Sakai Hiromi 酒井宏水

… Alternative Names

Researcher Number	70318830
Other IDs
External Links
Affiliation (Current)	2020: 奈良県立医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2013 – 2019: 奈良県立医科大学, 医学部, 教授 2014: 奈良県立医科大学, 医学部・化学教室, 教授 2012: 早稲田大学, 重点領域研究機構, 教授 2012: 早稲田大学, 附属研究所, 教授 2011: 早稲田大学, 重点領域研究機構, 准教授 … More
Review Section/Research Field	Principal Investigator Biomedical engineering/Biological material science / Biomedical engineering/Biomaterial science and engineering / Medical systems / Biomedical engineering/Biological material science Except Principal Investigator Pediatrics / Respiratory surgery / Thoracic surgery / Biomedical engineering/Biological material science / Parasitology (including Sanitary zoology) / Biomedical engineering/Biological material science … More
Keywords	Principal Investigator 人工赤血球 / 人工血液 / リポソーム / 輸血代替 / ヘモレオロジー / ヘモグロビン / 人工臓器工学 / 生体材料 / ナノバイオ / 生体機能利用 … More Except Principal Investigator 人工赤血球 / ヘモグロビン小胞体 / リポソーム / B7-H3 / 移植・再生医療 / MDSC / マクロファージ / iNOS / ヘモグロビン / 出血性ショック / 血液代替物 / 呼吸器外科 / 胎児脳 / 胎児低酸素血症 / 胎児低酸素症 / 原虫 / マラリア / 補助療法 / 感染症 / 微生物 / 輸血 / immunosuppression / liposome / ナノ粒子 / ectosome / regulatory macrophage / B7 family / CD276 / 製造工程 / 人工肺 / 凍結融解・凍結乾燥 / 多段・連結式高圧押出装置 / ポリオキシエチレン脂質 / アミノ酸型脂質 / 電気化学的脱酸素化 / 一酸化炭素化ヘモグロビン / 多段・凍結式高圧押出装置 / 細胞型酸素輸液 / 多段式高圧押出機 / hemoglobin / hemoglobin vesicles / production procass / artificial lung / freeze-thawing / freeze-drying / multistage-combined type extruder / polyoxyethylene-conjugated lipids / aminolipid / 換気不全 / 無呼吸 / 循環虚脱 / 酸素輸液 / 呼吸停止 / 蘇生 / 人工血液 / ラット / 外科手術 / 肺切除 / 呼吸不全 / 人工酸素運搬体 / 肺損傷 / 抑制性マクロファージ / NFkB / microvesicle / extosome / exosome / B7H3 / 刺激伝達系 / 臓器保存 / 肺移植 / 呼吸器外科学 / 虚血再還流 / 臓器保護 / 外科 / 虚血再灌流生涯 / 救急医療 / 凝固障害 / 病院前治療 / 蘇生輸血 / 次世代保育器 / 人工血液カクテル / 血液呼吸 / 早産児 / 血液換気ユニット / 高分子 / 高分子合成 / 生体材料 / 医療・福祉 / 臓器灌流保存 / 心肺停止ドナー / 虚血再灌流障害 / １肝臓灌流保存 / ２心停止ドナー / ３人工赤血球含有灌流液 / ４虚血再灌流障害 / MDSD Less

Search into the mechanism of B7-H3 expressing MDSC generation by liposome and its T cell suppressionOngoing
- Principal Investigator
  
  東寛
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Asahikawa Medical College
人工血液カクテルによる次世代保育器の開発Ongoing
- Principal Investigator
  
  太田英伸
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  National Center of Neurology and Psychiatry
Synthesis and in vivo characterization of polymer-multilinked hemoglobin assembly as artificial oxygen carrierOngoing
- Principal Investigator
  
  松平崇
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Nara Medical University
Application of artificial oxygen-carrying hemoglobin vesicles for marginal liver grafts in machine perfusion preservationOngoing
- Principal Investigator
  
  松野直徒
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Asahikawa Medical College
Artificial red cells with a defense function to oxidative stressPrincipal InvestigatorOngoing
- Principal Investigator
  
  酒井宏水
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Nara Medical University
リポソーム誘導MDSCに発現するB7-H3分子誘導機序とその免疫抑制効果への関与Ongoing
- Principal Investigator
  
  東寛
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Asahikawa Medical College
Reducing ischemic lung perfusion injury by artificial hemoglobin
- Principal Investigator
  
  MIYAZAKI Takuro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Nagasaki University
Combination therapy using fibrinogen gamma-chain peptide-coated, ADP-encapsulated liposomes and hemoglobin vesicles for trauma-induced massive hemorrhage
- Principal Investigator
  
  Hagisawa Kohsuke
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  National Defense Medical College
呼吸停止時の人工赤血球の有用性の検討Ongoing
- Principal Investigator
  
  内藤祐介
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Nara Medical University
  Osama Woman's and Children's Hospital
Prolonged functional lifespan of artificial red cells by using the electron energies produced by erythrocyte glycolysisPrincipal Investigator
- Principal Investigator
  
  SAKAI HIROMI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Nara Medical University
Detection of molecules involved in the induction of immunosuppressive function of MDSC-like cells induced by liposome
- Principal Investigator
  
  AZUMA Hiroshi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Asahikawa Medical College
Effect of oxygen infusion with hemoglobin vesicles on respiratory insufficiency
- Principal Investigator
  
  KOHNO Mitsutomo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Tokai University
  Keio University
Development of a novel therapy for fetal hypoxia used by artificial oxygen carriers (hemoglobin vesicles)
- Principal Investigator
  
  LI Heng
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  National Center of Neurology and Psychiatry
Microhemodynamic properties and gas reactions of abnormal RBCs in narrow tubesPrincipal Investigator
- Principal Investigator
  
  SAKAI Hiromi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical systems
- Research Institution
  Nara Medical University
  Waseda University
Development of an adjuvant therapy for severe malaria with the hemoglobin vesicle, an artificial oxygen carrier.
- Principal Investigator
  
  KANO Shigeyuki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Parasitology (including Sanitary zoology)
- Research Institution
  独立行政法人国立国際医療研究センター
Bioengineering of artificial red cells for clinical applicationPrincipal Investigator
- Principal Investigator
  
  SAKAI Hiromi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Waseda University
Application of hemoglobin vesicles for lung transplantation
- Principal Investigator
  
  KOHNO Mitsutomo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Keio University
Artificial Red Cells : Physiological Importance of the Ligand Reaction Dynamism and the New Application for Ligand TherapyPrincipal Investigator
- Principal Investigator
  
  SAKAI Hiromi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Waseda University
"Analysis of oxygen releasing behavior of hemoglobin-vesicles (nano-particles) and the mechanism of oxygenation of ischemic tissue."Principal Investigator
- Principal Investigator
  
  SAKAI Hiromi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Waseda University
Microhemodynamics after Infusion of an Artificial O_2 Carriers Using Laser Flash Irradiation.Principal Investigator
- Principal Investigator
  
  SAKAI Hiromi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Waseda University
Establishment of production process of cellular- type oxygen carriers
- Principal Investigator
  
  TAKEOKA Shinji
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Waseda University

[Book] Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics2014
- Author(s)
  Hiroshi Azuma, Mitsuhiro Fujihara, Hiromi Sakai
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25461578
[Book] Hemoglobin-based oxygen carriers; principles, approaches and current status (H.W. Kim & A.G. Greenburg eds.)2013
- Author(s)
  Hiromi Sakai
- Publisher
  Springer-Verlag
- Data Source
  KAKENHI-PROJECT-22300161
[Book] Biocompatibility of a highly concentrated fluid of Hemoglobin-vesicles as a transfusion alternative. In : Selective Topics in Nanomedicine (T.M.S. Chang ed.)2013
- Author(s)
  H. Sakai
- Publisher
  World Scientific, Singapore
- Data Source
  KAKENHI-PROJECT-24650301
[Book] Hemoglobin-vesicles as a cellular type hemoglobin-based oxygen carrier. In : Chemistry and Biochemistry of Oxygen Therapeutics : from Transfusion to Artificial Blood. (Ed. by S. Bettati and A. Mozzarelli), Chapter 272011
- Author(s)
  H. Sakai, H. Horinouchi, E. Tsuchida, K. Kobayashi
- Publisher
  John Wiley & Sons
- Data Source
  KAKENHI-PROJECT-22300161
[Book] Hb-vesicles as a cellular type Hb-based O2 carrier. In : Chemistry and Biochemistry of Oxygen The rapeutics(Bettati & Mozzarelli, Ed.)2011
- Author(s)
  H.Sakai, H.Horinouchi, E.Tsuchida, K.Kobayashi
- Total Pages
  442
- Publisher
  John Wiley & Sons
- Data Source
  KAKENHI-PROJECT-22300161
[Book] Academia-industry collaboration in blood substitute development. - issues, case histories and a proposal. In : Chemistry and Biochemistry of Oxygen Therapeutics : from Transfusion to Artificial Blood. (Ed. by S. Bettati and A. Mozzarelli), Chapter 292011
- Author(s)
  H.W. Kim, A. Mozzarelli, H. Sakai, J. Jahr
- Publisher
  John Wiley & Sons
- Data Source
  KAKENHI-PROJECT-22300161
[Book] Artificial oxygen carriers (hemoglobin-vesicles) as a transfusion alternative and for oxygen therapeutics2011
- Author(s)
  H. Sakai
- Publisher
  IFMBE Proceedings 35 (5th Kuala Lumpur International Conference on Biomedical Engineering 2011 (BIOMED 2011)
- Data Source
  KAKENHI-PROJECT-22300161
[Book] Academia-industry collaboration in blood substitute development. In : Chemistry and Biochemistry of Oxygen Therapeutics(Bettati & Mozzarolli, Ed.)2011
- Author(s)
  H.W.Kim, A.Mozzarelli, H.Sakai, J.Jahr
- Total Pages
  442
- Publisher
  John Wiley & Sons
- Data Source
  KAKENHI-PROJECT-22300161
[Book] Oxygen Transport to Tissue XXXI(Hemoglobin-vesicle, a cellular artificial oxygen carrier, that fulfils the physiological roles of the red blood cells structure).2010
- Author(s)
  H. Sakai, K. Sou, H. Horinouchi, K. Kobayashi, E. Tsuchida
- Publisher
  Adv. Exp. Med. Biol.
- Data Source
  KAKENHI-PROJECT-19300164
[Book] 人工酸素運搬体.「からだと酸素の事典」酸素ダイナミクス研究会編.第5章:酸素の利用.pp.478-4842009
- Author(s)
  堀之内宏久, 小林紘一, 酒井宏水, 土田英俊
- Total Pages
  583
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-19300164
[Book] Hemoglobin vesicles as a transfusion alternative2009
- Author(s)
  H. Sakai, K. Sou, E. Tsuchida
- Publisher
  Methods Enzymol
- Data Source
  KAKENHI-PROJECT-19300164
[Book] Blood Substitutes (Ed.By Robert M.Winslow), Chapt.44, pp.514-5222006
- Author(s)
  Sakai H, Sou K, Takeoka S, Kobayashi K, Tsuchida E
- Total Pages
  9
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-16300162
[Book] "Blood Substitutes",In : Wiley Encyclopedia of Biomedical Engineering.M.Akay (Ed.),2006
- Author(s)
  H.Sakai, E.Tsuchida
- Publisher
  John Wiley＆Sons,Inc.,Hoboken,NJ.
- Data Source
  KAKENHI-PROJECT-16300162
[Book] Microvascular Research : Biology and Pathology, Vol. 2. "Blood Substitutes' Efficacy : Microvascular and Theological Determinants."(Ed : David Shepro)2006
- Author(s)
  A.G.Tsai, P.Cabrales, H.Sakai, M.Intaglietta
- Publisher
  Elsevier
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Book] Blood Substitutes (Wiley Encyclopedia of Biomedical Engineering.) (M. Akay (Ed.))2006
- Author(s)
  H.Sakai, E.Tsuchida
- Publisher
  John Wiley ＆ Sons, Inc., Hoboken, NJ.
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Book] Microvascular Research : Biology and Pathology, Vol.2(Ed.by David Shepro), pp.1095-11032006
- Author(s)
  Tsai AG, Cabrales P, Sakai H, Intaglietta M.
- Total Pages
  9
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-16300162
[Book] "Blood Substitutes" Chapt. 44 "Hemoglobin-Vesicles as a Molecular Assembly : Characteristics of Preparation Process and Performances as Artificial Oxygen Carriers." (Ed. By Robert M. Winslow)2006
- Author(s)
  H.Sakai, K.Sou, S.Takeoka, K.Kobayashi, E.Tsuchida
- Publisher
  Elsevier
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Book] Artificial Oxygen Carrier : Its Front Line, Keio University International Symposia for Life Sciences and Medicine Vol.12 (Eds. by K. Kobayashi, E. Tsuchida, and H. Horinouchi) ("Hemoglobin-vesicles (HbV) as Artificial Oxygen Carriers")2005
- Author(s)
  H.Sakai, K.Sou, S.Takeoka, K.Kobayashi, E.Tsuchida
- Publisher
  Springer-Verlag (2005).
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Book] 先端医療シリーズ37「人工臓器・再生医療の最先端」第16章-4.pp.279-2862005
- Author(s)
  土田英俊, 酒井宏水, 小松晃之, 小林紘一
- Total Pages
  8
- Publisher
  寺田国際事務所/先端医療技術研究所
- Data Source
  KAKENHI-PROJECT-16300162
[Book] "Hb-vesicles as Artificial O2 Carriers". In : Artificial O2 Carrier : Its Front Line, Keio Univ.Intern.Symp.for Life Sci.& Med.Vol.12(Eds.by K.Kobayashi, E.Tsuchida, and H.Horinouchi.)2005
- Author(s)
  Sakai H, Sou K, Takeoka S, Kobayashi K, Tsuchida E.
- Publisher
  Springer-Verlag
- Data Source
  KAKENHI-PROJECT-16300162
[Book] "Safety and Efficacy of Hb-Vesicles and Albumin-Hemes". In : Artificial O2 Carrier : Its Front Line, Keio Univ.Intern.Symp.for Life Sci.& Med.Vol.12(Eds.by K.Kobayashi, E.Tsuchida, and H.Horinouchi.)2005
- Author(s)
  Kobayashi, Horinouchi, Sakai, komatsu, Takeoka, Tsuchida, et al.
- Publisher
  Springer-Verlag
- Data Source
  KAKENHI-PROJECT-16300162
[Book] 先端医療シリーズ37「人工臓器・再生医療の最先端」第16章-4.酸素輸液(人工赤血球)の臨床応用2005
- Author(s)
  土田英俊, 酒井宏水, 小松晃之, 小林紘一
- Publisher
  寺田国際事務所/先端医療技術研究所
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Book] 「医療用マテリアルと機能膜」第5章、人工赤血球2005
- Author(s)
  酒井宏水, 宗慶太郎, 武岡真司, 小林紘一, 土田英俊
- Publisher
  (株)シーエムシー出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Book] 「新訂版・表面科学の基礎と応用」編者 : 日本表面科学会第5章第12節"人工赤血球"2004
- Author(s)
  土田英俊, 武岡真司, 小松晃之, 酒井宏水
- Publisher
  エヌ・ティー・エス社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Book] "人工赤血球"「新訂版・表面科学の基礎と応用」第5章第12節2004
- Author(s)
  土田英俊, 武岡真司, 小松晃之, 酒井宏水
- Publisher
  編者:日本表面科学会、エヌ・ティー・エス社
- Data Source
  KAKENHI-PROJECT-16300162
[Book] Biocompatibility of a highly concentrated fluid of Hemoglobin-vesicles as a transfusion alternative. In : Selective Topics in Nanomedicine (T.M.S. Chang ed.)
- Author(s)
  H. Sakai
- Publisher
  World Scientific, Singapore (in press)
- Data Source
  KAKENHI-PROJECT-22300161
[Book] Cellular-type hemoglobin-based oxygen carriers to mimic the red blood cells structure. In : Hemoglobin-based oxygen carriers .principles, approaches and current status (H.W. Kim & A.G. Greenburg eds.)
- Author(s)
  H. Sakai
- Publisher
  Springer-Verlag (Berlin/Heidelberg, Germany) (in press)
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Ring-Opening Polymerization of Hemoglobin2019
- Author(s)
  T. Matsuhira, K. Yamamoto, H. Sakai
- Journal Title
  
