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AZUMA Hiroshi  東 寛

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… Alternative Names

東 寛  アズマ ヒロシ

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Researcher Number 00167909
Other IDs
Affiliation (Current) 2025: 旭川医科大学, 医学部, 名誉教授
Affiliation (based on the past Project Information) *help 2023: 旭川医科大学, 医学部, 名誉教授
2021: 旭川医科大学, 医学部, 名誉教授
2019 – 2020: 旭川医科大学, 医学部, 特命教授
2013 – 2019: 旭川医科大学, 医学部, 教授
1995: Asahikawa Medical College, Department of Pediatrics, Associate, 医学部, 講師
1993: ASAHIKAWA MEDICAL COLLEGE DEPT PED, INSTRUCTOR, 医学部, 助手
1989 – 1991: 旭川医科大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Pediatrics / Basic Section 54010:Hematology and medical oncology-related / Pediatrics
Except Principal Investigator
Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords
Principal Investigator
B7-H3 / MDSC / リポソーム / NFkB / macrophage / iNOS / マクロファージ / liposome / MDSD / ER stress … More / micro vesicle / MAP kinase / fatty acid / 刺激伝達系 / B7H3 / exosome / extosome / microvesicle / 抑制性マクロファージ / central nervous system infection / liopolysaccharide / herpes simplex infection / astorcytoma / glioblastoma / cerebro spinal fluid / soluble interleukin 6 receptor / interleukin 6 / チリオブラストーマ / 中枢神経感染症 / リポポリサッカライド / 単純ヘルペス感染症 / アストロサイトーマ / グリオブラストーマ / 脳脊髄液 / 可溶性IL6レセプター / IL6 / CD276 / B7 family / regulatory macrophage / ectosome / ナノ粒子 / immunosuppression … More
Except Principal Investigator
テストステロン / 成長速度 / ゴナドトロピン / 長日リズム / 縮日リズム / 概日リズム / 小胞体ストレス / MDSC / 免疫チェックポイント分子 / iNOS / NF-kB / マクロファージ / リポソーム / PUBERTY / TESTOSTERONE / FOLLICLE STIMULATING HORMONE / LETEINIZING HORMONE / INFRADIAN RHYTHM / ULTRADIAN RHYTHM / CIRCADIAN RHYTHM / インターロイキン / 性成熟 / 二次性徴 / 思春期 / 卵胞刺激ホルモン / 黄体化ホルモン / Growth Velocity / 17-Hydroxyprogesterone / Gonadotropin / Growth hormone / Infradian Rhythm / Ultradian Rhythm / Circadian Rhythm / 170Hプロケステロン / 先天性副腎過形成 / タ-ナ-症候群 / 成長ホルモン欠損症 / 概日性リズム / 性腺刺激ホルモン / 170Hプロゲステロン / 成長ホルモン Less
  • Research Projects

    (7 results)
  • Research Products

    (19 results)
  • Co-Researchers

    (21 People)
  •  リポソームを捕捉したマクロファージのMDSC様細胞への変容に関わる分子基盤の解明

    • Principal Investigator
      吉田 陽一郎
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Asahikawa Medical College
  •  Search into the mechanism of B7-H3 expressing MDSC generation by liposome and its T cell suppressionPrincipal Investigator

    • Principal Investigator
      Azuma Hiroshi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Asahikawa Medical College
  •  Mechanism of B7-H3 expression on liposome induced MDSC-like cell and its influence on immunosuppressionPrincipal Investigator

    • Principal Investigator
      Hiroshi Azuma
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Asahikawa Medical College
  •  Detection of molecules involved in the induction of immunosuppressive function of MDSC-like cells induced by liposomePrincipal Investigator

    • Principal Investigator
      AZUMA Hiroshi
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Asahikawa Medical College
  •  Analysis of interleukin 6 and its soluble receptor in cerebrospinal fluidPrincipal Investigator

    • Principal Investigator
      AZUMA Hiroshi
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Asahikawa Medical College
  •  STUDIES ON THE DEVELOPMENT OF CIRCADIAN, ULTARADINAN AND INFRADIAN RHYTHMS IN BIOLOGICAL ACTIVITY.

