH-SY5Y cells2010
    • Author(s)
      Toyama T, Shinkai Y, Sumi D, Kumagai Y
    • Journal Title

      Toxicology and Applied Pharmacology

      Volume: 249 Pages: 86-90

    • NAID
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range chemical compounds2009
    • Author(s)
      Kobayashi M, Li L, Iwamoto N, Nakajima-Takagi Y, Kaneko H, Nakayama Y, Eguchi M, Wada Y, Kumagai Y, Yamamoto M
    • Journal Title

      Molecular and Cellular Biology

      Volume: 29 Pages: 493-502

    • NAID
      120001086973
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Polycyclic aromatic hydrocarbon quinones as redox and electrophilic chemicals contaminated in the atmosphere2009
    • Author(s)
      Kumagai Y
    • Journal Title

      Journal of Health Sciences 55

      Pages: 887-894

    • NAID
      130000127984
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Polycyclic aromatic hydrocarbon quinones as redox and electrophilic chemicals contaminated in the atmosphere2009
    • Author(s)
      Kumagai Y
    • Journal Title

      Journal of Health Sciences

      Volume: 55 Pages: 887-894

    • NAID
      130000127984
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] 親電子シグナル伝達2009
    • Author(s)
      熊谷嘉人
    • Journal Title

      実験医学増刊号

      Volume: 27 Pages: 50-55

    • NAID
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article]2009
    • Author(s)
      熊谷嘉人
    • Journal Title

      実験医学増刊号.親電子シグナル伝達(羊土社)

      Pages: 50-55

    • Data Source
      KAKENHI-PROJECT-21659154

  • [Journal Article] Role of aquaporin 9 in cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes2009
    • Author(s)
      Shinkai Y, Sumi D, Toyama T, Kaji T, Kumagai Y
    • Journal Title

      Toxicology and Applied Pharmacology

      Volume: 237 Pages: 232-236

    • NAID
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap12009
    • Author(s)
      Sumi D, Numasawa Y, Endo A, Iwamoto N, Kumagai Y
    • Journal Title

      Journal of Toxicological Sciences

      Volume: 34 Pages: 627-635

    • NAID
      110007485673
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article]2009
    • Author(s)
      熊谷嘉人
    • Journal Title

      実験医学増刊号.親電子シグナル伝達(羊土社)

      Pages: 50-55

    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Redox cycling of 9,10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells2008
    • Author(s)
      Taguchi K, Shimada M, Fujii S,umi D, Pan XQ,Yamano S, Nishiyama T, Hiratsuka A, Yamamoto M, Cho AK, Froines JR, Kumagai Y
    • Journal Title

      Free Radical Biology & Medicine 2008 44

      Pages: 1945-1655

    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18406003

  • [Journal Article] Reduction of arginase I activity and manganese levels in the liver during exposure of rats to methylmercury : a possible mechanism.2008
    • Author(s)
      Kanda H, Sumi D, Endo E, Toyama T, Chen CL, Kikushima M, Kumagai Y.
    • Journal Title

      Archives of Toxicology. 82

      Pages: 803-808

    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Xylulose reductase is involved in 9, 10-phenanthrenequinone-induced apoptosis in human T lymphoma cells2008
    • Author(s)
      Matsunaga T, Kamiya T, Sumi D, Kumagai Y, B. Kalyanaraman, Hara A
    • Journal Title

      Free Radical Biology & Medicine

      Volume: 44 Pages: 1191-1202

    • NAID
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Downregulation of Arginase II and Renal Apoptosis by Inorganic Mercury : Overexpression of Arginase II Reduces Its Apoptosis2008
    • Author(s)
      Kanda H, Kikushima M, Homma-Takeda S, Sumi D, Endo A, Toyama T, Miura N, Naganuma A, Kumagai Y
    • Journal Title

      Archives of Toxicology

      Volume: 82 Pages: 67-73

    • NAID
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Redox cycling of 9, 10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells2008
    • Author(s)
      Taguchi K, Shimada M, Fujii S, Sumi D, 24. Taguchi K, Shimada M, Fujii S, Sumi D, Pan XQ, Yamano S, Nishiyama T, Hiratsuka A, Yamamoto M, Cho AK, Froines JR, Kumagai Y
    • Journal Title

      Free Radical Biology & Medicine

      Volume: 44 Pages: 1645-1655

    • NAID
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] On the interaction between glyceraldehyde-3-phosphate dehydrogenase and airborne particles2008
    • Author(s)
      Shinyashiki M, Rodriguez CE, Di Stefano EW, Sioutas C, Delfino RJ, Kumagai Y, Froines JR, Cho AK
    • Journal Title

      Evidence for electrophilic species 42

      Pages: 517-529

    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18406003

  • [Journal Article] Reduction of arginase I activity and manganese levels in the liver during exposure of rats to methylmercury : a possible mechanism2008
    • Author(s)
      Kanda H, Sumi D, Endo E, Toyama T, Chen CL, Kikushima M, Kumagai Y
    • Journal Title

      Archives of Toxicology

      Volume: 82 Pages: 803-808

    • NAID
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Redox cycling of 9,10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells.2008
    • Author(s)
      Taguchi K, Shimada M, Fujii S, Sumi D, Pan XQ, Yamano S, Nishiyama T, Hiratsuka A, Yamamoto M, Cho AK, Froines JR, Kumagai Y.
    • Journal Title

      Free Radical Biology & Medicine 44

      Pages: 1645-1655

    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Journal Article] Effects of naphthoquinone on airway responsiveness in the presence or absence of antigen in mice2007
    • Author(s)
      Inoue KI, Takano H, Ichinose T, Tomura S, Yanagisawa R, Sakurai M, Sumi D, Hiyoshi K, Kumagai Y
    • Journal Title

      Archives of Toxicology 2007 81

      Pages: 575-581

    • NAID
      120000834559
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18406003

  • [Journal Article] Arsenic: Signal Transduction, Transcription Factor, and Biotransformation Involved in Cellular Response and Toxicity2007
    • Author(s)
      Kumagai Y
    • Journal Title

      Annual Review of Pharmacology and Toxicology 47

      Pages: 243-262

    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18256005

  • [Journal Article] Naphthoquinone enhances antigen-related airway inflammation in mice.2007
    • Author(s)
      Inoue KI, Takano H, Hiyoshi K, Ichinose T, Sadakane K, Yanagisawa R, Tomura S, Kumagai Y.
    • Journal Title

      Eur Respir J. 29

      Pages: 259-267

    • NAID
    • Data Source
      KAKENHI-PROJECT-18406003

  • [Journal Article] Naphthoquinone enhances antigen-related airway inflammation in mice2007
    • Author(s)
      Inoue KI, Takano H, Hiyoshi K, Ichinose T, Sadakane K, Yanagisawa R, Tomura S, Kumagai Y
    • Journal Title

      European Respiratory Journal 2007 29

      Pages: 259-267

    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18406003

  • [Journal Article] An approach to evaluate two-electron reduction of 9,10-phenanthraquinone and redox activity of the hydroquinone associated with oxidative stress2007
    • Author(s)
      Taguchi K, Fujii S, Yamano S, Cho AK, Kamisuki S, Nakai Y, Sugawara F, Froines JR, Kumagai Y
    • Journal Title

      Free Radical Biology & Medicine 2007 43

      Pages: 789-799

    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18406003

  • [Journal Article] Arsenic : signal transduction, Transcription factor, and biotransformation involved in cellular response and toxicity2007
    • Author(s)
      Kumagai, Y
    • Journal Title

      Annual Review of Pharmacology and Toxicology 47

      Pages: 243-262

    • NAID
    • Data Source
      KAKENHI-PROJECT-18256005

  • [Journal Article] Chemical knockdown of protein tyrosine phosphatase 1B by 1, 2-naphthoquinone through covalent modification causes persistent transactivation of epidermal growth factor receptor2007
    • Author(s)
      Iwamoto N, Sumi D, Ishii T, Uchida K, Cho AK, Froines JR, Kumagai Y
    • Journal Title

      Journal of Biological Chemistry 2007 282

      Pages: 33396-33404

    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18406003

  • [Journal Article] Naphthoquinone enhances antigen-related airway inflammation in mice.2007
    • Author(s)
      Inoue KI, Takano H, Hiyoshi K, Ichinose T, Sadakane K, Yanagisawa R, Tomura S, Kumagai Y.
    • Journal Title

      Eur Respir J. 29

      Pages: 259-267

    • NAID
    • Data Source
      KAKENHI-PROJECT-18659167

  • [Journal Article] Arsenic : Signal Transduction, Transcription Factor, and Biotransformation Involved in Cellular Response and Toxicity.2007
    • Author(s)
      Kumagai Y, Sumi D.
    • Journal Title

      Annu Rev Pharmacol Toxicol. 47

      Pages: 243-262

    • NAID
    • Data Source
      KAKENHI-PROJECT-18659167

  • [Journal Article] Signal Transduction, Transcription Factor, and Biotransformation Involved in Cellular Response and Toxicity2007
    • Author(s)
      Kumagai Y, Sumi D. Arsenic
    • Journal Title

      Annual Review of Pharmacology and Toxicology 47

      Pages: 243-262

    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18256005

  • [Journal Article] Effects of naphthoquinone on airway responsiveness in the presence or absence of antigen in mice.2007
    • Author(s)
      Inoue KI, Takano H, Ichinose T, Tomura S, Yanagisawa R, Sakurai M, Sumi D, Hiyoshi K, Kumagai Y.
    • Journal Title

      Arch Toxicol. (In press)

    • NAID
      120000834559
    • Data Source
      KAKENHI-PROJECT-18659167

  • [Journal Article] Effects of naphthoquinone on airway responsiveness in the presence or absence of antigen in mice.2007
    • Author(s)
      Inoue KI, Takano H, Ichinose T, Tomura S, Yanagisawa R, Sakurai M, Sumi D, Hiyoshi K, Kumagai Y.
    • Journal Title

      Arch Toxicol. (In press)

    • NAID
      120000834559
    • Data Source
      KAKENHI-PROJECT-18406003

  • [Journal Article] Arsenic : Signal Transduction, Transcription Factor, and Biotransformation Involved in Cellular Response and Toxicity.2007
    • Author(s)
      Kumagai Y, Sumi D.
    • Journal Title

      Annu Rev Pharmacol Toxicol. 47

      Pages: 243-262

    • NAID
    • Data Source
      KAKENHI-PROJECT-18406003

  • [Journal Article] Signal transduction, transcription factor, and biotransformation involved in cellular response and toxicity2007
    • Author(s)
      Y. Kumagai, et. al.
    • Journal Title

      Annu. Rev. Pharm. 47

      Pages: 789-799

    • NAID
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19406003

  • [Journal Article] 1, 2-Naphthoquinone activates vanilloid receptor 1 through increased protein tyrosine phosphorylation, leading to contraction of guinea pig trachea.2006
    • Author(s)
      Kikuno S, Taguchi K, Iwamoto N, Yamano S, Cho AK, Froines JR, Kumagai Y.
    • Journal Title

      Toxicology and Applied Pharmacology. 210

      Pages: 47-54

    • NAID
    • Data Source
      KAKENHI-PROJECT-18659167

  • [Journal Article] 1,2-Naphthoquinone activates vanilloid receptor 1 through increased protein tyrosine phosphorylation, leading to contraction of guinea pig trachea.2006
    • Author(s)
      Kikuno S, Taguchi K, Iwamoto N, Yamano S, Cho AK, Froines JR, Kumagai Y
    • Journal Title

      Toxicology, and Applied Pharmacology 210

      Pages: 47-54

    • NAID
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390184

  • [Journal Article] Inhibition of Endothelial Nitric Oxide Synthase Activity and Suppression of Endothelium-Dependent Vasorelaxation by 1,2-Naphthoquinone, a Component of Diesel Exhaust Particles.2006
    • Author(s)
      Sun Y, Taguchi K, Sumi D, Yamano S, Kumagai Y.
    • Journal Title

      Arch Toxicol. 80

      Pages: 280-285

    • NAID
    • Data Source
      KAKENHI-PROJECT-18406003

  • [Journal Article] 1,2-Naphthoquinone activates vanilloid receptor 1 through increased protein tyrosine phosphorylation, leading to contraction of guinea pig trachea.2006
    • Author(s)
      Kikuno S, Taguchi K, Iwamoto N, Yamano S, Cho AK, Froines JR, Kumagai Y.
    • Journal Title

      Toxicology and Applied Pharmacology. 210

      Pages: 47-54

    • NAID
    • Data Source
      KAKENHI-PROJECT-18406003

  • [Journal Article] 1,2-Naphthoquinone activates vanilloid receptor 1 through increased protein tyrosine phosphorylation, leading to contraction of guinea pig trachea.2006
    • Author(s)
      Kikuno S, Taguchi K, Iwamoto N, Yamano S, Cho AK, Froines, JR, Kumagai Y
    • Journal Title

      Toxicology, and Applied Pharmacology 210

      Pages: 47-54

    • NAID
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390184

  • [Journal Article] Sulforphane, an activator of Nrf2,suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes.2006
    • Author(s)
      Shinkai Y, sumi D, Fukami I, Ishii T, Kumagai Y
    • Journal Title

      FEBS Letters (In press)

    • NAID
    • Data Source
      KAKENHI-PROJECT-15406004

  • [Journal Article] Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes.2006
    • Author(s)
      Shinkai Y, Sumi D, Fukami I, Ishii T, Kumagai Y.
    • Journal Title

      FEBS Letters. 580

      Pages: 1771-1774

    • NAID
    • Data Source
      KAKENHI-PROJECT-18659167

  • [Journal Article] Inhibition of Endothelial Nitric Oxide Synthase Activity and Suppression of Endothelium-Dependent Vasorelaxation by 1, 2-Naphthoquinone, a Component of Diesel Exhaust Particles.2006
    • Author(s)
      Sun Y, Taguchi K, Sumi D, Yamano S, Kumagai Y.
    • Journal Title

      Arch Toxicol. 80

      Pages: 280-285

    • NAID
    • Data Source
      KAKENHI-PROJECT-18659167

  • [Journal Article] Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes.2006
    • Author(s)
      Shinkai Y, Sumi D, Fukami I, Ishii T, Kumagai Y.
    • Journal Title

      FEBS Letters. 580

      Pages: 1771-1774

    • NAID
    • Data Source
      KAKENHI-PROJECT-18406003

  • [Journal Article] Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes.2006
    • Author(s)
      Shinkai Y, Sumi D, Fukami I, Ishii T, Kumagai Y
    • Journal Title

      FEBS Letters (In press)

    • NAID
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15406004

  • [Journal Article] Effects of single intratracheal administration of phenanthraquinone on murine lung.2005
    • Author(s)
      Hiyoshi K, Takano H, Inoue K, Ichinose T, Yanagisawa R, Tomura S, Cho AK, Froines JR, Kumagai Y
    • Journal Title

      Journal of Applied Toxicology 25

      Pages: 47-51

    • NAID
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390184

  • [Journal Article] 9,10-phenanthraquinone in diesel exhaust downregulates HO-1 and Cu, Zn-SOD in human pulmonary epithelial cells : intracellular iron scavenger 1,10-phenanthroline affords protection against apoptosis.2005
    • Author(s)
      Sugimoto R, Kumagai Y, Nakai Y, Ishii T
    • Journal Title

      Free Radical Biology & Medicine 38

      Pages: 388-397

    • NAID
    • Data Source
      KAKENHI-PROJECT-15390184

  • [Journal Article] Effects of phenanthraquinone on allergic airway inflammation in mice.2005
    • Author(s)
      Hiyoshi K, Takano H, Inoue K, Ichinose T, Yanagisawa R, Tomura S, Kumagai Y
    • Journal Title

      Clinical Experimental Allergy 35

      Pages: 1243-1248

    • NAID
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390184

  • [Journal Article] Effects of single intraracheal administration of phenanthraquinoes on murine lung.2005
    • Author(s)
      Hiyoshi K, Takano H, Inoue K, Ichinose T, Yanagisawa R, Tomura S, Cho AK, Froines JR, Kumagai Y
    • Journal Title

      Journal of Applied Toxicology 25

      Pages: 47-51

    • NAID
    • Data Source
      KAKENHI-PROJECT-15390184

  • [Journal Article] Vascular dysfunction in patients with chronic arsenosis can be reversed by reduction of arsenic exposure.2005
    • Author(s)
      Pi JB, Yamauchi H, Sun GF, Yoshida T, Aikawa H, Fujimoto W, Iso H, Cui RZ, Kumagai Y
    • Journal Title