  Biomacromolecules
  
  Volume: 20(4) Pages: 1592-1602
- DOI
  10.1021/acs.biomac.8b01789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01367, KAKENHI-PROJECT-17K09018
[Journal Article] Combination therapy using fibrinogen gamma-chain peptide-coated, ADP-encapsulated liposomes and hemoglobin vesicles for trauma-induced massive hemorrhage in thrombocytopenic rabbits2019
- Author(s)
  Hagisawa K, Kinoshita M, Takikawa M, Takeoka S, Saitoh D, Seki S, Sakai H
- Journal Title
  
  Transfusion
  
  Volume: 59
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11435
[Journal Article] Antioxidative Pseudoenzymatic Mechanism of NAD(P)H Coexisting with Oxyhemoglobin for Suppressed Methemoglobin Formation.2019
- Author(s)
  Magohei Yamada, Takashi Matsuhira, Keizo Yamamoto, Hiromi Sakai
- Journal Title
  
  Boichemistry
  
  Volume: 58 Pages: 1400-1410
- DOI
  10.1021/acs.biochem.8b01314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09018, KAKENHI-PROJECT-17H02087
[Journal Article] 心停止ドナーへの肝移植に対する人工赤血球（Hemoglobin vesicles, HbV）を用いた灌流保存方法の有効性2018
- Author(s)
  庄中　達也、松野　直徒、小原　弘道、吉川　遼、西川　祐司、合地　美香子、大谷　将秀、高橋　裕之、東　寛、酒井　宏水、古川　博之
- Journal Title
  
  北海道外科雑誌
  
  Volume: 63 Pages: 46-48
- NAID
  40021786031
- Data Source
  KAKENHI-PROJECT-17K10503
[Journal Article] 蛍光偏光解消法による高濃度蛋白質溶液を内包したリポソーム脂質膜の流動性評価.2018
- Author(s)
  久禮智子、酒井宏水
- Journal Title
  
  Jasco Report
  
  Volume: 60 Pages: 34-41
- NAID
  40021654250
- Data Source
  KAKENHI-PROJECT-17H02087
[Journal Article] 輸血代替の他にもさまざまな利用が期待される「人工赤血球」とは2018
- Author(s)
  酒井宏水
- Journal Title
  
  Medical Technology
  
  Volume: 46 Pages: 832-834
- Data Source
  KAKENHI-PROJECT-17H02087
[Journal Article] Analysis of Dimeric ab Subunit Exchange between PEGylated and Narive Hemoglobins (α2β2 Tetramer) in Equilibrated State by Intramolecular bb-Cross-Linking2018
- Author(s)
  T. Matsuhira, T. Kure, K. Yamamoto, H. Sakai
- Journal Title
  
  Biomacromolecules
  
  Volume: 19(8) Pages: 3412-3420
- DOI
  10.1021/acs.biomac.8b00728
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01367, KAKENHI-PROJECT-17K09018
[Journal Article] In vivo evaluation of electron mediators for the reduction of methemoglobin encapsulated in liposomes using electron energies produced by red blood cell glycolysis.2018
- Author(s)
  Ghirmai S, Bulow L, Sakai H
- Journal Title
  
  Artif Cells Nanomed Biotechnol.
  
  Volume: 46 Pages: 1364-1372
- DOI
  10.1080/21691401.2017.1397003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02087
[Journal Article] Efficacy of Resuscitative Transfusion With Hemoglobin Vesicles in the Treatment of Massive Hemorrhage in Rabbits With Thrombocytopenic Coagulopathy and Its Effect on Hemostasis by Platelet Transfusion2018
- Author(s)
  Hagisawa, Kohsuke; Kinoshita, Manabu; Takase, Bonpei; Hashimoto, Kenichi; Saitoh, Daizoh; Seki, Shuhji; Nishida, Yasuhiro; Sakai, Hiromi
- Journal Title
  
  SHOCK
  
  Volume: in press Pages: 324-330
- DOI
  10.1097/shk.0000000000001042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11435, KAKENHI-PROJECT-18H02907
[Journal Article] Sodium hydroxide based non-detergent decellularizing solution for rat lung2018
- Author(s)
  Sengyoku H, Tsuchiya T, Obata T, Doi R, Hashimoto Y, Ishii M, Sakai H, Matsuo N, Taniguchi D,　Suematsu T, Lawn M, Matsumoto K, Miyazaki T, Nagayasu T
- Journal Title
  
  Organogenesis
  
  Volume: 14 Pages: 94-106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10686
[Journal Article] ARTIFICIAL RED CELLS (HEMOGLOBIN VESICLES) AS A TRANSFUSION ALTERNATIVE AND THEIR NEW CLINICAL APPLICATIONS2018
- Author(s)
  酒井宏水
- Journal Title
  
  JJTC
  
  Volume: 64 Issue: 4 Pages: 589-596
- DOI
  10.3925/jjtc.64.589
- NAID
  130007484096
- ISSN
  1881-3011, 1883-0625
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02087
[Journal Article] Application of Perfusate With Human-Derived Oxygen Carrier Solution Under Subnormothermic Machine Perfusion for Donation After Cardiac Death Liver Grafts in Pigs2018
- Author(s)
  Tatsuya Shonaka, Naoto Matsuno, Hiromichi Obara, Ryo Yoshikawa, Yuji Nishikawa,Mikako Goucha, Masahide Otana, Hiroyuki Takahashi, Hiroshi Azuma, Hiromi Sakai, Hiroyuki Furukawa
- Journal Title
  
  Transplantation Proceedings
  
  Volume: Transpl Proc Pages: 2821-2825
- DOI
  10.1016/j.transproceed.2018.02.184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10503, KAKENHI-PROJECT-15H03922
[Journal Article] 人工赤血球の開発と臨床応用2018
- Author(s)
  酒井宏水, 奥田千愛, 久禮智子
- Journal Title
  
  LiSA (Life Support and Anesthesia)
  
  Volume: 25 Pages: 1139-1146
- Data Source
  KAKENHI-PROJECT-17H02087
[Journal Article] Biocompatibility of HbV: Liposome-Encapsulated Hemoglobin Molecules-Liposome Effects on Immune Function2017
- Author(s)
  Azuma H, Fujihara M, Sakai H
- Journal Title
  
  J Funct Biomate
  
  Volume: 8 Pages: 24-24
- DOI
  10.3390/jfb8030024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10010
[Journal Article] Liposomal micro particle injection can induce myeloid-derived suppressor cells(MDSC)-like cells in vivo2017
- Author(s)
  Azuma h, Yoshida Y, Takahashi H, Ishibazawa E, Kobayashi H, Sakai H, Takahashi D, Fujihara M
- Journal Title
  
  Immunopharm Immunot
  
  Volume: 39 Pages: 140-147
- DOI
  10.1080/08923973.2017.1306867
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461578, KAKENHI-PROJECT-16K10010
[Journal Article] The Use of Hemoglobin Vesicles for Delivering Medicinal Gas for the Treatment of Intractable Disorders2017
- Author(s)
  Taguchi K, Yamasaki K, Sakai H, Maruyama T, Otagiri M
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 106 Pages: 2392-2400
- DOI
  10.1016/j.xphs.2017.04.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08261, KAKENHI-PROJECT-17K08481, KAKENHI-PROJECT-17H02087
[Journal Article] Artificial Red Blood Cells as Potential Photosensitizers in Dye Laser Treatment Against Port-Wine Stains (Review).2017
- Author(s)
  Rikihisa N, Watanabe S, Saito Y, Sakai H
- Journal Title
  
  Journal of Functional Biomaterials
  
  Volume: 8(2)
- DOI
  10.3390/jfb8020014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02087
[Journal Article] Hidden Antioxidative Functions of Reduced Nicotinamide Adenine Dinucleotide Coexisting with Hemoglobin.2017
- Author(s)
  Yamada M, Sakai H
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 12(7) Pages: 1820-1829
- DOI
  10.1021/acschembio.7b00174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H02087
[Journal Article] Potential New Non-Invasive Therapy Using Artificial Oxygen Carriers for Pre-Eclampsia (Review)2017
- Author(s)
  Ohta H, Kaga M, Li H, Sakai H, Okamura K, Yaegashi N
- Journal Title
  
  Journal of Functional Biomaterials
  
  Volume: 8(3)
- DOI
  10.3390/jfb8030032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02087
[Journal Article] Hemoglobin Vesicles prolong the time to circulatory collapse in rats during apnea2017
- Author(s)
  Naito Y, Sakai H, Inoue S, Kawaguchi M.
- Journal Title
  
  BMC Anesthesiology
  
  Volume: 17 Pages: 44-51
- DOI
  10.1186/s12871-017-0338-y
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K10521
[Journal Article] 人工赤血球(ヘモグロビンベシクル)の実現に向けて2015
- Author(s)
  酒井宏水、久禮智子
- Journal Title
  
  医学のあゆみ
  
  Volume: -
- Data Source
  KAKENHI-PROJECT-25282136
[Journal Article] Potential Electron Mediators to Extract Electron Energies of RBC Glycolysis for Prolonged in Vivo Functional Lifetime of Hemoglobin Vesicles2015
- Author(s)
  Karin Kettisen, Leif Bulow, and Hiromi Sakai
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 26 Pages: 746-754
- DOI
  10.1021/acs.bioconjchem.5b00076
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25282136
[Journal Article] 人工赤血球(ヘモグロビンベシクル)の実現に向けて2015
- Author(s)
  酒井宏水, 久禮智子
- Journal Title
  
  医学のあゆみ
  
  Volume: 253 Pages: 1180-1181
- Data Source
  KAKENHI-PROJECT-25282136
[Journal Article] Red Blood Cells Donate Electrons to Methylene-blue Mediated Chemical Reduction of Methemoglobin Compartmentalized in Liposomes in Blood.2014
- Author(s)
  Hiromi Sakai, Bing Li, Wei Lee Lim, Yumika Iga
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 25 Pages: 1301-1310
- DOI
  10.1021/bc500153x
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25282136
[Journal Article] Primary and secondary immune response to keyhole limpet hemocyanin in rats after infusion of hemoglobin vesicles, an artificial oxygen carrier2013
- Author(s)
  Fujihara M, Takahashi D, Abe, H, Sakai H, Horinouchi H, KObayashi K, Ikeda H, Azuma H
- Journal Title
  
  Artif Organs
  
  Volume: 38 Pages: 234-238
- DOI
  10.1111/aor.12148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461578
[Journal Article] Swine hemoglobin as a potential source of artificial oxygen carriers, hemoglobin-vesicles.2013
- Author(s)
  Hiromi Sakai
- Journal Title
  
  Artif. Cells Nanomedicine Biotechnol.
  
  Volume: 41 Pages: 37-41
- DOI
  10.3109/10731199.2012.716067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Cardiopulmonary hemodynamic responses to the small injection of hemoglobin-vesicles (artificial oxygen carriers) in miniature pigs2012
- Author(s)
  H. Sakai, Y. Suzuki, K. Sou, M. Kano
- Journal Title
  
  J. Biomed. Mater. Res. A
  
  Volume: 100 Pages: 2668-2677
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Fourteen-days observation and pharmacokinetic evaluation after massive intravenous infusion of hemoglobin-vesicles (artificial oxygen carriers) in cynomolgus monkeys.2012
- Author(s)
  K. Taguchi, H. Watanabe, H. Sakai, H. Horinouchi, K. Kobayashi, T. Maruyama, M. Otagiri
- Journal Title
  
  J. Drug Metab. Toxicol
  
  Volume: 3 Pages: 1000128-1000128
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Cellular-type hemoglobin-based oxygen carrier (hemoglobin-vesicles) as a transfusion alternative and for oxygen therapeutics2012
- Author(s)
  H. Sakai
- Journal Title
  
  Current Drug Discovery Techonl.
  
