kinoshita manabu 木下学

… Alternative Names

Researcher Number	70531391
Other IDs
Affiliation (Current)	2020: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 免疫・微生物学, 准教授
Affiliation (based on the past Project Information) *help	2017 – 2020: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 免疫・微生物学, 准教授 2017: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 医学教育部医学科専門課程, 准教授 2016: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 免疫・微生物学, 准教授 2016: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, その他部局等, 准教授 2011 – 2016: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 准教授 … More
Review Section/Research Field	Principal Investigator Emergency medicine / Radiation science / Basic Section 55060:Emergency medicine-related Except Principal Investigator Emergency medicine / General surgery / Basic Section 49030:Experimental pathology-related / Experimental pathology / Digestive surgery / Bacteriology (including Mycology) / Integrated Nutrition Science … More
Keywords	Principal Investigator クッパー細胞 / 活性酸素 / compromised hosts / 熱傷 / 複合免疫不全 / 好中球 / 熱傷後感染 / IL-18 / CD68陽性クッパー細胞 / CD11b陽性クッパー細胞 … More Except Principal Investigator 光線力学療法 / マクロファージ / Kupffer細胞 / 敗血症 / ナノシート / 免疫学 / 自然免疫 / 腫瘍免疫 / NK細胞 / sepsis / IFN-γ / Helicobacter pylori / 胃癌 / 腹膜播種 / Kupffer cells / 血小板代替物 / 創傷治癒 / 感染症 / 細菌 / 好中球 / 貪食活性 / 殺菌作用 / 脂肪由来幹細胞 / 幹細胞 / 再生医療 / NKT細胞 / LXR / 凝固障害 / 血液代替物 / 肝臓 / LPSトレランス / 肝臓外科学 / 外科侵襲 / 感染 / 肝転移 / 制御性T細胞 / IL-10 / TGF-β / エンドトキシン吸着療法 / Interleukin-18 / IL-18受容体 / 病原性 / 胃内起因菌 / 胃がん細胞 / Proteus mirabillis / cell proliferation / MKN45 / 薬剤耐性菌 / 発光細菌 / MRSA / メチレンブルー / 膝関節炎 / 多剤耐性菌 / マウス / センチネルリンパ節 / ナノ粒子 / ICG / 見張りリンパ節 / 国際情報交換 / 肝再生 / 四塩化炭素 / Blast Lung Injury / 止血凝固作用 / アデノシン作用 / レーザー誘起衝撃波 / ドラッグデリバリシステム / アデノシン / 止血作用 / 抗サイトカイン作用 / 熱傷 / マイクロスキン / 感染制御 / 創傷被覆材 / 血管新生 / 機能性ナノシート / 抗菌性 / 抗菌能 / 同種皮膚 / 上皮化 / レスベラトロール / 脂肪肝 / クッパー細胞 / ADFP / 脂肪滴 / 外科学 / 外科 / 光線力学治療 / 侵襲 / 活性酸素 / 貪食 / 食細胞 / 好中球機能 / Photo dynamic therapy / 除菌療法 / H.pylori / H.pylori感染症 / H.pylori除菌 / 免疫麻痺 / エンドトキシン / 血液浄化療法 / 敗血症性免疫不全 / 動物敗血症モデル / 小動物用カラム / ポリミキシンB / 胃がん / 動物実験 / リンパ節転移 / 幹細胞移植 / 薬剤輸送 / 塩基性線維芽細胞成長因子 / 線維芽細胞成長因子 / 遺残ガーゼ / 銀繊維 / 渦電流 / リスクマネジメント / 生分解性金属 / ステープル / マグネシウム合金 / 自動縫合器 / 生分解性 / 水素ガス / 新規医療機器 / ステント / 脂質代謝 / 非アルコール性脂肪性肝炎 / コレステロール代謝 / NKT cells / NASH / AKI / CKD / C-reactive protein (CRP) / 救急医療 / 出血性ショック / 病院前治療 / 蘇生輸血 / 小児がん / ICGラクトソーム / 光温熱治療 / ドラッグデリバリーシステム / 神経芽腫 / 内視鏡 / 光温熱療法 / DDS / 小児外科学 / 小児腫瘍学 / ピオグリタゾン / 貪食細胞 / 解糖 / アセトアミノフェン / 貪食能 / 白血球分画 / サイトカイン / CD4陽性T cell / regulatory T cell / PD-1 / PD-L1 / CD4+T cell / 免疫不全 / 抗腫瘍活性 / 周術期管理 / 大腸がん / 転移性肝がん / 免疫療法 / 抗腫瘍効果 / 殺菌活性 / テレメディスン / 遠隔医療支援 / 自動問診 / AI / 情報共有 / 遠隔医療 / 小児外科 / セキュア / 自動問診ツール / 通信 / 集約化 / 腫瘍 / 大量肝切除 / 肝切除後肝不全 / 蛍光色素 / 蛍光タンパク / 重症病態 / ミトコンドリア / 品質管理 / 生体防御 / 炎症 / 抑うつ症状 / リポ多糖 / ミクログリア / 川崎病 / 血管炎 / 好中球サブセット / malaria / immunological tolerance / macrophage / LPSプレコンディショニング / 貪食細胞機能強化 / マラリア / 外傷 / DIC / 人工酸素運搬体 / 産科危機的出血 Less

ミトコンドリア機能と品質管理機構から捉える重症病態の分子病態研究Ongoing
- Principal Investigator
  
  宮崎裕美
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  National Defense Medical College
新規LXR刺激物質を用いた肝臓免疫細胞の機能解析Ongoing
- Principal Investigator
  
  中島弘幸
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  National Defense Medical College
リポ多糖の前投与がミクログリアを介した抑うつ症状の発症を抑制するメカニズムの研究Ongoing
- Principal Investigator
  
  古賀農人
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  National Defense Medical College
川崎病血管炎における好中球サブセット動態の解析と重症度予測への応用Ongoing
- Principal Investigator
  
  竹下誠一郎
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Defense Medical College
LPSプレコンディショニングによるマラリア重篤化抑制手法の確立Ongoing
- Principal Investigator
  
  小野岳史
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  National Defense Medical College
Treatment of trauma induced coagulopathy with H12-ADP-liposomeOngoing
- Principal Investigator
  
  萩沢康介
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  National Defense Medical College
妊娠家兎を用いた危機的産科出血に対する人工酸素運搬体投与による救命効果の研究Ongoing
- Principal Investigator
  
  結城由香子
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Saitama Medical University
Preventive effect of postoperative liver failure and promotion of liver regeneration after massive hepatectomy by LPS toleranceOngoing
- Principal Investigator
  
  星川真有美
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  The University of Tokyo
細胞担持ナノシートと蛍光遺伝子導入を用いた新しい脂肪由来幹細胞移植法の研究Ongoing
- Principal Investigator
  
  青木伸峰
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56070:Plastic and reconstructive surgery-related
- Research Institution
  Nippon Medical School
  National Defense Medical College
Novel therapeutic strategy against drug-resistant bacterial sepsis in compromised hosts focusing on enhancing bactericidal activity of macrophagesPrincipal InvestigatorOngoing
- Principal Investigator
  
  木下学
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  National Defense Medical College
Mechanism of augmented phagocytic activity in liver by pioglitazone treatment
- Principal Investigator
  
  NAKASHIMA Masahiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  National Defense Medical College
Compromised hostでの免疫不全の病態解析と高度侵襲対策Ongoing
- Principal Investigator
  
  小野聡
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Tokyo Medical University
Anti-tumor activity in LPS tolerance and development of new technology on clinical application of tolerance
- Principal Investigator
  
  MORIYA TOMOYUKI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Saitama Medical University
The therapeutic strategy for burn-induced immunosuppression: PPARgamma activation for control of innate immune response
- Principal Investigator
  
  MIYAZAKI HIROMI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  National Defense Medical College
Challenge to Optimize allocation of Pediatric Surgical Resources by using Remote Medical Platform
- Principal Investigator
  
  Shirota Chiyoe
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Research Field
  
  Society medicine, Nursing, and related fields
- Research Institution
  Nagoya University
Development of a new biodegradable magnesium alloy for medical equipment
- Principal Investigator
  
  UCHIDA HIROO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical engineering assessment
- Research Institution
  Nagoya University
The function of Kupffer cells in cholesterol metabolism
- Principal Investigator
  
  Nakashima Hiroyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  National Defense Medical College
The effect for C-reactive protein (CRP) for sever sepsis
- Principal Investigator
  
  YOKOMURO Shigeki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Nippon Medical School
Combination therapy using fibrinogen gamma-chain peptide-coated, ADP-encapsulated liposomes and hemoglobin vesicles for trauma-induced massive hemorrhage
- Principal Investigator
  
  Hagisawa Kohsuke
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  National Defense Medical College
Development of a next generation photothermal therapy using a light-absorbing drug that selectively accumulates in lesions for pediatric cancer
- Principal Investigator
  
  TAINAKA Takahisa
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pediatric surgery
- Research Institution
  Nagoya University
Photodynamic therapy using nanoparticle loaded with indocyanine green for experimental peritoneal dissemination of gastric cancer
- Principal Investigator
  
  Tsujimoto Hironori
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  National Defense Medical College
Transplantation of adipose-derived stem cell using the absorbable nanosheet.
- Principal Investigator
  
  AOKI SHIMPO
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Plastic surgery
- Research Institution
  National Defense Medical College
Development of Retained Surgical Gauze Detection System before Closing Surgical Incisions.
- Principal Investigator
  
  Hinoki Akinari
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical and hospital managemen
- Research Institution
  Nagoya University
Infection control based on photodynamic effect and new treatment for pressure ulcer by promoting wound healing
- Principal Investigator
  
  Morimoto Yuji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  National Defense Medical College
The therapeutic strategy for burn-induced immunosuppression: Regulation of phagocytes function.
- Principal Investigator
  
  MIYAZAKI Hiromi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  National Defense Medical College
Novel antioxidant therapy for radiation-induced injuriesPrincipal Investigator
- Principal Investigator
  
  Kinoshita Manabu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  National Defense Medical College
Photo dynamic therapy for eradication of Helicobacter pylori
- Principal Investigator
  
  Hiraki Shuichi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  National Defense Medical College
Blood purification for sepsis-induced immunoparalysis
- Principal Investigator
  
  ONO SATOSHI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Tokyo Medical University
Management against surgical stress in compromised hostsPrincipal Investigator
- Principal Investigator
  
  Kinoshita Manabu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Emergency medicine
- Research Institution
  National Defense Medical College
Role of the macrophages in non-alcoholic steatohepatitis and impaired glucose tolerance
- Principal Investigator
  
  Nakashima Hiroyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  National Defense Medical College
The Novel Hemostatic and Tissue Protective Treatment Elucidating the Pathophysiology of Blast Lung Injury
- Principal Investigator
  
  HAGISAWA KOHSUKE
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  National Defense Medical College
A novel therapeutic approach to severe burns by microskin grafts combined with ultra-thin nanosheets
- Principal Investigator
  
  SAITOH Diazoh
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  National Defense Medical College
Resveratrol ameliorates high-fat-diet-induced fatty liver by increasing CD68 positive Kupffer cells.
- Principal Investigator
  
  Nishikawa Kahoko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrated Nutrition Science
- Research Institution
  Chuo University
  National Defense Medical College
Photodynamic therapy using nanoparticle loaded with indocyanine green for experimental metastasis model of gastric cancer
- Principal Investigator
  
  TSUJIMOTO Hironori
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  National Defense Medical College
Surgical stress induces immunosuppression and this condition contributes to tumor growth
- Principal Investigator
  
  ONO Satoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  National Defense Medical College
Bacterial pathogen Helicobacter pylori may augment gene expressions of TLR4 and TLR5 on cancer cells under coexistence with another gastric bacteria Proteus mirabilis
- Principal Investigator
  
  NISHIKAWA Kahoko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  防衛医科大学校
   National Defense Medical College
Photodynamic diagnosis and treatment for local multiple-drug-resistant bacterial infection using photosensitizers that preferably accumulate into bacteria.
- Principal Investigator
  
  MORIMOTO YUJI
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  National Defense Medical College
Mechanical analyses and treatment of immunodeficiency following burn injuryPrincipal Investigator
- Principal Investigator
  
  KINOSHITA Manabu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  National Defense Medical College

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Book

[Book] Vitamin C2017
- Author(s)
  Yamamoto T, Kinoshita M
- Total Pages
  25
- Publisher
  INTEC
- Data Source
  KAKENHI-PROJECT-26670569
[Book] エンドトキシン・自然免疫研究192016
- Author(s)
  小野　聡、木下　学、池田寿昭
- Total Pages
  60
- Publisher
  医学図書出版
- Data Source
  KAKENHI-PROJECT-26670795
[Book] インフルエンザとの戦い2011
- Author(s)
  木下学
- Publisher
  太陽美術
- Data Source
  KAKENHI-PROJECT-22592027
[Book] Th1とTh2, サイトカインとケモカイン, 組織傷害と免疫,病態のしくみがわかる免疫学2010
- Author(s)
  木下学,関修司,阿保徹編
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-22592027
[Book] 病態のしくみがわかる免疫学2010
- Author(s)
  木下学
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Oral ascorbic acid 2-glucoside prevents coordination disorder induced via laser-induced shock waves in rat brain2020
- Author(s)
  Takaaki Maekawa, Takahiro Uchida, Yuka Nakata-Horiuchi, Hiroaki Kobayashi, Satoko Kawauchi, Manabu Kinoshita, Daizoh Saitoh, Shunichi Sato
- Journal Title
  
