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HAGISAWA KOHSUKE  萩沢 康介

Researcher Number 50539244
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-1600-4570
Affiliation (Current) 2020: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 生理学, 助教
Affiliation (based on the past Project Information) *help 2016 – 2019: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 生理学, 助教
2016: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 生理学, 助教
2015: 防衛医科大学校, その他部局等, 助教
2014 – 2015: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, その他部局等, 助教
2013 – 2015: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 助教
Review Section/Research Field
Principal Investigator
Emergency medicine / Basic Section 49030:Experimental pathology-related
Except Principal Investigator
Emergency medicine / Biomedical engineering/Biomaterial science and engineering / Basic Section 56040:Obstetrics and gynecology-related
Keywords
Principal Investigator
血小板代替物 / 凝固障害 / Blast Lung Injury / 止血凝固作用 / アデノシン作用 / レーザー誘起衝撃波 / ドラッグデリバリシステム / アデノシン / 止血作用 / 抗サイトカイン作用 … More / 救急医療 / 出血性ショック / 血液代替物 / 病院前治療 / 蘇生輸血 / 外傷 / DIC … More
Except Principal Investigator
compromised hosts / 外科侵襲 / クッパー細胞 / レスベラトロール / ursodepxycolic acid / ナノシート / 止血ナノ粒子 / 光線力学療法 / エンドトキシントレランス / 活性酸素 / 重症感染症 / ナノ医学 / 核内受容体 / グルココルチコイド受容体 / 合成CRP / 生体分子 / 生理活性 / 人工酸素運搬体 / 産科危機的出血 / 血液代替物 Less
  • Research Projects

    (6 results)
  • Research Products

    (44 results)
  • Co-Researchers

    (24 People)
  •  Treatment of trauma induced coagulopathy with H12-ADP-liposomePrincipal InvestigatorOngoing

    • Principal Investigator
      萩沢 康介
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      National Defense Medical College
  •  妊娠家兎を用いた危機的産科出血に対する人工酸素運搬体投与による救命効果の研究Ongoing

    • Principal Investigator
      結城 由香子
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Saitama Medical University
  •  Combination therapy using fibrinogen gamma-chain peptide-coated, ADP-encapsulated liposomes and hemoglobin vesicles for trauma-induced massive hemorrhagePrincipal Investigator

    • Principal Investigator
      Hagisawa Kohsuke
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Emergency medicine
    • Research Institution
      National Defense Medical College
  •  Can a natural amino acid be used for diagnosis and treatment for arteriosclerosis

    • Principal Investigator
      Morimoto Yuji
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Biomedical engineering/Biomaterial science and engineering
    • Research Institution
      National Defense Medical College
  •  Management against surgical stress in compromised hosts

    • Principal Investigator
      Kinoshita Manabu
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Emergency medicine
    • Research Institution
      National Defense Medical College
  •  The Novel Hemostatic and Tissue Protective Treatment Elucidating the Pathophysiology of Blast Lung InjuryPrincipal Investigator

    • Principal Investigator
      HAGISAWA KOHSUKE
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Emergency medicine
    • Research Institution
      National Defense Medical College

All 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

  • [Journal Article] Combination therapy using fibrinogen gamma-chain peptide-coated, ADP-encapsulated liposomes and hemoglobin vesicles for trauma-induced massive hemorrhage in thrombocytopenic rabbits2019

    • Author(s)
      Hagisawa K, Kinoshita M, Takikawa M, Takeoka S, Saitoh D, Seki S, Sakai H
    • Journal Title

      Transfusion

      Volume: 59

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K11435
  • [Journal Article] Efficacy of Resuscitative Transfusion With Hemoglobin Vesicles in the Treatment of Massive Hemorrhage in Rabbits With Thrombocytopenic Coagulopathy and Its Effect on Hemostasis by Platelet Transfusion2018

    • Author(s)
      Hagisawa, Kohsuke; Kinoshita, Manabu; Takase, Bonpei; Hashimoto, Kenichi; Saitoh, Daizoh; Seki, Shuhji; Nishida, Yasuhiro; Sakai, Hiromi
    • Journal Title

      SHOCK

      Volume: in press Pages: 324-330

    • DOI

      10.1097/shk.0000000000001042

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K11435, KAKENHI-PROJECT-18H02907
  • [Journal Article] 出血性ショックと凝固障害を人工血液で制御する2018