      Environmental Health Perspective 113

      Pages: 339-341

    • NAID
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15406004

  • [Journal Article] Effects of single intratracheal administration of phenanthraquinone on murine lung.2005
    • Author(s)
      Hiyoshi K, Takano H, Inoue K, Ichinose T, Yanagisawa R, Tomura S, Cho AK, Froines, JR, Kumagai Y
    • Journal Title

      Journal of Applied Toxicology 25

      Pages: 47-51

    • NAID
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390184

  • [Journal Article] 9,10-phenanthraquinone in diesel exhaust downregulates HO-1 and Cu, Zn-SOD in human pulmonary epithelial cells : intracellular iron scavenger 1.10-phenanthroline affords protection against apoptosis.2005
    • Author(s)
      Sugimoto R, Kumagai Y, Nakai Y, Ishii T
    • Journal Title

      Free Radical Biology & Medicine 38

      Pages: 388-397

    • NAID
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390184

  • [Journal Article] 9,10-phenanthraquinone in diesel exhaust downregulates HO-1 and Cu,Zn-SOD in human pulmonary epithelial cells : intracellular iron scavenger 1.10-phenanthroline affords protection against apoptosis.2005
    • Author(s)
      Sugimoto R, Kumagai Y, Nakai Y, Ishii T
    • Journal Title

      Free Radical Biology & Medicine 38

      Pages: 388-397

    • NAID
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390184

  • [Journal Article] Monomethylarsonous acid inhibits endothelial nitric oxide activity.2005
    • Author(s)
      Sumi D, Taguchi K, Sun Y, Shinkai Y, Kumagai Y
    • Journal Title

      Journal of Health Sciences 52

      Pages: 728-730

    • NAID
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15406004

  • [Journal Article] Redox activity of airborne particulate matter at different sites in the Los Angeles Basin.2005
    • Author(s)
      Cho AK, Sioutas C, Miguel AH, Kumagai Y, Schmitz DA, Singh M, Eiguren-Fernandez A, Froines JR
    • Journal Title

      Environmental Research 99

      Pages: 40-47

    • NAID
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390184

  • [Journal Article] Redox activity of airborne particulate matter at different sites in the Los Angels Basin.2005
    • Author(s)
      Cho AK, Sioutas C, Miguel AH, Kumagai Y, Schmitz DA, Singh M, Eiguren-Fernandez A, Froines JR
    • Journal Title

      Environmental Research 99

      Pages: 40-47

    • NAID
    • Data Source
      KAKENHI-PROJECT-15390184

  • [Journal Article] Monomethylarsonous acid inhibits endothelial nitritic oxide activity.2005
    • Author(s)
      Sumi D, Taguchi K, Sun Y, Shinkai Y, Kumagai Y
    • Journal Title

      Journal of Health Sciences 52

      Pages: 728-730

    • NAID
    • Data Source
      KAKENHI-PROJECT-15406004

  • [Journal Article] Neuronal nitric oxide synthase (nNOS) catalyzes one-electron reduction of 2,4,6-trinitrotoluene, resulting in decreased nitric oxide production and increased nNOS gene expression : Implication for oxidative stress.2004
    • Author(s)
      Kumagai Y et al.
    • Journal Title

      Free Rad Biol Med 37

      Pages: 350-357

    • NAID
    • Data Source
      KAKENHI-PROJECT-15659141

  • [Journal Article] Determination of four quinones in diesel exhaust particles, SRM1649a and, atmospheric PM2.5.2004
    • Author(s)
      Cho AK, Schmitz DA, Ying Y, Rodriguez CE, DiStefano EW, Kumagai Y, Miguel A, Eiguren A, Kobayashi T, Avol E, Froines JR
    • Journal Title

      Aerosol Science and Technology 38

      Pages: 68-81

    • NAID
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390184

  • [Journal Article] Neuronal nitric oxide synthase (nNOS) catalyzes one-electron reduction of 2,4,6-trinitrotoluene, resulting in decreased nitric oxide production and increased nNOS gene expression : Implication for oxidative stress.2004
    • Author(s)
      Kumagai Y et al.
    • Journal Title

      Free Rad Biol Med 37

      Pages: 350-357

    • NAID
    • Data Source
      KAKENHI-PROJECT-15390184

  • [Journal Article] Neuronal nitric oxide synthase (nNOS) catalyzes one-electron reduction of 2,4,6-trinitrotoluene, resulting in decreased nitric oxide production and increased nNOS gene expression : Implication for oxidative stress.2004
    • Author(s)
      Kumagai Y et al.
    • Journal Title

      Free Rad Biol Med 37

      Pages: 350-357

    • NAID
    • Data Source
      KAKENHI-PROJECT-15406004

  • [Journal Article] Molecular basis for arsenic-mediated alteration in nitric oxide production and oxidative stress : implication of endothelial dysfunction.2004
    • Author(s)
      Kumagai Y, Pi JB.
    • Journal Title

      Toxicol Appl Pharmacol 198

      Pages: 450-457

    • NAID
    • Data Source
      KAKENHI-PROJECT-15406004

  • [Journal Article] Decreased enzyme activities of hepatic thioredoxin reductase and glutathione reductase in rabbits by prolonged exposure to inorganic arsenate.2003
    • Author(s)
      Nikaido M, Pi JB, Kumagai Y, Yamauchi H, Taguchi K, Horiguchi S, Sun Y, Sun GF, Shimojo N
    • Journal Title

      Environmental Toxicology 18

      Pages: 306-311

    • NAID
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15406004

  • [Journal Article] A potential mechanism for the impairment of nitric oxide formation caused by prolonged oral exposure to arsenate in rabbits.2003
    • Author(s)
      Pi JB, Horiguchi S, Sun Y, Nikaido M, Shimojo N, Hayashi T, Yamauchi H, Sun GF, Itoh K, Yamamoto M, Waalkes MP, Kumagai Y
    • Journal Title

      Free Radical Biology & Medicine 35

      Pages: 102-113

    • NAID
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15406004

  • [Journal Article] Molecular Basis for Arsenic-Mediated Alteration in Nitric Oxide Puroduction and Oxidative Stress : Implication of Endothelial Dysfunction2003
    • Author(s)
      Kumagai Y, Pi JB.
    • Journal Title

      Toxicology and Applied Pharmacology (in press)

    • NAID
    • Data Source
      KAKENHI-PROJECT-13576029

  • [Journal Article] Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes : involvement of hydrogen peroxide.2003
    • Author(s)
      Pi JB, Qu W, Reece J M, Kumagai Y
    • Journal Title

      Experimental Cell Research 290

      Pages: 234-245

    • NAID
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15406004

  • [Journal Article] ディーゼル排出微粒子と酸化ストレス防御蛋白質2002
    • Author(s)
      石井哲郎, 熊谷嘉人
    • Journal Title

      The Lung Perspective 10

      Pages: 64-69

    • NAID
    • Data Source
      KAKENHI-PROJECT-13672340

  • [Journal Article] Possible mechanisms for induction of oxidative stress and suppression of systemic nitric oxide production caused by exposure to exvironmental chemicals2002
    • Author(s)
      Kumagai Y, Shimojo N.
    • Journal Title

      Environmental Health and Preventive Mdicine 7

      Pages: 141-150

    • NAID
    • Data Source
      KAKENHI-PROJECT-13575036

  • [Journal Article] Possible mechanisms for induction of oxidative stress and suppression of systemic nitric oxide production caused by exposure to exvironmental chemicals2002
    • Author(s)
      Kumagai Y, Shimojo N.
    • Journal Title

      Environmental Health and Preventive Mdicine 7

      Pages: 141-150

    • NAID
    • Data Source
      KAKENHI-PROJECT-13680620

  • [Journal Article] Oxidatrion of proximal protein sulfhydryls by phenanthraquinone, a component of diesel exhaust uarticles2002
    • Author(s)
      Kumagai Y, Koide S, Taguchi K, et al.
    • Journal Title

      Chemical Research in Toxicology 15

      Pages: 483-489

    • NAID
    • Data Source
      KAKENHI-PROJECT-13672340

  • [Journal Article] Posaible Mechanisms for induction of oxidative stress and suppression of systemic nitric oxide production caused by exposure to environmental chemicals2002
    • Author(s)
      Kumagai Y, Shimojo N.
    • Journal Title

      Environmental Health and Preventive Medicine 7

      Pages: 141-150

    • NAID
    • Data Source
      KAKENHI-PROJECT-13672340

  • [Journal Article] Possible mechanisms for induction of oxidative stress and suppression of systemic nitric oxide production caused by exposure to environmental chemicals2002
    • Author(s)
      Kumagai Y, Shimojo N.
    • Journal Title

      Environmental Health and Perventive Medicine 7

      Pages: 141-150

    • NAID
      110004087642
    • Data Source
      KAKENHI-PROJECT-13576029

  • [Journal Article] Evidence for induction of oxidative stress caused by chronic eaposure of Chinese residents to arsenic contained in drinking water2002
    • Author(s)
      Pi JB, Yamauchi H, Kumagai Y, et al.
    • Journal Title

      Environmental Health Perspective 110

      Pages: 331-336

    • NAID
    • Data Source
      KAKENHI-PROJECT-13575036

  • [Journal Article] Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking water2002
    • Author(s)
      Pi JB, Yamauchi H, Kumagai Y, et al.
    • Journal Title

      Environmental Health Perspective 110

      Pages: 331-336

    • NAID
    • Data Source
      KAKENHI-PROJECT-13576029

  • [Journal Article] Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking water2002
    • Author(s)
      Pi JB, Yamauchi H, Kumagai Y, et al.
    • Journal Title

      Environmental Health Perspective 110

      Pages: 331-336

    • NAID
    • Data Source
      KAKENHI-PROJECT-13680620

  • [Journal Article] Phenanthraquinone affects endothelial nitric oxide synthase activity through modification of the thiol groups : An alternative inhibition machanism2001
    • Author(s)
      Taguchi K, Kumagai Y, Endo A, ei al.
    • Journal Title

      Journal of Health Sciences 47

      Pages: 571-574

    • NAID
    • Data Source
      KAKENHI-PROJECT-13672340

  • [Journal Article] Phenanthraquinone inhibits eNOS activity and suppresses vasorelaxation2001
    • Author(s)
      Kumagai Y, Hayashi T, Miyauchi T, et al.
    • Journal Title

      American Journal of Physiology 281

    • NAID
    • Data Source
      KAKENHI-PROJECT-13672340

  • [Journal Article] Induction of oxidative stress and dyafunction of nitric oxide-dependent vascular tone caused by quinones contained in diesel exhaust particles2001
    • Author(s)
      Kumagai Y, Shimojo N.
    • Journal Title

      Journal of Health Sciences 47

      Pages: 439-445

    • NAID
    • Data Source
      KAKENHI-PROJECT-13672340

  • [Presentation] 活性イオウ分子種定量解析システムの開発と新しいシステインパースルフィド合成酵素の発見2018
    • Author(s)
      井田智章、守田匡伸、魏　范研、松永哲郎、西村　明、居原　秀、澤　智裕、藤井重元、熊谷嘉人、本橋ほづみ、赤池孝章
    • Organizer
      第17回分子予防環境医学研究会
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Identification of a Sulfur Adduct of 1,4-Naphthoquinone during Reaction with a Polysulfide2018
    • Author(s)
      R Hirose, Y Shinkai, Y Abiko, Y Kumagai
    • Organizer
      Society of Toxicology 57th Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 1,4-NQ-Mediated Activation of PTEN/Akt/CREB Signaling in Primary Mouse Hepatocytes2018
    • Author(s)
      Y Abiko, Y Shinkai, T Unoki, R Hirose, T Uehara, Y Kumagai
    • Organizer
      Society of Toxicology 57th Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Cystathionine Gamma-Lyase Is a Key Protein Repressing Methylmercury Poisoning Symptoms in Mice2018
    • Author(s)
      M Akiyama, Y Shinkai, I Ishii, T Akaike, Y Kumagai
    • Organizer
      Society of Toxicology 57th Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Cadmium-Mediated Activation of the HSP90/ HSF1 Pathway Regulated by Reactive Persulfides and Polysulfides2018
    • Author(s)
      Y Shinkai, A Masuda, M Akiyama, M Xian, Y Kumagai
    • Organizer
      Society of Toxicology 57th Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 親電子ストレスを制御するレドックスシグナル伝達と活性イオウ分子2017
    • Author(s)
      熊谷嘉人
    • Organizer
      第39回日本薬学会九州支部コロキウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 親電子性金属に対する新たな防御応答システムの提案2017
    • Author(s)
      熊谷嘉人
    • Organizer
      メタルバイオサイエンス研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] メチル水銀のケミカルバイオロジー2017
    • Author(s)
      熊谷嘉人.
    • Organizer
      基盤（S）公開シンポジウム メチル水銀研究の現状と展望
    • Place of Presentation
      一の坊（宮城県、仙台市）
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 水銀が操る生体応答とトキシコロジー2017
    • Author(s)
      熊谷嘉人
    • Organizer
      第17回日本抗加齢医学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] レドックスシグナル伝達の可逆性担保における活性イオウ分子の役割.2017
    • Author(s)
      熊谷嘉人
    • Organizer
      第4回新学術領域研究「酸素生物学」全体班会議・公開シンポジウム
    • Place of Presentation
      九州大学（福岡県、福岡市）
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-15H01392

  • [Presentation] Environmental electrophiles activate redox signaling transduction pathways through covalent modification of sensor proteins2017
    • Author(s)
      Abiko Y, Kumagai Y
    • Organizer
      フォーラム2017：衛生薬学・環境トキシコロジー 日韓次世代シンポジウム
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 9,10- フェナントラキノンにより生じた活性酸素種によるプロテインチロシンフォスファターゼ活性阻害に対するパースルフィドおよびポリスルフィドの保護効果．2017
    • Author(s)
      Luong Cong Nho、安孫子ユミ、熊谷嘉人．
    • Organizer
      フォーラム2017：衛生薬学・環境トキシコロジー
    • Data Source
      KAKENHI-PUBLICLY-17H05519