  PLoS ONE
  
  Volume: 15
- DOI
  10.1371/journal.pone.0230774
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08986, KAKENHI-PROJECT-18H02907
[Journal Article] The reduced bactericidal activity of neutrophils as an incisive indicator of water-immersion restraint stress and impaired exercise performance in mice.2019
- Author(s)
  Kinoshita M, Nakashima, H, Nakashima M, Koga M, Toda H, Koiwi K, Morimoto Y, Miyazaki H, Saitoh D, Suzuki H, Seki S
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Pages: 4562-4562
- DOI
  10.1038/s41598-019-41077-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02907, KAKENHI-PROJECT-17K08611, KAKENHI-PROJECT-17K10682, KAKENHI-PROJECT-17K11602
[Journal Article] Development of new biokinetic-dosimetric models for the simulation of iodine blockade in the case of radioiodine exposure in man2019
- Author(s)
  Rump A, Eder S, Lamkowski A, Kinoshita M, Yamamoto T, Abend M, Shinomiya N, Port M
- Journal Title
  
  Drug Res
  
  Volume: 69(11) Pages: 583-597
- DOI
  10.1055/a-0960-5590
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02685, KAKENHI-PROJECT-18H02907
[Journal Article] Combination therapy using fibrinogen γ-chain peptide-coated, ADP-encapsulated liposomes and hemoglobin vesicles for trauma-induced massive hemorrhage in thrombocytopenic rabbits2019
- Author(s)
  K. Hagisawa, M. Kinoshita, M. Takikawa, S. Takeoka, D. Saitoh, S. Seki, H. Sakai
- Journal Title
  
  Transfusion
  
  Volume: 59(10) Pages: 3186-3196
- DOI
  10.1111/trf.15427
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H02087, KAKENHI-PROJECT-18H02907
[Journal Article] Immune mechanisms underlying susceptibility to endotoxin shock in aged hosts: implication in age-augmented generalized Shwartzman reaction. (review)2019
- Author(s)
  Kinoshita M, Nakashima M, Nakashima H, Seki S
- Journal Title
  
  Int J Mol Sci
  
  Volume: 20 Pages: 3260-3260
- DOI
  10.3390/ijms20133260
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02907, KAKENHI-PROJECT-17K10682
[Journal Article] In situ Transplantation of Adipose Tissue-Derived Stem Cells Organized on Porous Polymer Nanosheets for Murine Skin Defects.2019
- Author(s)
  Nishiwaki Keisuke、Aoki Shimpo、Kinoshita Manabu、Kiyosawa Tomoharu、Suematsu Yoshitaka、Takeoka Shinji、Fujie Toshinori
- Journal Title
  
  J. Biomed. Mater. Res. B Appl. Biomater.
  
  Volume: 印刷中 Pages: 1363-1371
- DOI
  10.1002/jbm.b.34228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K20116, KAKENHI-PLANNED-18H05469, KAKENHI-PROJECT-18H02907, KAKENHI-PROJECT-15K10961, KAKENHI-PROJECT-17K10682
[Journal Article] Pioglitazone improves phagocytic activity of liver recruited macrophages in elderly mice possibly by promoting glucose catabolism.2019
- Author(s)
  Nakashima M, Kinoshita M, Nakashima H, Kotani A, Ishikiriyama T, Kato S, Hiroi S, Seki S
- Journal Title
  
  Innate Immunity
  
  Volume: 25 Pages: 356-368
- DOI
  10.1177/1753425919849620
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02907, KAKENHI-PROJECT-17K08611, KAKENHI-PROJECT-17K10682
[Journal Article] On-site rapid detection of antibacterial activity of neutrophils using freeze-dried bacteria2019
- Author(s)
  Tanabe Koji、Kinoshita Manabu、Nakashima Masahiro、Kariya Koki、Yokokawa Masatoshi、Morimoto Yuji、Suzuki Hiroaki
- Journal Title
  
  Medical Device Sensor
  
  Volume: 00
- DOI
  10.1002/mds3.10030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02907
[Journal Article] Combination therapy using fibrinogen gamma-chain peptide-coated, ADP-encapsulated liposomes and hemoglobin vesicles for trauma-induced massive hemorrhage in thrombocytopenic rabbits2019
- Author(s)
  Hagisawa K, Kinoshita M, Takikawa M, Takeoka S, Saitoh D, Seki S, Sakai H
- Journal Title
  
  Transfusion
  
  Volume: 59
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11435
[Journal Article] The efficacy of basic fibroblast growth factor-loaded poly(lactic-co-glycolic acid) nanosheet for mouse wound healing.2018
- Author(s)
  Shimpo Aoki MD, PhD Mao Fujii MSc Toshinori Fujie PhD Keisuke Nishiwaki MSc Hiromi Miyazaki PhD Daizoh Saitoh MD, PhD Shinji Takeoka PhD Tomoharu Kiyosawa MD, PhD Manabu Kinoshita MD, PhD
- Journal Title
  
  Wound Repair and Regeneration.
  
  Volume: 25(6) Pages: 100-1016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10961
[Journal Article] 出血性ショックと凝固障害を人工血液で制御する2018
- Author(s)
  萩沢康介、木下学
- Journal Title
  
  Shock（第32回日本Shock学会総会プロシーディング）
  
  Volume: 32 Pages: 14-17
- Data Source
  KAKENHI-PROJECT-16K11435
[Journal Article] Efficacy of Resuscitative Transfusion With Hemoglobin Vesicles in the Treatment of Massive Hemorrhage in Rabbits With Thrombocytopenic Coagulopathy and Its Effect on Hemostasis by Platelet Transfusion2018
- Author(s)
  Hagisawa, Kohsuke; Kinoshita, Manabu; Takase, Bonpei; Hashimoto, Kenichi; Saitoh, Daizoh; Seki, Shuhji; Nishida, Yasuhiro; Sakai, Hiromi
- Journal Title
  
  SHOCK
  
  Volume: in press Pages: 324-330
- DOI
  10.1097/shk.0000000000001042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11435, KAKENHI-PROJECT-18H02907
[Journal Article] In vivo Lipopolysaccharide Tolerance Recruits CD11b+ Macrophages to the Liver with Enhanced Bactericidal Activity and Low Tumor Necrosis Factor-Releasing Capability, Resulting in Drastic Resistance to Lethal Septicemia.2017
- Author(s)
  Kinoshita Manabu、Miyazaki Hiromi、Nakashima Hiroyuki、Nakashima Masahiro、Nishikawa Makoto、Ishikiriyama Takuya、Kato Shoichiro、Iwaya Keiichi、Hiroi Sadayuki、Shinomiya Nariyoshi、Seki Shuhji
- Journal Title
  
  J Innate Immun
  
  Volume: 9 Pages: 493-510
- DOI
  10.1159/000475931
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08751, KAKENHI-PROJECT-15H04315
[Journal Article] In vivo LPS tolerance recruits CD11b+ macrophages to the liver with enhanced bactericidal activity and low TNF-releasing capability, resulting in drastic resistance to lethal septicemia.2017
- Author(s)
  Kinoshita M, Miyazaki H, Nakashima, H, Nakashima M, Nishikawa M, Ishikiriyama T, Kato S, Iwaya K, Hiroi S, Shinomiya N, Seki S.
- Journal Title
  
  J. Innate Immun.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670569
[Journal Article] Apoptosis induction of poly-S-nitrosated human serum albumin in resistant solid tumor under hypoxia can be restored by phosphodiesterase 5 inhibition.2017
- Author(s)
  Ikeda M, Ishima Y, Chuang VTG, Ikeda T, Kinoshita R, Watanabe H, Ishida T, Otagiri M, Maruyama T
- Journal Title
  
  Nitric Oxide.
  
  Volume: S1089-8603 Pages: 28-34
- DOI
  10.1016/j.niox.2017.04.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670569, KAKENHI-PROJECT-15K08076
[Journal Article] Fibrinogen γ-Chain Peptide-Coated Adenosine 5' Diphosphate-Encapsulated Liposomes Rescue Mice From Lethal Blast Lung Injury via Adenosine Signaling.2016
- Author(s)
  Hagisawa K, Miyawaki H, Kinoshita M, Miyazaki H, Yanagawa R, Doi M, Takeoka S, Suzuki H, Seki S, Saitoh D, Nishida Y, Handa M.
- Journal Title
  
  Critical Care Medicine
  
  Volume: 44
- DOI
  10.1097/ccm.0000000000001707
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25462843
[Journal Article] Polylactic acid nanosheets in prevention of postoperative intestinal adhesion and their effects on bacterial propagation in an experimental model.2016
- Author(s)
  Hinoki A, Saito A, Kinoshita M, Yamamoto J, Saitoh D, Takeoka S.
- Journal Title
  
  Br J Surg
  
  Volume: 103 Pages: 692-700
- DOI
  10.1002/bjs.10122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462844
[Journal Article] Development of a ubiquitously transferrable silver-nanoparticles-loaded polymer nanosheet as an antimicrobial coating.2016
- Author(s)
  Keisuke Ito, Akihiro Saito, Toshinori Fujie, Hiromi Miyazaki, Manabu Kinoshita,Daizoh Saitoh, Shinya Ohtsubo, Shinji Takeoka
- Journal Title
  
  J. Biomed. Mater. Res. Part B.
  
  Volume: 103 Pages: 585-593
- DOI
  10.1002/jbm.b.33429
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25289252, KAKENHI-PROJECT-25462844, KAKENHI-PROJECT-15H05355, KAKENHI-PROJECT-25293369
[Journal Article] Activation and increase of radio-sensitive CD11b+ recruited Kupffer cells/macrophages in diet-induced steatohepatitis in FGF5 deficient mice2016
- Author(s)
  Nakashima H, Nakashima M, Kinoshita M, Ikarashi M, Miyazaki H, Hanaka H, Imaki J, Seki S.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Pages: 34466-34466
- DOI
  10.1038/srep34466
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462773, KAKENHI-PROJECT-16K08751, KAKENHI-PROJECT-26293295
[Journal Article] Treatment of irradiated mice with high-dose ascorbic acid reduced lethality.2015
- Author(s)
  Sato T, Kinoshita M, Yamamoto T, Ito M, Nishida T, Takeuchi M, Saitoh D, Seki S, Mukai Y.
- Journal Title
  
  PLoS ONE
  
  Volume: 10
- DOI
  10.1371/journal.pone.0117020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26670569, KAKENHI-PROJECT-25293369
[Journal Article] Polythiol-containing, recombinant mannosylated-albumin is a superior CD68+/CD206+ Kupffer cell-targeted nanoantioxidant for treatment of two acute hepatitis models.2015
- Author(s)
  Maeda H, Hirata K, Watanabe H, Ishima Y, Chuang VT, Taguchi K, Inatsu A, Kinoshita M, Tanaka M, Sasaki Y, Otagiri M, Maruyama T.
- Journal Title
  
  J. Pharmacol. Exp. Ther.
  
  Volume: 352 Pages: 244-257
- DOI
  10.1124/jpet.114.219493
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-25460190, KAKENHI-PROJECT-25670085, KAKENHI-PROJECT-15K08076, KAKENHI-PROJECT-26670569, KAKENHI-PROJECT-25293173, KAKENHI-PROJECT-25293369
[Journal Article] Burn-evoked reactive oxygen species immediately after injury are crucial to restore the neutrophil function against postburn infection in mice.2015
- Author(s)
  Miyazaki H, Kinoshita M, Ono S, Seki S, Saitoh D
- Journal Title
  
  Shock
  
  Volume: 44 Pages: 252-257
- DOI
  10.1097/shk.0000000000000404
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462773, KAKENHI-PROJECT-25293369
[Journal Article] Photodynamic TherapyMediates Innate Immune Responses via Fibroblast-Macrophage Interactions2015
- Author(s)
  4.Zulaziz N, Azhim A, Himeno N, Tanaka M, Satoh Y, Kinoshita M, Miyazaki H, Saitoh D, Shinomiya N, Morimoto Y.
- Journal Title
  
  Human Cell
  
  Volume: 28 Pages: 159-166
- DOI
  10.1007/s13577-015-0118-2
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670569, KAKENHI-PROJECT-15H04315, KAKENHI-PROJECT-25293369, KAKENHI-PROJECT-26293295
[Journal Article] Pharmacokinetic properties of single and repeated injection of liposomal platelet substitute in a rat model of red blood cell transfusion-induced dilutional thrombocytopenia.2015
- Author(s)
  Hashimoto M, Taguchi K, Ogaki S, Watanabe H, Kinoshita M, Nishikawa K, Takeoka S, Ikeda Y, Handa M, Otagiri M, Maruyama T.
- Journal Title
  
  J. Pharm. Sci.
  
  Volume: 104 Pages: 3968-3976
- DOI
  10.1002/jps.24607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293369
[Journal Article] Sustainable antimicrobial effect of silver sulfadiazine-loaded nanosheets on infection in a mouse model of partial-thickness burn injury2015
- Author(s)
  Ito K, Saito A, Fujie T, Nishiwaki K, Miyazaki H, Kinoshita M, Saitoh D, Ohtsubo S, Takeoka S.
- Journal Title
  
  Acta Biomaterialia
  
  Volume: 24 Pages: 87-95
- DOI
  10.1016/j.actbio.2015.05.035
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25462844, KAKENHI-PROJECT-15H05355, KAKENHI-PROJECT-25289252, KAKENHI-PROJECT-25293369
[Journal Article] Mouse CD11b+Kupffer Cells Recruited from Bone Marrow Accelerate Liver Regeneration after Partial Hepatectomy2015
- Author(s)
  Nakashima, H.　Kinoshita, M.　Seki, S.
- Journal Title
  