    • Author(s)
      萩沢康介、木下学
    • Journal Title

      Shock(第32回日本Shock学会総会プロシーディング)

      Volume: 32 Pages: 14-17

    • Data Source
      KAKENHI-PROJECT-16K11435
  • [Journal Article] Fibrinogen γ-Chain Peptide-Coated Adenosine 5' Diphosphate-Encapsulated Liposomes Rescue Mice From Lethal Blast Lung Injury via Adenosine Signaling.2016

    • Author(s)
      Hagisawa K, Miyawaki H, Kinoshita M, Miyazaki H, Yanagawa R, Doi M, Takeoka S, Suzuki H, Seki S, Saitoh D, Nishida Y, Handa M.
    • Journal Title

      Critical Care Medicine

      Volume: 44

    • DOI

      10.1097/ccm.0000000000001707

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25462843
  • [Journal Article] Treatment with fibrinogen -chain peptide-coated, ADP-encapsulated liposomes as an infusible haemostatic agent against active liver bleeding in acute thrombocytopenic rabbits.2015

    • Author(s)
      Hagisawa K, Nishikawa K, Yanagawa R, Kinoshita M, Doi M, Suzuki H, Iwaya K, Saitoh D, Seki S, Takeoka S, Handa M, Nishida Y.
    • Journal Title

      Transfusion

      Volume: 55 Pages: 314-25

    • DOI

      10.1111/trf.12829

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25462843, KAKENHI-PROJECT-25504021, KAKENHI-PROJECT-25293369
  • [Journal Article] Catecholamine vasomotive effect rescue mice with blast lung injury caused by laser-induced shock wave in super acute phase.2015

    • Author(s)
      Miyawaki H, Saito D, Hagisawa K, Noguchi M, Sato S, Kinoshita M, Miyazaki H, Sato Y, Harada N, Sakamoto T.
    • Journal Title

      Int Care Med Exp

      Volume: 32 Pages: 32-32

    • DOI

      10.1186/s40635-015-0069-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25462843, KAKENHI-PROJECT-25293369
  • [Journal Article] 衝撃波による致死的肺出血マウスに対する人工血小板(H12-ADP-liposome)の救命効果2014

    • Author(s)
      萩沢康介、木下学、宮脇博基、佐藤俊一、鈴木英紀、土井麻美、武岡真司、小野聡、斎藤大蔵、西田育弘
    • Journal Title

      Shock (日本ショック学会雑誌)

      Volume: 29 Pages: 1-8

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25462843
  • [Journal Article] Effective control of massive venous bleeding by “multi-overlapping therapy” using polysaccharide nanosheets in rabbit inferior vena cava injury model.2013

    • Author(s)
      Hagisawa K, Saito A, Kinoshita M, Fujie T, Otani N, Shono S, Park YK, Takeoka S
    • Journal Title

      J. Vasc. Surg: Venous and Lymphatic Disorders.

      Volume: 1 Pages: 289-297

    • DOI

      10.1016/j.jvsv.2013.04.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293369
  • [Journal Article] 人工血小板H12(ADP)リポソームを用いた急性血小板減少病態への止血・救命対策.2013

    • Author(s)
      西川可穂子、萩沢康介、柳川錬平、土井麻実、鈴木英紀、齋藤大蔵、阪本敏久、武岡真司、半田誠、木下 学
    • Journal Title

      人工血液

      Volume: 21 Pages: 60-67

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293369
  • [Journal Article] ナノ粒子による外傷性大量出血の止血治療2013

    • Author(s)
      萩沢康介、木下 学、西川可穂子、柳川錬平、土井麻実、西田育夫、齋藤大蔵
    • Journal Title

      Bio Industry

      Volume: 30 Pages: 3-9

    • Data Source
      KAKENHI-PROJECT-25293369
  • [Journal Article] Novel therapeutic usage of polysaccharide nanosheets for aracinoid plasty and reinforcement of venous tensile strength in rat microneurosurgery.2013

    • Author(s)
      Otani, N
    • Journal Title

      J. Clin. Neurosci.

      Volume: 20 Pages: 301-305

    • DOI

      10.1016/j.jocn.2012.05.028

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22592027, KAKENHI-PROJECT-25293369
  • [Presentation] 5-アミノレブリン酸によるアテローム性動脈硬化プラークの進行抑制2018