  • [Presentation] 活性イオウ分子はカドミウムの不活性化を介して生体応答および肝毒性の惹起を負に制御する2017
    • Author(s)
      新開泰弘、秋山雅博、鵜木隆光、石井功、熊谷嘉人
    • Organizer
      フォーラム2017：衛生薬学・環境トキシコロジー
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] The phase-zero reaction: capture and inactivation of electrophiles by persulfides2017
    • Author(s)
      Kumagai Y
    • Organizer
      フォーラム2017：衛生薬学・環境トキシコロジー
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] ビスメチル水銀スルフィドの生成を介したニンニクのヘキサン抽出成分によるメチル水銀の毒性軽減2017
    • Author(s)
      Yunjie DING、安孫子ユミ、秋山雅博、熊谷嘉人
    • Organizer
      第44回日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 高血糖誘発性心不全の改善メカニズムにおけるTRPC6チャネルの役割2017
    • Author(s)
      小田紗矢香、冨田拓郎、北島直幸、外山喬士、原田英里、島内 司、西村明幸、石川達也、熊谷嘉人、Lutz Birnbaumer、西田基宏
    • Organizer
      第131回日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] カドミウムによるHSP90の化学修飾を介した転写因子HSF1の活性化と活性イオウ分子によるその制御2017
    • Author(s)
      鵜木隆光、新開泰弘、増田章、秋山雅博、Ming XIAN、熊谷嘉人
    • Organizer
      第44回日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 8-ニトロ-cGMPとタンパク質poly-S-グアニル化を介した親電子シグナル制御2017
    • Author(s)
      赤司壮一郎、笠松真吾、ジョン　ミンギョン、松永哲郎、井田智章、藤井重元、澤　智裕、熊谷嘉人、本橋ほづみ、赤池孝章
    • Organizer
      2017年度生理学研究所研究会「オルガネラダイナミクスの新規制御機構とその病態生理」
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 活性イオウ分子を介したカドミウムの肝毒性の防御機構2017
    • Author(s)
      新開泰弘、秋山雅博、鵜木隆光、石井功、熊谷嘉人
    • Organizer
      第70回日本酸化ストレス学会
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] ポリスルフィドNa2S4はイオウ付加体形成を通じて1,4-NQによる PTEN/ Akt/CREB シグナルの活性化と細胞毒性を抑制する2017
    • Author(s)
      鵜木隆光、安孫子ユミ、新開泰弘、広瀬玲子、上原孝、熊谷嘉人
    • Organizer
      フォーラム2017：衛生薬学・環境トキシコロジー
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] The chemical biology of environmental electrophiles2017
    • Author(s)
      Kumagai Y
    • Organizer
      Special seminar at University of Bordeaux school of Medicine
    • Int'l Joint Research / Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] マウスにおけるアクリルアミドの神経毒性に対する活性イオウ分子の役割2017
    • Author(s)
      秋山雅博、安孫子ユミ、熊谷嘉人
    • Organizer
      第70回日本酸化ストレス学会
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] アセトアミノフェン投与マウスにおけるアセトアミノフェンーイオウ付加体：新しい解毒機構.2017
    • Author(s)
      安孫子ユミ、石井功、鎌田祥太郎、土屋幸弘、渡邊泰男、居原秀、赤池孝章、熊谷嘉人.
    • Organizer
      第16回分子予防環境医学研究会
    • Place of Presentation
      熊本市国際交流会館（熊本県、熊本市）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] カドミウムによるHSP90の化学修飾を介する転写因子HSF1の活性化と活性イオウ分子によるその制御2017
    • Author(s)
      鵜木隆光、新開泰弘、増田章、秋山雅博、Xian Ming、熊谷嘉人
    • Organizer
      第70回日本酸化ストレス学会
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] メチル水銀を低毒性化する食用植物中生理活性物質としてのper/polysulfides2017
    • Author(s)
      片山優助、安孫子ユミ、秋山雅博、熊谷嘉人
    • Organizer
      第44回日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 1,4-NQ曝露によるPTEN/Akt/CREBシグナルの活性化はポリサルファイドモデル化合物Na2S4により抑制される2017
    • Author(s)
      安孫子ユミ、新開泰弘、鵜木隆光、広瀬怜子、上原孝、熊谷嘉人
    • Organizer
      第70回日本酸化ストレス学会
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 活性イオウ分子によるカドミウムの不活性化を介した肝毒性および生体応答の制御2017
    • Author(s)
      新開泰弘、秋山雅博、鵜木隆光、石井功、熊谷嘉人
    • Organizer
      第44回日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Reactive persulfide-dependent redox signaling in neuronal cells and its impairment by exposure to electrophiles2017
    • Author(s)
      Shigemoto Fujii, Hideshi Ihara, Shingo Kasamatsu, Akira Nishimura, Tomoaki Ida, Motohiro Nishida, Yoshito Kumagai, Takaaki Akaike
    • Organizer
      8th Joint Meeting of Society for Free Radical Research Australasia and Japan with International Symposium on Coenzyme Q10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] マウスにおけるアクリルアミドの神経毒性に対するCSEの役割2017
    • Author(s)
      秋山雅博、安孫子 ユミ、熊谷嘉人
    • Organizer
      第44回日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] ポリサルファイドモデル化合物Na2S4は1,4-NQ曝露によるPTEN/Akt/CREBシグナルの活性化を抑制する2017
    • Author(s)
      安孫子ユミ、新開泰弘、鵜木隆光、広瀬玲子、上原孝、熊谷嘉人
    • Organizer
      第44回日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 新規システインパースルフィド合成酵素の同定と機能解析2017
    • Author(s)
      井田智章、守田匡伸、魏　范研、松永哲郎、西村　明、Jung Minkyung、赤司壮一郎、居原　秀、澤　智裕、藤井重元、熊谷嘉人、富澤一仁、本橋ほづみ、赤池孝章
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 環境中電子受容体とパースルフィドとの反応で生じるパーチイルラジカル．2017
    • Author(s)
      安孫子ユミ、中井由実、Luong Cong Nho、熊谷嘉人．
    • Organizer
      フォーラム2017：衛生薬学・環境トキシコロジー
    • Data Source
      KAKENHI-PUBLICLY-17H05519

  • [Presentation] The chemical biolgy of environmental electrophiles2017
    • Author(s)
      Kumagai Y
    • Organizer
      Special seminar at National Taiwan University of School of Medicine
    • Int'l Joint Research / Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 高血糖誘発性心不全の改善メカニズムにおけるTRPC6チャネルの役割2017
    • Author(s)
      小田紗矢香、冨田拓郎、北島直幸、外山喬士、原田英里、島内 司、西村明幸、石川達也、熊谷嘉人、Lutz Birnbaumer、西田基宏
    • Organizer
      TRP研究会
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Environmental electrophile exposure and health2017
    • Author(s)
      Kumagai Y
    • Organizer
      National Conference of Toxicology2017
    • Int'l Joint Research / Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 新しいシステインパースルフィド産生酵素の同定と機能解析2017
    • Author(s)
      井田智章、守田匡伸、魏　范研、松永哲郎、西村　明、Jung Minkyung、赤司壮一郎、居原　秀、澤　智裕、藤井重元、熊谷嘉人、富澤一仁、本橋ほづみ、赤池孝章
    • Organizer
      2017年度生理学研究所研究会「オルガネラダイナミクスの新規制御機構とその病態生理」
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 活性イオウ分子およびその産生酵素は1,4-NQ曝露によるHSP90/HSF1シグナルの活性化を抑制する2017
    • Author(s)
      広瀬玲子、安孫子ユミ、新開泰弘、鵜木隆光、土屋幸弘、渡邊泰男、 赤池孝章、熊谷 嘉人
    • Organizer
      第44回日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Reactive oxygen species produced from 9,10-phenanthrenequinone activate epidermal growth factor receptor signaling through oxidative modification of protein tyrosine phosphatase 1B.2017
    • Author(s)
      Luong Cong Nho, Abiko Y, Kumagai Y.
    • Organizer
      第44回日本毒性学会学術年会
    • Data Source
      KAKENHI-PUBLICLY-17H05519

  • [Presentation] Environmental electrophiles: Modulation of redox signaling and interaction with persulfides/polysulfides.2017
    • Author(s)
      熊谷嘉人.
    • Organizer
      第90回日本細菌学会総会 国際シンポジウム
    • Place of Presentation
      仙台国際センター（宮城県、仙台市）
    • Int'l Joint Research / Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Is environmental electrophile an essential item for exposome?2017
    • Author(s)
      Kumagai Y
    • Organizer
      第44回日本毒性学会学術年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] CSE 欠損による親電子ストレスに対する感受性増強と CSE 高発現による還元 ストレスに対する生体応答2017
    • Author(s)
      秋山雅博、蕨栄治、鵜木隆光、新開泰弘、赤池孝章、熊谷嘉人
    • Organizer
      フォーラム2017：衛生薬学・環境トキシコロジー
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Capture of methylmercury by persulfides to form bismethylmercury sulfide.2016
    • Author(s)
      Abiko Y, Yoshida E, Ishii I, Fukuto JM, Akaike T, Kumagai Y.
    • Organizer
      IUTOX2016 XIV International Congress of Toxicology and X Mexican Congress of Toxicology
    • Place of Presentation
      Convention Center in Merida (Merida, Mexico)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 環境中親電子物質によるレドックスシグナル伝達の活性化と破綻.2016
    • Author(s)
      熊谷嘉人
    • Organizer
      第69回日本酸化ストレス学会学術集会
    • Place of Presentation
      仙台国際センター（宮城県、仙台市）
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-15H01392

  • [Presentation] The phase-zero reaction: capture of electrophiles mediated by reactive sulfur species.2016
    • Author(s)
      Kumagai Y.
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Stoweflake Conference Center (Stowe, USA)
    • Year and Date
      2016-08-08
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 環境中親電子物質によるレドックスシグナル伝達の活性化と破綻.2016
    • Author(s)
      熊谷嘉人.
    • Organizer
      第69回日本酸化ストレス学会学術集会
    • Place of Presentation
      仙台国際センター（宮城県、仙台市）
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 親電子プローブを用いたMRM-MS による生体試料中の活性イオウ分子の定量法の構築.2016
    • Author(s)
      新開泰弘、秋山雅博、鵜木隆光、井田智章、赤池孝章、熊谷嘉人.
    • Organizer
      フォーラム2016 衛生薬学・環境トキシコロジー
    • Place of Presentation
      昭和大学旗の台キャンパス（東京都、品川区）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Translation-coupled protein polysulfuration, a unique biosynthesis pathway of cysteine persulfide.2016
    • Author(s)
      Ida T, Ihara H, Wei F, Tomozawa K, Kasamatsu S, Morita M, Matsunaga T, Kumagai Y, Sawa T, Motohashi H, Fujii S, Akaike T.
    • Organizer
      The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
    • Place of Presentation
      仙台国際センター（宮城県、仙台市）
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] カドミウムによるHSP90の化学修飾を介した転写因子HSF1の活性化とその防御的役割.2016
    • Author(s)
      新開泰弘、増田章、熊谷嘉人.
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち（愛知県、名古屋市）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Cystathionine gamma-lyase はメチル水銀中毒症状を抑制する鍵分子である.2016
    • Author(s)
      秋山雅博、安孫子ユミ、新開泰弘、鵜木隆光、Ding Yunjie、外山喬士、吉田映子、熊谷嘉人.
    • Organizer
      フォーラム2016 衛生薬学・環境トキシコロジー
    • Place of Presentation
      昭和大学旗の台キャンパス（東京都、品川区）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 活性イオウ分子によるカドミウムの毒性防御の分子機構.2016
    • Author(s)
      新開泰弘、熊谷嘉人.
    • Organizer
      第69回日本酸化ストレス学会学術集会
    • Place of Presentation
      仙台国際センター（宮城県、仙台市）
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 親電子物質/電子受容体で活性イオウ分子の役割を探る.2016
    • Author(s)
      熊谷嘉人
    • Organizer
      第12回レドックスイノベーションシンポジウム
    • Place of Presentation
      熊本大学（熊本県、熊本市）
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-15H01392

  • [Presentation] 親電子・活性イオウ分子付加体の化学と解析法.2016
    • Author(s)
      安孫子ユミ、新開泰弘、熊谷嘉人.
    • Organizer
      新学術領域研究 ｢酸素生物学｣ 第3回技術支援セミナー
    • Place of Presentation
      名古屋大学シンポジオン（愛知県・名古屋市）
    • Year and Date
      2016-01-23
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Generation of cystathionine γ-lyase overexpressing Tg mouse.2016
    • Author(s)
      Warabi E, Kumagai Y.
    • Organizer
      The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
    • Place of Presentation
      仙台国際センター（宮城県、仙台市）
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Methylmercury activates and disrupts the Akt/CREB/Bcl-2 signal transduction pathway in SH-SYSY cells.2016
    • Author(s)
      Kumagai Y, Unoki T, Abiko Y, Toyama T.
    • Organizer
      The 52nd European Congress of the European Societies of Toxicology
    • Place of Presentation
      FEBES, Conference and Exhibition Centre (Seville, Spain)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 1,4-Naphthoquinone-mediated activation of the HSP90/HSF1 signal transduction pathway and its negative regulation by reactive sulfur species in human A431 cells.2016
    • Author(s)
      Unoki T, Shinkai Y, Sha L, Hirose R, Kumagai Y.
    • Organizer
      IUTOX2016 XIV International Congress of Toxicology and X Mexican Congress of Toxicology
    • Place of Presentation
      Convention Center in Merida (Merida, Mexico)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 環境中に存在する親電子物質および電子受容体で活性イオウ分子の役割を探る.2016
    • Author(s)
      熊谷嘉人
    • Organizer
      オルガネラ研究会2016
    • Place of Presentation
      生理学研究所（愛知県、岡崎市）
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-15H01392

  • [Presentation] 1,4-naphthoquinone-mediated activation of the HSP90/HSF1 signal transduction pathway and its modulation by reactive sulfur species in human A431 cells.2016
    • Author(s)
      Unoki T, Shinkai Y, Sha L, Kumagai Y.
    • Organizer
      Society of Toxicology 55th Annual Meeting
    • Place of Presentation
      New Orleans（アメリカ）
    • Year and Date
      2016-03-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Reactive sulfur species as a regulator molecule for the phase-zero reaction to attenuate reactivity of electrophiles.2016
    • Author(s)
      Kumagai Y
    • Organizer
      The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
    • Place of Presentation
      仙台国際センター（宮城県、仙台市）
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] アセトアミノフェンの新規代謝経路：イオウ付加体の同定.2016
    • Author(s)
      安孫子ユミ、石井功、鎌田祥太郎、土屋幸弘、渡邊泰男、居原秀、赤池孝章、熊谷嘉人.
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち（愛知県、名古屋市）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Coriandrum sativum L.葉抽出液中の脂肪族親電子物質によるNrf2活性化 および無機三価ヒ素の細胞毒性軽減.2016
    • Author(s)
      安孫子ユミ、溝河真衣、里見綾香、熊谷嘉人.
    • Organizer
      第22回ヒ素シンポジウム
    • Place of Presentation
      産総研臨界副都心センター（東京都、港区）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 活性イオウ分子によるカドミウムの毒性防御.2016
    • Author(s)
      鵜木隆光、新開泰弘、秋山雅博、熊谷嘉人.
    • Organizer
      第32回臨床フリーラジカル会議
    • Place of Presentation
      京都・烟河（京都府・亀岡市）
    • Year and Date
      2016-01-29
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Protein poly-S-guanylation: Reversible post-translational modification regulated by protein polysulfur and 8-nitrocGMP.2016
    • Author(s)
      Akashi S, Kasamatsu S, Jung M, Matsunaga T, Ida T, Fujii S, Sawa T, Kumagai Y, Motohashi H, Akaike T.
    • Organizer
      The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
    • Place of Presentation
      仙台国際センター（宮城県、仙台市）
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Role of reactive sulfur species as a key molecule to diminish toxicity of the environmental electrophile in mice.2016
    • Author(s)
      Akiyama M, Toyama T, Yoshida E, Unoki T, Abiko Y, Shinkai Y, Kumagai Y.
    • Organizer
      The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
    • Place of Presentation
      仙台国際センター（宮城県、仙台市）
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 環境中に存在する親電子物質および電子受容体で活性イオウ分子の役割を探る.2016
    • Author(s)
      熊谷嘉人.
    • Organizer
      オルガネラ研究会2016
    • Place of Presentation
      生理学研究所（愛知県、岡崎市）
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 親電子物質による生体影響の二面性：SH-SY5Y 細胞におけるメチル水銀曝露により生じるAkt/CREB/Bcl-2 経路の活性化と破綻.2016
    • Author(s)
      鵜木隆光、安孫子ユミ、外山喬士、上原孝、坪井康次、西田基宏、鍜冶利幸、熊谷嘉人.
    • Organizer
      フォーラム2016 衛生薬学・環境トキシコロジー
    • Place of Presentation
      昭和大学旗の台キャンパス（東京都、品川区）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Protective effect of sodium tetrasulfide on covalent modification of cellular proteins and cellular toxicity mediated by 1,4-naphthoquinone, an atmospheric electrophile.2016
    • Author(s)
      Hirose R, Unoki T, Shinkai Y, Abiko Y, Kumagai Y.
    • Organizer
      Society of Toxicology 55th Annual Meeting
    • Place of Presentation
      New Orleans（アメリカ）
    • Year and Date
      2016-03-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] メチル水銀曝露による健康リスクを制御する活性イオウ分子の役割.2016
    • Author(s)
      秋山雅博、外山喬士、吉田映子、鵜木隆光、安孫子ユミ、新開泰弘、熊谷嘉人.
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち（愛知県、名古屋市）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 親電子シグナルを制御する活性イオウ分子.2016
    • Author(s)
      熊谷嘉人
    • Organizer
      日本薬学会第136年会（横浜）2016年3/28
    • Place of Presentation
      パシフィコ横浜（神奈川県・横浜市）
    • Year and Date
      2016-03-26
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 1,4-ナフトキノンによるHSF90/HSF1経路の活性化と活性イオウ分子によるその制御.2016
    • Author(s)
      鵜木隆光、新開泰弘、沙亮、広瀬玲子、熊谷嘉人.
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち（愛知県、名古屋市）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Paraquat-generated reactive oxygen species activate epidermal growth factor receptor signaling pathway in A431 cells.2016
    • Author(s)
      Luong CN, Abiko Y, Kumagai Y.
    • Organizer
      フォーラム2016 衛生薬学・環境トキシコロジー
    • Place of Presentation
      昭和大学旗の台キャンパス（東京都、品川区）
    • Data Source
      KAKENHI-PUBLICLY-15H01392