  PLoS One
  
  Volume: 10
- DOI
  10.1371/journal.pone.0136774
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460508
[Journal Article] Treatment with fibrinogen -chain peptide-coated, ADP-encapsulated liposomes as an infusible haemostatic agent against active liver bleeding in acute thrombocytopenic rabbits.2015
- Author(s)
  Hagisawa K, Nishikawa K, Yanagawa R, Kinoshita M, Doi M, Suzuki H, Iwaya K, Saitoh D, Seki S, Takeoka S, Handa M, Nishida Y.
- Journal Title
  
  Transfusion
  
  Volume: 55 Pages: 314-25
- DOI
  10.1111/trf.12829
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462843, KAKENHI-PROJECT-25504021, KAKENHI-PROJECT-25293369
[Journal Article] Catecholamine vasomotive effect rescue mice with blast lung injury caused by laser-induced shock wave in super acute phase.2015
- Author(s)
  Miyawaki H, Saito D, Hagisawa K, Noguchi M, Sato S, Kinoshita M, Miyazaki H, Sato Y, Harada N, Sakamoto T.
- Journal Title
  
  Int Care Med Exp
  
  Volume: 32 Pages: 32-32
- DOI
  10.1186/s40635-015-0069-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462843, KAKENHI-PROJECT-25293369
[Journal Article] ビタミンCによる放射線傷害軽減化対策ーより安全で使いやすい防護剤の開発ー2015
- Author(s)
  木下学、山本哲生、伊藤靖利、佐藤智人
- Journal Title
  
  Isotope News
  
  Volume: 739 Pages: 2-8
- Data Source
  KAKENHI-PROJECT-26670569
[Journal Article] Burn-evoked reactive oxygen species immediately after injury are crucial to restore the neutrophil function against post-burn infection in mice2015
- Author(s)
  Miyazaki H, Kinoshita M, Ono S, Seki S, Saitoh D.
- Journal Title
  
  Shock
  
  Volume: 44 Pages: 252-257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670795
[Journal Article] CD47 is an adverse prognostic factor and a therapeutic target in gastric cancer.2015
- Author(s)
  Yoshida K, Tsujimoto H, Matsumura K, Kinoshita M, Takahata R, Matsumoto Y, Hiraki S, Ono S, Seki S, Yamamoto J, Hase K.
- Journal Title
  
  Cancer Medicine
  
  Volume: 4 Pages: 1322-1333
- DOI
  10.1002/cam4.478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293369
[Journal Article] Resveratrol increases CD68+ Kupffer cells co-localized with adipose differentiation-related protein (ADFP) and ameliorates high-fat-diet-induced fatty liver in mice.2015
- Author(s)
  Nishikawa K, Iwaya K, Kinoshita M, Fujiwara Y, Akao M, Sonoda M, Thiruppathi S, Suzuki T, Hiroi S, Seki S, Sakamoto T.
- Journal Title
  
  Mol. Nutr. Food Res.
  
  Volume: 12 Pages: 1155-1170
- DOI
  10.1002/mnfr.201400564
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590457, KAKENHI-PROJECT-25504021, KAKENHI-PROJECT-25460508, KAKENHI-PROJECT-25293369
[Journal Article] 衝撃波による致死的肺出血マウスに対する人工血小板（H12-ADP-liposome）の救命効果2014
- Author(s)
  萩沢康介、木下学、宮脇博基、佐藤俊一、鈴木英紀、土井麻美、武岡真司、小野聡、斎藤大蔵、西田育弘
- Journal Title
  
  Shock　（日本ショック学会雑誌）
  
  Volume: 29 Pages: 1-8
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25462843
[Journal Article] Involvement of the TNF and FasL Produced by CD11b Kupffer Cells/Macrophages in CCl4-Induced Acute Hepatic Injury2014
- Author(s)
  Sato A, Nakashima H, Nakashima M, Ikarashi M, Nishiyama K, Kinoshita M, Seki S
- Journal Title
  
  PLOS ONE
  
  Volume: 9
- DOI
  10.1371/journal.pone.0092515
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293369, KAKENHI-PROJECT-25460508, KAKENHI-PROJECT-26670569
[Journal Article] A combination of pre- and post-exposure ascorbic acid rescues mice from radiation-induced lethal gastrointestinal damage.2014
- Author(s)
  Ito Y, Kinoshita M, Yamamoto T, Sato T, Obara T, Saitoh D, Seki S, Takahashi Y.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 14 Pages: 19618-19635
- DOI
  10.3390/ijms141019618
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293369, KAKENHI-PROJECT-26670569
[Journal Article] 放射線被曝時のIntestinal Failureとその対策2014
- Author(s)
  木下学
- Journal Title
  
  消化と吸収
  
  Volume: 36 Pages: 341-347
- Data Source
  KAKENHI-PROJECT-26670569
[Journal Article] Immunoenhancing therapy with interleukin-18 against bacterial infection in immunocompromised hosts after severe surgical stress2013
- Author(s)
  Kinoshita M, Miyazaki H, Ono S, Seki S
- Journal Title
  
  J. Leukocyte. Biol
  
  Volume: 93 Pages: 689-698
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Fragmentation of Poly(lactic acid) Nanosheets and Their Patchwork Treatment for Burn Wounds2013
- Author(s)
  Okamura, Y., Kabata, K., Kinoshita, M., iyazaki H, Saito A, Fujie T, Ohtsubo S, Saitoh, D., and Takeoka, S
- Journal Title
  
  Adv. Mater
  
  Volume: 25 Pages: 545-551
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Linezolid and vancomycin decrease the therapeutic effect of methylene blue-photodynamic therapy in a mouse model of MRSA bacterial arthritis.2013
- Author(s)
  Tanaka, M.　Mroz, P.　Dai, T.　Huang, L.　Morimoto, Y.　Kinoshita, M.　Yoshihara, Y.　Shinomiya, N.　Seki, S.　Nemoto, K.　Hamblin, M. R.
- Journal Title
  
  Photochem. Photobiol.
  
  Volume: 89(3) Pages: 679-682
- DOI
  10.1111/php.12040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300365, KAKENHI-PROJECT-23659599, KAKENHI-PROJECT-23659628, KAKENHI-PROJECT-25293369
[Journal Article] ナノ粒子による外傷性大量出血の止血治療2013
- Author(s)
  萩沢康介、木下学、西川可穂子、柳川錬平、土井麻実、西田育夫、齋藤大蔵
- Journal Title
  
  Bio Industry
  
  Volume: 30 Pages: 3-9
- Data Source
  KAKENHI-PROJECT-25293369
[Journal Article] Application of poly-L-lactic acid nanosheet as a material for wound dressing.2013
- Author(s)
  Aoki, S
- Journal Title
  
  Plast Reconstr Surg
  
  Volume: 131 Pages: 236-240
- DOI
  10.1097/prs.0b013e3182789c79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592027, KAKENHI-PROJECT-24590457, KAKENHI-PROJECT-25293369
[Journal Article] 外科侵襲によるimmunoparalysisとその制御2013
- Author(s)
  小野　聡、平木修一、辻本広紀、木下学、齋藤大蔵
- Journal Title
  
  侵襲と免疫
  
  Volume: 22 Pages: 7-18
- Data Source
  KAKENHI-PROJECT-25293369
[Journal Article] Tissue Engineering of the Stomach.2013
- Author(s)
  Maemura T, Shin M, Kinoshita M
- Journal Title
  
  J Surg Res
  
  Volume: 183 Pages: 285-295
- DOI
  10.1016/j.jss.2013.02.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293369
[Journal Article] Effective control of massive venous bleeding by “multi-overlapping therapy” using polysaccharide nanosheets in rabbit inferior vena cava injury model.2013
- Author(s)
  Hagisawa K, Saito A, Kinoshita M, Fujie T, Otani N, Shono S, Park YK, Takeoka S
- Journal Title
  
  J. Vasc. Surg: Venous and Lymphatic Disorders.
  
  Volume: 1 Pages: 289-297
- DOI
  10.1016/j.jvsv.2013.04.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293369
[Journal Article] Novel therapeutic usage of polysaccharide nanosheets for aracinoid plasty and reinforcement of venous tensile strength in rat microneurosurgery2013
- Author(s)
  Otani N, Kinoshita M, Fujie T, Saito A, Takeoka S, Saitoh D, Hagisawa K, Nawashiro H, Shima K
- Journal Title
  
  J. Clin. Neurosci
  
  Volume: 20 Pages: 301-305
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] 人工血小板H12(ADP)リポソームを用いた急性血小板減少病態への止血・救命対策.2013
- Author(s)
  西川可穂子、萩沢康介、柳川錬平、土井麻実、鈴木英紀、齋藤大蔵、阪本敏久、武岡真司、半田誠、木下学
- Journal Title
  
  人工血液
  
  Volume: 21 Pages: 60-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293369
[Journal Article] Removal of increased circulating CD4+CD25+Foxp3+ regulatory T cells in patients with septic shock using hemoperfusion with polymyxin B-immobilized fibers2013
- Author(s)
  Ono, S
- Journal Title
  
  Surgery
  
  Volume: 153 Pages: 262-271
- DOI
  10.1016/j.surg.2012.06.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592027, KAKENHI-PROJECT-25293369
[Journal Article] Immunoenhancing therapy with interleukin-18 against bacterial infection in immunocompromised hosts after severe surgical stress.2013
- Author(s)
  Kinoshita M, Miyazaki H, Ono S, Seki S
- Journal Title
  
  J. Leukocyte. Biol.
  
  Volume: 93 Pages: 689-698
- DOI
  10.1189/jlb.1012502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293369
[Journal Article] Linezolid and vancomycin decrease the therapeutic effect of methylene blue-photodynamic therapy in a mouse model of MRSA bacterial arthritis2013
- Author(s)
  Tanaka M, Mroz P, Dai T, Huang L, Morimoto Y, Kinoshita M, Yoshihara Y, Shinomiya N, Seki S, Nemoto K, Hamblin MR
- Journal Title
  
  Photochem Photobiol
  
  Volume: 89(3) Pages: 679-682
- Data Source
  KAKENHI-PROJECT-23659628
[Journal Article] Glucocorticoid receptor-dependent immunomodulatory effect of ursodeoxycholic acid on liver lymphocytes in mice.2013
- Author(s)
  Takigawa T, Miyazaki H, Kinoshita M, Kawarabayashi N, Nishiyama K, Hatsuse K, Ono S, Saitoh D, Seki S, Yamamoto J
- Journal Title
  
  Am J Physiol-Gastr L
  
  Volume: 305
- DOI
  10.1152/ajpgi.00205.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293369
[Journal Article] Activation of CD11b+ Kupffer cells/macrophages as a common cause for exacerbation of TNF/ Fas-ligand-dependent hepatitis in hypercholesterolemic mice.2013
- Author(s)
  Nakashima, H
- Journal Title
  
  PLoS ONE
  
  Volume: 8
- DOI
  10.1371/journal.pone.0049339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592027, KAKENHI-PROJECT-25293369
[Journal Article] The effect of synthetic C-reactive protein on the in vitro immune response of human PBMCs stimulated with bacterial reagents.2013
- Author(s)
  Sato A, Nakashima H, Kinoshita M, Nakashima M, Ogawa Y, Shono S, Ikarashi M, Seki S
- Journal Title
  
  Inflammation
  
  Volume: 36 Pages: 781-792
- DOI
  10.1007/s10753-013-9604-4
- NAID
  130004638709
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293369
[Journal Article] Fragmentation of Poly(lactic acid) Nanosheets and Their Patchwork Treatment for Burn Wounds.2013
- Author(s)
  Okamura, Y
- Journal Title
  
  Adv. Mater.
  