    • Principal Investigator
      OKUNO Akimasa
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      ASAHIKAWA MEDICAL COLLEGE
  •  Studies on the Development of Circadian and Ultradian Rhythms in the Hypothalamo-Pituitary System in Children and Adolescents

    • Principal Investigator
      OKUNO Akimasa
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Asahikwa Medical College

All 2020 2019 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book Patent

  • [Book] Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics2014

    • Author(s)
      Hiroshi Azuma, Mitsuhiro Fujihara, Hiromi Sakai
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-25461578
  • [Journal Article] Contribution of long-chain fatty acid to induction of myeloid-derived suppressor cell (MDSC)-like cells- Induction of MDSC by lipid vesicles (liposome)2020

    • Author(s)
      Yoshida Y, Nagamori T, Ishibazaawa E, Kobayashi H, Kure T, Sakai H, Takahashi D, Fujihira F, Azuma h
    • Journal Title

      IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

      Volume: 42 Issue: 6 Pages: 614-624

    • DOI

      10.1080/08923973.2020.1837866

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08854
  • [Journal Article] Liposomal microparticle injection can induce myeloid-derived suppressor cells(MDSC)-like cells in vivo2017

    • Author(s)
      Azuma h, Yoshida Y, Takahashi H, Ishibazawa E, Kobayashi H, Sakai H, Takahashi D, Fujihara M
    • Journal Title

      Immunopharmacol Immunotoxicol

      Volume: 39 Issue: 3 Pages: 140-147

    • DOI

      10.1080/08923973.2017.1306867

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25461578, KAKENHI-PROJECT-16K10010
  • [Journal Article] Biocompatibility of HbV: Liposome-Encapsulated Hemoglobin Molecules-Liposome Effects on Immune Function2017

    • Author(s)
      Azuma H, Fujihara M, Sakai H
    • Journal Title

      J Funct Biomate

      Volume: 8 Issue: 3 Pages: 24-24

    • DOI

      10.3390/jfb8030024

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K10010
  • [Journal Article] Primary and secondary immune response to keyhole limpet hemocyanin in rats after infusion of hemoglobin vesicles, an artificial oxygen carrier2013

    • Author(s)
      Fujihara M, Takahashi D, Abe, H, Sakai H, Horinouchi H, KObayashi K, Ikeda H, Azuma H
    • Journal Title

      Artif Organs

      Volume: 38 Issue: 3 Pages: 234-238

    • DOI

      10.1111/aor.12148

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461578
  • [Patent] リポソームを含有する免疫抑制剤及びこれを用いた抑制性マクロフ ァージの誘導方法2015

    • Inventor(s)
      東  寛、酒井宏水
    • Industrial Property Rights Holder
      旭川医科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-04-01
    • Data Source
      KAKENHI-PROJECT-25461578
  • [Patent] リポソームを含有する免疫抑制剤及びこれを用いた抑制性マクロファージ の誘導方法2015

    • Inventor(s)
      東 寛、酒井宏水
    • Industrial Property Rights Holder
      国立大学法人旭川医科大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-068296
    • Filing Date
      2015-03-30
    • Data Source
      KAKENHI-PROJECT-25461578
  • [Presentation] HbVを構成しているリポソームの細網内皮系細胞への取り込み機序の検討2020

    • Author(s)
      東  寛、酒井 宏水
    • Organizer
      第27回日本血液代替物学会年次大会
    • Data Source
      KAKENHI-PROJECT-19K08854
  • [Presentation] Induction of B7-H3 positive myeloid-derived suppressor cells(MDSC) by liposomal nanoparticles2019

    • Author(s)
      Azuma H, Yoshida Y, Nagamori T, Ishibazawa E, Kobayashi H, Skai H, Takahashi D, Fujihara M
    • Organizer
      The 17th international Symposium on Blood Substitute and Oxygen Therapeutics
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K08854
  • [Presentation] HbVに使用されているリポソーム粒子のマクロファージへの影響について2017