  • [Presentation] カドミウムの肝毒性に対する活性イオウ分子の防御的役割.2016
    • Author(s)
      新開泰弘、秋山雅博、鵜木隆光、熊谷嘉人.
    • Organizer
      オルガネラ研究会2016
    • Place of Presentation
      生理学研究所（愛知県、岡崎市）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] The chemical biology of electrophiles and reactive sulfur species.2016
    • Author(s)
      Kumagai Y.
    • Organizer
      The special seminar for visiting professor of China Medical University
    • Place of Presentation
      China Medical University（Shenyang, China）
    • Year and Date
      2016-04-25
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Activation of Nrf2 through S-transmerculation of methylmercury glutathione adduct to Keap1 in SH-SY5Y cells.2016
    • Author(s)
      Abiko Y, Yoshida E, Kumagai Y.
    • Organizer
      Society of Toxicology 55th Annual Meeting
    • Place of Presentation
      New Orleans（アメリカ）
    • Year and Date
      2016-03-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 親電子物質/電子受容体で活性イオウ分子の役割を探る.2016
    • Author(s)
      熊谷嘉人.
    • Organizer
      第12回レドックスイノベーションシンポジウム
    • Place of Presentation
      熊本大学（熊本県、熊本市）
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] カドミウムによるレドックスシグナル伝達経路の活性化とその制御系.2016
    • Author(s)
      新開泰弘、熊谷嘉人.
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター（宮城県、仙台市）
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Role of cystathionine gamma-lyase in the health risks of methylmercury.2016
    • Author(s)
      Akiyama M, Toyama T, Yoshida E, Unoki T, Abiko Y, Shinkai Y, Kumagai Y.
    • Organizer
      Society of Toxicology 55th Annual Meeting
    • Place of Presentation
      New Orleans（アメリカ）
    • Year and Date
      2016-03-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 親電子・活性イオウ分子付加体の化学と解析法.2016
    • Author(s)
      安孫子ユミ、新開泰弘、熊谷嘉人.
    • Organizer
      新学術領域研究 ｢酸素生物学｣ 第3回技術支援セミナー
    • Place of Presentation
      名古屋大学シンポジオン（愛知県・名古屋市）
    • Year and Date
      2016-01-23
    • Data Source
      KAKENHI-PUBLICLY-15H01392

  • [Presentation] フェーズゼロ反応：活性イオウ分子による親電子物質の捕獲.2016
    • Author(s)
      熊谷嘉人.
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター（宮城県、仙台市）
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 環境中親電子物質による活性イオウ分子の捕獲とそれに伴うレドックスホメオスタシスの撹乱.2016
    • Author(s)
      熊谷嘉人
    • Organizer
      第89回日本薬理学会年会 日本薬理学会・日本毒性学会共催シンポジウム
    • Place of Presentation
      パシフィコ横浜（神奈川県・横浜市）
    • Year and Date
      2016-03-09
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Capture of reactive sulfur species by methylmercury to form bismethylmercury sulfide: Implication of the disruptionof redox homeostasis.2016
    • Author(s)
      Abiko Y, Yoshida E, Ishii I, Fukuto JM, Akaike T, Kumagai Y.
    • Organizer
      The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
    • Place of Presentation
      仙台国際センター（宮城県）
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Sodium tetrasulfide, a reactive sulfur species, protects cells from 1,4-naphthoquinone induced cytotoxicity through sulfur adduct formation.2016
    • Author(s)
      Unoki T, Shinkai Y, Abiko Y, Hirose R, Kumagai Y.
    • Organizer
      The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
    • Place of Presentation
      仙台国際センター（宮城県、仙台市）
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 反応性環境物質によるタンパク質の化学修飾とそれに対する生体防御系.2016
    • Author(s)
      熊谷嘉人.
    • Organizer
      第89回産業衛生学会教育講演
    • Place of Presentation
      福島県文化センター（福島県、福島市）
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] メチル水銀による活性イオウ分子の捕獲.2016
    • Author(s)
      安孫子ユミ 、吉田映子、熊谷嘉人.
    • Organizer
      第15回分子予防環境医学研究会大会
    • Place of Presentation
      自治医科大学（栃木県・下野市）
    • Year and Date
      2016-01-29
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] An atmospheric electrophile activates heat shock factor 1 through S-arylation of heat shock protein 90.2016
    • Author(s)
      Hirose R, Unoki T, Abiko Y, Shinkai Y, Sha R, Kumagai Y.
    • Organizer
      The 52nd European Congress of the European Societies of Toxicology
    • Place of Presentation
      FEBES, Conference and Exhibition Centre (Seville, Spain)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] アセトアミノフェンの新規イオウ付加体の同定.2016
    • Author(s)
      安孫子ユミ、石井功、鎌田祥太郎、土屋幸弘、渡邊泰男、居原秀、赤池孝章、熊谷嘉人.
    • Organizer
      フォーラム2016 衛生薬学・環境トキシコロジー
    • Place of Presentation
      昭和大学旗の台キャンパス（東京都、品川区）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Role of Reactive Sulfur Species in Detoxification of Methylmercury: Phase Zero Reaction for Electrophile Trapping and Detoxification.2016
    • Author(s)
      Kumagai Y
    • Organizer
      Society of Toxicology 55th Annual Meeting Society of Toxicology and Japanese Society of Toxicology Mini-Symposium
    • Place of Presentation
      New Orleans（アメリカ）
    • Year and Date
      2016-03-13
    • Int'l Joint Research / Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] メチル水銀による活性イオウ分子の捕獲とそれに伴うレドックスホメオスタシスの破綻.2016
    • Author(s)
      熊谷嘉人.
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち（愛知県、名古屋市）
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] The phase-zero reaction: caputure of electrophiles by reactive sulfur species.2016
    • Author(s)
      Kumagai Y.
    • Organizer
      The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. Satellite Symposium on Chemical Biology of Reactive Persulfide
    • Place of Presentation
      東北大学医学部（宮城県、仙台市）
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 活性イオウ分子Na2S4はイオウ付加体形成を通じて1,4-NQによる細胞毒性を軽減する.2015
    • Author(s)
      鵜木隆光、新開泰弘、熊谷嘉人.
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      石川県立音楽堂他（石川県・金沢市）
    • Year and Date
      2015-06-29
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 活性システインパースルフィドのメタボロミクスとプロテオミクス.2015
    • Author(s)
      井田智章、居原　秀、澤　智裕、土屋幸弘、渡邊泰男、藤井重元、熊谷嘉人、本橋ほづみ、赤池孝章.
    • Organizer
      第68回日本酸化ストレス学会学術集会
    • Place of Presentation
      かごしま県民交流センター（鹿児島県・鹿児島市）
    • Year and Date
      2015-06-11
    • Data Source
      KAKENHI-PUBLICLY-15H01392

  • [Presentation] 親電子物質のケミカルバイオロジー：化学修飾を介したレドックスシグナル伝達および毒性発現とそれらを制御する活性イオウ分子.2015
    • Author(s)
      熊谷嘉人
    • Organizer
      持田製薬株式会社 創薬研究所セミナー
    • Place of Presentation
      持田製薬創薬研究所（静岡県・御殿場市）
    • Year and Date
      2015-10-14
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Reactive sulfur species and reactive oxygen species-mediated reversible activation of the Keap1-Nrf2 pathway by 1,2-napthoquinone.2015
    • Author(s)
      Shinkai Y, Miura T, Kakehashi H, Akaike T, Kumagai Y.
    • Organizer
      The 7th International Congress of Asian Society of Toxicology
    • Place of Presentation
      Jeju（韓国）
    • Year and Date
      2015-06-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 有機水銀の神経毒性発現における8-ニトロ-cGMPの役割と活性イオウ分子による制御.2015
    • Author(s)
      藤井重元、笠松真吾、居原秀、津々木博康、石崎健勝、井田智章、澤智裕、熊谷嘉人、赤池孝章.
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド（兵庫県・神戸市）
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] メチル水銀曝露による健康リスクに対する活性イオウ分子の役割.2015
    • Author(s)
      秋山雅博、外山喬士、吉田映子、鵜木隆光、安孫子ユミ、新開泰弘、熊谷嘉人.
    • Organizer
      フォーラム2015：衛生薬学・環境トキシコロジー
    • Place of Presentation
      神戸学院大学（兵庫県・神戸市）
    • Year and Date
      2015-09-17
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] カドミウムによる親電子シグナル伝達経路の活性化と活性イオウ分子による修飾.2015
    • Author(s)
      新開泰弘、鵜木隆光、鍜冶利幸、熊谷嘉人.
    • Organizer
      第10回メタルバイオサイエンス研究会
    • Place of Presentation
      名古屋国際センター ホール（愛知県・名古屋市）
    • Year and Date
      2015-08-27
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] カドミウムの防御応答に関わるHSP/HSF1経路の活性化と活性イオウ分子によるその制御.2015
    • Author(s)
      増田章、新開泰弘、熊谷嘉人.
    • Organizer
      フォーラム2015：衛生薬学・環境トキシコロジー
    • Place of Presentation
      神戸学院大学（兵庫県・神戸市）
    • Year and Date
      2015-09-17
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 親電子物質のレドックスシグナル伝達変動とそれを制御する活性イオウ分子2015
    • Author(s)
      熊谷嘉人
    • Organizer
      生理学研究所生体情報研究系心循環シグナル研究部門公開セミナー
    • Place of Presentation
      自然科学研究機構岡崎統合バイオサイエンスセンター（愛知県・岡崎市）
    • Year and Date
      2015-03-16
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Chemical Biology of Electrophiles.2015
    • Author(s)
      Kumagai Y
    • Organizer
      CEPID-Redoxoma seminar in University of Sao Paulo
    • Place of Presentation
      Sao Paulo（ブラジル）
    • Year and Date
      2015-11-11
    • Int'l Joint Research / Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Methylmercury glutathione adduct activates Nrf2 through S-transmercuration to Keap1 in SH-SY5Y cells.2015
    • Author(s)
      Abiko Y, Yoshida E, Kumagai Y.
    • Organizer
      The 7th International Congress of Asian Society of Toxicology
    • Place of Presentation
      Jeju（韓国）
    • Year and Date
      2015-06-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 環境中親電子物質によるタンパク質の化学修飾を介したシグナル伝達活性化.2015
    • Author(s)
      熊谷嘉人
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      石川県立音楽堂他（石川県・金沢市）
    • Year and Date
      2015-06-29
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Glutathione adduct of methylmercury activates Nrf2 through covalent modification of Keap1in SH-SY5Y Cells.2015
    • Author(s)
      Kumagai Y, Abiko Y, Yoshida E.
    • Organizer
      2015 International Chemical Congress of Pacific Basin Societies.
    • Place of Presentation
      Honolulu（アメリカ）
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] タンパク質ポリサルファ化の分子メカニズムの解明.2015
    • Author(s)
      井田智章、居原秀、魏范研、富澤一仁、長尾翌手可、鈴木勉、熊谷嘉人、澤智裕、笠松真吾、本橋ほづみ、赤池孝章.
    • Organizer
      第88回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド（兵庫県・神戸市）
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PUBLICLY-15H01392

  • [Presentation] メチル水銀による活性イオウ分子の捕獲とそれに伴う生体内レドックスホメオスタシスの変動.2015
    • Author(s)
      安孫子ユミ、吉田映子、熊谷嘉人.
    • Organizer
      第10回メタルバイオサイエンス研究会
    • Place of Presentation
      名古屋国際センター ホール（愛知県・名古屋市）
    • Year and Date
      2015-08-27
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] タンパク質poly-S-グアニル化を介した親電子シグナルの可逆的制御.2015
    • Author(s)
      赤司壮一郎、笠松真吾、ジョンミンギョン、松永哲郎、井田智章、藤井重元、澤智裕、熊谷嘉人、本橋ほづみ、赤池孝章.
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド（兵庫県・神戸市）
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] タンパク質poly-S-グアニル化を介した親電子シグナルの可逆的制御.2015
    • Author(s)
      赤司壮一郎、笠松真吾、ジョンミンギョン、松永哲郎、井田智章、藤井重元、澤智裕、熊谷嘉人、本橋ほづみ、赤池孝章.
    • Organizer
      第88回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド（兵庫県・神戸市）
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PUBLICLY-15H01392

  • [Presentation] Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion．2015
    • Author(s)
      石井功、中埜信太郎、新村健、玉城香代子、菱木貴子、赤星軌征、井田智章、中西豪、鎌田祥太郎、熊谷嘉人、赤池孝章、福田恵一、佐野元昭、末松誠．
    • Organizer
      第16回Pharmaco-Hematologyシンポジウム
    • Place of Presentation
      日本薬学会 長井記念ホール（東京都・渋谷区）
    • Year and Date
      2015-06-13
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Biotin-(PEAC)5-maleimide-ELISAを用いた親電子性キノン化合物によるタンパク質修飾の簡便アッセイの提案.2015
    • Author(s)
      安孫子ユミ、Nho Cong Luong、熊谷嘉人.
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      石川県立音楽堂他（石川県・金沢市）
    • Year and Date
      2015-06-29
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 活性イオウ分子と酸化ストレスが介在する1,2-ナフトキノンによる可逆的なKeap1-Nrf2経路の活性化．2015
    • Author(s)
      新開泰弘、三浦高、掛橋秀直、赤池孝章、熊谷嘉人．
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      石川県立音楽堂他（石川県・金沢市）
    • Year and Date
      2015-06-29
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 親電子物質の不活性化に関与する活性イオウ分子：フェーズゼロ反応の提案.2015
    • Author(s)
      熊谷嘉人:
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      石川県立音楽堂他（石川県・金沢市）
    • Year and Date
      2015-06-29
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] タンパク質S－ポリチオール化による親電子シグナル制御.2015
    • Author(s)
      赤司壮一郎、笠松真吾、Jung Minkyung、松永哲郎、井田智章、藤井重元、本橋ほづみ、澤　智裕、熊谷嘉人、赤池孝章.
    • Organizer
      第68回日本酸化ストレス学会学術集会
    • Place of Presentation
      かごしま県民交流センター（鹿児島県・鹿児島市）
    • Year and Date
      2015-06-11
    • Data Source
      KAKENHI-PUBLICLY-15H01392

  • [Presentation] システイン・活性イオウ分子産生酵素CSEのアセトアミノフェン肝障害における保護的役割.2015
    • Author(s)
      石井功、安孫子ユミ、鎌田祥太郎、熊谷嘉人.
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      石川県立音楽堂他（石川県・金沢市）
    • Year and Date
      2015-06-29
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 活性システインパースルフィドのメタボロミクスとプロテオミクス.2015
    • Author(s)
      井田智章、居原　秀、澤　智裕、土屋幸弘、渡邊泰男、藤井重元、熊谷嘉人、本橋ほづみ、赤池孝章.
    • Organizer
      第68回日本酸化ストレス学会学術集会
    • Place of Presentation
      かごしま県民交流センター（鹿児島県・鹿児島市）
    • Year and Date
      2015-06-11
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 生体内でのメチル水銀解毒代謝におけるCSEの役割.2015
    • Author(s)
      秋山雅博、外山喬士、吉田映子、鵜木隆光、安孫子ユミ、新開泰弘、熊谷嘉人.
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      石川県立音楽堂他（石川県・金沢市）
    • Year and Date
      2015-06-29
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] A431細胞における9,10- フェナントラキノン曝露により生じる活性酸素種によるEGFR/ERK シグナルの活性化.2015
    • Author(s)
      Luong Cong Nho、安孫子ユミ、熊谷嘉人.
    • Organizer
      フォーラム2015：衛生薬学・環境トキシコロジー
    • Place of Presentation
      神戸学院大学（兵庫県・神戸市）
    • Year and Date
      2015-09-17
    • Data Source
      KAKENHI-PUBLICLY-15H01392

  • [Presentation] 親電子性キノン化合物によるタンパク質修飾のBiotin-(PEAC)5-maleimide-ELISA を用いた検出.2015
    • Author(s)
      安孫子ユミ、Luong Cong Nho、熊谷嘉人.
    • Organizer
      フォーラム2015：衛生薬学・環境トキシコロジー
    • Place of Presentation
      神戸学院大学（兵庫県・神戸市）
    • Year and Date
      2015-09-17
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Contribution of the Keap1-Nrf2 pathway and CBS/CSE to produce reactive sulfur species to protection against methylmercury.2015
    • Author(s)
      Kumagai Y
    • Organizer
      The 9th Congress of Toxicology in Developing Countries
    • Place of Presentation
      Natal（ブラジル）
    • Year and Date
      2015-11-07
    • Int'l Joint Research / Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 有機水銀の神経毒性発現における8-ニトロ-cGMPの役割と活性イオウ分子による制御.2015
    • Author(s)
      藤井重元、笠松真吾、居原秀、津々木博康、石崎健勝、井田智章、澤智裕、熊谷嘉人、赤池孝章.
    • Organizer
      第88回日本生化学会大会、2015年　12/3
    • Place of Presentation
      神戸ポートアイランド（兵庫県・神戸市）
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PUBLICLY-15H01392