  Volume: 25 Pages: 545-551
- DOI
  10.1002/adma.201202851
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592027, KAKENHI-PROJECT-25293369
[Journal Article] Activation of CD11b+ Kupffer cells/macrophages as a common cause for exacerbation of TNF/ Fas-ligand-dependent hepatitis in hypercholesterolemic mice2013
- Author(s)
  Nakashima H, Ogawa Y, Shono S, Kinoshita M, Nakashima M, Sato A, Ikarashi M, Seki S
- Journal Title
  
  PLoS ONE
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Application of poly-L-lactic acid nanosheet as a material for wound dressing2013
- Author(s)
  Aoki S, Kinoshita M, Miyazaki H, Saito A, Fujie T, Iwaya K, Takeoka S, Saitoh D
- Journal Title
  
  Plast Reconstr Surg
  
  Volume: 131 Pages: 236-240
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Removal of increased circulating CD4+CD25+Foxp3+ regulatory T cells in patients with septic shock using hemoperfusion with polymyxin B-immobilized fibers2013
- Author(s)
  Ono S, Kimura A, Hiraki S, Takahata R, Tsujimoto H, Kinoshita M, Miyazaki H, Yamamoto J, Hase K, Saitoh D
- Journal Title
  
  Surgery
  
  Volume: 153 Pages: 262-271
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] 【光線力学診断・治療の最新動向】 PDT における好中球の重要性2013
- Author(s)
  守本祐司, 田中優砂光, 木下学
- Journal Title
  
  日本レーザー医学会誌
  
  Volume: 34(2) Pages: 133-137
- Data Source
  KAKENHI-PROJECT-23659628
[Journal Article] Immunoenhancing therapy with interleukin-18 against bacterial infection in immunocompromised hosts after severe surgical stress2013
- Author(s)
  Kinoshita M, Miyazaki H, Ono S, Seki S
- Journal Title
  
  J Leukoc Biol
  
  Volume: 93 Pages: 689-698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591886
[Journal Article] 合成CRPのヒト末梢血単核球に対する炎症性サイトカイン産生抑制効果と抗腫瘍活性増強効果2013
- Author(s)
  佐藤　厚志、木下学、中島弘幸、中島正裕、五十嵐正巳、関　修司
- Journal Title
  
  外科と代謝・栄養
  
  Volume: 47 Pages: 31-39
- NAID
  130004638709
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293369
[Journal Article] 人工血液、人工血小板の臨床応用2013
- Author(s)
  木下学
- Journal Title
  
  A net
  
  Volume: 18 Pages: 14-17
- Data Source
  KAKENHI-PROJECT-25293369
[Journal Article] Distinct development and functions of resident and recruited liver Kupffer cells/macrophages2013
- Author(s)
  Ikarashi M, Nakashima H, Kinoshita M, Sato A, Nakashima M, Miyazaki H, Nishiyama K, Yamamoto J, Seki S.
- Journal Title
  
  J Leukoc Biol
  
  Volume: 94 Pages: 1325-1336
- DOI
  10.1189/jlb.0313144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293369, KAKENHI-PROJECT-25460508
[Journal Article] Glucocorticoid receptor-dependent immunomodulatory effect of ursodeoxycholic acid on liver lymphocytes in mice2013
- Author(s)
  Takigawa T, Miyazaki H, Kinoshita M, Kawarabayashi N, Nishiyama K, Hatsuse K, Ono S, Saitoh D, Seki S, Yamamoto J
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol
  
  Volume: 305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591886
[Journal Article] 軍事史に学輸血用血液の重要性と人工血液への期待2013
- Author(s)
  西山靖将、柳川錬平、染田英利、妻鳥元太郎、木下学
- Journal Title
  
  防衛衛生
  
  Volume: 61 Pages: 45-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293369
[Journal Article] Novel therapeutic usage of polysaccharide nanosheets for aracinoid plasty and reinforcement of venous tensile strength in rat microneurosurgery.2013
- Author(s)
  Otani, N
- Journal Title
  
  J. Clin. Neurosci.
  
  Volume: 20 Pages: 301-305
- DOI
  10.1016/j.jocn.2012.05.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592027, KAKENHI-PROJECT-25293369
[Journal Article] Removal of increased circulating CD4+CD25+Foxp3+ regulatory T cells in patients with septic shock using hemoperfusion with polymyxin B-immobilized fibers2013
- Author(s)
  Ono S, Tsujimoto H, Kinoshita M, Miyazaki H, Hase K, Saitoh D, et al.
- Journal Title
  
  Surgery
  
  Volume: 153 Pages: 262-271
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591886
[Journal Article] Neutralization of interleukin-10 or tumor growing factor-beta decreases the percentages of CD4+CD25+Foxp3+ regulatory T cells in septic mice, thus leading to an improved survival2012
- Author(s)
  Hiraki S, Ono S, Tsujimoto H, Kinoshita M, Takahata, R., Miyazaki H., Saitoh D, Hase K
- Journal Title
  
  Surgery
  
  Volume: 151 Pages: 313-22
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Fibrinogen γ-chain peptide-coated, adenosine diphosphate-encapsulated liposomes rescue thrombocytopenic rabbits from non-compressible liver hemorrhage2012
- Author(s)
  Nishikawa K, Hagisawa K, Kinoshita M, Shono S, Katsuno S, Doi M, Yanagawa R, Suzuki H, Iwaya K, Saitoh D, Sakamoto T, Seki S, Takeoka S, Handa M
- Journal Title
  
  J Thromb Haemost
  
  Volume: 10 Pages: 2137-2148
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Neutralization of interleukin-10 or transforming growth factor-βdecreases the percentages of CD4+CD25+Foxp3+ regulatory T cells in septic mice, thereby leading to an improved survival2012
- Author(s)
  Hiraki S, Ono S, Tsujimoto H, Kinoshita M, Miyazaki H, Saitoh D, Hase K
- Journal Title
  
  Surgery
  
  Volume: 151 Pages: 313-322
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591886
[Journal Article] The postoperative serum interleukin-15 concentration correlates with organ dysfunction and the prognosis of septic patients following emergency gastrointestinal surgery2012
- Author(s)
  Kimura A, Ono S, Hiraki S, Takahata R, Tsujimoto H, Miyazaki H, Kinoshita M, Hatsuse K, Saitoh D, Hase K, Yamamoto J
- Journal Title
  
  J Surg Res
  
  Volume: 175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591886
[Journal Article] Insulin treatment directly restores neutrophil phagocytosis and bactericidal activity in diabetic mice, thereby improving surgical site infection with Staphylococcus aureus2012
- Author(s)
  Yano H, Kinoshita M, Fujino K, Nakashima M, Yamamoto Y, Miyazaki H, Hamada K, Iwaya K, Saitoh D, Seki S, Tanaka Y
- Journal Title
  
  Infect Immun
  
  Volume: 80 Pages: 4409-4416
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] 光線力学療法(PDT)の局所細菌感染症への応用化膿性関節炎モデルを用いた実験的研究2012
- Author(s)
  田中優砂光, 守本祐司, 木下学, 吉原愛雄, 四ノ宮成祥, 関修司, 斎藤大蔵, 宮崎裕美, Hamblin MR, 根本孝一
- Journal Title
  
  防衛医科大学校雑誌
  
  Volume: 37(4) Pages: 243-256
- Data Source
  KAKENHI-PROJECT-23659628
[Journal Article] Neutralization of IL-10 restores the down-regulation of IL-18 receptor on NK cells and IFN-γ production in septic mice, thus leading to an improved survival2012
- Author(s)
  Hiraki S, Ono S, Kinoshita M, Tsujimoto H, Takahata, R., Miyazaki H., Saitoh D, Seki S, Hase K
- Journal Title
  
  SHOCK
  
  Volume: 37 Pages: 177-82
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] The postoperative serum interleukin-15 concentration correlates with organ dysfunction and the prognosis of septic patients following emergency gastrointestinal surgery2012
- Author(s)
  Kimura A, Ono S, Hiraki S, Takahata R, Tsujimoto H, Miyazaki H, Kinoshita M, Hatsuse K, Saitoh D, Hase K, Yamamoto J
- Journal Title
  
  J Surg Res
  
  Volume: 175
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Therapeutic efficacy of an antibiotic-loaded nanosheet in a murine burn-wound infection model2012
- Author(s)
  Saito A, Miyazaki H, Fujie T, Ohtsubo S, Kinoshita M, Saitoh D, Takeoka S
- Journal Title
  
  Acta Biomater
  
  Volume: 8 Pages: 2932-2940
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] The postoperative serum interleukin-15 concentration correlates with organ dysfunction and the prognosis of septic patients following emergency gastrointestinal surgery2012
- Author(s)
  Kimura A, Ono S, Tsujimoto H, Miyazaki H, Kinoshita M, Saitoh D, Hase K. et al.
- Journal Title
  
  J Surg Res
  
  Volume: 175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591886
[Journal Article] Characterization of mouse liver phagocytic B cells in innate immunity2012
- Author(s)
  Nakashima M, Kinoshita M, Nakashima H, Habu Y, Miyazaki H, Hiroi S, Nakanishi K, Seki S
- Journal Title
  
  J. Leukocyte. Biol
  
  Volume: 91 Pages: 537-546
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Optimal Photosensitizers for Photodynamic Therapy of Infections Should Kill Bacteria but Spare Neutrophils2012
- Author(s)
  Tanaka M, Kinoshita M, Yoshihara Y, Shinomiya N, Seki S, Nemoto K, Hirayama T, Dai T, Huang L, Hamblin MR, Morimoto Y
- Journal Title
  
  Photochem Photobiol
  
  Volume: 88(1) Pages: 227-232
- Data Source
  KAKENHI-PROJECT-23659628
[Journal Article] The Liver as a Pivotal Innate Immune Organ2012
- Author(s)
  Seki S, Nakashima H, Kinoshita M
- Journal Title
  
  Immuno-gastroenterology
  
  Volume: 1 Pages: 76-89
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Optimal photosensitizers for photodynamic therapy of infections should kill bacteria but spare neutrophils2012
- Author(s)
  Tanaka M, Kinoshita M, Yoshihara Y, Shinomiya N, Seki S, Nemoto K, Hamblin M, Dai T, Huang L, Morimoto Y
- Journal Title
  
  Photochem. Photobiol
  
  Volume: 88 Pages: 227-32
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Neutralization of IL-10 restores the down-regulation of IL-18 receptor on NK cells and IFN-γproduction in septic mice, thus leading to an improved survival2012
- Author(s)
  Hiraki S, Ono S, Kinoshita M, Tsujimoto H, Miyazaki H, Saitoh D, Hase K
- Journal Title
  
  Shock
  
  Volume: 37 Pages: 177-182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591886
[Journal Article] Liposome-encapsulated hemoglobin attenuates cardiac dysfunction and sympathetic activity during hypohemoglobinemic shock2012
- Author(s)
  Nogami, Y., Takase, B., Kinoshita, M., Shono, S., Kaneda, S., Tanaka, Y., Kishimoto, S., Hattori, H., Ishihara, M
- Journal Title
  
  SHOCK
  
  Volume: 38 Pages: 159-164
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] 光線力学療法(PDT)の生体防御能賦活効果2012
- Author(s)
  田中優砂光, 木下学, 吉原愛雄, 四ノ宮成祥, 関修司, 根本孝一, 守本祐司
- Journal Title
  
  光アライアンス
  
  Volume: 23 Pages: 42-45
- Data Source
  KAKENHI-PROJECT-23659628
[Journal Article] Photodynamic therapy can induce a protective innate immune response against murine bacterial arthritis via neutrophil accumulation2012
- Author(s)
  Tanaka M, Mroz P, Dai T, Huang L, Morimoto Y, Kinoshita M, Yoshihara Y, Nemoto K, Shinomiya N, Seki S, Hamblin M
- Journal Title
  
  PLoS One
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] An ultra-thin poly(L-lactic acid) nanosheet as a burn-wound dressing for protection against bacterial infection2012
- Author(s)
  Miyazaki H, Kinoshita M, Saito A, Fujie T, Kabata K, Hara E, Ono S, Takeoka S, Saitoh D
- Journal Title
  
  Wound Repair Regen
  
  Volume: 20 Pages: 573-579
- NAID
  10031181844
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Neutralization of interleukin-10 or transforming growth factor-β decreases the percentages of CD4+CD25+Foxp3+ regulatory T cells in septic mice, thereby leading to an improved survival2012
- Author(s)
  Hiraki S, Ono S,Tsujimoto H, Kinoshita M, Takahata R, Miyazaki H, Saitoh D, Hase K
- Journal Title
  
  Surgery
  
  Volume: 151 Pages: 313-322
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591886
[Journal Article] Assessment of a Tissue-Engineered Gastric Wall Patch in a Rat Model2012
- Author(s)
  Maemura T, Kinoshita M, Shin M, Miyazaki H, Tsujimoto H, Ono S, Hase K, Saitoh D
- Journal Title
  
  Artif. Organs
  
  Volume: 36 Pages: 409-17
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Photodynamic therapy can induce a protective innate immune response against murine bacterial arthritis via neutrophil accumulation2012
- Author(s)
  Tanaka M, Mroz P, Dai T, Huang L, Morimoto Y, Kinoshita M, Yoshihara Y, Nemoto K, Shinomiya N, Seki S, Hamblin MR
- Journal Title
  
  PloS one
  
  Volume: 7(6)
- Data Source
  KAKENHI-PROJECT-23659628
[Journal Article] Neutralization of IL-10 restores the down-regulation of IL-18 receptor on NK cells and IFN-γ production in septic mice, thus leading to an improved survivaｌ2012
- Author(s)
  Hiraki S, Ono S, Kinoshita M, Tsujimoto H, Takahata R, Miyazaki H, Saitoh D, Seki S, Hase K.
- Journal Title
  
  Shock
  
  Volume: 37 Pages: 177-182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591886
[Journal Article] Postoperative serum concentrations of High Mortality Group Box chromosomal protein-1 correlates to the duration of SIRS and pulmonary dysfunction following gastrointestinal surgery2011
- Author(s)
  Takahata, R., Ono S, Tsujimoto H, Hiraki S, Kimura A, Kinoshita M, Miyazaki H., Saitoh D, Hase K
- Journal Title
  
  J. Surg. Res.
  
  Volume: 170
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Preoperative Toll-like receptor expression in monocytes is associated with host immunological responses following gastrointestinal surgery2011
- Author(s)
  Ono S, Tsujimoto H, Hiraki S, Kinoshita M, Hase K
- Journal Title
  
  World J. Surg
  
  Volume: 35 Pages: 365-371
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Photodynamic therapy using intra-articular photofrin for murine MRSA arthritis: biphasic light dose response for neutrophil-mediated antibacterial effect2011
- Author(s)
  Tanaka M, Kinoshita M, Yoshihara Y, Shinomiya S, Seki S, Nemoto K, Hamblin M, Morimoto Y
- Journal Title
  
  Laser Surg Med
  
  Volume: 43 Pages: 221-229
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] The immunologic outcome of enhanced function of mouse liver lymphocytes and Kupffer cells by high-fat-cholesterol diet2011
- Author(s)
  Shono S, Habu Y, Nakashima M, Sato A, Nakashima H, Miyazaki H, Kinoshita M, Tsumatori G, Shinomiya N, Seki S
- Journal Title
  