  Volume: 9 Pages: 188-193
- Data Source
  KAKENHI-PROJECT-24650301
[Journal Article] Effect of the cellular-type artificial oxygen carrier Hb-vesicle as a resuscitative fluid for pre-hospital treatment : Experiments in a rat uncontrolled hemorrhagic shock model.2012
- Author(s)
  Y. Seishi, H. Horinouchi, H. Sakai, K. Kobayashi
- Journal Title
  
  Shock
  
  Volume: 38 Pages: 153-158
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Removal of Hemoglobin-vesicles from circulating blood by using centrifugation and ultrafiltration.2012
- Author(s)
  H. Sakai, K. Sou, H. Horinouchi, E. Tsuchida, K. Kobayashi.
- Journal Title
  
  Artif. Organs
  
  Volume: 36 Pages: 202-209
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Physiolgical capacity of the reticuloendothelial system for the degradation of hemoglobin-vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusion for 7 days in Pregnant rats and fetuses.2012
- Author(s)
  M. Kaga, H. Ohta, Y. Lee, R. Kamii, H. Yamamoto, S. Akiyama, S. Watanabe, T. Matsuda, Y. Kimura, S. Tsuchiya, H. Tei, L. Okamura, H. Sakai, N. Yaegashi
- Journal Title
  
  Life Sci.
  
  Volume: 91 Pages: 420-428
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Fluid resuscitation of hemorrhagic shock with Hemoglobin vesicles in Beagle dogs : pilot study.2012
- Author(s)
  M. Yamamoto, H. Horinouchi, Y. Seishi, N. Sato, M. Itoh, K. Kobayashi, H. Sakai
- Journal Title
  
  Artif. Cells Blood Substitutes Biotechnol
  
  Volume: 40 Pages: 179-195
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Cellular-type hemoglobin-based oxygen carrier (hemoglobin-vesicles) as a transfusion alternative and for oxygen therapeutics2012
- Author(s)
  Hiromi Sakai
- Journal Title
  
  Current Drug Discovery Techonl.
  
  Volume: 9 Pages: 188-193
- DOI
  10.2174/157016312802650805
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Protein-protein interactions in solution and their interplay with protein specific functions2012
- Author(s)
  T. Sato, T. Fukasawa, T. Komatsu, H. Sakai, S. Ishiwata
- Journal Title
  
  J. Phys. Soc. Jpn
  
  Volume: 81
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Fluid resuscitation of hemorrhagic shock with Hemoglobin vesicles in Beagle dogs : pilot study2012
- Author(s)
  M.Yamamoto, H.Horinouchi, Y.Seishi, K.Kobayashi, H.Sakai, et al
- Journal Title
  
  Artif.Cells Blood Substitutes Biotechnol
  
  Volume: 40 Pages: 179-195
- DOI
  10.3109/10731199.2011.637929
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Microcirculation and NO-CO studies of a natural extracellular hemoglobin developed for an oxygen therapeutic carrier2012
- Author(s)
  A.G. Tsai, M. Intaglietta, H. Sakai, E. Delpy, C.D. la Rochelle, M. Rousselot, F. Zal
- Journal Title
  
  Current Drug Discovery Techonl.
  
  Volume: 9 Pages: 166-172
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Hemoglobin vesicle as an effective blood substitute and its removal from circulating blood2012
- Author(s)
  H.Sakai, K.Sou, H.Horinouchi, E.Tsuchida, K.Kobayashi
- Journal Title
  
  Artificial Organs
  
  Volume: 36 Pages: 202-209
- DOI
  10.1111/j.1525-1594.2011.01236.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Cellular-type hemoglobin-based oxygen carrier (hemoglobin-vesicles) as a transfusion alternative and for oxygen therapeutics2012
- Author(s)
  H. Sakai
- Journal Title
  
  Curr. Drug Discovery Techonl
  
  Volume: 9 Pages: 188-193
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] An automated method for cell-free layer width determination in small arterioles.2011
- Author(s)
  P.K. Ong, S. Jain, B. Namgung, Y.I. Woo, H. Sakai, D. Lim, K.J. Chun, S. Kim
- Journal Title
  
  Physiol. Meas
  
  Volume: 32
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Intravenous injection of Hb-vesicles (artificial oxygen carriers) after hemodilution with a series of plasma expanders (water-soluble biopolymers) in a rat repeated hemorrhage model.2011
- Author(s)
  H. Sakai, N. Miyagawa, H. Horinouchi, S. Takeoka, M. Takaori, E. Tsuchida, K. Kobayashi
- Journal Title
  
  Polymers Adv. Technol.
  
  Volume: 22 Pages: 1216-1222
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Fluid resuscitation with hemoglobin vesicles prevents Esherichia coli growth via complement activation in a hemorrhagic shock rat model.2011
- Author(s)
  K. Taguchi, S. Ogaki, H. Watanabe, D. Kadowaki, H. Sakai, K. Kobayashi, H. Horinouchi, T. Maruyama, M. Otagiri
- Journal Title
  
  J. Pharmacol. Exp. Therap
  
  Volume: 337 Pages: 201-208
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Phagocytosis of liposome particles by rat splenic immature monocytes makes them transiently and highly immunosuppressive in ex vivo culture condition.2011
- Author(s)
  D. Takahashi, H. Azuma, H. Sakai, K. Sou, D. Wakita, H. Abe, M. Fujihara, H. Horinouchi, K. Kobayashi, T. Nishimura, H. Ikeda.
- Journal Title
  
  J. Pharmacol. Exp. Therap
  
  Volume: 337 Pages: 42-49
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] What is the major mechanism of slower NO uptake by red blood cells? (Letter to Editorial)2011
- Author(s)
  H. Sakai
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 286
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Gas bioengineering using hemoglobin-vesicles for versatile clinical application2011
- Author(s)
  H. Sakai, S. Takeoka, K. Kobayashi
- Journal Title
  
  Curr. Pharmaceut. Design
  
  Volume: 17 Pages: 2352-2359
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Alteration in the pharmacokinetics of hemoglobin-vesicles in a rat model of chronic liver cirrhosis is associated with Kupffer cell phagocyte activity.2011
- Author(s)
  K. Taguchi, M. Miyasato, H. Watanabe, H. Sakai, H. Horinouchi, K. Kobayashi, E. Tsuchida, T. Maruyama, M. Otagiri
- Journal Title
  
  J. Pharmaceut. Sci.
  
  Volume: 100 Pages: 775-783
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Intravenous injection of Hb-vesicles after hemodilution with a series of plasma expanders (water-soluble biopolymers) in a rat repeated hemorrhage model2011
- Author(s)
  H.Sakai, N.Miyagawa, H.Horinouchi, S.Takeoka, M.Takaori, et al
- Journal Title
  
  Polymers Adv.Technol.
  
  Volume: 22 Pages: 1216-1222
- DOI
  10.1002/pat.1964
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Cellular-type hemoglobin-based oxygen carrier (hemoglobin-vesicles) as a transfusion alternative and for oxygen therapeutics.2011
- Author(s)
  H.Sakai
- Journal Title
  
  Current Drug Discovery Techonl
  
  Volume: (発行予定) Pages: 364-364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Increased viscosity of hemoglobin-based oxygen carriers retards NO-binding when perfused through narrow gas-permeable tubes2011
- Author(s)
  H. Sakai, N. Okuda, S. Takeoka, E. Tsuchida
- Journal Title
  
  Microvasc. Res.
  
  Volume: 81 Pages: 169-176
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Repeated injection of high dose of hemoglobin encapsulated liposomes (hemoglobin-vesicles) induces accelerated blood clearance in a hemorrhagic shock rat model.2011
- Author(s)
  K. Taguchi, Y. Iwao, H. Watanabe, D. Kadowaki, H. Sakai, K. Kobayashi, H. Horinouchi, T. Maruyama, M. Otagiri
- Journal Title
  
  Drug Metab. Dispos
  
  Volume: 39 Pages: 484-489
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Hepatically-metabolized and .excreted artificial oxygen carrier, hemoglobin-vesicles, can be safely used under conditions of hepatic impairment.2010
- Author(s)
  K. Taguchi, M. Miyasato, H. Ujihara, H. Watanabe, D. Kadowaki, H. Sakai, E. Tsuchida, H. Horinouchi, K. Kobayashi, T. Maruyama, M. Otagiri
- Journal Title
  
  Toxicol. Appl. Pharmacol.
  
  Volume: 248 Pages: 234-241
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Hemoglobin-vesicle, a cellular artificial oxygen carrier, that fulfils the physiological roles of the red blood cells structure2010
- Author(s)
  H.Sakai, K.Sou, H.Horinouchi, K.Kobayashi, E.Tsuchida
- Journal Title
  
  Adv.Exp.Med.Biol. 662
  
  Pages: 433-438
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Increased viscosity of hemoglobin-based oxygen carriers retards NO-binding when perfused through narrow gas-permeable tubes2010
- Author(s)
  H.Sakai, N.Okuda, S.Takeoka, E.Tsuchida
- Journal Title
  
  Microvasc.Res.
  
  Volume: 81 Pages: 169-176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Measurement of electrolyte concentrations in serum containing liposome vesicles2010
- Author(s)
  Miyake, J. Takemura, H. Sakai, M. Takaori
- Journal Title
  
  Artif. Blood
  
  Volume: 18 Pages: 91-95
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Hemoglobin encapsulation in vesicles retards NO-and CO-bindings and O2-release when perfused through narrow gas-permeable tubes.2010
- Author(s)
  H. Sakai, N. Okuda, A. Sato, S. Takeoka, E. Tsuchida.
- Journal Title
  
  Am. J. Physiol. Heart Circ. Physiol. 298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Effects of crystalloid and colloid osmotic pressure on HbV (liposome encapsulated hemoglobin) membrane.2010
- Author(s)
  Miyake, H. Sakai, M. Takaori
- Journal Title
  
  Artif. Blood
  
  Volume: 18 Pages: 128-133
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Hemoglobin encapsulation in vesicles retards NO- and CO-bindings and O2-release when perfused throughnarrow gas-permeable tubes2010
- Author(s)
  H.Sakai, N.Okuda, A.Sato, S.Takeoka, E.Tsuchida.
- Journal Title
  
  Am.J.Physiol.Heart Circ.Physiol. 298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Hemoglobin-vesicle, a cellular artificial oxygen carrier, that fulfils the physiological roles of the red blood cells structure.2010
- Author(s)
  H. Sakai, K. Sou, H. Horinouchi, K. Kobayashi, E. Tsuchida
- Journal Title
  
  Adv. Exp. Med. Biol.
  
  Volume: 662 Pages: 433-438
- Data Source
  KAKENHI-PROJECT-22300161
[Journal Article] Static structure and dynamics of hemoglobin vesicles (HbV) developed as a transfusion alternative2009
- Author(s)
  T. Sato, H. Sakai, K. Sou, O. Glatter, E. Tsuchida.
- Journal Title
  
  J. Phys. Chem. B. 113
  
  Pages: 8418-8428
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] 人工赤血球の過去、現在、未来2009
- Author(s)
  酒井宏水, 土田英俊
- Journal Title
  
  ファルマシア 45
  
  Pages: 23-28
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Histopathological changes of rat brain after direct injection of hemoglobin-vesicles (oxygen carriers) and neurological impact in an intracerebral hemorrhage model2009
- Author(s)
  H. Sakai, M. Okamoto, E. Ikeda, H. Horinouchi, K. Kobayashi, E. Tsuchida.
- Journal Title
  
  J. Biomed. Mater. Res. 90A
  
  Pages: 1107-1119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Artificial oxygen carriers, hemoglobin vesicles and albumin-hemes, based on bioconjugate chemistry2009
- Author(s)
  E.Tsuchida, K.Sou, A.Nakagawa, H.Sakai, T.Komatsu, K.Kobayashi.
- Journal Title
  
  Bioconjugate Chem. 20
  
  Pages: 1419-1440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Hemoglobin vesicles as a transfusion alternative2009
- Author(s)
  H.Sakai, K.Sou, E.Tsuchida.
- Journal Title
  
  Methods Enzymol. 465(Liposomes Part G)
  
  Pages: 363-384
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Fluid resuscitation with artificial oxygen carriers in hemorrhaged rats: Profiles of Hb-vesicles degradation and hematopoiesis for 14 days2009
- Author(s)
  H. Sakai, Y. Seishi, Y. Obata, S. Takeoka, H. Horinouchi, E. Tsuchida, K. Kobayashi.
- Journal Title
  
  Shock 31
  
  Pages: 192-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] ヘモグロビン小胞体を含有する血液検体の臨床検査2009
- Author(s)
  宗慶太郎, 小峰梨沙, 酒井宏水, 小林紘一, 土田英俊, 村田満
- Journal Title
  
  人工血液 17
  
  Pages: 6-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Mechanism of flocculate formation of highly concentrated phospholipid vesicles suspended in a series of water-soluble biopolymers2009
- Author(s)
  H.Sakai, A.Sato, S.Takeoka, E.Tsuchida
- Journal Title
  
  Biomacromolecules 10
  
  Pages: 2344-2350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Hemoglobin-vesicles and red blood cells as carriers of carbon monoxide prior to oxygen for resuscitation after hemorrhagic shock in a rat model2009
- Author(s)
  H.Sakai, H.Horinouchi, K.Kobayashi, E.Tsuchida
- Journal Title
  
  Shock 31
  
  Pages: 507-514
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Systemic administration of hemoglobin vesicles elevates tumor tissue oxygen tension and modifies tumorresponse to irradiation.2009
- Author(s)
  M. Yamamoto, Y. Izumi, H. Horinouohi, Y. Teramura, H. Sakai, et al.
- Journal Title
  
  J. Surg. Res. 151
  
  Pages: 48-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Peculiar flow patterns of RBCs suspended in viscous fluids and perfused through a narrow tube (25μm).2009
- Author(s)
  H. Sakai, A. Sato, N. Okuda, S. Takeoka, N. Maeda, E. Tsuchida
- Journal Title
  
  Am. J. Physiol. Heart Circ. Physiol. 297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Mechanism of flocculate formation of highly concentrated phospholipid vesicles suspended in a series of water-soluble biopolymers.2009
- Author(s)
  H. Sakai, A. Sato, S. Takeoka, E. Tsuchida.
- Journal Title
  
  Biomacromolecules 10
  
  Pages: 2344-2350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Effects of hemoglobin vesicles, a cellular-type artificial oxygen carrier, on human hematopoietic stem/progenitor eells in vitro.2009
- Author(s)
  M. Yamaguohi, M. Fujihara, S. Wakamoto, H. Sakai, et al.
- Journal Title
  
