YAMASHITA Shinji 山下伸二

Researcher Number	00158156
Other IDs
Affiliation (Current)	2022: 摂南大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2009 – 2011: 摂南大学, 薬学部, 教授 2006 – 2007: 摂南大学, 薬学部, 教授 1994 – 1999: SETSUNAN UNIVERSITY,PHARMACY,ASSOCIATE PROFESSOR, 薬学部, 助教授 1993: 摂南大学, 薬学部, 講師
Review Section/Research Field	Principal Investigator Physical pharmacy / 応用薬理学・医療系薬学 Except Principal Investigator Physical pharmacy / Physical pharmacy / Medical pharmacy
Keywords	Principal Investigator 経口投与 / 消化管吸収 / エンケファリン / bioavailability / 代謝阻害 / 初回通過代謝 / ovalbumin / 鼻腔内投与 / リンパ移行 / liposome … More Except Principal Investigator 高分子複合体 / 配糖体 / 糖尿病 / ヘキソーストランスポーター / インクレチン / デンドリマー / SGLT1 / GLP-1 / 消化管 / 糖鎖 / 経口投与 / 薬物吸収 / 消化管灌流法 / ヒト培養細胞 / 薬動学的モデル / ペプチド性医薬品 / 吸収速度定数 / 酵素阻害剤 / 膜透過性 / Caco-2単層膜 / 薬物吸収モデル / oral administration / drug absorption / intestinal perfusion / cultured human cell line / pharmacokinetic model / peptide drug / マイクロダイアリシス / 経皮吸収 / 経皮適用製剤 / 皮膚内滞留性 / 吸収促進剤 / 皮膚内滞菌性 / microdialysis / percutaneous absorption / transdermal delivery preparations / retention in skin tissue / absorption enhancer / 大腸癌 / 内視鏡 / 造影剤 / レクチン / ナノメディシン / Colorectal cancer / Endoscopy / Imaging agent / Lectin / Nanomedicine Less

Manipulation of gastrointestinal functions by polymeric conjugates bearing glucosides, oral anti-diabetic drugs
- Principal Investigator
  
  SAKUMA Shinji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Setsunan University
Study on diagnosis and treatment of cancer in the gastrointestine using cancer-recognizable nanocarriers
- Principal Investigator
  
  SAKUMA Shinji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Setsunan University
Use of Oral Tolerance to Improve the Disposition of Protein Drugs in the BodyPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Shinji
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Setsunan University
Evaluation of bases for topical preparations by microdialysis
- Principal Investigator
  
  YATA Noboru
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Setsunan University
培養細胞を用いた薬物の消化管吸収スクリーニングシステムの開発Principal Investigator
- Principal Investigator
  
  山下伸二
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Setsunan University
エイズウイルスの性交渉感染予防を目的とした経口ワクチンの開発Principal Investigator
- Principal Investigator
  
  山下伸二
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Setsunan University
高分子薬品の生体内移行性の速度論的解析に基づく新規投与システムの開発Principal Investigator
- Principal Investigator
  
  山下伸二
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Setsunan University
ペプチド性医薬品の消化管での代謝・吸収に関する速度論的研究Principal Investigator
- Principal Investigator
  
  山下伸二
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Setsunan University
PREDICTION AND OPTIMIZATION OF DRUG ABSORPTION FROM THE GASTRO-INTESTINAL TRACT
- Principal Investigator
  
  SEZAKI Hitoshi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  SETSUNAN UNIVERSITY

All 2012 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] Carboxyl group-terminated polyamidoamine dendrimers bearing glucosides inhibit intestinal hexose transporter-mediated D-glucose uptake2010
- Author(s)
  Shinji Sakuma, Yumi Teraoka, Tomokazu Sagawa, Yoshie Masaoka, Makoto Kataoka, Shinji Yamashita, Yoshiyuki Shirasaka, Ikumi Tamai, Yusuke Ikumi, Toshiyuki Kida, Mitsuru Akashi
- Journal Title
  
  Eur. J. Pharm. Biopharm
  
  Volume: 75(3) Pages: 366-374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590051
[Journal Article] Involvement of functional groups on the surface of carboxyl group-terminated polyamidoamine dendrimers bearing arbutin in inhibition of Na+/glucose cotransporter 1(SGLT1)-mediated D-glucose uptake
- Author(s)
  Shinji Sakuma, Shun Kanamitsu, Yumi Teraoka, Yoshie Masaoka, Makoto Kataoka, Shinji Yamashita, Yoshiyuki Shirasaka, Ikumi Tamai, Masahiro Muraoka, Yohji Nakatsuji, Toshiyuki Kida, Mitsuru Akashi
- Journal Title
  