  SHOCK
  
  Volume: 36 Pages: 484-93
- NAID
  40019087222
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Intraosseous transfusion with liposome-encapsulated hemoglobin improves mouse survival after hypohemoglobinemic shock without scavenging nitric oxide2011
- Author(s)
  Shono, S., Kinoshita, M., Takase, B., Nogami, Y., Kaneda, S., Ishihara, M., Saitoh, D., Kikuchi, M. and Seki, S
- Journal Title
  
  SHOCK
  
  Volume: 35 Pages: 45-52
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Novel overlaying technique of poly L-lactic acid (PLLA) nanosheet for adhesion prophylaxis and fixation of intraperitoneal onlay polypropylene mesh in a rabbit model2011
- Author(s)
  Fujino K, Kinoshita M, Saitoh A, Yano H, Nishikawa K, Fujie T, Iwaya K, Kakihara M, Takeoka S, Saitoh D, Tanaka Y
- Journal Title
  
  Surg Endosc
  
  Volume: 25 Pages: 3428-36
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Photodynamic therapy using intra-articular Photofrin for murine MRSA arthritis : biphasic light dose response for neutrophil-mediated antibacterial effect2011
- Author(s)
  Tanaka M, Kinoshita M, Yoshihara Y, Shinomiya N, Seki S, Nemoto K, Hamblin MR, Morimoto Y
- Journal Title
  
  Lasers Surg Med
  
  Volume: 43(3) Pages: 221-229
- Data Source
  KAKENHI-PROJECT-23659628
[Journal Article] Antitumor immunity produced by the liver Kupffer cells, NK cells, NKT cells and CD8+ CD122+ T cells2011
- Author(s)
  Seki S, Nakashima H, Nakashima M, Kinoshita M
- Journal Title
  
  Clin. Dev. Immunol. 2011
  
  Volume: 2011 Pages: 864385-864385
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Augmented bacterial elimination by Kupffer cells after IL-18 pretreatment via IFN-g produced from NK cells in burn-injured mice.2011
- Author(s)
  Miyazaki, H., Kinoshita M., Ono S., Nakashima M., Hara E., Ohno H., Seki S., and Saitoh D
- Journal Title
  
  Burns
  
  Volume: 37 Pages: 1208-1215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591886
[Journal Article] Enhancement of neutrophil function by IL-18 therapy protects burn-injured mice from MRSA infection.2011
- Author(s)
  Kinoshita M, Miyazaki H., Ono S, Inatsu, A., Nakashima, H., Tsujimoto, H., Shinomiya, N., Saitoh, D., Seki, S
- Journal Title
  
  Infect Immun
  
  Volume: 79 Pages: 2670-80
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Postoperative serum concentrations of high mobility group box chromosomal protein-1 correlates to the duration of SIRS and pulmonary dysfunction following gastrointestinal surgery2011
- Author(s)
  Takahata R, Ono S, Tsujimoto H, Hiraki S, Kimura A, Kinoshita M, Miyazaki H, Saitoh D, Hase K.
- Journal Title
  
  J Surg Res
  
  Volume: 170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591886
[Journal Article] Enhancement of neutrophil function by IL-18 therapy protects burn-injured mice from MRSA infection2011
- Author(s)
  Kinoshita, M.
- Journal Title
  
  Infect.Immun.
  
  Volume: 79 Pages: 2670-2680
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Preoperative toll-like receptor expression in monocytes is associated with host immunological responses following gastrointestinal surgery.2011
- Author(s)
  Ono S, Tsujimoto H, Hiraki S, Kinoshita M, Hase K.
- Journal Title
  
  World J Surg
  
  Volume: 35 Pages: 365-371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591886
[Journal Article] Augmented bacterial elimination by Kupffer cells after IL-18 pretreatment via IFN-gamma produced from NK cells in burn-injured mice2011
- Author(s)
  Miyazaki H., Kinoshita M, Ono S, Nakashima M, Hara E, Ohno H, Seki S, Saitoh D
- Journal Title
  
  BURNS
  
  Volume: 37 Pages: 1208-1215
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Enhancement of neutrophil function by interleukin-18 therapy protects burn-injured mice from methicillin-resistant staphylococcus aureus2011
- Author(s)
  Kinoshita M, Miyazaki H, Ono S, Inatsu A, Nakashima H, Tsujimoto H, Shinomiya N, Saitoh D, Seki S.
- Journal Title
  
  Infection and Immunity
  
  Volume: 79 Pages: 2670-2680
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591886
[Journal Article] Preoperative toll-like receptor expression in monocytes is associated with host immunological responses following gastrointestinal surgery2011
- Author(s)
  Ono S, Tsujimoto H, Hiraki S, Kinoshita M, Hase K
- Journal Title
  
  World J Surg
  
  Volume: 35 Pages: 365-371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591886
[Journal Article] Enhancement of neutrophil function by interleukin-18 therapy protects burn-injured mice from methicillin-resistant staphylococcus aureus2011
- Author(s)
  Kinoshita M, Miyazaki H, Ono S, et al.
- Journal Title
  
  Infection and Immunity
  
  Volume: 79(7) Pages: 2670-2680
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591886
[Journal Article] Postoperative serum concentrations of high mobility group box chromosomal protein-1 correlates to the duration of SIRS and pulmonary dysfunction following gastrointestinal surgery2011
- Author(s)
  Takahata R, Ono S, Tsujimoto H, Kinoshita M, Miyazaki H, Saitoh D, Hase K
- Journal Title
  
  J Surg Res
  
  Volume: 170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591886
[Journal Article] Characteristic changes in heart rate variability induces during hemorrhagic shock, and effect of liposome-encapsulated hemoglobin in rats2010
- Author(s)
  Nogami, Y., Takase, B., Kinoshita, M., Shono, S., Kaneda, S., Ishihara, M., Kikuchi, M., Maehara, T
- Journal Title
  
  J Arrhythmia
  
  Volume: 26 Pages: 189-198
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Voltage gated potassium channel Kv1.3 blocker as apotential treatment for rat anti-glomerular basement membrane glomerulonephritis2010
- Author(s)
  Hyodo T, Oda T, Kikuchi Y, Higashi K, Kushiyama T, Yamamoto K, Yamada M, Suzuki S, Hokari Y, Kinoshita M, Seki S, Fujinaka F, Yamamoto T, Miura S, Kumagai H
- Journal Title
  
  Am. J. Physiol-Renal
  
  Volume: 299 Pages: 1258-1269
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Dual therapeutic action of antibiotic-loaded nanosheets for the treatment of gastrointestinal tissue defects2010
- Author(s)
  Fujie, T., Saito, A., Kinoshita, M., Ohtsubo, S., Saitoh, D., and Takeoka, S
- Journal Title
  
  Biomaterials
  
  Volume: 31 Pages: 6269-6278
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Sealing effect of a polysaccharide nanosheet for murine cecal puncture2010
- Author(s)
  Fujie, T., Kinoshita, M., Shono, S., Saito, A., Okamura, Y., Saitoh, D., Takeoka, S
- Journal Title
  
  Surgery
  
  Volume: 148 Pages: 48-58
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Immunosuppression in the livers of mice with obstructive jaundice participates in their susceptibility to bacterial infection and tumor metastasis2010
- Author(s)
  Kawarabayashi, N., Seki, S., Hatsuse, K., Kinoshita, M., Takigawa, T., Tsujimoto, H., Kawabata, T., Nakashima, H., Shono, S., and Mochizuki, H
- Journal Title
  
  SHOCK
  
  Volume: 33 Pages: 500-506
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] The effect of ketamine anesthesia on the immune function of mice with postoperative septicemia2010
- Author(s)
  Takahashi, T., Kinoshita, M., Shono, S., Habu, Y., Ogura, T., Seki S., Kazama, T
- Journal Title
  
  Anesth Analg
  
  Volume: 111 Pages: 1051-1058
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Cardiac dysfunction induced by experimental myocardial infarction impairs the host defense response to bacterial infection in mice due to reduced phagocytosis of Kupffer cells2010
- Author(s)
  Nogami, Y., Kinoshita, M., Takase, B., Inatsu, A., Ishihara, M., Seki, S., and Maehara, T
- Journal Title
  
  J. Thorac. Cardiovasc. Surg.
  
  Volume: 140 Pages: 624-632
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Influence of Intraarticular Neutrophils on the Effects of Photodynamic Therapy for Murine MRSA Arthritis2010
- Author(s)
  Tanaka, M., Kinoshita, M., Yoshihara, Y., Shinomiya, N., Seki, S., Nemoto, K., Morimoto, Y
- Journal Title
  
  Photochem. Photobiol
  
  Volume: 86 Pages: 403-409
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Characteriation of two F4/80-positive Kupffer cell subsets by their function and phenotype in mice.2010
- Author(s)
  Kinoshita, M.
- Journal Title
  
  J.Hepatol.
  
  Volume: 53 Pages: 903-910
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Characteriation of two F4/80-positive Kupffer cell subsets by their function and phenotype in mice2010
- Author(s)
  Kinoshita, M., Uchida, T., Sato, A., Nakashima, M., Nakashima H., Shono S., Habu, Y., Miyazaki, H., Hiroi, S., Seki, S
- Journal Title
  
  J. Hepatol
  
  Volume: 53 Pages: 903-910
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Pretreatment with ascorbic acid prevents lethal gastrointestinal syndrome in mice receiving a massive amount of radiation2010
- Author(s)
  Yamamoto, T., Kinoshita, M., Shinomiya, N., Hiroi, S., Sugasawa, H., Matsushita, Y., Majima, T., Saitoh, D., Seki, S
- Journal Title
  
  J. Radiat. Res.
  
  Volume: 51 Pages: 145-156
- NAID
  10025914571
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Linezolid and vancomycin decrease the therapeutic effect of methylene blue-photodynamic therapy in a mouse model of MRSA bacterial arthritis
- Author(s)
  Tanaka M, Mroz P, Dai T, Huang L, Morimoto Y, Kinoshita M, Yoshihara Y, Shinomiya N, Seki S, Nemoto K, Hamblin M
- Journal Title
  
  Photochem. Photobiol
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] The effect of synthetic C-reactive protein on the in vitro immune response of human PBMCs stimulated with bacterial reagents
- Author(s)
  Sato A, Nakashima H, Kinoshita M, Nakashima M, Ogawa Y, Shono S, Ikarashi M, Seki S
- Journal Title
  
  Inflammation
- NAID
  130004638709
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Tissue Engineering of the Stomach
- Author(s)
  Maemura T, Shin M, Kinoshita M
- Journal Title
  
  J. Surg. Res.
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Effective control of massive venous bleeding by "multi-overlapping therapy" using polysaccharide nanosheets in rabbit inferior vena cava injury model
- Author(s)
  Hagisawa K, Saito A, Kinoshita M, Fujie T, Otani N, Shono S, Park YK, Takeoka S
- Journal Title
  