  J. Biomed. Materials Res. 88A
  
  Pages: 34-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Peculiar flow patterns of RBCs suspended in viscous fluids and perfused through a narrow tube(25 micrometer)2009
- Author(s)
  H.Sakai, A.Sato, N.Okuda, S.Takeoka, N.Maeda, E.Tsuchida
- Journal Title
  
  Am.J.Physiol.Heart Circ.Physiol. 297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Hemoglobin vesicles improve wound healing and tissue survival in critically ischemic murine skin.2009
- Author(s)
  J.A. Plock, N. Rafatmehr, D. Sinovcic, Y. Harder, H. Sakai, E. Tsuchida, A. Banic, D. Erni.
- Journal Title
  
  Am. J. Physiol. Heart Circ. Physiol. 297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Review of hemoglobin-vesioles as artificial oxygen carriers2009
- Author(s)
  H. Sakai, K. Sou, H. Horinouohi, K. Kobayashi, E. Tsuchida
- Journal Title
  
  Artif. Organs 33
  
  Pages: 139-145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Static structure and dynamics of hemoglobin vesicles(HbV)developed as a transfusion alternative2009
- Author(s)
  T.Sato, H.Sakai, K.Sou, O.Glatter, E.Tsuchida.
- Journal Title
  
  J.Phys.Chem.B. 113
  
  Pages: 8418-8428
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Fluid resuscitation with artificial oxygen carriers in hemorrhaged Rats : Profiles of Hb-vesicles degradation and hematopoiesis for 14 days.2009
- Author(s)
  H. Sakai, Y. Seishi, Y. Obata, et al.
- Journal Title
  
  Shock 31
  
  Pages: 192-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Hemoglobin-vesicles and red blood cells as carriers of carbon monoxide prior to oxygen for resuscitation after hemorrhagic shock in a rat model2009
- Author(s)
  H. Sakai, H. Horinouchi, K. Kobayashi, E. Tsuchida.
- Journal Title
  
  Shock 31
  
  Pages: 507-514
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] 多波長パルス分光法を用いたHb小胞体用パルスオキシメータに関する研究.2008
- Author(s)
  須崎裕典, 酒井宏水, 小林直樹, 池田達彦, 堀之内宏久, ほか.
- Journal Title
  
  人工血液 16
  
  Pages: 198-204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Encapsulation of concentrated hemoglobin solution in phospholipid vesicles retards the reaction with NO, but not CO, by intracellular diffusion barrier2008
- Author(s)
  H. Sakai, A. Sato, K. Masuda, S. Takeoka, E. Tsuchida.
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 1508-1517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] NO and CO binding profiles of hemoglobin vesicles as artificial oxygen carriers.2008
- Author(s)
  H. Sakai, A. Sato, P. Sobolewski, et al.
- Journal Title
  
  Biochlm. Biophys. Acta 1784
  
  Pages: 1441-1447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Encapsulation of concentrated hemoglobin solution in phospholipid vesicles retards the reaction with NO, but not CO,by intracellular diffusion barrier.2008
- Author(s)
  H.Sakai, A.Sato, K.Masuda, S.Takeoka, E.Tsuchida.
- Journal Title
  
  J.Biol.Chem. 283
  
  Pages: 1508-1517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] The role of luminal factors in the recovery of gastric functions and behavioral changes after chronic Helioobacter pylori infection.2008
- Author(s)
  E. F. Verdu, P. Beroik, H. Sakai, E. Tsuchida, S. M. Collins, et al.
- Journal Title
  
  Am. J. Physiol. Gastrointest. Liver Physiol. 295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Hemoglobin-vesicles as artificial oxygen carriers:Present situation and future vision.2008
- Author(s)
  H.Sakai, K.Sou, H.Horinouchi, K.Kobayashi, E.Tsuchida.
- Journal Title
  
  J.Intern.Med 263
  
  Pages: 4-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] The role of luminal factors in the recovery of gastric functions and behavioral changes after chronic Helicobacter pylori infection.2008
- Author(s)
  E.F. Verdu, P. Bercik, X.X. Huang, J. Lu, N. Al-Mutawaly, H. Sakai, T.A. Tompkins, K. Croitoru, E. Tsuchida, M. Prude, S.M. Collins.
- Journal Title
  
  Am. J. Physiol. Gastrointest. Liver Physiol. 295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Hemoglobin-vesicles as artificial oxygen carriers: Present situation and future vision.2008
- Author(s)
  H. Sakai, K. Sou, H. Horinouchi, K. Kobayashi, E. Tsuchida.
- Journal Title
  
  J. Intern. Med. 263
  
  Pages: 4-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] NO and CO binding profiles of hemoglobin vesicles as artificial oxygen carriers.2008
- Author(s)
  H. Sakai, A. Sato, P. Sobolewski, S. Takeoka, J.A. Frangos, K. Kobayashi, M. Intaglietta, E. Tsuchida.
- Journal Title
  
  Biochim. Biophys. Acta 1784
  
  Pages: 1441-1447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] 各種代用血漿剤に分散させたヘモグロビン小胞体(人工赤血球)とその血液混合系のレオロジー特性2007
- Author(s)
  佐藤敦、酒井宏水、武岡真司、土田英俊
- Journal Title
  
  日本ヘモレオロジー学会誌 10
  
  Pages: 3-11
- NAID
  40016055324
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Rheological properties of hemoglobin vesicles (artificial oxygen carriers) suspended in a series of plasma substitute solutions2007
- Author(s)
  H. Sakai, A. Sato, S. Takeoka, E. Tsuchida
- Journal Title
  
  Langmuir 23
  
  Pages: 8121-8128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] One-year observation of Wistar rats after infusion of Hb-vesicles (Artificial oxygen carriers).2007
- Author(s)
  H.Sakai, H.Horinouchi, E.Tsuchida, K.Kobayashi
- Journal Title
  
  Artif. Cells Blood Substitutes Biotechnol. 35
  
  Pages: 81-91
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Molecular to cooperative dynamics and static structures of PEG-conjugated phospholipid in aqueous micellar solutions : dielectric spectroscopy and SAXS study.2007
- Author(s)
  T.Satoh, H.Sakai, K.Sou, E.Tsuchida
- Journal Title
  
  J. Phys. Chem. B. 11
  
  Pages: 1393-1401
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Hemoglobin-vesicles for a Transfusion Alternative and Targeted Oxygen Delivery.2007
- Author(s)
  H.Sakai, E.Tsuchida.
- Journal Title
  
  J.Liposome Res. 17
  
  Pages: 227-235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] 輸血の代替が可能な酸素輸液の実現と組織再生技術2007
- Author(s)
  酒井宏水、土田英俊
- Journal Title
  
  環境と健康 20
  
  Pages: 464-472
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Solution to the Problems of acellular Hbs by encapsulation, and the intrinsic issues of Hb-vesicles as a molecular assembly.2007
- Author(s)
  H.Sakai, K.Sou, E.Tsuchida.
- Journal Title
  
  Transfusion Alternatives in Transfusion Medicine 9
  
  Pages: 226-236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Hemoglobin vesicles reduce hypoxia-related inflammation in critically ischemic hamster flap tissue.2007
- Author(s)
  J.Plock, A.E.Tromp, C.Contaldo, T.Spanholtz, D.Sinovcic, H.Sakai, E.Tsuchida, M.Leunig, A.Banic, D.Erni
- Journal Title
  
  Crit.Care Med. 35
  
  Pages: 899-905
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] phospholipid in aqueous micellar solutions : dielectric spectroscopy and SAXS study.2007
- Author(s)
  T.Satoh, H.Sakai, K.Sou, E.Tsuchida.
- Journal Title
  
  J.Phys.Chem.B. 11
  
  Pages: 1393-1401
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Effects of hemoglobin vesicles,a liposomal artificial oxygen carrier,on hematological responses,complement and anaphylactic reactions in rats.2007
- Author(s)
  Abe H, Azuma H, Ikeda H, Sakai H, Takeoka S, Tsuchida E, et. al.
- Journal Title
  
  Artif.Cells Blood Substitutes Biotechnol. 35
  
  Pages: 157-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Hemoglobin vesicles reduce hypoxia-related inflammation in critically ischemic hamster flap tissue.2007
- Author(s)
  J.Plock, A.E.Tromp, C.Contaldo, H.Sakai, D.Erni, et al.
- Journal Title
  
  Crit Care Med. 35
  
  Pages: 899-905
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Hemoglobin vesicles reduce hypoxia-related inflammation in critically ischemic hamster flap tissue.2007
- Author(s)
  J.Plock, A.E.Tromp, C.Contaldo, T.Spanholtz, D.Sinovcic, H.Sakai, E.Tsuchida, M.Leunig, A.Banic, D.Erni
- Journal Title
  
  Crit Care Med. 35
  
  Pages: 899-905
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Effects of hemoglobin vesicles, a liposomal artificial oxygen carrier, on hematological responses, complement and anaphylactic reactions in rats.2007
- Author(s)
  H.Abe, H.Azuma, M.Yamaguchi, M.Fujihara, H.Sakai, S.Takeoka, E.Tsuchida, H.Ikeda
- Journal Title
  
  Artif. Cells Blood Substitutes Biotechnol. (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] モグロビン小胞体(HbV)-リコンビナントアルブミン分散溶液による40%交換輸血 : ラット脾臓内HbV代謝と造血に関する2週間の観察(二次掲載)2007
- Author(s)
  酒井宏水, 堀之内宏久, 山本学, 池田栄二, ほか
- Journal Title
  
  日本輸血細胞治療学会誌 53
  
  Pages: 47-55
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Effects of hemoglobin vesicles, a liposomal artificial oxygen carrier, on hematological responses, complement and anaphylactic reactions in rats.2007
- Author(s)
  H.Abe, H.Azuma, M.Yamaguchi, M.Fujihara, H.Sakai, S.Takeoka, E.Tsuchida, H.Ikeda.
- Journal Title
  
  Artif.Cells Blood Substitutes Biotechnol. (in press.)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] ヘモグロビン小胞体(HbV)-リコンビナントアルブミン分散溶液による40%交換輸血 : ラット脾臓内HbV代謝と造血に関する2週間の観察(論文記事 : secondary publication).2007
- Author(s)
  酒井宏水, 堀之内宏久, 山本学, 池田栄二, 武岡真司, 高折益彦, 土田英俊, 小林紘一
- Journal Title
  
  日本輸血細胞治療学会誌 53
  
  Pages: 47-55
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] One-year observation of Wistar rats after infusion of Hb-vesicles (Artificial oxygen carriers).2007
- Author(s)
  H.Sakai, H.Horinouchi, E.Tsuchida, K.Kobayashi.
- Journal Title
  
  Artif. Cells Blood Substitutes Biotechnol. 35(in press)
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Rheological properties of hemoglobin vesicles(artificial oxygen carriers)suspended in a series of plasma substitute solutions.2007
- Author(s)
  Sakai H, Sato A, Takeoka S, Tsuchida E.
- Journal Title
  
  Langmuir 23
  
  Pages: 8121-8128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300164
[Journal Article] Molecular to cooperative dynamics and static structures of PEG-conjugated phospholipid in aqueous micellar solutions : dielectric spectroscopy and SAXS study.2007
- Author(s)
  T.Satoh, H.Sakai, K.Sou, E.Tsuchida.
- Journal Title
  
  J.Phys.Chem.B. 11
  
  Pages: 1393-1401
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Effects of hemoglobin vesicles, a liposomal artificial oxygen carrier, on hematological responses, complement and anaphylactric reactions in rats.2007
- Author(s)
  H.Abe, H.Azuma, M.Fujihara, H.Sakai, H.Ikeda, et al.
- Journal Title
  
  Artif. Cells Blood Substitutes Biotechnol. 34(in press)
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] One-year observation of Wistar rats after infusion of Hb-vesicles (Artificial oxygen carriers).2007
- Author(s)
  H.Sakai, H.Horinouchi, E.Tsuchida, K.Kobayashi.
- Journal Title
  
  Artif.Cells Blood Substitutes Biotechnol. 35
  
  Pages: 81-91
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Performances of PEG-modified hemoglobin-vesicles as artificial oxygen carriers in microcirculation.2006
- Author(s)
  H.Sakai, E.Tsuchida
- Journal Title
  
  Clin. Hemorheol. Microcirc. 34
  
  Pages: 35-340
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Hemoglobin vesicles containing methemoglobin and L-tyrosine to suppress methemoglobin formation in vitro and in vivo.2006
- Author(s)
  T.Atoji, M.Aihara, H.Sakai, E.Tsuchida, S.Takeoka.
- Journal Title
  
  Bioconjugate Chem. 17
  
  Pages: 1241-1245
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Fluid resuscitation with hemoglobin-vesicle solution does not increase hypoxia or inflammatory responses in moderate hemorrhagic shock.2006
- Author(s)
  Y.Goto, K.Terajima, T.Tsueshita, M.Miyashita, H.Horinouchi, H.Sakai, E.Tsuchida, A.Sakamoto.
- Journal Title
  
  Biomed.Res. 27
  
  Pages: 283-288
- NAID
  130004470673
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Performances of PEG-modified hemoglobin-vesicles as artificial oxygen carriers in microcirculation.2006
- Author(s)
  H.Sakai, E.Tsuchida.
- Journal Title
  
  Clin.Hemorheol.Microcirc. 34
  
  Pages: 335-340
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Blood Substitutes2006
- Author(s)
  H.Sakai, E.Tsuchida.
- Journal Title
  
  Wiley Encyclopedia of Biomedical Engineering.(M.Akay (Ed.))(John Wiley ＆ Sons, Inc., Hoboken, NJ.)
  
