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YAMASHITA Shinji  山下 伸二

ORCIDConnect your ORCID iD *help
Researcher Number 00158156
Other IDs
Affiliation (Current) 2025: 立命館大学, 総合科学技術研究機構, 教授
Affiliation (based on the past Project Information) *help 2009 – 2011: 摂南大学, 薬学部, 教授
2006 – 2007: 摂南大学, 薬学部, 教授
1994 – 1999: SETSUNAN UNIVERSITY,PHARMACY,ASSOCIATE PROFESSOR, 薬学部, 助教授
1993: 摂南大学, 薬学部, 講師
Review Section/Research Field
Principal Investigator
Physical pharmacy / 応用薬理学・医療系薬学
Except Principal Investigator
Physical pharmacy / Medical pharmacy / Physical pharmacy
Keywords
Principal Investigator
消化管吸収 / 経口投与 / Drug Disposition / IgG Antibody / Protein Drugs / Oral Tolerance / Systemic Immune Response / 経口免疫寛溶 / 体内動態 / IgG抗体 … More / 蛋白質医薬品 / 経口免疫寛容 / 全身免疫 / 培養細胞 / 刷子縁膜小胞 / 担体輸送 / 膜透過性 / Caco-2単層膜 / 経口ワクチン / AIDS / 経粘膜感染 / 経口感作 / IgA抗体 / 局所免疫 / liposome / リンパ移行 / 鼻腔内投与 / ovalbumin / 初回通過代謝 / 代謝阻害 / bioavailability / エンケファリン … More
Except Principal Investigator
Nanomedicine / Lectin / Imaging agent / Endoscopy / Colorectal cancer / ナノメディシン / レクチン / 造影剤 / 内視鏡 / 大腸癌 / absorption enhancer / retention in skin tissue / transdermal delivery preparations / percutaneous absorption / microdialysis / 皮膚内滞菌性 / 吸収促進剤 / 皮膚内滞留性 / 経皮適用製剤 / 経皮吸収 / マイクロダイアリシス / peptide drug / pharmacokinetic model / cultured human cell line / intestinal perfusion / drug absorption / oral administration / 薬物吸収モデル / Caco-2単層膜 / 膜透過性 / 酵素阻害剤 / 吸収速度定数 / ペプチド性医薬品 / 薬動学的モデル / ヒト培養細胞 / 消化管灌流法 / 薬物吸収 / 経口投与 / 糖鎖 / 消化管 / GLP-1 / SGLT1 / デンドリマー / インクレチン / ヘキソーストランスポーター / 糖尿病 / 配糖体 / 高分子複合体 Less
  • Research Projects

    (9 results)
  • Research Products

    (8 results)
  • Co-Researchers

    (10 People)
  •  Manipulation of gastrointestinal functions by polymeric conjugates bearing glucosides, oral anti-diabetic drugs

    • Principal Investigator
      SAKUMA Shinji
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Setsunan University
  •  Study on diagnosis and treatment of cancer in the gastrointestine using cancer-recognizable nanocarriers

    • Principal Investigator
      SAKUMA Shinji
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Setsunan University
  •  Use of Oral Tolerance to Improve the Disposition of Protein Drugs in the BodyPrincipal Investigator

    • Principal Investigator
      YAMASHITA Shinji
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Setsunan University
  •  Evaluation of bases for topical preparations by microdialysis

    • Principal Investigator
      YATA Noboru
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Setsunan University
  •  培養細胞を用いた薬物の消化管吸収スクリーニングシステムの開発Principal Investigator

    • Principal Investigator
      山下 伸二
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Setsunan University
  •  エイズウイルスの性交渉感染予防を目的とした経口ワクチンの開発Principal Investigator

    • Principal Investigator
      山下 伸二
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Setsunan University
  •  高分子薬品の生体内移行性の速度論的解析に基づく新規投与システムの開発Principal Investigator

    • Principal Investigator
      山下 伸二
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Physical pharmacy
    • Research Institution
      Setsunan University
  •  ペプチド性医薬品の消化管での代謝・吸収に関する速度論的研究Principal Investigator

    • Principal Investigator
      山下 伸二
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Physical pharmacy
    • Research Institution
      Setsunan University
  •  PREDICTION AND OPTIMIZATION OF DRUG ABSORPTION FROM THE GASTRO-INTESTINAL TRACT

    • Principal Investigator
      SEZAKI Hitoshi
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      SETSUNAN UNIVERSITY

All 2012 2011 2010 2009 Other

All Journal Article Presentation

  • [Journal Article] Carboxyl group-terminated polyamidoamine dendrimers bearing glucosides inhibit intestinal hexose transporter-mediated D-glucose uptake2010