    • Author(s)
      丹羽貴郁、萩沢康介、守本祐司、他
    • Organizer
      第95回日本生理学会大会
    • Data Source
      KAKENHI-PROJECT-16K12885
  • [Presentation] Intraosseous Transfusion With Hemoglobin Vesicles for Severe Hemorrhagic Shock Rabbits2018

    • Author(s)
      Hagisawa Kohsuke, Kinoshita Manabu, Sakai Hiromi
    • Organizer
      American Heart Association 2018 Resuscitation Science Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K11435
  • [Presentation] 動脈硬化プラークにおける5-アミノレブリン酸投与後に観察される蛍光2018

    • Author(s)
      広富優華、萩沢康介、守本祐司、他
    • Organizer
      第63回防衛衛生学会
    • Data Source
      KAKENHI-PROJECT-16K12885
  • [Presentation] Combination Therapy with Red Blood Cell Substitute and Platelet Substitute Effectively Rescues Rabbits from Massive Hemorrhage Caused by Thrombocytopenic Coagulopathy.2017

    • Author(s)
      Kinoshita Manabu, Hagisawa Kohsuke, Sakai Hiromi, Takeoka Shinji, Saitoh Daizoh, Shinomiya Nariyoshi, Seki Shuhji
    • Organizer
      Military Health System Research Symposium 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K11435
  • [Presentation] 動脈硬化プラークのイメージングにおける5-アミノレブリン酸の有用性2017

    • Author(s)
      鬼木玲奈、萩沢康介、守本祐司、他
    • Organizer
      第38回日本レーザー医学会総会
    • Data Source
      KAKENHI-PROJECT-16K12885
  • [Presentation] 動脈硬化プラークにおける5-アミノレブリン酸投与後に観察される蛍光2017

    • Author(s)
      長井 健一郎、萩沢康介、守本祐司、他
    • Organizer
      第27回日本光線力学学会学術大会
    • Data Source
      KAKENHI-PROJECT-16K12885
  • [Presentation] Aminolevulinic acid attenuates atherosclerotic plaque progression of LDL receptor deficient mice by an antioxidant action2017

    • Author(s)
      Hagisawa Kohsuke, Morimoto Yuji
    • Organizer
      American Heart Association Scientific Sessions 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K12885
  • [Presentation] Complete Blood Substitute for Massive Transfusion in Thrombocytopenic and Hemorrhagic Shock Rabbits.2017

    • Author(s)
      Hagisawa Kohsuke, Kinoshita Manabu
    • Organizer
      American Heart Association 2017 Resuscitation Science Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K11435
  • [Presentation] 動脈硬化プラーク検知に5-ALAが使える可能性2017

    • Author(s)
      丹羽貴郁、萩沢康介、守本祐司、他
    • Organizer
      第35回日本ヒト細胞学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K12885
  • [Presentation] Hemoglobin Vesicles and Fibrinogen gamma-chain peptide-coated, Adenosine Diphosphate-encapsulated Liposomes Rescue Rabbits from Hemorrhagic Shock with Trauma-Induced Coagulopathy.2017

    • Author(s)
      Hagisawa Kohsuke, Kinoshita Manabu
    • Organizer
      2017 Shock Society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K11435
  • [Presentation] マルチスペクトル蛍光内視鏡と5-アミノレブリン酸を用いた動脈硬化プラークの診断2017

    • Author(s)
      萩沢康介、守本祐司、他
    • Organizer
      第7回ポルフィリン-ALA学会
    • Data Source
      KAKENHI-PROJECT-16K12885
  • [Presentation] Resuscitation by transfusion with Hemoglobin Vesicles in Trauma Hemorrhagic Shock / Coagulopathy Rabbits.2016

    • Author(s)
      Hagisawa K, Kinoshita M
    • Organizer
      American Heart Association 2016 Resuscitation Science Symposium
    • Place of Presentation
      New Orleans, LA
    • Year and Date
      2016-11-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K11435
  • [Presentation] Prehospital transfusion with H12-ADP-liposome instead of conventional Platelet concentrate.2016

    • Author(s)
      Hagisawa K, Takikawa M, Kinoshita M
    • Organizer
      39th Annual Conference on Shock
    • Place of Presentation
      Austin, TX
    • Year and Date
      2016-06-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K11435
  • [Presentation] 大量出血性凝固障害をH12-ADP-liposomeで制御する -最適の病院前治療に向けて-2016