  Pages: 613-621
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Acute 40 percent exchange-transfusion with hemoglobin-vesicles (HbV) suspended in recombinant human serum albumin solution : degradation of HbV and erythropoiesis in a rat spleen for 2 weeks.2006
- Author(s)
  H.Sakai, H.Horinouchi, M.Yamamoto, E.Ikeda, S.Takeoka, M.Takaori, E.Tsuchida, K.Kobayashi
- Journal Title
  
  Transfusion 46
  
  Pages: 339-347
- NAID
  120001107019
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Blood Substitutes' Efficacy : Microvascular and Theological Determinants.2006
- Author(s)
  A.G.Tsai, P.Cabrales, H.Sakai, M.Intaglietta.
- Journal Title
  
  Microvascular Research : Biology and Pathology, (Ed: David Shepro)(San Diego: Elsevier) Vol.2
  
  Pages: 1095-1103
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Hemoglobin vesicles containing methemoglobin and L-tyrosine to suppress methemoglobin formation in vitro and in vivo.2006
- Author(s)
  T.Atoji, M.Aihara, H.Sakai, E.Tsuchida, S.Takeoka
- Journal Title
  
  Bioconjugate Chem. 17
  
  Pages: 1241-1245
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Fluid resuscitation with hemoglobin-vesicle solution does not increase hypoxia or inflammatory responses in moderate hemorrhagic shock.2006
- Author(s)
  Y.Goto, K.Terajima, T.Tsueshita, M.Miyashita, H.Sakai, et al.
- Journal Title
  
  Biomed.Res. 27
  
  Pages: 283-288
- NAID
  130004470673
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Hemoglobin-vesicles as a transfusion alternative.2006
- Author(s)
  E.Tsuchida, H.Sakai, H.Horinouchi, K.Kobayashi.
- Journal Title
  
  Artif.Cells Blood Substitutes Biotechnol. 34
  
  Pages: 581-588
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] recombinant human serum albumin solution : Degradation of HbV and erythropoiesis in rat spleen for 2 Weeks.2006
- Author(s)
  Sakai H, Horinouchi H, Yamamoto M, Ikeda E, et al.
- Journal Title
  
  Transfusion 46
  
  Pages: 339-347
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] suspended in recombinant human serum albumin solution : degradation of HbV and erythropoiesis in a rat spleen for 2 weeks.2006
- Author(s)
  H.Sakai, H.Horinouchi, M.Yamamoto, E.Ikeda et al.
- Journal Title
  
  Transfusion 46
  
  Pages: 339-347
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Hemoglobin-vesicles as a transfusion alternative.2006
- Author(s)
  E.Tsuchida, H.Sakai, H.Horinouchi, K.Kobayashi
- Journal Title
  
  Artif. Cells Blood Substitutes Biotechnol. 34
  
  Pages: 581-588
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Acute 40 percent exchange-transfusion with hemoglobin-vesicles (HbV) suspended in recombinant human serum albumin solution : degradation of HbV and erythropoiesis in a rat spleen for 2 weeks.2006
- Author(s)
  H.Sakai, H.Horinouchi, M.Yamamoto, E.Ikeda, S.Takeoka, M.Takaori, E.Tsuchida, K.Kobayashi.
- Journal Title
  
  Transfusion 46
  
  Pages: 339-347
- NAID
  120001107019
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Hemoglobin-Vesicles as a Molecular Assembly : Characteristics of Preparation Process and Performances as Artificial Oxygen Carriers.2006
- Author(s)
  H.Sakai, K.Sou, S.Takeoka, K.Kobayashi, E.Tsuchida
- Journal Title
  
  Blood Substitutes (Ed.By Robert M.Winslow, Elsevier)(Chapt.) 44
  
  Pages: 514-522
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Fluid resuscitation with hemoglobin-vesicle solution does not increase hypoxia or inflammatory responses in moderate hemorrhagic shock.2006
- Author(s)
  Y.Goto, K.Terajima, T.Tsueshita, M.Miyashita, H.Horinouchi, H.Sakai, E.Tsuchida, A.Sakamoto
- Journal Title
  
  Biomed. Res. 27
  
  Pages: 283-288
- NAID
  130004470673
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] New generation of hemoglobin-based oxygen carriers evaluated for oxygenation of critically ischemic hamster flap tissue.2005
- Author(s)
  C.Contaldo, J.Plock, H.Sakai, S.Takeoka, E.Tsuchida, M.Leuing, A.Banic, D.Erni
- Journal Title
  
  Crit. Care Med. 33
  
  Pages: 806-812
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] 海外文献紹介"P_<50>値の低いヘモグロビンによる酸素ターゲッティング : 酸素治療の新しい原理".2005
- Author(s)
  酒井宏水, 土田英俊
- Journal Title
  
  人工血液 13
  
  Pages: 122-127
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] 目でみるバイオ「微小血管内を均一に流れる人工赤血球とその運命」2005
- Author(s)
  酒井宏水, 土田英俊
- Journal Title
  
  バイオサイエンスとインダストリー 63
  
  Pages: 571-572
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Is the Hb in Hb-vesicles infused for isovolemic hemodilution necessary to improve oxygenation in critically ischemic hamster skin?2005
- Author(s)
  Plock JA, Contaldo C, Sakai H, Tsuchida E, Erni D, et al.
- Journal Title
  
  Am.J.Physiol.Heart Circ.Physiol 289
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] New generation of hemoglobin-based oxygen carriers evaluated for oxygenation of critically ischemic hamster flap tissue.2005
- Author(s)
  C.Contaldo, J.Plock, H.Sakai, S.Takeoka, E.Tsuchida, M.Leuing, A.Banic, D.Erni.
- Journal Title
  
  Crit.Care Med. 33
  
  Pages: 806-812
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Oxygen Release from low and normal P_<50> Hb-vesicles in Transiently Occluded Arterioles of the Hamster Window Model.2005
- Author(s)
  H.Sakai, P.Cabrales, A.G.Tsai, M.Intaglietta, E.Tsuchida.
- Journal Title
  
  Am.J.Physiol.Heart Circ.Physiol. 288
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Safety and Efficacy of Hemoglobin-Vesicles and Albumin-Hemes.2005
- Author(s)
  K.Kobayashi, H.Horinouchi, M.Watanabe, Y.Izumi, Y.Teramura, A.Nakagawa, Y.Huang, K.Sou, H.Sakai, T.Komatsu, S.Takeoka, E.Tsuchida.
- Journal Title
  
  Artificial Oxygen Carrier : Its Front Line, Keio University International Symposia for Life Sciences and Medicine(Eds.by K.Kobayashi, E.Tsuchida, H.Horinouchi.)(Springer-Verlag) Vol.12
  
  Pages: 1-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Hemoglobin-vesicles (HbV) as Artificial Oxygen Carriers.2005
- Author(s)
  H.Sakai, K.Sou, S.Takeoka, K.Kobayashi, E.Tsuchida.
- Journal Title
  
  Artificial Oxygen Carrier : Its Front Line, Keio University International Symposia for Life Sciences and Medicine(Eds.by K.Kobayashi, E.Tsuchida, H.Horinouchi)(Springer-Verlag) Vol.12
  
  Pages: 135-168
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] 目でみるバイオ「微小血管内を均一に流れる人工赤血球とその運命」2005
- Author(s)
  酒井宏水, 土田英俊
- Journal Title
  
  バイオナイエンスとインダスハノー 63
  
  Pages: 571-572
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] New generation of hemoglobin-based oxygen carriers evaluated for oxygenation of critically ischemic hamster flap tissue.2005
- Author(s)
  Contaldo C, Plock J, Sakai H, Takeoka S, Tsuchida E, Banic A, Erni D
- Journal Title
  
  Crit.Care Med. 33
  
  Pages: 806-812
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] 海外文献紹介"P50値の低いヘモグロビンによる酸素ターゲッティング・酸素治療の新しい原理".2005
- Author(s)
  酒井宏水, 土田英俊
- Journal Title
  
  人工血液 13
  
  Pages: 122-127
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Is the Hb in Hb-vesicles infused for isovolemic hemodilution necessary to improve oxygenation in critically ischemic hamster skin?2005
- Author(s)
  J.A.Plock, C.Contaldo, H.Sakai, E.Tsuchida, M.Leunig, A.Banic, M.D.Menger, D.Erni.
- Journal Title
  
  Am.J.Physiol.Heart Circ. Physiol 289
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Is the Hb in Hb-vesicles infused for isovolemic hemodilution necessary to improve oxygenation in critically ischemic hamster skin?2005
- Author(s)
  J.A.Plock, C.Contaldo, H.Sakai, E.Tsuchida, M.Leunig, A.Banic, M.D.Menger, D.Erni
- Journal Title
  
  Am. J. Physiol. Heart Circ. Physiol 289
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Oxygen Infusions (Hemoglobin-Vesicles and Albumin-Hemes) Based on Nano-Molecular Sciences. (Review)2005
- Author(s)
  Tsuchida E, Sakai H, Komatsu T, et al.
- Journal Title
  
  Polymers Adv.Technol. 16
  
  Pages: 73-83
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Oxygen Release from low and normal P50 Hb-vesicles from Transiently Occluded Arteriole in the Hamster Window Model.2005
- Author(s)
  Sakai H, Cabrales P, Tsai AG, Intaglietta M, Tsuchida E.
- Journal Title
  
  Am.J.Physiol.Heart Circ.Physiol. 288
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Oxygen Release from low and normal P_<50> Hb-vesicles in Transiently Occluded Arterioles of the Hamster Window Model.2005
- Author(s)
  H.Sakai, P.Cabrales, A.G.Tsai, M.Intaglietta, E.Tsuchida
- Journal Title
  
  Am. J. Physiol. Heart Circ. Physiol. 288
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Oxygen Infusions (Hemoglobin-Vesicles and Albumin-Hemes) Based on Nano-Molecular Sciences.2005
- Author(s)
  E.Tsuchida, H.Sakai, T.Komatsu, S.Takeoka, Y.Huang, K.Sou, A.Nakagawa, Y.Teramura, K.Kobayashi
- Journal Title
  
  Polymers Adv. Technol. 16
  
  Pages: 73-83
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Oxygen transport by low and normal P50 Hb-vesicles in extreme hemodilution.2005
- Author(s)
  Cabrales P, Sakai H, Tsai AG, Takeoka S, Tsuchida E, Intaglietta M.
- Journal Title
  
  Am.J.Physiol.Heart Circ.Physiol 288
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Oxygen Infusions (Hemoglobin-Vesicles and Albumin-Hemes) Based on Nano-Molecular Sciences.2005
- Author(s)
  E.Tsuchida, H.Sakai, T.Komatsu, S.Takeoka, Y.Huang, K.Sou, A.Nakagawa, Y.Teramura, K.Kobayashi.
- Journal Title
  
  Polymers Adv.Technol. 16
  
  Pages: 73-83
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Oxygen transport by low and normal P_<50> Hb-vesicles in extreme hemodilution.2005
- Author(s)
  P.Cabrales, H.Sakai, A.G.Tsai, S.Takeoka, E.Tsuchida, M.Intaglietta.
- Journal Title
  
  Am.J.Physiol.Heart Circ.Physiol 288
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Hemorrhagic shock resuscitation with an artificial O2 carrier HbV maintains intestinal perfusion and suppresses the increase in plasma TNFα.2004
- Author(s)
  Yoshizu A, Izumi Y, Park S, Sakai H, Takeoka S, Horinouchi H, et al.
- Journal Title
  
  ASAIO J. 50
  
  Pages: 458-463
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] An effective blood substitutes that targets oxygen delivery, increases plasma viscosity, and has high oxygen affinity.2004
- Author(s)
  Tsai AG, Sakai H, Wettstein R, Kerger H, Intaglietta M
- Journal Title
  
  TATM : Transfusion Alternatives in Transfusion Medicine 5
  
  Pages: 507-513
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Oxygen transport by low and normal P_<50> Hb-vesicles in extreme hemodilution.2004
- Author(s)
  P.Cabrales, H.Sakai, A.G.Tsai, S.Takeoka, E.Tsuchida, M.Intaglietta
- Journal Title
  
  Am. J. Physiol. Heart Circ. Physiol. 288
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Metabolism of hemoglobin-vesicles(artificial oxygen carriers) and their influence on organ functions in a rat model.2004
- Author(s)
  Sakai H, Horinouchi H, Takeoka S, Takaori M, Kobayashi K, Tsuchida E
- Journal Title
  
  Biomaterials 25
  
  Pages: 4317-4325
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Physiologic capacity of RES for degradation of HbV after massive intravenous doses by daily repeated infusions for 14 days.2004
- Author(s)
  Sakai H, Masada Y, Horinouchi H, Ikeda E, Sou K, Takeoka S, et al.
- Journal Title
  
  J.Pharmacol.Exp.Ther. 311
  
  Pages: 874-884
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Metabolism of hemoglobin-vesicles (artificial oxygen carriers) and their influence on organ functions in a rat model.2004
- Author(s)
  H.Sakai, H.Horinouchi, Y.Masada, S.Takeoka, M.Takaori, K.Kobayashi, E.Tsuchida
- Journal Title
  
  Biomaterials 25
  
  Pages: 4317-4325
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Reduction of methemoglobin via electron transfer from photoreduced flavin : restoration of O_2-binding of concentrated hemoglobin solution coencapsulated in phospholipid vesicles.2004
- Author(s)
  H.Sakai, Y.Masada, H.Onuma, S.Takeoka, E.Tsuchida.
- Journal Title
  
  Bioconjugate Chem. 15
  
  Pages: 1037-1045
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Metabolism of hemoglobin-vesicles (artificial oxygen carriers) and their influence on organ functions in a rat model.2004
- Author(s)
  H.Sakai, H.Horinouchi, Y.Masada, S.Takeoka, M.Takaori.K.Kobayashi, E.Tsuchida.
- Journal Title
  
  Biomaterials 25
  
  Pages: 4317-4325
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Hemorrhagic shock resuscitation with an artificial oxygen carrier Hemoglobin Vesicle (HbV) maintains intestinal perfusion and suppresses the increase in plasma tumor necrosis factor alpha (TNF α).2004
- Author(s)
  A.Yoshizu, Y.Izumi, S.Park, H.Sakai, S.Takeoka, H.Horinouchi, E.Ikeda, E.Tsuchida, K.Kobayashi
- Journal Title
  
  ASAIO J. 50
  
  Pages: 458-463
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Physiologic capacity of reticuloendothelial system for degradation of hemoglobin-vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days.2004
- Author(s)
  H.Sakai, Y.Masada, H.Horinouchi, E.Ikeda, K Sou, S.Takeoka, M.Suematsu, M.Takaori, K.Kobayashi, E.Tsuchida
- Journal Title
  