  J. Vasc. Surg.
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] Pioglitazone reinforces liver innate immunity against bacterial infection in aged mice.2020
- Author(s)
  Nakashima Masahiro, Kinoshita Manabu, Nakashima Hiroyuki, Seki Shuhji.
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-17K08611
[Presentation] 重症病態におけるミトコンドリアの代謝制御と免疫系への作用2019
- Author(s)
  宮崎裕美、木下　学、山本　順寛、戸村　哲、関　修司、齋藤　大蔵
- Organizer
  第33回日本外傷学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17K11602
[Presentation] The effect of LPS preconditioning on the lethal malaria infection2019
- Author(s)
  Takeshi Ono, Manabu Kinoshita, Yoko Yamaguchi, Yasushi Miyahira
- Organizer
  The 48th Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-19K07493
[Presentation] Coenzyme Q10 improves susceptibility to methicillin-resistant Staphylococcus aureus bloodstream infection in extensive burned mice by modulating intestinal immunity2019
- Author(s)
  Miyazaki Hiromi, Kinoshita Manabu, Tomura Satoshi, Seki Shuhji, Saitoh Daizoh
- Organizer
  第48回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17K11602
[Presentation] 人工赤血球、人工血小板開発の最前線、外傷性大量出血への挑戦2018
- Author(s)
  木下　学
- Organizer
  埼玉県急性期治療フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-18H02907
[Presentation] Intraosseous Transfusion With Hemoglobin Vesicles for Severe Hemorrhagic Shock Rabbits2018
- Author(s)
  Hagisawa Kohsuke, Kinoshita Manabu, Sakai Hiromi
- Organizer
  American Heart Association 2018 Resuscitation Science Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11435
[Presentation] LPS プレコンディショニングによる肝マクロファージの殺菌能増強とグラム陰性陽性両敗血症への救命効果2018
- Author(s)
  木下　学, 宮﨑　裕美, 中島　正裕, 中島　弘幸 , 石切山　拓也, 加藤　章一郎, 四ノ宮　成祥, 関　修司
- Organizer
  日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] Medical countermeasure for post-traumatic immunosuppression and susceptibility of infection2018
- Author(s)
  Kinoshita m
- Organizer
  Japan-US Technical information exchange forum on blast injury
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02907
[Presentation] LPS preconditioning potently enhances liver antitumor activity in mice despite marked suppression of inflammatory response2018
- Author(s)
  Kinoshita M, Nishikawa M, Nakashima H, Nakashima M, Ishikiriyama T, Kato S, Seki S
- Organizer
  日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-18H02907
[Presentation] LPS preconditioning potently enhances liver antitumor activity in mice despite marked suppression of inflammatory response2018
- Author(s)
  Manabu Kinoshita, Hiroyuki Nakashima, Masahiro Nakashima, Takuya Ishikiriyama, Shoichiro Kato, Hiromi Miyazaki
- Organizer
  2018年度　日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] Development of hemostatic nanoparticles (platelet substitutes) for the resuscitation of trauma hemorrhage2018
- Author(s)
  Kinoshita M, Hagisawa K
- Organizer
  Non-conventionaal Threat Asia Pacific
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02907
[Presentation] The efficacy of platelet substitutes, H12(ADP)liposomes, for the treatment of hemorrhagic shock caused by mesenteric injury in rabbits with trauma-induced coagulopathy2018
- Author(s)
  Kinoshita M, Hagisawa K
- Organizer
  Military Health Research Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02907
[Presentation] 核内受容体活性化を介した自然免疫調節による重症熱傷後の敗血症対策2018
- Author(s)
  宮崎裕美、木下学、瀬野宗一郎、関根康雅、戸村哲、関修司、齋藤大蔵
- Organizer
  第46回日本救急医学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17K11602
[Presentation] Liver X Receptor activation exerts the different effects on the function of liver resident Kupffer cells and recruited macrophages2018
- Author(s)
  Takuya Ishikiriyama, Hiroyuki Nakashima, Shoichiro Kato, Kori Endo-Umeda, Masahiro Nakashima, Manabu Kinoshita, Makoto Makishima, Shuhji Seki
- Organizer
  2018年度　日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] Pioglitazone prevents sepsis in old mice by enhancing liver innate immunity2018
- Author(s)
  Masahiro Nakashima, Hiroyuki Nakashima, Manabu Kinoshita, Takuya Ishikiriyama, Shoichiro Kato, Shuhji Seki
- Organizer
  2018年度　日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] LPS preconditioningによる抗腫瘍活性増強効果と外科周術期管理での有用性2018
- Author(s)
  木下学、西川誠、中島正裕、中島弘幸、関修司
- Organizer
  日本エンドトキシン自然免疫研究会
- Data Source
  KAKENHI-PROJECT-18H02907
[Presentation] シンポジウム：自然免疫応答の制御による重度侵襲後の敗血症対策2018
- Author(s)
  宮崎裕美、木下学、戸村哲、関修司、齋藤大蔵
- Organizer
  第33回日本Shock学会総会
- Data Source
  KAKENHI-PROJECT-17K11602
[Presentation] LPS tolerance を用いたグラム陰性陽性両敗血症に対する救命治療戦略の可能性2017
- Author(s)
  木下　学, 宮﨑　裕美, 中島　正裕, 中島　弘幸 , 萩沢　康介, 関　修司
- Organizer
  日本Shock 学会総会
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] Combination Therapy with Red Blood Cell Substitute and Platelet Substitute Effectively Rescues Rabbits from Massive Hemorrhage Caused by Thrombocytopenic Coagulopathy.2017
- Author(s)
  Kinoshita Manabu, Hagisawa Kohsuke, Sakai Hiromi, Takeoka Shinji, Saitoh Daizoh, Shinomiya Nariyoshi, Seki Shuhji
- Organizer
  Military Health System Research Symposium 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11435
[Presentation] Medical countermeasures using LPS tolerance to address lethal toxic shock and fatal bacterial sepsis2017
- Author(s)
  Manabu Kinoshita, Nariyoshi Shinomiya, Hiromi Miyazaki, Hiroyuki Nakashima , Masahiro Nakashima, ShujiSeki
- Organizer
  Chemical and Biological Defense Science & Technology Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] Complete Blood Substitute for Massive Transfusion in Thrombocytopenic and Hemorrhagic Shock Rabbits.2017
- Author(s)
  Hagisawa Kohsuke, Kinoshita Manabu
- Organizer
  American Heart Association 2017 Resuscitation Science Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11435
[Presentation] LPS tolerance recruits CD11b+ macrophages to the liver with enhanced bactericidal activity and low TNF-releasing capability, resulting in drastic resistance to lethal septicemia2017
- Author(s)
  Kinoshita Manabu, Miyazaki Hiromi, Nakashima Masahiro, Nakashima Hiroyuki, Ishikiriyama Takuya, Kato Shoichiro, Shinomiya Nariyoshi, Seki Shuhji
- Organizer
  日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] In vivo LPS tolerance recruits CD11b+ macrophages to the liver with enhanced bactericidal activity and low TNFreleasing capability, resulting in drastic resistance to lethal septicemia2017
- Author(s)
  Kinoshita Manabu, Miyazaki Hiromi, Nakashima Hiroyuki, Nakashima Masahiro, Nishikawa Makoto, Hagisawa Kohsuke, Seki Shuhji
- Organizer
  2017 Shock Society： Shock 47
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] パネルディスカッション侵襲を制御する：熱傷後の敗血症に対する自然免疫応答制御の有効性2017
- Author(s)
  宮崎裕美、木下学、関根康雅、瀬野宗一郎、戸村哲、関修司、齋藤大蔵
- Organizer
  第45回日本救急医学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17K11602
[Presentation] Hemoglobin Vesicles and Fibrinogen gamma-chain peptide-coated, Adenosine Diphosphate-encapsulated Liposomes Rescue Rabbits from Hemorrhagic Shock with Trauma-Induced Coagulopathy.2017
- Author(s)
  Hagisawa Kohsuke, Kinoshita Manabu
- Organizer
  2017 Shock Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11435
[Presentation] Basic fibroblast growth factor-loaded PLGA nanosheet promotes wound healing of refractory skin lesions(増殖因子担持ナノシートの難治性皮膚潰瘍に対する被覆治療効果)2017
- Author(s)
  Manabu Kinoshita,Nariyoshi Shinomiya,Aoki Shimpo,Tomoharu Kiyosawa,ShujiSeki
- Organizer
  Chemical and Biological Defense Science & Technology Conference
- Data Source
  KAKENHI-PROJECT-15K10961
[Presentation] Liver sinusoidal endothelial cells and resident Kupffer cells are involved in cholesterol metabolism in mice2017
- Author(s)
  Nakashima Hiroyuki, Kato Shoichiro, Ishikiriyama Takuya, Nakashima Masahiro, Kinoshita Manabu, Seki Shuhji
- Organizer
  日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] Coenzyme Q10 supplementation protects against methicillin-resistant Staphylococcus aureus infection in burn-injured mice2017
- Author(s)
  宮崎裕美、木下学、戸村哲、瀬野宗一郎、関修司、齋藤大蔵
- Organizer
  第46回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17K11602
[Presentation] Excessive activation of liver natural killer cells and phenotypic alteration and dysfunction of Kupffer cells in diabetic mice with sepsis, and reversal by insulin treatment2016
- Author(s)
  Kinoshita,M. Miyazaki, H. Nakashima, H. Nakashima, M. Seki, S.
- Organizer
  The 45th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  Okinawa Convention Center
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] Activation of PPAR gamma protects against postburn infection by regulating innate immune response2016
- Author(s)
  Miyazaki H, Kinoshita M, Nakashima H, Nakashima M, Tomura S, Seno S, Seki S, Saitoh D.
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県・宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-26462773
[Presentation] Activation of PPAR gamma protects against postburn infection by regulating innate immune response2016
- Author(s)
  Miyazaki, H. Kinoshita,M. Nakashima, H. Nakashima, M. Seki, S.
- Organizer
  The 45th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  Okinawa Convention Center
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] 大量出血性凝固障害をH12-ADP-liposomeで制御する　－最適の病院前治療に向けて－2016
- Author(s)
  萩沢康介、木下学、多喜川真人、武岡真司、鈴木英紀、宮崎裕美、斎藤大蔵
- Organizer
  第23回日本血液代替物学会年次大会
- Place of Presentation
  東京
- Year and Date
  2016-11-24
- Data Source
  KAKENHI-PROJECT-16K11435
[Presentation] 核内受容体活性化を介した重症熱傷後の細菌感染症対策2016
- Author(s)
  宮﨑裕美, 木下学, 瀬野宗一郎, 戸村哲, 関修司, 齋藤大蔵
- Organizer
  第44回日本救急医学会総会・学術集会
- Place of Presentation
  グランドプリンスホテル新高輪（東京）
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-26462773
[Presentation] 腹部救急疾患における汚染手術での術後癒着軽減への挑戦ーPLAナノシートの癒着防止効果の特徴ー2016
- Author(s)
  木下学、檜顕成、齊藤晃広、内田広夫、武岡真司、関修司
- Organizer
  第52回日本腹部救急医学会総会
- Place of Presentation
  東京
- Year and Date
  2016-03-03
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] 転写因子活性化による重症熱傷後感染対策2016
- Author(s)
  宮崎裕美、木下学、関修司、戸村哲、齊藤大蔵
- Organizer
  第24回日本熱傷学会関東地方会
- Place of Presentation
  東京
- Year and Date
  2016-02-20
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] Pioglitazone restores phagocytic activity and ameliorates postburn infection in mice2016
- Author(s)
  Miyazaki H, Kinoshita M, Nakashima H, Nakashima M, Seno S, Sekine Y, Tomura S, Seki S, Saitoh D.
- Organizer
  The 8th Congress of the International Federation of Shock Societies
- Place of Presentation
  東京ドームホテル（東京）
- Year and Date
  2016-10-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462773
[Presentation] Resuscitation by transfusion with Hemoglobin Vesicles in Trauma Hemorrhagic Shock / Coagulopathy Rabbits.2016
- Author(s)
  Hagisawa K, Kinoshita M
- Organizer
  American Heart Association 2016 Resuscitation Science Symposium
- Place of Presentation
  New Orleans, LA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11435
[Presentation] Activation and increase of radio-sensitive CD11b+ recruited Kupffer cells/macrophages in diet-induced steatohepatitis in FGF5 deficient mice2016
- Author(s)
  Nakashima, H. Nakashima, M. Kinoshita,M. Seki, S.
- Organizer
  The 45th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  Okinawa Convention Center
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] シンポジウム:培養皮膚とアログラフトを用いた重症熱傷ハイブリッド治療「マイクロスキン技術を応用した熱傷治療の有用性」2016
- Author(s)
  宮崎裕美, 木下学, 川内聡子, 佐藤俊一, 齋藤大蔵
- Organizer
  第42回日本熱傷学会総会・学術集会
- Place of Presentation
  シェラトン・グランデ・トーキョーベイホテル（千葉県・浦安市）
- Year and Date
  2016-06-02
- Data Source
  KAKENHI-PROJECT-25462844
[Presentation] PPAR-γ agonist protects burn-injured mice from bacterial infection2016
- Author(s)
  Miyazaki H, Kinoshita M, Seno S, Tomura S, Seki S, Saitoh D.
- Organizer
  The 18th Congress of International Society for Burn Injuries
- Place of Presentation
  Miami (USA)
- Year and Date
  2016-08-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462844
[Presentation] Activation of PPAR gamma protects against postburn infection by regulating innate immune response2016
- Author(s)
  Miyazaki H, Kinoshita M, Nakashima H, Nakashima M, Tomura S, Seno S, Seki S, Saitoh D.
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県・宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-25462844
[Presentation] Prehospital transfusion with H12-ADP-liposome instead of conventional Platelet concentrate.2016
- Author(s)
  Hagisawa K, Takikawa M, Kinoshita M
- Organizer
  39th Annual Conference on Shock
- Place of Presentation
  Austin, TX
- Year and Date
  2016-06-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11435
[Presentation] 加齢に伴う自然免疫機構の低下とピオグリタゾン投与による増強2016
- Author(s)
  Nakashima, H.　Kinoshita, M.　Seki, S.
- Organizer
  第89回日本細菌学会総会
- Place of Presentation
  大阪　日本
- Year and Date
  2016-03-23
- Data Source
  KAKENHI-PROJECT-25460508
[Presentation] 放射線防護剤としての新規安定型ビタミンＣ製剤の開発2015
- Author(s)
  木下学
- Organizer
  日本集団災害医学会
- Place of Presentation
  東京
- Year and Date
  2015-02-17
- Data Source
  KAKENHI-PROJECT-26670569
[Presentation] Burn-evoked reactive oxygen species after injury are crucial to restore the neutrophil function in mice2015
- Author(s)
  Miyazaki H, Kinoshita M, Seki S, Saitoh D.
- Organizer
  15th International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants
- Place of Presentation
  Paris, France
- Year and Date
  2015-06-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462773
[Presentation] Treatment with fibrinogen gamma-chain peptide coated, ADP-encapsulated liposomes as a systhetic platelet substitute against active liver bleeding in rabbits with acute thrombocytopenia2015
- Author(s)
  Kinoshita M
- Organizer
  Military Health System Research Symposium 2015
- Place of Presentation
  Maiami FL
- Year and Date
  2015-08-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] 外科侵襲後の複合免疫不全とその対策2015
- Author(s)
  木下学
- Organizer
  第30回日本ショック学会総会
- Place of Presentation
  東京
- Year and Date
  2015-05-22
- Invited
- Data Source
  KAKENHI-PROJECT-26670569
[Presentation] Burn evoked ROS immediately after injury are crucial to rescue the neutrophil function against post-burn infection in mice2015
- Author(s)
  Kinoshita M, Miyazaki H, Ono S, Hagisawa K, Seki S, Saitoh D.
- Organizer
  38th Annual congress on Shock
- Place of Presentation
  Denver, USA
- Year and Date
  2015-06-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462773
[Presentation] Mouse CD11b+Kupffer cells recruited from bone marrow accelerate liver regeneration after partial hepatectomy2015
- Author(s)
  Nakashima, H.　Kinoshita, M.　Seki, S.
- Organizer
  Liver meeting 2015 AASLD
- Place of Presentation
  San Francisco, USA
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460508
[Presentation] Bio-preparedness in Japan2015
- Author(s)
  Kinoshita M, Saito T
- Organizer
  ASEAN Biopreparedness Meeting and Exercise
- Place of Presentation
  Manila
- Year and Date
  2015-08-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] bFGF担持ナノシートの開発と創傷治癒への応用2015
- Author(s)
  青木伸峰, 清澤智晴, 木下学, 齋藤大蔵, 藤井麻央, 藤枝俊宣, 西脇圭亮, 武岡真司
- Organizer
  第24回日本形成外科学会基礎学術集会
- Place of Presentation
  盛岡
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25462844
[Presentation] Decreased innate immunity in aged mice and improvemet by pioglitazone pretreatment2015
- Author(s)
  Nakashima, H.　Kinoshita, M.　Seki, S.
- Organizer
  第44回日本免疫学会
- Place of Presentation
  札幌　日本
- Year and Date
  2015-12-19
- Data Source
  KAKENHI-PROJECT-25460508
[Presentation] レーザー衝撃波による肺出血に対するH12-ADP-liposomeの救命効果2015
- Author(s)
  萩沢康介、木下学、宮脇博基、佐藤俊一、鈴木英紀ら
- Organizer
  第22回日本血液代替物学会シンポジウム・人工血小板の新しい展開に向けて
- Place of Presentation
  熊本
- Year and Date
  2015-10-23
- Data Source
  KAKENHI-PROJECT-25462843
[Presentation] Fibrinogen gamma-chain peptide-coated, ADP-encapsulated liposomes rescue mice from lethal blast lung injury2015
- Author(s)
  Hagisawa K, Kinoshita M, Miyawaki H, Miyazaki H, Nishida Y.
- Organizer
  38th Annual congress on Shock
- Place of Presentation
  Denver CO
- Year and Date
  2015-06-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] Biosecurity concern related to recent development of life science technology2015
- Author(s)
  Shinomiya N, Kinoshita M, Seki S, Minehata M, Dando M
- Organizer
  2015 Chemical Biological Defense & Technology Conference
- Place of Presentation
  St Louis
- Year and Date
  2015-05-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] 小児腹膜炎における汚染手術での術後癒着軽減への挑戦～ PLAナノシートの癒着防止効果の特徴～2015
- Author(s)
  檜顕成, 齋藤晃広, 木下学, 谷水長丸, 宮崎裕美, 北川大輝, 小岩井和樹, 青笹季文,山崎民大, 守屋智之, 野呂拓史, 小野聡, 齋藤大蔵, 武岡真司, 長谷和生, 山本順司
- Organizer
  第115回日本外科学会定期学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-25462844
[Presentation] 抗菌性を有した機能性ナノシートによる熱傷治療2015
- Author(s)
  宮崎裕美, 木下学, 藤枝俊宣, 武岡真司, 齋藤大蔵
- Organizer
  第41回日本熱傷学会総会・学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-06-18
- Data Source
  KAKENHI-PROJECT-25462844
[Presentation] 家兎での血小板減少時の肝損傷に対する人工血小板による止血救命2015
- Author(s)
  木下学、萩沢康介、西川可穂子、柳川錬平、関修司
- Organizer
  第51回日本腹部救急医学会
- Place of Presentation
  京都
- Year and Date
  2015-03-06
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] Burn-evoked ROS immediately after injury are crucial to rescue the neutrophil function against post-burn infection in mice2015
- Author(s)
  Kinoshita M, Miyazaki H, Ono S, Hagisawa K, Saitoh D, Seki S,
- Organizer
  38th Annual congress on Shock
- Place of Presentation
  Denver CO
- Year and Date
  2015-06-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] 救急医療における人工血小板の必要性と展望2015
- Author(s)
  木下学、萩沢康介、朝比奈はるか、田中良弘、齊藤大蔵、高瀬凡平
- Organizer
  第22回日本血液代替物学会
- Place of Presentation
  熊本