  Mol. Pharmaceutics
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590051
[Presentation] 消化管膜機能制御に基づく抗糖尿病作用を有する配糖体-高分子複合体の精密設計2012
- Author(s)
  佐久間信至, 金光俊, 寺岡裕美, 政岡祥江, 片岡誠, 山下伸二, 白坂善之, 玉井郁巳, 村岡雅弘, 中辻洋司, 木田敏之, 明石満
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21590051
[Presentation] Inhibitory effect of arbutin conjugated to polyamidoamine dendrimers on intestinal glucose transport2011
- Author(s)
  Shun Kanamitsu, Shinji Sakuma, Yumi Teraoka, Yoshie Masaoka, Makoto Kataoka, Shinji Yamashita, Yoshiyuki Shirasaka, Ikumi Tamai, Masahiro Muraoka, Yohji Nakatsuji, Toshiyuki Kida, Mitsuru Akashi
- Organizer
  International Symposium on BA/BE of Oral Drug Products
- Place of Presentation
  Kobe, Japan
- Year and Date
  2011-06-30
- Data Source
  KAKENHI-PROJECT-21590051
[Presentation] デンドリマー型アルブチンの化学構造とSGLT1(Na+/糖共輸送体)の阻害活性との相関の検証2011
- Author(s)
  金光俊, 佐久間信至, 寺岡裕美, 政岡祥江, 片岡誠, 山下伸二, 白坂善之, 玉井郁巳, 村岡雅弘, 中辻洋司, 木田敏之, 明石満
- Organizer
  第27回日本DDS学会
- Place of Presentation
  東京
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-21590051
[Presentation] Polyamidoamine dendrimers enhance inhibitory effect of arbutin on SGLT1-mediated glucose uptake through their conjugation2009
- Author(s)
  Yumi Teraoka, Shinji Sakuma, Yoshie Masaoka, Makoto Kataoka, Shinji Yamashita, Yoshiyuki Shirasaka, Ikumi Tamai, Toshiyuki Kida, Mitsuru Akashi
- Organizer
  2009 American Association of Pharmaceutical Scientists(AAPS) Annual Meeting and Exposition
- Place of Presentation
  Los Angeles, CA
- Year and Date
  2009-11-11
- Data Source
  KAKENHI-PROJECT-21590051
[Presentation] 末端にグリコシル基を持つデンドリマーによるNa+/糖共輸送体阻害能の検証2009
- Author(s)
  寺岡裕美, 佐久間信至, 政岡祥江, 片岡誠, 山下伸二, 白坂善之, 玉井郁巳, 木田敏之, 明石満
- Organizer
  第25回日本DDS学会
- Place of Presentation
  東京
- Year and Date
  2009-07-03
- Data Source
  KAKENHI-PROJECT-21590051
[Presentation] グルコース側鎖を有する高分子複合体の経口抗糖尿病薬としての可能性評価2009
- Author(s)
  寺岡裕美, 佐久間信至, 政岡祥江, 片岡誠, 山下伸二, 白坂善之, 玉井郁巳, 木田敏之, 明石満
- Organizer
  第31回日本バイオマテリアル学会大会
- Place of Presentation
  京都
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-21590051

1. KOHNO Takeyuki (50178224)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. SAKUMA Shinji (80388644)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
3. KIDA Toshiyuki (20234297)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. SEZAKI Hitoshi (50025681)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TAKI Yoko (90258088)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. SAKANE Toshiyasu (50215638)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. AKASHI Mitsuru (20145460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
8. NADAI Tanekazu (80076710)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. YATA Noboru (70028835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 玉井郁巳 (20155237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results

YAMASHITA Shinji 山下 伸二

Research Projects

Research Products

Co-Researchers

Manipulation of gastrointestinal functions by polymeric conjugates bearing glucosides, oral anti-diabetic drugs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on diagnosis and treatment of cancer in the gastrointestine using cancer-recognizable nanocarriers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Use of Oral Tolerance to Improve the Disposition of Protein Drugs in the BodyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of bases for topical preparations by microdialysis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

培養細胞を用いた薬物の消化管吸収スクリーニングシステムの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

エイズウイルスの性交渉感染予防を目的とした経口ワクチンの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

高分子薬品の生体内移行性の速度論的解析に基づく新規投与システムの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ペプチド性医薬品の消化管での代謝・吸収に関する速度論的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

PREDICTION AND OPTIMIZATION OF DRUG ABSORPTION FROM THE GASTRO-INTESTINAL TRACT

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Carboxyl group-terminated polyamidoamine dendrimers bearing glucosides inhibit intestinal hexose transporter-mediated D-glucose uptake2010

Author(s)

Journal Title

Data Source

[Journal Article] Involvement of functional groups on the surface of carboxyl group-terminated polyamidoamine dendrimers bearing arbutin in inhibition of Na+/glucose cotransporter 1(SGLT1)-mediated D-glucose uptake

Author(s)

Journal Title

Data Source

[Presentation] 消化管膜機能制御に基づく抗糖尿病作用を有する配糖体-高分子複合体の精密設計2012

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Inhibitory effect of arbutin conjugated to polyamidoamine dendrimers on intestinal glucose transport2011

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] デンドリマー型アルブチンの化学構造とSGLT1(Na+/糖共輸送体)の阻害活性との相関の検証2011

Author(s)

YAMASHITA Shinji 山下伸二