    • Author(s)
      東  寛
    • Organizer
      第24回日本血液代替物学会年次大会
    • Data Source
      KAKENHI-PROJECT-16K10010
  • [Presentation] リポソームにより誘導される抑制性マクロファージの機能解析2016

    • Author(s)
      東 寛
    • Organizer
      第23回日本血液代替物学会
    • Place of Presentation
      東京
    • Year and Date
      2016-11-24
    • Data Source
      KAKENHI-PROJECT-16K10010
  • [Presentation] Membrane-derived microvesicleによる免疫抑制細胞(MSC)の誘導について2016

    • Author(s)
      東 寛
    • Organizer
      北日本小児科学会
    • Place of Presentation
      弘前
    • Data Source
      KAKENHI-PROJECT-25461578
  • [Presentation] Menbrane-derived microvesicleによる免疫抑制細胞(MDSC)の誘導について2016

    • Author(s)
      東 寛
    • Organizer
      北日本小児科学会
    • Place of Presentation
      弘前
    • Data Source
      KAKENHI-PROJECT-16K10010
  • [Presentation] リポソームにより誘導される抑制性マクロファージの機能解析2016

    • Author(s)
      東 寛
    • Organizer
      第23回日本血液代替物学会
    • Place of Presentation
      東京
    • Year and Date
      2016-11-24
    • Data Source
      KAKENHI-PROJECT-25461578
  • [Presentation] 人工赤血球(ヘモグロビン小胞体)を構成する脂質2重膜の薬理作用について2015

    • Author(s)
      東  寛、吉田陽一郎、高橋弘典、高橋大輔、藤原満博、酒井宏水
    • Organizer
      日本血液代替物学会
    • Place of Presentation
      熊本
    • Year and Date
      2015-10-22
    • Data Source
      KAKENHI-PROJECT-25461578
  • [Presentation] リポソームの投与後の脾細胞からCon A刺激により産生されるサイトカイン・ケモカイン動態の網羅的解析2013

    • Author(s)
      東  寛, 高橋弘典, 永井一樹, 長森恒久, 高橋大輔, 藤原満博, 酒井宏水
    • Organizer
      第20回日本血液代替物学会年次大会
    • Place of Presentation
      奈良県新公会堂
    • Data Source
      KAKENHI-PROJECT-25461578
  • [Presentation] 人工赤血球(ヘモグロビン小胞体)を構成する脂質2重膜のもつ免疫調節効果について2013

    • Author(s)
      東  寛,  酒井宏水
    • Organizer
      第20回日本血液代替物学会年次大会
    • Place of Presentation
      奈良県新公会堂
    • Data Source
      KAKENHI-PROJECT-25461578
  • [Presentation] 輸血治療を補完する人工赤血球の効力と安全性

    • Author(s)
      東 寛、藤原満博、酒井宏水
    • Organizer
      第62回日本輸血細胞治療学会
    • Place of Presentation
      奈良
    • Year and Date
      2014-05-15 – 2014-05-17
    • Data Source
      KAKENHI-PROJECT-25461578
  • [Presentation] 人工赤血球製剤(ヘモグロビン小胞体)の効能を安全性

    • Author(s)
      東 寛
    • Organizer
      第21回日本血液代替物学会
    • Place of Presentation
      東京
    • Year and Date
      2014-12-08 – 2014-12-09
    • Data Source
      KAKENHI-PROJECT-25461578
  • 1.  酒井 宏水 (70318830)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 10 results
  • 2.  長森 恒久 (40400098)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 3.  吉田 陽一郎 (80750306)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  OKUNO Akimasa (10000960)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  OKI Junichi (60152401)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  YANO Koichi (60182383)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  OKA Toshiaki (30111206)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  高橋 弘典 (50431408)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 9.  岡嶋 一樹 (70213931)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  更科 岳大 (40431407)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  OKA Ryuji (40113724)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  KAKUYA Fujio (70240645)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  ITO Yoshiya (70241437)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  古谷野 伸 (30312458)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  鳥海 尚久 (30516399)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  佐藤 雅之 (00624181)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  甲賀 大輔 (30467071)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  青山 藍子 (60596295)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  石羽澤 映美 (90516402)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  佐々木 一弘
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  鈴木 直己
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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