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] Peroxisome proliferator activated receptor-gamma agonist improves survival in a murine model of postburn infection by modulating the macrophage function2015
- Author(s)
  Miyazaki H, Kinoshita M, Hagisawa K, Seki S, Saitoh D.
- Organizer
  38th Annual congress on Shock
- Place of Presentation
  Denver CO
- Year and Date
  2015-06-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] 銀含有機能性ナノシートの熱傷創に対する有用性評価2015
- Author(s)
  宮崎裕美、伊藤佳祐、木下学、藤枝俊宣、武岡真司、齋藤大蔵
- Organizer
  第23回日本熱傷学会関東地方会
- Place of Presentation
  日本医科大学（東京）
- Year and Date
  2015-01-31
- Data Source
  KAKENHI-PROJECT-25462844
[Presentation] Resuscitation by transfusion with hemoglobin vesicle in trauma hemorrhagic shock/ coagulopathy rabbits.2015
- Author(s)
  Hagisawa k, Kinoshita, M Sakai H, Nishida Y.
- Organizer
  American Heart Association 2015 Resuscitation science symposium
- Place of Presentation
  Orlando FL
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] Fibroblast growth factor 5欠損マウスは高脂肪食によりCD11b陽性Kupffer細胞を活性化させ脂肪性肝炎を発症する2015
- Author(s)
  Nakashima, H.　Kinoshita, M.　Seki, S.
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  熊本　日本
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25460508
[Presentation] 凝固障害を伴う出血性ショックに対して人工赤血球による蘇生の試み2015
- Author(s)
  朝比奈はるか、萩沢康介、木下学、齊藤大蔵
- Organizer
  第22回日本血液代替物学会
- Place of Presentation
  熊本
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] 衝撃波による致死的肺出血マウスに対する人工血小板（H12-ADP-liposome）の救命効果2014
- Author(s)
  萩沢康介、木下学、宮脇博基ら
- Organizer
  第29回日本Shock学会
- Place of Presentation
  松山市
- Data Source
  KAKENHI-PROJECT-25462843
[Presentation] 外科侵襲後の免疫応答の病態解析とその対策に関する研究2014
- Author(s)
  小野聡, 辻本広紀, 平木修一, 木下学,
- Organizer
  第113回日本外科学会定期学術集会シンポジウム
- Place of Presentation
  京都
- Year and Date
  2014-04-03
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] 衝撃波による致死的肺出血マウスに対する人工血小板（H12-ADP-liposome）の救命効果2014
- Author(s)
  2.萩沢康介、木下学、宮脇博基、佐藤俊一、鈴木英紀、土井麻美、武岡真司、小野聡、斎藤大蔵、西田育弘
- Organizer
  第29回日本ショック学会　学会長賞受賞
- Place of Presentation
  愛媛県松山市
- Year and Date
  2014-05-17
- Data Source
  KAKENHI-PROJECT-25462843
[Presentation] 超薄膜ナノシートを応用した熱傷治療2014
- Author(s)
  宮崎裕美, 木下学, 小野聡
- Organizer
  第40回日本熱傷学会総会
- Place of Presentation
  さいたま
- Year and Date
  2014-06-04
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] 人工赤血球や人工血小板などの血液代替物の開発とその将来展望2014
- Author(s)
  木下学、萩沢康介、西川可穂子、柳川錬平、小野　聡、齋藤大蔵、高瀬凡平、酒井宏水、半田誠、武岡真司、関修司
- Organizer
  第114回日本外科学会定期学術集会　(パネルデスカッション1-3)
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] 人工赤血球や人工血小板などの血液代替物の開発とその将来展望2014
- Author(s)
  木下学, 萩沢康介, 西川可穂子
- Organizer
  第113回日本外科学会定期学術集会パネルディスカッション
- Place of Presentation
  京都
- Year and Date
  2014-04-03
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] Nobel therapeutic strategy against burn-wound bacterial infection using antibiotic-loaded nanosheet.2014
- Author(s)
  Kinoshita M, Saito A, Miyazaki H, Fujie T, Takeoka S, Shinomiya N, Seki S
- Organizer
  第86回日本細菌学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] 人工赤血球製剤による救命救急の可能性2014
- Author(s)
  木下学, 高瀬凡平, 田中良弘
- Organizer
  第62回日本輸血・細胞治療学会
- Place of Presentation
  奈良
- Year and Date
  2014-05-17
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] Glucocorticoid receptor-dependent immunomodurately effect of ursodeoxycholic acid on liver lymphocytes in mice.2013
- Author(s)
  Kinoshita M, Miyazaki H, Nakashima H, Ikarashi M, Seki S
- Organizer
  15th International congress of Immunology
- Place of Presentation
  Milan
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] Distinct development and function of resident and recruited liver Kupffer cells / macrophages2013
- Author(s)
  Masami Ikarashi, Hiroyuki Nakashima, Manabu Kinoshita, Shuhji Seki
- Organizer
  日本免疫学会
- Place of Presentation
  千葉　幕張
- Data Source
  KAKENHI-PROJECT-25460508
[Presentation] 糖尿病マウスでの創部感染増悪への好中球機能不全の関与トインスリン治療2013
- Author(s)
  木下学、矢野秀和、小野聡、浜田耕司、田中祐司、関修司
- Organizer
  第50回日本外科代謝栄養学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] 重度外傷や熱傷に続発する複合免疫不全とその対策.2013
- Author(s)
  木下学
- Organizer
  第90回日本生理学会（シンポジウム３重度外傷と免疫・生理学―基礎から臨床まで―）
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] (シンポジウム）外科侵襲後の免疫応答の病態解析とその対策に関する研究2013
- Author(s)
  小野　聡、辻本広紀、平木修一、高畑りさ、木村暁史、久保　徹、松本佑介、吉田一路、堀口寛之、野村信介、青笹季文、木下　学、山本順司、長谷和生、齋藤大蔵
- Organizer
  第113回日本外科学会定期学術集会
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-23591886
[Presentation] Activation of CD11b+ Kupffer cells/macrophages as a common cause for exacerbation of TNF/ Fas-ligand-dependent hepatitis in hypercholesterolemic mice2013
- Author(s)
  Hiroyuki Nakashima, Manabu Kinoshita, Shuhji Seki
- Organizer
  国際免疫学会議
- Place of Presentation
  イタリア　ミラノ
- Data Source
  KAKENHI-PROJECT-25460508
[Presentation] Glucocorticoid receptor-dependent immunomodulatory effect of ursodeoxycholic acid and on liver lymphocytes in mice2013
- Author(s)
  Manabu Kinoshita, Hiroyuki Nakashima, Shuhji Seki
- Organizer
  日本免疫学会
- Place of Presentation
  千葉　幕張
- Data Source
  KAKENHI-PROJECT-25460508
[Presentation] CD11b+ Kupffer cells/macrophages accelarates liver regeneration after partial hepatectomy2013
- Author(s)
  Kiyoshi Nishiyama, Hiroyuki Nakashima, Manabu Kinoshita, Shuhji Seki
- Organizer
  日本免疫学会
- Place of Presentation
  千葉　幕張
- Data Source
  KAKENHI-PROJECT-25460508
[Presentation] 熱傷などの重度外科侵襲に続発する複合免疫不全病態とIL-18による免疫賦活.2013
- Author(s)
  木下学、宮崎裕美、小野聡、関修司
- Organizer
  第26回日本外科感染症学会総会(パネルデスカッション)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] Resveratrol increases CD68 positive Kupffer cells with phagocytic activity to lipid droplets and ameliorates high-fat diet induced fatty liver in mice2013
- Author(s)
  Nishikawa K, Kinoshita M, Iwaya K, Sakamoto T, Seki S.
- Organizer
  第42回日本免疫学会総会
- Place of Presentation
  幕張（千葉）
- Data Source
  KAKENHI-PROJECT-25504021
[Presentation] 大量出血後の血小板減少状態下での肝外傷出血に対するH12(ADP)リポソーム投与の止血救命効果.2013
- Author(s)
  萩沢康介、木下学、西川可穂子、柳川錬平、土井麻実、武岡真司、齋藤大蔵、関修司、西田育弘、半田誠
- Organizer
  日本血栓止血学会第85回学術集会
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] 外科侵襲後の免疫応答の病態解析とその対策に関する研究2013
- Author(s)
  小野聡、辻本広紀、木下学、長谷和生、齋藤大蔵, 他
- Organizer
  第113回日本外科学会定期学術集会
- Place of Presentation
  福岡(シンポジウム)
- Data Source
  KAKENHI-PROJECT-23591886
[Presentation] 出血性ショック心臓における致死性不整脈発生機序及び人工酸素運搬体による治療効果に関する検討.2013
- Author(s)
  高瀬凡平、東村悠子、田中良弘、木下学
- Organizer
  第20回日本血液代替物学会（シンポジウム2-5）
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] 人工血小板H12(ADP)liposomeの止血能評価（臓器損傷後投与による検討）2013
- Author(s)
  土井麻実、木下学、萩沢康介、西川可穂子、柳川錬平、半田誠、池田康夫、武岡真司
- Organizer
  第20回日本血液代替物学会（シンポジウム2-5）
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] H12-ADP-liposomeの新たな適応: 衝撃波による肺出血マウスに対するH12-ADP-liposomeの救命効果2013
- Author(s)
  萩沢康介、木下学、宮脇博基ら
- Organizer
  第20回日本血液代替物学会　シンポジウム人工血小板／H12-(ADP)リポソームの前臨床
- Place of Presentation
  奈良市
- Data Source
  KAKENHI-PROJECT-25462843
[Presentation] The Predictive Value of Endotoxin Activity Assay for The Incidence of Postoperative Infectious Complications Following Elective Gastrointestinal Surgery2013
- Author(s)
  Ono S, Miyazaki H, Tsujimoto H, Kinoshita M, Hase K, Saitoh D, et al.
- Organizer
  Thirty-sixth Annual Conference on Shock
- Place of Presentation
  San Diego, California, USA
- Data Source
  KAKENHI-PROJECT-23591886
[Presentation] Treatment with Fibrinogen γ-chain Peptide-coated, Adenosine Diphosphate-encapsulated Liposomes as An Infusible Haemostatic Agent for Dilutional Coagulopathy.2013
- Author(s)
  Hagisawa K, Kinoshita M, Nishikawa K, Nishida Y
- Organizer
  American Heart Association 2013. Resuscitation Science Symposium
- Place of Presentation
  Dallas
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] H12(ADP)liposomeの新たな適応：衝撃波による肺出血に対するH12(ADP)liposomeの救命効果.2013
- Author(s)
  萩沢康介、木下学、宮脇博基、佐藤俊一、鈴木英紀、土井麻実、武岡真司、齋藤大蔵、西田育弘
- Organizer
  第20回日本血液代替物学会（シンポジウム2-5）
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] 血小板代替物H12(ADP)liposome開発の必要性―大規模震災時への対策の１つとして―.2012
- Author(s)
  木下学
- Organizer
  第19回日本血液代替物学会（シンポジウム2-4）
- Place of Presentation
  旭川
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] 外科侵襲後の生体反応における免疫不全の病態解析とその対策に関する検討2012
- Author(s)
  小野聡、辻本広紀、宮崎裕美、木下学、長谷和生、齋藤大蔵, 他
- Organizer
  第112回日本外科学会定期学術集会
- Place of Presentation
  千葉(パネルディスカッション)
- Data Source
  KAKENHI-PROJECT-23591886
[Presentation] Insulin treatment directly restores neutrophil phagocytosis and bactericidal activity in diabetic mice, thereby improving surgical site infection with Staphylococcus aureus.2012
- Author(s)
  Kinoshita, M
- Organizer
  第41回日本免疫学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] 合成CRPのヒト末梢血単核球に対する炎症性サイトカイン産生抑制効果と抗腫瘍活性増強効果.2012
- Author(s)
  木下学
- Organizer
  第49回日本外科代謝・栄養学会（シンポジウム1）
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] 超極薄膜ナノシートの外科手術用創傷被覆剤としての応用.2012
- Author(s)
  木下学
- Organizer
  第112回日本外科学会定期学術集会（シンポジウム）
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] Antibiotic-loaded nanosheet is an effective therapeutic tool against infection in burn-injured skin lesions.2012
- Author(s)
  Kinoshita, M
- Organizer
  5th Annual CBRNe Convergence
- Place of Presentation
  Norfolk VA
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] 外科侵襲後の複合免疫不全による易感染病態とIL-18を用いた免疫賦活化対策.2012
- Author(s)
  木下学
- Organizer
  第27回日本shock学会総会　(シンポジウムII-5)
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] Enhancement of neutrophil function by IL-18 therapy protects burn-injured mice from MRSA.2012
- Author(s)
  Kinoshita, M
- Organizer
  35th Annual Conference on Shock
- Place of Presentation
  Miami FL
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] （パネルディスカッション）外科侵襲後の生体反応における免疫不全の病態解析とその対策に関する検討2012
- Author(s)
  小野　聡、辻本広紀、平木修一、高畑りさ、木村暁史、矢口義久、熊野　勲、松本佑介、吉田一路、堀口寛之、宮崎裕美、木下　学、山本順司、長谷和生、齋藤大蔵
- Organizer
  第112回日本外科学会定期学術集会（千葉）
- Place of Presentation
  幕張メッセ
- Data Source
  KAKENHI-PROJECT-23591886
[Presentation] 重症敗血症の病態解析における多項目サイトカイン同時測定の意義2011
- Author(s)
  小野　聡、辻本広紀、平木修一、高畑りさ、木村暁史、矢口義久、松本佑介、吉田一路、野村信介、木下　学、宮庄拓、山本順司、長谷和生、齋藤大蔵
- Organizer
  第111回日本外科学会定期学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591886
[Presentation] Pioglitazone Improves Mouse Survival After Post-Burn Bacterial Infection Via Restoration of Kupffer Cell Function2011
- Author(s)
  Miyazaki H, Kinoshita M, Ono S, Seki S, Saitoh D
- Organizer
  18th Annual Meeting of Society for Free Radical Biology and Medicine
- Place of Presentation
  Atlanta, USA
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] Interleukin-18 treatment following burn injury activates Kupffer cell phagocytosis in mice2010
- Author(s)
  Miyazaki H, Kinoshita M, Ono S, Hara E, Takagi T, Seki S, Saitoh D
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  Kobe Japan
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] Interleukin-18 therapy enhances Kupffer cell-mediated bacterial elimination in post-burn infection models via the activation of NK cell function2010
- Author(s)
  Kinoshita M, Shinomiya N, Miyazaki H, Ono S, Saitoh D, Seki S
- Organizer
  Chemical and Biological Defense Science and Technology (CBD S&T) 2010
- Place of Presentation
  Orland, USA
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] Characterization of two F4/80-positive Kupffer cell subsets by their function and phenotype in mice.2010
- Author(s)
  Kinoshita, M.
- Organizer
  14th International Congress of Immunology.
- Place of Presentation
  Kobe, Japan
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] CpG-oligodeoxynucleotides challenge induces severe multi-organ damage and lethality via TNF and FasL-mediated NKT cell activation in aged mice.2010
- Author(s)
  Kinoshita, M.
- Organizer
  Chemical and Biological Defense Science and Technology (CBD S & T)
- Place of Presentation
  Orland, USA
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] マウスにおけるクッパー細胞の機能的亜分類(ワークショップ)2010
- Author(s)
  木下学
- Organizer
  第20回日本サイトメトリー学会学術集会
- Place of Presentation
  東京
- Year and Date
  2010-06-26
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] Activation of NK cells by IL-18 augments bacterial elimination by Kupffer cells in the burn-injured mice2010
- Author(s)
  Miyazaki H, Kinoshita M, Ono S, Nakashima M, Hara E, Ohno H, Seki S, Daizoh D
- Organizer
  Society for Free Radical Biology and Medicine 17th Annual Meeting
- Place of Presentation
  Orlando, USA
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] 合成CRPの致死的重症感染症に対する予後改善効果-クッパー細胞の貧食能亢進効果と炎症性サイトカイン抑制効果-ショック学会会長賞2010
- Author(s)
  木下学
- Organizer
  第25回日本Shock学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-29
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] Interleukin-18 therapy enhances Kupffer cell-mediated bacterial elimination in post-burn infection models via the activation of NK cell function.2010
- Author(s)
  Kinoshita, M.
- Organizer
  Chemical and Biological Defense Science and Technology (CBD S & T)
- Place of Presentation
  Orland, USA
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] Liposome-encapuslated Hb(LEH)の動物実験モデルでの投与成績-血液交換モデル、経骨輸血モデルでの知見-2010
- Author(s)
  木下学
- Organizer
  第17回日本血液代替物学会
- Place of Presentation
  熊本(招待講演)
- Year and Date
  2010-10-18
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] 貪食活性酸素産生Kupffer細胞とサイトカイン産生Kupffer細胞は異なる-resident Kupffer細胞とimmigrant Kupffer細胞-(シンポジウム)2010
- Author(s)
  木下学
- Organizer
  第16回日本エンドトキシン自然免疫研究会
- Place of Presentation
  奈良
- Year and Date
  2010-11-13
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] Characterization of two F4/80-positive Kupffer cell subsets by their function and phenotype in mice2010
- Author(s)
  Kinoshita M, Uchida T, Sato A, Nakashima M, Nakashima H, Shono S, Habu Y, Miyazaki H, Seki S
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  Kobe Japan
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] CRPの感染防御における役割-マクロファージ系細胞への貪食亢進効果と炎症性サイトカイン産生抑制効果について-2010
- Author(s)
  木下学
- Organizer
  第26回関東小児外科症例検討会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2010-09-20
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] CpG-oligodeoxynucleotides challenge induces severe multi-organ damage and lethality via TNF and FasL-mediated NKT cell activation in aged mice2010
- Author(s)
  Kinoshita M, Shinomiya N, Kawabata T, Seki S
- Organizer
  Chemical and Biological Defense Science and Technology (CBD S&T) 2010
- Place of Presentation
  Orland, USA
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] マウスおよびヒト肝Kupffer細胞/マクロファージの表面抗原、発生分化、機能による包括的分類の新規確立
- Author(s)
  Masami Ikarashi, Hiroyuki Nakashima, Manabu Kinoshita, Shuhji Seki
- Organizer
  日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2014-05-29 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-25460508
[Presentation] Activated CD11b+ Kupffer cells/macrophages play the pivotal role in diet induced steatohepatitis in fibroblast growth factor 5 deficient mice
- Author(s)
  Hiroyuki Nakashima, Manabu Kinoshita, Shuhji Seki
- Organizer
  日本免疫学会総会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25460508
[Presentation] In vivo endotoxin tolerance alters Kupffer cell phenotype and drastically enhances their bacterial killing
- Author(s)
  Manabu Kinoshita, Hiroyuki Nakashima, Shuhji Seki
- Organizer
  日本免疫学会総会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25460508
[Presentation] FIBRINOGEN GAMMA-CHAIN PEPTIDE-COATED, ADP-ENCAPSULATED LIPOSOMES RESCUE MICE
- Author(s)
  K. Hagisawa, M. Kinoshita, H. Miyawaki, H. Miyazaki
- Organizer
  38TH ANNUAL CONFERENCE ON SHOCK
- Place of Presentation
  DENVER, COLORADO
- Year and Date
  2015-06-06 – 2015-06-09
- Data Source
  KAKENHI-PROJECT-25462843
[Presentation] Involvement of the TNF and FasL produced by CD11b Kupffer cells/macrophages in CCl4-induced acute hepatic injury
- Author(s)
  Hiroyuki Nakashima, Atsushi Sato, Manabu Kinoshita, Shuhji Seki
- Organizer
  アメリカ肝臓学会
- Place of Presentation
  アメリカ　ボストン
- Year and Date
  2014-11-07 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-25460508
[Presentation] 同種皮膚を用いた新規熱傷治療法　―マイクロスキンとナノシートの併用療法－
- Author(s)
  宮崎裕美、安西一正、小野聡、木下学、齋藤晃広、武岡真司、齋藤大蔵
- Organizer
  第39回日本熱傷学会総会・学術集会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-25462844
[Presentation] Application of a biodegradable nanosheet as a new dressing for burn wounds
- Author(s)
  Miyazaki H, Kinoshita M, Ono S, Fujie T, Takeoka S, Saitoh　D.
- Organizer
  17th Congress of International Society for Burns Injuries
- Place of Presentation
  Sydney (Australia)
- Year and Date
  2014-10-14 – 2014-10-16
- Data Source
  KAKENHI-PROJECT-25462844
[Presentation] パネルディスカッション熱傷基礎研究の最前線超薄膜ナノシートを応用した熱傷治療
- Author(s)
  宮崎裕美、木下学、小野聡、武岡真司、齋藤大蔵
- Organizer
  第40回日本熱傷学会総会・学術集会
- Place of Presentation
  ラフレ埼玉（埼玉）
- Year and Date
  2014-06-05 – 2014-06-06
- Invited
- Data Source
  KAKENHI-PROJECT-25462844
[Presentation] Burn-evoked reactive oxygen species immediately after injury are important to restore the neutrophil function against post-burn infection in mice
- Author(s)
  宮崎裕美、木下学、小野聡、関修司、齋藤大蔵
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  国立京都国際会館（京都市）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26462773
[Presentation] Fibrinogen gamma-chain peptide-coated, Adenosine Diphosphate-encapsulated Liposomes Rescue Lethal Blast Lung Injury Hemorrhage via Purinergic Signaling.
- Author(s)
  Hagisawa K, Kinoshita M, Miyawaki H
- Organizer
  American Heart Association 2014 Resuscitation Science Symposium, (Young Investigator Award受賞)
- Place of Presentation
  Chicago
- Year and Date
  2014-11-15 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-25462843