  • [Presentation] タンパク質S－ポリチオール化による親電子シグナル制御.2015
    • Author(s)
      赤司壮一郎、笠松真吾、Jung Minkyung、松永哲郎、井田智章、藤井重元、本橋ほづみ、澤　智裕、熊谷嘉人、赤池孝章.
    • Organizer
      第68回日本酸化ストレス学会学術集会
    • Place of Presentation
      かごしま県民交流センター（鹿児島県・鹿児島市）
    • Year and Date
      2015-06-11
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] タンパク質ポリサルファ化の分子メカニズムの解明.2015
    • Author(s)
      井田智章、居原秀、魏范研、富澤一仁、長尾翌手可、鈴木勉、熊谷嘉人、澤智裕、笠松真吾、本橋ほづみ、赤池孝章.
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド（兵庫県・神戸市）
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Dynamin-related protein 1の酸化修飾による病的心臓リモデリング制御2015
    • Author(s)
      西田基宏、西村明幸、永井直杜、外山喬士、冨田（沼賀）拓郎、熊谷嘉人、赤池孝章
    • Organizer
      第15回日本ＮＯ学会学術集会
    • Place of Presentation
      千里ライフサイエンスセンター（大阪府・豊中市）
    • Year and Date
      2015-06-26
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Activation of the Keap1/Nrf2 pathway through covalent modification of the 2-alkenal group of aliphatic electrophiles in Coriandrum sativum L.2015
    • Author(s)
      Kumagai Y
    • Organizer
      The 7th International Congress of Asian Society of Toxicology
    • Place of Presentation
      Jeju（韓国）
    • Year and Date
      2015-06-23
    • Int'l Joint Research / Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Chemical Biology of Electrophiles.2015
    • Author(s)
      Kumagai Y
    • Organizer
      CEPID-Redoxoma seminar in University of Sao Paulo
    • Place of Presentation
      サンパウロ（ブラジル）
    • Year and Date
      2015-11-11
    • Int'l Joint Research / Invited
    • Data Source
      KAKENHI-PUBLICLY-15H01392

  • [Presentation] 心虚血再灌流障害におけるホモシステインの新規作用機序.2015
    • Author(s)
      石井功、中埜信太郎、新村健、玉城香代子、菱木貴子、赤星軌征、井田智章、中西豪、鎌田祥太郎、熊谷嘉人、赤池孝章、福田恵一、佐野元昭、末松誠.
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド（兵庫県・神戸市）
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Environmental electrophiles-mediated modulation of redox signal transduction pathways and toxicity regulated by reactive sulfur species.2015
    • Author(s)
      Kumagai Y
    • Organizer
      2015 International Conference on Industrial Hygiene and Occupational Medicine
    • Place of Presentation
      高雄（台湾）
    • Year and Date
      2015-04-25
    • Int'l Joint Research / Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Ambient Vaper Samples Acrivate the Nrf2-ARE Pathway but Not an Inflammatory Response in Human Bronchial Epithelial BEAS-2B Cells.2014
    • Author(s)
      Shinkai Y, Nakajima S, Eiguren-Fernandez A, Stefano ED, Schmitz DA, Froines JR, Cho AK, Kumagai Y.
    • Organizer
      Society of Toxicology 53th Annual Meeting
    • Place of Presentation
      Phoenix Convention Center (Phoenix, USA)
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Identification of phytochemicals from Coriandrum sativum L. leaf extract to activate Nrf2 through electrophilic modification of the 2-alkenal group.2014
    • Author(s)
      Abiko Y, Mizokawa M, Kumagai Y.
    • Organizer
      The Environmental Response IV
    • Place of Presentation
      東北大学さくらホール（宮城県仙台市）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Proteomics Analysis to Identify Sensor Proteins with Covalent Modification Associated with 1,4-Naphthoquinone-Induced Activation of Electrophilic Signal Transduction Pathways.2014
    • Author(s)
      Hirose R, Miura T, Sha R, Shinkai Y, Tanaka-Kagawa T, Kumagai Y.
    • Organizer
      Society of Toxicology 53th Annual Meeting
    • Place of Presentation
      Phoenix Convention Center (Phoenix, USA)
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 芳香族炭化水素キノン類による芳香族炭化水素受容体の活性化.2014
    • Author(s)
      安孫子ユミ、Puga Alvaro、熊谷嘉人
    • Organizer
      第13回分子予防環境医学研究会
    • Place of Presentation
      和歌山県民文化会館（和歌山県和歌山市）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Cooperative role of the Keap1-Nrf2 pathway and CBS/CSE in methyl mercury toxicity.2014
    • Author(s)
      Kumagai Y.
    • Organizer
      The Environmental Response IV
    • Place of Presentation
      東北大学さくらホール（宮城県仙台市）
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Regulation of Covalent Modification of 2-Tert-Butyl-1,4-Benzoquinone to Keap1 through Glutathione-Mediated S-Transarylation.2014
    • Author(s)
      Abiko Y, Kumagai Y.
    • Organizer
      Society of Toxicology 53th Annual Meeting
    • Place of Presentation
      Phoenix Convention Center (Phoenix, USA)
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Role of Reactive Sulfur Species in Reduction of Methylmercury Toxicity In Vitro and In Vivo.2014
    • Author(s)
      Yoshida E, Toyama T, Kumagai Y.
    • Organizer
      Society of Toxicology 53th Annual Meeting
    • Place of Presentation
      Phoenix Convention Center (Phoenix, USA)
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 活性硫黄種によるレドックス恒常性維持機構に基づいた新規心不全治療戦略の構築.2014
    • Author(s)
      西田基宏、外山喬士、熊谷嘉人、冨田拓郎
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学（熊本県熊本市）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 環境中親電子物質のケミカルバイオロジー： 化学修飾を介したシグナル伝達の変動および毒性発現とそれらを制御する活性イオウ分子.2014
    • Author(s)
      熊谷嘉人
    • Organizer
      東北薬科大学創薬研究センターシンポジウム
    • Place of Presentation
      東北薬科大学（宮城県・仙台市）
    • Year and Date
      2014-06-14
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 環境中親電子物質のケミカルバイオロジー.2014
    • Author(s)
      熊谷嘉人
    • Organizer
      日本薬学会九州支部特別講演会
    • Place of Presentation
      第一薬科大学（福岡県・福岡市）
    • Year and Date
      2014-10-25
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Activation of Nrf1/ARE pathway by cadmium in vascular endothelial cells.2014
    • Author(s)
      Shinkai Y, Kaji T, Kumagai Y.
    • Organizer
      The Environmental Response IV
    • Place of Presentation
      東北大学さくらホール（宮城県仙台市）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 親電子物質の反応性を制御する活性イオウ分子：フェーズゼロ反応の提案.2014
    • Author(s)
      熊谷嘉人
    • Organizer
      レドックスシンポジウム：酸素生物学の誕生
    • Place of Presentation
      名古屋大学ES総合館ESホール（愛知県・名古屋市）
    • Year and Date
      2014-10-11
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Activation of Nrf1/ARE pathway by cadmium in vascular endothelial cells2014
    • Author(s)
      Yasuhiro Shinkai, Toshiyuki Kaji, Yoshito Kumagai
    • Organizer
      The Environmental Response
    • Place of Presentation
      東北大学片平さくらホール（宮城県仙台市）
    • Data Source
      KAKENHI-PROJECT-24590159

  • [Presentation] メチル水銀とそのグルタチオン抱合体によるKeap1/Nrf2 経路の活性化2013
    • Author(s)
      新開泰弘、吉田映子、外山喬士、熊谷嘉人
    • Organizer
      環境省 メチル水銀研究ミーティング
    • Place of Presentation
      ＬＭＪ東京研修センター（東京都文京区）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Role of the keap1/Nrf2 pathway in methylmercury-mediated neurotoxicity.2013
    • Author(s)
      Kumagai Y
    • Organizer
      The XIII International Congress of Toxicology
    • Place of Presentation
      COEX Convention Center（韓国ソウル）
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] グルタチオンによるユビキチンC末端加水分解酵素L1の親電子修飾の可逆性.2013
    • Author(s)
      外山喬士、矢澤亜季、鍛冶利幸、熊谷嘉人
    • Organizer
      フォーラム2013：衛生薬学・環境トキシコロジー
    • Place of Presentation
      九州大学医学部百年講堂（福岡県福岡市）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] タンパク質の化学修飾を生じる環境中親電子物質のケミカルバイオロジー.2013
    • Author(s)
      熊谷嘉人
    • Organizer
      フォーラム2013：衛生薬学・環境トキシコロジー学術賞受賞講演
    • Place of Presentation
      九州大学医学部百年講堂（福岡県福岡市）
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] メチル水銀と活性イオウ分子2013
    • Author(s)
      熊谷嘉人
    • Organizer
      環境省 メチル水銀研究ミーティング
    • Place of Presentation
      ＬＭＪ東京研修センター（東京都文京区）
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Activation of Heat Shock Response during exposure of human epithelial A431 cells to an environmental electrophile, 1,4-naphthoquinone2013
    • Author(s)
      Sha R, Shinkai Y, Kumagai Y.
    • Organizer
      第12回分子予防環境医学研究会
    • Place of Presentation
      つくば
    • Year and Date
      2013-02-02
    • Data Source
      KAKENHI-PROJECT-22406004

  • [Presentation] 環境中親電子物質の有害性を制御する活性イオウ分子.2013
    • Author(s)
      熊谷嘉人
    • Organizer
      第24回日本生体防御学会学術総会
    • Place of Presentation
      くまもと森都心プラザ｣プラザホール（熊本県熊本市）
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 転写因子Nrf2の活性化能を有するCoriandrum sativum L. 葉抽出物に含有される脂肪族親電子物質の同定.2013
    • Author(s)
      溝河真衣、安孫子ユミ、新開泰弘、熊谷嘉人
    • Organizer
      フォーラム2013：衛生薬学・環境トキシコロジー
    • Place of Presentation
      九州大学医学部百年講堂（福岡県福岡市）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] GSH-mediates S-Transarylation regulates covalent modification of Keap1 by tert-butylbenzoquinone.2013
    • Author(s)
      Abiko Y, Miura T, Bui H Phuc, Shinkai Y, Kumagai Y.
    • Organizer
      The XIII International Congress of Toxicology
    • Place of Presentation
      COEX Convention Center（韓国ソウル）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] グルタチオン依存的 S-トランスアリール化反応は Keap1へのtert-ブチルベンゾキノンによる化学修飾を制御する.2013
    • Author(s)
      安孫子ユミ、熊谷嘉人
    • Organizer
      フォーラム2013：衛生薬学・環境トキシコロジー
    • Place of Presentation
      九州大学医学部百年講堂（福岡県福岡市）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Coriandrum sativum L.葉抽出物に含有される脂肪族親電子物質による無機三価ヒ素の細胞毒性軽減.2013
    • Author(s)
      安孫子ユミ、溝川真衣、熊谷嘉人
    • Organizer
      第19回ヒ素シンポジウム
    • Place of Presentation
      九州大学コラボステーション
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] メチル水銀の解毒を制御するタンパク質由来活性イオウ分子のプロテオミクス.2013
    • Author(s)
      吉田映子、熊谷嘉人
    • Organizer
      フォーラム2013：衛生薬学・環境トキシコロジー
    • Place of Presentation
      九州大学医学部百年講堂（福岡県福岡市）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Removal of 2-tert-butyl-1,4-benzoquinone from Keap1-TBQ adduct by glutathione-mediated S-transarylation.2013
    • Author(s)
      Abiko Y, Kumagai Y.
    • Organizer
      The 8th Tsukuba Medical Science Research Meeting
    • Place of Presentation
      つくば国際会議場（茨城県つくば市）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 硫化水素による親電子シグナルと毒性制御.2013
    • Author(s)
      熊谷嘉人
    • Organizer
      第13回日本NO学会学術集会
    • Place of Presentation
      沖縄県医師会館（沖縄県那覇市）
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Adaptive response and detoxification of the environmental electrophile regulated by the Keap1/Nrf2 pathway.2013
    • Author(s)
      Kumagai Y
    • Organizer
      International Conference on Nutrition and Physical Activity in Aging, Obesity and Cancer （NAPA2013）
    • Place of Presentation
      Centara Grand Mirage Beach Resort（Thailand）
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 有機-無機ハイブリッド分子による生体防御系の活性化.2013
    • Author(s)
      藤江智也, 中寛史, 立浪忠志, 山本千夏, 廣岡孝志, 安池修之, 新開泰弘,熊谷嘉人, 内山 真伸, 鍜冶利幸
    • Organizer
      日本薬学会第133 年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-28
    • Data Source
      KAKENHI-PROJECT-23659063

  • [Presentation] 1,4ナフトキノンは親電子修飾を介して生存シグナル制御に関わるHSF90/HSF1系を活性化する.2013
    • Author(s)
      新開泰弘、沙亮、熊谷嘉人
    • Organizer
      フォーラム2013：衛生薬学・環境トキシコロジー
    • Place of Presentation
      九州大学医学部百年講堂（福岡県福岡市）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] A unique redox signal transduction pathway regulated by reactive sulfur species.2013
    • Author(s)
      Kumagai Y
    • Organizer
      The 2nd Human Biology Symposium
    • Place of Presentation
      つくば国際会議場（茨城県つくば市）
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 環境中親電子リガンドの毒性を制御するH2S/HS-系.2013
    • Author(s)
      新開泰弘、吉田映子、外山喬、石井功、赤池孝章、熊谷嘉人
    • Organizer
      第66回日本酸化ストレス学会学術集会
    • Place of Presentation
      ウインクあいち（愛知県名古屋市）
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 1,4ナフトキノンは親電子修飾を介して生存シグナル制御に関わるHSF90/HSF1系を活性化する2013
    • Author(s)
      新開泰弘、沙亮、熊谷嘉人
    • Organizer
      フォーラム2013：衛生薬学・環境トキシコロジー
    • Place of Presentation
      九州大学医学部百年講堂（福岡県福岡市）
    • Data Source
      KAKENHI-PROJECT-24590159

  • [Presentation] 血管内皮細胞においてビグリカンの発現制御はシンデカン-4の発現を誘導する.2013
    • Author(s)
      原崇人、新開泰弘、山本千夏、熊谷嘉人、鍛冶利幸
    • Organizer
      フォーラム2013：衛生薬学・環境トキシコロジー
    • Place of Presentation
      九州大学医学部百年講堂（福岡県福岡市）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Detoxification of methylmercury by hydrogen sulfide producing enzyme in vitro and in vivo.2013
    • Author(s)
      Yoshida E, Toyama T, Kumagai Y.
    • Organizer
      The 8th Tsukuba Medical Science Research Meeting
    • Place of Presentation
      つくば国際会議場（茨城県つくば市）
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 環境中親電子物質によるタンパク質の化学修飾とそれに対する応答戦略2012
    • Author(s)
      熊谷嘉人
    • Organizer
      第39回日本毒性学会学術年会シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2012-07-19
    • Data Source
      KAKENHI-PROJECT-22406004

  • [Presentation] Negative regulation of CBS to generate hydrogen sulfide on activation of an electrophilic signaling in human epithelial A431 cells.2012
    • Author(s)
      Kumagai Y.
    • Organizer
      The 33rd Naito Conference on Oxygen, Oxidative Stress and Diseases
    • Place of Presentation
      札幌
    • Year and Date
      2012-06-27
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-23117703

  • [Presentation] Invasion of environmental electrophiles into cells, resulting in a modulation of cellular signaltransduction pathways2012
    • Author(s)
      Kumagai Y
    • Organizer
      UK-Japan Research Symposium. Molecular Mechanisms of Stress Response in Disease
    • Place of Presentation
      つくば
    • Year and Date
      2012-04-07
    • Data Source
      KAKENHI-PROJECT-22406004

  • [Presentation] The Keap1-Nrf2 system regulates metallothionein expression and protects vascular endothelial cells from cadmium cytotoxicity2011
    • Author(s)
      Shinkai Y, Kumagai Y, Kimura T, Yamamoto C, Yamamoto M, Jinno H, Tanaka-Kagawa T, Kaji T
    • Organizer
      Society of Toxicology 50th Annual Meeting
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-03-08
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] HepG2細胞においてNrf2/HO-1シグナルの活性化は仁素の毒性の軽減に関与する2011
    • Author(s)
      安孫子ユミ、新開泰弘、角大悟、熊谷嘉人
    • Organizer
      第16回ヒ素シンポジウム
    • Place of Presentation
      旭川市(北海道)
    • Year and Date
      2011-01-06
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 大気親電子物質1, 4-ナフトキノンによるタンパク質の化学修飾を検出する免疫化学的手法の開発2011
    • Author(s)
      広瀬玲子, 三浦高, 新開泰弘, 香川(田中)聡子, 神野透人, 熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      石川県
    • Year and Date
      2011-10-28
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] タンパク質の親電子修飾の制御に働く新奇求核分子としての硫化水素2011
    • Author(s)
      熊谷嘉人
    • Organizer
      第11回日本NO学会学術集会
    • Place of Presentation
      東京都(招待講演)
    • Year and Date
      2011-05-13
    • Data Source
      KAKENHI-PUBLICLY-23117703