  J. Pharmacol. Exp. Ther. 311
  
  Pages: 874-884
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Hemorrhagic shock resuscitation with an artificial oxygen carrier Hemoglobin Vesicle (HbV) maintains intestinal perfusion and suppresses the increase in plasma tumor necrosis factor alpha (TNFa).2004
- Author(s)
  A.Yoshizu, Y.Izumi, S.Park, H.Sakai, S.Takeoka, H.Horinouchi, E.Ikeda, E.Tsuchida, K.Kobayashi.
- Journal Title
  
  ASAIO J. 50
  
  Pages: 458-463
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Reduction of methemoglobin via electron transfer from photoreduced flavin : restoration of O_2-binding of concentrated hemoglobin solution coencapsulated in phospholipid vesicles.2004
- Author(s)
  H.Sakai, Y.Masada, H.Onuma, S.Takeoka, E.Tsuchida
- Journal Title
  
  Bioconjugate Chem. 15
  
  Pages: 1037-1045
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Reduction of MetHb via Electron Transfer from Photoreduced Flavin : Restoration of O2-Binding....2004
- Author(s)
  Sakai H, Masada Y, Onuma H, Takeoka S, Tsuchida E.
- Journal Title
  
  Bioconjugate Chem. 15
  
  Pages: 1037-1045
- Data Source
  KAKENHI-PROJECT-16300162
[Journal Article] Qunantification of cell-free layer width changes by erythrocyte aggregation in a 25-µm tube
- Author(s)
  B. Namgung, H. Sakai, S. Kim
- Volume
  (投稿中)
- Data Source
  KAKENHI-PROJECT-24650301
[Patent] ヘモグロビンのメト化抑制能を有する人工赤血球2017
- Inventor(s)
  酒井宏水、山田孫平
- Industrial Property Rights Holder
  奈良県立医科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Overseas
- Data Source
  KAKENHI-PROJECT-17H02087
[Patent] ヘモグロビンのメト化抑制能を有する人工赤血球2016
- Inventor(s)
  酒井宏水、山田孫平
- Industrial Property Rights Holder
  酒井宏水、山田孫平
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-040494
- Filing Date
  2016-03-02
- Data Source
  KAKENHI-PROJECT-25282136
[Patent] リポソームを含有する免疫抑制剤及びこれを用いた抑制性マクロファージの誘導方法2015
- Inventor(s)
  東　　寛、酒井宏水
- Industrial Property Rights Holder
  旭川医科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2015-04-01
- Data Source
  KAKENHI-PROJECT-25461578
[Patent] リポソームを含有する免疫抑制剤及びこれを用いた抑制性マクロファージの誘導方法2015
- Inventor(s)
  東　寛、酒井宏水
- Industrial Property Rights Holder
  国立大学法人旭川医科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-068296
- Filing Date
  2015-03-30
- Data Source
  KAKENHI-PROJECT-25461578
[Patent] METHOD FOR PRODUCTION OF VESICLES ENCAPSULATING FUNCTIONAL MATERIALS2013
- Inventor(s)
  酒井宏水
- Industrial Property Rights Holder
  早稲田大学
- Industrial Property Rights Type
  特許
- Filing Date
  2013-04-04
- Overseas
- Data Source
  KAKENHI-PROJECT-22300161
[Patent] 小胞体の製造法2012
- Inventor(s)
  酒井宏水
- Industrial Property Rights Holder
  早稲田大学
- Filing Date
  2012-04-04
- Overseas
- Data Source
  KAKENHI-PROJECT-22300161
[Patent] 小胞体の製造法2012
- Inventor(s)
  酒井宏水
- Industrial Property Rights Holder
  早稲田大学
- Filing Date
  2012-04-04
- Data Source
  KAKENHI-PROJECT-22300161
[Patent] 配位子置換型酸素輸液剤2006
- Inventor(s)
  酒井宏水, ほか
- Industrial Property Rights Holder
  (財)生産開発科学研究所
- Patent Publication Number
  2007-269665
- Filing Date
  2006-03-30
- Data Source
  KAKENHI-PROJECT-19300164
[Presentation] Translational Research of Artificial Red Cells for a Transfusion Alternative and O2/CO Therapeutics2019
- Author(s)
  Hiromi Sakai
- Organizer
  6th World Congress on Nanomedical Sciences (ISNSCON 2018)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02087
[Presentation] Present Status of Blood Substitute Research in Japan2018
- Author(s)
  Hiromi Sakai
- Organizer
  Symposium: “Transportador artificial de oxigeno” / Academia Nacional de Medicina de Mexico
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02087
[Presentation] Intraosseous Transfusion With Hemoglobin Vesicles for Severe Hemorrhagic Shock Rabbits2018
- Author(s)
  Hagisawa Kohsuke, Kinoshita Manabu, Sakai Hiromi
- Organizer
  American Heart Association 2018 Resuscitation Science Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11435
[Presentation] 人工赤血球製剤の生体適合性：非臨床試験による安全性の評価2018
- Author(s)
  酒井宏水
- Organizer
  第25回日本血液代替物学会年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-17H02087
[Presentation] ヘモグロビンとPEG 修飾ヘモグロビンのサブユニット交換平衡2018
- Author(s)
  松平崇・久禮智子・山本惠三・酒井宏水
- Organizer
  日本化学会第98春季年会 (2018)
- Data Source
  KAKENHI-PROJECT-17K01367
[Presentation] Ring-opening polymerization of loop-PEGylated hemoglobin2018
- Author(s)
  Takashi Matsuhira, Keizo Yamamoto, and Hiromi Sakai
- Organizer
  第67回高分子学会年次大会
- Data Source
  KAKENHI-PROJECT-17K01367
[Presentation] 人工赤血球(ヘモグロビンベシクル)製剤の新しい利用法2018
- Author(s)
  酒井宏水
- Organizer
  第66回日本輸血細胞治療学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17H02087
[Presentation] 命をつなぐ移植臓器灌流保存方法における人口赤血球（HbV）含有灌流保存液の研究2018
- Author(s)
  松野　直徒、庄中　達也、金澤　寛之、合地　美香子、大谷　将秀、高橋　裕之、西川　祐司、小原　弘道、暮地本　宙己、酒井　宏水、古川　博之、東　寛
- Organizer
  第25回日本血液代替物学会年次大会
- Data Source
  KAKENHI-PROJECT-17K10503
[Presentation] 化学修飾ヘモグロビンのαβサブユニット交換反応2018
- Author(s)
  松平崇、久禮智子、山本惠三、酒井宏水
- Organizer
  日本血液代替物学会第25回年次大会
- Data Source
  KAKENHI-PROJECT-17K01367
[Presentation] 人工赤血球(ヘモグロビンベシクル)の医療応用2018
- Author(s)
  酒井宏水
- Organizer
  MBTオープンミーティング2018 in 東京
- Invited
- Data Source
  KAKENHI-PROJECT-17H02087
[Presentation] Ring-opening Polymerization of Hemoglobin Using its Reversible Association-Dissociation Equilibrium of α2β2 Subunits2018
- Author(s)
  Takashi Matsuhira, Keizo Yamamoto, and Hiromi Sakai
- Organizer
  The International Symposium for Materials Scientists "Inspiration for Innovation by Interaction" (ISMS-III)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01367
[Presentation] 備蓄・緊急投与が可能な人工赤血球製剤の実用化を目指す研究2018
- Author(s)
  酒井宏水
- Organizer
  日本赤十字社第30回学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-17H02087
[Presentation] ヘモグロビンとNAD(P)Hとの共存により生じる抗酸化作用の機序2018
- Author(s)
  山田孫平、松平崇、山本恵三、酒井宏水
- Organizer
  日本化学会第98春季年会
- Data Source
  KAKENHI-PROJECT-17H02087
[Presentation] Physicochemical characterization of poly-(PEG-hemoglobin) produced by ring-opening polymerization2018
- Author(s)
  Takashi Matsuhira, Keizo Yamamoto, and Hiromi Sakai
- Organizer
  第67回高分子討論会
- Data Source
  KAKENHI-PROJECT-17K01367
[Presentation] Translational Research of Artificial Red Cells (Hemoglobin-Vesicles) for Oxygen and Carbon Monoxide Therapeutics2017
- Author(s)
  Hiromi Sakai
- Organizer
  The 17th IUPAC International Symposium on MacroMolecular Complexes
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02087
[Presentation] Hidden antioxidative functions of NADH coexisting with hemoglobin2017
- Author(s)
  Hiromi Sakai, Magohei Yamada
- Organizer
  The 254th ACS National Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02087
[Presentation] Translational Research of Hb-vesicles (Artificial Red Cells) for a Transfusion Alternative and O2/CO Therapeutics2017
- Author(s)
  Hiromi Sakai
- Organizer
  XVI-International Symposium on Blood Substitutes and Oxygen Therapeutics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02087
[Presentation] 分子間架橋したヘモグロビン集合体の作製と人工酸素運搬体としての性質2017
- Author(s)
  松平崇、山本惠三、酒井宏水
- Organizer
  日本バイオマテリアル学会関西ブロック第12回若手研究発表会
- Data Source
  KAKENHI-PROJECT-17K01367
[Presentation] 備蓄・緊急投与が可能な人工赤血球製剤の実用化を目指す研究2017
- Author(s)
  酒井宏水、小田切優樹、東寛、木下学、高瀬凡平、河野光智、岩本美智子、堀之内宏久、高折益彦、小林紘一
- Organizer
  第25回日本血液代替物学会年次大会
- Data Source
  KAKENHI-PROJECT-17H02087
[Presentation] 備蓄・緊急投与が可能な人工赤血球製剤の開発2017
- Author(s)
  酒井宏水
- Organizer
  第1回日本集中治療医学会関東甲信越支部学術集会
- Data Source
  KAKENHI-PROJECT-17H02087
[Presentation] Reactivity of Cys beta93 of native and beta-crosslinked Hbs2017
- Author(s)
  Takashi Matsuhira, Keizo Yamamoto, Hiromi Sakai
- Organizer
  60th Anniversary of Artificial Cell in conjunction with XVI ISBS International Symposium Blood Substitutes & Oxygen Therapeutics V ISNS Nanomedicine Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01367
[Presentation] 備蓄・緊急投与が可能な人工赤血球製剤2017
- Author(s)
  酒井宏水
- Organizer
  第25回小児ITP研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17H02087
[Presentation] Combination Therapy with Red Blood Cell Substitute and Platelet Substitute Effectively Rescues Rabbits from Massive Hemorrhage Caused by Thrombocytopenic Coagulopathy.2017
- Author(s)
  Kinoshita Manabu, Hagisawa Kohsuke, Sakai Hiromi, Takeoka Shinji, Saitoh Daizoh, Shinomiya Nariyoshi, Seki Shuhji
- Organizer
  Military Health System Research Symposium 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11435
[Presentation] Prolonged in vivo functional lifespan of an artificial oxygen carrier (hemoglobin vesicles) using a transmembrane electron mediator and electron energies of red blood cells glycolysis2015
- Author(s)
  Hiromi Sakai
- Organizer
  ICMAT2015 & IUMRS-ICA2015
- Place of Presentation
  Suntec, Singapore
- Year and Date
  2015-06-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25282136
[Presentation] Hb-vesicles (赤血球代替物)の有用性と開発の状況2015
- Author(s)
  酒井宏水
- Organizer
  第39回日本血液事業学会総会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2015-10-05
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25282136
[Presentation] Translational research of hemoglobin-vesicles as a transfusion alternative2015
- Author(s)
  Hiromi Sakai
- Organizer
  International Society on Blood Substitutes (ISBS)
- Place of Presentation
  Lund University, Sweden
- Year and Date
  2015-06-21
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25282136
[Presentation] ラット肺切除周術期出血モデルにおけるヘモグロビン小胞体投与の循環動態と血液酸素化に及ぼす影響2015
- Author(s)
  河野光智、松田信作、神山育男、堀之内宏久、渡辺真純、酒井宏水、小林紘一、岩崎正之
- Organizer
  第22回日本血液代替物学会年次大会
- Place of Presentation
  熊本大学薬学部（大江キャンパス）宮本記念館コンベンションホール（熊本県熊本市）
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-25462183
[Presentation] 人工赤血球（ヘモグロビン小胞体）を構成する脂質２重膜の薬理作用について2015
- Author(s)
  東　　寛、吉田陽一郎、高橋弘典、高橋大輔、藤原満博、酒井宏水
- Organizer
  日本血液代替物学会
- Place of Presentation
  熊本
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-25461578
[Presentation] 備蓄・緊急投与が可能な人工赤血球製剤の実用化を目指す研究 / シンポジウム1「人工赤血球製剤の臨床への橋渡し研究」2015
- Author(s)
  酒井宏水、小田切優樹、東寛、木下学、高瀬凡平、河野光智、岩本美智子、堀之内宏久、高折益彦、小林紘一
- Organizer
  第22回日本血液代替物学会年次大会
- Place of Presentation
  熊本大学薬学部（大江キャンパス）宮本記念館コンベンションホール（熊本県熊本市）
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-25462183
[Presentation] Transmembrane electron mediators to extract electron energies of RBC glycolysis for prolonged in vivo functional lifespan of an artificial oxygen carrier (Hb-vesilces)2015
- Author(s)
  Hiromi Sakai
- Organizer
  The 10th World Congress for Microcirculation
- Place of Presentation
  Kyoto International Conference Center
- Year and Date
  2015-09-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25282136
[Presentation] 人工酸素運搬体による重症マラリア合併症の補助療法の開発2014
- Author(s)
  矢野和彦、岩上盛敏、酒井宏水、狩野繁之
- Organizer
  第83回日本寄生虫学会大会
- Place of Presentation
  愛媛大学
- Data Source
  KAKENHI-PROJECT-24659193
[Presentation] Development of an adjuvant therapy for severe malaria with the hemoglobin vesicle,an artificial oxygen carrier2014
- Author(s)
  Yano Kazuhiko,Iwagami Moritoshi,Sakai Hiromi,Kano Shigeyuki
- Organizer
  13^<th> International Congress of Parasitology
- Place of Presentation
  Hotel Camino Real Mexico City
- Data Source
  KAKENHI-PROJECT-24659193
[Presentation] 人工赤血球(Hb小胞体)の新しい利用法の深求と、シンガポールにおける融合研究拠点の形成2013
- Author(s)
  酒井宏水
- Organizer
  第6回生物学・化学・情報科学融合のための戦略的先進理工学研究基盤の形成支援事業シンポジウム
- Place of Presentation
  早稲田大学西早稲田キャンパス
- Year and Date
  2013-12-14
- Data Source
  KAKENHI-PROJECT-24650301
[Presentation] 人工赤血球(ヘモグロビン小胞体）を構成する脂質２重膜のもつ免疫調節効果について2013
- Author(s)
  東　　寛, 　酒井宏水
- Organizer
  第20回日本血液代替物学会年次大会
- Place of Presentation
  奈良県新公会堂
- Data Source
  KAKENHI-PROJECT-25461578
[Presentation] 肺切除周術期出血モデルにおけるヘモグロビン小胞体投与とHIF-1alphaの発現について2013
- Author(s)
  河野光智、重信敬夫、神山育男、渡辺真純、堀之内宏久、酒井宏水、小林紘一
- Organizer
  第20回日本血液代替物学会年次大会
- Place of Presentation
  奈良県新公会堂
- Data Source
  KAKENHI-PROJECT-25462183
[Presentation] リポソームの投与後の脾細胞からCon A刺激により産生されるサイトカイン・ケモカイン動態の網羅的解析2013
- Author(s)
  東　　寛, 高橋弘典, 永井一樹, 長森恒久, 高橋大輔, 藤原満博, 酒井宏水
- Organizer
  第20回日本血液代替物学会年次大会
- Place of Presentation
  奈良県新公会堂
- Data Source
  KAKENHI-PROJECT-25461578
[Presentation] 人工赤血球(ヘモグロビン小胞体)をブタに少量投与したときの血行動態に関する検討2012
- Author(s)
  酒井宏水、鈴木勇司、宗慶太郎、狩野真由美
- Organizer
  第19回日本血液代替物学会年次大会
- Place of Presentation
  旭川大雪クリスタルホール
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] 人工赤血球/代用血漿剤(水溶性高分子)分散系のレオロジー挙動2012
- Author(s)
  酒井宏水
- Organizer
  第60回レオロジー討論会
- Place of Presentation
  名古屋大学
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Artificial Red Cells (Hemoglobin-vesicles) as a Cellular-type Hemoglobin-based Oxygen Carrier for Versatile Clinical Applications2012
- Author(s)
  Hiromi Sakai
- Organizer
  BIT’s 1st Annual International Symposium of Hematology
- Place of Presentation
  Beijing, China
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Cardiopulmonary hemodynamic responses to the injection of hemoglobin-vesicles (artificial oxygen carriers) in miniature pigs2012
- Author(s)
  Hiromi Sakai
- Organizer
  9th World Biomaterials Congress
- Place of Presentation
  Chengdu, China
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Gas Bioengineering of Artificial Red Cells (invited)2012
- Author(s)
  H. Sakai
- Organizer
  28th Annual Conference, on 40th Anniversary of Faculty of Medicine, Prince of Songkla University
- Place of Presentation
  Hat Yai, Thailand
- Year and Date
  2012-08-08
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] 人工赤血球(ヘモグロビン小胞体)の物理化学的特徴と体内酸素輸送機能2012
- Author(s)
  酒井宏水
- Organizer
  第13回医療化学懇談会
- Place of Presentation
  国立国際医療研究センター(東京都)(招待講演)
- Year and Date
  2012-01-21
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Cardiopulmonary hemodynamic responses to the injection of hemoglobin-vesicles (artificial oxygen carriers) in miniature pigs2012
- Author(s)
  H. Sakai, Y. Suzuki, K. Sou, M. Kano
- Organizer
  9th World Biomaterials Congress
- Place of Presentation
  Chengdu
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Artificial Red Cells (Hemoglobin-vesicles) as a Cellular-type Hemoglobin-based Oxygen Carrier for Versatile Clinical Applications2012
- Author(s)
  H. Sakai
- Organizer
  BIT's 1st Annual International Symposium of Hematology
- Place of Presentation
  Beijing
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] 人工赤血球/代用血漿剤(水溶性高分子)分散系のレオロジー挙動2012
- Author(s)
  酒井宏水
- Organizer
  第60回レオロジー討論会
- Place of Presentation
  名古屋大学
- Data Source
  KAKENHI-PROJECT-24650301
[Presentation] リポソーム製剤としての人工赤血球の効率の高い製造法2012
- Author(s)
  酒井宏水
- Organizer
  産学官連携推進会議<第11回>イノベーションジャパン2012
- Place of Presentation
  東京フォーラム
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Recent topics of Artificial Red Cells Project2012
- Author(s)
  H. Sakai
- Organizer
  The 3rd Annual Symposium of Waseda Bioscience Research Institute in Singapore
- Place of Presentation
  Biopolis, Singapore
- Year and Date
  2012-11-02
- Data Source
  KAKENHI-PROJECT-24650301
[Presentation] Gas Bioengineering of Artificial Red Cells2012
- Author(s)
  Hiromi Sakai
- Organizer
  28th Annual Conference, on 40th Anniversary of Faculty of Medicine, Prince of Songkla University
- Place of Presentation
  Hat Yai, Thailand
- Invited
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Artificial oxygen carriers (Hbvesicles) as a transfusion alternative and for oxygen therapeutics2011
- Author(s)
  H. Sakai
- Organizer
  The 5th Kuala Lumpur International Conference on Biomedical Engineering
- Place of Presentation
  Kuala Lumpur, Malaysia
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Hemoglobin nanoencapsulation favorably retards gas reactions2011
- Author(s)
  H. Sakai
- Organizer
  2nd anniversary symposium of Waseda Bioscience Research Institute in Singapore
- Place of Presentation
  Matrix, Biopolis, Singapore
- Year and Date
  2011-09-29
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Hb encapsulation in vesicles retards gas reactions by intracellular diffusion barrier and decreased diffusion of vesicles2011
- Author(s)
  Hiromi Sakai
- Organizer
  第49回日本生物物理学会年会
- Place of Presentation