    • Author(s)
      萩沢康介、木下学、多喜川真人、武岡真司、鈴木英紀、宮崎裕美、斎藤大蔵
    • Organizer
      第23回日本血液代替物学会年次大会
    • Place of Presentation
      東京
    • Year and Date
      2016-11-24
    • Data Source
      KAKENHI-PROJECT-16K11435
  • [Presentation] Resuscitation by transfusion with hemoglobin vesicle in trauma hemorrhagic shock/ coagulopathy rabbits.2015

    • Author(s)
      Hagisawa k, Kinoshita, M Sakai H, Nishida Y.
    • Organizer
      American Heart Association 2015 Resuscitation science symposium
    • Place of Presentation
      Orlando FL
    • Year and Date
      2015-11-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293369
  • [Presentation] レーザー衝撃波による肺出血に対するH12-ADP-liposomeの救命効果2015

    • Author(s)
      萩沢康介、木下学、宮脇博基、佐藤俊一、鈴木英紀ら
    • Organizer
      第22回日本血液代替物学会 シンポジウム・人工血小板の新しい展開に向けて
    • Place of Presentation
      熊本
    • Year and Date
      2015-10-23
    • Data Source
      KAKENHI-PROJECT-25462843
  • [Presentation] Fibrinogen gamma-chain peptide-coated, ADP-encapsulated liposomes rescue mice from lethal blast lung injury2015

    • Author(s)
      Hagisawa K, Kinoshita M, Miyawaki H, Miyazaki H, Nishida Y.
    • Organizer
      38th Annual congress on Shock
    • Place of Presentation
      Denver CO
    • Year and Date
      2015-06-06
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293369
  • [Presentation] 救急医療における人工血小板の必要性と展望2015

    • Author(s)
      木下学、萩沢康介、朝比奈はるか、田中良弘、齊藤大蔵、高瀬凡平
    • Organizer
      第22回日本血液代替物学会
    • Place of Presentation
      熊本
    • Year and Date
      2015-10-22
    • Data Source
      KAKENHI-PROJECT-25293369
  • [Presentation] Peroxisome proliferator activated receptor-gamma agonist improves survival in a murine model of postburn infection by modulating the macrophage function2015

    • Author(s)
      Miyazaki H, Kinoshita M, Hagisawa K, Seki S, Saitoh D.
    • Organizer
      38th Annual congress on Shock
    • Place of Presentation
      Denver CO
    • Year and Date
      2015-06-06
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293369
  • [Presentation] 家兎での血小板減少時の肝損傷に対する人工血小板による止血救命2015

    • Author(s)
      木下学、萩沢康介、西川可穂子、柳川錬平、関修司
    • Organizer
      第51回日本腹部救急医学会
    • Place of Presentation
      京都
    • Year and Date
      2015-03-06
    • Data Source
      KAKENHI-PROJECT-25293369
  • [Presentation] 凝固障害を伴う出血性ショックに対して人工赤血球による蘇生の試み2015

    • Author(s)
      朝比奈はるか、萩沢康介、木下学、齊藤大蔵
    • Organizer
      第22回日本血液代替物学会
    • Place of Presentation
      熊本
    • Year and Date
      2015-10-22
    • Data Source
      KAKENHI-PROJECT-25293369
  • [Presentation] Burn-evoked ROS immediately after injury are crucial to rescue the neutrophil function against post-burn infection in mice2015

    • Author(s)
      Kinoshita M, Miyazaki H, Ono S, Hagisawa K, Saitoh D, Seki S,
    • Organizer
      38th Annual congress on Shock
    • Place of Presentation
      Denver CO
    • Year and Date
      2015-06-06
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293369
  • [Presentation] 衝撃波による致死的肺出血マウスに対する人工血小板(H12-ADP-liposome)の救命効果2014

    • Author(s)
      萩沢康介、木下学、宮脇博基ら
    • Organizer
      第29回日本Shock学会
    • Place of Presentation
      松山市
    • Data Source
      KAKENHI-PROJECT-25462843
  • [Presentation] 衝撃波による致死的肺出血マウスに対する人工血小板(H12-ADP-liposome)の救命効果2014

    • Author(s)
      2.萩沢康介、木下学、宮脇博基、佐藤俊一、鈴木英紀、土井麻美、武岡真司、小野聡、斎藤大蔵、西田育弘
    • Organizer
      第29回日本ショック学会 学会長賞受賞
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2014-05-17
    • Data Source
      KAKENHI-PROJECT-25462843
  • [Presentation] 人工赤血球や人工血小板などの血液代替物の開発とその将来展望2014