  • [Presentation] 親電子物質によるタンパク質の化学修飾と心毒性2011
    • Author(s)
      熊谷嘉人
    • Organizer
      八ヶ岳フォーラム
    • Place of Presentation
      長野県
    • Year and Date
      2011-09-03
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] カドミウムによる親電子物質応答配列を介した転写因子Nrf1の活性化2011
    • Author(s)
      伊藤友里, 新開泰弘, 山本千夏, 鍜冶利幸, 熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      石川県
    • Year and Date
      2011-10-27
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 親電子修飾の自己制御を司る解糖系タンパク質2011
    • Author(s)
      熊谷嘉人
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡県
    • Year and Date
      2011-03-29
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 環境中親電子物質によるタンパク質の化学修飾を制御する細胞内システム.2011
    • Author(s)
      熊谷嘉人
    • Organizer
      九州大学・生体防御医学研究所 共同利用 研究集会(招待講演)
    • Place of Presentation
      九州大学 （福岡県）
    • Data Source
      KAKENHI-PROJECT-23659063

  • [Presentation] メチル水銀によるS-水銀化を介したソルビトール脱水素酵素の機能破綻2011
    • Author(s)
      外山喬士, 神田洋紀, 新開泰弘, 熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      石川県
    • Year and Date
      2011-10-28
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] タンパク質と共有結合する薬毒物の生体反応とそれに対する細胞の防御戦略2011
    • Author(s)
      熊谷嘉人
    • Organizer
      安全性評価研究会セミナー
    • Place of Presentation
      東京都
    • Year and Date
      2011-12-03
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 大気親電子物質1,4-ナフトキノンによるタンパク質の化学修飾を検出する免疫化学的手法の開発2011
    • Author(s)
      広瀬玲子、三浦高、新開泰弘、香川(田中)聡子、神野透人、熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      石川県
    • Year and Date
      2011-10-28
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 環境中親電子物質に対する生体応答およびリスク軽減戦略2011
    • Author(s)
      熊谷嘉人
    • Organizer
      第4回エコファーマシンポジウム
    • Place of Presentation
      熊本市(熊本県)
    • Year and Date
      2011-02-08
    • Data Source
      KAKENHI-PROJECT-21659154

  • [Presentation] Mechanisms by which glyceraldehyde-3-phosphate dehydrogenase protects itself against a chemical modification2011
    • Author(s)
      Miura T, Egara Y, Hirose R, Iwamoto N, Shinkai Y, Jinno H, Tanaka-Kagawa T, Cho AK, Kumagai Y
    • Organizer
      Society of Toxicology 50th Annual Meeting
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-03-08
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 環境中親電子物質に対する生体応答およびリスク軽減戦略.2011
    • Author(s)
      熊谷嘉人
    • Organizer
      第4回エコファーマシンポジウム
    • Place of Presentation
      熊本市(熊本県)
    • Year and Date
      2011-02-08
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 環境中親電子物質の活性制御を担う硫化水素2011
    • Author(s)
      熊谷嘉人
    • Organizer
      第64回日本酸化ストレス学会学術集会
    • Place of Presentation
      北海道(招待講演)
    • Year and Date
      2011-07-03
    • Data Source
      KAKENHI-PUBLICLY-23117703

  • [Presentation] Detoxification of an environmental electrophile by hydrogen sulfide : a function as a nucleophilic molecule2011
    • Author(s)
      Kumagai Y
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都府(招待講演)
    • Year and Date
      2011-09-21
    • Data Source
      KAKENHI-PUBLICLY-23117703

  • [Presentation] タンパク質と共有結合する薬毒物の生体反応とそれに対する細胞の防御戦略.2011
    • Author(s)
      熊谷嘉人
    • Organizer
      安全性評価研究会セミナー(招待講演)
    • Place of Presentation
      明治製菓ビル（東京都）
    • Data Source
      KAKENHI-PROJECT-23659063

  • [Presentation] グルタチオンの新たな機能:大気中親電子物質による細胞内タンパク質の化学修飾制御に係わるS-トランスアリール化2011
    • Author(s)
      三浦高, 掛橋秀直, 新開泰弘, 熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      石川県
    • Year and Date
      2011-10-27
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 環境中親電子物質に対する生体応答およびリスク軽減戦略2011
    • Author(s)
      熊谷嘉人.
    • Organizer
      第4回エコファーマシンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      2011-02-08
    • Data Source
      KAKENHI-PROJECT-22406004

  • [Presentation] Keap1/Nrf2システムを介したメチル水銀に対する生体応答・毒性防御2011
    • Author(s)
      熊谷嘉人, 外山喬士, 新開泰弘, 角大悟, 山本雅之
    • Organizer
      第10回分子予防環境医学研究会
    • Place of Presentation
      京都府
    • Year and Date
      2011-01-21
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 環境中親電子物質によるタンパク質の化学修飾を制御する細胞内システム2011
    • Author(s)
      熊谷嘉人
    • Organizer
      九州大学・生体防御医学研究所共同利用研究集会
    • Place of Presentation
      福岡県
    • Year and Date
      2011-07-22
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] HepG2細胞においてNrf2/HO-1シグナルの活性化はヒ素の毒性の軽減に関与する2011
    • Author(s)
      安孫子ユミ, 新開泰弘, 角大悟, 熊谷嘉人
    • Organizer
      第16回ヒ素シンポジウム
    • Place of Presentation
      北海道
    • Year and Date
      2011-02-05
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] ヒ素の感知・応答センサーおよびリスク軽減因子としてのKeap1/Nrf2システム.2011
    • Author(s)
      熊谷嘉人
    • Organizer
      第16回ヒ素シンポジウム
    • Place of Presentation
      旭川市
    • Year and Date
      2011-01-05
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 大気中親電子物質:タンパク質の化学修飾を介した有害反応とそれに対する生体側の防御戦略2011
    • Author(s)
      熊谷嘉人
    • Organizer
      日本自動車研究所講演会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-25
    • Data Source
      KAKENHI-PROJECT-22406004

  • [Presentation] ヒ素の感知・応答センサーおよびリスク軽減因子としてのKeap1/Nrf2システム2011
    • Author(s)
      熊谷嘉人
    • Organizer
      第16回ヒ素シンポジウム
    • Place of Presentation
      北海道
    • Year and Date
      2011-02-05
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] Keap1/Nrf2システムを介したメチル水銀に対する生体応答・毒性防御2011
    • Author(s)
      熊谷嘉人、外山喬士、新開泰弘、角大悟、山本雅之
    • Organizer
      分子予防環境医学研究会
    • Place of Presentation
      京都市(京都府)
    • Year and Date
      2011-01-21
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 環境中親電子物質によるタンパク質の化学修飾を制御する細胞内システム2011
    • Author(s)
      熊谷嘉人
    • Organizer
      九州大学・生体防御医学研究所 共同利用研究集会
    • Place of Presentation
      福岡(招待講演)
    • Year and Date
      2011-07-22
    • Data Source
      KAKENHI-PROJECT-23659063

  • [Presentation] メチル水銀の解毒防御因子としての硫化水素2011
    • Author(s)
      吉田映子、外山喬士、新開泰弘、熊谷嘉人
    • Organizer
      メタロチオネインおよびメタルバイオサイエンス研究会
    • Place of Presentation
      愛知県
    • Year and Date
      2011-12-09
    • Data Source
      KAKENHI-PUBLICLY-23117703

  • [Presentation] 哺乳類における硫化水素産生酵素が係わるメチル水銀の新奇解毒代謝物(MeHg)2S2011
    • Author(s)
      吉田映子、外山喬士、新開泰弘、熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      石川県
    • Year and Date
      2011-10-27
    • Data Source
      KAKENHI-PUBLICLY-23117703

  • [Presentation] A unique protein mediating cellular protection against methylmercury.2011
    • Author(s)
      Kumagai Y
    • Organizer
      NIMD Forum
    • Place of Presentation
      水俣市(熊本県)
    • Year and Date
      2011-01-27
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 環境中親電子物質に対する生体応答およびリスク軽減戦略2011
    • Author(s)
      熊谷嘉人
    • Organizer
      第4回エコファーマシンポジウム
    • Place of Presentation
      熊本県
    • Year and Date
      2011-02-08
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] タンパク質と共有結合する薬毒物の生体反応とそれに対する細胞の防御戦略2011
    • Author(s)
      熊谷嘉人
    • Organizer
      安全性評価研究会セミナー
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-12-03
    • Data Source
      KAKENHI-PROJECT-23659063

  • [Presentation] ブチルヒドロキシアニソールで生じるNrf2活性化はその親電子代謝物によるKeap1の化学修飾が関与する2011
    • Author(s)
      安孫子ユミ, 岩本典子, Bui Hoang Phuc, 新開泰弘, 熊谷嘉人
    • Organizer
      第38回日本トキシコロジー学会学術集会
    • Place of Presentation
      神奈川県
    • Year and Date
      2011-07-11
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 環境中親電子物質に対する生体応答およびリスク軽減戦略2011
    • Author(s)
      熊谷嘉人
    • Organizer
      第4回エコファーマシンポジウム2011年
    • Place of Presentation
      熊本市(熊本県)
    • Year and Date
      2011-02-08
    • Data Source
      KAKENHI-PUBLICLY-21117504

  • [Presentation] アクアポリン9はマウス初代肝細胞においてヒ素の細胞内蓄積とそれに伴う細胞毒性に関与する2011
    • Author(s)
      新開泰弘, 角大悟, 外山喬士, 熊谷嘉人
    • Organizer
      第17回ヒ素シンポジウム
    • Place of Presentation
      茨城県
    • Year and Date
      2011-11-19
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] ブチルヒトロキシアニソールの親電子代謝物による芳香族炭化水素受容体の活性化2011
    • Author(s)
      安孫子ユミ, 熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      石川県
    • Year and Date
      2011-10-27
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 環境中親電子物質に対する生体応答およびリスク軽減戦略2011
    • Author(s)
      熊谷嘉人
    • Organizer
      第4回エコファーマシンポジウム
    • Place of Presentation
      熊本県(熊本市)
    • Year and Date
      2011-02-08
    • Data Source
      KAKENHI-PROJECT-22406004

  • [Presentation] タンパク質と共有結合する薬毒物の生体反応とそれに対する細胞の防御戦略2011
    • Author(s)
      熊谷嘉人
    • Organizer
      安全性評価研究会セミナー
    • Place of Presentation
      東京都(招待講演)
    • Year and Date
      2011-12-03
    • Data Source
      KAKENHI-PUBLICLY-23117703

  • [Presentation] 生体内親電子性代謝物ニトロ化オレイン酸はPTP1Bの活性を阻害しEGFRシグナル伝達経路を活性化する2010
    • Author(s)
      岩本典子、Bruce A Freeman、熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      品川区(東京都)
    • Year and Date
      2010-09-09
    • Data Source
      KAKENHI-PUBLICLY-21117504

  • [Presentation] イオウ原子を利用したメチル水銀に対する生体の防御戦略2010
    • Author(s)
      熊谷嘉人
    • Organizer
      北陸大学学術フロンティア・サテライトミーティング
    • Place of Presentation
      熊本県
    • Year and Date
      2010-02-19
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 血管内皮細胞において鉛はJNK-AP-1経路を介して小胞体シャペロンGRP78およびGRP94を誘導する2010
    • Author(s)
      新開泰弘, 山本千夏, 鍜冶利幸, 熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      東京都
    • Year and Date
      2010-09-10
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] ブチルヒドロキシアニソールの親電子代謝物によるKeap1/Nrf2システムの活性化2010
    • Author(s)
      安孫子ユミ Bui Hoang Phuc, 岩本典子, 新開泰弘, 熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      品川区(東京都)
    • Year and Date
      2010-09-10
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] S-トランスアルキル化を介した親電子修飾の自己制御タンパク質の同定2010
    • Author(s)
      矢澤亜季、岩本典子、安孫子ユミ、浅井聡、三浦高、新開泰弘、熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      品川区(東京都)
    • Year and Date
      2010-09-09
    • Data Source
      KAKENHI-PUBLICLY-21117504

  • [Presentation] 環境化学物質によるシステイン残基を介したタンパク質の翻訳後修飾2010
    • Author(s)
      熊谷嘉人
    • Organizer
      日本衛生学会総会シンポジウム
    • Place of Presentation
      仙台市(宮城県)
    • Year and Date
      2010-05-09
    • Data Source
      KAKENHI-PROJECT-21659154

  • [Presentation] メチル水銀の解毒排泄における転写因子Nrf2の役割2010
    • Author(s)
      新開泰弘、外山喬士、安武章、 山本雅之、熊谷嘉人
    • Organizer
      第80回日本衛生学会学術総会
    • Place of Presentation
      仙台市(宮城県)
    • Year and Date
      2010-05-11
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 親電子物質とその制御に係わる細胞内システム2010
    • Author(s)
      熊谷嘉人
    • Organizer
      第27回臨床フリーラジカル会議
    • Place of Presentation
      亀岡市(京都府)
    • Year and Date
      2010-12-04
    • Data Source
      KAKENHI-PUBLICLY-21117504

  • [Presentation] S-トランスアルキル化を介した親電子修飾の自己制御タンパク質の同定2010
    • Author(s)
      矢澤亜季、岩本典子、安孫子ユミ、浅井聡、三浦高、新開泰弘、熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      品川区(東京都)
    • Year and Date
      2010-09-09
    • Data Source
      KAKENHI-PROJECT-21659154

  • [Presentation] 8-Nitro-cGMPによるGAPDHの基質依存的な酸化的不活性化の促進2010
    • Author(s)
      小野勝彦、居原秀、三浦高、岩本典子、澤智裕、熊谷嘉人、赤池孝章
    • Organizer
      第83回日本生化学会大会
    • Place of Presentation
      神戸市(兵庫県)
    • Year and Date
      2010-12-08
    • Data Source
      KAKENHI-PUBLICLY-21117504

  • [Presentation] 血管内皮細胞においてNrf1はカドミウムに対する防御応答を担う転写因子である2010
    • Author(s)
      新開泰弘, 山本千夏, 鍛治利幸, 熊谷嘉人
    • Organizer
      第37回日本トキシコロジー学会学術年会
    • Place of Presentation
      沖縄県
    • Year and Date
      2010-06-17
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] Nrf2-dependent protection against methylmercury toxicity in vitro and in vivo2010
    • Author(s)
      Kumagai Y, Toyama T, Shinkai Y, Yasutake
    • Organizer
      XII International Congress of Toxicology
    • Place of Presentation
      Balcelona, Spain
    • Year and Date
      2010-07-22
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] イオウ原子を利用したメチル水銀に対する生体の防御戦略2010
    • Author(s)
      熊谷嘉人
    • Organizer
      北陸大学学術フロンティアー・サテライトミーティング
    • Place of Presentation
      水俣
    • Year and Date
      2010-02-19
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] Activation of EGFR coupled to reduction of PTP1B activity by nitratedoleic acid : an electrophile signaling.2010
    • Author(s)
      Iwamoto N, Akaike T, BA Freeman, Kumagai Y
    • Organizer
      The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      京都市(京都府)
    • Year and Date
      2010-06-14
    • Data Source
      KAKENHI-PUBLICLY-21117504

  • [Presentation] ブチルヒドロキシアニソールの親電子代謝物によるKeap1/Nrf2システムの活性化2010
    • Author(s)
      安孫子ユミ, Bui Hoang Phuc, 岩本典子, 新開泰弘, 熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      東京都
    • Year and Date
      2010-09-10
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 血管内皮細胞において鉛はJNK-AP-1経路を介して小胞体シャペロンGRP78およびGRP94を誘導する2010
    • Author(s)
      新開泰弘、山本千夏、鍛冶利幸、熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      品川区(東京都)
    • Year and Date
      2010-09-10
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 血管内皮細胞においてNrflはカドミウムに対する防御応答を担う転写因子である2010
    • Author(s)
      新開泰弘、山本千夏、鍛治利幸、熊谷嘉人
    • Organizer
      第37回日本トキシコロジー学会学術年会
    • Place of Presentation
      宜野湾市(沖縄県)
    • Year and Date
      2010-06-17
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] Glyceraldehyde 3-phosphate dehydrogenaseの基質依存的な酸化的不活性化2010
    • Author(s)
      小野勝彦、居原秀、三浦高、岩本典子、熊谷嘉人、澤智裕、赤池孝章
    • Organizer
      第63回日本酸化ストレス学会学術集会
    • Place of Presentation
      横浜市(神奈川県)
    • Year and Date
      2010-06-24
    • Data Source
      KAKENHI-PUBLICLY-21117504