  兵庫県立大学書写キャンパス(兵庫県)
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Characteristics of hemoglobin vesicles as a cellular type artificial oxygen carrier2011
- Author(s)
  Hiromi Sakai
- Organizer
  XIII International Symposium on Blood Substitutes and Oxygen Therapeutics
- Place of Presentation
  ボストン(米国)(招待講演)
- Year and Date
  2011-07-28
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Artificial Red Cells (Hemoglobin-Vesicles) for a Transfusion Alternative and Oxygen Therapeutics2011
- Author(s)
  Hiromi Sakai
- Organizer
  International Conference on Materials for Advanced Technologies
- Place of Presentation
  シンガポール
- Year and Date
  2011-06-27
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Hb encapsulation in vesicles retards gas reactions by intracellular diffusion barrier and decreased diffusion of vesicles2011
- Author(s)
  H. Sakai
- Organizer
  第49回日本生物物理学会年会
- Place of Presentation
  兵庫県立大書写キャンパス
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] 人工赤血球:ヘモグロビン小胞体の新しい臨床応用2011
- Author(s)
  酒井宏水
- Organizer
  Technology Link in WTLO
- Place of Presentation
  早稲田大学(招待講演)
- Year and Date
  2011-01-14
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Hemoglobin nanoencapsulation favorably retards gas reactions2011
- Author(s)
  Hiromi Sakai
- Organizer
  2nd anniversary symposium of Waseda Bioscience Research Institute in Singapore
- Place of Presentation
  シンガポール(招待講演)
- Year and Date
  2011-09-29
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] 日本の人工酸素運搬体の歴史と現状2011
- Author(s)
  酒井宏水
- Organizer
  第18回日本血液代替物学会
- Place of Presentation
  北海道大学医学部学友会館フラテ
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] シンガポールにおける人工赤血球の研究(WABIOS ランチョンセミナー)2011
- Author(s)
  H. Sakai
- Organizer
  第49回日本生物物理学会年会
- Place of Presentation
  兵庫県立大書写キャンパス
- Year and Date
  2011-09-18
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] 人工赤血球 : ヘモグロビン小胞体の新しい臨床応用2011
- Author(s)
  酒井宏水
- Organizer
  Technology Link in WTLO 早稲田大学産官学研究推進センター
- Place of Presentation
  早稲田大学55 号館N 棟大会議室
- Year and Date
  2011-01-14
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Developing next generation artificial oxygen carrier (artificial red cells) for versatile clinical application2011
- Author(s)
  H.Sakai
- Organizer
  Drug Discovery World Asia 2011
- Place of Presentation
  Marina Bay Sands, Singapore(招待講演)
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Characteristics of hemoglobin vesicles as a cellular type artificial oxygen carrier2011
- Author(s)
  H. Sakai, H. Horinouchi, K. Kobayashi
- Organizer
  XIII International Symposium on Blood Substitutes and Oxygen Therapeutics
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Artificial oxygen carriers (hemoglobin-vesicles) as a transfusion alternative and for oxygen therapeutics2011
- Author(s)
  Hiromi Sakai
- Organizer
  The 5th Kuala Lumpur International Conference on Biomodical Engineering
- Place of Presentation
  クアラルンプール(マレーシア)
- Year and Date
  2011-06-23
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] 日本の人工酸素運搬体の歴史と現状2011
- Author(s)
  酒井宏水
- Organizer
  第18回日本血液代替物学会
- Place of Presentation
  北海道大学医学部学友会館フラテ(北海道)(招待講演)
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Developing next generation artificial oxygen carrier (artificial red cells) for versatile clinical application2011
- Author(s)
  H. Sakai
- Organizer
  Drug Discovery World Asia 2011
- Place of Presentation
  Singapore
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Hb encapsulation in vesicles retards NO- and CO-binding and O2-release2011
- Author(s)
  Hiromi Sakai
- Organizer
  International Society on Oxygen Transport to Tissue 2011
- Place of Presentation
  ワシントンDC(米国)
- Year and Date
  2011-07-24
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Hb encapsulation in vesicles retards NO- and CO-binding and O_2-release2011
- Author(s)
  H. Sakai
- Organizer
  International Society on Oxygen Transport to Tissue 2011
- Place of Presentation
  Georgetown Univ., Washington DC, USA
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Artificial Red Cells (Hb-Vesicles) for a Transfusion Alternative and Oxygen Therapeutics2011
- Author(s)
  H. Sakai
- Organizer
  International Conference on Materials for Advanced Technologies.
- Place of Presentation
  Suntec, Singapore
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Nano dimension hemoglobin lipid vesicles as oxygen carriers for versatile clinical applications2010
- Author(s)
  H.Sakai
- Organizer
  The 2nd World Congress of the International Academy of Nanomedicine
- Place of Presentation
  Antalya, Turkey(招待講演)
- Year and Date
  2010-10-03
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] 人工赤血球:ヘモグロビン小胞体の新しい臨床応用2010
- Author(s)
  酒井宏水
- Organizer
  第9回国際バイオEXPO
- Place of Presentation
  東京ビックサイト(招待講演)
- Year and Date
  2010-06-30
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] ヘモグロビン小胞体の開発の歴史と現状2010
- Author(s)
  酒井宏水
- Organizer
  第17回日本血液代替物学会年次大会
- Place of Presentation
  熊本市国際交流会館(招待講演)
- Year and Date
  2010-10-17
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Characteristics of Hb-vesicles as a cellular type Hb-based oxygen carrier2010
- Author(s)
  H.Sakai
- Organizer
  The 2nd International Conference on Cellular & Molecular Bioen gineering
- Place of Presentation
  Nanyang Technol.Univ.
- Year and Date
  2010-08-02
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Hemoglobin-vesicles as artificial oxygen carriers based on bioconjugate chemistry and nanobiotechnology for versatile clinical application2010
- Author(s)
  H.Sakai
- Organizer
  BIT's 1st Annual World Conference of NanoMedicine-2010
- Place of Presentation
  Beijing, China
- Year and Date
  2010-10-23
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] HEMOGLOBIN-VESICLES, ARTIFICIAL RED CELLS, AS O_2 AND CO CARRIERS FOR CYTOPROTECTION2010
- Author(s)
  H. Sakai, H. Horinoichi, K. Kobayashi, E. Tsuchida
- Organizer
  The 5th SBE International Conference on Bioengineering and Nanotechnology
- Place of Presentation
  Biopolis, Singapore
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] HB-VESICLES AS AN ARTIFICIAL O2 CARRIER : THE REACTION PROFILES WITH GAS MOLECULES (O2, NO, AND CO)2010
- Author(s)
  H.Sakai
- Organizer
  The 5th SBE International Conference on Bioengineering and Nanotechnology
- Place of Presentation
  Biopolis, Singapore
- Year and Date
  2010-08-06
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Nano dimension hemoglobin lipid vesicles as oxygen carriers for versatile clinical applications2010
- Author(s)
  H. Sakai, H. Horinouchi, E. Tsuchida, K. Kobayahi
- Organizer
  The 2nd World Congress of the International Academy of Nanomedicine
- Place of Presentation
  Calista Luxury Resort, Antalya, Turkey
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] 人工赤血球 : ヘモグロビン小胞体の新しい臨床応用2010
- Author(s)
  酒井宏水
- Organizer
  第9回国際バイオEXPO
- Place of Presentation
  東京ビックサイト
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] 人工赤血球(ヘモグロビン小胞体)の開発状況(Invited)2010
- Author(s)
  酒井宏水
- Organizer
  信州大学繊維学部G-COE 国際特別講演会
- Year and Date
  2010-11-22
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] ヘモグロビン小胞体の開発の歴史と現状2010
- Author(s)
  酒井宏水
- Organizer
  第17回日本血液代替物学会年次大会
- Place of Presentation
  熊本市国際交流会館
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Physicochemical importance of the red blood cells structure in the designing of artificial red cells (Invited)2010
- Author(s)
  H. Sakai
- Organizer
  Seminar at Department of Bioengineering
- Place of Presentation
  University of California, San Diego
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Hemoglobin-vesicles as artificial oxygen carriers based on bioconjugate chemistry and nanobiotechnology for versatile clinical application2010
- Author(s)
  H. Sakai
- Organizer
  BIT's 1st Annual World Conference of NanoMedicine-2010
- Place of Presentation
  International Convention Center / Beijing, China
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Hemoglobin-vesicles as oxygen carriers for versatile clinical application2010
- Author(s)
  H. Sakai
- Organizer
  Applied Chemistry Lecture Series of Changchun Institute of Applied Chemistry, Chinese Academy of Sciences (CIAC)
- Place of Presentation
  Changchun, China
- Year and Date
  2010-10-21
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] Characteristics of Artificial Red Cells (hemoglobin-vesicles) as a transfusion alternative and for oxygen therapeutics (Invited)2010
- Author(s)
  H. Sakai
- Organizer
  Department of Biochemistry Seminars
- Place of Presentation
  Biochemistry, School of Medicine, National Univ. of Singapore
- Year and Date
  2010-11-29
- Data Source
  KAKENHI-PROJECT-22300161
[Presentation] 人工赤血球―水溶性高分子(代用血漿剤)分散系のレオロジ―特性2009
- Author(s)
  酒井宏水
- Organizer
  第48回日本生体医工学会大会
- Place of Presentation
  東京タワーホール船堀
- Data Source
  KAKENHI-PROJECT-19300164
[Presentation] 細胞型人工酸素運搬体をつくる -ヘモグロビン精製から小胞体化まで-2009
- Author(s)
  酒井宏水
- Organizer
  第16回日本血液代替物学会年次大会
- Place of Presentation
  慶應義塾大学北里講堂
- Data Source
  KAKENHI-PROJECT-19300164
[Presentation] Physicochemical characteristics of Hb-Vesicles as RBC substitutes2009
- Author(s)
  酒井宏水
- Organizer
  XII International Symposium on Blood Substitutes
- Place of Presentation
  Parma, Italy
- Data Source
  KAKENHI-PROJECT-19300164
[Presentation] Physicochemical characteristics of Hb-Vesicles as RBC substitutes2009
- Author(s)
  H. Sakai, K. Sou, H. Horinouchi, K. Kobayashi, E. Tsuchida.
- Organizer
  XII International Symposium on Blood Substitutes
- Place of Presentation
  Parma
- Data Source
  KAKENHI-PROJECT-19300164
[Presentation] 脳内出血モデルによるHb小胞体の脳神経組織への影響に関する検討2009
- Author(s)
  酒井宏水
- Organizer
  第16回日本血液代替物学会年次大会
- Place of Presentation
  慶應義塾大学北里講堂
- Data Source
  KAKENHI-PROJECT-19300164
[Presentation] 人工赤血球(ヘモグロビン小胞体)のガスバイオロジー2009
- Author(s)
  酒井宏水
- Organizer
  第48回日本生体医工学会大会
- Place of Presentation
  東京タワーホール船堀
- Data Source
  KAKENHI-PROJECT-19300164
[Presentation] Hb-vesicle, a cellular Hb-based oxygen carrier, fulfills the physiological roles of the RBC structure.2008
- Author(s)
  H. Sakai
- Organizer
  The 6th Current Issues on Blood Substitute Research
- Place of Presentation
  Keio University
- Data Source
  KAKENHI-PROJECT-19300164
[Presentation] Hb-Vesicle : A Cellular Hb-Based Oxygen Carrier that Fulfills the Physiological Roles of the RBC structure2008
- Author(s)
  H. Sakai
- Organizer
  ISOTT 2008 (Intenational Society on Oxygen Transport to Tissue)
- Place of Presentation
  Sapporo Prince Hotel
- Data Source
  KAKENHI-PROJECT-19300164
[Presentation] 人工赤血球(ヘモグロビン小胞体)とCOの反応性と細胞保護効果2008
- Author(s)
  酒井宏水
- Organizer
  第46回日本人工臓器学会大会
- Place of Presentation
  六本木ヒルズ
- Data Source
  KAKENHI-PROJECT-19300164
[Presentation] Hb-Vesicle: A Cellular Hb-Based Oxygen Carrier that Fulfills the Physiological Roles of the RBC Structure2008
- Author(s)
  H. Sakai, K. Sou, H. Horinouchi, K. Kobayashi, E. Tsuchida
- Organizer
  ISOTT 2008 (Intenational Society on Oxygen Transport to Tissue)
- Place of Presentation
  Sapporo Prince Hotel
- Data Source
  KAKENHI-PROJECT-19300164
[Presentation] Hemoglobin-vesicles as 02- and CO carriers2008
- Author(s)
  H. Sakai
- Organizer
  The 6th Current Issues on Blood Substitute Research
- Place of Presentation
  Keio University
- Data Source
  KAKENHI-PROJECT-19300164
[Presentation] diffusion barrier,and the relevance to the vasoinactive properties of RBCs and Hb-vesicles2008
- Author(s)
  H. Sakai, A. Sato, S. Takeoka, E. Tsuchida
- Organizer
  第33回日本微小循環学会総会
- Place of Presentation
  慶應義塾大学
- Data Source
  KAKENHI-PROJECT-19300164
[Presentation] Hemoglobin-vesicles as O2- and CO carriers2008
- Author(s)
  H. Sakai, H. Horinouchi, K. Kobayashi, E. Tsuchida
- Organizer
  The 6th Current Issues on Blood Substitute Research
- Place of Presentation
  Keio University Shinanomachi Campus
- Data Source
  KAKENHI-PROJECT-19300164
[Presentation] (招待講演)医用生体工学と救命医療の接点、人工赤血球への期待2008
- Author(s)
  酒井宏水
- Organizer
  第23回日本救命医療学会総会・学術集会イブニングセミナー
- Place of Presentation
  センターホール(東京)
- Year and Date
  2008-09-05
- Data Source
  KAKENHI-PROJECT-19300164
[Presentation] ヘモグロビン小胞体(人工赤血球)のNO, CO反応挙動と血管不活性との相関2008
- Author(s)
  酒井宏水
- Organizer
  第57回高分子学会年次大会
- Place of Presentation
  パシフイコ横浜
- Data Source
  KAKENHI-PROJECT-19300164
[Presentation]2007
- Author(s)
  酒井宏水、土田英俊
- Organizer
  第4回Heme Oxygenase研究フォーラム
- Place of Presentation
  京都府立医科大学
- Year and Date
  2007-08-24
- Data Source
  KAKENHI-PROJECT-19300164
[Presentation] Hb-vesicles as artificial oxygen carriers: Interactions with ligand molecules in the production process and in blood circulation.2007
- Author(s)
  H. Sakai, H. Horinouchi, K. Kobayashi, E. Tsuchida.
- Organizer
  2007 Joint Congress of the 45th Annual Meeting of the Japanese Society for Artificial Organs (JSAO) and The 2nd Meeting of the International Federation for Artificial Organs (IFAO)
- Place of Presentation
  Osaka
- Data Source
  KAKENHI-PROJECT-19300164
[Presentation] Fluid resuscitation with Hemoglobin-vesicles(Artificial Red Cells) in hemorrhaged rats and profiles of recovery for 14 days.2007
- Author(s)
  H. Sakai, H. Horinouchi, E. Tsuchida, K. Kobayashi.
- Organizer
  53rd Annual Conference of ASAIO
- Place of Presentation
  Chicago,USA
- Data Source
  KAKENHI-PROJECT-19300164
[Presentation] Hemoglobin vesicles as artificial oxygen carriers: Interactions with ligand molecules in the production process and in blood circulation.2007
- Author(s)
  H. Sakai, A. Sato, K. Sou, H. Horinouchi, K. Kobayashi, E. Tsuchida.
- Organizer
  The 11th International Symposium on Blood Substitutes
- Place of Presentation
  Beijing,China
- Data Source
  KAKENHI-PROJECT-19300164
[Presentation] ヘモグロビン小胞体と各種代用血漿剤の併用に関する検討2007
- Author(s)
  酒井宏水、佐藤敦、武岡真司、堀之内宏久、高折益彦、小林紘一、土田英俊
- Organizer
  第14回日本血液代替物学会年次大会
- Place of Presentation
  慶應義塾大学
- Data Source
  KAKENHI-PROJECT-19300164
[Presentation] Hemoglobin vesicles as artificial oxygen carriers: Interactions with ligand molecules in the production process and in blood circulation.2007
- Author(s)
  H. Sakai, A. Sato, K. Sou, H. Horinouchi, K. Kobayashi, E. Tsuchida.
- Organizer
  The 11th International Symposium on Blood Substitutes
- Place of Presentation
  Beijing, China
- Data Source
  KAKENHI-PROJECT-19300164
[Presentation] Hb-vesicles as artificial oxygen carriers:Intenactions with ligand molecules in the production process and in blood circulation.2007
- Author(s)
  H. Sakai, H. Horinouchi, K. Kobayashi, E. Tsuchida.
- Organizer
  2007 Joint Congress of the 45th Annual Meeting of JSAO and The 2nd Meeting of IFAO
- Place of Presentation
  Osaka
- Data Source
  KAKENHI-PROJECT-19300164
[Presentation] Hemoglobin-vesicles for transfusion alternative and oxygen therapeutics
- Author(s)
  H. Sakai
- Organizer
  International Society on Oxygen Transport to Tissue (ISOTT) 2014
- Place of Presentation
  University College London, UK
- Year and Date
  2014-06-28 – 2014-07-03
- Invited
- Data Source
  KAKENHI-PROJECT-25282136
[Presentation] 赤血球解糖系が産生する電子エネルギーの活用による人工赤血球(ヘモグロビンベシクル)の機能持続効果
- Author(s)
  酒井宏水、Karin Kettisen、伊賀弓佳
- Organizer
  日本化学会第95春季年会
- Place of Presentation
  日本大学船橋キャンパス
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-25282136
[Presentation] 人工赤血球の新しい利用法の深求とシンガポールにおける融合研究拠点の形成
- Author(s)
  酒井宏水
- Organizer
  第６回生物学・化学・情報科学融合のための戦略的先進理工学研究基盤の形成支援事業シンポジウム
- Place of Presentation
  早稲田大学
- Invited
- Data Source
  KAKENHI-PROJECT-24650301
[Presentation] 体内電子供与系の活用による人工赤血球(ヘモグロビン小胞体)の機能復元
- Author(s)
  酒井宏水、Li Bing、Lim Wei Lee
- Organizer
  日本化学会第94春季年会
- Place of Presentation
  名古屋大学東山キャンパス
- Data Source
  KAKENHI-PROJECT-25282136
[Presentation] 輸血治療を補完する人工赤血球の効力と安全性
- Author(s)
  東　寛、藤原満博、酒井宏水
- Organizer
  第62回日本輸血細胞治療学会
- Place of Presentation
  奈良
- Year and Date
  2014-05-15 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-25461578