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kinoshita manabu 木下 学

KINOSHITA Manabu 木下 学

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ミトコンドリア機能と品質管理機構から捉える重症病態の分子病態研究Ongoing

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新規LXR刺激物質を用いた肝臓免疫細胞の機能解析Ongoing

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リポ多糖の前投与がミクログリアを介した抑うつ症状の発症を抑制するメカニズムの研究Ongoing

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川崎病血管炎における好中球サブセット動態の解析と重症度予測への応用Ongoing

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LPSプレコンディショニングによるマラリア重篤化抑制手法の確立Ongoing

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Treatment of trauma induced coagulopathy with H12-ADP-liposomeOngoing

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妊娠家兎を用いた危機的産科出血に対する人工酸素運搬体投与による救命効果の研究Ongoing

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Preventive effect of postoperative liver failure and promotion of liver regeneration after massive hepatectomy by LPS toleranceOngoing

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細胞担持ナノシートと蛍光遺伝子導入を用いた新しい脂肪由来幹細胞移植法の研究Ongoing

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Novel therapeutic strategy against drug-resistant bacterial sepsis in compromised hosts focusing on enhancing bactericidal activity of macrophagesPrincipal InvestigatorOngoing

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Compromised hostでの免疫不全の病態解析と高度侵襲対策Ongoing

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kinoshita manabu 木下学

KINOSHITA Manabu 木下学