  • [Presentation] 環境化学物質によるシステイン残基を介したタンパク質の翻訳後修飾2010
    • Author(s)
      熊谷嘉人
    • Organizer
      日本衛生学会総会シンポジウム
    • Place of Presentation
      仙台市(宮城県)
    • Year and Date
      2010-05-09
    • Data Source
      KAKENHI-PUBLICLY-21117504

  • [Presentation] 親電子修飾の自己制御能を有する解糖系酵素としてのグリセルアルデヒド3-リン酸脱水素酵素2010
    • Author(s)
      三浦高、岩本典子、新開泰弘、熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      品川区(東京都)
    • Year and Date
      2010-09-09
    • Data Source
      KAKENHI-PROJECT-21659154

  • [Presentation] 親電子修飾の自己制御能を有する解糖系酵素としてのグリセルアルデヒド3-リン酸脱水素酵素2010
    • Author(s)
      三浦高、岩本典子、新開泰弘、熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      品川区(東京都)
    • Year and Date
      2010-09-09
    • Data Source
      KAKENHI-PUBLICLY-21117504

  • [Presentation] メチル水銀の解毒排泄における転写因子Nrf2の役割2010
    • Author(s)
      新開泰弘, 外山喬士, 安武章, 山本雅之, 熊谷嘉人
    • Organizer
      第80回日本衛生学会学術総会
    • Place of Presentation
      宮城県
    • Year and Date
      2010-05-11
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] S-トランスアルキル化を介した親電子修飾の自己制御タンパク質の同定2010
    • Author(s)
      矢澤亜季, 岩本典子, 安孫子ユミ, 浅井聡, 三浦高, 新開泰弘, 熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      東京都
    • Year and Date
      2010-09-10
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] Nrf2-dependent protection' against methylmercury toxicity in vitro and in vivo.2010
    • Author(s)
      Kumagai Y, Toyama T, ShinkaiY, Yasutake
    • Organizer
      XII International Congress of Toxicology
    • Place of Presentation
      バルセロナ(スペイン)
    • Year and Date
      2010-07-22
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 親電子修飾の自己制御能を有する解糖系酵素としてのグリセルアルデヒド3-リン酸脱水素酵素2010
    • Author(s)
      三浦高, 岩本典子, 新開泰弘, 熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      東京都
    • Year and Date
      2010-09-09
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 親電子物質とその制御に係わる細胞内システム2010
    • Author(s)
      熊谷嘉人
    • Organizer
      第27回臨床フリーラジカル会議
    • Place of Presentation
      亀岡市(京都府)
    • Year and Date
      2010-12-04
    • Data Source
      KAKENHI-PROJECT-21659154

  • [Presentation] 環境化学物質によるシステイン残基を介したタンパク質の翻訳後修飾.2010
    • Author(s)
      熊谷嘉人
    • Organizer
      日本衛生学会総会シンポジウム
    • Place of Presentation
      仙台市
    • Year and Date
      2010-05-09
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 親電子修飾の自己制御能を有する解糖系酵素としてのグリセルアルデヒド3-リン酸脱水素酵素2010
    • Author(s)
      三浦高、岩本典子、新開泰弘、熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      品川区(東京都)
    • Year and Date
      2010-09-09
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 親電子物質とその制御に係わる細胞内システム2010
    • Author(s)
      熊谷嘉人
    • Organizer
      第27回臨床フリーラジカル会議
    • Place of Presentation
      京都府
    • Year and Date
      2010-12-04
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 環境化学物質によるシステイン残基を介したタンパク質の翻訳後修飾2010
    • Author(s)
      熊谷嘉人
    • Organizer
      日本衛生学会総会シンポジウム
    • Place of Presentation
      宮城県
    • Year and Date
      2010-05-09
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 大気中親電子物質によるレドックスセンサーの翻訳後修飾.フォーラム20092009
    • Author(s)
      熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジーシンポジウム
    • Place of Presentation
      沖縄県
    • Year and Date
      2009-11-06
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 親電子物質による翻訳後修飾とそれを制御する因子2009
    • Author(s)
      熊谷嘉人
    • Organizer
      大阪大学蛋白質研究所セミナー「活性酸素のシグナル伝達」
    • Place of Presentation
      大阪
    • Year and Date
      2009-11-27
    • Data Source
      KAKENHI-PROJECT-21659154

  • [Presentation] Cellular proteins regulating electrophile signaling2009
    • Author(s)
      熊谷嘉人
    • Organizer
      FRR International Free Radical School in Japan
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-03
    • Data Source
      KAKENHI-PUBLICLY-21117504

  • [Presentation] 酸化ストレスおよび化学修飾を生じる環境物質を対象としたフィールドサイエンスと実験科学の融合.2009
    • Author(s)
      熊谷嘉人
    • Organizer
      日本薬学会129年会日本薬学会学術振興賞受賞講演
    • Place of Presentation
      京都市
    • Year and Date
      2009-03-25
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 転写因子Nrf2はメチル水銀のリスク軽減因子である2009
    • Author(s)
      外山喬士, 安武章, 熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      沖縄県
    • Year and Date
      2009-11-05
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] Electrophile-mediated activation of PTP1B/EGFR signaling through post-translational modification of a non-catalytic Cys121 of PTP1B2009
    • Author(s)
      Iwamoto N, Ito S, Kobayashi M, Kumagai Y
    • Organizer
      International Symposium 2009 on Signaling Functions of Reactive Oxygen Species
    • Place of Presentation
      熊本県
    • Year and Date
      2009-07-18
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] Activation of EGFR/PTP1B signaling and cellular protection through Nrf2/Keap1 system during exposure to an atmospheric electrophile2009
    • Author(s)
      Kumagai Y, Iwamoto N
    • Organizer
      The 5th International Congress of Asian Society of Toxicology
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2009-09-10
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 親電子物質による翻訳後修飾とそれを制御する因子2009
    • Author(s)
      熊谷嘉人
    • Organizer
      大阪大学蛋白質研究所セミナー「活性酸素のシグナル伝達」
    • Place of Presentation
      大阪府
    • Year and Date
      2009-11-27
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 親電子物質による翻訳後修飾:親電子シグナルとその制御系2009
    • Author(s)
      熊谷嘉人
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      兵庫県
    • Year and Date
      2009-10-23
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 大気中親電物質によるレドックスセンサーの翻訳後修飾2009
    • Author(s)
      熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      沖縄
    • Year and Date
      2009-11-06
    • Data Source
      KAKENHI-PROJECT-21659154

  • [Presentation] Reduction of arsenic mediated cytotoxicity through Nrf2/HO-1 signaling in HepG2 cells2009
    • Author(s)
      Abiko A, Sumi D, Kumagai Y
    • Organizer
      21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
    • Place of Presentation
      東京都
    • Year and Date
      2009-10-27
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 酸化ストレスを生じる大気中多環芳香族炭化水素2009
    • Author(s)
      熊谷嘉人
    • Organizer
      日本衛生学会総会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-04-01
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 親電子物質による翻訳後修飾:親電子シグナルとその制御系2009
    • Author(s)
      熊谷嘉人
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-23
    • Data Source
      KAKENHI-PUBLICLY-21117504

  • [Presentation] 親電子物質による翻訳後修飾:親電子シグナルとその制御系2009
    • Author(s)
      熊谷嘉人
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-23
    • Data Source
      KAKENHI-PROJECT-21659154

  • [Presentation] 新電子シグナルの制御機構2009
    • Author(s)
      熊谷嘉人
    • Organizer
      第62回日本酸化ストレス学会学術集会シンポジウム
    • Place of Presentation
      福岡県
    • Year and Date
      2009-06-11
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] Activation of EGFR/MEK/ERK/AP-1 signaling caused by 1, 2-naphthoquinone2009
    • Author(s)
      Kumagai Y, Iwamoto N
    • Organizer
      International Symposium 2009 on Signaling Functions of Reactive Oxygen Species
    • Place of Presentation
      熊本県
    • Year and Date
      2009-07-18
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] Regulation of ectrophile signaling and cellular protection through Nrf2/Keap1 system during exposure to an environmental electrophile2009
    • Author(s)
      熊谷嘉人
    • Organizer
      21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
    • Place of Presentation
      東京
    • Year and Date
      2009-10-27
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] Protective role of Nrf2 against methylmercury toxicity2009
    • Author(s)
      Toyama T, Yasutake A, Kumagai Y
    • Organizer
      21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
    • Place of Presentation
      東京都
    • Year and Date
      2009-10-27
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 親電子物質による翻訳後修飾とそれを制御する因子2009
    • Author(s)
      熊谷嘉人
    • Organizer
      大阪大学蛋白質研究所セミナー「活性酸素のシグナル伝達」
    • Place of Presentation
      大阪
    • Year and Date
      2009-11-27
    • Data Source
      KAKENHI-PUBLICLY-21117504

  • [Presentation] 大気中親電子物質によるレドックスセンサーの翻訳後修飾2009
    • Author(s)
      熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      沖縄
    • Year and Date
      2009-11-06
    • Data Source
      KAKENHI-PUBLICLY-21117504

  • [Presentation] 親電子シゲナルの制御機構2009
    • Author(s)
      熊谷嘉人
    • Organizer
      第62回日本酸化ストレス学会学術集会シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2009-06-11
    • Data Source
      KAKENHI-PROJECT-21659154

  • [Presentation] 1, 2-NQのCys121修飾によるプロテインチロシンホスファターゼ1B(PTP1B)の構造および活性への影響2009
    • Author(s)
      岩本典子, 伊藤創平, 角大悟, 熊谷嘉人
    • Organizer
      第129年会日本薬学会
    • Place of Presentation
      京都府
    • Year and Date
      2009-03-26
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] Activation of EGFR/MEK/ERK/AP-1 signaling caused by 1, 2-naphthoquin one2009
    • Author(s)
      熊谷嘉人
    • Organizer
      International Symposium 2009 on Signaling Functions of Reactive Oxygen Species
    • Place of Presentation
      熊本
    • Year and Date
      2009-07-18
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 酸化ストレスおよび化学修飾を生じる環境物質を対象としたフィールドサイエンスと実験科学の融合2009
    • Author(s)
      熊谷嘉人
    • Organizer
      日本薬学会129年会日本薬学会学術振興賞受賞講演
    • Place of Presentation
      京都府
    • Year and Date
      2009-03-25
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 大気中揮発相成分はPTP1Bの酸化及び化学修飾を介してEGFR/ERKシグナルを活性化する2009
    • Author(s)
      岩本典子, 中嶋瞬, 熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      沖縄県
    • Year and Date
      2009-11-05
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 1, 2-Naphthoquinone disrupts CREB transcriptional activity through modification of Cys2862009
    • Author(s)
      Endo A, Sumi D, Kumagai Y
    • Organizer
      Society of Toxicology's 48th Annual Meeting
    • Place of Presentation
      Baltimore, USA
    • Year and Date
      2009-03-16
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] Atmospheric electrophiles causing oxidative stress and protein modification. JSPS Asia and Africa Platform Program International Seminar2009
    • Author(s)
      Kumagai Y
    • Organizer
      Environment and Health
    • Place of Presentation
      石川県
    • Year and Date
      2009-10-31
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 転写因子Nrf2によるメチル水銀の毒性軽減.2009
    • Author(s)
      外山喬士, 安武章, 熊谷嘉人
    • Organizer
      メタロチオネインおよびメタルバイオサイエンス研究会
    • Place of Presentation
      東京都
    • Year and Date
      2009-10-17
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] Activation of EGFR/PTP1B signaling and cellular protection through Nrf2/Keap1 system during exposure to an atmospheric electrophile2009
    • Author(s)
      熊谷嘉人
    • Organizer
      The 5th International Congress of Asian Society of Toxicology
    • Place of Presentation
      台湾
    • Year and Date
      2009-09-10
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] HepG2細胞における転写因子Nrf2を介したHO-1によるヒ素の毒性軽減2009
    • Author(s)
      安孫子ユミ, 角大悟, 熊谷嘉人
    • Organizer
      メタロチオネインおよびメタルバイオサイエンス研究会
    • Place of Presentation
      東京都
    • Year and Date
      2009-10-17
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] Atmospheric electrophiles causing oxidative stress and protein modification2009
    • Author(s)
      熊谷嘉人
    • Organizer
      JSPS Asia and Africa Platform Program International Seminar"Environment and Health"
    • Place of Presentation
      金沢
    • Year and Date
      2009-10-31
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 親電子物質による非触媒性Cys121の翻訳後修飾を介したPTP1B/EGFRシグナルの活性化2009
    • Author(s)
      岩本典子, 伊藤創平, 小林麻己人, 熊谷嘉人
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      兵庫県
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] Cellular proteins regulating electrophile signaling2009
    • Author(s)
      熊谷嘉人
    • Organizer
      SERR International Free Radical School in Japan
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-03
    • Data Source
      KAKENHI-PROJECT-21659154

  • [Presentation] Nrf2/Keap1システムを介したヒ素に対する細胞応答・毒性防御戦略2009
    • Author(s)
      熊谷嘉人
    • Organizer
      メタロチオネインおよびメタルバイオサイエンス研究会
    • Place of Presentation
      東京都
    • Year and Date
      2009-10-16
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 親電子物質による翻訳後修飾:親電子シグナルとその制御系.2009
    • Author(s)
      熊谷嘉人
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸市
    • Year and Date
      2009-10-22
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] Reduction of protein tyrosine phosphatase 1B activity caused by electrophiles is accompanied by a conformational alteration following covalent modification of Cys1212009
    • Author(s)
      Iwamoto N, Ito S, Kobayashi M, Kumagai Y
    • Organizer
      21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
    • Place of Presentation
      東京都
    • Year and Date
      2009-10-27
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] Initial response and cellular protection against 1, 2-Naphthoquinone through Nrf2/Keap1 system2009
    • Author(s)
      Miura T, Jiang HY, Nishiyama A, Iwamoto N, Sumi D, Yamamoto M, Kumagai Y
    • Organizer
      21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
    • Place of Presentation
      東京都
    • Year and Date
      2009-10-27
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] Regulation of ectrophile signaling and cellular protection through Nrf2/Keap1 system during exposure to an environmental electrophile2009
    • Author(s)
      Kumagai Y
    • Organizer
      21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
    • Place of Presentation
      東京都
    • Year and Date
      2009-10-27
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 大気中親電子物質によるレドックスセンサーの翻訳後修飾2009
    • Author(s)
      熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      沖縄
    • Year and Date
      2009-11-06
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 大気中親電子性物質とレドックスセンサーの共有結合に起因する細胞内シグナル伝達の撹乱2008
    • Author(s)
      熊谷嘉人
    • Organizer
      日本衛生学会総会(シンポジウム)
    • Place of Presentation
      熊本
    • Year and Date
      2008-03-30
    • Data Source
      KAKENHI-PROJECT-19406003

  • [Presentation] タンパク質に共有結合する環境化学物質の生体応答システム2008
    • Author(s)
      熊谷嘉人
    • Organizer
      日本衛生学会総会シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      2008-03-29
    • Data Source
      KAKENHI-PROJECT-18256005

  • [Presentation] 環境化学物質によるタンパク質の翻訳後修飾 : 毒性発現機構の解明に向けた修飾タンパク質の検出とその構造解析2008
    • Author(s)
      石井剛志、岩本典子、熊谷嘉人
    • Organizer
      第78回日本衛生学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2008-03-29
    • Data Source
      KAKENHI-PROJECT-18406003

  • [Presentation] 1, 2-ナフトキノンはCys286を介して転写因子CREBに共有結合しその機能を阻害する2008
    • Author(s)
      遠藤亜希子, 角大悟, 岩本典子, 熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      熊本県
    • Year and Date
      2008-10-18
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 大気中に含まれる未知の親電子性物質とそれに対する生体応答を評価するシステムの構築2008
    • Author(s)
      西山彰、岩本典子、外山喬士、角大悟、熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      熊本
    • Year and Date
      2008-10-18
    • Data Source
      KAKENHI-PROJECT-18406003