1. KOBAYASHI Koichi (80051704)

# of Collaborated Projects: 4 results

# of Collaborated Products: 68 results
2. AZUMA Hiroshi (00167909)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
3. KOHNO Mitsutomo (10276272)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. OHTA Hidenobu (80422103)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TSUCHIDA Eishun (90063461)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. TAKEOKA Shinji (20222094)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 長森恒久 (40400098)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. 高橋弘典 (50431408)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
9. 岡嶋一樹 (70213931)

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# of Collaborated Products: 0 results
10. 更科岳大 (40431407)

# of Collaborated Projects: 2 results

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11. 吉田陽一郎 (80750306)

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12. 松平崇 (20570998)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
13. HORINOUCHI Hirohisa (60173647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NOMORI Hiroaki (90146613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. IZUMI Yotaro (90245506)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. LI Heng (70621994)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. INAGAKI Masumi (70203198)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KANO Shigeyuki (60233912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. YANO Kazuhiko (30392393)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
20. IWAGAMI Moritoshi (20392392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. SUEMATSU Makoto (00206385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. SAKAI Kiyotaka (00063727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. NISHIDA Hiroyuki (90120930)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. UMEZU Mitsuo (90132927)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. WATANABE Masazumi (90201227)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
26. MIYAZAKI Takuro (00584749)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
27. Hagisawa Kohsuke (50539244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
28. 古谷野伸 (30312458)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 内藤祐介 (00623498)

# of Collaborated Projects: 1 results

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30. 井上聡己 (50295789)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
31. 川口昌彦 (60275328)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
32. 羽藤泰 (10365281)

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33. 大塚崇 (40306717)

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34. 重信敬夫 (50626702)

# of Collaborated Projects: 1 results

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35. 土谷智史 (30437884)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
36. 永安武 (80284686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
37. 畑地豪 (80437889)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 鈴木英紀 (30158977)

# of Collaborated Projects: 1 results

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39. 木下学 (70531391)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
40. 磯山隆 (20302789)

# of Collaborated Projects: 1 results

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# of Collaborated Projects: 1 results

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# of Collaborated Projects: 1 results

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43. 山本惠三 (90254490)

# of Collaborated Projects: 1 results

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44. 山田孫平 (90839317)

# of Collaborated Projects: 1 results

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45. 鳥海尚久 (30516399)

# of Collaborated Projects: 1 results

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46. TAKAGI Katsunori

# of Collaborated Projects: 1 results

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47. YAMASAKI Keishi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
48. SEKI Shuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. SAITOH Daizoh

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
50. 田口和明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakai Hiromi 酒井 宏水

SAKAI Hiromi 酒井 宏水

酒井 宏永 サカイ ヒロミ

Research Projects

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Search into the mechanism of B7-H3 expressing MDSC generation by liposome and its T cell suppressionOngoing

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人工血液カクテルによる次世代保育器の開発Ongoing

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Synthesis and in vivo characterization of polymer-multilinked hemoglobin assembly as artificial oxygen carrierOngoing

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Application of artificial oxygen-carrying hemoglobin vesicles for marginal liver grafts in machine perfusion preservationOngoing

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Artificial red cells with a defense function to oxidative stressPrincipal InvestigatorOngoing

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リポソーム誘導MDSCに発現するB7-H3分子誘導機序とその免疫抑制効果への関与Ongoing

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呼吸停止時の人工赤血球の有用性の検討Ongoing

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Prolonged functional lifespan of artificial red cells by using the electron energies produced by erythrocyte glycolysisPrincipal Investigator

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Microhemodynamic properties and gas reactions of abnormal RBCs in narrow tubesPrincipal Investigator

Sakai Hiromi 酒井宏水

SAKAI Hiromi 酒井宏水

酒井宏永サカイヒロミ