    • Author(s)
      木下 学、萩沢康介、西川可穂子、柳川錬平、小野 聡、齋藤大蔵、高瀬凡平、酒井宏水、半田誠、武岡真司、関 修司
    • Organizer
      第114回日本外科学会定期学術集会 (パネルデスカッション1-3)
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-25293369
  • [Presentation] 人工赤血球や人工血小板などの血液代替物の開発とその将来展望2014

    • Author(s)
      木下 学, 萩沢康介, 西川可穂子
    • Organizer
      第113回日本外科学会定期学術集会パネルディスカッション
    • Place of Presentation
      京都
    • Year and Date
      2014-04-03
    • Data Source
      KAKENHI-PROJECT-25293369
  • [Presentation] H12-ADP-liposomeの新たな適応: 衝撃波による肺出血マウスに対するH12-ADP-liposomeの救命効果2013

    • Author(s)
      萩沢康介、木下学、宮脇博基ら
    • Organizer
      第20回日本血液代替物学会 シンポジウム人工血小板/H12-(ADP)リポソームの前臨床
    • Place of Presentation
      奈良市
    • Data Source
      KAKENHI-PROJECT-25462843
  • [Presentation] 大量出血後の血小板減少状態下での肝外傷出血に対するH12(ADP)リポソーム投与の止血救命効果.2013

    • Author(s)
      萩沢康介、木下 学、西川可穂子、柳川錬平、土井麻実、武岡真司、齋藤大蔵、関 修司、西田育弘、半田 誠
    • Organizer
      日本血栓止血学会第85回学術集会
    • Place of Presentation
      山形
    • Data Source
      KAKENHI-PROJECT-25293369
  • [Presentation] Treatment with Fibrinogen γ-chain Peptide-coated, Adenosine Diphosphate-encapsulated Liposomes as An Infusible Haemostatic Agent for Dilutional Coagulopathy.2013

    • Author(s)
      Hagisawa K, Kinoshita M, Nishikawa K, Nishida Y
    • Organizer
      American Heart Association 2013. Resuscitation Science Symposium
    • Place of Presentation
      Dallas
    • Data Source
      KAKENHI-PROJECT-25293369
  • [Presentation] H12(ADP)liposomeの新たな適応:衝撃波による肺出血に対するH12(ADP)liposomeの救命効果.2013

    • Author(s)
      萩沢康介、木下 学、宮脇博基、佐藤俊一、鈴木英紀、土井麻実、武岡真司、齋藤大蔵、西田育弘
    • Organizer
      第20回日本血液代替物学会(シンポジウム2-5)
    • Place of Presentation
      奈良
    • Data Source
      KAKENHI-PROJECT-25293369
  • [Presentation] 人工血小板H12(ADP)liposomeの止血能評価(臓器損傷後投与による検討)2013

    • Author(s)
      土井麻実、木下 学、萩沢康介、西川可穂子、柳川錬平、半田 誠、池田康夫、武岡真司
    • Organizer
      第20回日本血液代替物学会(シンポジウム2-5)
    • Place of Presentation
      奈良
    • Data Source
      KAKENHI-PROJECT-25293369
  • [Presentation] FIBRINOGEN GAMMA-CHAIN PEPTIDE-COATED, ADP-ENCAPSULATED LIPOSOMES RESCUE MICE

    • Author(s)
      K. Hagisawa, M. Kinoshita, H. Miyawaki, H. Miyazaki
    • Organizer
      38TH ANNUAL CONFERENCE ON SHOCK
    • Place of Presentation
      DENVER, COLORADO
    • Year and Date
      2015-06-06 – 2015-06-09
    • Data Source
      KAKENHI-PROJECT-25462843
  • [Presentation] Fibrinogen gamma-chain peptide-coated, Adenosine Diphosphate-encapsulated Liposomes Rescue Lethal Blast Lung Injury Hemorrhage via Purinergic Signaling.

    • Author(s)
      Hagisawa K, Kinoshita M, Miyawaki H
    • Organizer
      American Heart Association 2014 Resuscitation Science Symposium, (Young Investigator Award受賞)
    • Place of Presentation
      Chicago
    • Year and Date
      2014-11-15 – 2014-11-16
    • Data Source
      KAKENHI-PROJECT-25462843
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