  • [Presentation] 1, 2-ナフトキノンによるプロテインチロシンホスファターゼ1Bの活性阻害におけるCys121の役割2008
    • Author(s)
      岩本典子, 角大悟, 熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      熊本県
    • Year and Date
      2008-10-18
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] カドミウムの毒性防御の細胞応答システムを担う転写因子Nrf22008
    • Author(s)
      新開泰弘, 山本千夏, 熊谷嘉人, 山本雅之, 鍛冶利幸
    • Organizer
      第35回日本トキシコロジー学会学術年会
    • Place of Presentation
      東京都
    • Year and Date
      2008-06-26
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] メチル水銀の分子標的と細胞応答システム.2008
    • Author(s)
      熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      熊本市
    • Year and Date
      2008-10-17
    • Data Source
      KAKENHI-PROJECT-20241015

  • [Presentation] 酸化ストレスを生じる1, 2-ナフトキノンの分子標的としてのチオレドキシン2007
    • Author(s)
      岩本典子、角大悟、石井剛志、内田浩二、中村肇、淀井淳司、熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      大阪
    • Year and Date
      2007-11-01
    • Data Source
      KAKENHI-PROJECT-18406003

  • [Presentation] 大気中微小粒子成分によるERK1/2シグナル伝達経路の活性化2007
    • Author(s)
      岩本典子、張璧伊、角大悟、熊谷嘉人
    • Organizer
      第34回日本トキシコロジー学会 学術年会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-27
    • Data Source
      KAKENHI-PROJECT-18406003

  • [Presentation] 1, 2-ナフトキノンの解毒に関わるNrf2/Keap1システムの役割2007
    • Author(s)
      姜海燕、角大悟、田口恵子、Kit I. Tong、山本雅之、熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      大阪
    • Year and Date
      2007-11-02
    • Data Source
      KAKENHI-PROJECT-18406003

  • [Presentation] Sticky pollutants: chemical knockdown of redox sensors.2007
    • Author(s)
      Kumagai Y, et. al.
    • Organizer
      The 2nd JST-ERATO Yamamoto Environmental Response Project International Symposium
    • Place of Presentation
      つくば(つくば国際会議場)
    • Year and Date
      2007-12-21
    • Data Source
      KAKENHI-PROJECT-18659167

  • [Presentation] 大気中親電子性物質によるPTP1B修飾に伴うEGFRリン酸化.2007
    • Author(s)
      熊谷嘉人, 他
    • Organizer
      第7回分子予防環境医学研究会
    • Place of Presentation
      北九州
    • Year and Date
      2007-10-26
    • Data Source
      KAKENHI-PROJECT-18406003

  • [Presentation] 芳香族炭化水素キノン体によるPTP1Bの化学修飾とそれに伴うEGFRのリン酸化.2007
    • Author(s)
      熊谷嘉人, 他
    • Organizer
      北陸大学学術フロンティア・サテライトミーティング
    • Place of Presentation
      岐阜(ぎふ長良川ホテルパーク)
    • Year and Date
      2007-07-27
    • Data Source
      KAKENHI-PROJECT-18659167

  • [Presentation] 芳香族炭化水素キノン体によるPTF1Bの化学修飾とそれに伴うEGFRのリン酸化.2007
    • Author(s)
      熊谷嘉人, 他
    • Organizer
      北陸大学学術フロンティア・サテライトミーティング
    • Place of Presentation
      岐阜
    • Year and Date
      2007-07-27
    • Data Source
      KAKENHI-PROJECT-18406003

  • [Presentation] 大気中親電子性物質によるPTP1B修飾に伴うEGFRリン酸化.2007
    • Author(s)
      熊谷嘉人, 他
    • Organizer
      第7回分子予防環境医学研究会
    • Place of Presentation
      北九州(西日本総合展示場)
    • Year and Date
      2007-10-26
    • Data Source
      KAKENHI-PROJECT-18659167

  • [Presentation] 大気中親電子性物質によるPTP1B修飾に伴うEGFRリン酸化2007
    • Author(s)
      熊谷嘉人、岩本典子、角大悟
    • Organizer
      第7回分子予防環境医学研究会
    • Place of Presentation
      福岡
    • Year and Date
      2007-10-26
    • Data Source
      KAKENHI-PROJECT-18406003

  • [Presentation] Sticky pollutants: chemical knockdown of redox sensors.2007
    • Author(s)
      Kumagai Y, et. al.
    • Organizer
      The 2nd JST-ERATO Yamamoto Environmental Response Project International Symposium
    • Place of Presentation
      つくば
    • Year and Date
      2007-12-21
    • Data Source
      KAKENHI-PROJECT-18406003

  • [Presentation] Sticky pollutants: chemical knockdown of redox sensors2007
    • Author(s)
      Y. Kumagai
    • Organizer
      The 2nd JST-ERATO Yamamoto Environmental Response Project International Symposium
    • Place of Presentation
      Tsukuba, Japan
    • Year and Date
      2007-12-21
    • Data Source
      KAKENHI-PROJECT-19406003

  • [Presentation] 大気汚染物質のケミカルバイオロジー(その4) : ナフタレンの活性代謝物1, 2-ナフトキノンと共有結合する細胞内タンパク質を検出する免疫化学的方法2006
    • Author(s)
      三浦高、岩本典子、新開泰弘、角大悟、早川和一、熊谷嘉人
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      東京
    • Year and Date
      2006-10-30
    • Data Source
      KAKENHI-PROJECT-18406003

  • [Presentation] Role of reactive sulfur species in detoxification of methylmercury: Phase zero reaction for electrophile trapping and detoxification.
    • Author(s)
      Kumagai Y, Yoshida E, Shinkai Y, Fukuto JM, Akaike T.
    • Organizer
      8th International Nitric Oxide Conference & 6th International Nitrite/Nitrate Conference
    • Place of Presentation
      Cleveland, USA
    • Year and Date
      2014-06-16 – 2014-06-20
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Bismethylmercury sulfideアッセイを用いた活性イオウ分子を分子内に有するタンパク質の同定.
    • Author(s)
      熊谷嘉人、吉田映子、新開泰弘、石井功、赤池孝章.
    • Organizer
      第14回日本NO学会学術集会
    • Place of Presentation
      ホテルニューオータニ佐賀（佐賀県・佐賀市）
    • Year and Date
      2014-05-16 – 2014-05-17
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 環境中親電子物質によるタンパク質の化学修飾とそれに対する応答戦略.
    • Author(s)
      熊谷嘉人
    • Organizer
      第39回日本毒性学会学術年会シンポジウム
    • Place of Presentation
      仙台
    • Invited
    • Data Source
      KAKENHI-PROJECT-22406004

  • [Presentation] Reactive sulfur species-mediated activation of the Keap1-Nrf2 pathway by 1,2-napthoquinone through sulfenic acids formation under oxidative stress.
    • Author(s)
      Shinkai Y, Miura T, Kakehashi H, Akaike T, Kumagai Y.
    • Organizer
      Society of Toxicology 54th Annual Meeting
    • Place of Presentation
      San Diego, United States
    • Year and Date
      2015-03-21 – 2015-03-26
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Reactive sulfur species-mediated activation of the Keap1-Nrf2 pathway by Generation and Action of Reactive.
    • Author(s)
      Kumagai Y.
    • Organizer
      Society for Free Radical Biology and Medicine's 21st Annual Meeting
    • Place of Presentation
      Seattle, United States
    • Year and Date
      2014-11-19 – 2014-11-23
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 転写因子Nrf2の活性化を生じるCoriandrum sativum L.葉抽出物に含有される脂肪族親電子物質の実態解明.
    • Author(s)
      安孫子ユミ、溝河真衣、熊谷嘉人.
    • Organizer
      第41回日本毒性学会学術年会
    • Place of Presentation
      神戸コンベンションセンター（兵庫県・神戸市）
    • Year and Date
      2014-07-02 – 2014-07-04
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Sulfur adducts formation during interaction of nitro-oleic acid with polysulfides.
    • Author(s)
      Kumagai Y, Shinkai Y, Schopfer F. J., Akaike T, Freeman B. A.
    • Organizer
      The 2015 Nitric Oxide Gordon Research Conference
    • Place of Presentation
      Ventura, United States
    • Year and Date
      2015-02-15 – 2015-02-20
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 活性イオウ分子と酸化ストレスを介した 1,2-ナフトキノンによる親電子シグナルの活性化
    • Author(s)
      新開泰弘、三浦高、掛橋秀直、赤池孝章、熊谷嘉人
    • Organizer
      フォーラム2014：衛生薬学・環境トキシコロジー
    • Place of Presentation
      つくば国際会議場（茨城県つくば市）
    • Year and Date
      2014-09-19 – 2014-09-20
    • Data Source
      KAKENHI-PROJECT-24590159

  • [Presentation] Activation of PTP1B/EGFR signal transduction pathway mediated by environmental electrophiles.
    • Author(s)
      Kumagai Y
    • Organizer
      2014 Spring Annual Convention of Pharmaceutical Society of Korea
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2014-04-17 – 2014-04-18
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Invasion of environmental electrophiles into cells, resulting in a modulation of cellular signal transduction pathways. U
    • Author(s)
      Kumagai Y
    • Organizer
      K-Japan Research Symposium. Molecular Mechanisms of Stress Response in Disease
    • Place of Presentation
      つくば
    • Invited
    • Data Source
      KAKENHI-PROJECT-22406004

  • [Presentation] Suppression of arsenite-induced cytotoxicity and activation of Nrf2 by aliphatic electrophiles from Coriandrum sativum L. leaf extract in HepG2 cells.
    • Author(s)
      Abiko Y, Mizokawa M, Kumagai Y.
    • Organizer
      Society of Toxicology 54th Annual Meeting
    • Place of Presentation
      San Diego, United States
    • Year and Date
      2015-03-21 – 2015-03-26
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Reactive sulfur species-mediated activation of the Keap1-Nrf2 pathway by 1,2-napthoquinone through sulfenic acids formation under oxidative stress
    • Author(s)
      Yasuhiro Shinkai, Takashi Miura, Hidenao Kakehashi, Takaaki Akaike, Yoshito Kumagai
    • Organizer
      Society of Toxicology 54th Annual Meeting
    • Place of Presentation
      San Diego Convention Center（San Diego, USA)
    • Year and Date
      2015-03-22 – 2015-03-26
    • Data Source
      KAKENHI-PROJECT-24590159

  • [Presentation] 環境中親電子物質の化学修飾を介したレドックスシグナル伝達変動とそれを制御する活性イオウ分子.
    • Author(s)
      熊谷嘉人
    • Organizer
      第14回分子予防環境医学研究会大会
    • Place of Presentation
      大阪市立大学（大阪府・大阪市）
    • Year and Date
      2015-02-13 – 2015-02-14
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Corianderum sativum L.葉抽出液に含有される脂肪族親電子物質によるシグナル伝達の変動 その1：Keap1/Nrf2 システムの活性化と脂肪族親電子物質の同定.
    • Author(s)
      安孫子ユミ、溝河真衣、里見綾香、熊谷嘉人.
    • Organizer
      第14回分子予防環境医学研究会大会
    • Place of Presentation
      大阪市立大学（大阪府・大阪市）
    • Year and Date
      2015-02-13 – 2015-02-14
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 8-ニトロ-cGMPによる新規タンパク質翻訳後修飾poly-S-グアニル化の検出法の確立．
    • Author(s)
      赤司壮一郎、Jung Minkyung、松永哲郎、井田智章、藤井重元、澤智裕、熊谷嘉人、赤池孝章.
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館（京都府・京都市）
    • Year and Date
      2014-10-15 – 2014-10-18
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] Corianderum sativum L.葉抽出液に含有される脂肪族親電子物質によるシグナル伝達の変動 その2：ヒ素の細胞毒性軽減と炎症シグナル抑制作用.
    • Author(s)
      里見綾香、安孫子ユミ、溝河真衣、熊谷嘉人.
    • Organizer
      第14回分子予防環境医学研究会大会
    • Place of Presentation
      大阪市立大学（大阪府・大阪市）
    • Year and Date
      2015-02-13 – 2015-02-14
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 活性イオウ分子と活性酸素種が介在する可逆的な親電子シグナルの活性化
    • Author(s)
      新開泰弘、三浦高、掛橋秀直、赤池孝章、熊谷嘉人
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館（京都府京都市）
    • Year and Date
      2014-10-15 – 2014-10-18
    • Data Source
      KAKENHI-PROJECT-24590159

  • [Presentation] 活性システインパーサルファイドとS-ポリチオレーションが酸化ストレスを制御する．
    • Author(s)
      井田智章、澤智裕、居原秀、土屋幸弘、渡邊泰男、熊谷嘉人、末松誠、本橋ほづみ、藤井重元、松永哲郎、山本雅之、Xian Ming、Fukuto Jon、赤池孝章.
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館（京都府・京都市）
    • Year and Date
      2014-10-15 – 2014-10-18
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] HepG2細胞における Coriandrum sativum L. 葉抽出液中の脂肪族親電子物質による無機三価ヒ素細胞毒性の軽減.
    • Author(s)
      安孫子ユミ、溝川真衣、熊谷嘉人.
    • Organizer
      フォーラム2014　衛生薬学・環境トキシコロジー
    • Place of Presentation
      つくば国際会議場（茨城県・つくば市）
    • Year and Date
      2014-09-19 – 2014-09-20
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 活性イオウ分子と活性酸素種が介在する可逆的な親電子シグナルの活性化.
    • Author(s)
      新開泰弘、三浦高、掛橋秀直、赤池孝章、熊谷嘉人.
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館（京都府・京都市）
    • Year and Date
      2014-10-15 – 2014-10-18
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] メチル水銀による心臓リスク増大の分子メカニズム.
    • Author(s)
      外山喬士、熊谷嘉人、鍜冶利幸、赤池孝章、西田基宏.
    • Organizer
      フォーラム2014　衛生薬学・環境トキシコロジー
    • Place of Presentation
      つくば国際会議場（茨城県・つくば市）
    • Year and Date
      2014-09-19 – 2014-09-20
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 活性イオウ分子と酸化ストレスを介した 1,2-ナフトキノンによる親電子シグナルの活性化．
    • Author(s)
      新開泰弘、三浦高、掛橋秀直、赤池孝章、熊谷嘉人.
    • Organizer
      フォーラム2014　衛生薬学・環境トキシコロジー
    • Place of Presentation
      つくば国際会議場（茨城県・つくば市）
    • Year and Date
      2014-09-19 – 2014-09-20
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] メチル水銀とそのグルタチオン抱合体によるKeap1/Nrf2 経路の活性化
    • Author(s)
      新開泰弘、吉田映子、外山喬士、熊谷嘉人
    • Organizer
      平成25年度メチル水銀研究ミーティング
    • Place of Presentation
      LMJ東京研修センター（東京都文京区）
    • Data Source
      KAKENHI-PROJECT-24590159

  • [Presentation] メチル水銀によるタンパク質のS-水銀化を制御する活性イオウ分子.
    • Author(s)
      熊谷嘉人
    • Organizer
      第41回日本毒性学会学術年会
    • Place of Presentation
      神戸コンベンションセンター（兵庫県・神戸市）
    • Year and Date
      2014-07-02 – 2014-07-04
    • Invited
    • Data Source
      KAKENHI-PROJECT-25220103

  • [Presentation] 第41回日本毒性学会学術年会
    • Author(s)
      新開泰弘、吉田映子、Bruce A. FREEMAN、西田基宏、澤 智裕、赤池孝章、熊谷嘉人
    • Organizer
      神戸コンベンションセンター
    • Place of Presentation
      神戸コンベンションセンター（兵庫県神戸市）
    • Year and Date
      2014-07-02 – 2014-07-04
    • Data Source
      KAKENHI-PROJECT-24590159

  • [Presentation] 活性イオウ分子産生酵素シスタチオニンβシンターゼによる親電子シグナル伝達系の制御.
    • Author(s)
      新開泰弘、吉田映子、Bruce A. FREEMAN、西田基宏、澤 智裕、赤池孝章、熊谷嘉人.
    • Organizer
      第41回日本毒性学会学術年会
    • Place of Presentation
      神戸コンベンションセンター（兵庫県・神戸市）
    • Year and Date
      2014-07-02 – 2014-07-04
    • Data Source
      KAKENHI-PROJECT-25220103
  • 1.  TAKANO Hirohisa (60281698)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 12 results
  • 2.  SHIMOJO Nobuhiro (00080622)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 3 results
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    # of Collaborated Products: 50 results
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    # of Collaborated Projects: 5 results
    # of Collaborated Products: 6 results
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    # of Collaborated Products: 82 results
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    # of Collaborated Products: 5 results
  • 7.  YAMANO Shigeru (80140755)
    # of Collaborated Projects: 3 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Products: 5 results
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  • 54.  TAKASUGI Nobumasa