    • Author(s)
      Shinji Sakuma, Yumi Teraoka, Tomokazu Sagawa, Yoshie Masaoka, Makoto Kataoka, Shinji Yamashita, Yoshiyuki Shirasaka, Ikumi Tamai, Yusuke Ikumi, Toshiyuki Kida, Mitsuru Akashi
    • Journal Title

      Eur. J. Pharm. Biopharm

      Volume: 75(3) Pages: 366-374

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590051
  • [Journal Article] Involvement of functional groups on the surface of carboxyl group-terminated polyamidoamine dendrimers bearing arbutin in inhibition of Na+/glucose cotransporter 1(SGLT1)-mediated D-glucose uptake

    • Author(s)
      Shinji Sakuma, Shun Kanamitsu, Yumi Teraoka, Yoshie Masaoka, Makoto Kataoka, Shinji Yamashita, Yoshiyuki Shirasaka, Ikumi Tamai, Masahiro Muraoka, Yohji Nakatsuji, Toshiyuki Kida, Mitsuru Akashi
    • Journal Title

      Mol. Pharmaceutics

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590051
  • [Presentation] 消化管膜機能制御に基づく抗糖尿病作用を有する配糖体-高分子複合体の精密設計2012

    • Author(s)
      佐久間信至, 金光俊, 寺岡裕美, 政岡祥江, 片岡誠, 山下伸二, 白坂善之, 玉井郁巳, 村岡雅弘, 中辻洋司, 木田敏之, 明石満
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-30
    • Data Source
      KAKENHI-PROJECT-21590051
  • [Presentation] Inhibitory effect of arbutin conjugated to polyamidoamine dendrimers on intestinal glucose transport2011

    • Author(s)
      Shun Kanamitsu, Shinji Sakuma, Yumi Teraoka, Yoshie Masaoka, Makoto Kataoka, Shinji Yamashita, Yoshiyuki Shirasaka, Ikumi Tamai, Masahiro Muraoka, Yohji Nakatsuji, Toshiyuki Kida, Mitsuru Akashi
    • Organizer
      International Symposium on BA/BE of Oral Drug Products
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2011-06-30
    • Data Source
      KAKENHI-PROJECT-21590051
  • [Presentation] デンドリマー型アルブチンの化学構造とSGLT1(Na+/糖共輸送体)の阻害活性との相関の検証2011

    • Author(s)
      金光俊, 佐久間信至, 寺岡裕美, 政岡祥江, 片岡誠, 山下伸二, 白坂善之, 玉井郁巳, 村岡雅弘, 中辻洋司, 木田敏之, 明石満
    • Organizer
      第27回日本DDS学会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-09
    • Data Source
      KAKENHI-PROJECT-21590051
  • [Presentation] Polyamidoamine dendrimers enhance inhibitory effect of arbutin on SGLT1-mediated glucose uptake through their conjugation2009

    • Author(s)
      Yumi Teraoka, Shinji Sakuma, Yoshie Masaoka, Makoto Kataoka, Shinji Yamashita, Yoshiyuki Shirasaka, Ikumi Tamai, Toshiyuki Kida, Mitsuru Akashi
    • Organizer
      2009 American Association of Pharmaceutical Scientists(AAPS) Annual Meeting and Exposition
    • Place of Presentation
      Los Angeles, CA
    • Year and Date
      2009-11-11
    • Data Source
      KAKENHI-PROJECT-21590051
  • [Presentation] 末端にグリコシル基を持つデンドリマーによるNa+/糖共輸送体阻害能の検証2009

    • Author(s)
      寺岡裕美, 佐久間信至, 政岡祥江, 片岡誠, 山下伸二, 白坂善之, 玉井郁巳, 木田敏之, 明石満
    • Organizer
      第25回日本DDS学会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-03
    • Data Source
      KAKENHI-PROJECT-21590051
  • [Presentation] グルコース側鎖を有する高分子複合体の経口抗糖尿病薬としての可能性評価2009

    • Author(s)
      寺岡裕美, 佐久間信至, 政岡祥江, 片岡誠, 山下伸二, 白坂善之, 玉井郁巳, 木田敏之, 明石満
    • Organizer
      第31回日本バイオマテリアル学会大会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-16
    • Data Source
      KAKENHI-PROJECT-21590051
  • 1.  KOHNO Takeyuki (50178224)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  SAKUMA Shinji (80388644)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 3.  KIDA Toshiyuki (20234297)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 4.  SEZAKI Hitoshi (50025681)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  TAKI Yoko (90258088)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  SAKANE Toshiyasu (50215638)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  AKASHI Mitsuru (20145460)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 8.  NADAI Tanekazu (80076710)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  YATA Noboru (70028835)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  玉井 郁巳 (20155237)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results

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